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Aliases for RNF20 Gene

Aliases for RNF20 Gene

  • Ring Finger Protein 20, E3 Ubiquitin Protein Ligase 2 3
  • BRE1-A 3 4
  • BRE1A 3 4
  • HBRE1 3 4
  • BRE1 E3 Ubiquitin Ligase Homolog (S. Cerevisiae) 2
  • E3 Ubiquitin-Protein Ligase BRE1A 3
  • BRE1 E3 Ubiquitin Ligase Homolog 3
  • Homolog Of S. Cerevisiae BRE1 3
  • Ring Finger Protein 20 2
  • RING Finger Protein 20 4
  • EC 6.3.2.- 4
  • EC 6.3.2 64
  • BRE1 3

External Ids for RNF20 Gene

Summaries for RNF20 Gene

Entrez Gene Summary for RNF20 Gene

  • The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. The protein encoded by this human gene is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B. This protein acts as a putative tumor suppressor and positively regulates the p53 tumor suppressor as well as numerous histone H2A and H2B genes. In contrast, this protein also suppresses the expression of several protooncogenes and growth-related genes, including many genes that are induced by epidermal growth factor. This gene selectively suppresses the expression of some genes by interfering with chromatin recruitment of transcription elongation factor SII (TFIIS). [provided by RefSeq, Feb 2012]

GeneCards Summary for RNF20 Gene

RNF20 (Ring Finger Protein 20, E3 Ubiquitin Protein Ligase) is a Protein Coding gene. Among its related pathways are Protein Stability and Chromatin Regulation / Acetylation. GO annotations related to this gene include chromatin binding and transcription coactivator activity. An important paralog of this gene is RNF40.

UniProtKB/Swiss-Prot for RNF20 Gene

  • Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of Lys-120 of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 Lys-4 and Lys-79 methylation (H3K4me and H3K79me, respectively). It thereby plays a central role inb histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator. Mediates the polyubiquitination of isoform 2 of PA2G4 in cancer cells leading to its proteasome-mediated degradation.

Gene Wiki entry for RNF20 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF20 Gene

Genomics for RNF20 Gene

Genomic Location for RNF20 Gene

Start:
101,533,849 bp from pter
End:
101,563,344 bp from pter
Size:
29,496 bases
Orientation:
Plus strand

Genomic View for RNF20 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNF20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF20 Gene

Regulatory Elements for RNF20 Gene

Proteins for RNF20 Gene

  • Protein details for RNF20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VTR2-BRE1A_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase BRE1A
    Protein Accession:
    Q5VTR2
    Secondary Accessions:
    • A7MCT5
    • Q2TB34
    • Q69YL5
    • Q6P527
    • Q8N3J4
    • Q96JD3
    • Q9H9Y7
    • Q9HA51
    • Q9NUR4
    • Q9NWQ3
    • Q9NX83

    Protein attributes for RNF20 Gene

    Size:
    975 amino acids
    Molecular mass:
    113662 Da
    Quaternary structure:
    • Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6. Interacts with p53/TP53 and WAC. Interacts with PAF1; the interaction mediates the association of the PAF1 and RNF20/40 complexes which is a prerequsite for recruitment of UBE2A/B. Interacts with isoform 1 and isoform 2 of PA2G4.
    SequenceCaution:
    • Sequence=AAH63115.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA91326.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA92057.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14005.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for RNF20 Gene

Proteomics data for RNF20 Gene at MOPED

Post-translational modifications for RNF20 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys194, Lys242, Lys762, and Lys821

Other Protein References for RNF20 Gene

Domains for RNF20 Gene

Gene Families for RNF20 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for RNF20 Gene

UniProtKB/Swiss-Prot:

BRE1A_HUMAN
Family:
  • Belongs to the BRE1 family.:
    • Q5VTR2
Similarity:
  • Contains 1 RING-type zinc finger.:
    • Q5VTR2
genes like me logo Genes that share domains with RNF20: view

Function for RNF20 Gene

Molecular function for RNF20 Gene

UniProtKB/Swiss-Prot Function: Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of Lys-120 of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 Lys-4 and Lys-79 methylation (H3K4me and H3K79me, respectively). It thereby plays a central role inb histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator. Mediates the polyubiquitination of isoform 2 of PA2G4 in cancer cells leading to its proteasome-mediated degradation.

Enzyme Numbers (IUBMB) for RNF20 Gene

Gene Ontology (GO) - Molecular Function for RNF20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002039 p53 binding IDA 16337599
GO:0003682 chromatin binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity --
GO:0003713 transcription coactivator activity IDA 16337599
GO:0003730 mRNA 3-UTR binding IDA 19575011
genes like me logo Genes that share ontologies with RNF20: view
genes like me logo Genes that share phenotypes with RNF20: view

miRNA for RNF20 Gene

miRTarBase miRNAs that target RNF20

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for RNF20 Gene

Localization for RNF20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF20 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNF20 Gene COMPARTMENTS Subcellular localization image for RNF20 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for RNF20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IDA 16307923
GO:0005634 nucleus IDA 16307923
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA 19037095
GO:0033503 HULC complex IDA 19410543
genes like me logo Genes that share ontologies with RNF20: view

