RNF2 Gene
protein-coding GIFtS: 57
GCID: GC01P185014
|
|
ring finger protein 2
| |
Aliases
for RNF2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ring Finger Protein 21 2 3 | | Protein DinG2 3 | | BAP11 2 3 5 | | HIP2-Interacting Protein 32 3 | | DING1 2 3 5 | | RING Finger Protein 1B2 3 | | HIPI31 2 3 5 | | RING Finger Protein BAP-12 3 | | RING1B1 2 3 5 | | E3 Ubiquitin-Protein Ligase RING22 | | RING21 2 5 | | EC 6.3.2.-3 | | BAP-11 2 | | RING1b3 | | Huntingtin-Interacting Protein 2-Interacting Protein 32 3 | | EC 6.3.28 |
Export aliases for RNF2 gene to outside databasesPrevious GC identifers: GC01P182540 GC01P180442 GC01P181534 GC01P182253 GC01P181746 GC01P183281 GC01P156249 |
Summaries
for RNF2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RNF2:
Polycomb group (PcG) of proteins form the multiprotein complexes that are important for the transcription repression ofvarious genes involved in development and cell proliferation. The protein encoded by this gene is one of the PcGproteins. It has been shown to interact with, and suppress the activity of, transcription factor CP2 (TFCP2/CP2).Studies of the mouse counterpart suggested the involvement of this gene in the specification of anterior-posterioraxis, as well as in cell proliferation in early development. This protein was also found to interact with huntingtininteracting protein 2 (HIP2), an ubiquitin-conjugating enzyme, and possess ubiquitin ligase activity. (provided byRefSeq, Jul 2008)
UniProtKB/Swiss-Prot: RING2_HUMAN, Q99496Function: E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A, thereby playing acentral role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetictranscriptional repression and participates in X chromosome inactivation of female mammals. May be involved in theinitiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG) multiproteinPRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes,including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification ofhistones, rendering chromatin heritably changed in its expressibility. E3 ubiquitin-protein ligase activity isenhanced by BMI1/PCGF4. Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 mayrather act as a modulator of RNF2/RING2 activity
Gene Wiki entry for RNF2
|
Genomic Views
for RNF2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RNF2 gene promoter:
CREB Sp1 deltaCREB Nkx2-5
Other transcription factors
Search SABiosciences Chromatin IP Primers for RNF2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q25.3 Ensembl cytogenetic band: 1q25.3 HGNC cytogenetic band: 1q25.3RNF2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P185014: view genomic region
(about GC identifiers)
Start:
|
185,014,496 bp from pter |
End:
|
185,071,740 bp from pter |
Size:
|
57,245 bases |
Orientation:
|
plus strand |
|
Proteins
for RNF2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RING2_HUMAN, Q99496 (See
protein sequence)Recommended Name: E3 ubiquitin-protein ligase RING2 Size: 336 amino acids; 37655 Da
Subunit: Interacts with CBX2 and PHC1. Interacts with CHTOP (By similarity). Part of the E2F6.com-1 complex in G0 phasecomposed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RNF1/RING1, RNF2/RING2, MBLR, L3MBTL2 and YAF2. Component ofa PRC1-like complex. Component of some MLL1/MLL complex, at least composed of the core components MLL, ASH2L,HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L,MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7,TAF9 and TEX10. Interacts with RYBP, HIP2 and TFCP2. Association to the chromosomal DNA is cell-cycle dependent.Component of repressive BCOR complex containing Polycomb group subcomplex at least composed of RYBP, PCGF1, BCOR andRING1. Component of chromatin-associated Polycomb (PcG) complexes. Interacts with RYBP, PCGF2, CBX4, CBX6, CBX7 andCBX8. Interacts with RNF1/RING1, BMI1 and PHC2
Subcellular location: Nucleus. Chromosome (By similarity). Note=Enriched on inactive X chromosome (Xi) in femaletrophoblast stem (TS) cells as well as differentiating embryonic stem (ES) cells. The enrichment on Xi is transientduring TS and ES cell differentiation. The association with Xi is mitotically stable in non-differentiated TS cells(By similarity)
Miscellaneous: The hPRC-H complex purification reported by PubMed:12167701 probably presents a mixture of differentPRC1-like complexes
Sequence caution: Sequence=CAI17849.1; Type=Erroneous gene model prediction; Sequence=CAI17850.1; Type=Erroneous genemodel prediction;
5 PDB 3D structures from  and Proteopedia  for RNF2:2H0D (3D)
3GS2 (3D)
3H8H (3D)
3IXS (3D)
3RPG (3D)
Secondary accessions: B2RBS7 Q5TEN1 Q5TEN2Explore the universe of human proteins at neXtProt for RNF2: NX_Q99496
Post-translational modifications:
Polyubiquitinated in the presence of UBE2D3 (in vitro) (By similarity)1
Monoubiquitinated, by auto-ubiquitination (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q99496
4/13 DME Specific Peptides for RNF2 (Q99496) (see all 13)
RNF2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_009143.1
