Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RNF186 Gene

Aliases for RNF186 Gene

  • Ring Finger Protein 186 2 3 5
  • Hypothetical Protein FLJ20225 2

External Ids for RNF186 Gene

Previous GeneCards Identifiers for RNF186 Gene

  • GC01M019886
  • GC01M020014
  • GC01M020140
  • GC01M018386

Summaries for RNF186 Gene

GeneCards Summary for RNF186 Gene

RNF186 (Ring Finger Protein 186) is a Protein Coding gene. Diseases associated with RNF186 include Hartnup Disorder.

Additional gene information for RNF186 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF186 Gene

Genomics for RNF186 Gene

Regulatory Elements for RNF186 Gene

Enhancers for RNF186 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H019764 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10.8 +49.6 49631 2 STAT1 JUN FOSL1 JUND ZNF366 STAT3 ID3 KDM1A FOS MAFK TMCO4 AKR7A3 RNF186 ENSG00000235434 PLA2G2A GC01P019759
GH01H019757 1.1 Ensembl ENCODE dbSUPER 10.8 +56.5 56491 2 SOX5 SOX13 ZNF623 ZKSCAN1 ZNF121 JUND POLR2A FOS SETDB1 TMCO4 RNF186 ENSG00000235434 GC01P019759 PIR33395
GH01H019859 0.9 ENCODE 11.1 -45.8 -45790 2 HDAC1 TCF12 EGR1 FOS ATF7 EGR2 CEBPB ZEB2 ZNF398 ZNF623 HP1BP3 OTUD3 ENSG00000235434 RNF186 EMC1 TMCO4 PIR53184 GC01M019829
GH01H019863 0.8 ENCODE 11.1 -48.6 -48612 1 GTF2F1 TBP SOX13 JUN ZMYM3 CEBPG TCF12 GTF3C2 GATA3 POLR3A OTUD3 UBR4 EMC1 ENSG00000235434 RNF186 DDOST TMCO4 HP1BP3 PIR53184 GC01M019829
GH01H019866 0.7 ENCODE 11.1 -51.7 -51699 1 JUN TSC22D4 FOSL1 FOS PRDM10 KLF8 SP3 USF2 ZNF398 ZSCAN21 RNF186 ENSG00000235434 TMCO4 OTUD3 PIR53184 GC01M019829
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RNF186 on UCSC Golden Path with GeneCards custom track

Genomic Location for RNF186 Gene

Chromosome:
1
Start:
19,814,029 bp from pter
End:
19,815,278 bp from pter
Size:
1,250 bases
Orientation:
Minus strand

Genomic View for RNF186 Gene

Genes around RNF186 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF186 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF186 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF186 Gene

Proteins for RNF186 Gene

  • Protein details for RNF186 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NXI6-RN186_HUMAN
    Recommended name:
    RING finger protein 186
    Protein Accession:
    Q9NXI6
    Secondary Accessions:
    • Q53GE0

    Protein attributes for RNF186 Gene

    Size:
    227 amino acids
    Molecular mass:
    24145 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RNF186 Gene

Post-translational modifications for RNF186 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RNF186 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RNF186 Gene

Domains & Families for RNF186 Gene

Gene Families for RNF186 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for RNF186 Gene

Suggested Antigen Peptide Sequences for RNF186 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RNF186: view

No data available for UniProtKB/Swiss-Prot for RNF186 Gene

Function for RNF186 Gene

Phenotypes From GWAS Catalog for RNF186 Gene

Gene Ontology (GO) - Molecular Function for RNF186 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RNF186: view
genes like me logo Genes that share phenotypes with RNF186: view

Animal Model Products

CRISPR Products

miRNA for RNF186 Gene

miRTarBase miRNAs that target RNF186

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RNF186
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNF186 Gene

Localization for RNF186 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF186 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNF186 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for RNF186 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RNF186: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RNF186 Gene

Pathways & Interactions for RNF186 Gene

SuperPathways for RNF186 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RNF186 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RNF186 Gene

Drugs & Compounds for RNF186 Gene

No Compound Related Data Available

Transcripts for RNF186 Gene

mRNA/cDNA for RNF186 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(36) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RNF186 Gene

Ring finger protein 186:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RNF186
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for RNF186 Gene

No ASD Table

Relevant External Links for RNF186 Gene

GeneLoc Exon Structure for
RNF186
ECgene alternative splicing isoforms for
RNF186

Expression for RNF186 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNF186 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNF186 Gene

This gene is overexpressed in Pancreas (x18.6), Kidney - Cortex (x15.7), Colon - Transverse (x11.3), and Small Intestine - Terminal Ileum (x4.9).

NURSA nuclear receptor signaling pathways regulating expression of RNF186 Gene:

RNF186

SOURCE GeneReport for Unigene cluster for RNF186 Gene:

Hs.124835

Evidence on tissue expression from TISSUES for RNF186 Gene

  • Intestine(4.3)
  • Kidney(4.2)
  • Pancreas(4.2)
genes like me logo Genes that share expression patterns with RNF186: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNF186 Gene

Orthologs for RNF186 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNF186 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNF186 33 34
  • 99.12 (n)
dog
(Canis familiaris)
Mammalia RNF186 33 34
  • 81.86 (n)
cow
(Bos Taurus)
Mammalia RNF186 33 34
  • 77.88 (n)
rat
(Rattus norvegicus)
Mammalia Rnf186 33
  • 76.67 (n)
mouse
(Mus musculus)
Mammalia Rnf186 33 16 34
  • 73.6 (n)
oppossum
(Monodelphis domestica)
Mammalia RNF186 34
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves RNF186 33 34
  • 57.01 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf186 33
  • 51.15 (n)
Species where no ortholog for RNF186 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RNF186 Gene

ENSEMBL:
Gene Tree for RNF186 (if available)
TreeFam:
Gene Tree for RNF186 (if available)

Paralogs for RNF186 Gene

No data available for Paralogs for RNF186 Gene

Variants for RNF186 Gene

Sequence variations from dbSNP and Humsavar for RNF186 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1002502163 -- 19,813,623(+) ACTGC(A/C)GTCCT downstream-variant-500B
rs1003768412 -- 19,814,664(+) TTTGC(A/C)CTTAC reference, missense
rs1003816950 -- 19,816,070(+) TGCCC(A/G)GGGTC upstream-variant-2KB
rs1003982515 -- 19,816,371(+) CAAAT(G/T)GCGGG upstream-variant-2KB
rs1004311936 -- 19,816,657(+) CTCAC(C/T)ATCCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RNF186 Gene

Variant ID Type Subtype PubMed ID
nsv1003518 CNV loss 25217958

Variation tolerance for RNF186 Gene

Residual Variation Intolerance Score: 89.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.16; 69.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNF186 Gene

Human Gene Mutation Database (HGMD)
RNF186
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNF186

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF186 Gene

Disorders for RNF186 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RNF186 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
hartnup disorder
  • hartnup disease
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for RNF186

Genetic Association Database (GAD)
RNF186
Human Genome Epidemiology (HuGE) Navigator
RNF186
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RNF186
genes like me logo Genes that share disorders with RNF186: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RNF186 Gene

Publications for RNF186 Gene

  1. Genome-wide association identifies multiple ulcerative colitis susceptibility loci. (PMID: 20228799) McGovern DP … Seielstad M (Nature genetics 2010) 3 45 60
  2. Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study. (PMID: 19122664) Silverberg MS … Duerr RH (Nature genetics 2009) 3 45 60
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for RNF186 Gene

Sources for RNF186 Gene

Content
Loading form....