Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RNF215 Gene

Aliases for RNF215 Gene

  • Ring Finger Protein 215 2 3 5

External Ids for RNF215 Gene

Previous GeneCards Identifiers for RNF215 Gene

  • GC22M029104
  • GC22M030773
  • GC22M013736

Summaries for RNF215 Gene

GeneCards Summary for RNF215 Gene

RNF215 (Ring Finger Protein 215) is a Protein Coding gene. An important paralog of this gene is RNF167.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF215 Gene

Genomics for RNF215 Gene

Regulatory Elements for RNF215 Gene

Enhancers for RNF215 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RNF215 on UCSC Golden Path with GeneCards custom track

Genomic Location for RNF215 Gene

30,368,811 bp from pter
30,421,771 bp from pter
52,961 bases
Minus strand

Genomic View for RNF215 Gene

Genes around RNF215 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF215 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF215 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF215 Gene

Proteins for RNF215 Gene

  • Protein details for RNF215 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RING finger protein 215
    Protein Accession:
    Secondary Accessions:
    • A6NEL1

    Protein attributes for RNF215 Gene

    377 amino acids
    Molecular mass:
    41101 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAD43187.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for RNF215 Gene

Proteomics data for RNF215 Gene at MOPED

Post-translational modifications for RNF215 Gene

  • Glycosylation at Asn 186
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RNF215 Gene

Domains & Families for RNF215 Gene

Gene Families for RNF215 Gene

Protein Domains for RNF215 Gene


Suggested Antigen Peptide Sequences for RNF215 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 RING-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF215: view

Function for RNF215 Gene

genes like me logo Genes that share phenotypes with RNF215: view

Animal Model Products

miRNA for RNF215 Gene

miRTarBase miRNAs that target RNF215

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNF215 Gene

Localization for RNF215 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF215 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for RNF215 Gene COMPARTMENTS Subcellular localization image for RNF215 gene
Compartment Confidence
plasma membrane 2
extracellular 1
golgi apparatus 1

No data available for Gene Ontology (GO) - Cellular Components for RNF215 Gene

Pathways & Interactions for RNF215 Gene

SuperPathways for RNF215 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RNF215 Gene


No data available for Pathways by source and SIGNOR curated interactions for RNF215 Gene

Drugs & Compounds for RNF215 Gene

No Compound Related Data Available

Transcripts for RNF215 Gene

mRNA/cDNA for RNF215 Gene

Unigene Clusters for RNF215 Gene

Ring finger protein 215:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNF215 Gene

No ASD Table

Relevant External Links for RNF215 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNF215 Gene

mRNA expression in normal human tissues for RNF215 Gene

Protein differential expression in normal tissues from HIPED for RNF215 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RNF215 Gene

SOURCE GeneReport for Unigene cluster for RNF215 Gene Hs.592194

genes like me logo Genes that share expression patterns with RNF215: view

Protein tissue co-expression partners for RNF215 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RNF215 Gene

Orthologs for RNF215 Gene

This gene was present in the common ancestor of animals.

Orthologs for RNF215 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RNF215 35
  • 89.83 (n)
  • 93.4 (a)
RNF215 36
  • 91 (a)
(Canis familiaris)
Mammalia RNF215 35
  • 91.3 (n)
  • 94.78 (a)
RNF215 36
  • 66 (a)
(Mus musculus)
Mammalia Rnf215 35
  • 86.33 (n)
  • 90.86 (a)
Rnf215 16
Rnf215 36
  • 90 (a)
(Pan troglodytes)
Mammalia RNF215 35
  • 99.29 (n)
  • 99.29 (a)
RNF215 36
  • 95 (a)
(Rattus norvegicus)
Mammalia Rnf215 35
  • 86.23 (n)
  • 92.04 (a)
(Monodelphis domestica)
Mammalia RNF215 36
  • 48 (a)
(Ornithorhynchus anatinus)
Mammalia RNF215 36
  • 60 (a)
(Gallus gallus)
Aves RNF215 35
  • 67.64 (n)
  • 57.82 (a)
RNF215 36
  • 44 (a)
(Anolis carolinensis)
Reptilia RNF215 36
  • 40 (a)
(Danio rerio)
Actinopterygii si:ch211-188g24.2 35
  • 58.49 (n)
  • 50.57 (a)
RNF215 36
  • 37 (a)
(Caenorhabditis elegans)
Secernentea Y47D3B.11 36
  • 14 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
Species with no ortholog for RNF215:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RNF215 Gene

Gene Tree for RNF215 (if available)
Gene Tree for RNF215 (if available)

Paralogs for RNF215 Gene

(3) SIMAP similar genes for RNF215 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with RNF215: view

Variants for RNF215 Gene

Sequence variations from dbSNP and Humsavar for RNF215 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs5749088 - 30,380,106(+) CTCAG(C/T)ACCCG reference, missense
rs7289360 -- 30,388,122(+) CTAAA(A/C)ATACA upstream-variant-2KB
rs7292744 -- 30,384,735(+) GCCAC(C/T)TCCTT intron-variant
rs34082048 -- 30,389,292(+) GCTAA(-/T)TTTTT upstream-variant-2KB
rs34164063 -- 30,381,527(+) ACGCT(-/C)CCCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNF215 Gene

Variant ID Type Subtype PubMed ID
nsv829171 CNV Loss 20364138
nsv914970 CNV Loss 21882294

Variation tolerance for RNF215 Gene

Residual Variation Intolerance Score: 68.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.05; 50.49% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RNF215 Gene

Disorders for RNF215 Gene

Relevant External Links for RNF215

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RNF215 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF215 Gene

Publications for RNF215 Gene

  1. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 4 67
  2. Toward a complete human genome sequence. (PMID: 9847074) Sulston J.E. … Waterston R. (Genome Res. 1998) 3

Products for RNF215 Gene

Sources for RNF215 Gene