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Aliases for RNF208 Gene

Aliases for RNF208 Gene

  • Ring Finger Protein 208 2 3 5

External Ids for RNF208 Gene

Previous GeneCards Identifiers for RNF208 Gene

  • GC09P9S0001
  • GC09M139237
  • GC09M140114
  • GC09M109574

Summaries for RNF208 Gene

GeneCards Summary for RNF208 Gene

RNF208 (Ring Finger Protein 208) is a Protein Coding gene. GO annotations related to this gene include ubiquitin-protein transferase activity.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF208 Gene

Genomics for RNF208 Gene

Regulatory Elements for RNF208 Gene

Enhancers for RNF208 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G137221 2.1 FANTOM5 Ensembl ENCODE dbSUPER 7.2 -5.5 -5515 11.2 HDGF PKNOX1 CREB3L1 AGO1 ZFP64 ARID4B SIN3A FEZF1 ZNF2 ZBTB7B RNF208 CYSRT1 NDOR1 RNF224 SLC34A3 MRPL41 GRIN1 FBXW5 NSMF NPDC1
GH09G137216 1.6 Ensembl ENCODE dbSUPER 7.5 +3.3 3302 3.7 HDGF PKNOX1 FOXA2 ARNT AGO1 ARID4B SIN3A DMAP1 SLC30A9 FOS NDOR1 RNF208 CYSRT1 NPDC1
GH09G137204 1.1 ENCODE 4.8 +15.9 15869 3.3 CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 KLF13 CYSRT1 SLC34A3 NDOR1 RNF208
GH09G137516 0.7 FANTOM5 4.8 -295.6 -295575 0.4 BCL11B ZKSCAN1 MTA3 CTBP1 ZNF366 ZNF169 ZBTB2 MTA2 ZNF592 ZSCAN21 GRIN1 RNF208 SAPCD2 ABCA2 PNPLA7 CACNA1B ENTPD2 PIR51097 PIR44519
GH09G137233 1.8 FANTOM5 ENCODE dbSUPER 1.8 -16.7 -16725 9.9 MLX CREB3L1 AGO1 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF263 SP3 NDOR1 DPH7 TMEM203 NELFB LCN15 ABCA2 TOR4A UAP1L1 RNF224 CYSRT1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RNF208 on UCSC Golden Path with GeneCards custom track

Promoters for RNF208 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000243163 -619 1201 HDGF ARID4B THRB ZNF48 RARA GLIS2 SP5 NR2F2 ZFP69B ZNF341

Genomic Location for RNF208 Gene

Chromosome:
9
Start:
137,220,247 bp from pter
End:
137,221,581 bp from pter
Size:
1,335 bases
Orientation:
Minus strand

Genomic View for RNF208 Gene

Genes around RNF208 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF208 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF208 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF208 Gene

Proteins for RNF208 Gene

  • Protein details for RNF208 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0X6-RN208_HUMAN
    Recommended name:
    RING finger protein 208
    Protein Accession:
    Q9H0X6
    Secondary Accessions:
    • A2BFA0

    Protein attributes for RNF208 Gene

    Size:
    261 amino acids
    Molecular mass:
    27964 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH16958.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH16958.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=AAL16809.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB66475.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for RNF208 Gene

Post-translational modifications for RNF208 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RNF208 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RNF208 Gene

Domains & Families for RNF208 Gene

Gene Families for RNF208 Gene

Protein Domains for RNF208 Gene

Suggested Antigen Peptide Sequences for RNF208 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RNF208: view

No data available for UniProtKB/Swiss-Prot for RNF208 Gene

Function for RNF208 Gene

Gene Ontology (GO) - Molecular Function for RNF208 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 24105792
GO:0005515 protein binding IPI 16189514
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RNF208: view

Phenotypes for RNF208 Gene

genes like me logo Genes that share phenotypes with RNF208: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RNF208 Gene

Localization for RNF208 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNF208 gene
Compartment Confidence
nucleus 5
cytosol 5
peroxisome 1

Gene Ontology (GO) - Cellular Components for RNF208 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with RNF208: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RNF208 Gene

