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Aliases for RNF187 Gene

Aliases for RNF187 Gene

  • Ring Finger Protein 187 2 3
  • RING Domain AP1 Coactivator 1 3 4
  • RING Finger Protein 187 4 5
  • RACO-1 3 4
  • Protein RNF187 3
  • EC 6.3.2.- 4
  • RACO1 3

External Ids for RNF187 Gene

Previous GeneCards Identifiers for RNF187 Gene

  • GC01P224982
  • GC01P226740
  • GC01P228675
  • GC01P199189

Summaries for RNF187 Gene

GeneCards Summary for RNF187 Gene

RNF187 (Ring Finger Protein 187) is a Protein Coding gene. GO annotations related to this gene include ligase activity and ubiquitin-protein transferase activity.

UniProtKB/Swiss-Prot for RNF187 Gene

  • E3 ubiquitin-protein ligase that acts as a coactivator of JUN-mediated gene activation in response to growth factor signaling via the MAP3K1 pathway, independently from MAPK8.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF187 Gene

Genomics for RNF187 Gene

Regulatory Elements for RNF187 Gene

Promoters for RNF187 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RNF187 on UCSC Golden Path with GeneCards custom track

Genomic Location for RNF187 Gene

Chromosome:
1
Start:
228,487,061 bp from pter
End:
228,496,188 bp from pter
Size:
9,128 bases
Orientation:
Plus strand

Genomic View for RNF187 Gene

Genes around RNF187 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF187 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF187 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF187 Gene

Proteins for RNF187 Gene

  • Protein details for RNF187 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TA31-RN187_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase RNF187
    Protein Accession:
    Q5TA31
    Secondary Accessions:
    • A6NL57
    • Q6P2J7
    • Q6PJR0

    Protein attributes for RNF187 Gene

    Size:
    235 amino acids
    Molecular mass:
    26190 Da
    Quaternary structure:
    • Homodimer. Interacts with JUN, independently of JUN phosphorylation.
    SequenceCaution:
    • Sequence=AAH12758.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH12758.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence={ECO:0000305}; Sequence=CAI23328.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for RNF187 Gene

Proteomics data for RNF187 Gene at MOPED

Post-translational modifications for RNF187 Gene

  • Arginine methylation by PRMT1 stabilizes RNF187 by facilitating K63-linked ubiquitin chain formation, and enables dimerization, c-Jun interaction and subsequent AP1 target gene expression.
  • Ubiquitinated; undergoes Lys-48-linked autoubiquitination in the absence of growth factors and MAP3K1-induced Lys-63-linked polyubiquitination. Lys-48-autoubiquitination leads to degradation by the proteasome, while MAP3K1-induced Lys-63-linked polyubiquitination results in the stabilization of the protein. Lys-48- and Lys-63-linked polyubiquitinations occur most probably on the same 3 C-terminal lysine residues (Lys-195, Lys-223 and Lys-224) and are thus mutually exclusive. Other sites of ubiquitination are not excluded.
  • Ubiquitination at Lys 161, Lys 195, Lys 223, and Lys 224
  • Modification sites at PhosphoSitePlus

Other Protein References for RNF187 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RNF187 Gene

Domains & Families for RNF187 Gene

Gene Families for RNF187 Gene

Protein Domains for RNF187 Gene

Suggested Antigen Peptide Sequences for RNF187 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5TA31

UniProtKB/Swiss-Prot:

RN187_HUMAN :
  • The RING-type zinc finger domain is required for E3 ligase activity.
  • Contains 1 RING-type zinc finger.
Domain:
  • The RING-type zinc finger domain is required for E3 ligase activity.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF187: view

Function for RNF187 Gene

Molecular function for RNF187 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase that acts as a coactivator of JUN-mediated gene activation in response to growth factor signaling via the MAP3K1 pathway, independently from MAPK8.