ENSEMBL proteins: ENSP00000356480 ENSP00000356479 ENSP00000400722
Human Recombinant Protein Products:
Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table
RNF2 for ontologies About GeneDecksing
RNF2 Antibody Products:
Assay Products for RNF2: |
Protein
Domains /
Families
for RNF2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RNF2 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q99496ProtoNet protein and cluster: Q99496 1 Blocks protein family: IPB001841 Zn-finger
UniProtKB/Swiss-Prot: RING2_HUMAN, Q99496Similarity: Contains 1 RING-type zinc finger |
Function
for RNF2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RING2_HUMAN, Q99496Function: E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A, thereby playing acentral role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetictranscriptional repression and participates in X chromosome inactivation of female mammals. May be involved in theinitiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG) multiproteinPRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes,including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification ofhistones, rendering chromatin heritably changed in its expressibility. E3 ubiquitin-protein ligase activity isenhanced by BMI1/PCGF4. Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 mayrather act as a modulator of RNF2/RING2 activityEnzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RNF2 (NM_007212) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RNF2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF2 |
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
RNF2 for ontologies About GeneDecksing
Animal Models:
Mouse knock-outs for RNF2: Rnf2tm1Mvl Rnf2tm1Hko
12 MGI mutant phenotypes (inferred from 6 alleles ) (MGI details for Rnf2):
RNF2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for RNF2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Chromatin Regulation / Acetylation | | | 2 | Cell Cycle / Checkpoint Control | | | 3 | Signal transduction Activin A signaling regulation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for RNF2
2 
Cell Signaling Technology (CST) Pathways for RNF2
UniProtKB/Swiss-Prot: RING2_HUMAN, Q99496Pathway: Protein modification; protein ubiquitination
RNF2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RNF2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/717 Interacting proteins for RNF2 (Q994961, 2, 3 ENSP000003564804) via UniProtKB, MINT, STRING, and/or I2D (see all 717)
| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| CBX8 | Q9HC521, 2, 3, ENSP000002693854 | EBI-722416,EBI-712912 MINT-8010325 MINT-8010390 MINT-4543689 I2D:
score=3 STRING: ENSP00000269385 | | PCGF2 | P352271, 2, 3, ENSP000003540334 | EBI-722416,EBI-2129767 MINT-8010390 I2D:
score=7 STRING: ENSP00000354033 | | CBX6 | O955031, 2, 3, ENSP000003844904 | EBI-722416,EBI-3951758 MINT-8010325 I2D:
score=1 STRING: ENSP00000384490 | | CBX4 | O002572, 3, ENSP000002693974 | MINT-8010325 MINT-8010390 I2D:
score=9 STRING: ENSP00000269397 | | PHC2 | Q8IXK02, 3, ENSP000002571184 | MINT-8010325 MINT-8010390 I2D:
score=3 STRING: ENSP00000257118 |
About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter |
IEA | -- | | GO:0000278 | mitotic cell cycle |
IEA | -- | | GO:0001702 | gastrulation with mouth forming second |
IEA | -- | | GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0009948 | anterior/posterior axis specification |
IEA | -- |
RNF2 for ontologies About GeneDecksing
|
Drugs & Compounds
for RNF2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RNF2
4 HMDB Compounds for RNF2 About this table
Search CenterWatch for drugs/clinical trials and news about RNF2 / RING2
|
Transcripts
for RNF2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RNF2 gene: NM_007212.3 Unigene Cluster for RNF2: Ring finger protein 2 Hs.591490 [show with all ESTs]Unigene Representative Sequence: NM_0072124 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000367510(uc001grc.1 uc001grd.1) ENST00000367509 ENST00000498201
ENST00000453650
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RNF2 (NM_007212) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RNF2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF2 |
Additional cDNA sequence: AF075026.1 AF141327.1 AK091574.1 AK314793.1 BC012583.1 Y10571.1 5 DOTS entries: DT.207496 DT.100775586 DT.40226134 DT.95271310 DT.91655531 24/97 AceView cDNA sequences (see all 97): BP341708 CR619047 NM_007212 BP351271 CR597914 CA865739 AI242656 BM128548 AU077049 BI518546 BX339055 AU135094 D20143 BM128328 BM984165 AL542410 BP336107 BP337707 AU139548 BX338357 BI823097 BX386474 AA843313 BP370261
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for RNF2 (see all 8) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | · | 11c |
|---|
|
| SP1: | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | - | | | | | | - | | - | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for RNF2
|
Expression
