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Aliases for RNF185 Gene

Aliases for RNF185 Gene

  • Ring Finger Protein 185 2 3
  • E3 Ubiquitin-Protein Ligase RNF185 3
  • Hypothetical Protein FLJ38628 2
  • RING Finger Protein 185 4
  • BSK65-MONO1 3
  • BSK65-MONO2 3
  • BSK65-PANC1 3
  • BSK65-PANC2 3
  • BSK65-TEST1 3
  • BSK65-TEST2 3
  • BSK65-TEST3 3
  • EC 6.3.2.- 4

External Ids for RNF185 Gene

Previous GeneCards Identifiers for RNF185 Gene

  • GC22P029881
  • GC22P031556
  • GC22P014517

Summaries for RNF185 Gene

GeneCards Summary for RNF185 Gene

RNF185 (Ring Finger Protein 185) is a Protein Coding gene. Among its related pathways are Protein processing in endoplasmic reticulum. GO annotations related to this gene include ligase activity. An important paralog of this gene is RNF5.

UniProtKB/Swiss-Prot for RNF185 Gene

  • E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating Lys-63-linked polyubiquitination of BNIP1. Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway. Preferentially associates with the E2 enzymes UBE2J1 and UBE2J2.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF185 Gene

Genomics for RNF185 Gene

Regulatory Elements for RNF185 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RNF185 Gene

Start:
31,160,152 bp from pter
End:
31,207,019 bp from pter
Size:
46,868 bases
Orientation:
Plus strand

Genomic View for RNF185 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNF185 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF185 Gene

Proteins for RNF185 Gene

  • Protein details for RNF185 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96GF1-RN185_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase RNF185
    Protein Accession:
    Q96GF1
    Secondary Accessions:
    • A8K5C1
    • A9X3T8
    • Q8N900

    Protein attributes for RNF185 Gene

    Size:
    192 amino acids
    Molecular mass:
    20459 Da
    Quaternary structure:
    • Interacts with ATG5 and BNIP1.

    Alternative splice isoforms for RNF185 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNF185 Gene

Proteomics data for RNF185 Gene at MOPED

Post-translational modifications for RNF185 Gene

  • Ubiquitination at Lys80 and Lys87
  • Modification sites at PhosphoSitePlus

Other Protein References for RNF185 Gene

No data available for DME Specific Peptides for RNF185 Gene

Domains for RNF185 Gene

Gene Families for RNF185 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for RNF185 Gene

Graphical View of Domain Structure for InterPro Entry

Q96GF1

UniProtKB/Swiss-Prot:

RN185_HUMAN :
  • Q96GF1
Domain:
  • The RING-type zinc finger domain is responsible for E3 ubiquitin ligase activity
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF185: view

Function for RNF185 Gene

Molecular function for RNF185 Gene

UniProtKB/Swiss-Prot Function: E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating Lys-63-linked polyubiquitination of BNIP1. Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway. Preferentially associates with the E2 enzymes UBE2J1 and UBE2J2.
UniProtKB/Swiss-Prot Induction: Up-regulated by unfolded protein response (UPR) and ER stress.

Enzyme Numbers (IUBMB) for RNF185 Gene

Gene Ontology (GO) - Molecular Function for RNF185 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19549727
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with RNF185: view

Phenotypes for RNF185 Gene

GenomeRNAi human phenotypes for RNF185:
genes like me logo Genes that share phenotypes with RNF185: view

Animal Model Products

CRISPR Products

miRNA for RNF185 Gene

miRTarBase miRNAs that target RNF185

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNF185

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for RNF185 Gene

Localization for RNF185 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF185 Gene

Mitochondrion outer membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNF185 Gene COMPARTMENTS Subcellular localization image for RNF185 gene
Compartment Confidence
mitochondrion 5
nucleus 3
peroxisome 2
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for RNF185 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005741 mitochondrial outer membrane IEA --
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RNF185: view

Pathways for RNF185 Gene

genes like me logo Genes that share pathways with RNF185: view

Pathways by source for RNF185 Gene

1 KEGG pathway for RNF185 Gene

UniProtKB/Swiss-Prot Q96GF1-RN185_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for RNF185 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006914 autophagy IEA --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with RNF185: view

