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Aliases for RNF219 Gene

Aliases for RNF219 Gene

  • Ring Finger Protein 219 2 3
  • C13orf7 3 4
  • Chromosome 13 Open Reading Frame 7 2

External Ids for RNF219 Gene

Previous HGNC Symbols for RNF219 Gene

  • C13orf7

Previous GeneCards Identifiers for RNF219 Gene

  • GC13M078087
  • GC13M079188
  • GC13M059888

Summaries for RNF219 Gene

GeneCards Summary for RNF219 Gene

RNF219 (Ring Finger Protein 219) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF219 Gene

Genomics for RNF219 Gene

Regulatory Elements for RNF219 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RNF219 Gene

78,614,281 bp from pter
78,659,179 bp from pter
44,899 bases
Minus strand

Genomic View for RNF219 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNF219 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF219 Gene

Proteins for RNF219 Gene

  • Protein details for RNF219 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RING finger protein 219
    Protein Accession:
    Secondary Accessions:
    • B2RN99
    • Q8TBY2
    • Q9H0T2
    • Q9H8M0

    Protein attributes for RNF219 Gene

    726 amino acids
    Molecular mass:
    81116 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB14594.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BC028586; Type=Frameshift; Positions=614; Evidence={ECO:0000305}; Sequence=CAB66586.3; Type=Frameshift; Positions=614; Evidence={ECO:0000305};

neXtProt entry for RNF219 Gene

Proteomics data for RNF219 Gene at MOPED

Post-translational modifications for RNF219 Gene

  • Ubiquitination at Lys292 and Lys569
  • Modification sites at PhosphoSitePlus

Other Protein References for RNF219 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RNF219 Gene

Domains for RNF219 Gene

Gene Families for RNF219 Gene

Protein Domains for RNF219 Gene


Suggested Antigen Peptide Sequences for RNF219 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 RING-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF219: view

Function for RNF219 Gene

Gene Ontology (GO) - Molecular Function for RNF219 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with RNF219: view

Animal Model Products

CRISPR Products

miRNA for RNF219 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RNF219 Gene

Localization for RNF219 Gene

Subcellular locations from

Jensen Localization Image for RNF219 Gene COMPARTMENTS Subcellular localization image for RNF219 gene
Compartment Confidence
mitochondrion 2
nucleus 2
cytoskeleton 1
cytosol 1
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RNF219 Gene

Pathways for RNF219 Gene

SuperPathways for RNF219 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for RNF219 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048026 positive regulation of mRNA splicing, via spliceosome IEA --
genes like me logo Genes that share ontologies with RNF219: view

No data available for Pathways by source for RNF219 Gene

Transcripts for RNF219 Gene

Unigene Clusters for RNF219 Gene

Ring finger protein 219:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNF219

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF219 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d
SP1: - - - - - - - -
SP2: - - - - -
SP3: - - -
SP4: - -
SP5: - - - - -
SP6: - - - - - -
SP7: -
SP8: - -

Relevant External Links for RNF219 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNF219 Gene

mRNA expression in normal human tissues for RNF219 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for RNF219 Gene

This gene is overexpressed in Liver, secretome (51.7) and Testis (9.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RNF219 Gene

SOURCE GeneReport for Unigene cluster for RNF219 Gene Hs.567576

genes like me logo Genes that share expressions with RNF219: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for RNF219 Gene

Orthologs for RNF219 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNF219 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RNF219 35
  • 90.19 (n)
  • 90.24 (a)
RNF219 36
  • 90 (a)
(Canis familiaris)
Mammalia RNF219 35
  • 92.24 (n)
  • 92.89 (a)
RNF219 36
  • 93 (a)
(Mus musculus)
Mammalia Rnf219 35
  • 83.1 (n)
  • 81.16 (a)
Rnf219 16
Rnf219 36
  • 81 (a)
(Pan troglodytes)
Mammalia RNF219 35
  • 99.68 (n)
  • 99.59 (a)
RNF219 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Rnf219 35
  • 81.24 (n)
  • 79.94 (a)
(Monodelphis domestica)
Mammalia RNF219 36
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia RNF219 36
  • 68 (a)
(Gallus gallus)
Aves RNF219 35
  • 68.41 (n)
  • 60.68 (a)
RNF219 36
  • 55 (a)
(Anolis carolinensis)
Reptilia RNF219 36
  • 54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf219 35
  • 57.32 (n)
  • 50.3 (a)
(Danio rerio)
Actinopterygii RNF219 36
  • 44 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4956 36
  • 36 (a)
Species with no ortholog for RNF219:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF219 Gene

Gene Tree for RNF219 (if available)
Gene Tree for RNF219 (if available)

Paralogs for RNF219 Gene

No data available for Paralogs for RNF219 Gene

Variants for RNF219 Gene

Sequence variations from dbSNP and Humsavar for RNF219 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs981227 -- 78,618,181(-) AGGAG(A/T)TAAGG intron-variant
rs981228 -- 78,618,036(-) GTTCC(C/T)AGCCC intron-variant
rs1325637 -- 78,630,535(-) gccct(A/G)cccca intron-variant
rs1325638 -- 78,620,651(-) GAGCT(A/G)TTTGG intron-variant
rs1325639 -- 78,619,165(-) CTTTG(A/G)TAGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNF219 Gene

Variant ID Type Subtype PubMed ID
dgv339n67 CNV Gain 20364138
dgv234n27 CNV Loss 19166990
nsv900582 CNV Loss 21882294
nsv1098 CNV Insertion 18451855
dgv340n67 CNV Loss 20364138
esv2667717 CNV Deletion 23128226
esv2747700 CNV Deletion 23290073
esv2421781 CNV Deletion 20811451
nsv442321 CNV CNV 18776908
nsv514712 CNV Loss 21397061
nsv517259 CNV Loss 19592680

Relevant External Links for RNF219 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF219 Gene

Disorders for RNF219 Gene

No disorders were found for RNF219 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for RNF219 Gene

Publications for RNF219 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for RNF219 Gene

Sources for RNF219 Gene

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