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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RNF215 Gene

protein-coding GIFtS: 39
GCID: GC22M030773

ring finger protein 215

Search for RNF215
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ring Finger Protein 215¹ ²

External Ids:	HGNC: 33434¹	Entrez Gene: 200312²	Ensembl: ENSG00000099999⁷	UniProtKB: Q9Y6U7³

Export aliases for RNF215 gene to outside databases

Previous GC identifers: GC22M029104 GC22M013736

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000022.10 NC_018933.1 NT_011520.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RNF215 gene promoter:
AP-2alpha isoform 3 AP-2alpha isoform 2 AP-2alpha AP-2alphaA
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RNF215 promoter sequence

Search SABiosciences Chromatin IP Primers for RNF215

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF215

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.2 Ensembl cytogenetic band: 22q12.2 HGNC cytogenetic band: 22q12.2

RNF215 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF215 gene location

GeneLoc information about chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22M030773: view genomic region (about GC identifiers)

Start:	30,773,808 bp from pter	End:	30,817,760 bp from pter
Size:	43,953 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RN215_HUMAN, Q9Y6U7 (See protein sequence)

Recommended Name: RING finger protein 215

Size: 377 amino acids; 41101 Da

Subcellular location: Membrane; Multi-pass membrane protein (Potential)

Sequence caution: Sequence=AAD43187.1; Type=Erroneous gene model prediction;

Secondary accessions: A6NEL1

Explore the universe of human proteins at neXtProt for RNF215: NX_Q9Y6U7

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9Y6U7

RNF215 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001017981.1

ENSEMBL proteins:

ENSP00000419343 ENSP00000419630 ENSP00000419318 ENSP00000396278 ENSP00000371800

ENSP00000215798 ENSP00000404738

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	IEA	--

RNF215 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RNF215 for domains About GeneDecksing

2 InterPro domains/families:

IPR001841 Znf_RING

IPR013083 Znf_RING/FYVE/PHD

Graphical View of Domain Structure for InterPro Entry Q9Y6U7

ProtoNet protein and cluster: Q9Y6U7

UniProtKB/Swiss-Prot: RN215_HUMAN, Q9Y6U7

Similarity: Contains 1 RING-type zinc finger

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008270	zinc ion binding	IEA	--

RNF215 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for RNF215

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for RNF215 gene:

NM_001017981.1

Unigene Cluster for RNF215:

Ring finger protein 215

Hs.592194 [show with all ESTs]

Unigene Representative Sequence: NM_001017981

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000478314 ENST00000469245 ENST00000469933 ENST00000421022 ENST00000382363(uc011akw.2 uc003ahp.3)

ENST00000215798 ENST00000463319 ENST00000473077 ENST00000431544

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Additional cDNA sequence: AK293904.1

3 DOTS entries:

DT.70103525 DT.92057027 DT.439908

24/40 AceView cDNA sequences (see all 40):

CD243800 AB051443 CA488730 BM806918 BQ955099 AA983959 BX279849 CR456347

BM476400 BQ890035 BI766192 BX279583 AA724729 BM768497 BX494669 BM673690

AW168271 BF981374 BQ686946 BQ370334 BC035861 CB048153 BM686848 BF950436

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RNF215 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGTCCCACTG

About this image

RNF215 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See RNF215 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RNF215

SOURCE GeneReport for Unigene cluster: Hs.592194

SABiosciences Expression via Pathway-Focused PCR Array including RNF215:

Ubiquitin Ligases in human mouse rat

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for RNF215 gene from 5/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	RNF215¹	ring finger protein 215	65.08(n) 53.71(a)		417009 XM_415299.3 XP_415299.2
lizard (Anolis carolinensis)	Reptilia	RNF215⁶	--	43(a)	1 ↔ 1	GL343417.1(129406-133015)
zebrafish (Danio rerio)	Actinopterygii	si:ch211-188g24.2⁶	si:ch211-188g24.2	36(a)	1 ↔ 1	5(19662208-19668188)
worm (Caenorhabditis elegans)	Secernentea	Y47D3B.11⁶	Protein Y47D3B.11	13(a)	1 → many	III(11456777-11462782)
rice (Oryza sativa)	Liliopsida	--	zinc finger, C3HC4 type domain containing protein	35(a)	1 → many	12(26391264-26391518)

