Aliases for RNF185 Gene
External Ids for RNF185 Gene
Previous GeneCards Identifiers for RNF185 Gene
GeneCards Summary for RNF185 Gene
RNF185 (Ring Finger Protein 185) is a Protein Coding gene. Diseases associated with RNF185 include Cystic Fibrosis. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Calnexin/calreticulin cycle. GO annotations related to this gene include ligase activity. An important paralog of this gene is RNF5.
UniProtKB/Swiss-Prot for RNF185 Gene
E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating Lys-63-linked polyubiquitination of BNIP1. Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway. Preferentially associates with the E2 enzymes UBE2J1 and UBE2J2.