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Aliases for RNF207 Gene

Aliases for RNF207 Gene

  • Ring Finger Protein 207 2 3
  • C1orf188 3 4
  • Chromosome 1 Open Reading Frame 188 2
  • OTTHUMG00000001089 2

External Ids for RNF207 Gene

Previous Symbols for RNF207 Gene

  • C1orf188

Summaries for RNF207 Gene

GeneCards Summary for RNF207 Gene

RNF207 (Ring Finger Protein 207) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF207 Gene

Genomics for RNF207 Gene

Genomic Location for RNF207 Gene

Start:
6,205,475 bp from pter
End:
6,221,299 bp from pter
Size:
15,825 bases
Orientation:
Plus strand

Genomic View for RNF207 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNF207 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF207 Gene

Regulatory Elements for RNF207 Gene

Proteins for RNF207 Gene

  • Protein details for RNF207 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZRF8-RN207_HUMAN
    Recommended name:
    RING finger protein 207
    Protein Accession:
    Q6ZRF8
    Secondary Accessions:
    • A2VCM8
    • B4DFR6
    • Q5TGS6
    • Q6ZS63
    • Q96MP2

    Protein attributes for RNF207 Gene

    Size:
    634 amino acids
    Molecular mass:
    70861 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI28238.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RNF207 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNF207 Gene

Proteomics data for RNF207 Gene at MOPED

Post-translational modifications for RNF207 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RNF207 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RNF207 Gene

Domains for RNF207 Gene

Gene Families for RNF207 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for RNF207 Gene

UniProtKB/Swiss-Prot:

RN207_HUMAN
Similarity:
  • Contains 1 B box-type zinc finger.:
    • Q6ZRF8
  • Contains 1 RING-type zinc finger.:
    • Q6ZRF8
genes like me logo Genes that share domains with RNF207: view

Function for RNF207 Gene

Gene Ontology (GO) - Molecular Function for RNF207 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25281747
GO:0008270 zinc ion binding IEA --
GO:0030544 Hsp70 protein binding IPI 25281747
GO:0044325 ion channel binding IPI 25281747
genes like me logo Genes that share ontologies with RNF207: view
genes like me logo Genes that share phenotypes with RNF207: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RNF207 Gene

Localization for RNF207 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNF207 Gene COMPARTMENTS Subcellular localization image for RNF207 gene
Compartment Confidence
nucleus 3
cytosol 2
golgi apparatus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RNF207 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005622 intracellular --
GO:0048471 perinuclear region of cytoplasm IMP 25281747
genes like me logo Genes that share ontologies with RNF207: view

Pathways for RNF207 Gene

SuperPathways for RNF207 Gene

No Data Available

Interacting Proteins for RNF207 Gene

Gene Ontology (GO) - Biological Process for RNF207 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0010628 positive regulation of gene expression IMP 25281747
GO:0055117 regulation of cardiac muscle contraction ISS --
GO:0086019 cell-cell signaling involved in cardiac conduction ISS --
GO:1901207 regulation of heart looping ISS --
genes like me logo Genes that share ontologies with RNF207: view

No data available for Pathways by source for RNF207 Gene

Transcripts for RNF207 Gene

mRNA/cDNA for RNF207 Gene

Unigene Clusters for RNF207 Gene

Ring finger protein 207:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNF207 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14
SP1: - -
SP2:
SP3: - -
SP4: -
SP5:

Relevant External Links for RNF207 Gene

GeneLoc Exon Structure for
RNF207
ECgene alternative splicing isoforms for
RNF207

Expression for RNF207 Gene

mRNA expression in normal human tissues for RNF207 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNF207 Gene

This gene is overexpressed in Heart - Left Ventricle (5.1) and Heart - Atrial Appendage (4.4).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for RNF207 Gene

SOURCE GeneReport for Unigene cluster for RNF207 Gene Hs.716549

genes like me logo Genes that share expressions with RNF207: view

Orthologs for RNF207 Gene

This gene was present in the common ancestor of animals.

Orthologs for RNF207 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNF207 36
  • 99.16 (n)
  • 98.74 (a)
RNF207 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RNF207 36
  • 87.11 (n)
  • 86.56 (a)
RNF207 37
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNF207 36
  • 86.34 (n)
  • 83.71 (a)
RNF207 37
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnf207 36
  • 83.36 (n)
  • 82.83 (a)
Rnf207 16
Rnf207 37
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RNF207 37
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RNF207 37
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnf207 36
  • 82.72 (n)
  • 83.15 (a)
chicken
(Gallus gallus)
Aves RNF207 36
  • 72.04 (n)
  • 64.75 (a)
RNF207 37
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RNF207 37
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf207 36
  • 64.83 (n)
  • 65.21 (a)
zebrafish
(Danio rerio)
Actinopterygii RNF207 (2 of 2) 37
  • 54 (a)
OneToMany
rnf207b 36
  • 64.47 (n)
  • 62.06 (a)
rnf207b 37
  • 59 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F47G9.4 36
  • 41.23 (n)
  • 30.16 (a)
F47G9.4 37
  • 18 (a)
OneToOne
Species with no ortholog for RNF207:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RNF207 Gene

ENSEMBL:
Gene Tree for RNF207 (if available)
TreeFam:
Gene Tree for RNF207 (if available)

Paralogs for RNF207 Gene

No data available for Paralogs for RNF207 Gene

Variants for RNF207 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for RNF207 Gene

Q6ZRF8-RN207_HUMAN
Genetic variation in RNF207 may influence the duration of QT interval, a mesure of cardiac repolarization that depends on multiple environmental and genetic contributors. Prolonged or shortened QT intervals predisposes to ventricular arrhythmias and are a risk factor for sudden cardiac death

Sequence variations from dbSNP and Humsavar for RNF207 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs709208 -- 6,212,077(-) CCCCC(C/T)CCGGC intron-variant
rs709209 - 6,218,354(+) GAACA(A/G)CGCGG reference, missense
rs735385 -- 6,218,563(+) AAAAC(A/C)GGTGT intron-variant
rs846111 - 6,219,310(-) AGAGG(C/G)CGTTC missense, reference
rs1052598 -- 6,211,065(-) AGCAG(C/T)GGCTC reference, synonymous-codon, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for RNF207 Gene

Variant ID Type Subtype PubMed ID
nsv871698 CNV Loss 21882294
nsv870945 CNV Loss 21882294
dgv119n71 CNV Loss 21882294
nsv831425 CNV Loss 17160897
dgv120n71 CNV Loss 21882294
dgv121n71 CNV Loss 21882294
dgv8n67 CNV Gain 20364138
nsv508825 CNV Insertion 20534489

Relevant External Links for RNF207 Gene

HapMap Linkage Disequilibrium report
RNF207
Human Gene Mutation Database (HGMD)
RNF207

Disorders for RNF207 Gene

Relevant External Links for RNF207

Genetic Association Database (GAD)
RNF207
Human Genome Epidemiology (HuGE) Navigator
RNF207
genes like me logo Genes that share disorders with RNF207: view

No data available for UniProtKB/Swiss-Prot for RNF207 Gene

Publications for RNF207 Gene

  1. Common variants at ten loci influence QT interval duration in the QTGEN Study. (PMID: 19305408) Newton-Cheh C. … Stricker B.H. (Nat. Genet. 2009) 3 4 49
  2. Common variants at ten loci modulate the QT interval duration in the QTSCD Study. (PMID: 19305409) Pfeufer A. … Chakravarti A. (Nat. Genet. 2009) 3 4 49
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3

Products for RNF207 Gene

Sources for RNF207 Gene

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