for RNF2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RNF2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See RNF2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RNF2
SOURCE GeneReport for Unigene cluster: Hs.591490
SABiosciences Expression via Pathway-Focused PCR Arrays including RNF2: | Ubiquitination (Ubiquitylation) Pathway in human mouse rat | | Epigenetic Chromatin Modification Enzymes in human mouse rat | | Polycomb & Trithorax Complexes in human mouse rat | | Epigenetic Chromatin Remodeling Factors in human mouse rat | | Ubiquitin Ligases in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNF2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RNF2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNF2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNF2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF2 |
Orthologs
for RNF2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for RNF2 gene from 7/25 species (see all 25) About this table
ENSEMBL Gene Tree for RNF2 (if available)
TreeFam Gene Tree for RNF2 (if available) |
Paralogs
for RNF2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RNF2 gene
- RING12
1 SIMAP similar gene for RNF2 using alignment to 2 protein entries: RING2_HUMAN (see all proteins):RING1
RNF2 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for RNF2
PGOHUM00000249342 PGOHUM00000235958
|
Genomic Variants
for RNF2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RNF2 (185014496 - 185071740 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RNF2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNF2 |
|
Disorders
/ Diseases
for RNF2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RNF2 for disorders About GeneDecksing
OMIM gene information: 608985
OMIM disorders: --
10  diseases for RNF2: About MalaCardshiv-1, resistance to x inactivation hemorrhoid pancreatic ductal adenocarcinoma
synovial sarcoma hodgkin's lymphoma sarcoma adenocarcinoma
pancreatitis leukemia
2 Novoseek disease relationships for RNF2 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| hodgkin disease |
26.9 |
1 |
15470680 (1) |
| tumors |
0 |
1 |
16528373 (1) |
Human Genome Epidemiology (HuGE) Navigator: RNF2 (1 document)
Export disorders for RNF2 gene to outside databases
|
Publications
for RNF2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RNF2 gene, integrated from 9 sources (see all 96):
(articles sorted by number of sources associating them with RNF2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- E3 ligase activity of RING finger proteins that interact with Hip-2, a human ubiquitin-conjugating enzyme. (PubMed id 11513855)1, 2, 3, 9 Lee S.-J.... Kang S. (2001)
- Structure of a Bmi-1-Ring1B polycomb group ubiquitin ligase complex. (PubMed id 16714294)1, 2, 9 Li Z....Xu R.M. (2006)
- Polycomb group targeting through different binding pa rtners of RING1B C-terminal domain. (PubMed id 20696397)1, 2 Wang R....Kim C.A. (2010)
- Several distinct polycomb complexes regulate and co-l ocalize on the INK4a tumor suppressor locus. (PubMed id 19636380)1, 2 Maertens G.N....Peters G. (2009)
- Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets. (PubMed id 16943429)1, 2 Gearhart M.D.... Bardwell V.J. (2006)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. (PubMed id 16359901)1, 2 Cao R.... Zhang Y. (2005)
- Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. (PubMed id 15960975)1, 2 Dou Y.... Roeder R.G. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Role of histone H2A ubiquitination in Polycomb silencing. (PubMed id 15386022)1, 2 Wang H.... Zhang Y. (2004)
|
External Searches for RNF2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RNF2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RNF2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RNF2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RNF2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RNF2 gene:
Search GeneIP for patents involving RNF2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RNF2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for RNF2 | | OriGene shRNA RFP for RNF2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RNF2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNF2 | | | OriGene Protein Over-expression Lysate for RNF2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RNF2 | | OriGene 3'-UTR Clone for RNF2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for RNF2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RNF2 | | OriGene Custom Protein Services for RNF2 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RNF2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNF2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNF2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNF2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNF2 |
| |
 |  |  |  | |
| | Antibodies & Assays for RNF2 |
| | | | Search Tocris compounds for RNF2 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | RNF2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF2 |
|  |  |  | | | | ThermoFisher Antibodies for RNF2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF2 |
|
|
|
|
