Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



RNF185 Gene

protein-coding   GIFtS: 51
GCID: GC22P031556

Ring Finger Protein 185

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Ring Finger Protein 1851 2 3     BSK65-TEST12
Hypothetical Protein FLJ386281     BSK65-TEST22
BSK65-MONO12     BSK65-TEST32
BSK65-MONO22     E3 Ubiquitin-Protein Ligase RNF1852
BSK65-PANC12     EC 6.3.2.-3
BSK65-PANC22     

External Ids:    HGNC: 267831   Entrez Gene: 914452   Ensembl: ENSG000001389427   UniProtKB: Q96GF13   
ORGUL members:         

Export aliases for RNF185 gene to outside databases

Previous GC identifers: GC22P029881 GC22P014517


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for RNF185 Gene:
RNF185 (ring finger protein 185) is a protein-coding gene. Diseases associated with RNF185 include malaria. GO annotations related to this gene include ligase activity. An important paralog of this gene is RNF5.

UniProtKB/Swiss-Prot: RN185_HUMAN, Q96GF1
Function: Mitochondrial E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating
'Lys-63'-linked polyubiquitination of BNIP1




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000022.11  NT_011520.13  NC_018933.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RNF185 gene promoter:
         USF1   HTF   C/EBPalpha   MEF-2A   AREB6   Ik-2   USF-1   STAT3   aMEF-2   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNF185 promoter sequence
   Search Chromatin IP Primers for RNF185

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNF185


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.2   Ensembl cytogenetic band:  22q12.2   HGNC cytogenetic band: 22q12.2

RNF185 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF185 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P031556:  view genomic region     (about GC identifiers)

Start:
31,556,138 bp from pter      End:
31,603,005 bp from pter
Size:
46,868 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for RNF185

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: RN185_HUMAN, Q96GF1 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase RNF185  
Size: 192 amino acids; 20459 Da
Subunit: Interacts with ATG5 and BNIP1
Secondary accessions: A8K5C1 A9X3T8 Q8N900
Alternative splicing: 2 isoforms:  Q96GF1-1   Q96GF1-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RNF185: NX_Q96GF1

Explore proteomics data for RNF185 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys80, Lys87
  • Modification sites at PhosphoSitePlus

  • See RNF185 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001129297.1  NP_689480.2  

    ENSEMBL proteins: 
     ENSP00000320508   ENSP00000427755   ENSP00000266252   ENSP00000410916  

    RNF185 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for RNF185
    OriGene Protein Over-expression Lysate for RNF185
    OriGene Custom MassSpec
    OriGene Custom Protein Services for RNF185
    GenScript Custom Purified and Recombinant Proteins Services for RNF185
    Novus Biologicals RNF185 Protein
    Novus Biologicals RNF185 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RNF185

    RNF185 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for RNF185
    Novus Biologicals RNF185 Antibodies
    Abcam antibodies for RNF185
    Cloud-Clone Corp. Antibodies for RNF185
    ThermoFisher Antibody for RNF185
    LSBio Antibodies in human, mouse, rat for RNF185

    RNF185 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RNF185
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RNF185
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RNF185
    Cloud-Clone Corp. CLIAs for RNF185


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers

    3 InterPro protein domains:
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q96GF1

    ProtoNet protein and cluster: Q96GF1

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: RN185_HUMAN, Q96GF1
    Domain: The RING-type zinc finger domain is responsible for E3 ubiquitin ligase activity
    Similarity: Contains 1 RING-type zinc finger


    RNF185 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RN185_HUMAN, Q96GF1
    Function: Mitochondrial E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating
    'Lys-63'-linked polyubiquitination of BNIP1

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0016874ligase activity IEA--
    GO:0046872metal ion binding ----
         
    RNF185 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for RNF185:
     Increased cell number in G2M,   Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RNF185
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RNF185

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RNF185
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RNF185

    miRNA
    Products:
        
    miRTarBase miRNAs that target RNF185:
    hsa-mir-615-3p (MIRT040228), hsa-mir-423-3p (MIRT042563)

