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RNF2 Gene

protein-coding   GIFtS: 62
GCID: GC01P185014

Ring Finger Protein 2

Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ring Finger Protein 21 2 3     RING Finger Protein 1B2 3
BAP12 3 5     RING Finger Protein BAP-12 3
DING2 3 5     RING22 5
HIPI32 3 5     BAP-12
RING1B2 3 5     E3 Ubiquitin-Protein Ligase RING22
Huntingtin-Interacting Protein 2-Interacting Protein 32 3     EC 6.3.2.-3
Protein DinG2 3     RING1b3
HIP2-Interacting Protein 32 3     EC 6.3.28

External Ids:    HGNC: 100611   Entrez Gene: 60452   Ensembl: ENSG000001214817   OMIM: 6089855   UniProtKB: Q994963   

Export aliases for RNF2 gene to outside databases

Previous GC identifers: GC01P182540 GC01P180442 GC01P181534 GC01P182253 GC01P181746 GC01P183281 GC01P156249


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RNF2 Gene:
Polycomb group (PcG) of proteins form the multiprotein complexes that are important for the transcription
repression of various genes involved in development and cell proliferation. The protein encoded by this gene is
one of the PcG proteins. It has been shown to interact with, and suppress the activity of, transcription factor
CP2 (TFCP2/CP2). Studies of the mouse counterpart suggested the involvement of this gene in the specification of
anterior-posterior axis, as well as in cell proliferation in early development. This protein was also found to
interact with huntingtin interacting protein 2 (HIP2), an ubiquitin-conjugating enzyme, and possess ubiquitin
ligase activity. (provided by RefSeq, Jul 2008)

GeneCards Summary for RNF2 Gene:
RNF2 (ring finger protein 2) is a protein-coding gene. Diseases associated with RNF2 include hemorrhoid, and embryonal cancer. GO annotations related to this gene include chromatin binding and RING-like zinc finger domain binding. An important paralog of this gene is RING1.

UniProtKB/Swiss-Prot: RING2_HUMAN, Q99496
Function: E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub),
thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic
transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in
the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG)
multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of
many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and
modification of histones, rendering chromatin heritably changed in its expressibility. E3 ubiquitin-protein
ligase activity is enhanced by BMI1/PCGF4. Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1
complex, while RING1 may rather act as a modulator of RNF2/RING2 activity. In resting B- and T-lymphocytes,
interaction with AURKB leads to block its activity, thereby maintaining transcription in resting lymphocytes

Gene Wiki entry for RNF2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RNF2 gene promoter:
         CREB   Sp1   deltaCREB   Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNF2 promoter sequence
   Search Chromatin IP Primers for RNF2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25.3   Ensembl cytogenetic band:  1q25.3   HGNC cytogenetic band: 1q25.3

RNF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P185014:  view genomic region     (about GC identifiers)

Start:
185,014,496 bp from pter      End:
185,071,740 bp from pter
Size:
57,245 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RING2_HUMAN, Q99496 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase RING2  
Size: 336 amino acids; 37655 Da
Subunit: Interacts with CBX2 and PHC1. Interacts with CHTOP. Interacts with AURKB (By similarity). Part of the
E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RNF1/RING1, RNF2/RING2,
MBLR, L3MBTL2 and YAF2. Component of a PRC1-like complex. Component of some MLL1/MLL complex, at least composed
of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components
BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2,
RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with RYBP, HIP2 and TFCP2.
Association to the chromosomal DNA is cell-cycle dependent. Component of repressive BCOR complex containing
Polycomb group subcomplex at least composed of RYBP, PCGF1, BCOR and RING1. Component of chromatin-associated
Polycomb (PcG) complexes. Interacts with RYBP, PCGF2, CBX4, CBX6, CBX7 and CBX8. Interacts with RNF1/RING1, BMI1
and PHC2
Miscellaneous: The hPRC-H complex purification reported by PubMed:12167701 probably presents a mixture of
different PRC1-like complexes
Sequence caution: Sequence=CAI17849.1; Type=Erroneous gene model prediction; Sequence=CAI17850.1; Type=Erroneous
gene model prediction;
5 PDB 3D structures from and Proteopedia for RNF2:
2H0D (3D)        3GS2 (3D)        3H8H (3D)        3IXS (3D)        3RPG (3D)    
Secondary accessions: B2RBS7 Q5TEN1 Q5TEN2

Explore the universe of human proteins at neXtProt for RNF2: NX_Q99496

Explore proteomics data for RNF2 at MOPED

Post-translational modifications: 

