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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RNF19A Gene

protein-coding   GIFtS: 58
GCID: GC08M101269

Ring Finger Protein 19A, RBR E3 Ubiquitin Protein Ligase

(Previous names: ring finger protein 19, ring finger protein 19A, ring finger...)
(Previous symbol: RNF19)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ring Finger Protein 19A, RBR E3 Ubiquitin Protein Ligase1     Protein P38 Interacting With Transcription Factor Sp12
RNF191 2 3     Ring-IBR-Ring Domain Containing Protein Dorfin2
Ring Finger Protein 19A, E3 Ubiquitin Protein Ligase1 2     Dorfin3
RING Finger Protein 19A1 3     EC 6.3.2.-3
Double Ring-Finger Protein2 3     p383
Ring Finger Protein 191     EC 6.3.28
E3 Ubiquitin-Protein Ligase RNF19A2     

External Ids:    HGNC: 134321   Entrez Gene: 258972   Ensembl: ENSG000000346777   OMIM: 6071195   UniProtKB: Q9NV583   

Export aliases for RNF19A gene to outside databases

Previous GC identifers: GC08M101340 GC08M096472


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RNF19A Gene:
This gene encodes a member of the ring between ring fingers (RBR) protein family, and the encoded protein contains
two RING-finger motifs and an in between RING fingers motif. This protein is an E3 ubiquitin ligase that is
localized to Lewy bodies, and ubiquitylates synphilin-1, which is an interacting protein of alpha synuclein in
neurons. The encoded protein may be involved in amyotrophic lateral sclerosis and Parkinson's disease.
Alternative splicing results in multiple transcript variants. (provided by RefSeq, Jul 2013)

GeneCards Summary for RNF19A Gene: 
RNF19A (ring finger protein 19A, RBR E3 ubiquitin protein ligase) is a protein-coding gene. Diseases associated with RNF19A include parkinson's disease, and multiple system atrophy, and among its related super-pathways are Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway. GO annotations related to this gene include transcription factor binding and ligase activity. An important paralog of this gene is RNF14.

UniProtKB/Swiss-Prot: RN19A_HUMAN, Q9NV58
Function: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and
UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as
SNCAIP or CASR. Specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation
and to neuronal protection

Gene Wiki entry for RNF19A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_008046.16  NC_018919.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RNF19A gene promoter:
         FOXF2   p53   POU3F1   ATF-2   POU6F1 (c2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNF19A promoter sequence
   Search SABiosciences Chromatin IP Primers for RNF19A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF19A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q22   Ensembl cytogenetic band:  8q22.2   HGNC cytogenetic band: 8q22

RNF19A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF19A gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M101269:  view genomic region     (about GC identifiers)

Start:
101,269,288 bp from pter      End:
101,348,446 bp from pter
Size:
79,159 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RN19A_HUMAN, Q9NV58 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase RNF19A  
Size: 838 amino acids; 90696 Da
Subunit: Interacts with UBE2L3 and UBE2L6. Interacts with transcription factor Sp1. Interacts with VCP, CASR,
SNCAIP and with some SOD1 variants which cause amyotrophic lateral sclerosis, but not with wild-type SOD1
Subcellular location: Membrane; Multi-pass membrane protein (Potential). Cytoplasm, cytoskeleton, microtubule
organizing center, centrosome. Note=Present in the hyaline inclusion bodies specifically found in motor neurons
from amyotrophic lateral sclerosis patients. Present in the Lewy bodies specifically found in neurons from
Parkinson disease patients
Sequence caution: Sequence=BAB14581.1; Type=Erroneous initiation; Sequence=BAB15647.1; Type=Erroneous initiation;
Secondary accessions: A3KCU9 Q52LG1 Q9H5H9 Q9H8M8 Q9UFG0 Q9UFX6 Q9Y4Y1
Alternative splicing: 3 isoforms:  Q9NV58-1   Q9NV58-2   Q9NV58-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RNF19A: NX_Q9NV58

Explore proteomics data for RNF19A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NV58

