Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RNF182 Gene

protein-coding   GIFtS: 50
GCID: GC06P013924

Ring Finger Protein 182

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ring Finger Protein 1821 2 3
E3 Ubiquitin-Protein Ligase RNF1822
EC 6.3.2.-3

External Ids:    HGNC: 285221   Entrez Gene: 2216872   Ensembl: ENSG000001805377   UniProtKB: Q8N6D23   

Export aliases for RNF182 gene to outside databases

Previous GC identifer: GC06P014034


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RNF182 Gene: 
RNF182 (ring finger protein 182) is a protein-coding gene. Diseases associated with RNF182 include alzheimer's disease, and neuronitis, and among its related super-pathways are Class I MHC mediated antigen processing & presentation and Immune System. GO annotations related to this gene include ubiquitin-protein ligase activity and zinc ion binding.

UniProtKB/Swiss-Prot: RN182_HUMAN, Q8N6D2
Function: E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C and targets it to degradation
via the ubiquitin-proteasome pathway




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RNF182 gene promoter:
         c-Fos   AP-1   Olf-1   CUTL1   NF-AT   NF-AT4   NF-AT2   NF-AT3   c-Jun   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNF182 promoter sequence
   Search SABiosciences Chromatin IP Primers for RNF182

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF182


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p23   Ensembl cytogenetic band:  6p23   HGNC cytogenetic band: 6p23

RNF182 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF182 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P013924:  view genomic region     (about GC identifiers)

Start:
13,924,677 bp from pter      End:
13,980,533 bp from pter
Size:
55,857 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RN182_HUMAN, Q8N6D2 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase RNF182  
Size: 247 amino acids; 27402 Da
Subunit: Interacts with ATP6V0C
Subcellular location: Membrane; Multi-pass membrane protein (Potential). Cytoplasm
Secondary accessions: B2RDG2 Q8NBG3

Explore the universe of human proteins at neXtProt for RNF182: NX_Q8N6D2

Explore proteomics data for RNF182 at MOPED 

RNF182 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

RNF182 Protein Expression

REFSEQ proteins (4 alternative transcripts): 
NP_001158504.1  NP_001158505.1  NP_001158506.1  NP_689950.1  

ENSEMBL proteins: 
 ENSP00000417500   ENSP00000420465   ENSP00000419329   ENSP00000417514   ENSP00000418717  
 ENSP00000443228   ENSP00000442021   ENSP00000441271  
Reactome Protein details: Q8N6D2
Human Recombinant Protein Products for RNF182: 
Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate for RNF182
OriGene Custom MassSpec 
OriGene Custom Protein Services for RNF182
GenScript Custom Purified and Recombinant Proteins Services for RNF182
Novus Biologicals RNF182 Proteins
Novus Biologicals RNF182 Lysates
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates 
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for RNF182 

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005737cytoplasm IDA18298843
GO:0016021integral to membrane IEA--
GO:0043231intracellular membrane-bounded organelle IDA--

RNF182 for ontologies           About GeneDecksing



RNF182 Antibody Products: 
Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse R&D Systems for Antibodies
Browse OriGene Antibodies
OriGene Custom Antibody Services for RNF182
GenScript Custom Superior Antibodies Services for RNF182
Novus Biologicals RNF182 Antibodies
Abcam antibodies for RNF182
Cloud-Clone Corp. Antibodies for RNF182 
Search ThermoFisher Antibodies for RNF182
LSBio Antibodies in human, mouse, rat for RNF182 

Assay Products for RNF182: 
Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for RNF182
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for RNF182
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for RNF182 
Cloud-Clone Corp. CLIAs for RNF182


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
RNF: RING-type (C3HC4) zinc fingers

4 InterPro protein domains:
 IPR017907 Znf_RING_CS
 IPR001841 Znf_RING
 IPR027370 zf-RING_LisH
 IPR013083 Znf_RING/FYVE/PHD

Graphical View of Domain Structure for InterPro Entry Q8N6D2

ProtoNet protein and cluster: Q8N6D2

1 Blocks protein domain: IPB001841 Zn-finger

UniProtKB/Swiss-Prot: RN182_HUMAN, Q8N6D2
Domain: The RING-type zinc finger domain is required for E3 ligase activity (By similarity)
Similarity: Contains 1 RING-type zinc finger


RNF182 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: RN182_HUMAN, Q8N6D2
Function: E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C and targets it to degradation
via the ubiquitin-proteasome pathway

