RNF207 Gene
protein-coding GIFtS : 43
GCID: GC01 P006265
ring finger protein 207 (Previous name: chromosome 1 open reading frame 188 ) (Previous symbol: C1orf188 )
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Aliasesfor RNF207 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Ring Finger Protein 207 1 2 C1orf1881 2 3 FLJ320961 FLJ463801 Chromosome 1 Open Reading Frame 1881
Export aliases for RNF207 gene to outside databases Previous GC identifers: GC01P006188 GC01P005414
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Summariesfor RNF207 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section --
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Genomic Viewsfor RNF207 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000001.10 NC_018912.1 NT_021937.19 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the RNF207 gene promoter: ER-alpha GR p53 GR-beta Egr-1 Pax-2 MIF-1 Pax-2a Egr-4 GR-alpha Other transcription factors Search SABiosciences Chromatin IP Primers for RNF207 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat RNF207
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 1p36.31 Ensembl cytogenetic band: 1p36.31 HGNC cytogenetic band: 1p36.31 RNF207 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01P006265: view genomic region
(about GC identifiers )
Start:
6,265,535 bp from pter
End:
6,281,359 bp from pter
Size:
15,825 bases
Orientation:
plus strand
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Proteinsfor RNF207 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: RN207_HUMAN, Q6ZRF8 (See
protein sequence )Recommended Name: RING finger protein 207 Size : 634 amino acids; 70861 Da
Sequence caution : Sequence=AAI28238.1; Type=Erroneous initiation;
Secondary accessions : A2VCM8 B4DFR6 Q5TGS6 Q6ZS63 Q96MP2Alternative splicing : 4 isoforms : Q6ZRF8-1 Q6ZRF8-2 Q6ZRF8-3 Q6ZRF8-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for RNF207: NX_Q6ZRF8 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q6ZRF8 RNF207 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_997279.2 ENSEMBL proteins: ENSP00000367173 ENSP00000367183 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005622 intracellular
IEA --
RNF207 for ontologies About GeneDecksing RNF207 Antibody Products: Assay Products for RNF207:
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Protein
Domains / Familiesfor RNF207 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
RNF207 for domains About GeneDecksing 5 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q6ZRF8 ProtoNet protein and cluster: Q6ZRF8
1 Blocks protein family : IPB001841 Zn-finger UniProtKB/Swiss-Prot: RN207_HUMAN, Q6ZRF8 Similarity : Contains 1 B box-type zinc fingerSimilarity : Contains 1 RING-type zinc finger
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Functionfor RNF207 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for RNF207 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for RNF207OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: RNF207 (NM_207396 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RNF207 Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat RNF207
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF207
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0008270 zinc ion binding
IEA --
RNF207 for ontologies About GeneDecksing 3 GenomeRNAi human phenotypes for RNF207 :
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Pathways & Interactionsfor RNF207 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNF207
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Drugs & Compoundsfor RNF207 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for RNF207 Search CenterWatch for drugs/clinical trials and news about RNF207 / RN207
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Transcriptsfor RNF207 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
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siRNAs from
OriGene ,
QIAGEN ,
shRNA from
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microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
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Primers from
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QIAGEN
)About This Section REFSEQ mRNAs for RNF207 gene (2 alternative transcripts): NM_173795.2 NM_207396.2 Unigene Cluster for RNF207:
Ring finger protein 207 Hs.716549 [show with all ESTs ] Unigene Representative Sequence: NM_207396 10 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000466994 (uc001amf.1 ) ENST00000484435 ENST00000377939 (uc001amg.3 )ENST00000485539 (uc001amh.3 ) ENST00000496676 (uc010nzp.1 ) ENST00000463453 ENST00000496329 ENST00000492476 ENST00000483336 ENST00000377948 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for RNF207 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for RNF207OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: RNF207 (NM_207396 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RNF207 Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat RNF207
Additional cDNA sequence: AK056658.1 AK127700.1 AK128246.1 AK294223.1 BC034459.1 BC119780.1 BC128237.1
12 DOTS entries : DT.95283915 DT.100790533
DT.455022 DT.40255952 DT.92005193 DT.87017640 DT.70102874 DT.121366453 DT.91677288 DT.405841 DT.121366420 DT.100790540 10 AceView cDNA sequences :
CD673733 BM669545 AI474487 BF510516 AI620515 BM310499 BM698769 AK128246 NM_207396 BM310807 GeneLoc Exon Structure 5 Alternative Splicing Database (ASD) splice patterns (SP) for RNF207 About this scheme ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 SP1 :     -   -                               SP2 :                                     SP3 :                           -     -       SP4 :                           -           SP5 :                                    