  • 4/10 DME Specific Peptides for RNF19A (Q9NV58) (see all 10)
     LMEKYEEF  KYEEFMLRR  DDIKPCPRC  SKHKRNLAI 

    RNF19A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RNF19A Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001267468.1  NP_056250.3  NP_904355.1  

    ENSEMBL proteins: 
     ENSP00000428968   ENSP00000342667   ENSP00000431077   ENSP00000429549   ENSP00000429841  
     ENSP00000429161   ENSP00000397305   ENSP00000430553  

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    Cloud-Clone Corp. Proteins for RNF19A 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005813centrosome TAS11237715
    GO:0016021integral to membrane IEA--

    RNF19A for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RNF: RING-type (C3HC4) zinc fingers

    3 InterPro protein domains:
     IPR002867 Znf_C6HC
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q9NV58

    ProtoNet protein and cluster: Q9NV58

    2 Blocks protein domains:
    IPB001841 Zn-finger
    IPB002867 Zn-finger


    UniProtKB/Swiss-Prot: RN19A_HUMAN, Q9NV58
    Similarity: Belongs to the RBR family. RNF19 subfamily
    Similarity: Contains 1 IBR-type zinc finger
    Similarity: Contains 2 RING-type zinc fingers


    RNF19A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RN19A_HUMAN, Q9NV58
    Function: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and
    UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as
    SNCAIP or CASR. Specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation
    and to neuronal protection

         Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008134transcription factor binding TAS10976766
    GO:0008270zinc ion binding NAS--
    GO:0016874ligase activity IEA--
         
    RNF19A for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for RNF19A:
     Increased G1 DNA content  Increased cell death HMECs cel 

         1 MGI phenotypic allele for Rnf19a (no phenotypes)

    RNF19A for phenotypes           About GeneDecksing

    Animal Models:
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RNF19A About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway0.93
    Parkin-Ubiquitin Proteasomal System pathway0.89

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for RNF19A
        Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway


    1 GeneGo (Thomson Reuters) Pathway for RNF19A
        Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway

    1 BioSystems Pathway for RNF19A
        Parkin-Ubiquitin Proteasomal System pathway


    UniProtKB/Swiss-Prot: RN19A_HUMAN, Q9NV58
    Pathway: Protein modification; protein ubiquitination


    RNF19A for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RNF19A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/20 Interacting proteins for RNF19A (Q9NV582, 3 ENSP000003426674) via UniProtKB, MINT, STRING, and/or I2D (see all 20)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP3K7O433182, 3, ENSP000003583354MINT-8259943 I2D: score=2 STRING: ENSP00000358335
    C11orf58O001932, 3MINT-8249851 I2D: score=2 
    ILKQ134182, 3MINT-8258610 I2D: score=2 
    NUDT21O438092, 3MINT-8264490 I2D: score=2 
    RPS6KA5O755822, 3MINT-8269670 I2D: score=2 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000226microtubule cytoskeleton organization TAS11237715
    GO:0006464cellular protein modification process NAS--
    GO:0016567protein ubiquitination IEA--

    RNF19A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RNF19A for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RNF19A (RN19A)

    2 Novoseek inferred chemical compound relationships for RNF19A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mg 132 74.3 4 11237715 (1), 16513638 (1), 18586549 (1)
    superoxide 8.66 4 15030390 (2), 15456787 (2)

    Search CenterWatch for drugs/clinical trials and news about RNF19A / RN19A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RNF19A gene (3 alternative transcripts): 
    NM_001280539.1  NM_015435.4  NM_183419.3  

    Unigene Cluster for RNF19A:

    Ring finger protein 19A, E3 ubiquitin protein ligase
    Hs.292882  [show with all ESTs]
    Unigene Representative Sequence: NM_183419
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000519449(uc003yjj.1 uc003yjl.1 uc003yjk.1) ENST00000341084
    ENST00000520903 ENST00000523255 ENST00000523644 ENST00000520071 ENST00000524233
    ENST00000519527 ENST00000523167 ENST00000522369 ENST00000517584 ENST00000432381
    ENST00000523481 ENST00000522182 ENST00000519342

