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RNF207 Gene

protein-coding   GIFtS: 41
GCID: GC01P006265

Ring Finger Protein 207

(Previous name: chromosome 1 open reading frame 188)
(Previous symbol: C1orf188)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ring Finger Protein 2071 2
C1orf1881 2 3
OTTHUMG000000010891
Chromosome 1 Open Reading Frame 1881

External Ids:    HGNC: 329471   Entrez Gene: 3885912   Ensembl: ENSG000001582867   UniProtKB: Q6ZRF83   

Export aliases for RNF207 gene to outside databases

Previous GC identifers: GC01P006188 GC01P005414


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RNF207 Gene:
RNF207 (ring finger protein 207) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the RNF207 gene promoter:
         ER-alpha   GR   p53   GR-beta   Egr-1   Pax-2   MIF-1   Pax-2a   Egr-4   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNF207 promoter sequence
   Search Chromatin IP Primers for RNF207

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNF207


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.31   Ensembl cytogenetic band:  1p36.31   HGNC cytogenetic band: 1p36.31

RNF207 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF207 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P006265:  view genomic region     (about GC identifiers)

Start:
6,265,535 bp from pter      End:
6,281,359 bp from pter
Size:
15,825 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RN207_HUMAN, Q6ZRF8 (See protein sequence)
Recommended Name: RING finger protein 207  
Size: 634 amino acids; 70861 Da
Sequence caution: Sequence=AAI28238.1; Type=Erroneous initiation;
Secondary accessions: A2VCM8 B4DFR6 Q5TGS6 Q6ZS63 Q96MP2
Alternative splicing: 4 isoforms:  Q6ZRF8-1   Q6ZRF8-2   Q6ZRF8-3   Q6ZRF8-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RNF207: NX_Q6ZRF8

Explore proteomics data for RNF207 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RNF207 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_997279.2  
    ENSEMBL proteins: 
     ENSP00000367173   ENSP00000367183  

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    antibodies-online peptides for RNF207

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    antibodies-online antibodies for RNF207 (12 products) 

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    antibodies-online kits for RNF207 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers

    5 InterPro protein domains:
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR000315 Znf_B-box
     IPR018957 Znf_C3HC4_RING-type
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q6ZRF8

    ProtoNet protein and cluster: Q6ZRF8

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: RN207_HUMAN, Q6ZRF8
    Similarity: Contains 1 B box-type zinc finger
    Similarity: Contains 1 RING-type zinc finger


    Find genes that share domains with RNF207           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with RNF207           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for RNF207:
     Decreased viability of wild-ty  Increased HPV18 LCR reporter a  Increased gamma-H2AX phosphory 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for RNF207

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate RNF207 (see all 11):
    hsa-miR-1290 hsa-miR-513a-5p hsa-miR-27a hsa-miR-876-5p hsa-miR-548e hsa-miR-219-5p hsa-miR-3167 hsa-miR-508-3p
    SwitchGear 3'UTR luciferase reporter plasmidRNF207 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF207


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    golgi apparatus1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IEA--

    Find genes that share ontologies with RNF207           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including RNF207: 
              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for RNF207

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RNF207 (RN207)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RNF207 gene (2 alternative transcripts): 
    NM_173795.2  NM_207396.2  

    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000466994(uc001amf.1) ENST00000484435 ENST00000377939(uc001amg.3)
    ENST00000485539(uc001amh.3) ENST00000496676(uc010nzp.1) ENST00000463453
    ENST00000496329 ENST00000492476 ENST00000483336 ENST00000377948
    miRNA
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    hsa-miR-1290 hsa-miR-513a-5p hsa-miR-27a hsa-miR-876-5p hsa-miR-548e hsa-miR-219-5p hsa-miR-3167 hsa-miR-508-3p
    SwitchGear 3'UTR luciferase reporter plasmidRNF207 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: RNF207 (NM_207396)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNF207
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat RNF207
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RNF207
      QuantiTect SYBR Green Assays in human, mouse, rat RNF207
      QuantiFast Probe-based Assays in human, mouse, rat RNF207

    10 AceView cDNA sequences:

    BM669545 CD673733 AI474487 AI620515 BF510516 NM_207396 AK128246 BM698769 
    BM310807 BM310499 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for RNF207    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14
    SP1:              -     -                                                                                       
    SP2:                                                                                                            
    SP3:                                                                                -           -               
    SP4:                                                                                -                           
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for RNF207

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RNF207 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAGGATGAG
    RNF207 Expression
    About this image


    RNF207 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Neurons
             Mature Rod Cells Outer Nuclear Layer
     