ECgene alternative splicing isoforms for RNF207
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Expression for RNF207 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section RNF207 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GAAGGATGAG
About this image RNF207 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table 1 LifeMap In Vivo Development Anatomical Compartment/Cell Tissue Anatomical Compartment
Cell Category (developmental path) Eye Outer Nuclear Layer Mature Rod Cells Photoreceptors, Retina Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See RNF207 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for RNF207 SOURCE GeneReport for Unigene cluster: Hs.716549 SABiosciences Expression via Pathway-Focused PCR Array including RNF207 : Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for RNF207Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat RNF207 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat RNF207 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat RNF207 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF207
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Orthologsfor RNF207 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for RNF207 gene from 6/15 species (see all 15 ) About this table
ENSEMBL Gene Tree for RNF207 (if available)TreeFam Gene Tree for RNF207 (if available)
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Paralogsfor RNF207 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section --
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Genomic Variantsfor RNF207 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section UniProtKB/Swiss-Prot: RN207_HUMAN, Q6ZRF8 Polymorphism : Genetic variation in RNF207 may influence the duration of QT interval, a mesure of cardiac repolarizationthat depends on multiple environmental and genetic contributors. Prolonged or shortened QT intervals predisposes to ventricular arrhythmias and are a risk factor for sudden cardiac death
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 1 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for RNF207 (6265535 - 6281359 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for RNF207 1 CNV : 4200
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing RNF207
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Disorders
/ Diseasesfor RNF207 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section RNF207 for disorders About MalaCards
RNF207 for disorders About GeneDecksing Human Genome Epidemiology (HuGE) Navigator: RNF207 (2 documents) Export disorders for RNF207 gene to outside databases
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Publicationsfor RNF207 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for RNF207 gene integrated from 9 sources : (articles sorted by number of sources associating them with RNF207) Utopia : connect your pdf to the dynamic world of online information
Common variants at ten loci modulate the QT interval duration in the QTSCD Study. (PubMed id 19305409) 1 , 2 Pfeufer A....Chakravarti A. (2009) Common variants at ten loci influence QT interval duration in the QTGEN Study. (PubMed id 19305408) 1 , 2 Newton-Cheh C....Stricker B.H. (2009) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560) 1 Kimura K.... Sugano S. (2006) The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414) 2 Gregory S.G.... Bentley D.R. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) Expressed sequence tag analysis of adult human lens for the NEIBank project: over 2000 non-redundant transcripts, novel genes and splice variants. (PubMed id 12107413) 1 Wistow G.... Peterson K. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548) 1 Bonaldo M.F.... Soares M.B. (1996)
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External Searches for RNF207 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing RNF207 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing RNF207 gene
(According to HUGE )
About This Section --
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Specialized Databases showing RNF207 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for RNF207 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for RNF207 gene: Search GeneIP for patents involving RNF207 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor RNF207 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for RNF207 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for RNF207 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for RNF207 OriGene Protein Over-expression Lysate for RNF207 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for RNF207 OriGene 3'-UTR Clone for RNF207 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for RNF207 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for RNF207 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for RNF207 OriGene Custom Protein Services for RNF207 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RNF207 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing RNF207 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat RNF207 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat RNF207 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat RNF207 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat RNF207
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