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Aliases for RNF207 Gene

Aliases for RNF207 Gene

  • Ring Finger Protein 207 2 3 5
  • C1orf188 3 4
  • Chromosome 1 Open Reading Frame 188 2
  • OTTHUMG00000001089 2

External Ids for RNF207 Gene

Previous HGNC Symbols for RNF207 Gene

  • C1orf188

Previous GeneCards Identifiers for RNF207 Gene

  • GC01P006188
  • GC01P006265
  • GC01P005414

Summaries for RNF207 Gene

GeneCards Summary for RNF207 Gene

RNF207 (Ring Finger Protein 207) is a Protein Coding gene. GO annotations related to this gene include ion channel binding and Hsp70 protein binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF207 Gene

Genomics for RNF207 Gene

Regulatory Elements for RNF207 Gene

Promoters for RNF207 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RNF207 on UCSC Golden Path with GeneCards custom track

Genomic Location for RNF207 Gene

6,205,475 bp from pter
6,221,299 bp from pter
15,825 bases
Plus strand

Genomic View for RNF207 Gene

Genes around RNF207 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF207 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF207 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF207 Gene

Proteins for RNF207 Gene

  • Protein details for RNF207 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RING finger protein 207
    Protein Accession:
    Secondary Accessions:
    • A2VCM8
    • B4DFR6
    • Q5TGS6
    • Q6ZS63
    • Q96MP2

    Protein attributes for RNF207 Gene

    634 amino acids
    Molecular mass:
    70861 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAI28238.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RNF207 Gene


neXtProt entry for RNF207 Gene

Proteomics data for RNF207 Gene at MOPED

Post-translational modifications for RNF207 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RNF207 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RNF207 Gene

Domains & Families for RNF207 Gene

Gene Families for RNF207 Gene

Protein Domains for RNF207 Gene

Suggested Antigen Peptide Sequences for RNF207 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 B box-type zinc finger.
  • Contains 1 B box-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF207: view

Function for RNF207 Gene

Gene Ontology (GO) - Molecular Function for RNF207 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25281747
genes like me logo Genes that share ontologies with RNF207: view
genes like me logo Genes that share phenotypes with RNF207: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RNF207

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNF207 Gene

Localization for RNF207 Gene

Subcellular locations from

Jensen Localization Image for RNF207 Gene COMPARTMENTS Subcellular localization image for RNF207 gene
Compartment Confidence
cytosol 3
nucleus 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RNF207 Gene

Pathways & Interactions for RNF207 Gene

SuperPathways for RNF207 Gene

No Data Available

Interacting Proteins for RNF207 Gene

Gene Ontology (GO) - Biological Process for RNF207 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055117 regulation of cardiac muscle contraction ISS --
GO:0086019 cell-cell signaling involved in cardiac conduction ISS --
GO:1902261 positive regulation of delayed rectifier potassium channel activity IGI,IMP 25281747
GO:1903761 negative regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization ISS --
genes like me logo Genes that share ontologies with RNF207: view

No data available for Pathways by source and SIGNOR curated interactions for RNF207 Gene

Drugs & Compounds for RNF207 Gene

No Compound Related Data Available

Transcripts for RNF207 Gene

mRNA/cDNA for RNF207 Gene

Unigene Clusters for RNF207 Gene

Ring finger protein 207:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNF207 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14
SP1: - -
SP3: - -
SP4: -

Relevant External Links for RNF207 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNF207 Gene

mRNA expression in normal human tissues for RNF207 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNF207 Gene

This gene is overexpressed in Heart - Left Ventricle (x5.1) and Heart - Atrial Appendage (x4.4).

Protein differential expression in normal tissues from HIPED for RNF207 Gene

This gene is overexpressed in Spinal cord (67.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RNF207 Gene

SOURCE GeneReport for Unigene cluster for RNF207 Gene Hs.716549

genes like me logo Genes that share expression patterns with RNF207: view

Protein tissue co-expression partners for RNF207 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for RNF207 Gene

Orthologs for RNF207 Gene

This gene was present in the common ancestor of animals.