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    Additional mRNA sequence: 

    AB029316.1 AB271913.1 AB271914.1 AJ242975.1 AK023455.1 AK027070.1 AL110253.1 AL122096.1 
    BC043648.1 BC062676.1 BC093938.1 BC093940.2 BC105300.1 

    22 DOTS entries:

    DT.116829  DT.100728731  DT.100848253  DT.97773514  DT.95287318  DT.432823  DT.100726364  DT.40243925 
    DT.100667507  DT.451683  DT.100783746  DT.121481083  DT.121481101  DT.121481107  DT.428625  DT.92445518 
    DT.92445520  DT.92445525  DT.92445541  DT.121481042  DT.95273645  DT.95287317 

    24/217 AceView cDNA sequences (see all 217):

    AU119452 AI767172 AI434418 BU076205 NM_015435 AL122096 AI245561 AA490535 
    AJ242975 CA419089 BI324835 BM557402 AA559115 BF507716 AI475137 AB029316 
    BQ003778 BI869381 BF198063 AA481787 CB044351 AW173096 AA767387 AA342293 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for RNF19A (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13
    SP1:                                                                                                                    -                       -               
    SP2:                                                                                                                    -           -           -               
    SP3:                    -     -     -                                                                                                                           
    SP4:                    -                                                                                                                                       
    SP5:                    -     -                                                                                                                                 


    ECgene alternative splicing isoforms for RNF19A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RNF19A expression in normal human tissues (normalized intensities)      RNF19A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCTGCAGTC
    RNF19A Expression
    About this image


    RNF19A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Gut Tube (Gastrointestinal Tract)
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
     
     Testis (Reproductive System)

    See RNF19A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RNF19A

    SOURCE GeneReport for Unigene cluster: Hs.292882

    UniProtKB/Swiss-Prot: RN19A_HUMAN, Q9NV58
    Tissue specificity: Widely expressed, with highest levels in heart. Ubiquitously expressed in the central nervous
    system

        SABiosciences Expression via Pathway-Focused PCR Array including RNF19A: 
              Ubiquitin Ligases in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RNF19A gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnf19a1 , 5 ring finger protein 19A1, 5 88.66(n)1
    93.79(a)1
      15 (14.46 cM)5
    309451  NM_013923.21  NP_038951.11 
     362399345 
    chicken
    (Gallus gallus)
    Aves RNF19A1 ring finger protein 19A 82.62(n)
    90.65(a)
      420251  XM_418362.3  XP_418362.3 
    lizard
    (Anolis carolinensis)
    Reptilia RNF19A6
    Uncharacterized protein
    87(a)
    1 ↔ 1
    GL343394.1(230587-249724)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.41212 Xenopus laevis transcribed sequence with strong similarity more 78.74(n)    BU909514.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5579951 e3 ubiquitin-protein ligase RNF19A-like 67.29(n)
    76.99(a)
      557995  XM_681158.5  XP_686250.4 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0045731 AGAP004573-PA 52.85(n)
    51.51(a)
      1274713  XM_313879.3  XP_313879.3 
    worm
    (Caenorhabditis elegans)
    Secernentea Y49F6B.96
    C17H11.66
    Protein C17H11.6, isoform a
    38(a)
    29(a)
    many ↔ many
    many ↔ many
    II(3493921-3499393)
    X(8185194-8203784)


    ENSEMBL Gene Tree for RNF19A (if available)
    TreeFam Gene Tree for RNF19A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RNF19A gene
    RNF142  RNF19B2  RNF144A2  RNF144B2  
    2 SIMAP similar genes for RNF19A using alignment to 8 protein entries:     RN19A_HUMAN (see all proteins):
    RNF19    RNF19B

