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Aliases for RNF187 Gene

Aliases for RNF187 Gene

  • Ring Finger Protein 187 2 3
  • RING-Type E3 Ubiquitin Transferase RNF187 3 4
  • Ring Domain AP-1 Co-Activator 1 2 3
  • RING Domain AP1 Coactivator 1 3 4
  • RING Finger Protein 187 4 5
  • RACO-1 3 4
  • E3 Ubiquitin-Protein Ligase RNF187 3
  • Protein RNF187 3
  • EC 4
  • RACO1 3

External Ids for RNF187 Gene

Previous GeneCards Identifiers for RNF187 Gene

  • GC01P224982
  • GC01P226740
  • GC01P228675
  • GC01P199189

Summaries for RNF187 Gene

GeneCards Summary for RNF187 Gene

RNF187 (Ring Finger Protein 187) is a Protein Coding gene. GO annotations related to this gene include ligase activity and ubiquitin-protein transferase activity.

UniProtKB/Swiss-Prot for RNF187 Gene

  • E3 ubiquitin-protein ligase that acts as a coactivator of JUN-mediated gene activation in response to growth factor signaling via the MAP3K1 pathway, independently from MAPK8.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF187 Gene

Genomics for RNF187 Gene

Regulatory Elements for RNF187 Gene

Enhancers for RNF187 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G228500 1.7 FANTOM5 Ensembl ENCODE dbSUPER 9.2 +13.8 13840 1.8 PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 ZNF48 ZNF766 ELK1 ZNF143 REST HIST3H3 HIST3H2A HIST3H2BB RPL23AP15 CICP26 OBSCN-AS1 OBSCN C1orf35 RNF187 LOC105373124
GH01G228489 1.3 ENCODE dbSUPER 9.7 +3.4 3389 1.6 PKNOX1 ATF1 CREB3L1 ARNT TCF12 ZNF121 ZNF766 ELK1 SP3 CAVIN1 ENSG00000226920 RNF187 OBSCN ENSG00000279306 LOC105373124
GH01G228485 1.4 ENCODE dbSUPER 6.9 +0.5 486 3.3 CREB3L1 AGO1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC CICP26 ENSG00000269890 RNF187 GJC2 ENSG00000279306 LOC105373124
GH01G228646 1.8 FANTOM5 Ensembl ENCODE 4.3 +161.0 160977 2.8 HDGF ARID4B SIN3A YBX1 FEZF1 DMAP1 ZNF2 ZNF302 ZNF416 ZNF207 NUP133 CICP26 C1orf35 ENSG00000269890 HMGN2P19 HIST3H3 TAF5L ABCB10 RHOU JMJD4
GH01G228205 1.5 FANTOM5 ENCODE dbSUPER 5.1 -278.7 -278682 6.3 RAD21 RARA ZNF121 GLIS2 GATA2 FOS ZNF263 PAF1 ZNF680 ZNF362 OBSCN RNF187 TRIM17 GJC2 OBSCN-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RNF187 on UCSC Golden Path with GeneCards custom track

Promoters for RNF187 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000021317 239 2201 CREB3L1 AGO1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC

Genomic Location for RNF187 Gene

228,487,061 bp from pter
228,496,188 bp from pter
9,128 bases
Plus strand

Genomic View for RNF187 Gene

Genes around RNF187 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF187 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF187 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF187 Gene

Proteins for RNF187 Gene

  • Protein details for RNF187 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    E3 ubiquitin-protein ligase RNF187
    Protein Accession:
    Secondary Accessions:
    • A6NL57
    • Q6P2J7
    • Q6PJR0

    Protein attributes for RNF187 Gene

    235 amino acids
    Molecular mass:
    26190 Da
    Quaternary structure:
    • Homodimer. Interacts with JUN, independently of JUN phosphorylation.
    • Sequence=AAH12758.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH12758.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence={ECO:0000305}; Sequence=CAI23328.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for RNF187 Gene

Post-translational modifications for RNF187 Gene

  • Arginine methylation by PRMT1 stabilizes RNF187 by facilitating K63-linked ubiquitin chain formation, and enables dimerization, c-Jun interaction and subsequent AP1 target gene expression.
  • Ubiquitinated; undergoes Lys-48-linked autoubiquitination in the absence of growth factors and MAP3K1-induced Lys-63-linked polyubiquitination. Lys-48-autoubiquitination leads to degradation by the proteasome, while MAP3K1-induced Lys-63-linked polyubiquitination results in the stabilization of the protein. Lys-48- and Lys-63-linked polyubiquitinations occur most probably on the same 3 C-terminal lysine residues (Lys-195, Lys-223 and Lys-224) and are thus mutually exclusive. Other sites of ubiquitination are not excluded.
  • Ubiquitination at isoforms=161, isoforms=195, isoforms=223, and isoforms=224
  • Modification sites at PhosphoSitePlus

Other Protein References for RNF187 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RNF187 Gene

Domains & Families for RNF187 Gene

Gene Families for RNF187 Gene

Protein Domains for RNF187 Gene

Suggested Antigen Peptide Sequences for RNF187 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The RING-type zinc finger domain is required for E3 ligase activity.
  • The RING-type zinc finger domain is required for E3 ligase activity.
genes like me logo Genes that share domains with RNF187: view

Function for RNF187 Gene

Molecular function for RNF187 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase that acts as a coactivator of JUN-mediated gene activation in response to growth factor signaling via the MAP3K1 pathway, independently from MAPK8.

