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RNF216P1 Gene

pseudogene   GIFtS: 24
GCID: GC07P005015

Ring Finger Protein 216 Pseudogene 1

(Previous name: ring finger protein 216-like)
(Previous symbol: RNF216L)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ring Finger Protein 216 Pseudogene 11 2
RNF216L1 2 3
Ring Finger Protein 216-Like1
hCG20405562

External Ids:    HGNC: 336101   Entrez Gene: 4411912   Ensembl: ENSG000001962047   UniProtKB: Q6NUR63   

Export aliases for RNF216P1 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RNF216P1 Gene:
RNF216P1 (ring finger protein 216 pseudogene 1) is a pseudogene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007819.18  
Regulatory elements:
   Search for regulatory transcription factor binding sites for RNF216P1
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNF216P1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22.1   Ensembl cytogenetic band:  7p22.1   HGNC cytogenetic band: 7p22.1

RNF216P1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF216P1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P005015:  view genomic region     (about GC identifiers)

Start:
5,013,616 bp from pter      End:
5,080,306 bp from pter
Size:
66,691 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 5,059,971-5,084,155     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
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UniProtKB/Swiss-Prot: R216L_HUMAN, Q6NUR6 (See protein sequence)
Recommended Name: Putative protein RNF216-like  
Size: 42 amino acids; 5133 Da
Caution: Could be the product of a pseudogene. Highly similar to the N-terminus of RNF216, but may encode a
non-functional truncated protein
Sequence caution: Sequence=BAH14062.1; Type=Erroneous translation; Note=Wrong choice of frame;
Secondary accessions: B7Z8S6

Explore the universe of human proteins at neXtProt for RNF216P1: NX_Q6NUR6

Explore proteomics data for RNF216P1 at MOPED


See RNF216P1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q6NUR6


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Interactions:

    Search GeneGlobe Interaction Network for RNF216P1

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for RNF216P1 (R216L)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Unigene Cluster for RNF216P1:

Ring finger protein 216 pseudogene 1
Hs.520636  [show with all ESTs]
Unigene Representative Sequence: NR_023384
14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000493407 ENST00000406089 ENST00000404404(uc003snp.4 uc003snq.4 uc010ksr.3 uc011jwe.2)
ENST00000477090 ENST00000404006 ENST00000403969 ENST00000494947 ENST00000429902
ENST00000406608 ENST00000405396 ENST00000464479 ENST00000466622 ENST00000471244
ENST00000360944
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Additional mRNA sequence: 

AK303831.1 AK308526.1 AK309798.1 AK311517.1 BC026736.1 BC068459.1 BX538059.1 NR_015449.1 
NR_023384.1 NR_023385.1 

13 DOTS entries:

DT.100822417  DT.95317244  DT.95317260  DT.91757541  DT.97804727  DT.91851452  DT.95317245  DT.95317250 
DT.100822405  DT.75101541  DT.120793368  DT.121112551  DT.95119108 

1 AceView cDNA sequence:

BG985114 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for RNF216P1 (see all 6)    About this scheme

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1:                          -                       -     -                           
SP2:                                                                                    
SP3:                                                  -                                 
SP4:                          -     -     -     -     -     -     -     -               
SP5:                          -                                                         


ECgene alternative splicing isoforms for RNF216P1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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RNF216P1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AAATCCTCAA
RNF216P1 Expression
About this image

RNF216P1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

RNF216P1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.520636
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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ENSEMBL Gene Tree for RNF216P1 (if available)
TreeFam Gene Tree for RNF216P1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for RNF216P1 gene
1 SIMAP similar gene for RNF216P1 using alignment to 1 protein entry:     R216L_HUMAN:
RNF216

Find genes that share paralogs with RNF216P1           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for RNF216P1 (see all 766)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 7 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1503769911,2
--5011634(+) TTGGTG/TCTGGT 3 -- us2k10--------
rs1898078341,2
--5011662(+) AAACAA/GGCCGG 3 -- us2k10--------
rs1808969661,2
C--5011665(+) CAGGCC/TGGGCG 3 -- us2k10--------
rs1851291261,2
--5011669(+) CCGGGC/TGCGGT 3 -- us2k10--------
rs599162941,2
C--5011682(+) CTCACA/GCCTGT 3 -- us2k10--------
rs1423496931,2
--5011810(+) TGGTGA/GCACAT 3 -- us2k10--------
rs1911257711,2
--5011840(+) CAGGAA/GGCTGA 3 -- us2k10--------
rs1459484661,2
--5011851(+) AGCAGG/TAGAAT 3 -- us2k10--------
rs1832678961,2
--5011887(+) GCGGTA/GAGCCG 3 -- us2k10--------
rs126731341,2
C,F,A,H--5011892(+) GAGCCG/AAGACG 3 -- us2k12Minor allele frequency- A:0.50NA 4

HapMap Linkage Disequilibrium report for RNF216P1 (5013616 - 5080306 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for RNF216P1: --
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing RNF216P1
DNA2.0 Custom Variant and Variant Library Synthesis for RNF216P1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for RNF216P1 gene integrated from 10 sources:
(articles sorted by number of sources associating them with RNF216P1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
  3. The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (Nature 2003)
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  5. A novel zinc finger protein interacts with receptor-interacting protein (RIP) and inhibits tumor necrosis factor (TNF)- and IL1- induced NF-kappa B activation. (PubMed id 11854271)1 Chen D.... Shu H.-B. (J. Biol. Chem. 2002)
  6. The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (Science 2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 441191 HGNC: 33610 AceView: LOC441191.1 Ensembl:ENSG00000196204 euGenes: HUgn441191
ECgene: RNF216P1 H-InvDB: RNF216P1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for RNF216P1 gene:
Search GeneIP for patents involving RNF216P1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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