Orthologs for RNF207 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RNF207 35
  • 87.11 (n)
  • 86.56 (a)
RNF207 36
  • 84 (a)
(Canis familiaris)
Mammalia RNF207 35
  • 86.34 (n)
  • 83.71 (a)
RNF207 36
  • 83 (a)
(Mus musculus)
Mammalia Rnf207 35
  • 83.36 (n)
  • 82.83 (a)
Rnf207 16
Rnf207 36
  • 81 (a)
(Pan troglodytes)
Mammalia RNF207 35
  • 99.16 (n)
  • 98.74 (a)
RNF207 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Rnf207 35
  • 82.72 (n)
  • 83.15 (a)
(Monodelphis domestica)
Mammalia RNF207 36
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia RNF207 36
  • 71 (a)
(Gallus gallus)
Aves RNF207 35
  • 72.04 (n)
  • 64.75 (a)
RNF207 36
  • 65 (a)
(Anolis carolinensis)
Reptilia RNF207 36
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf207 35
  • 64.83 (n)
  • 65.21 (a)
(Danio rerio)
Actinopterygii rnf207b 35
  • 64.47 (n)
  • 62.06 (a)
RNF207 (2 of 2) 36
  • 54 (a)
rnf207b 36
  • 59 (a)
(Caenorhabditis elegans)
Secernentea F47G9.4 35
  • 41.23 (n)
  • 30.16 (a)
F47G9.4 36
  • 18 (a)
Species with no ortholog for RNF207:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RNF207 Gene

Gene Tree for RNF207 (if available)
Gene Tree for RNF207 (if available)

Paralogs for RNF207 Gene

No data available for Paralogs for RNF207 Gene

Variants for RNF207 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for RNF207 Gene

Genetic variation in RNF207 may influence the duration of QT interval, a mesure of cardiac repolarization that depends on multiple environmental and genetic contributors. Prolonged or shortened QT intervals predisposes to ventricular arrhythmias and are a risk factor for sudden cardiac death.

Sequence variations from dbSNP and Humsavar for RNF207 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs12073329 - 6,212,018(+) CCTTC(A/G)CAGAG nc-transcript-variant, reference, missense
rs709209 - 6,218,354(+) GAACA(A/G)CGCGG nc-transcript-variant, downstream-variant-500B, reference, missense
rs846111 - 6,219,310(-) AGAGG(C/G)CGTTC nc-transcript-variant, reference, missense
rs55823245 - 6,213,146(+) ACGTC(C/T)GCTCC nc-transcript-variant, reference, missense, utr-variant-3-prime
rs735385 -- 6,218,563(+) AAAAC(A/C)GGTGT intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for RNF207 Gene

Variant ID Type Subtype PubMed ID
nsv871698 CNV Loss 21882294
nsv870945 CNV Loss 21882294
dgv119n71 CNV Loss 21882294
nsv831425 CNV Loss 17160897
dgv120n71 CNV Loss 21882294
dgv121n71 CNV Loss 21882294
dgv8n67 CNV Gain 20364138
nsv508825 CNV Insertion 20534489

Variation tolerance for RNF207 Gene

Residual Variation Intolerance Score: 95.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.75; 86.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNF207 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for RNF207 Gene

Relevant External Links for RNF207

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RNF207 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF207 Gene

Publications for RNF207 Gene

  1. Common variants at ten loci modulate the QT interval duration in the QTSCD Study. (PMID: 19305409) Pfeufer A. … Chakravarti A. (Nat. Genet. 2009) 3 4 48 67
  2. Circulating E3 ligases are novel and sensitive biomarkers for diagnosis of acute myocardial infarction. (PMID: 25599194) Han Q.Y. … Li H.H. (Clin. Sci. 2015) 3
  3. Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization. (PMID: 24952745) Arking D.E. … Newton-Cheh C. (Nat. Genet. 2014) 3
  4. RING finger protein RNF207, a novel regulator of cardiac excitation. (PMID: 25281747) Roder K. … Koren G. (J. Biol. Chem. 2014) 3
  5. Common variants at ten loci influence QT interval duration in the QTGEN Study. (PMID: 19305408) Newton-Cheh C. … Stricker B.H. (Nat. Genet. 2009) 3

Products for RNF207 Gene

Sources for RNF207 Gene

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