    Block miRNA regulation of human, mouse, rat RNF185 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RNF185 (see all 28):
    hsa-miR-330-5p hsa-miR-188-5p hsa-miR-134 hsa-miR-200a hsa-miR-4299 hsa-miR-520a-5p hsa-miR-877* hsa-miR-141
    SwitchGear 3'UTR luciferase reporter plasmidRNF185 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RNF185
    Predesigned siRNA for gene silencing in human, mouse, rat RNF185

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RNF185

    Clone
    Products:
         
    OriGene clones in human, mouse for RNF185 (see all 18)
    OriGene ORF clones in mouse, rat for RNF185
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): RNF185 (NM_152267)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNF185
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF185

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RNF185
    Browse ESI BIO Cell Lines and PureStem Progenitors for RNF185 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF185


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    RN185_HUMAN, Q96GF1: Mitochondrion outer membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    nucleus3
    peroxisome2
    lysosome1
    vacuole1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005741mitochondrial outer membrane IEA--
    GO:0016021integral component of membrane IEA--

    RNF185 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for RNF185 About    
    See pathways by source

    SuperPathContained pathways About
    1Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for RNF185):
        Protein processing in endoplasmic reticulum

    UniProtKB/Swiss-Prot: RN185_HUMAN, Q96GF1
    Pathway: Protein modification; protein ubiquitination


    RNF185 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RNF185
    Interactions:

        Search GeneGlobe Interaction Network for RNF185

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RNF185 (Q96GF13 ENSP000003205084) via UniProtKB, MINT, STRING, and/or I2D (see all 56)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE2D2P628373, ENSP000003817174I2D: score=3 STRING: ENSP00000381717
    UBE2D3P610773, ENSP000003497224I2D: score=2 STRING: ENSP00000349722
    UBE2IP632793, ENSP000003248974I2D: score=2 STRING: ENSP00000324897
    UBE2V1Q134043, ENSP000003403054I2D: score=2 STRING: ENSP00000340305
    UBE2WQ96B023, ENSP000003974534I2D: score=2 STRING: ENSP00000397453
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006914autophagy IEA--
    GO:0016567protein ubiquitination IEA--

    RNF185 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RNF185 (RN185)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for RNF185 gene (3 alternative transcripts): 
    NM_001135824.1  NM_001135825.1  NM_152267.3  

    Unigene Cluster for RNF185:

    Ring finger protein 185
    Hs.517553  [show with all ESTs]
    Unigene Representative Sequence: NR_024210
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000494514 ENST00000326132(uc010gwh.3 uc003akb.3 uc011alm.2 uc003akc.3 uc003ake.3)
    ENST00000471384 ENST00000518626 ENST00000468921 ENST00000266252 ENST00000426256

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RNF185 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RNF185 (see all 28):
    hsa-miR-330-5p hsa-miR-188-5p hsa-miR-134 hsa-miR-200a hsa-miR-4299 hsa-miR-520a-5p hsa-miR-877* hsa-miR-141
    SwitchGear 3'UTR luciferase reporter plasmidRNF185 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RNF185
    Predesigned siRNA for gene silencing in human, mouse, rat RNF185
    Clone
    Products:
         
    OriGene clones in human, mouse for RNF185 (see all 18)
    OriGene ORF clones in mouse, rat for RNF185
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): RNF185 (NM_152267)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNF185
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF185
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RNF185
    OriGene qSTAR qPCR primer pairs in human, mouse for RNF185
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RNF185
      QuantiTect SYBR Green Assays in human, mouse, rat RNF185
      QuantiFast Probe-based Assays in human, mouse, rat RNF185

    Additional mRNA sequence: 

    AK027035.1 AK075154.1 AK095947.1 AK291236.1 AK297414.1 BC009504.2 BC012817.1 BC017302.1 
    BC026040.1 BC033166.1 BC035684.1 BC069286.1 BC069446.1 BC069815.1 BX648019.1 CR456349.1 
    DQ296559.1 DQ296560.1 DQ296562.1 DQ296563.1 DQ296564.1 DQ296565.1 NR_024209.1 NR_024210.1 
    NR_024211.1 NR_024212.1 

