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Aliases for RNF219 Gene

Aliases for RNF219 Gene

  • Ring Finger Protein 219 2 3
  • C13orf7 3 4
  • Chromosome 13 Open Reading Frame 7 2

External Ids for RNF219 Gene

Previous HGNC Symbols for RNF219 Gene

  • C13orf7

Previous GeneCards Identifiers for RNF219 Gene

  • GC13M078087
  • GC13M079188
  • GC13M059888

Summaries for RNF219 Gene

GeneCards Summary for RNF219 Gene

RNF219 (Ring Finger Protein 219) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF219 Gene

Genomics for RNF219 Gene

Regulatory Elements for RNF219 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RNF219 Gene

Chromosome:
13
Start:
78,614,286 bp from pter
End:
78,659,179 bp from pter
Size:
44,894 bases
Orientation:
Minus strand

Genomic View for RNF219 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNF219 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF219 Gene

Proteins for RNF219 Gene

  • Protein details for RNF219 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5W0B1-RN219_HUMAN
    Recommended name:
    RING finger protein 219
    Protein Accession:
    Q5W0B1
    Secondary Accessions:
    • B2RN99
    • Q8TBY2
    • Q9H0T2
    • Q9H8M0

    Protein attributes for RNF219 Gene

    Size:
    726 amino acids
    Molecular mass:
    81116 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14594.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BC028586; Type=Frameshift; Positions=614; Evidence={ECO:0000305}; Sequence=CAB66586.3; Type=Frameshift; Positions=614; Evidence={ECO:0000305};

neXtProt entry for RNF219 Gene

Proteomics data for RNF219 Gene at MOPED

Post-translational modifications for RNF219 Gene

  • Ubiquitination at Lys 292 and Lys 569
  • Modification sites at PhosphoSitePlus

Other Protein References for RNF219 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RNF219 Gene

Domains & Families for RNF219 Gene

Gene Families for RNF219 Gene

Protein Domains for RNF219 Gene

Suggested Antigen Peptide Sequences for RNF219 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5W0B1

UniProtKB/Swiss-Prot:

RN219_HUMAN :
  • Contains 1 RING-type zinc finger.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF219: view

Function for RNF219 Gene

Gene Ontology (GO) - Molecular Function for RNF219 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with RNF219: view
genes like me logo Genes that share phenotypes with RNF219: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RNF219 Gene

Localization for RNF219 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNF219 Gene COMPARTMENTS Subcellular localization image for RNF219 gene
Compartment Confidence
cytoskeleton 2
cytosol 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RNF219 Gene

Pathways & Interactions for RNF219 Gene

SuperPathways for RNF219 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for RNF219 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048026 positive regulation of mRNA splicing, via spliceosome IEA --
genes like me logo Genes that share ontologies with RNF219: view

No data available for Pathways by source and SIGNOR curated interactions for RNF219 Gene

Drugs & Compounds for RNF219 Gene

No Compound Related Data Available

Transcripts for RNF219 Gene

Unigene Clusters for RNF219 Gene

Ring finger protein 219:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNF219

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF219 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d
SP1: - - - - - - - -
SP2: - - - - -
SP3: - - -
SP4: - -
SP5: - - - - -
SP6: - - - - - -
SP7: -
SP8: - -

Relevant External Links for RNF219 Gene

GeneLoc Exon Structure for
RNF219
ECgene alternative splicing isoforms for
RNF219

Expression for RNF219 Gene

mRNA expression in normal human tissues for RNF219 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RNF219 Gene

This gene is overexpressed in Liver, secretome (51.7) and Testis (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RNF219 Gene



SOURCE GeneReport for Unigene cluster for RNF219 Gene Hs.567576

genes like me logo Genes that share expression patterns with RNF219: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for RNF219 Gene

Orthologs for RNF219 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNF219 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RNF219 35
  • 90.19 (n)
  • 90.24 (a)
RNF219 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNF219 35
  • 92.24 (n)
  • 92.89 (a)
RNF219 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnf219 35
  • 83.1 (n)
  • 81.16 (a)
Rnf219 16
Rnf219 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RNF219 35
  • 99.68 (n)
  • 99.59 (a)
RNF219 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnf219 35
  • 81.24 (n)
  • 79.94 (a)
oppossum
(Monodelphis domestica)
Mammalia RNF219 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RNF219 36
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves RNF219 35
  • 68.41 (n)
  • 60.68 (a)
RNF219 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RNF219 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf219 35
  • 57.32 (n)
  • 50.3 (a)
zebrafish
(Danio rerio)
Actinopterygii RNF219 36
  • 44 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4956 36
  • 36 (a)
OneToOne
Species with no ortholog for RNF219:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF219 Gene

ENSEMBL:
Gene Tree for RNF219 (if available)
TreeFam:
Gene Tree for RNF219 (if available)

Paralogs for RNF219 Gene

No data available for Paralogs for RNF219 Gene

Variants for RNF219 Gene

Structural Variations from Database of Genomic Variants (DGV) for RNF219 Gene

Variant ID Type Subtype PubMed ID
dgv339n67 CNV Gain 20364138
dgv234n27 CNV Loss 19166990
nsv900582 CNV Loss 21882294
nsv1098 CNV Insertion 18451855
dgv340n67 CNV Loss 20364138
esv2667717 CNV Deletion 23128226
esv2747700 CNV Deletion 23290073
esv2421781 CNV Deletion 20811451
nsv442321 CNV CNV 18776908
nsv514712 CNV Loss 21397061
nsv517259 CNV Loss 19592680

Variation tolerance for RNF219 Gene

Residual Variation Intolerance Score: 22.43% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.91; 35.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNF219 Gene

HapMap Linkage Disequilibrium report
RNF219

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for RNF219 Gene

Disorders for RNF219 Gene

Relevant External Links for RNF219

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RNF219
genes like me logo Genes that share disorders with RNF219: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF219 Gene

Publications for RNF219 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  3. Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants. (PMID: 24262325) Dichgans M. … . (Stroke 2014) 67
  4. TRIM65 regulates microRNA activity by ubiquitination of TNRC6. (PMID: 24778252) Li S. … Dorf M.E. (Proc. Natl. Acad. Sci. U.S.A. 2014) 67
  5. Autoubiquitination of the 26S proteasome on Rpn13 regulates breakdown of ubiquitin conjugates. (PMID: 24811749) Besche H.C. … Goldberg A.L. (EMBO J. 2014) 67

Products for RNF219 Gene

Sources for RNF219 Gene

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