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Aliases for RNF182 Gene

Aliases for RNF182 Gene

  • Ring Finger Protein 182 2 3
  • RING Finger Protein 182 4 5
  • EC 6.3.2.- 4

External Ids for RNF182 Gene

Previous GeneCards Identifiers for RNF182 Gene

  • GC06P014034

Summaries for RNF182 Gene

GeneCards Summary for RNF182 Gene

RNF182 (Ring Finger Protein 182) is a Protein Coding gene. Among its related pathways are Antigen processing- Ubiquitination and Proteasome degradation and Immune System. GO annotations related to this gene include ligase activity and ubiquitin-protein transferase activity.

UniProtKB/Swiss-Prot for RNF182 Gene

  • E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C and targets it to degradation via the ubiquitin-proteasome pathway.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF182 Gene

Genomics for RNF182 Gene

Regulatory Elements for RNF182 Gene

Enhancers for RNF182 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RNF182 on UCSC Golden Path with GeneCards custom track

Promoters for RNF182 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RNF182 on UCSC Golden Path with GeneCards custom track

Genomic Location for RNF182 Gene

Chromosome:
6
Start:
13,924,446 bp from pter
End:
13,980,302 bp from pter
Size:
55,857 bases
Orientation:
Plus strand

Genomic View for RNF182 Gene

Genes around RNF182 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF182 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF182 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF182 Gene

Proteins for RNF182 Gene

  • Protein details for RNF182 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N6D2-RN182_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase RNF182
    Protein Accession:
    Q8N6D2
    Secondary Accessions:
    • B2RDG2
    • Q8NBG3

    Protein attributes for RNF182 Gene

    Size:
    247 amino acids
    Molecular mass:
    27402 Da
    Quaternary structure:
    • Interacts with ATP6V0C.

neXtProt entry for RNF182 Gene

Proteomics data for RNF182 Gene at MOPED

Post-translational modifications for RNF182 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RNF182 Gene

Domains & Families for RNF182 Gene

Gene Families for RNF182 Gene

Protein Domains for RNF182 Gene

Suggested Antigen Peptide Sequences for RNF182 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N6D2

UniProtKB/Swiss-Prot:

RN182_HUMAN :
  • The RING-type zinc finger domain is required for E3 ligase activity.
  • Contains 1 RING-type zinc finger.
Domain:
  • The RING-type zinc finger domain is required for E3 ligase activity.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF182: view

Function for RNF182 Gene

Molecular function for RNF182 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C and targets it to degradation via the ubiquitin-proteasome pathway.

Enzyme Numbers (IUBMB) for RNF182 Gene

Gene Ontology (GO) - Molecular Function for RNF182 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 18298843
GO:0005515 protein binding IEA,IPI 18298843
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with RNF182: view

Phenotypes for RNF182 Gene

genes like me logo Genes that share phenotypes with RNF182: view

Animal Model Products

miRNA for RNF182 Gene

miRTarBase miRNAs that target RNF182

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNF182 Gene

Localization for RNF182 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF182 Gene

Membrane; Multi-pass membrane protein. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNF182 Gene COMPARTMENTS Subcellular localization image for RNF182 gene
Compartment Confidence
nucleus 3
cytosol 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for RNF182 Gene

Pathways & Interactions for RNF182 Gene

genes like me logo Genes that share pathways with RNF182: view

UniProtKB/Swiss-Prot Q8N6D2-RN182_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for RNF182 Gene

None

No data available for SIGNOR curated interactions for RNF182 Gene

Drugs & Compounds for RNF182 Gene

No Compound Related Data Available

Transcripts for RNF182 Gene

Unigene Clusters for RNF182 Gene

Ring finger protein 182:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNF182 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c
SP1:
SP2: - - - -
SP3: -
SP4: -

Relevant External Links for RNF182 Gene

GeneLoc Exon Structure for
RNF182
ECgene alternative splicing isoforms for
RNF182

Expression for RNF182 Gene

mRNA expression in normal human tissues for RNF182 Gene

mRNA differential expression in normal tissues according to GTEx for RNF182 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x5.8), Brain - Cerebellum (x5.5), Brain - Anterior cingulate cortex (BA24) (x4.8), Brain - Frontal Cortex (BA9) (x4.8), Brain - Hippocampus (x4.7), and Brain - Cortex (x4.1).

Protein differential expression in normal tissues from HIPED for RNF182 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RNF182 Gene



SOURCE GeneReport for Unigene cluster for RNF182 Gene Hs.111164

mRNA Expression by UniProt/SwissProt for RNF182 Gene

Q8N6D2-RN182_HUMAN
Tissue specificity: Up-regulated in neuronal cells subjected to cell death-inducing injuries, such as oxygen and glucose deprivation (at protein level). Could be up-regulated in Alzheimer disease brains.
genes like me logo Genes that share expression patterns with RNF182: view

Protein tissue co-expression partners for RNF182 Gene

- Elite partner

Primer Products

Orthologs for RNF182 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNF182 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RNF182 35
  • 83.81 (n)
  • 93.52 (a)
RNF182 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNF182 35
  • 91.5 (n)
  • 97.98 (a)
RNF182 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnf182 35
  • 88.53 (n)
  • 98.38 (a)
Rnf182 16
Rnf182 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RNF182 35
  • 99.6 (n)
  • 100 (a)
RNF182 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnf182 35
  • 87.99 (n)
  • 97.57 (a)
oppossum
(Monodelphis domestica)
Mammalia RNF182 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RNF182 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves RNF182 35
  • 82.1 (n)
  • 90.98 (a)
RNF182 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RNF182 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf182 35
  • 76.72 (n)
  • 82.23 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.17893 35
zebrafish
(Danio rerio)
Actinopterygii rnf182 35
  • 57.84 (n)
  • 56.3 (a)
rnf182 36
  • 53 (a)
OneToOne
Species with no ortholog for RNF182:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF182 Gene

ENSEMBL:
Gene Tree for RNF182 (if available)
TreeFam:
Gene Tree for RNF182 (if available)

Paralogs for RNF182 Gene

(1) SIMAP similar genes for RNF182 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for RNF182 Gene

genes like me logo Genes that share paralogs with RNF182: view

No data available for Paralogs for RNF182 Gene

Variants for RNF182 Gene

Sequence variations from dbSNP and Humsavar for RNF182 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_035959 A colorectal cancer sample
VAR_035960 A colorectal cancer sample
rs1041035 -- 13,975,025(+) GGCTG(A/T)AGTCT intron-variant
rs1192057 -- 13,948,158(+) aatac(A/G)ttagt intron-variant
rs1330116 -- 13,970,032(+) TTAAT(A/G)TATAA intron-variant

Variation tolerance for RNF182 Gene

Residual Variation Intolerance Score: 36.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.79; 16.64% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for RNF182 Gene

Disorders for RNF182 Gene

Relevant External Links for RNF182

Genetic Association Database (GAD)
RNF182
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RNF182

No disorders were found for RNF182 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF182 Gene

Publications for RNF182 Gene

  1. A novel brain-enriched E3 ubiquitin ligase RNF182 is up regulated in the brains of Alzheimer's patients and targets ATP6V0C for degradation. (PMID: 18298843) Liu Q.Y. … Liu R. (Mol. Neurodegener. 2008) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines. (PMID: 25260751) Charlaftis N. … Gallagher E. (EMBO J. 2014) 3
  4. Susceptibility loci associated with specific and shared subtypes of lymphoid malignancies. (PMID: 23349640) Vijai J. … Offit K. (PLoS Genet. 2013) 3
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for RNF182 Gene

Sources for RNF182 Gene

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