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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RNF2 Gene

protein-coding   GIFtS: 60
GCID: GC01P185014

Ring Finger Protein 2

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ring Finger Protein 21 2 3     RING Finger Protein 1B2 3
BAP12 3 5     RING Finger Protein BAP-12 3
DING2 3 5     RING22 5
HIPI32 3 5     BAP-12
RING1B2 3 5     E3 Ubiquitin-Protein Ligase RING22
Huntingtin-Interacting Protein 2-Interacting Protein 32 3     EC 6.3.2.-3
Protein DinG2 3     RING1b3
HIP2-Interacting Protein 32 3     EC 6.3.28

External Ids:    HGNC: 100611   Entrez Gene: 60452   Ensembl: ENSG000001214817   OMIM: 6089855   UniProtKB: Q994963   

Export aliases for RNF2 gene to outside databases

Previous GC identifers: GC01P182540 GC01P180442 GC01P181534 GC01P182253 GC01P181746 GC01P183281 GC01P156249


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RNF2 Gene:
Polycomb group (PcG) of proteins form the multiprotein complexes that are important for the transcription
repression of various genes involved in development and cell proliferation. The protein encoded by this gene is
one of the PcG proteins. It has been shown to interact with, and suppress the activity of, transcription factor
CP2 (TFCP2/CP2). Studies of the mouse counterpart suggested the involvement of this gene in the specification of
anterior-posterior axis, as well as in cell proliferation in early development. This protein was also found to
interact with huntingtin interacting protein 2 (HIP2), an ubiquitin-conjugating enzyme, and possess ubiquitin
ligase activity. (provided by RefSeq, Jul 2008)

GeneCards Summary for RNF2 Gene: 
RNF2 (ring finger protein 2) is a protein-coding gene. Diseases associated with RNF2 include hemorrhoid, and embryonal cancer, and among its related super-pathways are DNA Damage and Signal transduction Activin A signaling regulation. GO annotations related to this gene include chromatin binding and RING-like zinc finger domain binding. An important paralog of this gene is RING1.

UniProtKB/Swiss-Prot: RING2_HUMAN, Q99496
Function: E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A, thereby
playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for
epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be
involved in the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group
(PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state
of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and
modification of histones, rendering chromatin heritably changed in its expressibility. E3 ubiquitin-protein
ligase activity is enhanced by BMI1/PCGF4. Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1
complex, while RING1 may rather act as a modulator of RNF2/RING2 activity

Gene Wiki entry for RNF2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RNF2 gene promoter:
         CREB   Sp1   deltaCREB   Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNF2 promoter sequence
   Search SABiosciences Chromatin IP Primers for RNF2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25.3   Ensembl cytogenetic band:  1q25.3   HGNC cytogenetic band: 1q25.3

RNF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P185014:  view genomic region     (about GC identifiers)

Start:
185,014,496 bp from pter      End:
185,071,740 bp from pter
Size:
57,245 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RING2_HUMAN, Q99496 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase RING2  
Size: 336 amino acids; 37655 Da
Subunit: Interacts with CBX2 and PHC1. Interacts with CHTOP (By similarity). Part of the E2F6.com-1 complex in G0
phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RNF1/RING1, RNF2/RING2, MBLR, L3MBTL2 and YAF2.
Component of a PRC1-like complex. Component of some MLL1/MLL complex, at least composed of the core components
KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70,
INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3,
TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with RYBP, HIP2 and TFCP2. Association to the chromosomal DNA
is cell-cycle dependent. Component of repressive BCOR complex containing Polycomb group subcomplex at least
composed of RYBP, PCGF1, BCOR and RING1. Component of chromatin-associated Polycomb (PcG) complexes. Interacts
with RYBP, PCGF2, CBX4, CBX6, CBX7 and CBX8. Interacts with RNF1/RING1, BMI1 and PHC2
Subcellular location: Nucleus. Chromosome (By similarity). Note=Enriched on inactive X chromosome (Xi) in female
trophoblast stem (TS) cells as well as differentiating embryonic stem (ES) cells. The enrichment on Xi is
transient during TS and ES cell differentiation. The association with Xi is mitotically stable in
non-differentiated TS cells (By similarity)
Miscellaneous: The hPRC-H complex purification reported by PubMed:12167701 probably presents a mixture of
different PRC1-like complexes
Sequence caution: Sequence=CAI17849.1; Type=Erroneous gene model prediction; Sequence=CAI17850.1; Type=Erroneous
gene model prediction;
5 PDB 3D structures from and Proteopedia for RNF2:
2H0D (3D)        3GS2 (3D)        3H8H (3D)        3IXS (3D)        3RPG (3D)    
Secondary accessions: B2RBS7 Q5TEN1 Q5TEN2

