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RNF19B Gene

protein-coding   GIFtS: 52
GCID: GC01M033402

Ring Finger Protein 19B

(Previous name: IBR domain containing 3)
(Previous symbol: IBRDC3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ring Finger Protein 19B1 2 3     IBR Domain-Containing Protein 32 3
IBRDC31 2 3 5     E3 Ubiquitin-Protein Ligase RNF19B2
NKLAM2 3 5     EC 6.3.2.-3
IBR Domain Containing 31 2     EC 6.3.28
Natural Killer Lytic-Associated Molecule2 3     

External Ids:    HGNC: 268861   Entrez Gene: 1275442   Ensembl: ENSG000001165147   OMIM: 6108725   UniProtKB: Q6ZMZ03   

Export aliases for RNF19B gene to outside databases

Previous GC identifers: GC01M033175 GC01M031517


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RNF19B Gene:
IBRDC3 is a cytolysis-associated transmembrane protein expressed in natural killer (NK) cells and T lymphocytes
following cytokine stimulation (Kozlowski et al., 1999 (PubMed 10438909)).(supplied by OMIM, Mar 2008)

GeneCards Summary for RNF19B Gene:
RNF19B (ring finger protein 19B) is a protein-coding gene. Diseases associated with RNF19B include avian influenza, and influenza. GO annotations related to this gene include ligase activity. An important paralog of this gene is ANKIB1.

UniProtKB/Swiss-Prot: RN19B_HUMAN, Q6ZMZ0
Function: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and
UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as
UCKL1. Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RNF19B gene promoter:
         Nkx3-1   Nkx3-1 v4   AML1a   HNF-4alpha2   Nkx3-1 v1   Nkx2-5   Nkx3-1 v2   COMP1   Chx10   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNF19B promoter sequence
   Search Chromatin IP Primers for RNF19B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNF19B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p35.1   Ensembl cytogenetic band:  1p35.1   HGNC cytogenetic band: 1p35.1

RNF19B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF19B gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M033402:  view genomic region     (about GC identifiers)

Start:
33,402,046 bp from pter      End:
33,430,286 bp from pter
Size:
28,241 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RN19B_HUMAN, Q6ZMZ0 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase RNF19B  
Size: 732 amino acids; 77925 Da
Subunit: Interacts with UBE2L3, UBE2L6 and UCKL1
Sequence caution: Sequence=AAI13561.1; Type=Erroneous initiation; Sequence=CAI19336.1; Type=Erroneous initiation;
Sequence=EAX07490.1; Type=Erroneous initiation;
Secondary accessions: Q0VG77 Q5TH44 Q5TH45 Q6P6A4 Q8N2S8 Q8WUF3
Alternative splicing: 4 isoforms:  Q6ZMZ0-1   Q6ZMZ0-2   Q6ZMZ0-3   Q6ZMZ0-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RNF19B: NX_Q6ZMZ0

Explore proteomics data for RNF19B at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys338, Lys339
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for RNF19B (Q6ZMZ0) (see all 10)
     KYEEFMLRR  DDIKPCPRC  SKHKRNLAI  SLCRGGGCGV 


    See RNF19B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001120833.1  NP_699172.2  

    ENSEMBL proteins: 
     ENSP00000362555   ENSP00000349482   ENSP00000235150  
    Reactome Protein details: Q6ZMZ0

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers

    3 InterPro protein domains:
     IPR002867 Znf_C6HC
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q6ZMZ0

    ProtoNet protein and cluster: Q6ZMZ0

    1 Blocks protein domain: IPB002867 Zn-finger

    UniProtKB/Swiss-Prot: RN19B_HUMAN, Q6ZMZ0
    Domain: The first IBR-type zinc finger is the most crucial for interaction with UBE2L3, UBE2L6 and UCKL1
    Similarity: Belongs to the RBR family. RNF19 subfamily
    Similarity: Contains 1 IBR-type zinc finger
    Similarity: Contains 2 RING-type zinc fingers


    RNF19B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RN19B_HUMAN, Q6ZMZ0
    Function: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and
    UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as
    UCKL1. Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells
    Induction: In natural killer cells, by IFNB1/IFN-beta and IL2/interleukin-2 (at protein level)

         Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16709802
    GO:0008270zinc ion binding IEA--
    GO:0016874ligase activity IEA--
         
    RNF19B for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RNF19B:
     Increased cell number in G2M,  

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rnf19b):
     hematopoietic system  immune system  tumorigenesis 

    RNF19B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Rnf19btm1Jkorn for RNF19B

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RNF19B
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    miRNA
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    miRTarBase miRNAs that target RNF19B:
    hsa-mir-335-5p (MIRT018297)

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    5 qRT-PCR Assays for microRNAs that regulate RNF19B:
    hsa-miR-183* hsa-miR-589* hsa-miR-648 hsa-miR-218 hsa-miR-103a-2*
    SwitchGear 3'UTR luciferase reporter plasmidRNF19B 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RN19B_HUMAN, Q6ZMZ0: Cytoplasmic granule membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    plasma membrane3
    lysosome2
    nucleus2
    vacuole2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0016021integral component of membrane IEA--
    GO:0044194cytolytic granule IEA--

    RNF19B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RNF19B About    
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for RNF19B
        Antigen processing: Ubiquitination & Proteasome degradation


    UniProtKB/Swiss-Prot: RN19B_HUMAN, Q6ZMZ0
    Pathway: Protein modification; protein ubiquitination


    RNF19B for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including RNF19B: 

              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for RNF19B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for RNF19B (Q6ZMZ01, 3 ENSP000003625554) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE2L6O149331, 3, ENSP000002871564EBI-2466594,EBI-2129974 I2D: score=2 STRING: ENSP00000287156
    UBE2L3P680361, 3, ENSP000003442594EBI-2466594,EBI-711173 I2D: score=2 STRING: ENSP00000344259
    UCKL1Q9NWZ51, 3, ENSP000003461554EBI-2466594,EBI-2466660 I2D: score=1 STRING: ENSP00000346155
    BTG4Q9NY303, ENSP000003483004I2D: score=1 STRING: ENSP00000348300
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016567protein ubiquitination IEA--
    GO:0042267natural killer cell mediated cytotoxicity IEA--
    GO:0072643interferon-gamma secretion IEA--

    RNF19B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RNF19B (RN19B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RNF19B gene (2 alternative transcripts): 
    NM_001127361.1  NM_153341.2  

    Unigene Cluster for RNF19B:

    Ring finger protein 19B
    Hs.591504  [show with all ESTs]
    Unigene Representative Sequence: NM_001127361
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373456(uc010oho.2 uc010ohp.2) ENST00000356990(uc001bwm.4)
    ENST00000235150
    miRNA
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    5 qRT-PCR Assays for microRNAs that regulate RNF19B:
    hsa-miR-183* hsa-miR-589* hsa-miR-648 hsa-miR-218 hsa-miR-103a-2*
    SwitchGear 3'UTR luciferase reporter plasmidRNF19B 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat RNF19B

    Additional mRNA sequence: 

    AK074486.1 AK131439.1 BC020595.2 BC062374.1 BC113560.1 BC143687.1 

    4 DOTS entries:

    DT.87078211  DT.97778219  DT.121416726  DT.97768332 

    Selected AceView cDNA sequences (see all 91):

    BM782150 AA369389 AA808556 CD672310 BM720364 BM661996 AA459064 BC062374 
    BQ438077 AI761150 BM678705 BF849776 BM689928 BM846457 AA417244 BC020595 
    BX111998 BF982125 AW339584 AK131439 AA214177 AW964790 AW515706 AI217132 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for RNF19B    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c
    SP1:                                                                              
    SP2:                                                              -               
    SP3:                                                        -     -               


    ECgene alternative splicing isoforms for RNF19B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RNF19B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGTGTGTCA
    RNF19B Expression
    About this image


    RNF19B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Testis (Reproductive System)
    RNF19B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RNF19B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591504

    UniProtKB/Swiss-Prot: RN19B_HUMAN, Q6ZMZ0
    Tissue specificity: Expressed specifically in natural killer cells, activated macrophages and cytotoxic T-cells.
    Present in natural killer cells (at protein level)

