Aliases for RNF212 Gene
External Ids for RNF212 Gene
Previous HGNC Symbols for RNF212 Gene
This gene encodes a RING finger protein that may function as a ubiquitin ligase. The encoded protein may be involved in meiotic recombination. This gene is located within a linkage disequilibrium block and polymorphisms in this gene may influence recombination rates. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2010]
GeneCards Summary for RNF212 Gene
RNF212 (Ring Finger Protein 212) is a Protein Coding gene. Diseases associated with RNF212 include Recombination Rate Qtl 1. GO annotations related to this gene include ligase activity. An important paralog of this gene is RNF212B.
UniProtKB/Swiss-Prot for RNF212 Gene
SUMO E3 ligase that acts as a regulator of crossing-over during meiosis: required to couple chromosome synapsis to the formation of crossover-specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May mediate sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement and plays an antagonist role with CCNB1IP1/HEI10 in the regulation of meiotic recombination (By similarity).