Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RNF182 Gene

protein-coding GIFtS: 48
GCID: GC06P013924

ring finger protein 182

Explore 2 diseases affiliated with
RNF182 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ring Finger Protein 182¹ ² ³
MGC33993¹
E3 Ubiquitin-Protein Ligase RNF182²
EC 6.3.2.-³

External Ids:	HGNC: 28522¹	Entrez Gene: 221687²	Ensembl: ENSG00000180537⁷	UniProtKB: Q8N6D2³

Export aliases for RNF182 gene to outside databases

Previous GC identifer: GC06P014034

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: RN182_HUMAN, Q8N6D2

Function: E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C and targets it to degradation via the

ubiquitin-proteasome pathway

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_007592.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RNF182 gene promoter:
c-Fos AP-1 Olf-1 CUTL1 NF-AT NF-AT4 NF-AT2 NF-AT3 c-Jun NF-AT1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RNF182 promoter sequence

Search SABiosciences Chromatin IP Primers for RNF182

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF182

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p23 Ensembl cytogenetic band: 6p23 HGNC cytogenetic band: 6p23

RNF182 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF182 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P013924: view genomic region (about GC identifiers)

Start:	13,924,677 bp from pter	End:	13,980,533 bp from pter
Size:	55,857 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RN182_HUMAN, Q8N6D2 (See protein sequence)

Recommended Name: E3 ubiquitin-protein ligase RNF182

Size: 247 amino acids; 27402 Da

Subunit: Interacts with ATP6V0C

Subcellular location: Membrane; Multi-pass membrane protein (Potential). Cytoplasm

Secondary accessions: B2RDG2 Q8NBG3

Explore the universe of human proteins at neXtProt for RNF182: NX_Q8N6D2

RNF182 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001158504.1 NP_001158505.1 NP_001158506.1 NP_689950.1

ENSEMBL proteins:

ENSP00000417500 ENSP00000420465 ENSP00000419329 ENSP00000417514 ENSP00000418717

ENSP00000443228 ENSP00000442021 ENSP00000441271

Reactome Protein details: Q8N6D2
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate (see all 4): RNF182 OriGene Custom Protein Services for RNF182
	GenScript Custom Purified and Recombinant Proteins Services for RNF182
	Novus Biologicals RNF182 Proteins Novus Biologicals RNF182 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for RNF182

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	18298843
GO:0016021	integral to membrane	IEA	--
GO:0043231	intracellular membrane-bounded organelle	IDA	--

RNF182 for ontologies About GeneDecksing

RNF182 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for RNF182
	GenScript Custom Superior Antibodies Services for RNF182
	Novus Biologicals RNF182 Antibodies
	Search for Antibodies for RNF182 at Abcam
	Uscn Antibodies for RNF182
	Search ThermoFisher Antibodies for RNF182

Assay Products for RNF182:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for RNF182
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for RNF182

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RNF182 for domains About GeneDecksing

3 InterPro domains/families:

IPR017907 Znf_RING_CS

IPR001841 Znf_RING

IPR013083 Znf_RING/FYVE/PHD

Graphical View of Domain Structure for InterPro Entry Q8N6D2

ProtoNet protein and cluster: Q8N6D2

1 Blocks protein family: IPB001841 Zn-finger

UniProtKB/Swiss-Prot: RN182_HUMAN, Q8N6D2

Domain: The RING-type zinc finger domain is required for E3 ligase activity (By similarity)

Similarity: Contains 1 RING-type zinc finger

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: RN182_HUMAN, Q8N6D2

Function: E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C and targets it to degradation via the

ubiquitin-proteasome pathway

Enzyme Number (IUBMB): EC 6.3.2.-¹

miRNA Products:		OriGene 3'-UTR Clone (see all 4): RNF182 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RNF182
		8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate RNF182 (see all 20):
		hsa-miR-875-3p hsa-miR-181c hsa-miR-330-5p hsa-miR-4272 hsa-miR-128 hsa-miR-605 hsa-miR-410 hsa-miR-326

		SwitchGear 3'UTR luciferase reporter plasmid: RNF182 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RNF182 (see all 7) OriGene shRNA RFP: RNF182 Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNF182

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for RNF182

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF182 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF182 (see all 5) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): RNF182 (NM_152737)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNF182
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF182

