RNF212 Gene
protein-coding GIFtS: 44
GCID: GC04M001057
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|
ring finger protein 212(Previous name: hypothetical protein LOC285498 )
(Previous symbol: LOC285498)
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Aliases
for RNF212 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ring Finger Protein 2121 2 3 | | ZHP32 5 | | FLJ388411 | | LOC2854981 | | Hypothetical Protein LOC2854981 | | EC 6.3.2.-3 |
Export aliases for RNF212 gene to outside databases |
Summaries
for RNF212 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RNF212:
This gene encodes a RING finger protein that may function as a ubiquitin ligase. The encoded protein may be involved inmeiotic recombination. This gene is located within a linkage disequilibrium block and polymorphisms in this gene mayinfluence recombination rates. Alternate splicing results in multiple transcript variants.(provided by RefSeq, Oct2010)
UniProtKB/Swiss-Prot: RN212_HUMAN, Q495C1Function: Key regulator of crossing-over during meiosis: required to couple chromosome synapsis to the formation ofcrossover-specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specificrecombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May act as a SUMO E3 ligase thatmediates sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites.Acts as a limiting factor for crossover designation and/or reinforcement (By similarity)
|
Genomic Views
for RNF212 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_037622.5
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RNF212 gene promoter:
SRF Tal-1 AP-1 SRF (504 AA) E4BP4 E47 c-Ets-1 FOXO1a ZID FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for RNF212
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF212 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4p16.3 Ensembl cytogenetic band: 4p16.3 HGNC cytogenetic band: 4p16.3RNF212 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M001057: view genomic region
(about GC identifiers)
Start:
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1,050,038 bp from pter |
End:
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1,107,582 bp from pter |
Size:
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57,545 bases |
Orientation:
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minus strand |
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Proteins
for RNF212 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RN212_HUMAN, Q495C1 (See
protein sequence)Recommended Name: Probable E3 SUMO-protein ligase RNF212 Size: 297 amino acids; 33365 Da
Subcellular location: Nucleus (By similarity). Chromosome (By similarity). Note=Associates to the synaptonemal complex.Localizes to a minority of double-strand breaks (DSBs) sites. Marks crossover sites during midpachynema (Bysimilarity)
Secondary accessions: C9J8N0 Q495C0 Q86W82 Q8IY99 Q8N8U7Alternative splicing: 6 isoforms: Q495C1-1 Q495C1-2 Q495C1-3 Q495C1-4 Q495C1-5 Q495C1-6 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for RNF212: NX_Q495C1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q495C1
RNF212 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001124506.1 NP_001180247.1 NP_919420.1
ENSEMBL proteins: ENSP00000425843 ENSP00000372428 ENSP00000389709 ENSP00000426115 ENSP00000423030 ENSP00000423560 ENSP00000327481
Human Recombinant Protein Products for RNF212:
RNF212 Antibody Products:
Assay Products for RNF212: |
Protein
Domains /
Families
for RNF212 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RNF212 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q495C1ProtoNet protein and cluster: Q495C1 UniProtKB/Swiss-Prot: RN212_HUMAN, Q495C1Similarity: Contains 1 RING-type zinc finger |
Function
for RNF212 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: RN212_HUMAN, Q495C1Function: Key regulator of crossing-over during meiosis: required to couple chromosome synapsis to the formation ofcrossover-specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specificrecombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May act as a SUMO E3 ligase thatmediates sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites.Acts as a limiting factor for crossover designation and/or reinforcement (By similarity) Enzyme Number (IUBMB): EC 6.3.2.-1
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008270 | zinc ion binding |
IEA | -- |
RNF212 for ontologies About GeneDecksing
Phenotypes:
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Rnf212):
RNF212 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Rnf212tm1Nhtr for RNF212
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF212 (see all 2)
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Synthesis Service for RNF212 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF212 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF212 |
|
Pathways & Interactions
for RNF212 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
UniProtKB/Swiss-Prot: RN212_HUMAN, Q495C1Pathway: Protein modification; protein sumoylationInteractions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNF212
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for RNF212 (ENSP000003897094) via UniProtKB, MINT, STRING, and/or I2D About this table
