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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RNF207 Gene

protein-coding   GIFtS: 44
GCID: GC01P006265

Ring Finger Protein 207

(Previous name: chromosome 1 open reading frame 188)
(Previous symbol: C1orf188)
  Search for RNF207
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ring Finger Protein 2071 2
C1orf1881 2 3
OTTHUMG000000010891
Chromosome 1 Open Reading Frame 1881

External Ids:    HGNC: 329471   Entrez Gene: 3885912   Ensembl: ENSG000001582867   UniProtKB: Q6ZRF83   

Export aliases for RNF207 gene to outside databases

Previous GC identifers: GC01P006188 GC01P005414


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RNF207 Gene: 
RNF207 (ring finger protein 207) is a protein-coding gene. GO annotations related to this gene include zinc ion binding.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_021937.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RNF207 gene promoter:
         ER-alpha   GR   p53   GR-beta   Egr-1   Pax-2   MIF-1   Pax-2a   Egr-4   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNF207 promoter sequence
   Search SABiosciences Chromatin IP Primers for RNF207

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF207


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.31   Ensembl cytogenetic band:  1p36.31   HGNC cytogenetic band: 1p36.31

RNF207 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF207 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P006265:  view genomic region     (about GC identifiers)

Start:
6,265,535 bp from pter      End:
6,281,359 bp from pter
Size:
15,825 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RN207_HUMAN, Q6ZRF8 (See protein sequence)
Recommended Name: RING finger protein 207  
Size: 634 amino acids; 70861 Da
Sequence caution: Sequence=AAI28238.1; Type=Erroneous initiation;
Secondary accessions: A2VCM8 B4DFR6 Q5TGS6 Q6ZS63 Q96MP2
Alternative splicing: 4 isoforms:  Q6ZRF8-1   Q6ZRF8-2   Q6ZRF8-3   Q6ZRF8-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RNF207: NX_Q6ZRF8

Explore proteomics data for RNF207 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6ZRF8

  • RNF207 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RNF207 Protein Expression
    REFSEQ proteins: NP_997279.2  
    ENSEMBL proteins: 
     ENSP00000367173   ENSP00000367183  

    Human Recombinant Protein Products for RNF207: 
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    Cloud-Clone Corp. Proteins for RNF207 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IEA--

    RNF207 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RNF: RING-type (C3HC4) zinc fingers

    5 InterPro protein domains:
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR000315 Znf_B-box
     IPR018957 Znf_C3HC4_RING-type
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q6ZRF8

    ProtoNet protein and cluster: Q6ZRF8

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: RN207_HUMAN, Q6ZRF8
    Similarity: Contains 1 B box-type zinc finger
    Similarity: Contains 1 RING-type zinc finger


    RNF207 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
         
    RNF207 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for RNF207:
     Decreased viability of wild-ty  Increased HPV18 LCR reporter a  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RNF207 
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    SwitchGear 3'UTR luciferase reporter plasmidRNF207 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF207


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNF207

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RNF207 (RN207)

    Search CenterWatch for drugs/clinical trials and news about RNF207 / RN207

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RNF207 gene (2 alternative transcripts): 
    NM_173795.2  NM_207396.2  

    Unigene Cluster for RNF207:

    Ring finger protein 207
    Hs.716549  [show with all ESTs]
    Unigene Representative Sequence: NM_207396
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000466994(uc001amf.1) ENST00000484435 ENST00000377939(uc001amg.3)
    ENST00000485539(uc001amh.3) ENST00000496676(uc010nzp.1) ENST00000463453
    ENST00000496329 ENST00000492476 ENST00000483336 ENST00000377948
    miRNA
    Products:
         
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    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate RNF207 (see all 11):
    hsa-miR-1290 hsa-miR-513a-5p hsa-miR-27a hsa-miR-876-5p hsa-miR-548e hsa-miR-219-5p hsa-miR-3167 hsa-miR-508-3p
    SwitchGear 3'UTR luciferase reporter plasmidRNF207 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RNF207
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNF207
    Clone
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    OriGene clones in human, mouse for RNF207 (see all 7)
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    GenScript: all cDNA clones in your preferred vector: RNF207 (NM_207396)
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    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat RNF207
    Sirion Biotech Customized lentivirus for stable overexpression of RNF207 
                         Customized lentivirus expression plasmids for stable overexpression of RNF207 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for RNF207
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNF207
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNF207

    Additional mRNA sequence: 

    AK056658.1 AK127700.1 AK128246.1 AK294223.1 BC034459.1 BC119780.1 BC128237.1 

    13 DOTS entries:

    DT.95283915  DT.100790533  DT.87017640  DT.455022  DT.40255952  DT.92005193  DT.70102874  DT.121366453 
    DT.91677288  DT.405841  DT.86855797  DT.100790540  DT.121366420 

