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RNF212 Gene

protein-coding   GIFtS: 45
GCID: GC04M001057

Ring Finger Protein 212

(Previous name: hypothetical protein LOC285498)
(Previous symbol: LOC285498)
  See RNF212-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ring Finger Protein 2121 2 3
ZHP32 5
LOC2854981
Hypothetical Protein LOC2854981
Probable E3 SUMO-Protein Ligase RNF2122
EC 6.3.2.-3

External Ids:    HGNC: 277291   Entrez Gene: 2854982   Ensembl: ENSG000001782227   OMIM: 6120415   UniProtKB: Q495C13   

Export aliases for RNF212 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RNF212 Gene:
This gene encodes a RING finger protein that may function as a ubiquitin ligase. The encoded protein may be
involved in meiotic recombination. This gene is located within a linkage disequilibrium block and polymorphisms
in this gene may influence recombination rates. Alternate splicing results in multiple transcript
variants.(provided by RefSeq, Oct 2010)

GeneCards Summary for RNF212 Gene:
RNF212 (ring finger protein 212) is a protein-coding gene. Diseases associated with RNF212 include recombination rate qtl 1. GO annotations related to this gene include ligase activity. An important paralog of this gene is C14orf164.

UniProtKB/Swiss-Prot: RN212_HUMAN, Q495C1
Function: SUMO E3 ligase that acts as a regulator of crossing-over during meiosis: required to couple chromosome
synapsis to the formation of crossover-specific recombination complexes. Localizes to recombination sites and
stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11.
May mediate sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination
sites. Acts as a limiting factor for crossover designation and/or reinforcement and plays an antagonist role with
CCNB1IP1/HEI10 in the regulation of meiotic recombination (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_006051.19  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RNF212 gene promoter:
         SRF   Tal-1   AP-1   SRF (504 AA)   E4BP4   E47   c-Ets-1   FOXO1a   ZID   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNF212 promoter sequence
   Search Chromatin IP Primers for RNF212

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNF212


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.3   Ensembl cytogenetic band:  4p16.3   HGNC cytogenetic band: 4p16.3

RNF212 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF212 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M001057:  view genomic region     (about GC identifiers)

Start:
1,050,038 bp from pter      End:
1,107,352 bp from pter
Size:
57,315 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RN212_HUMAN, Q495C1 (See protein sequence)
Recommended Name: Probable E3 SUMO-protein ligase RNF212  
Size: 297 amino acids; 33365 Da
Secondary accessions: C9J8N0 Q495C0 Q86W82 Q8IY99 Q8N8U7
Alternative splicing: 6 isoforms:  Q495C1-1   Q495C1-2   Q495C1-3   Q495C1-4   Q495C1-5   Q495C1-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RNF212: NX_Q495C1

Explore proteomics data for RNF212 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RNF212 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001124506.1  NP_001180247.1  NP_919420.1  

    ENSEMBL proteins: 
     ENSP00000425843   ENSP00000372428   ENSP00000389709   ENSP00000426115   ENSP00000423030  
     ENSP00000423560   ENSP00000327481  

    RNF212 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for RNF212

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers

    2 InterPro protein domains:
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING

    Graphical View of Domain Structure for InterPro Entry Q495C1

    ProtoNet protein and cluster: Q495C1

    UniProtKB/Swiss-Prot: RN212_HUMAN, Q495C1
    Similarity: Contains 1 RING-type zinc finger


    Find genes that share domains with RNF212           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RN212_HUMAN, Q495C1
    Function: SUMO E3 ligase that acts as a regulator of crossing-over during meiosis: required to couple chromosome
    synapsis to the formation of crossover-specific recombination complexes. Localizes to recombination sites and
    stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11.
    May mediate sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination
    sites. Acts as a limiting factor for crossover designation and/or reinforcement and plays an antagonist role with
    CCNB1IP1/HEI10 in the regulation of meiotic recombination (By similarity)

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0016874ligase activity IEA--
         
    Find genes that share ontologies with RNF212           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Rnf212):
     reproductive system 