Pathways for RNF20 Gene

genes like me logo Genes that share pathways with RNF20: view

Pathways by source for RNF20 Gene

2 Cell Signaling Technology pathways for RNF20 Gene

UniProtKB/Swiss-Prot Q5VTR2-BRE1A_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for RNF20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IDA 19037095
GO:0006355 regulation of transcription, DNA-templated IMP 18832071
GO:0006511 ubiquitin-dependent protein catabolic process IMP 19037095
GO:0007165 signal transduction --
GO:0007346 NOT regulation of mitotic cell cycle IMP 19575011
genes like me logo Genes that share ontologies with RNF20: view

Compounds for RNF20 Gene

(4) HMDB Compounds for RNF20 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
61-19-8
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2
Pyrophosphate
  • (4-)Diphosphoric acid ion
14000-31-8
genes like me logo Genes that share compounds with RNF20: view

Transcripts for RNF20 Gene

Unigene Clusters for RNF20 Gene

Ring finger protein 20, E3 ubiquitin protein ligase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNF20 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c · 9d · 9e ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^
SP1:
SP2:
SP3: - - - -
SP4: - - - -
SP5: - - - - -
SP6: - -
SP7:
SP8:
SP9: - - -
SP10: - -
SP11:
SP12: -
SP13:
SP14:

ExUns: 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23a · 23b ^ 24 ^ 25
SP1: - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for RNF20 Gene

GeneLoc Exon Structure for
RNF20
ECgene alternative splicing isoforms for
RNF20

Expression for RNF20 Gene

mRNA expression in normal human tissues for RNF20 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RNF20 Gene

SOURCE GeneReport for Unigene cluster for RNF20 Gene Hs.729085

mRNA Expression by UniProt/SwissProt for RNF20 Gene

Q5VTR2-BRE1A_HUMAN
Tissue specificity: Expressed in the normal brain and also in malignant gliomas (at protein level).
genes like me logo Genes that share expressions with RNF20: view

Orthologs for RNF20 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RNF20 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNF20 36
  • 99.69 (n)
  • 100 (a)
RNF20 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RNF20 36
  • 92.51 (n)
  • 98.05 (a)
RNF20 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNF20 36
  • 92.79 (n)
  • 98.46 (a)
RNF20 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnf20 36
  • 90.34 (n)
  • 97.84 (a)
Rnf20 16
Rnf20 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RNF20 37
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RNF20 37
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnf20 36
  • 89 (n)
  • 97.23 (a)
chicken
(Gallus gallus)
Aves RNF20 36
  • 79.77 (n)
  • 90.04 (a)
RNF20 37
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 97 (a)
OneToMany
-- 37
  • 85 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf20 36
  • 69.32 (n)
  • 76.1 (a)
Str.444 36
zebrafish
(Danio rerio)
Actinopterygii Dr.6244 36
rnf20 36
  • 72.08 (n)
  • 77.31 (a)
rnf20 37
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Bre1 37
  • 41 (a)
OneToMany
CG10542 38
  • 46 (a)
worm
(Caenorhabditis elegans)
Secernentea rfp-1 37
  • 24 (a)
OneToMany
R05D3.4 38
  • 26 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BRE1 37
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10524 37
  • 40 (a)
OneToMany
Species with no ortholog for RNF20:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RNF20 Gene

ENSEMBL:
Gene Tree for RNF20 (if available)
TreeFam:
Gene Tree for RNF20 (if available)

Paralogs for RNF20 Gene

Paralogs for RNF20 Gene

Selected SIMAP similar genes for RNF20 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with RNF20: view

Variants for RNF20 Gene

Sequence variations from dbSNP and Humsavar for RNF20 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs728965 -- 101,563,399(+) TGATT(C/T)TATAT downstream-variant-500B
rs1885977 -- 101,545,593(-) TAGTA(A/T)ACAAA intron-variant
rs2273976 -- 101,547,163(-) GCTCC(A/G)TACAC synonymous-codon, reference
rs3818335 -- 101,533,567(-) ATAAA(C/G)TTCCT upstream-variant-2KB
rs3818336 -- 101,533,487(-) TCTCC(A/G)GGGAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RNF20 Gene

Variant ID Type Subtype PubMed ID
nsv893626 CNV Loss 21882294
nsv893627 CNV Loss 21882294
nsv831672 CNV Gain 17160897

Relevant External Links for RNF20 Gene

HapMap Linkage Disequilibrium report
RNF20
Human Gene Mutation Database (HGMD)
RNF20

Disorders for RNF20 Gene

No disorders were found for RNF20 Gene.

No data available for UniProtKB/Swiss-Prot for RNF20 Gene

Publications for RNF20 Gene

  1. The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression. (PMID: 18832071) Shema E. … Oren M. (Genes Dev. 2008) 2 3 23
  2. The human homolog of yeast BRE1 functions as a transcriptional coactivator through direct activator interactions. (PMID: 16337599) Kim J. … Roeder R.G. (Mol. Cell 2005) 2 3 4
  3. Human BRE1 is an E3 ubiquitin ligase for Ebp1 tumor suppressor. (PMID: 19037095) Liu Z. … Ye K. (Mol. Biol. Cell 2009) 2 3 4
  4. RAD6-mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cells. (PMID: 19410543) Kim J. … Roeder R.G. (Cell 2009) 3 4
  5. The Paf1 complex is essential for histone monoubiquitination by the Rad6-Bre1 complex, which signals for histone methylation by COMPASS and Dot1p. (PMID: 12876294) Wood A. … Shilatifard A. (J. Biol. Chem. 2003) 2 3

Products for RNF20 Gene

Sources for RNF20 Gene

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