    10 AceView cDNA sequences:

    AI474487 AI620515 BF510516 BM669545 CD673733 BM310807 AK128246 BM698769 
    BM310499 NM_207396 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for RNF207    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14
    SP1:              -     -                                                                                       
    SP2:                                                                                                            
    SP3:                                                                                -           -               
    SP4:                                                                                -                           
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for RNF207

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RNF207 expression in normal human tissues (normalized intensities)      RNF207 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAGGATGAG
    RNF207 Expression
    About this image


    RNF207 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Eye (Sensory Organs)
             Mature Rod Cells Outer Nuclear Layer
     
     Heart (Cardiovascular System)

    See RNF207 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RNF207

    SOURCE GeneReport for Unigene cluster: Hs.716549
        SABiosciences Expression via Pathway-Focused PCR Array including RNF207: 
              Ubiquitin Ligases in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF207

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RNF207 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnf2071 , 5 ring finger protein 2071, 5 83.36(n)1
    82.83(a)1
      4 (83.02 cM)5
    4338091  NM_001033489.21  NP_001028661.21 
     1523070195 
    chicken
    (Gallus gallus)
    Aves RNF2071 ring finger protein 207 71.38(n)
    64.23(a)
      419374  XM_417536.3  XP_417536.2 
    lizard
    (Anolis carolinensis)
    Reptilia RNF2076
    ring finger protein 207
    64(a)
    1 ↔ 1
    AAWZ02035903(23888-35075)
    zebrafish
    (Danio rerio)
    Actinopterygii rnf207b1 ring finger protein 207b 64.26(n)
    61.74(a)
      568322  NM_001201449.1  NP_001188378.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F47G9.41 Protein F47G9.4 40.54(n)
    29.02(a)
      179566  NM_073475.2  NP_505876.1 


    ENSEMBL Gene Tree for RNF207 (if available)
    TreeFam Gene Tree for RNF207 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: RN207_HUMAN, Q6ZRF8
    Polymorphism: Genetic variation in RNF207 may influence the duration of QT interval, a mesure of cardiac
    repolarization that depends on multiple environmental and genetic contributors. Prolonged or shortened QT
    intervals predisposes to ventricular arrhythmias and are a risk factor for sudden cardiac death


    10/413 SNPs in RNF207 are shown (see all 413)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1909533401,2
    --6264243(+) CCCAGA/GAGGCG 1 -- us2k10--------
    rs342760481,2
    C--6264315(+) AAAAA-/AGAACC 1 -- us2k10--------
    rs2020079961,2
    C--6264330(-) TGGTTC/TTNNNN 1 -- us2k10--------
    rs1831421051,2
    --6264388(+) CACTTC/TCTTCT 1 -- us2k10--------
    rs563948361,2
    C--6264410(+) CCTACC/TCCTAC 1 -- us2k10--------
    rs1163092551,2
    F--6264451(+) CAAGGC/TGGCTC 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1876867691,2
    --6264544(+) CAGCAA/GAACCC 1 -- us2k10--------
    rs356231361,2
    C--6264597(+) AATAC-/A/AAA 
            
    AAAAA
    2 -- us2k1 cds12NA 4
    rs1133875861,2
    C--6264666(+) GGCCAA/GGGTGG 1 -- us2k10--------
    rs43149001,2
    C--6264757(+) TAGCCA/GGGCAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RNF207 (6265535 - 6281359 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for RNF207:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv508825CNV Insertion20534489
    nsv871698CNV Loss21882294
    dgv121n71CNV Loss21882294
    dgv120n71CNV Loss21882294
    nsv870945CNV Loss21882294
    nsv831425CNV Loss17160897
    dgv119n71CNV Loss21882294
    dgv8n67CNV Gain20364138

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing RNF207
    DNA2.0 Custom Variant and Variant Library Synthesis for RNF207

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    RNF207 for disorders           About MalaCards

    RNF207 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RNF207
    Human Genome Epidemiology (HuGE) Navigator: RNF207 (2 documents)

    Export disorders for RNF207 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RNF207 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with RNF207)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Common variants at ten loci modulate the QT interval duration in the QTSCD Study. (PubMed id 19305409)1, 2, 4 Pfeufer A....Chakravarti A. (2009)
    2. Common variants at ten loci influence QT interval duration in the QTGEN Study. (PubMed id 19305408)1, 2, 4 Newton-Cheh C....Stricker B.H. (2009)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    7. Expressed sequence tag analysis of adult human lens for the NEIBank project: over 2000 non-redundant transcripts, novel genes and splice variants. (PubMed id 12107413)1 Wistow G.... Peterson K. (2002)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 388591 HGNC: 32947 AceView: FLJ46380 Ensembl:ENSG00000158286 euGenes: HUgn388591
    ECgene: RNF207 H-InvDB: RNF207

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RNF207 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RNF207 gene:
    Search GeneIP for patents involving RNF207

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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