    Selected DOTS entries (see all 36):

    DT.91793518  DT.449349  DT.100844134  DT.100708724  DT.120673512  DT.120673495  DT.100844132  DT.100844133 
    DT.40109431  DT.121643843  DT.121273929  DT.120673498  DT.75148291  DT.100844130  DT.120673582  DT.100731635 
    DT.100844128  DT.120673641  DT.120673649  DT.100713469  DT.100765800  DT.100844131  DT.100844135  DT.102830284 

    Selected AceView cDNA sequences (see all 710):

    BX410567 BX418572 BQ446350 BQ049703 BX339974 BQ053390 BF223062 BQ677938 
    AI394573 BG057045 BM477490 BF446788 BC069815 BF110136 BX339081 AA334283 
    BQ101030 BQ882463 BC069286 BQ128290 CD722284 BQ421824 BX410566 CR456349 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RNF185 (see all 18)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ·
    SP1:                                            -     -     -     -     -     -     -     -                                   -                                 
    SP2:                                            -     -     -     -     -     -     -     -                 -                 -                                 
    SP3:                                            -     -           -     -     -     -                                                                           
    SP4:                                                              -                                                                                             
    SP5:                                            -     -     -     -     -     -     -     -                 -     -     -     -                                 

    ExUns: 11c · 11d
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for RNF185

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    RNF185 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGACTGCCAA
    RNF185 Expression
    About this image

    RNF185 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RNF185 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.517553
        Custom PCR Arrays for RNF185
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RNF185
    OriGene qSTAR qPCR primer pairs in human, mouse for RNF185
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RNF185
    QuantiTect SYBR Green Assays in human, mouse, rat RNF185
    QuantiFast Probe-based Assays in human, mouse, rat RNF185
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF185

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for RNF185 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnf1851 , 5 ring finger protein 1851, 5 93.06(n)1
    98.44(a)1
      11 (2.40 cM)5
    1936701  NM_145355.41  NP_663330.21 
     34159825 
    chicken
    (Gallus gallus)
    Aves RNF1851 ring finger protein 185 82.12(n)
    92.19(a)
      416965  NM_001007840.1  NP_001007841.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.136332 Xenopus laevis transcribed sequence with weak similarity more 75.93(n)    CA973515.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufk32c042 Danio rerio cDNA clone MGC73070 IMAGE4145700, complete more 83.33(n)    BC059445.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG89741 CG8974 57.46(n)
    61.96(a)
      32532  NM_167463.2  NP_727897.1 
    worm
    (Caenorhabditis elegans)
    Secernentea rnf-51 rnf-5 54.64(n)
    55.06(a)
      175532  NM_065429.3  NP_497830.1 


    ENSEMBL Gene Tree for RNF185 (if available)
    TreeFam Gene Tree for RNF185 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for RNF185 gene
    RNF52  
    1 SIMAP similar gene for RNF185 using alignment to 2 protein entries:     RN185_HUMAN (see all proteins):
    RNF5

    RNF185 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for RNF185
    PGOHUM00000245683


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for RNF185 (see all 971)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs59978901,2
    F,H--31554155(+) atcatG/Agtcac 6 -- us2k16Minor allele frequency- A:0.01NS EA WA NA 658
    rs169893861,2
    C,F,H--31554288(+) GCTTGG/ATTTCA 6 -- us2k19Minor allele frequency- A:0.04NA NS EA WA 680
    rs1408029301,2
    --31554340(+) CTTGAG/TCACAG 6 -- us2k10--------
    rs1501288951,2
    --31554383(+) TTCATC/TTATGA 6 -- us2k10--------
    rs1881084871,2
    --31554395(+) CTTATA/TTCATC 6 -- us2k10--------
    rs1927126751,2
    --31554403(+) ATCTAC/TTATTT 6 -- us2k10--------
    rs717946161,2
    C--31554441(+) CACTC-/TTGTCGC 6 -- us2k10--------
    rs1841273441,2
    --31554446(+) TTGTCA/GCCCAG 6 -- us2k10--------
    rs1895055571,2
    C--31554539(+) GTAGCC/TGGGAT 6 -- us2k10--------
    rs1924143431,2
    --31554564(+) ACCACA/GCCTGG 6 -- us2k10--------

