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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RNF185 Gene

protein-coding   GIFtS: 49
GCID: GC22P031556

Ring Finger Protein 185

  Search for RNF185
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Ring Finger Protein 1851 2 3     BSK65-TEST12
Hypothetical Protein FLJ386281     BSK65-TEST22
BSK65-MONO12     BSK65-TEST32
BSK65-MONO22     E3 Ubiquitin-Protein Ligase RNF1852
BSK65-PANC12     EC 6.3.2.-3
BSK65-PANC22     

External Ids:    HGNC: 267831   Entrez Gene: 914452   Ensembl: ENSG000001389427   UniProtKB: Q96GF13   
ORGUL members:         
NONCODE14:n406672 n406669 n406670      

Export aliases for RNF185 gene to outside databases

Previous GC identifers: GC22P029881 GC22P014517


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RNF185 Gene: 
RNF185 (ring finger protein 185) is a protein-coding gene, and is affiliated with the lncRNA class. GO annotations related to this gene include zinc ion binding and ligase activity. An important paralog of this gene is RNF5.

UniProtKB/Swiss-Prot: RN185_HUMAN, Q96GF1
Function: Mitochondrial E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating
'Lys-63'-linked polyubiquitination of BNIP1




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.2  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RNF185 gene promoter:
         USF1   HTF   C/EBPalpha   MEF-2A   AREB6   Ik-2   USF-1   STAT3   aMEF-2   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNF185 promoter sequence
   Search SABiosciences Chromatin IP Primers for RNF185

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF185


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.2   Ensembl cytogenetic band:  22q12.2   HGNC cytogenetic band: 22q12.2

RNF185 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF185 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P031556:  view genomic region     (about GC identifiers)

Start:
31,556,138 bp from pter      End:
31,603,005 bp from pter
Size:
46,868 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for RNF185

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RN185_HUMAN, Q96GF1 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase RNF185  
Size: 192 amino acids; 20459 Da
Subunit: Interacts with ATG5 and BNIP1
Subcellular location: Mitochondrion outer membrane; Multi-pass membrane protein
Secondary accessions: A8K5C1 A9X3T8 Q8N900
Alternative splicing: 2 isoforms:  Q96GF1-1   Q96GF1-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RNF185: NX_Q96GF1

Explore proteomics data for RNF185 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96GF1

  • RNF185 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RNF185 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001129297.1  NP_689480.2  

    ENSEMBL proteins: 
     ENSP00000320508   ENSP00000427755   ENSP00000266252   ENSP00000410916  

    Human Recombinant Protein Products for RNF185: 
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    Novus Biologicals RNF185 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RNF185 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005741mitochondrial outer membrane IEA--
    GO:0016021integral to membrane IEA--

    RNF185 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RNF: RING-type (C3HC4) zinc fingers

    3 InterPro protein domains:
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q96GF1

    ProtoNet protein and cluster: Q96GF1

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: RN185_HUMAN, Q96GF1
    Domain: The RING-type zinc finger domain is responsible for E3 ubiquitin ligase activity
    Similarity: Contains 1 RING-type zinc finger


    RNF185 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RN185_HUMAN, Q96GF1
    Function: Mitochondrial E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating
    'Lys-63'-linked polyubiquitination of BNIP1

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0016874ligase activity IEA--
    GO:0046872metal ion binding ----
         
    RNF185 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for RNF185:
     Increased cell number in G2M,   Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RNF185 
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    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate RNF185 (see all 28):
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    SwitchGear 3'UTR luciferase reporter plasmidRNF185 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RNF185 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for RNF185):
        Protein processing in endoplasmic reticulum

    UniProtKB/Swiss-Prot: RN185_HUMAN, Q96GF1
    Pathway: Protein modification; protein ubiquitination


    RNF185 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNF185

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/56 Interacting proteins for RNF185 (Q96GF13 ENSP000003205084) via UniProtKB, MINT, STRING, and/or I2D (see all 56)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE2D2P628373, ENSP000003817174I2D: score=3 STRING: ENSP00000381717
    UBE2D3P610773, ENSP000003497224I2D: score=2 STRING: ENSP00000349722
    UBE2IP632793, ENSP000003248974I2D: score=2 STRING: ENSP00000324897
    UBE2V1Q134043, ENSP000003403054I2D: score=2 STRING: ENSP00000340305
    UBE2WQ96B023, ENSP000003974534I2D: score=2 STRING: ENSP00000397453
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006914autophagy IEA--
    GO:0016567protein ubiquitination IEA--

    RNF185 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RNF185 (RN185)

    Search CenterWatch for drugs/clinical trials and news about RNF185 / RN185

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RNF185 gene (3 alternative transcripts): 
    NM_001135824.1  NM_001135825.1  NM_152267.3  

    Unigene Cluster for RNF185:

    Ring finger protein 185
    Hs.517553  [show with all ESTs]
    Unigene Representative Sequence: NR_024210
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000494514 ENST00000326132(uc010gwh.3 uc003akb.3 uc011alm.2 uc003akc.3 uc003ake.3)
    ENST00000471384 ENST00000518626 ENST00000468921 ENST00000266252 ENST00000426256

    miRNA
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    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate RNF185 (see all 28):
    hsa-miR-330-5p hsa-miR-188-5p hsa-miR-134 hsa-miR-200a hsa-miR-4299 hsa-miR-520a-5p hsa-miR-877* hsa-miR-141
    SwitchGear 3'UTR luciferase reporter plasmidRNF185 3' UTR sequence
    Inhib. RNA
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNF185
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNF185

    Additional mRNA sequence: 

