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Aliases for RNF182 Gene

Aliases for RNF182 Gene

  • Ring Finger Protein 182 2 3
  • RING Finger Protein 182 4
  • EC 6.3.2.- 4

External Ids for RNF182 Gene

Previous GeneCards Identifiers for RNF182 Gene

  • GC06P014034

Summaries for RNF182 Gene

GeneCards Summary for RNF182 Gene

RNF182 (Ring Finger Protein 182) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ubiquitin-protein transferase activity.

UniProtKB/Swiss-Prot for RNF182 Gene

  • E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C and targets it to degradation via the ubiquitin-proteasome pathway.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF182 Gene

Genomics for RNF182 Gene

Regulatory Elements for RNF182 Gene

Genomic Location for RNF182 Gene

Start:
13,924,446 bp from pter
End:
13,980,302 bp from pter
Size:
55,857 bases
Orientation:
Plus strand

Genomic View for RNF182 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNF182 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF182 Gene

Proteins for RNF182 Gene

  • Protein details for RNF182 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N6D2-RN182_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase RNF182
    Protein Accession:
    Q8N6D2
    Secondary Accessions:
    • B2RDG2
    • Q8NBG3

    Protein attributes for RNF182 Gene

    Size:
    247 amino acids
    Molecular mass:
    27402 Da
    Quaternary structure:
    • Interacts with ATP6V0C.

neXtProt entry for RNF182 Gene

Proteomics data for RNF182 Gene at MOPED

Post-translational modifications for RNF182 Gene

No Post-translational modifications

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for RNF182

No data available for DME Specific Peptides for RNF182 Gene

Domains for RNF182 Gene

Gene Families for RNF182 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for RNF182 Gene

Suggested Antigen Peptide Sequences for RNF182 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N6D2

UniProtKB/Swiss-Prot:

RN182_HUMAN :
  • Q8N6D2
Domain:
  • The RING-type zinc finger domain is required for E3 ligase activity.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF182: view

Function for RNF182 Gene

Molecular function for RNF182 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C and targets it to degradation via the ubiquitin-proteasome pathway.

Enzyme Numbers (IUBMB) for RNF182 Gene

Gene Ontology (GO) - Molecular Function for RNF182 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 18298843
GO:0005515 protein binding IPI 18298843
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with RNF182: view

Phenotypes for RNF182 Gene

GenomeRNAi human phenotypes for RNF182:
genes like me logo Genes that share phenotypes with RNF182: view

miRNA for RNF182 Gene

miRTarBase miRNAs that target RNF182

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNF182

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for RNF182 Gene

Localization for RNF182 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF182 Gene

Membrane; Multi-pass membrane protein. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNF182 Gene COMPARTMENTS Subcellular localization image for RNF182 gene
Compartment Confidence
nucleus 3
cytosol 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RNF182 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 18298843
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RNF182: view

Pathways for RNF182 Gene

genes like me logo Genes that share pathways with RNF182: view

UniProtKB/Swiss-Prot Q8N6D2-RN182_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for RNF182 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with RNF182: view

Transcripts for RNF182 Gene

Unigene Clusters for RNF182 Gene

Ring finger protein 182:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNF182

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF182 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c
SP1:
SP2: - - - -
SP3: -
SP4: -

Relevant External Links for RNF182 Gene

GeneLoc Exon Structure for
RNF182
ECgene alternative splicing isoforms for
RNF182

Expression for RNF182 Gene

mRNA expression in normal human tissues for RNF182 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNF182 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (5.8), Brain - Cerebellum (5.5), Brain - Anterior cingulate cortex (BA24) (4.8), Brain - Frontal Cortex (BA9) (4.8), Brain - Hippocampus (4.7), and Brain - Cortex (4.1).

Protein differential expression in normal tissues for RNF182 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RNF182 Gene

SOURCE GeneReport for Unigene cluster for RNF182 Gene Hs.111164

mRNA Expression by UniProt/SwissProt for RNF182 Gene

Q8N6D2-RN182_HUMAN
Tissue specificity: Up-regulated in neuronal cells subjected to cell death-inducing injuries, such as oxygen and glucose deprivation (at protein level). Could be up-regulated in Alzheimer disease brains.
genes like me logo Genes that share expressions with RNF182: view

Expression partners for RNF182 Gene

In Situ Assay Products

Orthologs for RNF182 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNF182 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RNF182 35
  • 83.81 (n)
  • 93.52 (a)
RNF182 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNF182 35
  • 91.5 (n)
  • 97.98 (a)
RNF182 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnf182 35
  • 88.53 (n)
  • 98.38 (a)
Rnf182 16
Rnf182 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RNF182 35
  • 99.6 (n)
  • 100 (a)
RNF182 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnf182 35
  • 87.99 (n)
  • 97.57 (a)
oppossum
(Monodelphis domestica)
Mammalia RNF182 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RNF182 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves RNF182 35
  • 82.1 (n)
  • 90.98 (a)
RNF182 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RNF182 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf182 35
  • 76.72 (n)
  • 82.23 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.17893 35
zebrafish
(Danio rerio)
Actinopterygii rnf182 35
  • 57.84 (n)
  • 56.3 (a)
rnf182 36
  • 53 (a)
OneToOne
Species with no ortholog for RNF182:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF182 Gene

ENSEMBL:
Gene Tree for RNF182 (if available)
TreeFam:
Gene Tree for RNF182 (if available)

Paralogs for RNF182 Gene

Selected SIMAP similar genes for RNF182 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for RNF182 Gene

genes like me logo Genes that share paralogs with RNF182: view

No data available for Paralogs for RNF182 Gene

Variants for RNF182 Gene

Sequence variations from dbSNP and Humsavar for RNF182 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs183969 -- 13,973,018(+) cagga(A/G)ggagg intron-variant
rs184898 -- 13,939,800(+) agcct(C/T)ccaaa intron-variant
rs280143 -- 13,929,271(+) ATTGT(A/G)TTTGA intron-variant
rs280144 -- 13,930,044(+) AAGAA(C/T)ATagt intron-variant
rs280145 -- 13,934,257(+) CACTC(C/G)TCACC intron-variant

Relevant External Links for RNF182 Gene

HapMap Linkage Disequilibrium report
RNF182

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RNF182 Gene

Disorders for RNF182 Gene

Relevant External Links for RNF182

Genetic Association Database (GAD)
RNF182

No disorders were found for RNF182 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for RNF182 Gene

Publications for RNF182 Gene

  1. A novel brain-enriched E3 ubiquitin ligase RNF182 is up regulated in the brains of Alzheimer's patients and targets ATP6V0C for degradation. (PMID: 18298843) Liu Q.Y. … Liu R. (Mol. Neurodegener. 2008) 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for RNF182 Gene

Sources for RNF182 Gene

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