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RNF219 Gene

protein-coding   GIFtS: 45
GCID: GC13M079188

Ring Finger Protein 219

(Previous name: chromosome 13 open reading frame 7)
(Previous symbol: C13orf7)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ring Finger Protein 2191 2
C13orf71 2 3
Chromosome 13 Open Reading Frame 71

External Ids:    HGNC: 203081   Entrez Gene: 795962   Ensembl: ENSG000001521937   UniProtKB: Q5W0B13   

Export aliases for RNF219 gene to outside databases

Previous GC identifers: GC13M078087 GC13M059888


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RNF219 Gene:
RNF219 (ring finger protein 219) is a protein-coding gene. Diseases associated with RNF219 include prostate disease, and prostatitis.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000013.11  NT_024524.15  NC_018924.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RNF219 gene promoter:
         LHX3b/Lhx3b   HOXA3   AML1a   Pax-2   Ik-3   E47   Pax-2b   LHX3a/Lhx3a   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNF219 promoter sequence
   Search Chromatin IP Primers for RNF219

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNF219


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q31.1   Ensembl cytogenetic band:  13q31.1   HGNC cytogenetic band: 13q31.1

RNF219 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF219 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M079188:  view genomic region     (about GC identifiers)

Start:
79,188,421 bp from pter      End:
79,233,314 bp from pter
Size:
44,894 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RN219_HUMAN, Q5W0B1 (See protein sequence)
Recommended Name: RING finger protein 219  
Size: 726 amino acids; 81116 Da
Sequence caution: Sequence=BAB14594.1; Type=Erroneous initiation; Sequence=BC028586; Type=Frameshift;
Positions=614; Sequence=CAB66586.3; Type=Frameshift; Positions=614;
Secondary accessions: B2RN99 Q8TBY2 Q9H0T2 Q9H8M0

Explore the universe of human proteins at neXtProt for RNF219: NX_Q5W0B1

Explore proteomics data for RNF219 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys292, Lys569
  • Modification sites at PhosphoSitePlus

  • See RNF219 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_078822.3  
    ENSEMBL proteins: 
     ENSP00000282003  

    RNF219 Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for RNF219


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers

    2 InterPro protein domains:
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q5W0B1

    ProtoNet protein and cluster: Q5W0B1

    UniProtKB/Swiss-Prot: RN219_HUMAN, Q5W0B1
    Similarity: Contains 1 RING-type zinc finger


    RNF219 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
         
    RNF219 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RNF219
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RNF219

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RNF219
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RNF219

    miRNA
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    miRTarBase miRNAs that target RNF219:
    hsa-mir-192-5p (MIRT026428), hsa-mir-148b-3p (MIRT019400), hsa-mir-218-5p (MIRT024235), hsa-mir-215-5p (MIRT024258)

    Block miRNA regulation of human, mouse, rat RNF219 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RNF219 (see all 19):
    hsa-miR-520f hsa-miR-148b hsa-miR-4272 hsa-miR-16-1* hsa-miR-218 hsa-miR-23a hsa-miR-3662 hsa-miR-376c
    SwitchGear 3'UTR luciferase reporter plasmidRNF219 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RNF219
    Predesigned siRNA for gene silencing in human, mouse, rat RNF219

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for RNF219 (see all 7)
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    GenScript: all cDNA clones in your preferred vector: RNF219 (NM_024546)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF219

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF219


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion2
    nucleus2
    cytoskeleton1
    cytosol1
    extracellular1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including RNF219: 
              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for RNF219

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for RNF219 (Q5W0B13 ENSP000002820034) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CTNNA1P352213, ENSP000003046694I2D: score=3 STRING: ENSP00000304669
    BCKDKO148743, ENSP000002197944I2D: score=1 STRING: ENSP00000219794
    BRF2Q9HAW03, ENSP000002206594I2D: score=1 STRING: ENSP00000220659
    TTC4O958013, ENSP000003603294I2D: score=1 STRING: ENSP00000360329
    WRAP73Q9P2S53, ENSP000002707084I2D: score=1 STRING: ENSP00000270708
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RNF219 (RN219)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RNF219 gene: 
    NM_024546.3  

    Unigene Cluster for RNF219:

    Ring finger protein 219
    Hs.567576  [show with all ESTs]
    Unigene Representative Sequence: CR936752
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000282003(uc001vkw.1 uc010afb.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RNF219 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RNF219 (see all 19):
    hsa-miR-520f hsa-miR-148b hsa-miR-4272 hsa-miR-16-1* hsa-miR-218 hsa-miR-23a hsa-miR-3662 hsa-miR-376c
    SwitchGear 3'UTR luciferase reporter plasmidRNF219 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RNF219
    Predesigned siRNA for gene silencing in human, mouse, rat RNF219
    Clone
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    OriGene clones in human, mouse for RNF219 (see all 7)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RNF219 (NM_024546)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNF219
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF219
    Primer
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    OriGene qPCR primer pairs and template standards for RNF219
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RNF219
      QuantiTect SYBR Green Assays in human, mouse, rat RNF219
      QuantiFast Probe-based Assays in human, mouse, rat RNF219

    Additional mRNA sequence: 