        Pathway & Disease-focused RT2 Profiler PCR Array including RNF19B: 
              Ubiquitin Ligases in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF19B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RNF19B gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnf19b1 , 5 ring finger protein 19B1, 5 90.4(n)1
    93.07(a)1
      4 (62.76 cM)5
    752341  NM_029219.11  NP_083495.11 
     1290584095 
    chicken
    (Gallus gallus)
    Aves RNF19B1 ring finger protein 19B 79.77(n)
    88.16(a)
      419669  XM_417816.4  XP_417816.4 
    lizard
    (Anolis carolinensis)
    Reptilia RNF19B6
    ring finger protein 19B
    78(a)
    1 ↔ 1
    GL343711.1(17266-36784)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.23432 Transcribed sequence with moderate similarity to protein more 80.63(n)    AL896899.2 
    zebrafish
    (Danio rerio)
    Actinopterygii rnf19b1 ring finger protein 19B 67.13(n)
    70.58(a)
      562396  NM_001202440.1  NP_001189369.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y49F6B.96
    C17H11.66
    Protein C17H11.6, isoform a
    41(a)
    29(a)
    many ↔ many
    many ↔ many
    II(3493921-3499389) WBGene00021721
    X(8185194-8203784) WBGene00015926


    ENSEMBL Gene Tree for RNF19B (if available)
    TreeFam Gene Tree for RNF19B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RNF19B gene
    ANKIB12  ARIH12  ARIH22  RNF144A2  RNF144B2  RNF19A2  
    1 SIMAP similar gene for RNF19B using alignment to 4 protein entries:     RN19B_HUMAN (see all proteins):
    RNF19A

    RNF19B for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for RNF19B
    PGOHUM00000239049 PGOHUM00000241439 PGOHUM00000241440 PGOHUM00000233666 PGOHUM00000233667


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RNF19B (see all 665)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1465125631,2
    C--33401632(+) GGCGTA/GAGCCA 2 -- int10--------
    rs1410376831,2
    --33401642(+) ACCATA/GCCTGA 2 -- int10--------
    rs609915591,2
    F--33401749(+) GTTTTA/CAGAGT 2 -- int11Minor allele frequency- C:0.03EA 120
    rs1946371,2
    C,F,O,A,H--33401773(-) CCTCTA/GGAAGC 2 -- int119Minor allele frequency- G:0.20MN NS EA NA 2410
    rs1486690111,2
    C--33401790(+) AAGTT-/AAGTTT 2 -- int10--------
    rs1447942261,2
    --33401920(+) TACTGC/TGGTTG 2 -- int10--------
    rs80401,2
    C,F,A,H--33402172(+) TTAACC/TAATAA 2 -- ut31 ese324Minor allele frequency- T:0.19MN NA EA NS 4328
    rs1858783711,2
    --33402219(+) CTAACA/GGCAAA 2 -- ut310--------
    rs1903534801,2
    --33402255(+) ATTGTG/TAATTT 2 -- ut310--------
    rs1178077101,2
    F--33402323(+) AAATCT/CCTACC 2 -- ut311Minor allele frequency- C:0.02EA 120

    HapMap Linkage Disequilibrium report for RNF19B (33402046 - 33430286 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for RNF19B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2664245CNV Deletion23128226
    nsv509169CNV Insertion20534489
    nsv834602CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610872    OMIM disorders: --

    2 diseases for RNF19B:    
    About MalaCards
    avian influenza    influenza


    RNF19B for disorders           About GeneDecksing


    Export disorders for RNF19B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RNF19B gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with RNF19B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. NK lytic-associated molecule, involved in NK cytotoxic function, is an E3 ligase. (PubMed id 16709802)1, 2 Fortier J.M. and Kornbluth J. (J. Immunol. 2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    5. NK lytic-associated molecule: a novel gene selectively expressed in cells with cytolytic function. (PubMed id 10438909)1, 2 Kozlowski M.... Kornbluth J. (J. Immunol. 1999)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)
    8. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    9. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    10. Identification of the human testis protein phosphatase 1 interactome. (PubMed id 21382349)1 Fardilha M....da Cruz e Silva E.F. (Biochem. Pharmacol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 127544 HGNC: 26886 AceView: IBRDC3 Ensembl:ENSG00000116514 euGenes: HUgn127544
    ECgene: RNF19B H-InvDB: RNF19B

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RNF19B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for RNF19B gene:
    Search GeneIP for patents involving RNF19B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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