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for RNF182
		Search LifeMap BioReagents cell lines for RNF182

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF182

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004842	ubiquitin-protein ligase activity	IDA	18298843
GO:0005515	protein binding	IPI	18298843
GO:0008270	zinc ion binding	IEA	--

RNF182 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for RNF182:

Cell cycle / mitosis defect

Elongated cells

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Antigen processing: Ubiquitination & Proteasome degradation

	Antigen processing: Ubiquitination & Proteasome degradation	1.00			Polyubiquitination of substrate	0.75
	Class I MHC mediated antigen processing & presentation	0.83

Immune System

Immune System

1.00

Adaptive Immune System

0.59

Pathway sources
See GeneCards unified pathways
Show all pathways

5 Reactome Pathways for RNF182

	Antigen processing: Ubiquitination & Proteasome degradation
	Polyubiquitination of substrate
	Adaptive Immune System
	Class I MHC mediated antigen processing & presentation
	Immune System

UniProtKB/Swiss-Prot: RN182_HUMAN, Q8N6D2

Pathway: Protein modification; protein ubiquitination

RNF182 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for RNF182

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

4 Interacting proteins for RNF182 (Q8N6D2³ ENSP00000420465⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UBE2N	P61088³, ENSP00000316176⁴	I2D: score=2 STRING: ENSP00000316176
ATP6V0C	ENSP00000329757⁴	STRING: ENSP00000329757
UBC	ENSP00000344818⁴	STRING: ENSP00000344818
ELAVL1	ENSP00000385269⁴	STRING: ENSP00000385269

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016567	protein ubiquitination	IDA	18298843

RNF182 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RNF182
Search CenterWatch for drugs/clinical trials and news about RNF182 / RN182

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RNF182 gene (4 alternative transcripts):

NM_001165032.1 NM_001165033.1 NM_001165034.1 NM_152737.3

Unigene Cluster for RNF182:

Ring finger protein 182

Hs.111164 [show with all ESTs]

Unigene Representative Sequence: NM_001165032

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000488763 ENST00000488300(uc003nbe.3 uc003nbf.3) ENST00000420478

ENST00000471906 ENST00000423553 ENST00000537663(uc021ylw.1) ENST00000544682(uc021ylx.1)

ENST00000537388(uc003nbg.3)

miRNA Products:		OriGene 3'-UTR Clone (see all 4): RNF182 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RNF182
		8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate RNF182 (see all 20):
		hsa-miR-875-3p hsa-miR-181c hsa-miR-330-5p hsa-miR-4272 hsa-miR-128 hsa-miR-605 hsa-miR-410 hsa-miR-326

		SwitchGear 3'UTR luciferase reporter plasmid: RNF182 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RNF182 (see all 7) OriGene shRNA RFP: RNF182 Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNF182

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF182 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF182 (see all 5) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): RNF182 (NM_152737)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNF182
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF182

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNF182 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat RNF182
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNF182
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNF182

Additional cDNA sequence:

AK090576.1 AK098091.1 AK315528.1 BC030666.1 BC050030.1

6 DOTS entries:

DT.100748263 DT.401959 DT.95265259 DT.430538 DT.121394263 DT.121394264

24/42 AceView cDNA sequences (see all 42):

BU688477 AI361053 AA599692 BF196765 AI743910 BU678155 AI370991 BE504513

NM_152737 AK098091 BM546508 BC030666 AW731636 BC050030 BU945333 AI884906

AX746519 BQ187566 BI552264 AK090576 AW054717 AI912104 BF129987 BI544248

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for RNF182 About this scheme

ExUns:	1	^	2a	·	2b	·	2c	^	3	^	4	^	5a	·	5b	·	5c
SP1:
SP2:			-		-		-		-
SP3:									-
SP4:									-

ECgene alternative splicing isoforms for RNF182

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RNF182 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTATTGAATG

About this image

RNF182 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Adipose

Interscapular Brown Adipose Depot

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

PureStem™ progenitor U31 (Embryonic Progenitor Cell)

Posterior foregut-like cells (A scalable, suspensi...)