    Find genes that share phenotypes with RNF212           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Rnf212tm1Nhtr for RNF212

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RNF212
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RN212_HUMAN, Q495C1: Nucleus (By similarity). Chromosome (By similarity). Note=Associates to the synaptonemal
    complex. Localizes to a minority of double-strand breaks (DSBs) sites. Marks crossover sites during midpachynema
    (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000795colocalizes with synaptonemal complex ISS--

    Find genes that share ontologies with RNF212           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    UniProtKB/Swiss-Prot: RN212_HUMAN, Q495C1
    Pathway: Protein modification; protein sumoylation

        Pathway & Disease-focused RT2 Profiler PCR Array including RNF212: 

              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for RNF212

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    Selected Interacting proteins for RNF212 (ENSP000003897094) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    C14orf164ENSP000003978304STRING: ENSP00000397830
    SPO11ENSP000003603104STRING: ENSP00000360310
    UBE2IENSP000003248974STRING: ENSP00000324897
    MRE11AENSP000003258634STRING: ENSP00000325863
    MSH4ENSP000002631874STRING: ENSP00000263187
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    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006311meiotic gene conversion ISS--
    GO:0007131reciprocal meiotic recombination ISS--
    GO:0016925protein sumoylation IEA--
    GO:0051026chiasma assembly ISS--

    Find genes that share ontologies with RNF212           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RNF212 (RN212)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RNF212 gene (3 alternative transcripts): 
    NM_001131034.3  NM_001193318.2  NM_194439.4  

    Unigene Cluster for RNF212:

    Ring finger protein 212
    Hs.248290  [show with all ESTs]
    Unigene Representative Sequence: XR_171443
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000514024(uc021xkg.1) ENST00000503206 ENST00000514757 ENST00000505693
    ENST00000508633 ENST00000506730 ENST00000382968(uc003gci.3 uc003gcj.3 uc010ibp.3 uc010ibq.3)
    ENST00000433731 ENST00000511620 ENST00000508428 ENST00000510715 ENST00000512552
    ENST00000333673(uc021xkh.1) ENST00000454487 ENST00000505730
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat RNF212

    Additional mRNA sequence: 

    AK096160.1 BC036250.1 BC050356.1 BC101258.1 BC101259.1 BC101260.1 XR_171443.1 

    9 DOTS entries:

    DT.91800822  DT.75148311  DT.101957909  DT.95108098  DT.121263249  DT.121263237  DT.99992920  DT.100009409 
    DT.95281596 

    Selected AceView cDNA sequences (see all 33):

    AK096160 CR620687 AI859750 NM_194439 AW195334 BQ185774 BC050356 AI203909 
    BQ931991 AL535800 AK124578 AW105133 CK822262 BM312986 BF510048 BG701603 
    AA902488 AA740318 BI460105 AA812722 BC036250 BU728567 BG196869 AA813338 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RNF212 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTCAGCTC
    RNF212 Expression
    About this image

    RNF212 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RNF212 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.248290
        Pathway & Disease-focused RT2 Profiler PCR Array including RNF212: 
              Ubiquitin Ligases in human mouse rat

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    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RNF212 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnf2121 , 5 ring finger protein 2121, 5 82.2(n)1
    76.44(a)1
      5 (53.24 cM)5
    6715641  XM_006535331.11  XP_006535394.11 
     1087316615 
    chicken
    (Gallus gallus)
    Aves RNF2121 ring finger protein 212 64.97(n)
    56.85(a)
      100859859  XM_004936236.1  XP_004936293.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia rnf2121 ring finger protein 212 54.9(n)
    44.92(a)
      101733053  XM_004911478.1  XP_004911535.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005347931 probable E3 SUMO-protein ligase RNF212-like 48.66(n)
    36.5(a)
      100534793  XM_003199860.2  XP_003199908.2 
    worm
    (Caenorhabditis elegans)
    Secernentea D1081.96
    zhp-36
    Protein D1081.9 (D1081.9) mRNA, complete cds
    Protein ZHP-3, isoform a (zhp-3) mRNA, complete cd...
    16(a)
    11(a)
    many ↔ many
    many ↔ many
    I(8485810-8487043) WBGene00008387
    I(8529381-8531338) WBGene00006976