  • Polyubiquitinated in the presence of UBE2D3 (in vitro) (By similarity)1
  • Monoubiquitinated, by auto-ubiquitination (By similarity)1
  • Ubiquitination2 at Lys112, Lys149, Lys249, Lys261, Lys323
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for RNF2 (Q99496) (see all 13)
     EIELVFR  WKVNKPME  HSNQEAGPS  SEKQYTIYI 


    See RNF2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_009143.1  
    ENSEMBL proteins: 
     ENSP00000356480   ENSP00000356479   ENSP00000400722  
    Reactome Protein details: Q99496

    RNF2 Human Recombinant Protein Products:

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    Novus Biologicals RNF2 Proteins
    Novus Biologicals RNF2 Lysate
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    RNF2 Antibody Products:

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    Search for Antibodies for RNF2 at Abcam
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    ThermoFisher Antibodies for RNF2
    LSBio Antibodies in human, mouse, rat for RNF2

    RNF2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for RNF2
    Cloud-Clone Corp. CLIAs for RNF2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers

    4 InterPro protein domains:
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR018957 Znf_C3HC4_RING-type
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q99496

    ProtoNet protein and cluster: Q99496

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: RING2_HUMAN, Q99496
    Similarity: Contains 1 RING-type zinc finger


    RNF2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RING2_HUMAN, Q99496
    Function: E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub),
    thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic
    transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in
    the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG)
    multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of
    many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and
    modification of histones, rendering chromatin heritably changed in its expressibility. E3 ubiquitin-protein
    ligase activity is enhanced by BMI1/PCGF4. Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1
    complex, while RING1 may rather act as a modulator of RNF2/RING2 activity. In resting B- and T-lymphocytes,
    interaction with AURKB leads to block its activity, thereby maintaining transcription in resting lymphocytes

         Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding IEA--
    GO:0004842contributes to ubiquitin-protein ligase activity IDA16714294
    GO:0005515protein binding IPI10369680
    GO:0008270zinc ion binding IDA16714294
    GO:0016874ligase activity ----
         
    RNF2 for ontologies           About GeneDecksing


    Phenotypes:
         12 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Rnf2):
     behavior/neurological  cellular  embryogenesis  growth/size/body  hematopoietic system 
     immune system  liver/biliary system  mortality/aging  nervous system  no phenotypic analysis 
     skeleton  tumorigenesis 

    RNF2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for RNF2: Rnf2tm1Mvl Rnf2tm1Hko

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RNF2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RNF2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RNF2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RNF2

    miRNA
    Products:
        
    miRTarBase miRNAs that target RNF2:
    hsa-mir-155-5p (MIRT021040), hsa-mir-26b-5p (MIRT030193), hsa-mir-186-5p (MIRT021180), hsa-mir-92a-3p (MIRT049365), hsa-mir-24-3p (MIRT030624)

    Block miRNA regulation of human, mouse, rat RNF2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RNF2 (see all 57):
    hsa-miR-323-3p hsa-miR-607 hsa-miR-3607-3p hsa-miR-429 hsa-miR-300 hsa-miR-106a hsa-miR-301a hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmidRNF2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for RNF2
    Predesigned siRNA for gene silencing in human, mouse, rat RNF2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: RNF2 (NM_007212)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF2

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RING2_HUMAN, Q99496: Nucleus. Chromosome (By similarity). Note=Enriched on inactive X chromosome (Xi) in female
    trophoblast stem (TS) cells as well as differentiating embryonic stem (ES) cells. The enrichment on Xi is
    transient during TS and ES cell differentiation. The association with Xi is mitotically stable in
    non-differentiated TS cells (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex IDA16714294
    GO:0001739sex chromatin IEA--
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--

    RNF2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RNF2 About    
    See pathways by source

    SuperPathContained pathways About
    1Cellular Senescence
    Cellular Senescence0.81
    Oxidative Stress Induced Senescence0.64
    Cellular responses to stress0.81
    2Cell Cycle / Checkpoint Control
    Cell Cycle / Checkpoint Control0.32
    3Packaging Of Telomere Ends
    Histone modification0.31
    4Chromatin Regulation / Acetylation
    Chromatin Regulation / Acetylation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for RNF2
        Chromatin Regulation / Acetylation
    Cell Cycle / Checkpoint Control

    1 Reactome Pathway for RNF2
        Oxidative Stress Induced Senescence


    UniProtKB/Swiss-Prot: RING2_HUMAN, Q99496
    Pathway: Protein modification; protein ubiquitination