     Eye (Sensory Organs)
             Mature Rod Cells Outer Nuclear Layer
     
     Heart (Cardiovascular System)
    RNF207 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RNF207 Protein Expression
        Pathway & Disease-focused RT2 Profiler PCR Array including RNF207: 
              Ubiquitin Ligases in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF207

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RNF207 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnf2071 , 5 ring finger protein 2071, 5 83.36(n)1
    82.83(a)1
      4 (83.02 cM)5
    4338091  NM_001033489.21  NP_001028661.21 
     1523070195 
    chicken
    (Gallus gallus)
    Aves RNF2071 ring finger protein 207 72.04(n)
    64.75(a)
      419374  XM_004947344.1  XP_004947401.1 
    lizard
    (Anolis carolinensis)
    Reptilia RNF2076
    ring finger protein 207
    64(a)
    1 ↔ 1
    AAWZ02035903(23888-35075)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia rnf2071 ring finger protein 207 64.83(n)
    65.21(a)
      100487154  XM_002937546.2  XP_002937592.2 
    zebrafish
    (Danio rerio)
    Actinopterygii rnf207b1 ring finger protein 207b 64.47(n)
    62.06(a)
      568322  NM_001201449.1  NP_001188378.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F47G9.41 F47G9.4 41.23(n)
    30.16(a)
      179566  NM_073475.3  NP_505876.2 


    ENSEMBL Gene Tree for RNF207 (if available)
    TreeFam Gene Tree for RNF207 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    RN207_HUMAN, Q6ZRF8: Genetic variation in RNF207 may influence the duration of QT interval, a mesure of cardiac
    repolarization that depends on multiple environmental and genetic contributors. Prolonged or shortened QT
    intervals predisposes to ventricular arrhythmias and are a risk factor for sudden cardiac death


    Selected SNPs for RNF207 (see all 413)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1909533401,2
    --6264243(+) CCCAGA/GAGGCG 1 -- us2k10--------
    rs342760481,2
    C--6264315(+) AAAAA-/AGAACC 1 -- us2k10--------
    rs2020079961,2
    C--6264330(-) TGGTTC/TTNNNN 1 -- us2k10--------
    rs1831421051,2
    --6264388(+) CACTTC/TCTTCT 1 -- us2k10--------
    rs563948361,2
    C--6264410(+) CCTACC/TCCTAC 1 -- us2k10--------
    rs1163092551,2
    F--6264451(+) CAAGGC/TGGCTC 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1876867691,2
    --6264544(+) CAGCAA/GAACCC 1 -- us2k10--------
    rs356231361,2
    C--6264597(+) AATAC-/A/AAA 
            
    AAAAA
    2 -- us2k1 cds12NA 4
    rs1133875861,2
    C--6264666(+) GGCCAA/GGGTGG 1 -- us2k10--------
    rs43149001,2
    C--6264757(+) TAGCCA/GGGCAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RNF207 (6265535 - 6281359 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for RNF207:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508825CNV Insertion20534489
    nsv871698CNV Loss21882294
    dgv121n71CNV Loss21882294
    dgv120n71CNV Loss21882294
    nsv870945CNV Loss21882294
    nsv831425CNV Loss17160897
    dgv119n71CNV Loss21882294
    dgv8n67CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RNF207
    DNA2.0 Custom Variant and Variant Library Synthesis for RNF207

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with RNF207           About GenesLikeMe

    Genetic Association Database (GAD): RNF207
    Human Genome Epidemiology (HuGE) Navigator: RNF207 (2 documents)

    Export disorders for RNF207 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RNF207 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with RNF207)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Common variants at ten loci modulate the QT interval duration in the QTSCD Study. (PubMed id 19305409)1, 2, 4 Pfeufer A.... Chakravarti A. (Nat. Genet. 2009)
    2. Common variants at ten loci influence QT interval duration in the QTGEN Study. (PubMed id 19305408)1, 2, 4 Newton-Cheh C.... Stricker B.H. (Nat. Genet. 2009)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (Nature 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Expressed sequence tag analysis of adult human lens for the NEIBank project: over 2000 non-redundant transcripts, novel genes and splice variants. (PubMed id 12107413)1 Wistow G.... Peterson K. (Mol. Vis. 2002)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    9. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 388591 HGNC: 32947 AceView: FLJ46380 Ensembl:ENSG00000158286 euGenes: HUgn388591
    ECgene: RNF207 H-InvDB: RNF207

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RNF207 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RNF207 gene:
    Search GeneIP for patents involving RNF207

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