Explore the universe of human proteins at neXtProt for RNF2: NX_Q99496

Explore proteomics data for RNF2 at MOPED 

Post-translational modifications:

  • UniProtKB: Polyubiquitinated in the presence of UBE2D3 (in vitro) (By similarity)
  • UniProtKB: Monoubiquitinated, by auto-ubiquitination (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q99496

  • 4/13 DME Specific Peptides for RNF2 (Q99496) (see all 13)
     EIELVFR  WKVNKPME  HSNQEAGPS  SEKQYTIYI 

    RNF2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RNF2 Protein Expression
    REFSEQ proteins: NP_009143.1  
    ENSEMBL proteins: 
     ENSP00000356480   ENSP00000356479   ENSP00000400722  

    Human Recombinant Protein Products for RNF2: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RNF2 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex IDA16714294
    GO:0001739sex chromatin IEA--
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0016604nuclear body IEA--

    RNF2 for ontologies           About GeneDecksing



    RNF2 Antibody Products: 
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    Cloud-Clone Corp. ELISAs for RNF2 
    Cloud-Clone Corp. CLIAs for RNF2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RNF: RING-type (C3HC4) zinc fingers

    3 InterPro protein domains:
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q99496

    ProtoNet protein and cluster: Q99496

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: RING2_HUMAN, Q99496
    Similarity: Contains 1 RING-type zinc finger


    RNF2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RING2_HUMAN, Q99496
    Function: E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A, thereby
    playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for
    epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be
    involved in the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group
    (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state
    of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and
    modification of histones, rendering chromatin heritably changed in its expressibility. E3 ubiquitin-protein
    ligase activity is enhanced by BMI1/PCGF4. Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1
    complex, while RING1 may rather act as a modulator of RNF2/RING2 activity

         Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding IEA--
    GO:0004842contributes to ubiquitin-protein ligase activity IDA16714294
    GO:0005515protein binding IPI10369680
    GO:0008270zinc ion binding IDA16714294
    GO:0016874ligase activity ----
         
    RNF2 for ontologies           About GeneDecksing


    Phenotypes:
         12 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Rnf2):
     behavior/neurological  cellular  embryogenesis  growth/size  hematopoietic system 
     immune system  liver/biliary system  mortality/aging  nervous system  no phenotypic analysis 
     skeleton  tumorigenesis 

    RNF2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for RNF2: Rnf2tm1Mvl Rnf2tm1Hko

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RNF2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RNF2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RNF2 
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RNF2
    8/57 QIAGEN miScript miRNA Assays for microRNAs that regulate RNF2 (see all 57):
    hsa-miR-323-3p hsa-miR-607 hsa-miR-3607-3p hsa-miR-429 hsa-miR-300 hsa-miR-106a hsa-miR-301a hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmidRNF2 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RNF2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1DNA Damage
    Cell Cycle / Checkpoint Control0.32
    2Signal transduction Activin A signaling regulation
    Histone modification0.31
    3Chromatin Regulation / Acetylation
    Chromatin Regulation / Acetylation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for RNF2
        Histone modification


    2 Cell Signaling Technology (CST) Pathways for RNF2
        Chromatin Regulation / Acetylation
    Cell Cycle / Checkpoint Control


    UniProtKB/Swiss-Prot: RING2_HUMAN, Q99496
    Pathway: Protein modification; protein ubiquitination


