Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



RNF187 Gene

protein-coding   GIFtS: 43
GCID: GC01P228675

Ring Finger Protein 187

  Search for RNF187
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Ring Finger Protein 1871 2 3     E3 Ubiquitin-Protein Ligase RNF1872
RACO-12 3     Protein RNF1872
RING Domain AP1 Coactivator 12 3     EC 6.3.2.-3
RACO12 5     RNF1865

External Ids:    HGNC: 271461   Entrez Gene: 1496032   Ensembl: ENSG000001681597   OMIM: 6137545   UniProtKB: Q5TA313   

Export aliases for RNF187 gene to outside databases

Previous GC identifers: GC01P224982 GC01P226740 GC01P199189


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for RNF187 Gene:
RNF187 (ring finger protein 187) is a protein-coding gene. GO annotations related to this gene include ubiquitin-protein ligase activity.

UniProtKB/Swiss-Prot: RN187_HUMAN, Q5TA31
Function: E3 ubiquitin-protein ligase that acts as a coactivator of JUN-mediated gene activation in response to
growth factor signaling via the MAP3K1 pathway, independently from MAPK8




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_167186.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RNF187 gene promoter:
         GATA-3   Pax-5   Nkx2-2   MIF-1   Egr-4   YY1   Egr-2   FOXO4   ZID   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RNF187 promoter sequence
   Search Chromatin IP Primers for RNF187

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNF187


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42.13   Ensembl cytogenetic band:  1q42.13   HGNC cytogenetic band: 1q42.13

RNF187 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF187 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P228675:  view genomic region     (about GC identifiers)

Start:
228,674,762 bp from pter      End:
228,683,889 bp from pter
Size:
9,128 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: RN187_HUMAN, Q5TA31 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase RNF187  
Size: 235 amino acids; 26190 Da
Subunit: Homodimer. Interacts with JUN, independently of JUN phosphorylation
Caution: This sequence initiates at a CTG codon (PubMed:20852630)
Sequence caution: Sequence=AAH12758.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=AAH12758.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by
a non-canonical CTG leucine codon; Sequence=CAI23328.1; Type=Erroneous gene model prediction;
Secondary accessions: A6NL57 Q6P2J7 Q6PJR0

Explore the universe of human proteins at neXtProt for RNF187: NX_Q5TA31

Explore proteomics data for RNF187 at MOPED

Post-translational modifications: 

  • Ubiquitinated; undergoes 'Lys-48'-linked autoubiquitination in the absence of growth factors and MAP3K1-induced
    'Lys-63'-linked polyubiquitination. 'Lys-48'-autoubiquitination leads to degradation by the proteasome, while
    MAP3K1-induced 'Lys-63'-linked polyubiquitination results in the stabilization of the protein. 'Lys-48'- and
    'Lys-63'-linked polyubiquitinations occur most probably on the same 3 C-terminal lysine residues (Lys-195,
    Lys-223 and Lys-224) and are thus mutually exclusive. Other sites of ubiquitination are not excluded1
  • Arginine methylation by PRMT1 stabilizes RNF187 by facilitating K63-linked ubiquitin chain formation, and enables
    dimerization, c-Jun interaction and subsequent AP1 target gene expression1
  • Ubiquitination2 at Lys161, Lys195, Lys223, Lys224
  • Modification sites at PhosphoSitePlus

  • See RNF187 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001010858.2  
    ENSEMBL proteins: 
     ENSP00000306396  

    RNF187 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for RNF187
    GenScript Custom Purified and Recombinant Proteins Services for RNF187
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RNF187

    RNF187 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for RNF187
    Novus Biologicals RNF187 Antibody
    Search for Antibodies for RNF187 at Abcam
    Cloud-Clone Corp. Antibodies for RNF187
    Search ThermoFisher Antibodies for RNF187
    LSBio Antibodies in human, mouse, rat for RNF187

    RNF187 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RNF187
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RNF187
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RNF187
    Cloud-Clone Corp. CLIAs for RNF187


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers

    4 InterPro protein domains:
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR018957 Znf_C3HC4_RING-type
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q5TA31

    ProtoNet protein and cluster: Q5TA31

    UniProtKB/Swiss-Prot: RN187_HUMAN, Q5TA31
    Domain: The RING-type zinc finger domain is required for E3 ligase activity
    Similarity: Contains 1 RING-type zinc finger


    RNF187 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RN187_HUMAN, Q5TA31
    Function: E3 ubiquitin-protein ligase that acts as a coactivator of JUN-mediated gene activation in response to
    growth factor signaling via the MAP3K1 pathway, independently from MAPK8

