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RNF20 Gene

protein-coding   GIFtS: 55
GCID: GC09P104296

Ring Finger Protein 20, E3 Ubiquitin Protein Ligase

(Previous name: ring finger protein 20)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ring Finger Protein 20, E3 Ubiquitin Protein Ligase1 2     BRE12
RING Finger Protein 201 3     BRE1 E3 Ubiquitin Ligase Homolog2
BRE1-A2 3     E3 Ubiquitin-Protein Ligase BRE1A2
BRE1A2 3     Homolog Of S. Cerevisiae BRE12
hBRE12 3     EC 6.3.2.-3
BRE1 E3 Ubiquitin Ligase Homolog (S. Cerevisiae)1     EC 6.3.28

External Ids:    HGNC: 100621   Entrez Gene: 562542   Ensembl: ENSG000001558277   OMIM: 6076995   UniProtKB: Q5VTR23   

Export aliases for RNF20 gene to outside databases

Previous GC identifers: GC09P095096 GC09P096039 GC09P097753 GC09P099675 GC09P101375 GC09P103335 GC09P073896


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RNF20 Gene:
The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. The protein encoded by this human
gene is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B. This
protein acts as a putative tumor suppressor and positively regulates the p53 tumor suppressor as well as numerous
histone H2A and H2B genes. In contrast, this protein also suppresses the expression of several protooncogenes and
growth-related genes, including many genes that are induced by epidermal growth factor. This gene selectively
suppresses the expression of some genes by interfering with chromatin recruitment of transcription elongation
factor SII (TFIIS). (provided by RefSeq, Feb 2012)

GeneCards Summary for RNF20 Gene:
RNF20 (ring finger protein 20, E3 ubiquitin protein ligase) is a protein-coding gene. Diseases associated with RNF20 include parathyroid carcinoma, and bladder transitional cell carcinoma. GO annotations related to this gene include transcription coactivator activity and chromatin binding. An important paralog of this gene is RNF40.

UniProtKB/Swiss-Prot: BRE1A_HUMAN, Q5VTR2
Function: Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of
'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation
and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It
thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin
ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH
are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably
by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator

Gene Wiki entry for RNF20 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the RNF20 gene promoter:
         AML1a   MEF-2   Pax-2   Pax-2a   MEF-2A   Nkx6-1   aMEF-2   NF-Y   CBF(2)   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNF20 promoter sequence
   Search Chromatin IP Primers for RNF20

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNF20


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22   Ensembl cytogenetic band:  9q31.1   HGNC cytogenetic band: 9q22

RNF20 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF20 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P104296:  view genomic region     (about GC identifiers)

Start:
104,296,133 bp from pter      End:
104,325,626 bp from pter
Size:
29,494 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: BRE1A_HUMAN, Q5VTR2 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase BRE1A  
Size: 975 amino acids; 113662 Da
Subunit: Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of
RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6. Interacts with p53/TP53 and WAC. Interacts
with PAF1; the interaction mediates the association of the PAF1 and RNF20/40 complexes which is a prerequsite for
recruitment of UBE2A/B
Sequence caution: Sequence=AAH63115.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=BAA91326.1; Type=Erroneous initiation; Sequence=BAA92057.1; Type=Erroneous initiation;
Sequence=BAB14005.1; Type=Erroneous initiation;
Secondary accessions: A7MCT5 Q2TB34 Q69YL5 Q6P527 Q8N3J4 Q96JD3 Q9H9Y7 Q9HA51 Q9NUR4 Q9NWQ3
Q9NX83

Explore the universe of human proteins at neXtProt for RNF20: NX_Q5VTR2

Explore proteomics data for RNF20 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys194, Lys242, Lys762, Lys821
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for RNF20 (Q5VTR2) (see all 25)
     DFHRIYI  KKLRTEV  LLIVNRYW  AAQLADDLK 


    See RNF20 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_062538.5  
    ENSEMBL proteins: 
     ENSP00000373772   ENSP00000363952   ENSP00000419201   ENSP00000418924  

    RNF20 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for RNF20
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    Novus Biologicals RNF20 Protein
    Novus Biologicals RNF20 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RNF20

    RNF20 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of RNF20
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    ThermoFisher Antibodies for RNF20
    LSBio Antibodies in human, mouse, rat for RNF20

    RNF20 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for RNF20
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RNF20
    Cloud-Clone Corp. CLIAs for RNF20


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers

    4 InterPro protein domains:
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR018957 Znf_C3HC4_RING-type
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q5VTR2

    ProtoNet protein and cluster: Q5VTR2

    UniProtKB/Swiss-Prot: BRE1A_HUMAN, Q5VTR2
    Similarity: Belongs to the BRE1 family
    Similarity: Contains 1 RING-type zinc finger


    RNF20 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BRE1A_HUMAN, Q5VTR2
    Function: Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of
    'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation
    and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It
    thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin
    ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH
    are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably
    by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator

         Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002039p53 binding IDA16337599
    GO:0003682chromatin binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity ----
    GO:0003713transcription coactivator activity IDA16337599
    GO:0004842contributes to ubiquitin-protein ligase activity IDA16307923
         