|
Drugs & Compounds
for RNF212 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RNF212
Search CenterWatch for drugs/clinical trials and news about RNF212 / RN212
|
Transcripts
for RNF212 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RNF212 gene (3 alternative transcripts): NM_001131034.3 NM_001193318.2 NM_194439.4 Unigene Cluster for RNF212: Ring finger protein 212 Hs.248290 [show with all ESTs]Unigene Representative Sequence: XR_17144315 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000514024(uc021xkg.1) ENST00000514757 ENST00000505693 ENST00000503206
ENST00000508633 ENST00000506730 ENST00000382968(uc003gci.3 uc003gcj.3 uc010ibp.3 uc010ibq.3)
ENST00000433731 ENST00000511620 ENST00000508428 ENST00000510715 ENST00000512552
ENST00000333673(uc021xkh.1) ENST00000454487 ENST00000505730
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF212 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF212 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): RNF212 (NM_194439) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RNF212 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF212 |
Additional cDNA sequence: AK096160.1 BC036250.1 BC050356.1 BC101258.1 BC101259.1 BC101260.1 XR_171443.1 9 DOTS entries: DT.91800822 DT.75148311 DT.101957909 DT.95108098 DT.121263249 DT.121263237 DT.99992920 DT.100009409 DT.95281596 24/33 AceView cDNA sequences (see all 33): AK096160 CR620687 AI859750 NM_194439 AW195334 CK822262 BG701603 BC050356 BQ931991 AL535800 BQ185774 AI203909 BM312986 AK124578 BF510048 AW105133 BI460105 AA812722 AA740318 AA902488 BG196869 BC036250 BX409734 AA813338
GeneLoc Exon Structure
|
Expression
for RNF212 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RNF212 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTTCAGCTC
About this image
See RNF212 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RNF212
SOURCE GeneReport for Unigene cluster: Hs.248290
SABiosciences Expression via Pathway-Focused PCR Array including RNF212: | Ubiquitin Ligases in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNF212
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat RNF212 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNF212 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNF212 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF212 |
Orthologs
for RNF212 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for RNF212 gene from 4/9 species (see all 9) About this table
ENSEMBL Gene Tree for RNF212 (if available)
TreeFam Gene Tree for RNF212 (if available) |
Paralogs
for RNF212 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RNF212 gene
- C14orf1642
RNF212 for paralogs About GeneDecksing
|
Genomic Variants
for RNF212 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
UniProtKB/Swiss-Prot: RN212_HUMAN, Q495C1Polymorphism: Genetic variations in RNF212 influence recombination rate, designated recombination rate quantitativetrait locus 1 (RRQTL1) [MIM:612042] (PubMed:18239089)
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 4 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RNF212 (1050038 - 1107582 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 16 variations for RNF212
10 CNVs: 80141 91874 80139 68600 91873 91876 30190 91875 80140 68599
6 Indels: 80143 91877 12378 27412 80142 27413 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNF212 |
|
Disorders
/ Diseases
for RNF212 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RNF212 for disorders About GeneDecksing
OMIM gene information: 612041
OMIM disorders: 612042
1  disease for RNF212: About MalaCardsrecombination rate qtl 1
Human Genome Epidemiology (HuGE) Navigator: RNF212 (1 document)
Export disorders for RNF212 gene to outside databases
|
Publications
for RNF212 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RNF212 gene integrated from 9 sources:
(articles sorted by number of sources associating them with RNF212) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Sequence variants in the RNF212 gene associate with genome-wide recombination rate. (PubMed id 18239089)1, 2 Kong A.... Stefansson K. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Genetic analysis of variation in human meiotic recomb ination. (PubMed id 19763160)1 Chowdhury R....Cheung V.G. (2009)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
- Targeted gene knockout reveals a role in meiotic reco mbination for ZHP-3, a Zip3-related protein in Caenorhabditis elegans. (PubMed id 15340062)1 Jantsch V....Loidl J. (2004)
|
External Searches for RNF212 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RNF212 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RNF212 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RNF212 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RNF212 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RNF212 gene:
Search GeneIP for patents involving RNF212
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RNF212 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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 | | | RNF212 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF212 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF212 |
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