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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RNF213 Gene

protein-coding   GIFtS: 54
GCID: GC17P078235

Ring Finger Protein 213

(Previous names: chromosome 17 open reading frame 27, KIAA1618, moyamoya...)
(Previous symbols: C17orf27, KIAA1618, MYMY2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ring Finger Protein 2131 2 3     Moyamoya Disease 21
C17orf271 2 3     NET572
KIAA16181 2 3     E3 Ubiquitin-Protein Ligase RNF2132
MYMY21 2     mysterin2
ALO172 3     EC 6.3.2.-3
MYSTR2 3     KIAA15543
ALK Lymphoma Oligomerization Partner On Chromosome 172 3     Mysterin3
Chromosome 17 Open Reading Frame 271     

External Ids:    HGNC: 145391   Entrez Gene: 576742   Ensembl: ENSG000001738217   OMIM: 6137685   UniProtKB: Q63HN83   

Export aliases for RNF213 gene to outside databases

Previous GC identifers: GC17P075929 GC17P078313 GC17P073677


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RNF213 Gene:
This gene encodes a protein containing a C3HC4-type RING finger domain, which is a specialized type of Zn-finger
that binds two atoms of zinc and is thought to be involved in mediating protein-protein interactions. The protein
also contains an AAA domain, which is associated with ATPase activity. This gene is a susceptibility gene for
Moyamoya disease, a vascular disorder of intracranial arteries. This gene is also a translocation partner in
anaplastic large cell lymphoma and inflammatory myofibroblastic tumor cases, where a t(2;17)(p23;q25)
translocation has been identified with the anaplastic lymphoma kinase (ALK) gene on chromosome 2, and a
t(8;17)(q24;q25) translocation has been identified with the MYC gene on chromosome 8. Alternative splicing
results in multiple transcript variants. (provided by RefSeq, Dec 2011)

GeneCards Summary for RNF213 Gene: 
RNF213 (ring finger protein 213) is a protein-coding gene. Diseases associated with RNF213 include inflammatory myofibroblastic tumor, and moyamoya disease. GO annotations related to this gene include ATPase activity and nucleotide binding.

UniProtKB/Swiss-Prot: RN213_HUMAN, Q63HN8
Function: Probable E3 ubiquitin-protein ligase that may play a role in angiogenesis. May also have an ATPase
activity

Gene Wiki entry for RNF213 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RNF213 gene promoter:
         HOXA9B   HOXA9   Max1   GR   Sp1   GR-beta   C/EBPalpha   FOXC1   GR-alpha   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RNF213 promoter sequence
   Search SABiosciences Chromatin IP Primers for RNF213

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF213


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.3   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25.3

RNF213 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF213 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P078235:  view genomic region     (about GC identifiers)

Start:
78,234,665 bp from pter      End:
78,372,586 bp from pter
Size:
137,922 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RN213_HUMAN, Q63HN8 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase RNF213  
Size: 5207 amino acids; 591407 Da
Subcellular location: Cytoplasm
Sequence caution: Sequence=AAH32220.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAB13444.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact; Sequence=BAB14708.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB15212.1; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=BAB15280.1; Type=Erroneous termination;
Positions=4257; Note=Translated as Gln; Sequence=BAB15330.1; Type=Erroneous initiation; Note=Translation
N-terminally extended; Sequence=CAH10615.1; Type=Frameshift; Positions=211, 213, 221, 266; Sequence=CAH56189.1;
Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: C9JCP4 D6RI12 F8WKS1 Q658P6 Q69YK7 Q6MZR1 Q8IWF4 Q8IZX1 Q8IZX2 Q8N406
Q8TEU0 Q9H6C9 Q9H6H9 Q9H6P3 Q9H8A9 Q9HCF4 Q9HCL8
Alternative splicing: 4 isoforms:  Q63HN8-3   Q63HN8-4   Q63HN8-5   Q63HN8-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RNF213: NX_Q63HN8

Explore proteomics data for RNF213 at MOPED 

Post-translational modifications:

  • UniProtKB: Autoubiquitinates
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q63HN8

  • RNF213 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RNF213 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001243000.1  NP_066005.2  

    ENSEMBL proteins: 
     ENSP00000425956   ENSP00000464087   ENSP00000324392   ENSP00000460462   ENSP00000392123  
     ENSP00000338218  

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    Cloud-Clone Corp. Proteins for RNF213 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--

    RNF213 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RNF: RING-type (C3HC4) zinc fingers