Transcripts for RNF185 Gene

Unigene Clusters for RNF185 Gene

Ring finger protein 185:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNF185

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF185 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ·
SP1: - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - -
SP4: -
SP5: - - - - - - - - - - - -
SP6: -
SP7: - - -
SP8: - - - - - - -
SP9: - - - - - - -
SP10: - - - - - - -
SP11: - - - - - - -
SP12: - - - - - -
SP13: - - - - - - -
SP14: - - - - - - -
SP15: - - - - - - - - - - - - - -
SP16: - - - - - -
SP17:
SP18: - -

ExUns: 11c · 11d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

Relevant External Links for RNF185 Gene

GeneLoc Exon Structure for
RNF185
ECgene alternative splicing isoforms for
RNF185

Expression for RNF185 Gene

mRNA expression in normal human tissues for RNF185 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RNF185 Gene

SOURCE GeneReport for Unigene cluster for RNF185 Gene Hs.517553

genes like me logo Genes that share expressions with RNF185: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RNF185 Gene

Orthologs for RNF185 Gene

This gene was present in the common ancestor of animals.

Orthologs for RNF185 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNF185 35
  • 100 (n)
  • 100 (a)
RNF185 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RNF185 35
  • 92.71 (n)
  • 98.44 (a)
RNF185 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNF185 35
  • 94.62 (n)
  • 100 (a)
RNF185 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnf185 35
  • 93.06 (n)
  • 98.44 (a)
Rnf185 16
Rnf185 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RNF185 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RNF185 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnf185 35
  • 92.36 (n)
  • 98.96 (a)
chicken
(Gallus gallus)
Aves RNF185 35
  • 82.12 (n)
  • 92.19 (a)
RNF185 36
  • 93 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.13633 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.4501 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8264 35
zebrafish
(Danio rerio)
Actinopterygii rnf185 35
  • 73.26 (n)
  • 86.46 (a)
rnf185 36
  • 86 (a)
OneToOne
wufk32c04 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006041 35
  • 57.92 (n)
  • 58.12 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32581 36
  • 37 (a)
ManyToMany
CG32847 36
  • 43 (a)
ManyToMany
CG8974 35
  • 57.46 (n)
  • 61.96 (a)
CG8974 36
  • 40 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea rnf-5 35
  • 54.64 (n)
  • 55.06 (a)
rnf-5 36
  • 39 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2160 35
Species with no ortholog for RNF185:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RNF185 Gene

ENSEMBL:
Gene Tree for RNF185 (if available)
TreeFam:
Gene Tree for RNF185 (if available)

Paralogs for RNF185 Gene

Paralogs for RNF185 Gene

Selected SIMAP similar genes for RNF185 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for RNF185 Gene

genes like me logo Genes that share paralogs with RNF185: view

Variants for RNF185 Gene

Sequence variations from dbSNP and Humsavar for RNF185 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs6651 -- 31,206,786(-) GCCGA(A/G)GGATG utr-variant-3-prime, nc-transcript-variant
rs8595 -- 31,206,655(-) GCCAG(C/G)CTGGC utr-variant-3-prime, nc-transcript-variant
rs13158 -- 31,206,201(+) CTTCA(C/T)AGTCC utr-variant-3-prime, nc-transcript-variant
rs886074 -- 31,179,304(-) ATGGG(C/T)CTACC intron-variant
rs1034589 -- 31,183,247(-) acact(A/G)atcaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNF185 Gene

Variant ID Type Subtype PubMed ID
nsv459871 CNV Loss 19166990
nsv507933 CNV Insertion 20534489

Relevant External Links for RNF185 Gene

HapMap Linkage Disequilibrium report
RNF185

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF185 Gene

Disorders for RNF185 Gene

No disorders were found for RNF185 Gene.

No data available for UniProtKB/Swiss-Prot for RNF185 Gene

Publications for RNF185 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. RNF185, a novel mitochondrial ubiquitin E3 ligase, regulates autophagy through interaction with BNIP1. (PMID: 21931693) Tang F. … Tang J. (PLoS ONE 2011) 3 4

Products for RNF185 Gene

Sources for RNF185 Gene

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