ENSEMBL Gene Tree for RNF215 (if available)
TreeFam Gene Tree for RNF215 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RNF215 gene

ZNRF3² RNF167² RNF130² RNF150² RNF148² RNF43² RNF128² RNF149²

ZNRF4² RNF13² RNF133²

3 SIMAP similar genes for RNF215 using alignment to 4 protein entries: RN215_HUMAN (see all proteins):

RNF43 RNF150 LOC284996

RNF215 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 22 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs5749088^1,2	C,F,H,	--	30776095(+)	`CTCAGC/TACCCG`	2	T A	mis¹ ese³		24		NS EA NA EU	8284
rs145936896^1,2	C,	--	30776103(+)	`CCGGAT/CCTGGG`	2	/D /G	mis¹		1		NA	4346
rs139785680^1,2	C,F,	--	30776106(+)	`GATCTG/CGGAGG`	2	/P /R	mis¹		2		NA EU	5625
rs146126721^1,2	C,	--	30776122(+)	`CGCTGC/ACCTGC`	2	/A /S	mis¹		1		NA	4132
rs201785934^1,2		--	30776129(+)	`CTGCTC/TAGCCG`	2	L	syn¹		0	--	--	--	--
rs139847547^1,2	C	--	30776139(+)	`GGCAGC/TGCCGT`	2	H R	mis¹		1		NA	3796
rs142215295^1,2	C,	--	30776173(+)	`CACCAC/TGCGGC`	2	M V	mis¹		0	--	--	--	--
rs200669114^1,2		--	30776199(+)	`CCTGTC/GGGGAG`	1	--	int¹		0	--	--	--	--
rs148531088^1,2	F	--	30776301(+)	`TGCCGC/TGACGC`	2	S	syn¹		1		NA	3898
rs145390086^1,2	C	--	30776311(+)	`CCTGCC/TGCTGG`	2	Q R	mis¹		2		NA EU	5077

HapMap Linkage Disequilibrium report for RNF215 (30773808 - 30817760 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RNF215: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for RNF215 gene integrated from 9 sources:
(articles sorted by number of sources associating them with RNF215)

Utopia: connect your pdf to the dynamic
world of online information

The DNA sequence of human chromosome 22. (PubMed id 10591208)² Dunham I....O'Brien K.P. (1999)
Toward a complete human genome sequence. (PubMed id 9847074)¹ Wilson R. (1998)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 200312	HGNC: 33434	AceView: LOC200312	Ensembl:ENSG00000099999	euGenes: HUgn200312
ECgene: RNF215	H-InvDB: RNF215

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for RNF215	Pharmacogenomics, SNPs, Pathways

Intellectual Property for RNF215 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for RNF215 gene:
Search GeneIP for patents involving RNF215

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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About This Section


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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes RNF215 gene at Home site.

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RNF215 Gene

ring finger protein 215

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RNF215 Gene

ring finger protein 215

Aliasesfor RNF215 gene

Summariesfor RNF215 gene

Genomic Viewsfor RNF215 gene

Proteinsfor RNF215 gene

Protein Domains /Familiesfor RNF215 gene

Functionfor RNF215 gene

Pathways & Interactionsfor RNF215 gene

Drugs & Compoundsfor RNF215 gene

Transcriptsfor RNF215 gene

Expression for RNF215 gene

Orthologsfor RNF215 gene

Paralogsfor RNF215 gene

Genomic Variantsfor RNF215 gene

Disorders / Diseasesfor RNF215 gene

Publicationsfor RNF215 gene

External Searches for RNF215 gene

Genome Databases showing RNF215 gene

Other Databases showing RNF215 gene

Specialized Databases showing RNF215 gene

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Productsfor RNF215 gene

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Aliases
for RNF215 gene

Summaries
for RNF215 gene

Genomic Views
for RNF215 gene

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for RNF215 gene

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for RNF215 gene

Function
for RNF215 gene

Pathways & Interactions
for RNF215 gene

Drugs & Compounds
for RNF215 gene

Transcripts
for RNF215 gene

Expression
for RNF215 gene

Orthologs
for RNF215 gene

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for RNF215 gene

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for RNF215 gene

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for RNF215 gene

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for RNF215 gene

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for RNF215 gene

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for RNF215 gene