RNF183 Gene
protein-coding GIFtS: 43
GCID: GC09M116059
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ring finger protein 183
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Aliases
for RNF183 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ring Finger Protein 1831 2 | | MGC47341 |
Export aliases for RNF183 gene to outside databasesPrevious GC identifers: GC09M113139 GC09M115099 GC09M085666 |
Summaries
for RNF183 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for RNF183 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008470.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RNF183 gene promoter:
GR RP58 p300 HNF-1 FOXJ2 (long isoform) FOXJ2 HNF-1A
Other transcription factors
Search SABiosciences Chromatin IP Primers for RNF183
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF183 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q32 Ensembl cytogenetic band: 9q32 HGNC cytogenetic band: 9q32RNF183 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M116059: view genomic region
(about GC identifiers)
Start:
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116,059,373 bp from pter |
End:
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116,065,656 bp from pter |
Size:
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6,284 bases |
Orientation:
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minus strand |
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Proteins
for RNF183 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RN183_HUMAN, Q96D59 (See
protein sequence)Recommended Name: RING finger protein 183 Size: 192 amino acids; 21675 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)Explore the universe of human proteins at neXtProt for RNF183: NX_Q96D59
RNF183 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_659488.2
ENSEMBL proteins: ENSP00000417176 ENSP00000420740 ENSP00000419454 ENSP00000417943
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
RNF183 for ontologies About GeneDecksing
RNF183 Antibody Products:
Assay Products for RNF183: |
Protein
Domains /
Families
for RNF183 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RNF183 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96D59ProtoNet protein and cluster: Q96D59 1 Blocks protein family: IPB001841 Zn-finger
UniProtKB/Swiss-Prot: RN183_HUMAN, Q96D59Similarity: Contains 1 RING-type zinc finger |
Function
for RNF183 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF183 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF183
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RNF183 (NM_145051) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RNF183 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF183 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF183 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008270 | zinc ion binding |
IEA | -- |
RNF183 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for RNF183:
|
Pathways & Interactions
for RNF183 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNF183
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5/12 Interacting proteins for RNF183 (Q96D592, 3 ENSP000004207404) via UniProtKB, MINT, STRING, and/or I2D (see all 12)About this table
|
Drugs & Compounds
for RNF183 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RNF183
Search CenterWatch for drugs/clinical trials and news about RNF183 / RN183
|
Transcripts
for RNF183 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RNF183 gene: NM_145051.3 Unigene Cluster for RNF183: Ring finger protein 183 Hs.729641 [show with all ESTs]Unigene Representative Sequence: AK0919407 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000441031(uc004bgz.3) ENST00000416588 ENST00000478815(uc022bmd.1)
ENST00000297894(uc004bha.3) ENST00000478493 ENST00000489339 ENST00000443976
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF183 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF183
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RNF183 (NM_145051) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RNF183 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF183 |
Additional cDNA sequence: AK091940.1 BC013036.2 4 DOTS entries: DT.99943120 DT.40282405 DT.95364356 DT.95258548 24/29 AceView cDNA sequences (see all 29): BE463594 AW139879 AA928883 BE501488 NM_145051 AK055759 BC013036 BE326299 AI860474 AI923733 AA337967 AA514593 AX747267 BE468156 AK091940 BF448088 AW614405 BI494082 BI494083 AI889386 BM797555 BE796148 AW183348 AI244282
GeneLoc Exon Structure
|
Expression
for RNF183 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RNF183 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAAGGGCAGA
About this image
See RNF183 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RNF183
SOURCE GeneReport for Unigene cluster: Hs.729641
SABiosciences Custom PCR Arrays for RNF183
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNF183
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RNF183 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNF183 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNF183 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF183 |
Orthologs
for RNF183 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for RNF183 (if available)
TreeFam Gene Tree for RNF183 (if available) |
Paralogs
for RNF183 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RNF183 gene
- RNF2232
RNF183 for paralogs About GeneDecksing
|
Genomic Variants
for RNF183 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RNF183 (116059373 - 116065656 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RNF183: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNF183 |
|
Disorders
/ Diseases
for RNF183 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for RNF183 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RNF183 gene integrated from 9 sources:
(articles sorted by number of sources associating them with RNF183) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
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External Searches for RNF183 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing RNF183 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RNF183 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RNF183 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RNF183 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RNF183 gene:
Search GeneIP for patents involving RNF183
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RNF183 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RNF183 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RNF183 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNF183 | | | OriGene Protein Over-expression Lysate for RNF183 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RNF183 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF183 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF183 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RNF183 | | OriGene Custom Protein Services for RNF183 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RNF183 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNF183 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF183 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNF183 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNF183 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNF183 |
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| | | | Search Tocris compounds for RNF183 |
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 | | | RNF183 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF183 |
|  |  |  | | | | ThermoFisher Antibodies for RNF183 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF183 |
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