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Aliases for RNF186 Gene

Aliases for RNF186 Gene

  • Ring Finger Protein 186 2 3 5
  • Hypothetical Protein FLJ20225 2

External Ids for RNF186 Gene

Previous GeneCards Identifiers for RNF186 Gene

  • GC01M019886
  • GC01M020014
  • GC01M020140
  • GC01M018386

Summaries for RNF186 Gene

GeneCards Summary for RNF186 Gene

RNF186 (Ring Finger Protein 186) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF186 Gene

Genomics for RNF186 Gene

Regulatory Elements for RNF186 Gene

Enhancers for RNF186 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RNF186 on UCSC Golden Path with GeneCards custom track

Genomic Location for RNF186 Gene

19,814,029 bp from pter
19,815,278 bp from pter
1,250 bases
Minus strand

Genomic View for RNF186 Gene

Genes around RNF186 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF186 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF186 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF186 Gene

Proteins for RNF186 Gene

  • Protein details for RNF186 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RING finger protein 186
    Protein Accession:
    Secondary Accessions:
    • Q53GE0

    Protein attributes for RNF186 Gene

    227 amino acids
    Molecular mass:
    24145 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RNF186 Gene

Proteomics data for RNF186 Gene at MOPED

Post-translational modifications for RNF186 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RNF186 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RNF186 Gene

Domains & Families for RNF186 Gene

Gene Families for RNF186 Gene

Protein Domains for RNF186 Gene

Suggested Antigen Peptide Sequences for RNF186 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 RING-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF186: view

Function for RNF186 Gene

genes like me logo Genes that share phenotypes with RNF186: view

Animal Model Products

miRNA for RNF186 Gene

miRTarBase miRNAs that target RNF186

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNF186 Gene

Localization for RNF186 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF186 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for RNF186 Gene COMPARTMENTS Subcellular localization image for RNF186 gene
Compartment Confidence
plasma membrane 3

No data available for Gene Ontology (GO) - Cellular Components for RNF186 Gene

Pathways & Interactions for RNF186 Gene

SuperPathways for RNF186 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RNF186 Gene


No data available for Pathways by source and SIGNOR curated interactions for RNF186 Gene

Drugs & Compounds for RNF186 Gene

No Compound Related Data Available

Transcripts for RNF186 Gene

mRNA/cDNA for RNF186 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(36) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RNF186 Gene

Ring finger protein 186:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNF186 Gene

No ASD Table

Relevant External Links for RNF186 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNF186 Gene

mRNA expression in normal human tissues for RNF186 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNF186 Gene

This gene is overexpressed in Pancreas (x18.6), Kidney - Cortex (x15.7), Colon - Transverse (x11.3), and Small Intestine - Terminal Ileum (x4.9).

SOURCE GeneReport for Unigene cluster for RNF186 Gene Hs.124835

genes like me logo Genes that share expression patterns with RNF186: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for RNF186 Gene

Orthologs for RNF186 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNF186 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RNF186 35
  • 77.88 (n)
  • 64.16 (a)
RNF186 36
  • 64 (a)
(Canis familiaris)
Mammalia RNF186 35
  • 81.86 (n)
  • 74.88 (a)
RNF186 36
  • 72 (a)
(Mus musculus)
Mammalia Rnf186 35
  • 73.6 (n)
  • 66.81 (a)
Rnf186 16
Rnf186 36
  • 55 (a)
(Pan troglodytes)
Mammalia RNF186 35
  • 99.12 (n)
  • 98.68 (a)
RNF186 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Rnf186 35
  • 76.67 (n)
  • 74.5 (a)
(Monodelphis domestica)
Mammalia RNF186 36
  • 54 (a)
(Gallus gallus)
Aves RNF186 35
  • 57.01 (n)
  • 48.6 (a)
RNF186 36
  • 45 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf186 35
  • 51.15 (n)
  • 42.53 (a)
Species with no ortholog for RNF186:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RNF186 Gene

Gene Tree for RNF186 (if available)
Gene Tree for RNF186 (if available)

Paralogs for RNF186 Gene

No data available for Paralogs for RNF186 Gene

Variants for RNF186 Gene

Sequence variations from dbSNP and Humsavar for RNF186 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1541185 - 19,815,035(+) CACAG(C/T)GGTGG reference, missense
rs35541730 - 19,814,480(+) GGAGG(G/T)CCAGC reference, missense
rs1317209 -- 19,813,543(-) GTTAC(C/T)GTCTT downstream-variant-500B
rs1541184 -- 19,814,790(+) ACCAC(C/T)GCCTC reference, synonymous-codon
rs2154358 -- 19,816,713(-) TTTTC(C/T)TTTCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RNF186 Gene

Variant ID Type Subtype PubMed ID
nsv870984 CNV Gain 21882294

Variation tolerance for RNF186 Gene

Residual Variation Intolerance Score: 89.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.16; 69.50% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RNF186 Gene

Disorders for RNF186 Gene

Relevant External Links for RNF186

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RNF186 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF186 Gene

Publications for RNF186 Gene

  1. Genome-wide association identifies multiple ulcerative colitis susceptibility loci. (PMID: 20228799) McGovern D.P. … Seielstad M. (Nat. Genet. 2010) 3 48 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Genome-wide association study of ulcerative colitis in Koreans suggests extensive overlapping of genetic susceptibility with Caucasians. (PMID: 23511034) Yang S.K. … Song K. (Inflamm. Bowel Dis. 2013) 3
  4. A novel RING finger E3 ligase RNF186 regulate ER stress-mediated apoptosis through interaction with BNip1. (PMID: 23896122) Wang P. … Tang J. (Cell. Signal. 2013) 3
  5. Deep resequencing of GWAS loci identifies rare variants in CARD9, IL23R and RNF186 that are associated with ulcerative colitis. (PMID: 24068945) Beaudoin M. … Rioux J.D. (PLoS Genet. 2013) 3

Products for RNF186 Gene

Sources for RNF186 Gene