    AK023511.1 AK098640.1 AL136651.1 BC028586.1 BC136764.1 BC136765.1 CR936752.1 CR936754.1 
    CR936764.1 

    11 DOTS entries:

    DT.101963493  DT.412951  DT.100767940  DT.95279587  DT.70104829  DT.120795948  DT.40109569  DT.120795931 
    DT.120795845  DT.120795885  DT.91998068 

    Selected AceView cDNA sequences (see all 95):

    BM701567 CD108555 CB118834 AA808219 AK098640 AI377424 BM674566 AA237068 
    BQ437398 BG741490 CB146339 CR591202 AA236869 BQ787049 AJ243230 BX488506 
    AI951517 NM_024546 AL136651 AI167544 BG292548 AK023511 AA724774 BM923609 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RNF219 (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d
    SP1:        -     -     -     -     -     -           -                                   -                                 
    SP2:                                -     -           -                                   -     -                           
    SP3:                                -     -           -                                                                     
    SP4:                                                                                      -     -                           
    SP5:                    -     -     -     -           -                                                                     


    ECgene alternative splicing isoforms for RNF219

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RNF219 expression in normal human tissues (normalized intensities)      RNF219 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTTTCTATG
    RNF219 Expression
    About this image


    RNF219 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Limb (Muscoskeletal System)
             Limb Bud
    RNF219 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RNF219 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.567576
        Pathway & Disease-focused RT2 Profiler PCR Array including RNF219: 
              Ubiquitin Ligases in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat RNF219
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF219

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for RNF219 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnf2191 , 5 ring finger protein 2191, 5 83.1(n)1
    81.16(a)1
      14 (54.24 cM)5
    724861  NM_026047.41  NP_080323.31 
     1044775345 
    chicken
    (Gallus gallus)
    Aves RNF2191 ring finger protein 219 68.41(n)
    60.68(a)
      418805  XM_416999.4  XP_416999.4 
    lizard
    (Anolis carolinensis)
    Reptilia RNF2196
    ring finger protein 219
    54(a)
    1 ↔ 1
    3(97483026-97513629)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia AL784101.22   -- 78.25(n)    AL784101.2 
    zebrafish
    (Danio rerio)
    Actinopterygii RNF2196
    ring finger protein 219
    44(a)
    1 ↔ 1
    6(4421265-4428564) ENSDARG00000090904


    ENSEMBL Gene Tree for RNF219 (if available)
    TreeFam Gene Tree for RNF219 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RNF219 (see all 862)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs27650681,2
    C,F,A--79191980(+) AAAAAT/ATTTTT 1 -- int1 trp36Minor allele frequency- A:0.47NA WA EA 364
    rs2020995511,2
    --79191980(+) AAAAA-/TTTTTT 1 -- int10--------
    rs1485356941,2
    C--79192092(+) ATTTCC/TACCAA 1 -- int10--------
    rs170700471,2
    C,F--79192107(+) GAGTAC/TTGTGT 1 -- int14Minor allele frequency- T:0.02NA WA 260
    rs9812281,2
    C,F,O,A,H--79192171(-) GTTCCC/TAGCCC 1 -- int19Minor allele frequency- T:0.38NA WA EA 504
    rs1167980721,2
    F--79192210(+) CAAGGG/AACATA 1 -- int11Minor allele frequency- A:0.05WA 118
    rs1425959231,2
    --79192241(+) ATCTTA/GTCACC 1 -- int10--------
    rs1179014011,2
    C,F--79192298(+) ATAATC/ACCGTG 1 -- int11Minor allele frequency- A:0.02NA 120
    rs1884590001,2
    --79192301(+) ATCCCA/GTGAAA 1 -- int10--------
    rs9812271,2
    C,F,O,A,H--79192316(-) AGGAGA/TTAAGG 1 -- int113Minor allele frequency- T:0.37NS EA NA WA 918

    HapMap Linkage Disequilibrium report for RNF219 (79188421 - 79233314 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for RNF219 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2747700CNV Deletion23290073
    esv2421781CNV Deletion20811451
    esv2667717CNV Deletion23128226
    nsv1098CNV Insertion18451855
    dgv234n27CNV Loss19166990
    nsv517259CNV Loss19592680
    nsv900582CNV Loss21882294
    nsv514712CNV Loss21397061
    dgv340n67CNV Loss20364138
    dgv339n67CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RNF219
    DNA2.0 Custom Variant and Variant Library Synthesis for RNF219

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases for RNF219:    About MalaCards
    prostate disease    prostatitis


    RNF219 for disorders           About GeneDecksing


    Export disorders for RNF219 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RNF219 gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with RNF219)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (Nature 2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    5. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    6. The functional interactome landscape of the human histone deacetylase family. (PubMed id 23752268)1 Joshi P....Cristea I.M. (Mol. Syst. Biol. 2013)
    7. Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (J. Proteome Res. 2012)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79596 HGNC: 20308 AceView: C13orf7 Ensembl:ENSG00000152193 euGenes: HUgn79596
    ECgene: RNF219 H-InvDB: RNF219

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RNF219 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RNF219 gene:
    Search GeneIP for patents involving RNF219

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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