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Aliases for RNF183 Gene

Aliases for RNF183 Gene

  • Ring Finger Protein 183 2 3

External Ids for RNF183 Gene

Previous GeneCards Identifiers for RNF183 Gene

  • GC09M113139
  • GC09M115099
  • GC09M116059
  • GC09M085666

Summaries for RNF183 Gene

GeneCards Summary for RNF183 Gene

RNF183 (Ring Finger Protein 183) is a Protein Coding gene. An important paralog of this gene is RNF223.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF183 Gene

Genomics for RNF183 Gene

Regulatory Elements for RNF183 Gene

Genomic Location for RNF183 Gene

Chromosome:
9
Start:
113,297,093 bp from pter
End:
113,303,376 bp from pter
Size:
6,284 bases
Orientation:
Minus strand

Genomic View for RNF183 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNF183 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF183 Gene

Proteins for RNF183 Gene

  • Protein details for RNF183 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96D59-RN183_HUMAN
    Recommended name:
    RING finger protein 183
    Protein Accession:
    Q96D59

    Protein attributes for RNF183 Gene

    Size:
    192 amino acids
    Molecular mass:
    21617 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RNF183 Gene

Proteomics data for RNF183 Gene at MOPED

Post-translational modifications for RNF183 Gene

No Post-translational modifications

Other Protein References for RNF183 Gene

No data available for DME Specific Peptides for RNF183 Gene

Domains & Families for RNF183 Gene

Gene Families for RNF183 Gene

Protein Domains for RNF183 Gene

Suggested Antigen Peptide Sequences for RNF183 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96D59

UniProtKB/Swiss-Prot:

RN183_HUMAN :
  • Contains 1 RING-type zinc finger.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF183: view

Function for RNF183 Gene

Gene Ontology (GO) - Molecular Function for RNF183 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with RNF183: view

Phenotypes for RNF183 Gene

genes like me logo Genes that share phenotypes with RNF183: view

Animal Model Products

miRNA for RNF183 Gene

miRTarBase miRNAs that target RNF183

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RNF183 Gene

Localization for RNF183 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF183 Gene

Membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for RNF183 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RNF183: view

No data available for Subcellular locations from COMPARTMENTS for RNF183 Gene

Pathways & Interactions for RNF183 Gene

SuperPathways for RNF183 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RNF183 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RNF183 Gene

Drugs & Compounds for RNF183 Gene

No Compound Related Data Available

Transcripts for RNF183 Gene

Unigene Clusters for RNF183 Gene

Ring finger protein 183:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNF183 Gene

No ASD Table

Relevant External Links for RNF183 Gene

GeneLoc Exon Structure for
RNF183
ECgene alternative splicing isoforms for
RNF183

Expression for RNF183 Gene

mRNA expression in normal human tissues for RNF183 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNF183 Gene

This gene is overexpressed in Kidney - Cortex (x8.6), Minor Salivary Gland (x7.6), Testis (x5.8), and Esophagus - Mucosa (x5.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RNF183 Gene



SOURCE GeneReport for Unigene cluster for RNF183 Gene Hs.729641

genes like me logo Genes that share expression patterns with RNF183: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for RNF183 Gene

Orthologs for RNF183 Gene

This gene was present in the common ancestor of mammals.

Orthologs for RNF183 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RNF183 35
  • 85.64 (n)
  • 81.91 (a)
RNF183 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNF183 35
  • 89.12 (n)
  • 89.42 (a)
mouse
(Mus musculus)
Mammalia Rnf183 35
  • 85.79 (n)
  • 88.42 (a)
Rnf183 16
Rnf183 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RNF183 35
  • 98.96 (n)
  • 97.92 (a)
RNF183 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnf183 35
  • 84.39 (n)
  • 86.84 (a)
oppossum
(Monodelphis domestica)
Mammalia RNF183 36
  • 75 (a)
OneToOne
Species with no ortholog for RNF183:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RNF183 Gene

ENSEMBL:
Gene Tree for RNF183 (if available)
TreeFam:
Gene Tree for RNF183 (if available)

Paralogs for RNF183 Gene

Paralogs for RNF183 Gene

genes like me logo Genes that share paralogs with RNF183: view

Variants for RNF183 Gene

Sequence variations from dbSNP and Humsavar for RNF183 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1061943 -- 113,297,402(-) GAGCG(A/G)CCTCC utr-variant-3-prime
rs2296073 -- 113,299,348(+) AGATG(C/T)GAAGA upstream-variant-2KB, intron-variant, utr-variant-5-prime
rs3750531 -- 113,303,076(-) CGGAG(A/G)AGGCG utr-variant-5-prime
rs3750532 -- 113,298,207(-) CGCGA(A/G)GCCTC utr-variant-5-prime
rs3750533 - 113,297,941(-) TGCTC(A/G/T)CCCTG missense, reference

Structural Variations from Database of Genomic Variants (DGV) for RNF183 Gene

Variant ID Type Subtype PubMed ID
nsv893744 CNV Gain 21882294

Variation tolerance for RNF183 Gene

Residual Variation Intolerance Score: 90.78% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.26; 97.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNF183 Gene

HapMap Linkage Disequilibrium report
RNF183

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF183 Gene

Disorders for RNF183 Gene

Relevant External Links for RNF183

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RNF183
genes like me logo Genes that share disorders with RNF183: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF183 Gene

Publications for RNF183 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 67
  4. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 67
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67

Products for RNF183 Gene

Sources for RNF183 Gene

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