Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RNF19B Gene

Aliases for RNF19B Gene

  • Ring Finger Protein 19B 2 3
  • IBRDC3 3 4 6
  • NKLAM 3 4 6
  • Natural Killer Lytic-Associated Molecule 3 4
  • IBR Domain-Containing Protein 3 3 4
  • E3 Ubiquitin-Protein Ligase RNF19B 3
  • IBR Domain Containing 3 2
  • RING Finger Protein 19B 4
  • EC 6.3.2.- 4
  • EC 6.3.2 64

External Ids for RNF19B Gene

Previous Symbols for RNF19B Gene

  • IBRDC3

Summaries for RNF19B Gene

Entrez Gene Summary for RNF19B Gene

  • This gene encodes a multi-pass membrane protein containing two RING-type and one IBR-type zinc finger motifs. The encoded protin is an E3 ubiquitin-protein ligase that plays a role in the cytotoxic effects of natural killer (NK) cells. Alternative splicing results in multiple transcript variants. There are pseudogenes for this gene on chromosomes X and Y in a possible pseudoautosomal region. [provided by RefSeq, Jul 2014]

GeneCards Summary for RNF19B Gene

RNF19B (Ring Finger Protein 19B) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ligase activity. An important paralog of this gene is RNF19A.

UniProtKB/Swiss-Prot for RNF19B Gene

  • E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1. Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF19B Gene

Genomics for RNF19B Gene

Genomic Location for RNF19B Gene

Start:
32,933,864 bp from pter
End:
32,964,872 bp from pter
Size:
31,009 bases
Orientation:
Minus strand

Genomic View for RNF19B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNF19B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF19B Gene

Regulatory Elements for RNF19B Gene

Proteins for RNF19B Gene

  • Protein details for RNF19B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZMZ0-RN19B_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase RNF19B
    Protein Accession:
    Q6ZMZ0
    Secondary Accessions:
    • B7ZLB2
    • E9PAW6
    • G3XA82
    • Q0VG77
    • Q5TH44
    • Q5TH45
    • Q6P6A4
    • Q8N2S8
    • Q8WUF3

    Protein attributes for RNF19B Gene

    Size:
    732 amino acids
    Molecular mass:
    77925 Da
    Quaternary structure:
    • Interacts with UBE2L3, UBE2L6 and UCKL1.
    SequenceCaution:
    • Sequence=AAI13561.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI43688.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAX07490.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for RNF19B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNF19B Gene

Proteomics data for RNF19B Gene at MOPED

Post-translational modifications for RNF19B Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys338 and Lys339

Other Protein References for RNF19B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for RNF19B Gene

Gene Families for RNF19B Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for RNF19B Gene

UniProtKB/Swiss-Prot:

RN19B_HUMAN
Domain:
  • The first IBR-type zinc finger is the most crucial for interaction with UBE2L3, UBE2L6 and UCKL1:
    • Q6ZMZ0
Family:
  • Belongs to the RBR family. RNF19 subfamily.:
    • Q6ZMZ0
Similarity:
  • Contains 1 IBR-type zinc finger.:
    • Q6ZMZ0
  • Contains 2 RING-type zinc fingers.:
    • Q6ZMZ0
genes like me logo Genes that share domains with RNF19B: view

Function for RNF19B Gene

Molecular function for RNF19B Gene

UniProtKB/Swiss-Prot Function: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1. Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells.
UniProtKB/Swiss-Prot Induction: In natural killer cells, by IFNB1/IFN-beta and IL2/interleukin-2 (at protein level).

Enzyme Numbers (IUBMB) for RNF19B Gene

Gene Ontology (GO) - Molecular Function for RNF19B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16709802
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with RNF19B: view

Phenotypes for RNF19B Gene

MGI mutant phenotypes for RNF19B:
inferred from 1 alleles
GenomeRNAi human phenotypes for RNF19B:
genes like me logo Genes that share phenotypes with RNF19B: view

Animal Models for RNF19B Gene

MGI Knock Outs for RNF19B:

miRNA for RNF19B Gene

miRTarBase miRNAs that target RNF19B

No data available for Transcription Factor Targeting and HOMER Transcription for RNF19B Gene

Localization for RNF19B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF19B Gene

Cytoplasmic granule membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNF19B Gene COMPARTMENTS Subcellular localization image for RNF19B gene
Compartment Confidence
cytosol 3
plasma membrane 3
lysosome 2
nucleus 2
vacuole 2

Gene Ontology (GO) - Cellular Components for RNF19B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0016021 integral component of membrane IEA --
GO:0044194 cytolytic granule IEA --
genes like me logo Genes that share ontologies with RNF19B: view