    5 InterPro protein domains:
     IPR001841 Znf_RING
     IPR027417 P-loop_NTPase
     IPR003593 AAA+_ATPase
     IPR018957 Znf_C3HC4_RING-type
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q63HN8

    ProtoNet protein and cluster: Q63HN8

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: RN213_HUMAN, Q63HN8
    Domain: The RING-type zinc finger domain is required for the ubiquitin-protein ligase activity
    Similarity: Contains 1 RING-type zinc finger


    RNF213 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RN213_HUMAN, Q63HN8
    Function: Probable E3 ubiquitin-protein ligase that may play a role in angiogenesis. May also have an ATPase
    activity

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0004842ubiquitin-protein ligase activity IDA--
    GO:0005515protein binding ----
    GO:0005524ATP binding ----
    GO:0008270zinc ion binding IEA--
         
    RNF213 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for RNF213:
     G2 arrest  Increased G2M DNA content  Synthetic lethal with paclitax 

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidRNF213 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    UniProtKB/Swiss-Prot: RN213_HUMAN, Q63HN8
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNF213

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for RNF213 (Q63HN83 ENSP000003382184) via UniProtKB, MINT, STRING, and/or I2D

    InteractantInteraction Details
    GeneCardExternal ID(s)
    MCRS1Q96EZ83I2D: score=1 
    --ensp: ENSP000003243924STRING: ensp: ENSP00000324392
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006200ATP catabolic process IDA--
    GO:0016567protein ubiquitination IDA--
    GO:0051865protein autoubiquitination IDA--

    RNF213 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RNF213 (RN213)

    Search CenterWatch for drugs/clinical trials and news about RNF213 / RN213

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RNF213 gene (3 alternative transcripts): 
    NM_001256071.1  NM_020954.3  NM_020914.4  

    Unigene Clusters for RNF213:

    Ring finger protein 213
    Hs.195642  [show with all ESTs], Hs.740662  [show with all ESTs]
    Unigene Representative Sequences: BX647946, NM_001256071
    18/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000508628 ENST00000582970(uc002jyh.2 uc021uen.1) ENST00000319921(uc002jyf.3)
    ENST00000559070(uc002jyg.1) ENST00000573548 ENST00000574060 ENST00000571908
    ENST00000558116 ENST00000560694 ENST00000558488 ENST00000559603 ENST00000411702
    ENST00000573038 ENST00000559864 ENST00000574909 ENST00000572622 ENST00000427003
    ENST00000570776
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidRNF213 3' UTR sequence
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    Additional mRNA sequence: 

    AB046838.1 AB537889.1 AF397204.1 AF397205.1 AK023113.1 AL832920.1 BC035987.1 BC036891.1 
    BC040341.1 

    24/43 DOTS entries (see all 43):

    DT.447919  DT.91848111  DT.406466  DT.95295507  DT.97796434  DT.97826493  DT.75162914  DT.120997484 
    DT.95295580  DT.100010838  DT.91701159  DT.106896  DT.95221882  DT.100745287  DT.306845  DT.40189773 
    DT.91819678  DT.92454782  DT.95124682  DT.95295572  DT.95365281  DT.120948996  DT.120997554  DT.92454778 

    2 AceView cDNA sequences:

    BI019105 BI049835 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RNF213 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGCCACCAG
    RNF213 Expression
    About this image


    See RNF213 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RNF213

    SOURCE GeneReport for Unigene clusters: Hs.195642 Hs.740662

    UniProtKB/Swiss-Prot: RN213_HUMAN, Q63HN8
    Tissue specificity: Widely expressed (at protein level)

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF213

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for RNF213 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves RNF2136
    ring finger protein 213
    31(a)
    1 ↔ 1
    18(9771940-9818172)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    30(a)
    26(a)
    many → 1
    many → 1
    2(100362209-100436514)
    GL344242.1(608-48147)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480423552   -- 77.88(n)    48042355 
    zebrafish
    (Danio rerio)
    Actinopterygii RNF213 (2 of 3)6
    RNF213 (3 of 3)6
    (see all 4)
    ring finger protein 213
    (see all 4)
    7(a)
    46(a)
    (see all 4)
    many → 1
    many → 1
    (see all 4)
    Zv9_NA510(4047-15172)
    3(9692281-9697712)
            Species with no ortholog for RNF213