    RNF2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including RNF2: 

              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              Polycomb & Trithorax Complexes in human mouse rat
              Epigenetic Chromatin Remodeling Factors in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RNF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RNF2 (Q994961, 2, 3 ENSP000003564804) via UniProtKB, MINT, STRING, and/or I2D (see all 804)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000235107Q065871, 2, 3, ENSP000003964394EBI-722416,EBI-752313 MINT-7945693 MINT-8010325 MINT-8010390 I2D: score=5 STRING: ENSP00000396439
    ENSG00000206287Q065871, 2, 3EBI-722416,EBI-752313 MINT-7945693 MINT-8010325 MINT-8010390 I2D: score=5 
    ENSG00000226788Q065871, 2, 3EBI-722416,EBI-752313 MINT-7945693 MINT-8010325 MINT-8010390 I2D: score=5 
    ENSG00000228520Q065871, 2, 3EBI-722416,EBI-752313 MINT-7945693 MINT-8010325 MINT-8010390 I2D: score=5 
    ENSG00000231115Q065871, 2, 3EBI-722416,EBI-752313 MINT-7945693 MINT-8010325 MINT-8010390 I2D: score=5 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter ISS--
    GO:0000278mitotic cell cycle IEA--
    GO:0001702gastrulation with mouth forming second IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0009948anterior/posterior axis specification IEA--

    RNF2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RNF2 (RING2)

    4 HMDB Compounds for RNF2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RNF2 gene: 
    NM_007212.3  

    Unigene Cluster for RNF2:

    Ring finger protein 2
    Hs.591490  [show with all ESTs]
    Unigene Representative Sequence: NM_007212
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367510(uc001grc.1 uc001grd.1) ENST00000367509 ENST00000498201
    ENST00000453650
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Selected qRT-PCR Assays for microRNAs that regulate RNF2 (see all 57):
    hsa-miR-323-3p hsa-miR-607 hsa-miR-3607-3p hsa-miR-429 hsa-miR-300 hsa-miR-106a hsa-miR-301a hsa-miR-519a
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    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat RNF2

    Additional mRNA sequence: 

    AF075026.1 AF141327.1 AK091574.1 AK314793.1 BC012583.1 Y10571.1 

    5 DOTS entries:

    DT.207496  DT.100775586  DT.40226134  DT.95271310  DT.91655531 

    Selected AceView cDNA sequences (see all 97):

    AU139548 BM128328 AU135094 BX339055 AU077049 BP351271 BI823097 BX338357 
    BP336107 BI518546 BP337707 BM984165 NM_007212 BP341708 CA865739 AL542410 
    BM128548 CR597914 D20143 AI242656 CR619047 AI572147 BM676171 Y10571 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RNF2 (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c
    SP1:                                      -     -                                                                     
    SP2:                                      -     -                 -     -     -                                       
    SP3:                                      -                                                                           
    SP4:                                      -     -                                                                     
    SP5:        -     -     -     -     -     -     -                                                                     


    ECgene alternative splicing isoforms for RNF2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RNF2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    RNF2 Expression
    About this image


    RNF2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Gonad (Reproductive System)
             Primordial Germ Cells Primitive Gonad
     
     Neural Tube (Nervous System)
             Telencephalon
    RNF2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RNF2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591490
        Pathway & Disease-focused RT2 Profiler PCR Arrays including RNF2: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              Polycomb & Trithorax Complexes in human mouse rat
              Epigenetic Chromatin Remodeling Factors in human mouse rat
              Ubiquitin Ligases in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RNF2 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnf21 , 5 ring finger protein 21, 5 92.16(n)1
    99.7(a)1
      1 (64.15 cM)5
    198211  NM_011277.21  NP_035407.11 
     1514694065 
    chicken
    (Gallus gallus)
    Aves RNF21 ring finger protein 2 84.42(n)
    97.92(a)
      424452  XM_422295.4  XP_422295.2 
    lizard
    (Anolis carolinensis)
    Reptilia RNF26
    ring finger protein 2
    98(a)
    1 ↔ 1
    GL343203.1(3228926-3235741)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3985592 similar to ring finger protein 2 73.07(n)    BC046935.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rnf22 ring finger protein 2 74.37(n)   327035  BC044472.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ring3
    Sce1
    Sex combs extra1 80(a)3
    57.71(n)1
    62.9(a)1
      98B13
    433271  NM_058161.41  NP_477509.11 
    worm
    (Caenorhabditis elegans)
    Secernentea spat-36
    Protein SPAT-3, isoform a
    3(a)
    1 → many
    X(4595997-4605930) WBGene00020496


