RNF214 Gene
protein-coding GIFtS: 45
GCID: GC11P117104
|
|
ring finger protein 214
| |
Aliases
for RNF214 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ring Finger Protein 2141 2 | | DKFZp547C1951 |
Export aliases for RNF214 gene to outside databasesPrevious GC identifers: GC11P116609 GC11P113036 |
Summaries
for RNF214 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for RNF214 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_033899.8
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RNF214 gene promoter:
AML1a
Other transcription factors
Search SABiosciences Chromatin IP Primers for RNF214
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF214 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q23.3 Ensembl cytogenetic band: 11q23.3 HGNC cytogenetic band: 11q23.3RNF214 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P117104: view genomic region
(about GC identifiers)
Start:
|
117,103,341 bp from pter |
End:
|
117,157,161 bp from pter |
Size:
|
53,821 bases |
Orientation:
|
plus strand |
|
Proteins
for RNF214 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RN214_HUMAN, Q8ND24 (See
protein sequence)Recommended Name: RING finger protein 214 Size: 703 amino acids; 77667 Da
Secondary accessions: B2RUW0Explore the universe of human proteins at neXtProt for RNF214: NX_Q8ND24
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8ND24
RNF214 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001070707.1 NP_997226.2
ENSEMBL proteins: ENSP00000434186 ENSP00000435361 ENSP00000431643 ENSP00000432903 ENSP00000300650
Human Recombinant Protein Products:
RNF214 Antibody Products:
Assay Products for RNF214: |
Protein
Domains /
Families
for RNF214 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RNF214 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8ND24ProtoNet protein and cluster: Q8ND24 1 Blocks protein family: IPB001841 Zn-finger
UniProtKB/Swiss-Prot: RN214_HUMAN, Q8ND24Similarity: Contains 1 RING-type zinc finger |
Function
for RNF214 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF214 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF214 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): RNF214 (NM_001077239) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RNF214 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF214 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF214 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008270 | zinc ion binding |
IEA | -- |
RNF214 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for RNF214:
|
Pathways & Interactions
for RNF214 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNF214
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
2 Interacting proteins for RNF214 (Q8ND243 ENSP000003006504) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for RNF214 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RNF214
Search CenterWatch for drugs/clinical trials and news about RNF214 / RN214
|
Transcripts
for RNF214 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RNF214 gene (2 alternative transcripts): NM_001077239.1 NM_207343.2 Unigene Cluster for RNF214: Ring finger protein 214 Hs.591934 [show with all ESTs]Unigene Representative Sequence: NM_0010772398 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000534428 ENST00000529869 ENST00000531287 ENST00000531452(uc001pqt.3 uc001pqu.3 uc010rxf.2)
ENST00000530849 ENST00000524917 ENST00000534709 ENST00000300650
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF214 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF214 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): RNF214 (NM_001077239) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RNF214 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF214 |
Additional cDNA sequence: AK298923.1 AK300160.1 AL834448.1 BC031347.1 BC064581.1 BC146891.1 BC146901.1 7 DOTS entries: DT.95289355 DT.442123 DT.120701571 DT.100774642 DT.97779002 DT.97834575 DT.91643276 24/94 AceView cDNA sequences (see all 94): AI151014 BM996401 AA629249 CK904823 CA423729 AI472598 BC064581 BQ221642 BE328485 CR624116 CB152535 BU618691 BC031347 AI951346 BX330939 BX390413 BF437757 CD742563 BQ684591 BM055358 AV652165 BX380743 NM_207343 H00530
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for RNF214 (see all 8) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | · | 13c | · | 13d | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b |
|---|
|
| SP1: | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | |
ECgene alternative splicing isoforms for RNF214
|
Expression
for RNF214 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RNF214 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATGCAGATT
About this image
See RNF214 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RNF214
SOURCE GeneReport for Unigene cluster: Hs.591934
SABiosciences Custom PCR Arrays for RNF214
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNF214
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RNF214 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNF214 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNF214 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF214 |
Orthologs
for RNF214 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for RNF214 gene from 2/10 species (see all 10) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
RNF2141 |
ring finger protein 214 |
75.87(n)
83.23(a) |
|
419767 XM_417907.3 XP_417907.3 |
zebrafish
(Danio rerio) |
Actinopterygii |
si:ch211-139a5.11 |
si:ch211-139a5.1 |
51.75(n)
40.79(a) |
|
794287 XM_001334185.3 XP_001334221.2 |
ENSEMBL Gene Tree for RNF214 (if available)
TreeFam Gene Tree for RNF214 (if available) |
Paralogs
for RNF214 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RNF214 gene
- TTC32 DZIP32
RNF214 for paralogs About GeneDecksing
|
Genomic Variants
for RNF214 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RNF214 (117103341 - 117157161 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for RNF214
2 CNVs: 48703 48702 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNF214 |
|
Disorders
/ Diseases
for RNF214 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RNF214 for disorders About GeneDecksing
1  disease for RNF214: About MalaCardsmigraine
Export disorders for RNF214 gene to outside databases
|
Publications
for RNF214 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RNF214 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with RNF214) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Genetic determinants of cardiovascular events among w omen with migraine: a genome-wide association study. (PubMed id 21779381)1 SchA1rks M....Kurth T. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Activity-based chemical proteomics accelerates inhibi tor development for deubiquitylating enzymes. (PubMed id 22118674)1 Altun M....Kessler B.M. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
|
External Searches for RNF214 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RNF214 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RNF214 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RNF214 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RNF214 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RNF214 gene:
Search GeneIP for patents involving RNF214
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RNF214 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RNF214 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RNF214 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNF214 | | | OriGene Protein Over-expression Lysate for RNF214 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RNF214 | | OriGene 3'-UTR Clone for RNF214 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF214 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF214 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RNF214 | | OriGene Custom Protein Services for RNF214 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RNF214 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNF214 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF214 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNF214 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNF214 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNF214 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for RNF214 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF214 |
|  |  |  | | | | ThermoFisher Antibodies for RNF214 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF214 |
|
|
|
|