    RNF2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RNF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/755 Interacting proteins for RNF2 (Q994961, 2, 3 ENSP000003564804) via UniProtKB, MINT, STRING, and/or I2D (see all 755)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000235107Q065871, 2, 3, ENSP000003964394EBI-722416,EBI-752313 MINT-7945693 MINT-8010325 MINT-8010390 I2D: score=5 STRING: ENSP00000396439
    ENSG00000206287Q065871, 2, 3EBI-722416,EBI-752313 MINT-7945693 MINT-8010325 MINT-8010390 I2D: score=5 
    ENSG00000226788Q065871, 2, 3EBI-722416,EBI-752313 MINT-7945693 MINT-8010325 MINT-8010390 I2D: score=5 
    ENSG00000228520Q065871, 2, 3EBI-722416,EBI-752313 MINT-7945693 MINT-8010325 MINT-8010390 I2D: score=5 
    ENSG00000231115Q065871, 2, 3EBI-722416,EBI-752313 MINT-7945693 MINT-8010325 MINT-8010390 I2D: score=5 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0000278mitotic cell cycle IEA--
    GO:0001702gastrulation with mouth forming second IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0009948anterior/posterior axis specification IEA--

    RNF2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RNF2 (RING2)

    4 HMDB Compounds for RNF2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    Search CenterWatch for drugs/clinical trials and news about RNF2 / RING2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RNF2 gene: 
    NM_007212.3  

    Unigene Cluster for RNF2:

    Ring finger protein 2
    Hs.591490  [show with all ESTs]
    Unigene Representative Sequence: NM_007212
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367510(uc001grc.1 uc001grd.1) ENST00000367509 ENST00000498201
    ENST00000453650
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    8/57 QIAGEN miScript miRNA Assays for microRNAs that regulate RNF2 (see all 57):
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    Additional mRNA sequence: 

    AF075026.1 AF141327.1 AK091574.1 AK314793.1 BC012583.1 Y10571.1 

    5 DOTS entries:

    DT.207496  DT.100775586  DT.40226134  DT.95271310  DT.91655531 

    24/97 AceView cDNA sequences (see all 97):

    BM128328 BI823097 BM984165 BP336107 AL542410 AU139548 BP337707 NM_007212 
    BM128548 D20143 BP341708 CR619047 BP351271 CA865739 CR597914 AI242656 
    BX338357 BX339055 BI518546 AU077049 AU135094 AL705397 BX386474 BE542786 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for RNF2 (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c
    SP1:                                      -     -                                                                     
    SP2:                                      -     -                 -     -     -                                       
    SP3:                                      -                                                                           
    SP4:                                      -     -                                                                     
    SP5:        -     -     -     -     -     -     -                                                                     


    ECgene alternative splicing isoforms for RNF2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RNF2 expression in normal human tissues (normalized intensities)      RNF2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    RNF2 Expression
    About this image


    RNF2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Gonad (Reproductive System)
             Primordial Germ Cells Primitive Gonad
     
     Brain (Nervous System)
             brain/midbrain   

    See RNF2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RNF2

    SOURCE GeneReport for Unigene cluster: Hs.591490
        SABiosciences Expression via Pathway-Focused PCR Arrays including RNF2: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              Polycomb & Trithorax Complexes in human mouse rat
              Epigenetic Chromatin Remodeling Factors in human mouse rat
              Ubiquitin Ligases in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RNF2 gene from 6/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnf21 , 5 ring finger protein 21, 5 92.16(n)1
    99.7(a)1
      1 (64.15 cM)5
    198211  NM_011277.21  NP_035407.11 
     1514694065 
    chicken
    (Gallus gallus)
    Aves RNF21 ring finger protein 2 84.42(n)
    97.92(a)
      424452  XM_422295.3  XP_422295.2 
    lizard
    (Anolis carolinensis)
    Reptilia RNF26
    Uncharacterized protein
    98(a)
    1 ↔ 1
    GL343203.1(3228926-3235741)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3985592 similar to ring finger protein 2 73.07(n)    BC046935.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rnf22 ring finger protein 2 74.37(n)   327035  BC044472.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ring3
    Sce1
    Sex combs extra1 80(a)3
    50.55(n)1
    52(a)1
      98B13
    433271  NM_058161.31  NP_477509.11 