    ENSEMBL Gene Tree for RNF2 (if available)
    TreeFam Gene Tree for RNF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RNF2 gene
    RING12  
    1 SIMAP similar gene for RNF2 using alignment to 2 protein entries:     RING2_HUMAN (see all proteins):
    RING1

    RNF2 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for RNF2
    PGOHUM00000249342 PGOHUM00000235958


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RNF2 (see all 1085)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1475729401,2
    --185012618(+) CCATAA/GGTTTT 1 -- us2k10--------
    rs1845779471,2
    --185012718(+) ACTTTC/TCTCAA 1 -- us2k10--------
    rs1490355171,2
    --185012748(+) TCTAAC/TCACAC 1 -- us2k10--------
    rs1892004131,2
    --185012812(+) CCTGTC/TTTCCT 1 -- us2k10--------
    rs1430031261,2
    --185012892(+) GAAAGC/TGGACT 1 -- us2k10--------
    rs2001330761,2
    C--185012953(+) TTGTT-/TTGTT 
            
    TGTTT
    1 -- us2k10--------
    rs1512278931,2
    --185013247(+) CCACAC/TCCAGC 1 -- us2k10--------
    rs1403676581,2
    --185013317(+) ATAACC/TGTCAC 1 -- us2k10--------
    rs21446641,2
    C,F,A,H--185013349(+) AGTAGG/ACAAAA 1 -- us2k1 tfbs320Minor allele frequency- A:0.11EA NS NA WA 3916
    rs2003933721,2
    C--185013360(-) GGCTTG/TAAAGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RNF2 (185014496 - 185071740 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for RNF2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv525731CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RNF2
    DNA2.0 Custom Variant and Variant Library Synthesis for RNF2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608985    OMIM disorders: --

    16 diseases for RNF2:    
    About MalaCards
    hemorrhoid    embryonal cancer    hiv-1    synovial sarcoma
    pancreatic ductal adenocarcinoma    angelman syndrome    acute leukemia    mental retardation
    hodgkin's lymphoma    sarcoma    pancreatitis    adenocarcinoma
    obesity    leukemia    endotheliitis    malaria


    RNF2 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for RNF2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hodgkin disease 26.9 1 15470680 (1)
    tumors 0 1 16528373 (1)

    Genetic Association Database (GAD): RNF2
    Human Genome Epidemiology (HuGE) Navigator: RNF2 (1 document)

    Export disorders for RNF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RNF2 gene, integrated from 10 sources (see all 110):
    (articles sorted by number of sources associating them with RNF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. E3 ligase activity of RING finger proteins that interact with Hip-2, a human ubiquitin-conjugating enzyme. (PubMed id 11513855)1, 2, 3, 9 Lee S.-J.... Kang S. (FEBS Lett. 2001)
    2. Structure of a Bmi-1-Ring1B polycomb group ubiquitin ligase complex. (PubMed id 16714294)1, 2, 9 Li Z.... Xu R.M. (J. Biol. Chem. 2006)
    3. Interaction proteomics analysis of polycomb proteins defines distinct PRC1 Complexes in mammalian cells. (PubMed id 21282530)1, 2 Vandamme J.... Angrand P.O. (Mol. Cell. Proteomics 2011)
    4. Polycomb group targeting through different binding partners of RING1B C-terminal domain. (PubMed id 20696397)1, 2 Wang R.... Kim C.A. (Structure 2010)
    5. Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus. (PubMed id 19636380)1, 2 Maertens G.N.... Peters G. (PLoS ONE 2009)
    6. Novel susceptibility loci for second primary tumors/recurrence in head and neck cancer patients: large-scale evaluation of genetic variants. (PubMed id 19584075)1, 4 Wu X....Hong W.K. (Cancer Prev Res (Phila) 2009)
    7. Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets. (PubMed id 16943429)1, 2 Gearhart M.D.... Bardwell V.J. (Mol. Cell. Biol. 2006)
    8. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    9. Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. (PubMed id 16359901)1, 2 Cao R.... Zhang Y. (Mol. Cell 2005)
    10. Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. (PubMed id 15960975)1, 2 Dou Y.... Roeder R.G. (Cell 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6045 HGNC: 10061 AceView: RNF2 Ensembl:ENSG00000121481 euGenes: HUgn6045
    ECgene: RNF2 H-InvDB: RNF2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RNF2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RNF2 gene:
    Search GeneIP for patents involving RNF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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