Enzyme Numbers (IUBMB) for RNF187 Gene

Gene Ontology (GO) - Molecular Function for RNF187 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 20852630
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with RNF187: view

Phenotypes for RNF187 Gene

GenomeRNAi human phenotypes for RNF187:
genes like me logo Genes that share phenotypes with RNF187: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNF187 Gene

Localization for RNF187 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF187 Gene

Cytoplasm. Nucleus. Note=Predominantly located in the cytoplasm. Shuttles between the cytoplasm and the nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNF187 Gene COMPARTMENTS Subcellular localization image for RNF187 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for RNF187 Gene

Pathways & Interactions for RNF187 Gene

SuperPathways for RNF187 Gene

No Data Available

UniProtKB/Swiss-Prot Q5TA31-RN187_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for RNF187 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IMP 20852630
GO:0045893 positive regulation of transcription, DNA-templated IMP 20852630
genes like me logo Genes that share ontologies with RNF187: view

No data available for Pathways by source and SIGNOR curated interactions for RNF187 Gene

Drugs & Compounds for RNF187 Gene

No Compound Related Data Available

Transcripts for RNF187 Gene

mRNA/cDNA for RNF187 Gene

Unigene Clusters for RNF187 Gene

Ring finger protein 187:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNF187 Gene

No ASD Table

Relevant External Links for RNF187 Gene

GeneLoc Exon Structure for
RNF187
ECgene alternative splicing isoforms for
RNF187

Expression for RNF187 Gene

mRNA expression in normal human tissues for RNF187 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RNF187 Gene

This gene is overexpressed in Adrenal (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RNF187 Gene



SOURCE GeneReport for Unigene cluster for RNF187 Gene Hs.356377

genes like me logo Genes that share expression patterns with RNF187: view

Protein tissue co-expression partners for RNF187 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RNF187 Gene

Orthologs for RNF187 Gene

This gene was present in the common ancestor of mammals.

Orthologs for RNF187 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RNF187 35
  • 87.09 (n)
  • 92.77 (a)
RNF187 36
  • 49 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnf187 35
  • 88.79 (n)
  • 95.32 (a)
Rnf187 16
Rnf187 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RNF187 35
  • 92.34 (n)
  • 91.06 (a)
RNF187 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnf187 35
  • 87.09 (n)
  • 95.32 (a)
Species with no ortholog for RNF187:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RNF187 Gene

ENSEMBL:
Gene Tree for RNF187 (if available)
TreeFam:
Gene Tree for RNF187 (if available)

Paralogs for RNF187 Gene

(2) SIMAP similar genes for RNF187 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RNF187: view

No data available for Paralogs for RNF187 Gene

Variants for RNF187 Gene

Sequence variations from dbSNP and Humsavar for RNF187 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2495 -- 228,496,064(-) TAAAC(G/T)CAAGG utr-variant-3-prime
rs12542 -- 228,494,629(-) GACAC(C/G)ATGGC utr-variant-3-prime
rs15539 -- 228,488,992(+) AGAAA(G/T)GACTT reference, missense
rs1139333 -- 228,496,073(+) TATTC(C/T)TGTAT utr-variant-3-prime
rs1046390 -- 228,494,769(+) TCAGC(A/C)CTGGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RNF187 Gene

Variant ID Type Subtype PubMed ID
esv32853 CNV Gain 17666407
nsv826908 CNV Gain 20364138
nsv523935 CNV Loss 19592680
nsv873255 CNV Loss 21882294
nsv873270 CNV Loss 21882294
nsv517545 CNV Loss 19592680
dgv542n71 CNV Loss 21882294
nsv468305 CNV Gain 19166990

Variation tolerance for RNF187 Gene

Gene Damage Index Score: 0.22; 4.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNF187 Gene

HapMap Linkage Disequilibrium report
RNF187

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF187 Gene

Disorders for RNF187 Gene

Relevant External Links for RNF187

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RNF187

No disorders were found for RNF187 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF187 Gene

Publications for RNF187 Gene

  1. Arginine methylation of the c-Jun coactivator RACO-1 is required for c-Jun/AP-1 activation. (PMID: 23624934) Davies C.C. … Behrens A. (EMBO J. 2013) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Genome-wide association study of ancestry-specific TB risk in the South African Coloured population. (PMID: 24057671) Chimusa E.R. … Hoal E.G. (Hum. Mol. Genet. 2014) 3
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3

Products for RNF187 Gene

Sources for RNF187 Gene

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