See RNF182 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RNF182

SOURCE GeneReport for Unigene cluster: Hs.111164

UniProtKB/Swiss-Prot: RN182_HUMAN, Q8N6D2

Tissue specificity: Up-regulated in neuronal cells subjected to cell death-inducing injuries, such as oxygen and

glucose deprivation (at protein level). Could be up-regulated in Alzheimer disease brains

SABiosciences Custom PCR Arrays for RNF182

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNF182 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat RNF182
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNF182
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNF182

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF182

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for RNF182 gene from 5/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Rnf182^{1 , 5}	ring finger protein 182^{1, 5}	88.53(n)¹ 98.38(a)¹		13 (21.60 cM)⁵ 328234¹ NM_183204.4¹ NP_899027.1¹ 43615710⁵
chicken (Gallus gallus)	Aves	RNF182¹	ring finger protein 182	82.1(n) 90.98(a)		771221 XM_001234513.1 XP_001234514.1
lizard (Anolis carolinensis)	Reptilia	RNF182⁶ --	--	90(a) 32(a)	1 ↔ 1 possible ortholog	4(57230499-57231239) GL343741.1(223723-224535)
African clawed frog (Xenopus laevis)	Amphibia	Xl.17893²	Xenopus laevis transcribed sequence	84.97(n)		BG812190.1
zebrafish (Danio rerio)	Actinopterygii	zgc:153414¹	zgc:153414	58.12(n) 56.72(a)		751631 NM_001045351.1 NP_001038816.1

ENSEMBL Gene Tree for RNF182 (if available)
TreeFam Gene Tree for RNF182 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RNF182 gene

RNF152²

1 SIMAP similar gene for RNF182 using alignment to 5 protein entries: RN182_HUMAN (see all proteins):

RNF152

RNF182 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for RNF182
PGOHUM00000240530

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs142751382^1,2		--	13922684(+)	`TATTGA/TTCCAA`	1	--	us2k¹		0	--	--	--	--
rs151036527^1,2		--	13922813(+)	`AAATTC/GATTAT`	1	--	us2k¹		0	--	--	--	--
rs76158877^1,2	F,	--	13922868(+)	`TGTATC/TCACAC`	1	--	us2k¹		1		WA	118
rs140953058^1,2		--	13923147(+)	`ACAACA/GTGGAC`	3	--	us2k¹		0	--	--	--	--
rs114834679^1,2	C,F,	--	13923360(+)	`TACATC/TGTAAG`	3	--	us2k¹		1		NA	120
rs59247769^1,2	F,	--	13923919(+)	`AGGAAC/AAAACT`	4	--	us2k¹		1		WA	118
rs182140545^1,2		--	13923947(+)	`TGAAAC/TAGATC`	4	--	us2k¹		0	--	--	--	--
rs411501^1,2	C,F,A,H,	--	13923976(+)	`ATATAT/GGTGTA`	4	--	us2k¹		23		NS EA NA WA CSA	1329
rs72833139^1,2	C,	--	13924160(+)	`GGATTC/TAGCAA`	4	--	us2k¹		2		NA	122
rs79319511^1,2	C,F,	--	13924248(+)	`GAAGCA/GTGACC`	4	--	us2k¹		1		WA	118

HapMap Linkage Disequilibrium report for RNF182 (13924677 - 13980533 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RNF182: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNF182

DNA2.0 Custom Variant and Variant Library Synthesis for RNF182

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RNF182 for disorders About GeneDecksing

2 diseases for RNF182: About MalaCards

alzheimer's disease neuronitis

Export disorders for RNF182 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for RNF182 gene integrated from 9 sources:
(articles sorted by number of sources associating them with RNF182)

Utopia: connect your pdf to the dynamic
world of online information

A novel brain-enriched E3 ubiquitin ligase RNF182 is up regulated in the brains of Alzheimer's patients and targets ATP6V0C for degr adation. (PubMed id 18298843)^{1, 2} Liu Q.Y....Liu R. (2008)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. (PubMed id 19690564)¹ van Wijk S.J....Timmers H.T. (2009)
Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)¹ Abdelmohsen K....Gorospe M. (2009)
Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)¹ Barbe L....Andersson-Svahn H. (2008)
The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)² Sjoeblom T.... Velculescu V.E. (2006)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)² Mungall A.J.... Beck S. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 221687	HGNC: 28522	AceView: MGC33993	Ensembl:ENSG00000180537	euGenes: HUgn221687
ECgene: RNF182	H-InvDB: RNF182

