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Aliases for RNF208 Gene

Aliases for RNF208 Gene

  • Ring Finger Protein 208 2 3 5

External Ids for RNF208 Gene

Previous GeneCards Identifiers for RNF208 Gene

  • GC09P9S0001
  • GC09M139237
  • GC09M140114
  • GC09M109574

Summaries for RNF208 Gene

GeneCards Summary for RNF208 Gene

RNF208 (Ring Finger Protein 208) is a Protein Coding gene. GO annotations related to this gene include ubiquitin-protein transferase activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF208 Gene

Genomics for RNF208 Gene

Regulatory Elements for RNF208 Gene

Enhancers for RNF208 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RNF208 on UCSC Golden Path with GeneCards custom track

Promoters for RNF208 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RNF208 on UCSC Golden Path with GeneCards custom track

Genomic Location for RNF208 Gene

137,220,247 bp from pter
137,221,581 bp from pter
1,335 bases
Minus strand

Genomic View for RNF208 Gene

Genes around RNF208 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF208 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF208 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF208 Gene

Proteins for RNF208 Gene

  • Protein details for RNF208 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RING finger protein 208
    Protein Accession:
    Secondary Accessions:
    • A2BFA0

    Protein attributes for RNF208 Gene

    261 amino acids
    Molecular mass:
    27964 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH16958.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH16958.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=AAL16809.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB66475.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for RNF208 Gene

Proteomics data for RNF208 Gene at MOPED

Post-translational modifications for RNF208 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RNF208 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RNF208 Gene

Domains & Families for RNF208 Gene

Gene Families for RNF208 Gene

Protein Domains for RNF208 Gene

Suggested Antigen Peptide Sequences for RNF208 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 RING-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF208: view

Function for RNF208 Gene

Gene Ontology (GO) - Molecular Function for RNF208 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 24105792
GO:0005515 protein binding IEA,IPI 16189514
genes like me logo Genes that share ontologies with RNF208: view

Phenotypes for RNF208 Gene

GenomeRNAi human phenotypes for RNF208:
genes like me logo Genes that share phenotypes with RNF208: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RNF208 Gene

Localization for RNF208 Gene

Subcellular locations from

Jensen Localization Image for RNF208 Gene COMPARTMENTS Subcellular localization image for RNF208 gene
Compartment Confidence
nucleus 5
cytosol 3
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RNF208 Gene

Pathways & Interactions for RNF208 Gene

SuperPathways for RNF208 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RNF208 Gene


No data available for Pathways by source and SIGNOR curated interactions for RNF208 Gene

Drugs & Compounds for RNF208 Gene

No Compound Related Data Available

Transcripts for RNF208 Gene

mRNA/cDNA for RNF208 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RNF208 Gene

Ring finger protein 208:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNF208 Gene

No ASD Table

Relevant External Links for RNF208 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNF208 Gene

mRNA expression in normal human tissues for RNF208 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNF208 Gene

This gene is overexpressed in Brain - Cortex (x5.3) and Brain - Frontal Cortex (BA9) (x4.2).

SOURCE GeneReport for Unigene cluster for RNF208 Gene Hs.512767

genes like me logo Genes that share expression patterns with RNF208: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for RNF208 Gene

Orthologs for RNF208 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNF208 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RNF208 35
  • 88.89 (n)
  • 90.8 (a)
RNF208 36
  • 90 (a)
(Canis familiaris)
Mammalia RNF208 35
  • 88.51 (n)
  • 93.1 (a)
RNF208 36
  • 63 (a)
(Mus musculus)
Mammalia Rnf208 35
  • 87.61 (n)
  • 94.25 (a)
Rnf208 16
Rnf208 36
  • 94 (a)
(Pan troglodytes)
Mammalia RNF208 35
  • 99.27 (n)
  • 100 (a)
(Rattus norvegicus)
Mammalia Rnf208 35
  • 87.36 (n)
  • 94.25 (a)
(Monodelphis domestica)
Mammalia RNF208 36
  • 91 (a)
(Gallus gallus)
Aves RNF208 35
  • 73.69 (n)
  • 72.73 (a)
RNF208 36
  • 67 (a)
(Danio rerio)
Actinopterygii si:dkey-106l3.6 35
  • 62.25 (n)
  • 60.26 (a)
RNF208 36
  • 58 (a)
Species with no ortholog for RNF208:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF208 Gene

Gene Tree for RNF208 (if available)
Gene Tree for RNF208 (if available)

Paralogs for RNF208 Gene

No data available for Paralogs for RNF208 Gene

Variants for RNF208 Gene

Sequence variations from dbSNP and Humsavar for RNF208 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs114411688 -- 137,222,512(+) CACAG(C/T)AGGAG upstream-variant-2KB
rs191950892 -- 137,220,350(+) TCAGC(A/G)GGCGG utr-variant-3-prime
rs117537816 -- 137,221,888(+) TCCCC(A/G)GTCCC upstream-variant-2KB
rs138418399 -- 137,221,287(+) CAGGG(C/T)AGCAT utr-variant-5-prime
rs138917279 -- 137,220,530(+) CAGCC(C/G)CCCAC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for RNF208 Gene

Variant ID Type Subtype PubMed ID
nsv894387 CNV Gain 21882294
esv2422220 CNV Deletion 17116639
dgv8412n71 CNV Loss 21882294
dgv8416n71 CNV Loss 21882294
nsv524322 CNV Loss 19592680
nsv894469 CNV Loss 21882294
dgv8423n71 CNV Loss 21882294
nsv894502 CNV Loss 21882294
nsv894506 CNV Gain 21882294
dgv8428n71 CNV Loss 21882294
nsv894521 CNV Loss 21882294
dgv8437n71 CNV Gain 21882294
dgv8441n71 CNV Loss 21882294
dgv8442n71 CNV Loss 21882294
dgv8445n71 CNV Loss 21882294
dgv8446n71 CNV Loss 21882294
dgv8447n71 CNV Loss 21882294
dgv8450n71 CNV Loss 21882294
nsv894603 CNV Gain+Loss 21882294
dgv8451n71 CNV Loss 21882294
dgv8452n71 CNV Gain+Loss 21882294
dgv8453n71 CNV Gain 21882294
dgv8454n71 CNV Gain 21882294
dgv8455n71 CNV Gain+Loss 21882294
dgv8456n71 CNV Loss 21882294
nsv894631 CNV Loss 21882294
dgv8457n71 CNV Gain 21882294
nsv894637 CNV Loss 21882294
nsv894639 CNV Loss 21882294
nsv894640 CNV Loss 21882294

Variation tolerance for RNF208 Gene

Residual Variation Intolerance Score: 68% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.69; 14.69% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RNF208 Gene

Disorders for RNF208 Gene

Relevant External Links for RNF208

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RNF208 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF208 Gene

Publications for RNF208 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 67
  2. Protein microarray characterization of the S-nitrosoproteome. (PMID: 24105792) Lee Y.I. … Dawson T.M. (Mol. Cell Proteomics 2014) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks. (PMID: 22493164) Woodsmith J. … Sanderson C.M. (Mol. Cell Proteomics 2012) 3
  5. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3

Products for RNF208 Gene

Sources for RNF208 Gene