     Enzyme Number (IUBMB): EC 6.3.2.-1

     Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004842ubiquitin-protein ligase activity IDA18298843
GO:0005515protein binding IPI18298843
GO:0008270zinc ion binding IEA--
GO:0046872metal ion binding ----
     
RNF182 for ontologies           About GeneDecksing


Phenotypes:
     2 GenomeRNAi human phenotypes for RNF182:
 Cell cycle / mitosis defect  Elongated cells 

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for RNF182 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RNF182

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RNF182 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RNF182 

miRNA
Products:
    
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RNF182
8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate RNF182 (see all 20):
hsa-miR-875-3p hsa-miR-181c hsa-miR-330-5p hsa-miR-4272 hsa-miR-128 hsa-miR-605 hsa-miR-410 hsa-miR-326
SwitchGear 3'UTR luciferase reporter plasmidRNF182 3' UTR sequence
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for RNF182
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNF182

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for RNF182
Sirion Biotech Customized adenovirus for overexpression of RNF182

Clone
Products:
     
Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene clones in human, mouse for RNF182 (see all 20)
OriGene ORF clones in mouse, rat for RNF182
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 4): RNF182 (NM_152737)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNF182
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF182
Sirion Biotech Customized lentivirus for stable overexpression of RNF182 
                     Customized lentivirus expression plasmids for stable overexpression of RNF182 

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for RNF182
Search LifeMap BioReagents cell lines for RNF182
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF182


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for RNF182 About                                                                                                See pathways by source

SuperPathContained pathways About
1Antigen processing: Ubiquitination & Proteasome degradation
Antigen processing: Ubiquitination & Proteasome degradation0.83
Class I MHC mediated antigen processing & presentation0.83
2Immune System
Immune System0.56
Adaptive Immune System0.56

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


4        Reactome Pathways for RNF182
    Antigen processing: Ubiquitination & Proteasome degradation
Adaptive Immune System
Class I MHC mediated antigen processing & presentation
Immune System


UniProtKB/Swiss-Prot: RN182_HUMAN, Q8N6D2
Pathway: Protein modification; protein ubiquitination


RNF182 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNF182

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

4 Interacting proteins for RNF182 (Q8N6D23 ENSP000004204654) via UniProtKB, MINT, STRING, and/or I2D

InteractantInteraction Details
GeneCardExternal ID(s)
UBE2NP610883, ENSP000003161764I2D: score=2 STRING: ENSP00000316176
ATP6V0CENSP000003297574STRING: ENSP00000329757
UBCENSP000003448184STRING: ENSP00000344818
ELAVL1ENSP000003852694STRING: ENSP00000385269
About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016567protein ubiquitination IDA18298843

RNF182 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RNF182 (RN182)

Search CenterWatch for drugs/clinical trials and news about RNF182 / RN182

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RNF182 gene (4 alternative transcripts): 
NM_001165032.1  NM_001165033.1  NM_001165034.1  NM_152737.3  

Unigene Cluster for RNF182:

Ring finger protein 182
Hs.111164  [show with all ESTs]
Unigene Representative Sequence: NM_001165032
8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000488763 ENST00000488300(uc003nbe.3 uc003nbf.3) ENST00000420478
ENST00000471906 ENST00000423553 ENST00000537663(uc021ylw.1) ENST00000544682(uc021ylx.1)
ENST00000537388(uc003nbg.3)

miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RNF182
8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate RNF182 (see all 20):
hsa-miR-875-3p hsa-miR-181c hsa-miR-330-5p hsa-miR-4272 hsa-miR-128 hsa-miR-605 hsa-miR-410 hsa-miR-326
SwitchGear 3'UTR luciferase reporter plasmidRNF182 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for RNF182
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNF182
Clone
Products:
     
OriGene clones in human, mouse for RNF182 (see all 20)
OriGene ORF clones in mouse, rat for RNF182
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 4): RNF182 (NM_152737)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNF182
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF182
Sirion Biotech Customized lentivirus for stable overexpression of RNF182 
                     Customized lentivirus expression plasmids for stable overexpression of RNF182 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for RNF182
OriGene qSTAR qPCR primer pairs in human, mouse for RNF182
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RNF182
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNF182
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNF182

Additional mRNA sequence: 

AK090576.1 AK098091.1 AK315528.1 BC030666.1 BC050030.1 

6 DOTS entries:

DT.100748263  DT.401959  DT.95265259  DT.430538  DT.121394263  DT.121394264 

24/42 AceView cDNA sequences (see all 42):