Pathways & Interactions for RNF208 Gene

SuperPathways for RNF208 Gene

No Data Available

Interacting Proteins for RNF208 Gene

Gene Ontology (GO) - Biological Process for RNF208 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051865 protein autoubiquitination IDA 24105792
genes like me logo Genes that share ontologies with RNF208: view

No data available for Pathways by source and SIGNOR curated interactions for RNF208 Gene

Drugs & Compounds for RNF208 Gene

No Compound Related Data Available

Transcripts for RNF208 Gene

mRNA/cDNA for RNF208 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RNF208 Gene

Ring finger protein 208:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF208 Gene

No ASD Table

Relevant External Links for RNF208 Gene

GeneLoc Exon Structure for
RNF208
ECgene alternative splicing isoforms for
RNF208

Expression for RNF208 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNF208 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNF208 Gene

This gene is overexpressed in Brain - Cortex (x5.3) and Brain - Frontal Cortex (BA9) (x4.2).

NURSA nuclear receptor signaling pathways regulating expression of RNF208 Gene:

RNF208

SOURCE GeneReport for Unigene cluster for RNF208 Gene:

Hs.512767

Evidence on tissue expression from TISSUES for RNF208 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with RNF208: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNF208 Gene

Orthologs for RNF208 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNF208 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNF208 34
  • 99.27 (n)
oppossum
(Monodelphis domestica)
Mammalia RNF208 35
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RNF208 34 35
  • 88.89 (n)
dog
(Canis familiaris)
Mammalia RNF208 34 35
  • 88.51 (n)
mouse
(Mus musculus)
Mammalia Rnf208 34 16 35
  • 87.61 (n)
rat
(Rattus norvegicus)
Mammalia Rnf208 34
  • 87.36 (n)
chicken
(Gallus gallus)
Aves RNF208 34 35
  • 73.69 (n)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-106l3.6 34
  • 62.25 (n)
RNF208 35
  • 58 (a)
OneToOne
Species where no ortholog for RNF208 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF208 Gene

ENSEMBL:
Gene Tree for RNF208 (if available)
TreeFam:
Gene Tree for RNF208 (if available)

Paralogs for RNF208 Gene

No data available for Paralogs for RNF208 Gene

Variants for RNF208 Gene

Sequence variations from dbSNP and Humsavar for RNF208 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1001341160 -- 137,220,823(+) GCCGC(C/G/T)GAGGC reference, synonymous-codon
rs1001551269 -- 137,220,033(+) CTGTA(C/T)GTGTG downstream-variant-500B
rs1002346914 -- 137,222,719(+) GCGGA(A/G)CGGAT upstream-variant-2KB
rs1002441843 -- 137,222,922(+) TCTGC(C/T)TGTGG upstream-variant-2KB
rs1004228476 -- 137,222,189(+) CGCGG(A/G)TTTCG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RNF208 Gene

Variant ID Type Subtype PubMed ID
dgv13009n54 CNV loss 21841781
dgv13010n54 CNV loss 21841781
esv2422220 CNV deletion 17116639
nsv1126931 CNV deletion 24896259
nsv1161918 CNV duplication 26073780
nsv524322 CNV loss 19592680
nsv616007 CNV loss 21841781
nsv616012 CNV loss 21841781
nsv951207 CNV deletion 24416366

Variation tolerance for RNF208 Gene

Residual Variation Intolerance Score: 68% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.69; 14.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNF208 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNF208

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF208 Gene

Disorders for RNF208 Gene

Relevant External Links for RNF208

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RNF208

No disorders were found for RNF208 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF208 Gene

Publications for RNF208 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 64
  2. Protein microarray characterization of the S-nitrosoproteome. (PMID: 24105792) Lee Y.I. … Dawson T.M. (Mol. Cell Proteomics 2014) 3 64
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  4. Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks. (PMID: 22493164) Woodsmith J. … Sanderson C.M. (Mol. Cell Proteomics 2012) 3 64
  5. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PMID: 19690332) Mayya V. … Han D.K. (Sci. Signal. 2009) 4 64

Products for RNF208 Gene

Sources for RNF208 Gene

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