    RNF19A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/994 SNPs in RNF19A are shown (see all 994)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1873939741,2
    --101268832(+) GAATAA/GAAAGC 2 -- ds5001 int10--------
    rs1485053081,2
    --101268897(+) TAGAAC/TAGAAT 2 -- ds5001 int10--------
    rs1922890511,2
    --101268913(+) AAAATA/GGTCTT 2 -- ds5001 int10--------
    rs1451701621,2
    C--101269046(+) CAACC-/AATTTA 2 -- ds5001 int10--------
    rs1834055881,2
    --101269079(+) ATACAA/GTATCT 2 -- ds5001 int10--------
    rs732827051,2
    C,F--101269199(+) ATCACA/GATGGC 2 -- ds5001 int12Minor allele frequency- G:0.09WA 120
    rs1892011171,2
    --101269230(+) ACCACA/GTGGCC 2 -- ds5001 int10--------
    rs2008054481,2
    --101269257(+) TTATT-/AAAAAA 2 -- ds5001 int10--------
    rs768757501,2
    F--101269258(+) TTATTA/TAAAAA 2 -- ds5001 int11Minor allele frequency- T:0.07WA 118
    rs1930647011,2
    --101269320(+) TTTAAC/TGTATG 2 -- ut310--------

    HapMap Linkage Disequilibrium report for RNF19A (101269288 - 101348446 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for RNF19A:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv820040CNV Loss19587683

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607119    OMIM disorders: --

    8 diseases for RNF19A:    About MalaCards
    parkinson's disease    multiple system atrophy    amyotrophic lateral sclerosis    lateral sclerosis
    neuronitis    dementia    prostate cancer    prostatitis

    1 disease from the University of Copenhagen DISEASES database for RNF19A:
    Amyotrophic lateral sclerosis

    RNF19A for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    3 Novoseek inferred disease relationships for RNF19A gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    amyotrophic lateral sclerosis 73.9 4 12875980 (1), 15030390 (1), 19610091 (1), 15456787 (1)
    parkinson disease 52.6 4 12413654 (2), 12875980 (1), 15456787 (1)
    neurodegenerative diseases 51.6 5 15456787 (3), 14635514 (1), 12875980 (1)

    Genetic Association Database (GAD): RNF19A

    Export disorders for RNF19A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RNF19A gene, integrated from 9 sources (see all 38):
    (articles sorted by number of sources associating them with RNF19A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel centrosomal ring-finger protein, dorfin, mediates ubiquitin ligase activity. (PubMed id 11237715)1, 2, 3, 9 Niwa J.... Sobue G. (2001)
    2. A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening. (PubMed id 10976766)1, 2, 3 Gunther M....Brison O. (2000)
    3. Physical and functional interaction between dorfin and valosin- containing protein that are colocalized in ubiquitylated inclusions in neurodegenerative disorders. (PubMed id 15456787)1, 2, 9 Ishigaki S.... Sobue G. (2004)
    4. Dorfin localizes to Lewy bodies and ubiquitylates synphilin-1. (PubMed id 12750386)1, 2, 9 Ito T.... Sobue G. (2003)
    5. Dorfin ubiquitylates mutant SOD1 and prevents mutant SOD1-mediated neurotoxicity. (PubMed id 12145308)1, 2, 9 Niwa J.... Sobue G. (2002)
    6. Calcium-sensing receptor ubiquitination and degradation mediated by the E3 ubiquitin ligase dorfin. (PubMed id 16513638)1, 2, 9 Huang Y.... Breitwieser G.E. (2006)
    7. Identification of genomic predictors of atrioventricu lar conduction: using electronic medical records as a tool for genome science. (PubMed id 21041692)1, 4 Denny J.C....Roden D.M. (2010)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Dorfin localizes to the ubiquitylated inclusions in Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, and amyotrophic lateral sclerosis. (PubMed id 12875980)1, 9 Hishikawa N....Sobue G. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 25897 HGNC: 13432 AceView: RNF19 Ensembl:ENSG00000034677 euGenes: HUgn25897
    ECgene: RNF19A H-InvDB: RNF19A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RNF19A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RNF19A gene:
    Search GeneIP for patents involving RNF19A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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