RNF219 Gene
protein-coding GIFtS: 43
GCID: GC13M079188
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|
ring finger protein 219(Previous name: chromosome 13 open reading frame 7 )
(Previous symbol: C13orf7)
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Aliases
for RNF219 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ring Finger Protein 2191 2 | | C13orf71 2 3 | | FLJ134491 | | Chromosome 13 Open Reading Frame 71 |
Export aliases for RNF219 gene to outside databasesPrevious GC identifers: GC13M078087 GC13M059888 |
Summaries
for RNF219 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for RNF219 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000013.10 NC_018924.1 NT_024524.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RNF219 gene promoter:
LHX3b/Lhx3b HOXA3 AML1a Pax-2 Ik-3 E47 Pax-2b LHX3a/Lhx3a Hlf
Other transcription factors
Search SABiosciences Chromatin IP Primers for RNF219
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF219 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 13q31.1 Ensembl cytogenetic band: 13q31.1 HGNC cytogenetic band: 13q31.1RNF219 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13M079188: view genomic region
(about GC identifiers)
Start:
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79,188,421 bp from pter |
End:
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79,233,314 bp from pter |
Size:
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44,894 bases |
Orientation:
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minus strand |
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Proteins
for RNF219 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RN219_HUMAN, Q5W0B1 (See
protein sequence)Recommended Name: RING finger protein 219 Size: 726 amino acids; 81116 Da
Sequence caution: Sequence=BAB14594.1; Type=Erroneous initiation; Sequence=BC028586; Type=Frameshift; Positions=614;Sequence=CAB66586.3; Type=Frameshift; Positions=614;
Secondary accessions: B2RN99 Q8TBY2 Q9H0T2 Q9H8M0Explore the universe of human proteins at neXtProt for RNF219: NX_Q5W0B1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5W0B1
RNF219 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_078822.3
ENSEMBL proteins: ENSP00000282003
Human Recombinant Protein Products:
RNF219 Antibody Products:
Assay Products for RNF219: |
Protein
Domains /
Families
for RNF219 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RNF219 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5W0B1ProtoNet protein and cluster: Q5W0B1 UniProtKB/Swiss-Prot: RN219_HUMAN, Q5W0B1Similarity: Contains 1 RING-type zinc finger |
Function
for RNF219 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF219 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF219 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RNF219 (NM_024546) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RNF219 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF219 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF219 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008270 | zinc ion binding |
IEA | -- |
RNF219 for ontologies About GeneDecksing
|
Pathways & Interactions
for RNF219 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNF219
STRING Interaction
Network Preview (showing 5 interactants - click image to see 10)
5/10 Interacting proteins for RNF219 (Q5W0B13 ENSP000002820034) via UniProtKB, MINT, STRING, and/or I2D (see all 10)About this table
|
Drugs & Compounds
for RNF219 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RNF219
Search CenterWatch for drugs/clinical trials and news about RNF219 / RN219
|
Transcripts
for RNF219 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RNF219 gene: NM_024546.3 Unigene Cluster for RNF219: Ring finger protein 219 Hs.567576 [show with all ESTs]Unigene Representative Sequence: CR9367521 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000282003(uc001vkw.1 uc010afb.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF219 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF219 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RNF219 (NM_024546) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RNF219 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF219 |
Additional cDNA sequence: AK023511.1 AK098640.1 AL136651.1 BC028586.1 BC136764.1 BC136765.1 CR936752.1 CR936754.1 CR936764.1 9 DOTS entries: DT.101963493 DT.412951 DT.100767940 DT.95279587 DT.70104829 DT.120795948 DT.120795931 DT.120795845 DT.91998068 24/95 AceView cDNA sequences (see all 95): AA808219 CR591202 AJ243230 BM701567 AA236869 CD108555 BX488506 CB118834 CB146339 AA237068 BQ437398 AK098640 BG741490 AI377424 BM674566 BQ787049 BF940261 BG292548 AA905870 AK023511 BM970618 AL136651 CD656011 BM995757
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for RNF219 (see all 8) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | · | 13c | · | 13d |
|---|
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| SP1: | | | - | | - | | - | | - | | - | | - | | | | - | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | - | | | | - | | | | | | | | | | | | - | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | |
| SP5: | | | | | | | - | | - | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for RNF219
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Expression
for RNF219 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RNF219 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTTTCTATG
About this image
See RNF219 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RNF219
SOURCE GeneReport for Unigene cluster: Hs.567576
SABiosciences Expression via Pathway-Focused PCR Array including RNF219:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNF219
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RNF219 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNF219 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNF219 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF219 |
Orthologs
for RNF219 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for RNF219 gene from 5/15 species (see all 15) About this table
ENSEMBL Gene Tree for RNF219 (if available)
TreeFam Gene Tree for RNF219 (if available) |
Paralogs
for RNF219 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for RNF219 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 13 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RNF219 (79188421 - 79233314 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for RNF219
3 CNVs: 49262 38292 53165 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNF219 |
|
Disorders
/ Diseases
for RNF219 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RNF219 for disorders About GeneDecksing
2  diseases for RNF219: About MalaCardsprostate disease prostatitis
Export disorders for RNF219 gene to outside databases
|
Publications
for RNF219 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RNF219 gene, integrated from 9 sources (see all 21):
(articles sorted by number of sources associating them with RNF219) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Comparative proteomic analysis identifies a role for S UMO in protein quality control. (PubMed id 21693764)1 Tatham M.H....Hay R.T. (2011)
- Genome-wide association of lipid-lowering response to statins in combined study populations. (PubMed id 20339536)1 Barber M.J....Krauss R.M. (2010)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
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External Searches for RNF219 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RNF219 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RNF219 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RNF219 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RNF219 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for RNF219 gene:
Search GeneIP for patents involving RNF219
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RNF219 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RNF219 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RNF219 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNF219 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RNF219 | | OriGene 3'-UTR Clone for RNF219 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF219 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF219 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RNF219 | | OriGene Custom Protein Services for RNF219 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RNF219 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNF219 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF219 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNF219 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNF219 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNF219 |
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| | | | Search Tocris compounds for RNF219 |
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 | | | RNF219 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF219 |
|  |  |  | | | | Search ThermoFisher Antibodies for RNF219 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF219 |
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