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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RNF183 Gene

protein-coding   GIFtS: 44
GCID: GC09M116059

Ring Finger Protein 183

  Search for RNF183
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ring Finger Protein 1831 2

External Ids:    HGNC: 287211   Entrez Gene: 1380652   Ensembl: ENSG000001651887   UniProtKB: Q96D593   

Export aliases for RNF183 gene to outside databases

Previous GC identifers: GC09M113139 GC09M115099 GC09M085666


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RNF183 Gene: 
RNF183 (ring finger protein 183) is a protein-coding gene. GO annotations related to this gene include zinc ion binding. An important paralog of this gene is LOC646862.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_008470.19  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RNF183 gene promoter:
         GR   RP58   p300   HNF-1   FOXJ2 (long isoform)   FOXJ2   HNF-1A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNF183 promoter sequence
   Search SABiosciences Chromatin IP Primers for RNF183

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF183


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q32   Ensembl cytogenetic band:  9q32   HGNC cytogenetic band: 9q32

RNF183 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF183 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M116059:  view genomic region     (about GC identifiers)

Start:
116,059,373 bp from pter      End:
116,065,656 bp from pter
Size:
6,284 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RN183_HUMAN, Q96D59 (See protein sequence)
Recommended Name: RING finger protein 183  
Size: 192 amino acids; 21675 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)

Explore the universe of human proteins at neXtProt for RNF183: NX_Q96D59

Explore proteomics data for RNF183 at MOPED 

RNF183 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

RNF183 Protein Expression

REFSEQ proteins: NP_659488.2  
ENSEMBL proteins: 
 ENSP00000417176   ENSP00000420740   ENSP00000419454   ENSP00000417943  

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016021integral to membrane IEA--

RNF183 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
RNF: RING-type (C3HC4) zinc fingers

3 InterPro protein domains:
 IPR017907 Znf_RING_CS
 IPR001841 Znf_RING
 IPR013083 Znf_RING/FYVE/PHD

Graphical View of Domain Structure for InterPro Entry Q96D59

ProtoNet protein and cluster: Q96D59

1 Blocks protein domain: IPB001841 Zn-finger

UniProtKB/Swiss-Prot: RN183_HUMAN, Q96D59
Similarity: Contains 1 RING-type zinc finger


RNF183 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
GO:0008270zinc ion binding IEA--
     
RNF183 for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for RNF183:
 Increased cell number in S 

Animal Models:
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SwitchGear 3'UTR luciferase reporter plasmidRNF183 3' UTR sequence
Inhib. RNA
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNF183

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5/12 Interacting proteins for RNF183 (Q96D592, 3 ENSP000004207404) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
InteractantInteraction Details
GeneCardExternal ID(s)
FATE1Q969F02, 3, ENSP000003593754MINT-66409 I2D: score=4 STRING: ENSP00000359375
KXD1Q9BQD32, 3, ENSP000002223074MINT-67419 I2D: score=3 STRING: ENSP00000222307
IFFO1Q0D2I53, ENSP000003493644I2D: score=3 STRING: ENSP00000349364
FBP1P094673, ENSP000003644754I2D: score=3 STRING: ENSP00000364475
EWSR1Q018443, ENSP000003810314I2D: score=2 STRING: ENSP00000381031
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RNF183 (RN183)

Search CenterWatch for drugs/clinical trials and news about RNF183 / RN183

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RNF183 gene: 
NM_145051.3  

Unigene Cluster for RNF183:

Ring finger protein 183
Hs.729641  [show with all ESTs]
Unigene Representative Sequence: AK091940
7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000441031(uc004bgz.3) ENST00000416588 ENST00000478815(uc022bmd.1)
ENST00000297894(uc004bha.3) ENST00000478493 ENST00000489339 ENST00000443976

miRNA
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hsa-miR-15a hsa-miR-1271 hsa-miR-938 hsa-miR-424 hsa-miR-129-3p hsa-miR-195 hsa-miR-129* hsa-miR-15b
SwitchGear 3'UTR luciferase reporter plasmidRNF183 3' UTR sequence
Inhib. RNA
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Additional mRNA sequence: 

AK091940.1 BC013036.2 

4 DOTS entries:

DT.99943120  DT.40282405  DT.95364356  DT.95258548 

24/29 AceView cDNA sequences (see all 29):

AW139879 BE463594 AA928883 BE501488 AK091940 BE468156 BF448088 AA514593 
AA337967 BI494082 AI923733 AX747267 AW614405 BC013036 AK055759 BE326299 
AI860474 NM_145051 BI494083 BM797555 BE266322 AI244282 AW183348 BE796148 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RNF183 expression in normal human tissues (normalized intensities)      RNF183 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GAAGGGCAGA
RNF183 Expression
About this image


RNF183 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/3 selected tissues (see all 3) fully expand
 
 Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
         Myoblasts Mandibular Arch Muscles
 
 Kidney (Urinary System)
 
 Uterus (Reproductive System)

See RNF183 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RNF183

SOURCE GeneReport for Unigene cluster: Hs.729641
    SABiosciences Custom PCR Arrays for RNF183
Primer
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNF183
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF183

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for RNF183 gene from 1/6 species (see all 6)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Rnf1831 , 5 ring finger protein 1831, 5 85.79(n)1
88.42(a)1
  4 (33.13 cM)5
760721  NM_153504.31  NP_705724.11 
 624275405 


ENSEMBL Gene Tree for RNF183 (if available)
TreeFam Gene Tree for RNF183 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for RNF183 gene
LOC6468622  RNF2232  

RNF183 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/136 SNPs in RNF183 are shown (see all 136)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 9 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1379772901,2
--116058963(+) CCCCCA/GCTGCC 1 -- ds50010--------
rs1839466201,2
--116059006(+) CCTGTG/TTCCAG 1 -- ds50010--------
rs108174751,2
C,F,A,H--116059054(+) GGGGAA/GGGGAA 1 -- ds500119Minor allele frequency- G:0.22NS EA NA CSA WA 2344
rs1494063711,2
--116059071(+) CTCTAC/GCCCAT 1 -- ds50010--------
rs749279881,2
F--116059107(+) TCTGCC/TGGGAG 1 -- ds50011Minor allele frequency- T:0.09WA 118
rs1128378661,2
F--116059207(+) AACTAC/TATGCT 1 -- ds50011Minor allele frequency- T:0.50CSA 2
rs1481712371,2
--116059304(+) TACTCC/TTCTCT 1 -- ds50010--------
rs2012153381,2
--116059390(+) GAACA-/CTTTTA 1 -- ut310--------
rs1901954301,2
--116059444(+) TTACCA/CACAGA 1 -- ut310--------
rs342626871,2
C--116059468(+) CCCAA-/TTTTTT 1 -- ut310--------

HapMap Linkage Disequilibrium report for RNF183 (116059373 - 116065656 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for RNF183:    About this table     
Variant IDTypeSubtypePubMed ID
nsv893744CNV Gain21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for RNF183 gene integrated from 9 sources:
(articles sorted by number of sources associating them with RNF183)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
  3. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
  4. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 138065 HGNC: 28721 AceView: MGC4734 Ensembl:ENSG00000165188 euGenes: HUgn138065
ECgene: RNF183 H-InvDB: RNF183

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for RNF183 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for RNF183 gene:
Search GeneIP for patents involving RNF183

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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 Proteins for RNF183
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 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF183
 inGenious Targeting Laboratory - Custom generated mouse model solutions for RNF183
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Customized:
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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transforming growth factor, beta 1
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