Pathways for RNF19B Gene

genes like me logo Genes that share pathways with RNF19B: view

UniProtKB/Swiss-Prot Q6ZMZ0-RN19B_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for RNF19B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0042267 natural killer cell mediated cytotoxicity IEA --
GO:0072643 interferon-gamma secretion IEA --
genes like me logo Genes that share ontologies with RNF19B: view

Transcripts for RNF19B Gene

Unigene Clusters for RNF19B Gene

Ring finger protein 19B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNF19B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c
SP1:
SP2: -
SP3: - -

Relevant External Links for RNF19B Gene

GeneLoc Exon Structure for
RNF19B
ECgene alternative splicing isoforms for
RNF19B

Expression for RNF19B Gene

mRNA expression in normal human tissues for RNF19B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNF19B Gene

This gene is overexpressed in Whole Blood (5.1) and Testis (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RNF19B Gene

SOURCE GeneReport for Unigene cluster for RNF19B Gene Hs.591504

mRNA Expression by UniProt/SwissProt for RNF19B Gene

Q6ZMZ0-RN19B_HUMAN
Tissue specificity: Expressed specifically in natural killer cells, activated macrophages and cytotoxic T-cells. Present in natural killer cells (at protein level).
genes like me logo Genes that share expressions with RNF19B: view

Orthologs for RNF19B Gene

This gene was present in the common ancestor of animals.

Orthologs for RNF19B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNF19B 36
  • 99.57 (n)
  • 99.68 (a)
RNF19B 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RNF19B 36
  • 90.55 (n)
  • 92.3 (a)
RNF19B 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNF19B 36
  • 93.98 (n)
  • 96.7 (a)
RNF19B 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnf19b 36
  • 90.4 (n)
  • 93.07 (a)
Rnf19b 16
Rnf19b 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RNF19B 37
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RNF19B 37
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves RNF19B 36
  • 79.77 (n)
  • 88.16 (a)
RNF19B 37
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RNF19B 37
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf19b 36
  • 74.05 (n)
  • 81.91 (a)
Str.2343 36
zebrafish
(Danio rerio)
Actinopterygii rnf19b 36
  • 67.13 (n)
  • 70.58 (a)
rnf19b 37
  • 62 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C17H11.6 37
  • 29 (a)
ManyToMany
Y49F6B.9 37
  • 41 (a)
ManyToMany
Species with no ortholog for RNF19B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RNF19B Gene

ENSEMBL:
Gene Tree for RNF19B (if available)
TreeFam:
Gene Tree for RNF19B (if available)

Paralogs for RNF19B Gene

Paralogs for RNF19B Gene

Selected SIMAP similar genes for RNF19B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with RNF19B: view

Variants for RNF19B Gene

Sequence variations from dbSNP and Humsavar for RNF19B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs8040 -- 32,936,571(+) TTAAC(C/T)AATAA utr-variant-3-prime, intron-variant
rs168953 -- 32,951,027(-) ACCCT(A/G)TCTCT intron-variant
rs171837 -- 32,938,766(-) ggcag(A/G)agatg intron-variant
rs194637 -- 32,936,172(-) CCTCT(A/G)GAAGC downstream-variant-500B, intron-variant
rs194638 -- 32,936,495(+) TAATA(C/T)GTTTA utr-variant-3-prime, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNF19B Gene

Variant ID Type Subtype PubMed ID
nsv509169 CNV Insertion 20534489
nsv834602 CNV Loss 17160897
esv2664245 CNV Deletion 23128226

Relevant External Links for RNF19B Gene

HapMap Linkage Disequilibrium report
RNF19B

Disorders for RNF19B Gene

No disorders were found for RNF19B Gene.

No data available for UniProtKB/Swiss-Prot for RNF19B Gene

Publications for RNF19B Gene

  1. NK lytic-associated molecule, involved in NK cytotoxic function, is an E3 ligase. (PMID: 16709802) Fortier J.M. … Kornbluth J. (J. Immunol. 2006) 3 4
  2. NK lytic-associated molecule: a novel gene selectively expressed in cells with cytolytic function. (PMID: 10438909) Kozlowski M. … Kornbluth J. (J. Immunol. 1999) 3 4
  3. Gene structure of human and mouse NKLAM, a gene associated with cellular cytotoxicity. (PMID: 10912506) Portis T. … Kornbluth J. (Immunogenetics 2000) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for RNF19B Gene

Sources for RNF19B Gene

Back to Top

Content