RNF217 Gene
protein-coding GIFtS: 45
GCID: GC06P125347
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ring finger protein 217(Previous names: chromosome 6 open reading frame 172, IBR domain containing...)
(Previous symbols: C6orf172, IBRDC1)
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Aliases
for RNF217 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ring Finger Protein 2171 2 3 | | IBR Domain-Containing Protein 12 3 | | C6orf1721 2 3 | | MGC269961 | | IBRDC11 2 3 | | Chromosome 6 Open Reading Frame 1721 | | DJ84N20.11 | | Probable E3 Ubiquitin-Protein Ligase RNF2172 | | IBR Domain Containing 11 2 | | EC 6.3.2.-3 |
Export aliases for RNF217 gene to outside databasesPrevious GC identifer: GC06P122881 |
Summaries
for RNF217 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: RN217_HUMAN, Q8TC41Function: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes in the form of athioester and then directly transfers the ubiquitin to targeted substrates (By similarity)
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Genomic Views
for RNF217 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_025741.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RNF217 gene promoter:
STAT5B Sox5 STAT1 STAT4 STAT1beta STAT6 STAT5A STAT1alpha STAT2 STAT3
Other transcription factors
Search SABiosciences Chromatin IP Primers for RNF217
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF217 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q22.31 Ensembl cytogenetic band: 6q22.31 HGNC cytogenetic band: 6q22.33RNF217 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P125347: view genomic region
(about GC identifiers)
Start:
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125,283,691 bp from pter |
End:
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125,413,779 bp from pter |
Size:
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130,089 bases |
Orientation:
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plus strand |
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Proteins
for RNF217 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RN217_HUMAN, Q8TC41 (See
protein sequence)Recommended Name: Probable E3 ubiquitin-protein ligase RNF217 Size: 275 amino acids; 31981 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Secondary accessions: Q5TCA4 Q9BX48Explore the universe of human proteins at neXtProt for RNF217: NX_Q8TC41
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8TC41
RNF217 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_689766.1
ENSEMBL proteins: ENSP00000428698 ENSP00000429012 ENSP00000427711 ENSP00000357399 ENSP00000352734 ENSP00000404282 ENSP00000452812 ENSP00000275184
Human Recombinant Protein Products for RNF217:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
RNF217 for ontologies About GeneDecksing
RNF217 Antibody Products:
Assay Products for RNF217: |
Protein
Domains /
Families
for RNF217 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RNF217 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8TC41ProtoNet protein and cluster: Q8TC41 1 Blocks protein family: IPB002867 Zn-finger
UniProtKB/Swiss-Prot: RN217_HUMAN, Q8TC41Similarity: Belongs to the RBR family. RNF217 subfamilySimilarity: Contains 1 IBR-type zinc fingerSimilarity: Contains 1 RING-type zinc finger |
Function
for RNF217 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: RN217_HUMAN, Q8TC41Function: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes in the form of athioester and then directly transfers the ubiquitin to targeted substrates (By similarity) Enzyme Number (IUBMB): EC 6.3.2.-1
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004842 | ubiquitin-protein ligase activity |
ISS | -- | | GO:0008270 | zinc ion binding |
IEA | -- |
RNF217 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF217 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF217
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: RNF217 (NM_152553) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RNF217 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF217 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF217 |
|
Pathways & Interactions
for RNF217 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
UniProtKB/Swiss-Prot: RN217_HUMAN, Q8TC41Pathway: Protein modification; protein ubiquitinationInteractions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNF217
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for RNF217 (ENSP000003527344) via UniProtKB, MINT, STRING, and/or I2D About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0042787 | protein ubiquitination involved in ubiquitin-dependent protein catabolic process |
ISS | -- |
RNF217 for ontologies About GeneDecksing
|
Drugs & Compounds
for RNF217 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RNF217
Search CenterWatch for drugs/clinical trials and news about RNF217 / RN217
|
Transcripts
for RNF217 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RNF217 gene: NM_152553.2 Unigene Cluster for RNF217: Ring finger protein 217 Hs.368639 [show with all ESTs]Unigene Representative Sequence: AK12281111 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000521654 ENST00000519971 ENST00000519565 ENST00000454842 ENST00000519799
ENST00000368414(uc003pzt.3) ENST00000359704(uc003pzs.3) ENST00000432158
ENST00000368415 ENST00000560949(uc003pzr.3) ENST00000275184
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF217 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF217
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RNF217 (NM_152553) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RNF217 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF217 |
Additional cDNA sequence: AK057943.1 AK093417.1 AK122811.1 BC026087.2 7 DOTS entries: DT.308701 DT.91703351 DT.97799386 DT.100740023 DT.100683821 DT.100747317 DT.91649449 24/56 AceView cDNA sequences (see all 56): BC026087 BM718471 AK023584 BM985293 BX118513 BQ024056 NM_152553 BP336690 AW469110 AA772709 BM683514 CA436239 CO402490 AI888256 BU752970 BX508707 AW195002 AI310440 BG025210 BE891363 BP335386 BG623134 BP335377 AK093417
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for RNF217 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b |
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| SP1: | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | | | | | | | | | - | | | | | |
ECgene alternative splicing isoforms for RNF217
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Expression
for RNF217 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RNF217 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCGCTACACT
About this image
See RNF217 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RNF217
SOURCE GeneReport for Unigene cluster: Hs.368639
SABiosciences Custom PCR Arrays for RNF217
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNF217
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RNF217 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNF217 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNF217 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF217 |
Orthologs
for RNF217 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for RNF217 gene from 4/13 species (see all 13) About this table
ENSEMBL Gene Tree for RNF217 (if available)
TreeFam Gene Tree for RNF217 (if available) |
Paralogs
for RNF217 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RNF217 gene
- RNF142 RNF19B2 RNF144A2 RNF19A2 RNF144B2
18/63 SIMAP similar genes for RNF217 using alignment to 7 protein entries: RN217_HUMAN (see all proteins)
(see all similar genes):IBRDC1 DCTN5 EML2 C18orf8 PLA2G6 SH3PXD2A
C4orf21 AURA2 LYRM4 PKN1 CFLAR SHANK2
ZNF212 ATP6V0A1 LAMB4 TMEM14B TCEB1 ZDHHC20
RNF217 for paralogs About GeneDecksing
|
Genomic Variants
for RNF217 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RNF217 (125283691 - 125413779 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for RNF217
1 Indel: 59291 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNF217 |
|
Disorders
/ Diseases
for RNF217 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RNF217 for disorders About GeneDecksing
3  diseases for RNF217: About MalaCardscleft lip/palate cleft lip malaria
Human Genome Epidemiology (HuGE) Navigator: RNF217 (2 documents)
Export disorders for RNF217 gene to outside databases
|
Publications
for RNF217 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RNF217 gene integrated from 9 sources:
(articles sorted by number of sources associating them with RNF217) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components. (PubMed id 20682791)1 Gorbea C.... Rechsteiner M. (2010)
- Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PubMed id 18978678)1 Vieira A.R....Marazita M.L. (2008)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for RNF217 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RNF217 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RNF217 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RNF217 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RNF217 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RNF217 gene:
Search GeneIP for patents involving RNF217
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RNF217 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RNF217 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RNF217 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNF217 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RNF217 | | OriGene 3'-UTR Clone for RNF217 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF217 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF217 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | | RNF217 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF217 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for RNF217 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF217 |
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