BE504513 AI743910 AA599692 BU678155 BF196765 AI361053 BU688477 AI370991 
NM_152737 BM546508 AX746519 BI552264 AI884906 BQ187566 AK090576 BC050030 
AK098091 AW731636 AI912104 AW054717 BU945333 BC030666 BF129987 BI544248 

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for RNF182    About this scheme

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c
SP1:                                                      
SP2:        -     -     -     -                           
SP3:                          -                           
SP4:                          -                           


ECgene alternative splicing isoforms for RNF182

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RNF182 expression in normal human tissues (normalized intensities)      RNF182 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CTATTGAATG
RNF182 Expression
About this image


RNF182 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/8 selected tissues (see all 8) fully expand
 
 Inner Cell Mass (Early Embryonic Tissues)
         Line H7 (WA07)
 
 Gonad
         Primordial Germ Cells Allantois
 
 Pancreas (Endocrine System)
         Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...
 
 Endothelium (Cardiovascular System)
         Umbilical cord blood-derived endothelial progenitor cells
 
 Umbilical Cord (Extraembryonic Tissues)
         Umbilical cord blood-derived endothelial progenitor cells

See RNF182 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RNF182

SOURCE GeneReport for Unigene cluster: Hs.111164

UniProtKB/Swiss-Prot: RN182_HUMAN, Q8N6D2
Tissue specificity: Up-regulated in neuronal cells subjected to cell death-inducing injuries, such as oxygen and
glucose deprivation (at protein level). Could be up-regulated in Alzheimer disease brains

    SABiosciences Custom PCR Arrays for RNF182
Primer
Products:
OriGene qPCR primer pairs and template standards for RNF182
OriGene qSTAR qPCR primer pairs in human, mouse for RNF182
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RNF182
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNF182
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNF182
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF182

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for RNF182 gene from 5/11 species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Rnf1821 , 5 ring finger protein 1821, 5 88.53(n)1
98.38(a)1
  13 (21.60 cM)5
3282341  NM_183204.41  NP_899027.11 
 436157105 
chicken
(Gallus gallus)
Aves RNF1821 ring finger protein 182 82.1(n)
90.98(a)
  771221  XM_001234513.1  XP_001234514.1 
lizard
(Anolis carolinensis)
Reptilia RNF1826
--
(see all 3)
--
90(a)
48(a)
(see all 3)
1 ↔ 1
possible ortholog
(see all 3)
4(57230499-57231239)
GL343483.1(86650-98304)
African clawed frog
(Xenopus laevis)
Amphibia Xl.178932 Xenopus laevis transcribed sequence 84.97(n)    BG812190.1 
zebrafish
(Danio rerio)
Actinopterygii zgc:1534141 zgc:153414 58.12(n)
56.72(a)
  751631  NM_001045351.1  NP_001038816.1 


ENSEMBL Gene Tree for RNF182 (if available)
TreeFam Gene Tree for RNF182 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for RNF182 gene
1 SIMAP similar gene for RNF182 using alignment to 5 protein entries:     RN182_HUMAN (see all proteins):
RNF152

RNF182 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for RNF182
PGOHUM00000240530


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/1074 SNPs in RNF182 are shown (see all 1074)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 6 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0359594
A colorectal cancer sample4--see VAR_0359592 V A mis40--------
VAR_0359604
A colorectal cancer sample4--see VAR_0359602 P L mis40--------
rs1427513821,2
--13922684(+) TATTGA/TTCCAA 1 -- us2k10--------
rs1510365271,2
--13922813(+) AAATTC/GATTAT 1 -- us2k10--------
rs761588771,2
F--13922868(+) TGTATC/TCACAC 1 -- us2k11Minor allele frequency- T:0.03WA 118
rs1409530581,2
--13923147(+) ACAACA/GTGGAC 3 -- us2k10--------
rs1148346791,2
C,F--13923360(+) TACATC/TGTAAG 3 -- us2k11Minor allele frequency- T:0.02NA 120
rs592477691,2
F--13923919(+) AGGAAC/AAAACT 4 -- us2k11Minor allele frequency- A:0.04WA 118
rs1821405451,2
--13923947(+) TGAAAC/TAGATC 4 -- us2k10--------
rs4115011,2
C,F,A,H--13923976(+) ATATAT/GGTGTA 4 -- us2k123Minor allele frequency- G:0.14NS EA NA WA CSA 1329

