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RNF186 Gene

protein-coding   GIFtS: 49
GCID: GC01M020140

Ring Finger Protein 186

  See RNF186-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ring Finger Protein 1861 2
Hypothetical Protein FLJ202251
RACO15

External Ids:    HGNC: 259781   Entrez Gene: 545462   Ensembl: ENSG000001788287   OMIM: 6137545   UniProtKB: Q9NXI63   

Export aliases for RNF186 gene to outside databases

Previous GC identifers: GC01M019886 GC01M020014 GC01M018386


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RNF186 Gene:
RNF186 (ring finger protein 186) is a protein-coding gene. Diseases associated with RNF186 include ulcerative colitis.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the RNF186 gene promoter:
         USF1   SREBP-1c   NRSF form 1   NRSF form 2   SREBP-1b   FOXC1   SREBP-1a   FOXO4   USF-1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RNF186 promoter sequence
   Search Chromatin IP Primers for RNF186

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNF186


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.13   Ensembl cytogenetic band:  1p36.13   HGNC cytogenetic band: 1p36.13

RNF186 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF186 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M020140:  view genomic region     (about GC identifiers)

Start:
20,140,522 bp from pter      End:
20,141,771 bp from pter
Size:
1,250 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RN186_HUMAN, Q9NXI6 (See protein sequence)
Recommended Name: RING finger protein 186  
Size: 227 amino acids; 24145 Da
Secondary accessions: Q53GE0

Explore the universe of human proteins at neXtProt for RNF186: NX_Q9NXI6

Explore proteomics data for RNF186 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RNF186 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_061935.1  
    ENSEMBL proteins: 
     ENSP00000364263  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers

    3 InterPro protein domains:
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q9NXI6

    ProtoNet protein and cluster: Q9NXI6

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: RN186_HUMAN, Q9NXI6
    Similarity: Contains 1 RING-type zinc finger


    Find genes that share domains with RNF186           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with RNF186           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for RNF186:
     Increased cell death HMECs cel 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for RNF186

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    hsa-mir-335-5p (MIRT017282)

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    hsa-miR-10b hsa-miR-10a
    SwitchGear 3'UTR luciferase reporter plasmidRNF186 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RN186_HUMAN, Q9NXI6: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    cytosol1
    golgi apparatus1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with RNF186           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RNF186
    Interactions:

        Search GeneGlobe Interaction Network for RNF186

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for RNF186 (Q9NXI63 ENSP000003642634) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE2D2P628373, ENSP000003817174I2D: score=2 STRING: ENSP00000381717
    UBE2HP622563, ENSP000003478364I2D: score=2 STRING: ENSP00000347836
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for RNF186 (RN186)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RNF186 gene: 
    NM_019062.1  

    Unigene Cluster for RNF186:

    Ring finger protein 186
    Hs.124835  [show with all ESTs]
    Unigene Representative Sequence: BC030960
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000375121(uc001bcr.3)
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate RNF186:
    hsa-miR-10b hsa-miR-10a
    SwitchGear 3'UTR luciferase reporter plasmidRNF186 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat RNF186
      QuantiFast Probe-based Assays in human, mouse, rat RNF186

    Additional mRNA sequence: 

    AK000232.1 AK222991.1 BC030960.1 BC051880.1 CR457228.1 

    1 DOTS entry:

    DT.109061 

    Selected AceView cDNA sequences (see all 36):

    AI885588 AI492437 BX280297 AK000232 BC051880 BC030960 AA877253 NM_019062 
    AA812473 AA947216 BI836104 CR457228 BI834216 AI393998 BI763786 AW137906 
    AI380838 AI949722 AI345999 AI792264 AI670878 AW204284 AI732334 AI631840 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RNF186 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAAGATGGG
    RNF186 Expression
    About this image


    RNF186 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Kidney (Urinary System)    fully expand to see all 3 entries
             Collecting Duct Cells Renal Collecting Duct System
             Renal Collecting Duct System
     
