Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RNF183 Gene

Aliases for RNF183 Gene

  • Ring Finger Protein 183 2 3 5

External Ids for RNF183 Gene

Previous GeneCards Identifiers for RNF183 Gene

  • GC09M113139
  • GC09M115099
  • GC09M116059
  • GC09M085666

Summaries for RNF183 Gene

GeneCards Summary for RNF183 Gene

RNF183 (Ring Finger Protein 183) is a Protein Coding gene. An important paralog of this gene is RNF223.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF183 Gene

Genomics for RNF183 Gene

Regulatory Elements for RNF183 Gene

Enhancers for RNF183 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G113516 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.7 -218.8 -218830 11.1 HDGF PKNOX1 FOXA2 WRNIP1 SIN3A ZNF143 FOS REST TBX21 GLIS1 C9orf43 RGS3 ALAD RNF183 CDC26 PRPF4 SLC31A2 GC09P113871
GH09G113577 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.9 -276.8 -276848 6.3 HDGF PKNOX1 WRNIP1 SIN3A YY1 ZNF766 GATA2 ZNF143 ZNF207 FOS C9orf43 RGS3 POLE3 ALAD RNF183 GC09P113870 LOC105376221
GH09G113511 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.8 -209.0 -209043 3.1 PKNOX1 YY1 GATA2 ELK1 ZNF207 FOS JUNB TBX21 CBX8 ZNF585B C9orf43 RGS3 ALAD RNF183 CDC26 PRPF4 GC09P113871
GH09G113372 1.6 Ensembl ENCODE dbSUPER 11.3 -74.6 -74624 11.9 HDGF PKNOX1 FOXA2 MLX WRNIP1 ARID4B SIN3A DMAP1 YBX1 ZBTB7B HDHD3 PRPF4 POLE3 C9orf43 RNF183 ALAD CDC26 BSPRY
GH09G113633 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.5 -332.0 -331990 3.1 CTCF FOXA2 HINFP JUN DDX20 ZNF175 ARID4B BACH1 ZNF7 TEAD3 ALAD RNF183 C9orf43 RGS3 PIR57208 ENSG00000282897
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RNF183 on UCSC Golden Path with GeneCards custom track

Genomic Location for RNF183 Gene

Chromosome:
9
Start:
113,297,093 bp from pter
End:
113,303,376 bp from pter
Size:
6,284 bases
Orientation:
Minus strand

Genomic View for RNF183 Gene

Genes around RNF183 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF183 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF183 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF183 Gene

Proteins for RNF183 Gene

  • Protein details for RNF183 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96D59-RN183_HUMAN
    Recommended name:
    RING finger protein 183
    Protein Accession:
    Q96D59

    Protein attributes for RNF183 Gene

    Size:
    192 amino acids
    Molecular mass:
    21617 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RNF183 Gene

Post-translational modifications for RNF183 Gene

No Post-translational modifications

No data available for DME Specific Peptides for RNF183 Gene

Domains & Families for RNF183 Gene

Gene Families for RNF183 Gene

Protein Domains for RNF183 Gene

Suggested Antigen Peptide Sequences for RNF183 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RNF183: view

No data available for UniProtKB/Swiss-Prot for RNF183 Gene

Function for RNF183 Gene

Gene Ontology (GO) - Molecular Function for RNF183 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
GO:0061630 ubiquitin protein ligase activity IDA 26567849
genes like me logo Genes that share ontologies with RNF183: view
genes like me logo Genes that share phenotypes with RNF183: view

Animal Models for RNF183 Gene

MGI Knock Outs for RNF183:

Animal Model Products

CRISPR Products

miRNA for RNF183 Gene

miRTarBase miRNAs that target RNF183

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RNF183 Gene

Localization for RNF183 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF183 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNF183 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
nucleus 3

Gene Ontology (GO) - Cellular Components for RNF183 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 26567849
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RNF183: view

Pathways & Interactions for RNF183 Gene

SuperPathways for RNF183 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RNF183 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IDA 26567849
genes like me logo Genes that share ontologies with RNF183: view

No data available for Pathways by source and SIGNOR curated interactions for RNF183 Gene

Drugs & Compounds for RNF183 Gene

No Compound Related Data Available

Transcripts for RNF183 Gene

Unigene Clusters for RNF183 Gene

Ring finger protein 183:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF183 Gene

No ASD Table

Relevant External Links for RNF183 Gene

GeneLoc Exon Structure for
RNF183
ECgene alternative splicing isoforms for
RNF183

Expression for RNF183 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNF183 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNF183 Gene

This gene is overexpressed in Kidney - Cortex (x8.6), Minor Salivary Gland (x7.6), Testis (x5.8), and Esophagus - Mucosa (x5.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RNF183 Gene



NURSA nuclear receptor signaling pathways regulating expression of RNF183 Gene:

RNF183

SOURCE GeneReport for Unigene cluster for RNF183 Gene:

Hs.729641

Evidence on tissue expression from TISSUES for RNF183 Gene

  • Lung(4)
genes like me logo Genes that share expression patterns with RNF183: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNF183 Gene

Orthologs for RNF183 Gene

This gene was present in the common ancestor of mammals.

Orthologs for RNF183 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNF183 34 35
  • 98.96 (n)
dog
(Canis familiaris)
Mammalia RNF183 34
  • 89.12 (n)
mouse
(Mus musculus)
Mammalia Rnf183 34 16 35
  • 85.79 (n)
cow
(Bos Taurus)
Mammalia RNF183 34 35
  • 85.64 (n)
rat
(Rattus norvegicus)
Mammalia Rnf183 34
  • 84.39 (n)
oppossum
(Monodelphis domestica)
Mammalia RNF183 35
  • 75 (a)
OneToOne
Species where no ortholog for RNF183 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RNF183 Gene

ENSEMBL:
Gene Tree for RNF183 (if available)
TreeFam:
Gene Tree for RNF183 (if available)

Paralogs for RNF183 Gene

Paralogs for RNF183 Gene

genes like me logo Genes that share paralogs with RNF183: view

Variants for RNF183 Gene

Sequence variations from dbSNP and Humsavar for RNF183 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000225968 -- 113,304,003(+) GTAAC(C/T)CCCAC upstream-variant-2KB
rs1000528155 -- 113,304,899(+) GATGA(G/T)GTATT upstream-variant-2KB
rs1000564960 -- 113,302,527(+) TGCTA(A/T)GATCT intron-variant
rs1000778934 -- 113,302,190(+) TCAGA(C/T)CTACC intron-variant, utr-variant-5-prime
rs1001305469 -- 113,299,625(+) AGATC(C/T)TAGAG upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for RNF183 Gene

Variant ID Type Subtype PubMed ID
esv3621540 CNV gain 21293372

Variation tolerance for RNF183 Gene

Residual Variation Intolerance Score: 90.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.26; 97.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNF183 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNF183

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF183 Gene

Disorders for RNF183 Gene

Relevant External Links for RNF183

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RNF183

No disorders were found for RNF183 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF183 Gene

Publications for RNF183 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. E3 Ubiquitin ligase RNF183 Is a Novel Regulator in Inflammatory Bowel Disease. (PMID: 26818663) Yu Q. … Chen M. (J Crohns Colitis 2016) 3 64
  4. Comprehensive functional characterization of cancer-testis antigens defines obligate participation in multiple hallmarks of cancer. (PMID: 26567849) Maxfield K.E. … Whitehurst A.W. (Nat Commun 2015) 3 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for RNF183 Gene

Sources for RNF183 Gene

Content
Loading form....