HapMap Linkage Disequilibrium report for RNF182 (13924677 - 13980533 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for RNF182: --
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing RNF182
DNA2.0 Custom Variant and Variant Library Synthesis for RNF182

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
2 diseases for RNF182:    About MalaCards
alzheimer's disease    neuronitis


RNF182 for disorders           About GeneDecksing


Congresses - knowledge worth sharing:  
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
Genetic Association Database (GAD): RNF182

Export disorders for RNF182 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for RNF182 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with RNF182)
    Utopia: connect your pdf to the dynamic
world of online information

  1. A novel brain-enriched E3 ubiquitin ligase RNF182 is up regulated in the brains of Alzheimer's patients and targets ATP6V0C for degr adation. (PubMed id 18298843)1, 2 Liu Q.Y....Liu R. (2008)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
  5. Susceptibility loci associated with specific and share d subtypes of lymphoid malignancies. (PubMed id 23349640)1 Vijai J....Offit K. (2013)
  6. Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population. (PubMed id 22446963)4 Okada Y....Yamamoto K. (2012)
  7. Genome-wide association identifies the ABO blood grou p as a major locus associated with serum levels of soluble E-selectin. (PubMed id 19729612)4 Paterson A.D....Bull S.B. (2009)
  8. A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. (PubMed id 19690564)1 van Wijk S.J....Timmers H.T. (2009)
  9. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
  10. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 221687 HGNC: 28522 AceView: MGC33993 Ensembl:ENSG00000180537 euGenes: HUgn221687
ECgene: RNF182 H-InvDB: RNF182

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for RNF182 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for RNF182 gene:
Search GeneIP for patents involving RNF182

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
 EMD Millipore Custom Antibody & Bulk Services
 EMD Millipore Preclinical / Clinical Development Services
 EMD Millipore Immunoassay Services
 EMD Millipore Target Screening & Profiling Services

  
 Browse Antibodies   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
 Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
 Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for RNF182  
 OriGene qPCR primer pairs and template standards for RNF182   OriGene Protein Over-expression Lysate for RNF182  
 OriGene Custom Mass Spec   OriGene clones in human, mouse for RNF182  
 OriGene qSTAR qPCR primer pairs in human, mouse for RNF182   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
 OriGene ORF clones in mouse, rat for RNF182   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for RNF182   OriGene Custom Protein Services for RNF182  

 
 
 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RNF182
 QIAGEN SeqTarget long-range PCR primers for resequencing RNF182
 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF182
 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNF182
 QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNF182
 QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNF182
 GenScript Custom Purified and Recombinant Proteins Services for RNF182 GenScript cDNA clones with any tag delivered in your preferred vector for RNF182
 GenScript Custom Assay Services for RNF182 GenScript Custom Superior Antibodies Services for RNF182
 GenScript Custom overexpressing Cell Line Services for RNF182 CloneReady with Over 120,000 Genes
 Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
 Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
 Custom Peptide Services
 Search for Antibodies & Assays

 Regulatory tfbs in RNF182 promoter
 Search Chromatin IP Primers for RNF182
 RT2 qPCR Primer Assay in human, mouse, rat RNF182
 Search GNC Networks for RNF182
 SABiosciences Custom PCR Arrays for RNF182
 Search Tocris compounds for RNF182 (RN182)
 Browse Sino Biological Proteins and Antibodies
 Browse Sino Biological Cell Lysates
 Browse Sino Biological cDNA Clones
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
 Novus Tissue Slides
 RNF182 antibodies
 RNF182 proteins
 RNF182 lysates
 Antibodies for RNF182
 See all of Abcam's Antibodies, Kits and Proteins for RNF182
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins




 Proteins for RNF182
 Antibodies for RNF182
 ELISAs for RNF182
 CLIAs for RNF182
 Search LifeMap BioReagents cell lines for RNF182
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF182
 SwitchGear 3'UTR luciferase reporter plasmids for RNF182
 SwitchGear Promoter luciferase reporter plasmids for RNF182
 Search ThermoFisher Antibodies for RNF182
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF182
 inGenious Targeting Laboratory - Custom generated mouse model solutions for RNF182
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RNF182
Customized:
 lentivirus for stable overexpression of RNF182
 lentivirus expression plasmids for stable overexpression of RNF182
 adenovirus for overexpression of RNF182
 LSBio Antibodies in human, mouse, rat for RNF182
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
       
GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

View Random Gene

Category
(GIFtS: 73)
transforming growth factor, beta 1
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      RNF182 gene at Home site.
hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4