Enzyme Numbers (IUBMB) for RNF187 Gene

Gene Ontology (GO) - Molecular Function for RNF187 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 20852630
GO:0005515 protein binding IPI 20852630
GO:0008270 zinc ion binding IEA --
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RNF187: view

Phenotypes for RNF187 Gene

genes like me logo Genes that share phenotypes with RNF187: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNF187 Gene

Localization for RNF187 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF187 Gene

Cytoplasm. Nucleus. Note=Predominantly located in the cytoplasm. Shuttles between the cytoplasm and the nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNF187 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 1

Gene Ontology (GO) - Cellular Components for RNF187 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 20852630
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA,IEA 20852630
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with RNF187: view

Pathways & Interactions for RNF187 Gene

SuperPathways for RNF187 Gene

No Data Available

UniProtKB/Swiss-Prot Q5TA31-RN187_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for RNF187 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation ISS --
GO:0016567 protein ubiquitination IEA --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IMP 20852630
GO:0045893 positive regulation of transcription, DNA-templated IMP 20852630
GO:0051865 protein autoubiquitination IDA 20852630
genes like me logo Genes that share ontologies with RNF187: view

No data available for Pathways by source and SIGNOR curated interactions for RNF187 Gene

Drugs & Compounds for RNF187 Gene

No Compound Related Data Available

Transcripts for RNF187 Gene

mRNA/cDNA for RNF187 Gene

Unigene Clusters for RNF187 Gene

Ring finger protein 187:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF187 Gene

No ASD Table

Relevant External Links for RNF187 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNF187 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNF187 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RNF187 Gene

This gene is overexpressed in Adrenal (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RNF187 Gene

Protein tissue co-expression partners for RNF187 Gene

NURSA nuclear receptor signaling pathways regulating expression of RNF187 Gene:


SOURCE GeneReport for Unigene cluster for RNF187 Gene:


Evidence on tissue expression from TISSUES for RNF187 Gene

  • Nervous system(4.1)
  • Kidney(2.7)
  • Lung(2.5)
  • Thyroid gland(2.2)
  • Adrenal gland(2.1)
genes like me logo Genes that share expression patterns with RNF187: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNF187 Gene

Orthologs for RNF187 Gene

This gene was present in the common ancestor of mammals.

Orthologs for RNF187 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RNF187 34 35
  • 92.34 (n)
(Mus musculus)
Mammalia Rnf187 34 16 35
  • 88.79 (n)
(Bos Taurus)
Mammalia RNF187 34 35
  • 87.09 (n)
(Rattus norvegicus)
Mammalia Rnf187 34
  • 87.09 (n)
Species where no ortholog for RNF187 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RNF187 Gene

Gene Tree for RNF187 (if available)
Gene Tree for RNF187 (if available)

Paralogs for RNF187 Gene

(2) SIMAP similar genes for RNF187 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RNF187: view

No data available for Paralogs for RNF187 Gene

Variants for RNF187 Gene

Sequence variations from dbSNP and Humsavar for RNF187 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000165786 -- 228,488,163(+) TCTCC(C/G)CACCC intron-variant
rs1000370748 -- 228,493,544(+) CTCCT(G/T)CCTCG intron-variant
rs1000741963 -- 228,493,785(+) ATGTG(C/T)GCTCT intron-variant
rs1000973426 -- 228,490,890(+) GATGG(-/GT)GTGTG intron-variant
rs1001536566 -- 228,495,564(+) AGCAT(-/CCCTGC)CCCTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RNF187 Gene

Variant ID Type Subtype PubMed ID
dgv841n54 CNV gain 21841781
esv32853 CNV gain 17666407
nsv1013500 CNV gain 25217958
nsv1130986 CNV deletion 24896259
nsv468305 CNV gain 19166990
nsv517545 CNV loss 19592680
nsv523935 CNV loss 19592680
nsv549296 CNV gain 21841781
nsv826908 CNV gain 20364138

Variation tolerance for RNF187 Gene

Gene Damage Index Score: 0.22; 4.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNF187 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF187 Gene

Disorders for RNF187 Gene

Relevant External Links for RNF187

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RNF187 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF187 Gene

Publications for RNF187 Gene

  1. RNF187 is Downregulated Following NF-I_B Inhibition in Late Erythroblasts. (PMID: 27259582) Forster L. … Ghassemifar R. (Biochem. Genet. 2016) 2 3 64
  2. Arginine methylation of the c-Jun coactivator RACO-1 is required for c-Jun/AP-1 activation. (PMID: 23624934) Davies C.C. … Behrens A. (EMBO J. 2013) 3 4 64
  3. Identification of a co-activator that links growth factor signalling to c-Jun/AP-1 activation. (PMID: 20852630) Davies C.C. … Behrens A. (Nat. Cell Biol. 2010) 3 4 64
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for RNF187 Gene

Sources for RNF187 Gene

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