    HapMap Linkage Disequilibrium report for RNF185 (31556138 - 31603005 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RNF185:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv507933CNV Insertion20534489
    nsv459871CNV Loss19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RNF185
    DNA2.0 Custom Variant and Variant Library Synthesis for RNF185

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    1 disease for RNF185:    
    About MalaCards
    malaria


    RNF185 for disorders           About GeneDecksing


    Export disorders for RNF185 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for RNF185 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with RNF185)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. RNF185, a novel mitochondrial ubiquitin E3 ligase, regulates autophagy through interaction with BNIP1. (PubMed id 21931693)1, 2 Tang F....Tang J. (PLoS ONE 2011)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    6. RNF185 is a novel E3 ligase of endoplasmic reticulum-associated degradation (ERAD) that targets cystic fibrosis transmembrane conductance regulator (CFTR). (PubMed id 24019521)1 El Khouri E....Delaunay-Moisan A. (J. Biol. Chem. 2013)
    7. Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (J. Proteome Res. 2012)
    8. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    9. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    10. Direct and indirect control of mitogen-activated protein kinase pathway-associated components, BRAP/IMP E3 ubiquitin ligase and CRAF/RAF1 kinase, by the deubiquitylating enzyme USP15. (PubMed id 23105109)1 Hayes S.D....UrbAc S. (J. Biol. Chem. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 91445 HGNC: 26783 AceView: LIMK2 Ensembl:ENSG00000138942 euGenes: HUgn91445
    ECgene: RNF185 Kegg: 91445 H-InvDB: RNF185

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for RNF185 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for RNF185 gene:
    Search GeneIP for patents involving RNF185

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for RNF185  
     OriGene qPCR primer pairs and template standards for RNF185   OriGene Protein Over-expression Lysate for RNF185  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for RNF185  
     OriGene qSTAR qPCR primer pairs in human, mouse for RNF185   OriGene Purified Protein for RNF185  
     OriGene ORF clones in mouse, rat for RNF185   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RNF185   OriGene Custom Protein Services for RNF185  

     
     
     Block miRNA regulation of human, mouse, rat RNF185 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing RNF185
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNF185 Predesigned siRNA for gene silencing in human, mouse, rat RNF185
     QuantiFast Probe-based Assays in human, mouse, rat RNF185 QuantiTect SYBR Green Assays in human, mouse, rat RNF185
     Custom PCR Arrays for RNF185 Search Chromatin IP Primers for RNF185
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RNF185  Search GeneGlobe Interaction Network for RNF185
     Regulatory tfbs in RNF185 promoter
     GenScript Custom Purified and Recombinant Proteins Services for RNF185 GenScript cDNA clones with any tag delivered in your preferred vector for RNF185
     GenScript Custom Assay Services for RNF185 GenScript Custom overexpressing Cell Line Services for RNF185
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for RNF185 (RN185)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     RNF185 antibodies
     RNF185 proteins
     RNF185 lysates
     Antibodies for RNF185
     See all of Abcam's Antibodies, Kits and Proteins for RNF185
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for RNF185
     Antibodies for RNF185
     ELISAs for RNF185
     CLIAs for RNF185



     Browse ESI BIO Cell Lines and PureStem Progenitors for RNF185
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF185
     SwitchGear 3'UTR luciferase reporter plasmids for RNF185
     SwitchGear Promoter luciferase reporter plasmids for RNF185
     ThermoFisher Antibody for RNF185
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF185
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RNF185
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RNF185
     LSBio Antibodies in human, mouse, rat for RNF185
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RNF185 gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4