    RNF20 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for RNF20:
     Decreased Hepatitis C virus re  Increased cell death HMECs cel  Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RNF20
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RNF20

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RNF20
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RNF20

    miRNA
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    miRTarBase miRNAs that target RNF20:
    hsa-mir-1296-5p (MIRT036112), hsa-mir-221-3p (MIRT024169)

    Block miRNA regulation of human, mouse, rat RNF20 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RNF20 (see all 13):
    hsa-miR-98 hsa-miR-875-3p hsa-let-7d hsa-let-7c hsa-miR-7 hsa-let-7i hsa-let-7g hsa-let-7e
    SwitchGear 3'UTR luciferase reporter plasmidRNF20 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RNF20
    Predesigned siRNA for gene silencing in human, mouse, rat RNF20

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for RNF20

    Clone
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    OriGene clones in human, mouse for RNF20 (see all 7)
    OriGene ORF clones in mouse, rat for RNF20
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RNF20 (NM_019592)
    Sino Biological Human cDNA Clone for RNF20
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNF20
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF20

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF20


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BRE1A_HUMAN, Q5VTR2: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex IDA16307923
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0033503HULC complex IDA19410543

    RNF20 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RNF20 About    
    See pathways by source

    SuperPathContained pathways About
    1Packaging Of Telomere Ends
    Histone modification0.31
    2Protein Stability
    Protein Stability
    3Chromatin Regulation / Acetylation
    Chromatin Regulation / Acetylation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for RNF20
        Chromatin Regulation / Acetylation
    Protein Stability



    UniProtKB/Swiss-Prot: BRE1A_HUMAN, Q5VTR2
    Pathway: Protein modification; protein ubiquitination


    RNF20 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including RNF20: 

              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RNF20

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RNF20 (Q5VTR21, 2, 3 ENSP000003737724) via UniProtKB, MINT, STRING, and/or I2D (see all 280)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COPS5Q929051, 2, 3, ENSP000003505124EBI-2372238,EBI-594661 MINT-7230300 MINT-7230284 MINT-7230242 I2D: score=1 STRING: ENSP00000350512
    RNF40O751501, 2, 3, ENSP000003256774EBI-2372238,EBI-744408 MINT-8387176 I2D: score=2 STRING: ENSP00000325677
    PSMD14O004872, ENSP000003865414MINT-7230300 MINT-7230242 STRING: ENSP00000386541
    SLX4IPQ5VYV73, ENSP000003355574I2D: score=2 STRING: ENSP00000335557
    TP53P046373, ENSP000002693054I2D: score=2 STRING: ENSP00000269305
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000209protein polyubiquitination IDA19037095
    GO:0006355regulation of transcription, DNA-templated IMP18832071
    GO:0006511ubiquitin-dependent protein catabolic process IMP19037095
    GO:0007165signal transduction ----
    GO:0010390histone monoubiquitination IDA16307923

    RNF20 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RNF20 (BRE1A)

    4 HMDB Compounds for RNF20    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RNF20 gene: 
    NM_019592.6  

    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000389120(uc004bbn.3) ENST00000374819 ENST00000479306 ENST00000481046
    ENST00000466817 ENST00000478072
    miRNA
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    Block miRNA regulation of human, mouse, rat RNF20 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RNF20 (see all 13):
    hsa-miR-98 hsa-miR-875-3p hsa-let-7d hsa-let-7c hsa-miR-7 hsa-let-7i hsa-let-7g hsa-let-7e
    SwitchGear 3'UTR luciferase reporter plasmidRNF20 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RNF20
    Clone
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    OriGene ORF clones in mouse, rat for RNF20
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RNF20 (NM_019592)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF20
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for RNF20
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RNF20
      QuantiTect SYBR Green Assays in human, mouse, rat RNF20
      QuantiFast Probe-based Assays in human, mouse, rat RNF20

    Selected AceView cDNA sequences (see all 135):

    AK000697 BE315256 BE383022 AA233016 BM468058 BM452672 CD690884 AK022300 
    AI263659 AW074567 BM474117 BC016691 NM_019592 AU121911 AK000389 BC063115 
    BP343322 AI915826 BU509798 AL834272 BG288880 AA228050 BQ186245 AL832910 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RNF20 (see all 14)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c · 9d · 9e ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:        -     -     -                 -                                                                                                                     
    SP4:        -     -     -                 -                                                                                                                     
    SP5:        -     -     -                 -                                               -                                                                     

    ExUns: 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23a · 23b ^ 24 ^ 25
    SP1:                                                        -                 -               
    SP2:                                                                                          
    SP3:                                                                                          
    SP4:                                                                                          
    SP5:                                                                                          


    ECgene alternative splicing isoforms for RNF20

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RNF20 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    RNF20 Expression
    About this image


    RNF20 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Limb (Muscoskeletal System)
             Limb Bud
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    RNF20 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RNF20 Protein Expression
        Pathway & Disease-focused RT2 Profiler PCR Arrays including RNF20: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RNF20
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    QuantiFast Probe-based Assays in human, mouse, rat RNF20
    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF20

