Aliases for RNF216 Gene
External Ids for RNF216 Gene
Previous GeneCards Identifiers for RNF216 Gene
This gene encodes a cytoplasmic protein which specifically colocalizes and interacts with the serine/threonine protein kinase, receptor-interacting protein (RIP). Zinc finger domains of the encoded protein are required for its interaction with RIP and for inhibition of TNF- and IL1-induced NF-kappa B activation pathways. The encoded protein may also function as an E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes and transfers it to substrates. Several alternatively spliced transcript variants have been described for this locus but the full-length natures of only some are known. [provided by RefSeq, Jul 2008]
GeneCards Summary for RNF216 Gene
RNF216 (Ring Finger Protein 216) is a Protein Coding gene. Diseases associated with RNF216 include Cerebellar Ataxia And Hypogonadotropic Hypogonadism and Hypogonadotropism. Among its related pathways are Immune System and protein ubiquitylation. GO annotations related to this gene include ligase activity.
UniProtKB/Swiss-Prot for RNF216 Gene
Isoform 1 acts as an E3 ubiquitin ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Promotes degradation of TRAF3, TLR4 and TLR9. Contributes to the regulation of antiviral responses. Down-regulates activation of NF-kappa-B, IRF3 activation and IFNB production. Isoform 3/ZIN inhibits TNF and IL-1 mediated activation of NF-kappa-B. Promotes TNF and RIP mediated apoptosis.