     Epithelial Cells
             Collecting Duct Cells Renal Collecting Duct System
     
     Colon (Gastrointestinal Tract)
    RNF186 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RNF186 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.124835
        Custom PCR Arrays for RNF186
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF186

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for RNF186 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnf1861 , 5 ring finger protein 1861, 5 73.6(n)1
    66.81(a)1
      4 (70.57 cM)5
    668251  NM_025786.31  NP_080062.41 
     1389671125 
    chicken
    (Gallus gallus)
    Aves RNF1861 ring finger protein 186 57.01(n)
    48.6(a)
      101751836  XM_004947482.1  XP_004947539.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia rnf1861 ring finger protein 186 51.15(n)
    42.53(a)
      101731751  XM_004916423.1  XP_004916480.1 


    ENSEMBL Gene Tree for RNF186 (if available)
    TreeFam Gene Tree for RNF186 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RNF186 (see all 150)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs13172091,2
    C,F,O,A,H--20140036(-) GTTACC/TGTCTT 1 -- int134Minor allele frequency- T:0.28MN NS EA NA WA CSA 3519
    rs1832752471,2
    --20140096(+) GCTGGC/TCCCAC 1 -- int10--------
    rs1391800561,2
    C--20140164(+) GGCACA/GGAGTG 1 -- int10--------
    rs617683581,2
    C,F--20140262(+) CCCCTG/ACAGCT 1 -- int11Minor allele frequency- A:0.50NA 2
    rs1871741101,2
    --20140307(+) CCCCAA/GCCCTA 1 -- int10--------
    rs37672161,2
    C,F,A,H--20140340(+) AAACAA/GCCAGG 1 -- int131Minor allele frequency- N:0.00EA NA NS WA CSA 4461
    rs37672171,2
    C,F,H--20140389(+) GTTAGA/TGGAAG 1 -- int114Minor allele frequency- T:0.10NS EA NA 1558
    rs1917265021,2
    --20140394(+) AGGAAA/GCGCAG 1 -- int10--------
    rs1464852161,2
    C--20140395(+) GGAAGC/TGCAGT 1 -- int10--------
    rs412641051,2
    C,F--20140560(+) TCTACA/CATGGC 1 -- ut311Minor allele frequency- C:0.09EA 120

    HapMap Linkage Disequilibrium report for RNF186 (20140522 - 20141771 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for RNF186:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv870984CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RNF186
    DNA2.0 Custom Variant and Variant Library Synthesis for RNF186

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613754    OMIM disorders: --

    1 disease for RNF186:    
    About MalaCards
    ulcerative colitis


    Find genes that share disorders with RNF186           About GenesLikeMe

    Genetic Association Database (GAD): RNF186
    Human Genome Epidemiology (HuGE) Navigator: RNF186 (1 document)

    Export disorders for RNF186 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RNF186 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with RNF186)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association identifies multiple ulcerative colitis susceptibility loci. (PubMed id 20228799)1, 4 McGovern D.P....Seielstad M. (Nat. Genet. 2010)
    2. Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study. (PubMed id 19122664)1, 4 Silverberg M.S....Duerr R.H. (Nat. Genet. 2009)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    7. Genome-wide association study of ulcerative colitis in Koreans suggests extensive overlapping of genetic susceptibility with Caucasians. (PubMed id 23511034)1 Yang S.K....Song K. (Inflamm. Bowel Dis. 2013)
    8. Deep resequencing of GWAS loci identifies rare variants in CARD9, IL23R and RNF186 that are associated with ulcerative colitis. (PubMed id 24068945)1 Beaudoin M....Rioux J.D. (PLoS Genet. 2013)
    9. A novel RING finger E3 ligase RNF186 regulate ER stress-mediated apoptosis through interaction with BNip1. (PubMed id 23896122)1 Wang P....Tang J. (Cell. Signal. 2013)
    10. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (J. Cell. Sci. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54546 HGNC: 25978 AceView: FLJ20225 Ensembl:ENSG00000178828 euGenes: HUgn54546
    ECgene: RNF186 H-InvDB: RNF186

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RNF186 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RNF186 gene:
    Search GeneIP for patents involving RNF186

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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