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IDA--
    GO:0005515protein binding IPI--
    GO:0008270zinc ion binding IEA--
         
    RNF187 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RNF187
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RNF187

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RNF187
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RNF187

    miRNA
    Products:
        
    miRTarBase miRNAs that target RNF187:
    hsa-mir-99a-5p (MIRT048702), hsa-mir-18a-3p (MIRT040880), hsa-mir-181b-5p (MIRT047251), hsa-mir-26b-5p (MIRT029670)

    Block miRNA regulation of human, mouse, rat RNF187 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate RNF187
    SwitchGear 3'UTR luciferase reporter plasmidRNF187 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RNF187
    Predesigned siRNA for gene silencing in human, mouse, rat RNF187

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RNF187

    Clone
    Products:
         
    OriGene clones in human, mouse for RNF187 (see all 10)
    OriGene ORF clones in mouse, rat for RNF187
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RNF187 (NM_001010858)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNF187
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat RNF187

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RNF187
    Browse ESI BIO Cell Lines and PureStem Progenitors for RNF187 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF187


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    RN187_HUMAN, Q5TA31: Cytoplasm. Nucleus. Note=Predominantly located in the cytoplasm. Shuttles between the
    cytoplasm and the nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    extracellular1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    RNF187 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



    UniProtKB/Swiss-Prot: RN187_HUMAN, Q5TA31
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Array including RNF187: 

              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for RNF187

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for RNF187 (Q5TA313 ENSP000003063964) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    JUNP054123, ENSP000003602664I2D: score=2 STRING: ENSP00000360266
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008284positive regulation of cell proliferation ISS--
    GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process IMP--
    GO:0045893positive regulation of transcription, DNA-templated IMP--
    GO:0051865protein autoubiquitination IDA--
    GO:0070936protein K48-linked ubiquitination IMP--

    RNF187 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RNF187 (RN187)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for RNF187 gene: 
    NM_001010858.2  

    Unigene Cluster for RNF187:

    Ring finger protein 187
    Hs.356377  [show with all ESTs]
    Unigene Representative Sequence: NM_001010858
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000305943(uc001htb.3) ENST00000482739 ENST00000484293 ENST00000493597

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RNF187 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate RNF187
    SwitchGear 3'UTR luciferase reporter plasmidRNF187 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RNF187
    Predesigned siRNA for gene silencing in human, mouse, rat RNF187
    Clone
    Products:
         
    OriGene clones in human, mouse for RNF187 (see all 10)
    OriGene ORF clones in mouse, rat for RNF187
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RNF187 (NM_001010858)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNF187
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat RNF187
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for RNF187
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RNF187
      QuantiTect SYBR Green Assays in human, mouse, rat RNF187
      QuantiFast Probe-based Assays in human, mouse, rat RNF187

    Additional mRNA sequence: 

    BC000821.1 BC008022.1 BC012758.2 BC053571.1 BC064481.1 BC080645.1 

    12 DOTS entries:

    DT.449720  DT.100818379  DT.121446839  DT.409159  DT.75140503  DT.102834808  DT.102834807  DT.121446830 
    DT.95301212  DT.121446838  DT.91833630  DT.99992488 

    Selected AceView cDNA sequences (see all 411):

    BQ670352 AA677549 AI183434 AA806184 BQ643621 AW160369 F18378 BF446314 
    BF222390 CD101702 T08545 AW070716 AW194994 AI201026 AI734200 BM698423 
    BX956940 BQ650611 CR599642 BQ188202 T75538 AI085556 AA594261 BE465794 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    RNF187 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGTCTCATC
    RNF187 Expression
    About this image


    RNF187 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
     
     Thyroid (Endocrine System)
    RNF187 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RNF187 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.356377
        Pathway & Disease-focused RT2 Profiler PCR Array including RNF187: 
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for RNF187
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RNF187
    QuantiTect SYBR Green Assays in human, mouse, rat RNF187
    QuantiFast Probe-based Assays in human, mouse, rat RNF187
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF187

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of human and mouse.

