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Aliases for RNF186 Gene

Aliases for RNF186 Gene

  • Ring Finger Protein 186 2 3
  • Hypothetical Protein FLJ20225 2
  • RACO1 6

External Ids for RNF186 Gene

Previous GeneCards Identifiers for RNF186 Gene

  • GC01M019886
  • GC01M020014
  • GC01M020140
  • GC01M018386

Summaries for RNF186 Gene

GeneCards Summary for RNF186 Gene

RNF186 (Ring Finger Protein 186) is a Protein Coding gene. Diseases associated with RNF186 include ulcerative colitis.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF186 Gene

Genomics for RNF186 Gene

Regulatory Elements for RNF186 Gene

Genomic Location for RNF186 Gene

Start:
19,814,029 bp from pter
End:
19,815,278 bp from pter
Size:
1,250 bases
Orientation:
Minus strand

Genomic View for RNF186 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNF186 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF186 Gene

Proteins for RNF186 Gene

  • Protein details for RNF186 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NXI6-RN186_HUMAN
    Recommended name:
    RING finger protein 186
    Protein Accession:
    Q9NXI6
    Secondary Accessions:
    • Q53GE0

    Protein attributes for RNF186 Gene

    Size:
    227 amino acids
    Molecular mass:
    24145 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RNF186 Gene

Proteomics data for RNF186 Gene at MOPED

Post-translational modifications for RNF186 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RNF186 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RNF186 Gene

Domains for RNF186 Gene

Gene Families for RNF186 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for RNF186 Gene

Suggested Antigen Peptide Sequences for RNF186 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NXI6

UniProtKB/Swiss-Prot:

RN186_HUMAN :
  • Q9NXI6
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF186: view

Function for RNF186 Gene

Gene Ontology (GO) - Molecular Function for RNF186 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with RNF186: view

Phenotypes for RNF186 Gene

GenomeRNAi human phenotypes for RNF186:
genes like me logo Genes that share phenotypes with RNF186: view

Animal Model Products

CRISPR Products

miRNA for RNF186 Gene

miRTarBase miRNAs that target RNF186

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNF186

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RNF186 Gene

Localization for RNF186 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF186 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNF186 Gene COMPARTMENTS Subcellular localization image for RNF186 gene
Compartment Confidence
plasma membrane 3
cytosol 1
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RNF186 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RNF186: view

Pathways for RNF186 Gene

SuperPathways for RNF186 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RNF186 Gene

None

No data available for Pathways by source for RNF186 Gene

Transcripts for RNF186 Gene

mRNA/cDNA for RNF186 Gene

(36) Selected AceView cDNA sequences:
(5) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RNF186 Gene

Ring finger protein 186:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNF186

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for RNF186

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF186 Gene

No ASD Table

Relevant External Links for RNF186 Gene

GeneLoc Exon Structure for
RNF186
ECgene alternative splicing isoforms for
RNF186

Expression for RNF186 Gene

mRNA expression in normal human tissues for RNF186 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNF186 Gene

This gene is overexpressed in Pancreas (18.6), Kidney - Cortex (15.7), Colon - Transverse (11.3), and Small Intestine - Terminal Ileum (4.9).

SOURCE GeneReport for Unigene cluster for RNF186 Gene Hs.124835

genes like me logo Genes that share expressions with RNF186: view

In Situ Assay Products

No data available for Protein expression and mRNA Expression by UniProt/SwissProt for RNF186 Gene

Orthologs for RNF186 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNF186 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNF186 35
  • 99.12 (n)
  • 98.68 (a)
RNF186 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RNF186 35
  • 77.88 (n)
  • 64.16 (a)
RNF186 36
  • 64 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNF186 35
  • 81.86 (n)
  • 74.88 (a)
RNF186 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnf186 35
  • 73.6 (n)
  • 66.81 (a)
Rnf186 16
Rnf186 36
  • 55 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RNF186 36
  • 54 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnf186 35
  • 76.67 (n)
  • 74.5 (a)
chicken
(Gallus gallus)
Aves RNF186 35
  • 57.01 (n)
  • 48.6 (a)
RNF186 36
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf186 35
  • 51.15 (n)
  • 42.53 (a)
Species with no ortholog for RNF186:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RNF186 Gene

ENSEMBL:
Gene Tree for RNF186 (if available)
TreeFam:
Gene Tree for RNF186 (if available)

Paralogs for RNF186 Gene

No data available for Paralogs for RNF186 Gene

Variants for RNF186 Gene

Sequence variations from dbSNP and Humsavar for RNF186 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1317209 -- 19,813,543(-) GTTAC(C/T)GTCTT downstream-variant-500B
rs1541184 -- 19,814,790(+) ACCAC(C/T)GCCTC synonymous-codon, reference
rs1541185 - 19,815,035(+) CACAG(C/T)GGTGG missense, reference
rs2154358 -- 19,816,713(-) TTTTC(C/T)TTTCA upstream-variant-2KB
rs3767216 -- 19,813,847(+) AAACA(A/G)CCAGG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for RNF186 Gene

Variant ID Type Subtype PubMed ID
nsv870984 CNV Gain 21882294

Relevant External Links for RNF186 Gene

HapMap Linkage Disequilibrium report
RNF186

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF186 Gene

Disorders for RNF186 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for RNF186 Gene including...

Search for RNF186 Gene in MalaCards »

Relevant External Links for RNF186

Genetic Association Database (GAD)
RNF186
Human Genome Epidemiology (HuGE) Navigator
RNF186
genes like me logo Genes that share disorders with RNF186: view

No data available for UniProtKB/Swiss-Prot for RNF186 Gene

Publications for RNF186 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  5. Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study. (PMID: 19122664) Silverberg M.S. … Duerr R.H. (Nat. Genet. 2009) 3 48

Products for RNF186 Gene

Sources for RNF186 Gene

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