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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RNF186 Gene

protein-coding   GIFtS: 45
GCID: GC01M020140

ring finger protein 186
 Explore 1 disease affiliated with
RNF186 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RNF186    

Aliases
for RNF186 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Ring Finger Protein 1861 2
FLJ202251
RP11-91K11.12

External Ids:    HGNC: 259781   Entrez Gene: 545462   Ensembl: ENSG000001788287   UniProtKB: Q9NXI63   

Export aliases for RNF186 gene to outside databases

Previous GC identifers: GC01M019886 GC01M020014 GC01M018386


Summaries
for RNF186 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for RNF186 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004610.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RNF186 gene promoter:
         USF1   SREBP-1c   NRSF form 1   NRSF form 2   SREBP-1b   FOXC1   SREBP-1a   FOXO4   USF-1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RNF186 promoter sequence
   Search SABiosciences Chromatin IP Primers for RNF186

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF186


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.13   Ensembl cytogenetic band:  1p36.13   HGNC cytogenetic band: 1p36.13

RNF186 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF186 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M020140:  view genomic region     (about GC identifiers)

Start:
 20,140,522 bp from pter      End:
 20,141,771 bp from pter
Size:
 1,250 bases      Orientation:
 minus strand

Proteins
for RNF186 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RN186_HUMAN, Q9NXI6 (See protein sequence)
Recommended Name: RING finger protein 186  
Size: 227 amino acids; 24145 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q53GE0

Explore the universe of human proteins at neXtProt for RNF186: NX_Q9NXI6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NXI6

    • RNF186 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_061935.1  
    ENSEMBL proteins: 
     ENSP00000364263  

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    Uscn Proteins for RNF186

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--


    RNF186 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for RNF186 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RNF186 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q9NXI6

    ProtoNet protein and cluster: Q9NXI6

    1 Blocks protein family: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: RN186_HUMAN, Q9NXI6
    Similarity: Contains 1 RING-type zinc finger


    Function
    for RNF186 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
    Products:            		Browse 3'-UTR reporter clones for miRNA target validation
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    hsa-miR-10b hsa-miR-10a
    SwitchGear 3'UTR luciferase reporter plasmid: RNF186 3' UTR sequence
    Inhib. RNA
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    In Situ Assay
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008270zinc ion binding IEA--


    RNF186 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for RNF186:
     Increased cell death HMECs cel 


    Pathways & Interactions
    for RNF186 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNF186

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for RNF186 (Q9NXI63 ENSP000003642634) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE2D2P628373, ENSP000003817174I2D: score=2 STRING: ENSP00000381717
    UBE2HP622563, ENSP000003478364I2D: score=2 STRING: ENSP00000347836
    About this table

    Drugs & Compounds
    for RNF186 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RNF186
    Search CenterWatch for drugs/clinical trials and news about RNF186 / RN186 

    Transcripts
    for RNF186 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section
    REFSEQ mRNAs for RNF186 gene: 
    NM_019062.1  

    Unigene Cluster for RNF186:

    Ring finger protein 186
    Hs.124835  [show with all ESTs]
    Unigene Representative Sequence: BC030960
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000375121(uc001bcr.3)

    miRNA
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    hsa-miR-10b hsa-miR-10a
    SwitchGear 3'UTR luciferase reporter plasmid: RNF186 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AK000232.1 AK222991.1 BC030960.1 BC051880.1 CR457228.1 

    1 DOTS entry:

    DT.109061 

    24/36 AceView cDNA sequences (see all 36):

    BC030960 NM_019062 AA877253 AA947216 BC051880 AI492437 AK000232 AA812473 
    BX280297 AI885588 AI670878 CR457228 BI763786 AW137906 AW204284 AI380838 
    AI345999 AI393998 AI792264 BI834216 BI836104 AI949722 AI732334 AI927647 

    GeneLoc Exon Structure


    Expression
    for RNF186 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RNF186 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACAAGATGGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    RNF186 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyRenal Collecting Duct SystemCollecting Duct CellsKidney
    KidneyEpithelial TubuleKidney
    KidneyRenal Collecting Duct SystemKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See RNF186 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RNF186

    SOURCE GeneReport for Unigene cluster: Hs.124835
        SABiosciences Custom PCR Arrays for RNF186
    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF186

    Orthologs
    for RNF186 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of human and mouse.

    Orthologs for RNF186 gene from 1/6 species (see all 6)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Rnf1861 , 5 ring finger protein 1861, 5 75.3(n)1
    69.64(a)1    		   4 (70.57 cM)5
    668251  NM_025786.31  NP_080062.41 
     1389671125 


    ENSEMBL Gene Tree for RNF186 (if available)
    TreeFam Gene Tree for RNF186 (if available) 

    Paralogs
    for RNF186 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for RNF186 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/127 NCBI SNPs in RNF186 are shown (see all 127)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs13172091,2
    		C,F,O,A,H,--20140036(-) GTTACC/TGTCTT 1 -- int134Minor allele frequency- T:0.28MN NS EA NA WA CSA 3519
    rs1832752471,2
    		--20140096(+) GCTGGC/TCCCAC 1 -- int10--------
    rs1391800561,2
    		--20140164(+) GGCACA/GGAGTG 1 -- int10--------
    rs617683581,2
    		--20140262(+) CCCCTG/ACAGCT 1 -- int11Minor allele frequency- A:0.50NA 2
    rs1871741101,2
    		--20140307(+) CCCCAA/GCCCTA 1 -- int10--------
    rs37672161,2
    		C,F,A,H,--20140340(+) AAACAA/GCCAGG 1 -- int131Minor allele frequency- N:0.00EA NA NS WA CSA 4461
    rs37672171,2
    		C,F,H,--20140389(+) GTTAGA/TGGAAG 1 -- int114Minor allele frequency- T:0.10NS EA NA 1558
    rs1917265021,2
    		--20140394(+) AGGAAA/GCGCAG 1 -- int10--------
    rs1464852161,2
    		--20140395(+) GGAAGC/TGCAGT 1 -- int10--------
    rs412641051,2
    		F,--20140560(+) TCTACA/CATGGC 1 -- ut311Minor allele frequency- C:0.09EA 120

    HapMap Linkage Disequilibrium report for RNF186 (20140522 - 20141771 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for RNF186: --

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    Disorders / Diseases
    for RNF186 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RNF186 for disorders           About GeneDecksing

    1 disease for RNF186:    About MalaCards
    ulcerative colitis

    Human Genome Epidemiology (HuGE) Navigator: RNF186 (1 document)

    Export disorders for RNF186 gene to outside databases

    Publications
    for RNF186 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RNF186 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with RNF186)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    5. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
    6. Genome-wide association identifies multiple ulcerativ e colitis susceptibility loci. (PubMed id 20228799)1 McGovern D.P....Weersma R.K. (2010)
    7. Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study. (PubMed id 19122664)1 Silverberg M.S....Duerr R.H. (2009)
    8. A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. (PubMed id 19690564)1 van Wijk S.J....Timmers H.T. (2009)
    9. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)

    External Searches for RNF186 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing RNF186 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54546 HGNC: 25978 AceView: FLJ20225 Ensembl:ENSG00000178828 euGenes: HUgn54546
    ECgene: RNF186 H-InvDB: RNF186

    Other Databases showing RNF186 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RNF186 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RNF186 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for RNF186 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RNF186 gene:
    Search GeneIP for patents involving RNF186

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for RNF186 gene

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    Advanced Cell Diagnostics
    About This Section

     
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