    ENSEMBL Gene Tree for RNF2 (if available)
    TreeFam Gene Tree for RNF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RNF2 gene
    RING12  
    1 SIMAP similar gene for RNF2 using alignment to 2 protein entries:     RING2_HUMAN (see all proteins):
    RING1

    RNF2 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for RNF2
    PGOHUM00000249342 PGOHUM00000235958


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1085 SNPs in RNF2 are shown (see all 1085)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1475729401,2
    --185012618(+) CCATAA/GGTTTT 1 -- us2k10--------
    rs1845779471,2
    --185012718(+) ACTTTC/TCTCAA 1 -- us2k10--------
    rs1490355171,2
    --185012748(+) TCTAAC/TCACAC 1 -- us2k10--------
    rs1892004131,2
    --185012812(+) CCTGTC/TTTCCT 1 -- us2k10--------
    rs1430031261,2
    --185012892(+) GAAAGC/TGGACT 1 -- us2k10--------
    rs2001330761,2
    C--185012953(+) TTGTT-/TTGTT 
            
    TGTTT
    1 -- us2k10--------
    rs1512278931,2
    --185013247(+) CCACAC/TCCAGC 1 -- us2k10--------
    rs1403676581,2
    --185013317(+) ATAACC/TGTCAC 1 -- us2k10--------
    rs21446641,2
    C,F,A,H--185013349(+) AGTAGG/ACAAAA 1 -- us2k1 tfbs320Minor allele frequency- A:0.11EA NS NA WA 3916
    rs2003933721,2
    C--185013360(-) GGCTTG/TAAAGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RNF2 (185014496 - 185071740 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for RNF2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv525731CNV Gain19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608985    OMIM disorders: --

    13 diseases for RNF2:    About MalaCards
    hemorrhoid    embryonal cancer    hiv-1, resistance to    synovial sarcoma
    pancreatic ductal adenocarcinoma    acute leukemia    sarcoma    hodgkin's lymphoma
    mental retardation    adenocarcinoma    pancreatitis    endotheliitis
    leukemia


    RNF2 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for RNF2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hodgkin disease 26.9 1 15470680 (1)
    tumors 0 1 16528373 (1)

    Genetic Association Database (GAD): RNF2
    Human Genome Epidemiology (HuGE) Navigator: RNF2 (1 document)

    Export disorders for RNF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RNF2 gene, integrated from 9 sources (see all 108):
    (articles sorted by number of sources associating them with RNF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. E3 ligase activity of RING finger proteins that interact with Hip-2, a human ubiquitin-conjugating enzyme. (PubMed id 11513855)1, 2, 3, 9 Lee S.-J.... Kang S. (2001)
    2. Structure of a Bmi-1-Ring1B polycomb group ubiquitin ligase complex. (PubMed id 16714294)1, 2, 9 Li Z....Xu R.M. (2006)
    3. Interaction proteomics analysis of polycomb proteins defines distinct PRC1 Complexes in mammalian cells. (PubMed id 21282530)1, 2 Vandamme J.... Angrand P.O. (2011)
    4. Polycomb group targeting through different binding pa rtners of RING1B C-terminal domain. (PubMed id 20696397)1, 2 Wang R....Kim C.A. (2010)
    5. Several distinct polycomb complexes regulate and co-l ocalize on the INK4a tumor suppressor locus. (PubMed id 19636380)1, 2 Maertens G.N....Peters G. (2009)
    6. Novel susceptibility loci for second primary tumors/r ecurrence in head and neck cancer patients: large-scale evaluation of genetic v ariants. (PubMed id 19584075)1, 4 Wu X....Hong W.K. (2009)
    7. Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets. (PubMed id 16943429)1, 2 Gearhart M.D.... Bardwell V.J. (2006)
    8. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    9. Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. (PubMed id 16359901)1, 2 Cao R.... Zhang Y. (2005)
    10. Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. (PubMed id 15960975)1, 2 Dou Y.... Roeder R.G. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6045 HGNC: 10061 AceView: RNF2 Ensembl:ENSG00000121481 euGenes: HUgn6045
    ECgene: RNF2 H-InvDB: RNF2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RNF2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RNF2 gene:
    Search GeneIP for patents involving RNF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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