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RNF20 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnf201 , 5 ring finger protein 201, 5 90.34(n)1
    97.84(a)1
      4 (26.69 cM)5
    1093311  NM_001163263.11  NP_001156735.11 
     496320065 
    chicken
    (Gallus gallus)
    Aves RNF201 ring finger protein 20, E3 ubiquitin protein ligase 79.77(n)
    90.04(a)
      427310  NM_001031434.1  NP_001026605.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    97(a)
    85(a)
    many → 1
    many → 1
    2(64667595-64677384)
    2(64685422-64709908)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.4442 Transcribed sequence with weak similarity to protein more 77.36(n)    141998056 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.62442 Danio rerio, Similar to ring finger protein 20, clone more 76.15(n)    BC044539.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG105423   -- 46(a)   64E8   --
    worm
    (Caenorhabditis elegans)
    Secernentea R05D3.43   -- 26(a)   III(8430362-8433823)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes BRE16
    E3 ubiquitin ligase, forms heterodimer with Rad6p ...
    21(a)
    1 → many
    IV(324047-326149) YDL074C


    ENSEMBL Gene Tree for RNF20 (if available)
    TreeFam Gene Tree for RNF20 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RNF20 gene
    RNF402  
    1 SIMAP similar gene for RNF20 using alignment to 6 protein entries:     BRE1A_HUMAN (see all proteins):
    RNF40

    RNF20 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RNF20 (see all 667)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs745901361,2
    C--104294207(+) GGATTA/TTGGTA 1 -- us2k10--------
    rs1431559271,2
    --104294208(+) GATTAC/TGGTAA 1 -- us2k10--------
    rs1474967371,2
    --104294218(+) AACAAA/GAATAA 1 -- us2k10--------
    rs70408631,2
    C,F,A,H--104294250(+) AGCCAC/TGCCAA 1 -- us2k14Minor allele frequency- T:0.01NS EA 418
    rs1864932691,2
    --104294300(+) TAATCC/TCAGCA 1 -- us2k10--------
    rs1429616011,2
    --104294324(+) AGGTGA/GATGGA 1 -- us2k10--------
    rs625758361,2
    C,F--104294335(+) TCGTCC/TGAGGT 1 -- us2k17Minor allele frequency- T:0.09NA WA CSA EA 366
    rs625758371,2
    C,F--104294356(+) AGACCG/AGCCTA 1 -- us2k17Minor allele frequency- A:0.08NA WA CSA EA 366
    rs1921764461,2
    C--104294373(+) ATGGCA/GAAACC 1 -- us2k10--------
    rs625758381,2
    C,F--104294530(+) CTGGGC/TGACAG 1 -- us2k15Minor allele frequency- T:0.50NA WA CSA 10

    HapMap Linkage Disequilibrium report for RNF20 (104296133 - 104325626 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for RNF20:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv893626CNV Loss21882294
    nsv893627CNV Loss21882294
    nsv831672CNV Gain17160897

    Human Gene Mutation Database (HGMD): RNF20
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RNF20
    DNA2.0 Custom Variant and Variant Library Synthesis for RNF20

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607699    OMIM disorders: --

    14 diseases for RNF20:    
    About MalaCards
    parathyroid carcinoma    bladder transitional cell carcinoma    transitional cell carcinoma    kawasaki disease
    fanconi's anemia    retinoblastoma    tonsillitis    colorectal cancer
    prostatitis    prostate cancer    thyroiditis    cerebritis
    leukemia    endotheliitis


    RNF20 for disorders           About GeneDecksing


    Export disorders for RNF20 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RNF20 gene, integrated from 10 sources (see all 65):
    (articles sorted by number of sources associating them with RNF20)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human homolog of yeast BRE1 functions as a transcriptional coactivator through direct activator interactions. (PubMed id 16337599)1, 2, 3 Kim J.... Roeder R.G. (Mol. Cell 2005)
    2. The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression. (PubMed id 18832071)1, 3, 9 Shema E....Oren M. (amp 2008)
    3. WAC, a functional partner of RNF20/40, regulates histone H2B ubiquitination and gene transcription. (PubMed id 21329877)1, 2 Zhang F. and Yu X. (Mol. Cell 2011)
    4. RAD6-mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cells. (PubMed id 19410543)1, 2 Kim J.... Roeder R.G. (Cell 2009)
    5. Human BRE1 is an E3 ubiquitin ligase for Ebp1 tumor suppressor. (PubMed id 19037095)1, 3 Liu Z....Ye K. (Mol. Biol. Cell 2009)
    6. Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. (PubMed id 16307923)1, 2 Zhu B.... Reinberg D. (Mol. Cell 2005)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. The Paf1 complex is essential for histone monoubiquitination by the Rad6-Bre1 complex, which signals for histone methylation by COMPASS and Dot1p. (PubMed id 12876294)1, 3 Wood A....Shilatifard A. (J. Biol. Chem. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 56254 HGNC: 10062 AceView: RNF20 Ensembl:ENSG00000155827 euGenes: HUgn56254
    ECgene: RNF20 H-InvDB: RNF20

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RNF20 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RNF20 gene:
    Search GeneIP for patents involving RNF20

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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