    Orthologs for RNF187 gene from Selected species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnf1871 , 5 ring finger protein 1871, 5 88.79(n)1
    95.32(a)1
      11 (36.37 cM)5
    1086601  NM_022423.21  NP_071868.21 
     589322885 


    ENSEMBL Gene Tree for RNF187 (if available)
    TreeFam Gene Tree for RNF187 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for RNF187 gene
    2 SIMAP similar genes for RNF187 using alignment to 2 protein entries:     RN187_HUMAN (see all proteins):
    TRIM39    TRIM17

    RNF187 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for RNF187 (see all 251)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1999458071,2
    --228673070(+) GTGTG-/CTTTTT 1 -- us2k10--------
    rs113204361,2
    C,F--228673071(+) TGTGCT/-TTTTT 1 -- us2k1 trp33Minor allele frequency- -:0.33NA CSA 6
    rs1181069171,2
    C,F--228673184(+) ATTTGG/CCTATT 1 -- us2k11Minor allele frequency- C:0.03EA 120
    rs1506985901,2
    C--228673474(+) CAGATC/TTATAA 1 -- us2k10--------
    rs2002061421,2
    C--228673477(+) TTTAT-/AAAAAA 1 -- us2k10--------
    rs1125753261,2
    C--228673482(+) TAAAAT/ATTTTT 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1379857641,2
    C--228673584(+) TGGTTC/GAAGTG 1 -- us2k10--------
    rs120643221,2
    C,F--228673718(+) ccttgT/Ggatcc 1 -- us2k14Minor allele frequency- G:0.20NA WA 124
    rs1491739301,2
    --228673719(+) CTTGTA/GATCCG 1 -- us2k10--------
    rs1432783211,2
    --228673733(+) GCCTCA/GGCCTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RNF187 (228674762 - 228683889 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for RNF187:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv523935CNV Loss19592680
    nsv517545CNV Loss19592680
    nsv873270CNV Loss21882294
    nsv873255CNV Loss21882294
    dgv542n71CNV Loss21882294
    nsv468305CNV Gain19166990
    esv32853CNV Gain17666407
    nsv826908CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing RNF187
    DNA2.0 Custom Variant and Variant Library Synthesis for RNF187

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 613754    OMIM disorders: --


    RNF187 for disorders           About GeneDecksing


    Export disorders for RNF187 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for RNF187 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with RNF187)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Arginine methylation of the c-Jun coactivator RACO-1 is required for c-Jun/AP-1 activation. (PubMed id 23624934)1, 2 Davies C.C....Behrens A. (EMBO J. 2013)
    2. Identification of a co-activator that links growth factor signalling to c-Jun/AP-1 activation. (PubMed id 20852630)1, 2 Davies C.C....Behrens A. (Nat. Cell Biol. 2010)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    6. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    7. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    8. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (Cell 2010)
    9. Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry. (PubMed id 18781797)1 Meierhofer D.... Kaiser P. (J. Proteome Res. 2008)
    10. A protein interaction framework for human mRNA degradation. (PubMed id 15231747)1 Lehner B. and Sanderson C.M. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 149603 HGNC: 27146 AceView: LOC149603 Ensembl:ENSG00000168159 euGenes: HUgn149603
    ECgene: RNF187 H-InvDB: RNF187

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for RNF187 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for RNF187 gene:
    Search GeneIP for patents involving RNF187

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for RNF187  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for RNF187  
     OriGene qSTAR qPCR primer pairs in human, mouse for RNF187   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for RNF187   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RNF187   OriGene Custom Protein Services for RNF187  

     
     
     Block miRNA regulation of human, mouse, rat RNF187 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing RNF187
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNF187 Predesigned siRNA for gene silencing in human, mouse, rat RNF187
     QuantiFast Probe-based Assays in human, mouse, rat RNF187 QuantiTect SYBR Green Assays in human, mouse, rat RNF187
     PCR Arrays including human, mouse, rat RNF187 Search Chromatin IP Primers for RNF187
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RNF187  Search GeneGlobe Interaction Network for RNF187
     Regulatory tfbs in RNF187 promoter
     GenScript Custom Purified and Recombinant Proteins Services for RNF187 GenScript cDNA clones with any tag delivered in your preferred vector for RNF187
     GenScript Custom Assay Services for RNF187 GenScript Custom overexpressing Cell Line Services for RNF187
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for RNF187 (RN187)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     RNF187 antibodies
     Search for Antibodies for RNF187 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for RNF187
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for RNF187
     Antibodies for RNF187
     ELISAs for RNF187
     CLIAs for RNF187



     Browse ESI BIO Cell Lines and PureStem Progenitors for RNF187
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF187
     SwitchGear 3'UTR luciferase reporter plasmids for RNF187
     SwitchGear Promoter luciferase reporter plasmids for RNF187
     Search ThermoFisher Antibodies for RNF187
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat RNF187
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RNF187
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RNF187
     LSBio Antibodies in human, mouse, rat for RNF187
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RNF187 gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4