    ENSEMBL Gene Tree for RNF212 (if available)
    TreeFam Gene Tree for RNF212 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RNF212 gene
    C14orf1642  

    Find genes that share paralogs with RNF212           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    RN212_HUMAN, Q495C1: Genetic variations in RNF212 influence recombination rate, designated recombination rate
    quantitative trait locus 1 (RRQTL1) [MIM:612042] (PubMed:18239089)


    Selected SNPs for RNF212 (see all 1155)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1422286671,2
    Cuntested11066770(+) AAGACA/GGCCCT 3 A syn1 ut310--------
    rs1915372901,2
    --1064832(+) TTTTTC/TAAATA 2 -- ds50010--------
    rs68272061,2
    C,F,A,H--1065071(+) TTTTTT/AAAATA 2 -- ds500112Minor allele frequency- A:0.20NS EA NA WA 788
    rs1816306631,2
    --1065076(+) AAAATA/GCTATT 2 -- ds50010--------
    rs1867613301,2
    C--1065088(+) TTACAA/G/TTTTTT 2 -- ds50010--------
    rs126452891,2
    C,H--1065210(+) gaattC/Ttgttc 2 -- ds50016Minor allele frequency- T:0.00NS EA NA 412
    rs1913065531,2
    --1065292(+) TATCTC/GATAAG 2 -- ut310--------
    rs784981931,2
    C--1065413(+) TACCTA/TAACAG 2 -- ut310--------
    rs1459907061,2
    C--1065480(+) TATGTC/TATCAA 2 -- ut310--------
    rs799988571,2
    C--1065486(+) ATCAAT/CGAAAT 2 -- ut312Minor allele frequency- C:0.10CSA WA 119

    HapMap Linkage Disequilibrium report for RNF212 (1050038 - 1107352 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for RNF212 (see all 18):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2726753CNV Deletion23290073
    esv1191684CNV Deletion17803354
    esv2726752CNV Deletion23290073
    dgv848e201CNV Deletion23290073
    esv2726750CNV Deletion23290073
    esv1505561CNV Deletion17803354
    dgv849e201CNV Deletion23290073
    esv996519CNV Deletion20482838
    esv1703084CNV Deletion17803354
    nsv292333CNV Loss16902084

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RNF212
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612041   
    OMIM disorders: 612042  
    1 disease for RNF212:    
    About MalaCards
    recombination rate qtl 1


    Find genes that share disorders with RNF212           About GenesLikeMe

    Genetic Association Database (GAD): RNF212
    Human Genome Epidemiology (HuGE) Navigator: RNF212 (1 document)

    Export disorders for RNF212 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RNF212 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with RNF212)
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    1. Sequence variants in the RNF212 gene associate with genome-wide recombination rate. (PubMed id 18239089)1, 2, 4 Kong A.... Stefansson K. (Science 2008)
    2. RNF212 is a dosage-sensitive regulator of crossing-over during mammalian meiosis. (PubMed id 23396135)1, 3 Reynolds A....Hunter N. (Nat. Genet. 2013)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    6. Genetic analysis of variation in human meiotic recombination. (PubMed id 19763160)1 Chowdhury R....Cheung V.G. (PLoS Genet. 2009)
    7. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    9. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W.... Wilson R.K. (Nature 2005)
    10. Targeted gene knockout reveals a role in meiotic recombination for ZHP-3, a Zip3-related protein in Caenorhabditis elegans. (PubMed id 15340062)1 Jantsch V....Loidl J. (Mol. Cell. Biol. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 285498 HGNC: 27729 AceView: LOC285498 Ensembl:ENSG00000178222 euGenes: HUgn285498
    ECgene: RNF212 H-InvDB: RNF212

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RNF212 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RNF212 gene:
    Search GeneIP for patents involving RNF212

    GeneCards and IP:
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