    AK027035.1 AK075154.1 AK095947.1 AK291236.1 AK297414.1 BC009504.2 BC012817.1 BC017302.1 
    BC026040.1 BC033166.1 BC035684.1 BC069286.1 BC069446.1 BC069815.1 BX648019.1 CR456349.1 
    DQ296559.1 DQ296560.1 DQ296562.1 DQ296563.1 DQ296564.1 DQ296565.1 NR_024209.1 NR_024210.1 
    NR_024211.1 NR_024212.1 

    24/36 DOTS entries (see all 36):

    DT.91793518  DT.449349  DT.100844134  DT.100708724  DT.120673512  DT.120673495  DT.100844132  DT.100844133 
    DT.40109431  DT.121643843  DT.121273929  DT.120673498  DT.75148291  DT.100844130  DT.120673582  DT.100731635 
    DT.100844128  DT.120673641  DT.120673649  DT.100713469  DT.100765800  DT.100844131  DT.100844135  DT.102830284 

    24/710 AceView cDNA sequences (see all 710):

    BF446788 AU103075 BF727384 BQ446350 BM477490 BM905856 BM673877 BQ421824 
    BX112414 BC013051 T31342 BU153542 BC033166 BQ677938 BV178956 BM756163 
    BX337350 AI968122 AA401915 AI394573 BX339081 BQ708973 BM563538 BX380756 

    GeneLoc Exon Structure

    5/18 Alternative Splicing Database (ASD) splice patterns (SP) for RNF185 (see all 18)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ·
    SP1:                                            -     -     -     -     -     -     -     -                                   -                                 
    SP2:                                            -     -     -     -     -     -     -     -                 -                 -                                 
    SP3:                                            -     -           -     -     -     -                                                                           
    SP4:                                                              -                                                                                             
    SP5:                                            -     -     -     -     -     -     -     -                 -     -     -     -                                 

    ExUns: 11c · 11d
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for RNF185

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RNF185 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGACTGCCAA
    RNF185 Expression
    About this image


    See RNF185 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RNF185

    SOURCE GeneReport for Unigene cluster: Hs.517553
        SABiosciences Custom PCR Arrays for RNF185
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RNF185 gene from 7/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnf1851 , 5 ring finger protein 1851, 5 93.06(n)1
    98.44(a)1
      11 (2.40 cM)5
    1936701  NM_145355.41  NP_663330.21 
     34159825 
    chicken
    (Gallus gallus)
    Aves RNF1851 ring finger protein 185 83.51(n)
    93.75(a)
      416965  NM_001007840.1  NP_001007841.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.136332 Xenopus laevis transcribed sequence with weak similarity more 75.93(n)    CA973515.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufk32c042 Danio rerio cDNA clone MGC73070 IMAGE4145700, complete more 83.33(n)    BC059445.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG89741 CG8974 60.94(n)
    66.87(a)
      32532  NM_206726.1  NP_996449.1 
    worm
    (Caenorhabditis elegans)
    Secernentea rnf-51 Protein RNF-5 56.13(n)
    56.32(a)
      175532  NM_065429.2  NP_497830.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G237801 ubiquitin-protein ligase RNF5 51.48(n)
    47.34(a)
      816910  NM_127941.3  NP_179958.1 


    ENSEMBL Gene Tree for RNF185 (if available)
    TreeFam Gene Tree for RNF185 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RNF185 gene
    RNF52  
    1 SIMAP similar gene for RNF185 using alignment to 2 protein entries:     RN185_HUMAN (see all proteins):
    RNF5

    RNF185 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for RNF185
    PGOHUM00000245683


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/971 SNPs in RNF185 are shown (see all 971)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs59978901,2
    F,H--31554155(+) atcatG/Agtcac 6 -- us2k16Minor allele frequency- A:0.01NS EA WA NA 658
    rs169893861,2
    C,F,H--31554288(+) GCTTGG/ATTTCA 6 -- us2k19Minor allele frequency- A:0.04NA NS EA WA 680
    rs1408029301,2
    --31554340(+) CTTGAG/TCACAG 6 -- us2k10--------
    rs1501288951,2
    --31554383(+) TTCATC/TTATGA 6 -- us2k10--------
    rs1881084871,2
    --31554395(+) CTTATA/TTCATC 6 -- us2k10--------
    rs1927126751,2
    --31554403(+) ATCTAC/TTATTT 6 -- us2k10--------
    rs717946161,2
    C--31554441(+) CACTC-/TTGTCGC 6 -- us2k10--------
    rs1841273441,2
    --31554446(+) TTGTCA/GCCCAG 6 -- us2k10--------
    rs1895055571,2
    C--31554539(+) GTAGCC/TGGGAT 6 -- us2k10--------
    rs1924143431,2
    --31554564(+) ACCACA/GCCTGG 6 -- us2k10--------

    HapMap Linkage Disequilibrium report for RNF185 (31556138 - 31603005 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RNF185:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv507933CNV Insertion20534489
    nsv459871CNV Loss19166990

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RNF185 gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with RNF185)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. RNF185, a novel mitochondrial ubiquitin E3 ligase, regulates autophagy through interaction with BNIP1. (PubMed id 21931693)1, 2 Tang F....Tang J. (2011)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    6. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    8. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    9. Direct and indirect control of mitogen-activated prote in kinase pathway-associated components, BRAP/IMP E3 ubiquitin ligase and CRAF/R AF1 kinase, by the deubiquitylating enzyme USP15. (PubMed id 23105109)1 Hayes S.D....Urbe S. (2012)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 91445 HGNC: 26783 AceView: LIMK2 Ensembl:ENSG00000138942 euGenes: HUgn91445
    ECgene: RNF185 Kegg: 91445 H-InvDB: RNF185

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RNF185 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RNF185 gene:
    Search GeneIP for patents involving RNF185

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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