    ENSEMBL Gene Tree for RNF213 (if available)
    TreeFam Gene Tree for RNF213 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2751 SNPs in RNF213 are shown (see all 2751)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0670304
    Moyamoya disease 2 (MYMY2)4--see VAR_0670302 R K mis40--------
    VAR_0670224
    ----see VAR_0670222 E G mis40--------
    VAR_0670284
    ----see VAR_0670282 P S mis40--------
    VAR_0670254
    ----see VAR_0670252 R Q mis40--------
    VAR_0670344
    ----see VAR_0670342 D E mis40--------
    VAR_0670314
    ----see VAR_0670312 D N mis40--------
    VAR_0670234
    ----see VAR_0670232 N D mis40--------
    VAR_0670244
    ----see VAR_0670242 D N mis40--------
    VAR_0670324
    ----see VAR_0670322 E D mis40--------
    VAR_0670294
    ----see VAR_0670292 V M mis40--------

    HapMap Linkage Disequilibrium report for RNF213 (78234665 - 78372586 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/26 variations for RNF213 (see all 26):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2473168CNV Deletion19546169
    esv2311590CNV Deletion18987734
    esv2716373CNV Deletion23290073
    dgv471e201CNV Deletion23290073
    esv2716371CNV Deletion23290073
    esv2166847CNV Deletion18987734
    esv2716377CNV Deletion23290073
    nsv821604CNV Deletion20802225
    esv2716376CNV Deletion23290073
    esv2716370CNV Deletion23290073


    Human Gene Mutation Database (HGMD): RNF213
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 613768    OMIM disorders: --

    UniProtKB/Swiss-Prot: RN213_HUMAN, Q63HN8
  • Moyamoya disease 2 (MYMY2) [MIM:607151]: A progressive cerebral angiopathy characterized by bilateral
    intracranial carotid artery stenosis and telangiectatic vessels in the region of the basal ganglia. The abnormal
    vessels resemble a 'puff of smoke' (moyamoya) on cerebral angiogram. Affected individuals can develop transient
    ischemic attacks and/or cerebral infarction, and rupture of the collateral vessels can cause intracranial
    hemorrhage. Hemiplegia of sudden onset and epileptic seizures constitute the prevailing presentation in
    childhood, while subarachnoid bleeding occurs more frequently in adults. Note=Disease susceptibility is
    associated with variations affecting the gene represented in this entry
  • Note=A chromosomal aberration involving ALO17 is associated with anaplastic large-cell lymphoma (ALCL).
    Translocation t(2;17)(p23;q25) with ALK

  • 7 diseases for RNF213:    About MalaCards
    inflammatory myofibroblastic tumor    moyamoya disease    anaplastic large cell lymphoma    hemiplegia
    cerebral infarction    autism spectrum disorder    cerebritis

    1 disease from the University of Copenhagen DISEASES database for RNF213:
    Moyamoya disease

    RNF213 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RNF213
    Human Genome Epidemiology (HuGE) Navigator: RNF213 (1 document)

    Export disorders for RNF213 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RNF213 gene, integrated from 9 sources (see all 37):
    (articles sorted by number of sources associating them with RNF213)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A genome-wide association study identifies RNF213 as the first Moyamoya disease gene. (PubMed id 21048783)1, 2, 3, 4 Kamada F....Kure S. (2010)
    2. Identification of RNF213 as a Susceptibility Gene for Moyamoya Disease and Its Possible Role in Vascular Development. (PubMed id 21799892)1, 2, 3 Liu W....Koizumi A. (2011)
    3. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)1, 2, 3 Nagase T.... Ohara O. (2000)
    4. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)1, 2 Dephoure N.... Gygi S.P. (2008)
    5. Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography. (PubMed id 18318008)1, 2 Han G.... Gu J. (2008)
    6. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)1, 2 Bechtel S.... Schupp I. (2007)
    7. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)1, 2 Zody M.C.... Nusbaum C. (2006)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Identification of novel fusion partners of ALK, the anaplastic lymphoma kinase, in anaplastic large-cell lymphoma and inflammatory myofibroblastic tumor. (PubMed id 12112524)1, 2 Cools J.... Marynen P. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57674 HGNC: 14539 AceView: C17orf27 Ensembl:ENSG00000173821 euGenes: HUgn57674
    ECgene: RNF213 H-InvDB: RNF213

    (According to HUGE)
    About This Section
    HUGE: KIAA1618 KIAA1554

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RNF213 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RNF213 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RNF213 gene:
    Search GeneIP for patents involving RNF213

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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