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for RNF182	Pharmacogenomics, SNPs, Pathways

Intellectual Property for RNF182 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for RNF182 gene:
Search GeneIP for patents involving RNF182

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for RNF182
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RNF182		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNF182
	OriGene Protein Over-expression Lysate for RNF182		Browse OriGene Fluorogenic Cell Assay Kits
	Browse OriGene siRNAs		OriGene 3'-UTR Clone for RNF182
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF182		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF182
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for RNF182		OriGene Custom Protein Services for RNF182
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RNF182
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNF182
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF182
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNF182
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNF182
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNF182

	GenScript Custom Purified and Recombinant Proteins Services for RNF182		GenScript cDNA clones with any tag delivered in your preferred vector for RNF182
	GenScript Custom Assay Services for RNF182		GenScript Custom Superior Antibodies Services for RNF182
	GenScript Custom overexpressing Cell Line Services for RNF182		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in RNF182 promoter
	Search Chromatin IP Primers for RNF182
	RT² qPCR Primer Assay in human, mouse, rat RNF182
	Search GNC Networks for RNF182
	SABiosciences Custom PCR Arrays for RNF182

Search Tocris compounds for RNF182

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	RNF182 antibodies
	RNF182 proteins
	RNF182 lysates

	Search for Antibodies for RNF182 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for RNF182
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

RNF182 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for RNF182

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF182

	SwitchGear 3'UTR luciferase reporter plasmids for RNF182
	SwitchGear Promoter luciferase reporter plasmids for RNF182

Search ThermoFisher Antibodies for RNF182

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF182

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes RNF182 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

RNF182 Gene

ring finger protein 182

Aliases
for RNF182 gene

Summaries
for RNF182 gene

Genomic Views
for RNF182 gene

Proteins
for RNF182 gene

Protein Domains /
Families
for RNF182 gene

Function
for RNF182 gene

Pathways & Interactions
for RNF182 gene

Drugs & Compounds
for RNF182 gene

Transcripts
for RNF182 gene

Expression
for RNF182 gene

Orthologs
for RNF182 gene

Paralogs
for RNF182 gene

Genomic Variants
for RNF182 gene

Disorders / Diseases
for RNF182 gene

Publications
for RNF182 gene

External Searches for RNF182 gene

Genome Databases showing RNF182 gene

Other Databases showing RNF182 gene

Specialized Databases showing RNF182 gene

Intellectual Property
for RNF182 gene

Products
for RNF182 gene

View Random Gene

Advanced Search

Export list of displayed genes

RNF182 Gene

ring finger protein 182

Aliasesfor RNF182 gene

Summariesfor RNF182 gene

Genomic Viewsfor RNF182 gene

Proteinsfor RNF182 gene

Protein Domains /Familiesfor RNF182 gene

Functionfor RNF182 gene

Pathways & Interactionsfor RNF182 gene

Drugs & Compoundsfor RNF182 gene

Transcriptsfor RNF182 gene

Expression for RNF182 gene

Orthologsfor RNF182 gene

Paralogsfor RNF182 gene

Genomic Variantsfor RNF182 gene

Disorders / Diseasesfor RNF182 gene

Publicationsfor RNF182 gene

External Searches for RNF182 gene

Genome Databases showing RNF182 gene

Other Databases showing RNF182 gene

Specialized Databases showing RNF182 gene

Intellectual Propertyfor RNF182 gene

Productsfor RNF182 gene

View Random Gene

Aliases
for RNF182 gene

Summaries
for RNF182 gene

Genomic Views
for RNF182 gene

Proteins
for RNF182 gene

Protein Domains /
Families
for RNF182 gene

Function
for RNF182 gene

Pathways & Interactions
for RNF182 gene

Drugs & Compounds
for RNF182 gene

Transcripts
for RNF182 gene

Expression
for RNF182 gene

Orthologs
for RNF182 gene

Paralogs
for RNF182 gene

Genomic Variants
for RNF182 gene

Disorders / Diseases
for RNF182 gene

Publications
for RNF182 gene

Intellectual Property
for RNF182 gene

Products
for RNF182 gene