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Aliases for RNF181 Gene

Aliases for RNF181 Gene

  • Ring Finger Protein 181 2 3
  • E3 Ubiquitin-Protein Ligase RNF181 3
  • RING Finger Protein 181 4
  • EC 6.3.2.- 4
  • HSPC238 3

External Ids for RNF181 Gene

Summaries for RNF181 Gene

Entrez Gene Summary for RNF181 Gene

  • RNF181 binds the integrin alpha-IIb (ITGA2B; MIM 607759)/beta-3 (ITGB3; MIM 173470) complex and has E3 ubiquitin ligase activity (Brophy et al., 2008 [PubMed 18331836]).[supplied by OMIM, Dec 2008]

GeneCards Summary for RNF181 Gene

RNF181 (Ring Finger Protein 181) is a Protein Coding gene. GO annotations related to this gene include ligase activity. An important paralog of this gene is PJA1.

UniProtKB/Swiss-Prot for RNF181 Gene

  • E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF181 Gene

Genomics for RNF181 Gene

Genomic Location for RNF181 Gene

Start:
85,595,268 bp from pter
End:
85,597,708 bp from pter
Size:
2,441 bases
Orientation:
Plus strand

Genomic View for RNF181 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNF181 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF181 Gene

Regulatory Elements for RNF181 Gene

Proteins for RNF181 Gene

  • Protein details for RNF181 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P0P0-RN181_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase RNF181
    Protein Accession:
    Q9P0P0
    Secondary Accessions:
    • Q53H81

    Protein attributes for RNF181 Gene

    Size:
    153 amino acids
    Molecular mass:
    17909 Da
    Quaternary structure:
    • Directly interacts with ITGA2B and, as a result, with integrin ITGA2B/ITGB3. There is no evidence that integrin ITGA2B/ITGB3 is an endogenous substrate for RNF181-directed ubiquitination.

neXtProt entry for RNF181 Gene

Proteomics data for RNF181 Gene at MOPED

Post-translational modifications for RNF181 Gene

Other Protein References for RNF181 Gene

No data available for DME Specific Peptides for RNF181 Gene

Domains for RNF181 Gene

Gene Families for RNF181 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for RNF181 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

RN181_HUMAN
Family:
  • Belongs to the RNF181 family.:
    • Q9P0P0
Similarity:
  • Contains 1 RING-type zinc finger.:
    • Q9P0P0
genes like me logo Genes that share domains with RNF181: view

Function for RNF181 Gene

Molecular function for RNF181 Gene

UniProtKB/Swiss-Prot Function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Enzyme Numbers (IUBMB) for RNF181 Gene

Gene Ontology (GO) - Molecular Function for RNF181 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 24105792
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with RNF181: view

Phenotypes for RNF181 Gene

GenomeRNAi human phenotypes for RNF181:
genes like me logo Genes that share phenotypes with RNF181: view

miRNA for RNF181 Gene

miRTarBase miRNAs that target RNF181

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for RNF181 Gene

Localization for RNF181 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNF181 Gene COMPARTMENTS Subcellular localization image for RNF181 gene
Compartment Confidence
extracellular 3
cytosol 2
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for RNF181 Gene

Pathways for RNF181 Gene

SuperPathways for RNF181 Gene

No Data Available

UniProtKB/Swiss-Prot Q9P0P0-RN181_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for RNF181 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051865 protein autoubiquitination IDA 24105792
genes like me logo Genes that share ontologies with RNF181: view

No data available for Pathways by source for RNF181 Gene

Transcripts for RNF181 Gene

Unigene Clusters for RNF181 Gene

Ring finger protein 181:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNF181 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1: - -
SP2: - -
SP3: - - -
SP4: - - - -
SP5: - - -
SP6: - - -
SP7:
SP8:

Relevant External Links for RNF181 Gene

GeneLoc Exon Structure for
RNF181
ECgene alternative splicing isoforms for
RNF181

Expression for RNF181 Gene

mRNA expression in normal human tissues for RNF181 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RNF181 Gene

SOURCE GeneReport for Unigene cluster for RNF181 Gene Hs.356187

mRNA Expression by UniProt/SwissProt for RNF181 Gene

Q9P0P0-RN181_HUMAN
Tissue specificity: Widely expressed, with highest levels in liver and heart and lowest levels in brain and skeletal muscle. Expressed in platelets (at protein level).
genes like me logo Genes that share expressions with RNF181: view

Orthologs for RNF181 Gene

This gene was present in the common ancestor of animals.

Orthologs for RNF181 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNF181 36
  • 99.78 (n)
  • 99.35 (a)
RNF181 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RNF181 36
  • 91.72 (n)
  • 93.46 (a)
RNF181 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNF181 36
  • 91.94 (n)
  • 92.81 (a)
RNF181 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnf181 36
  • 86.18 (n)
  • 86.18 (a)
Rnf181 16
Rnf181 37
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RNF181 37
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RNF181 37
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnf181 36
  • 87.06 (n)
  • 88.82 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.33490 36
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf181 36
  • 65.35 (n)
  • 67.76 (a)
Str.2943 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7783 36
zebrafish
(Danio rerio)
Actinopterygii rnf181 36
  • 63.83 (n)
  • 65.36 (a)
rnf181 37
  • 65 (a)
OneToOne
zgc56424 36
fruit fly
(Drosophila melanogaster)
Insecta CG7694 37
  • 37 (a)
OneToOne
Species with no ortholog for RNF181:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF181 Gene

ENSEMBL:
Gene Tree for RNF181 (if available)
TreeFam:
Gene Tree for RNF181 (if available)

Paralogs for RNF181 Gene

Paralogs for RNF181 Gene

Selected SIMAP similar genes for RNF181 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for RNF181 Gene

genes like me logo Genes that share paralogs with RNF181: view

Variants for RNF181 Gene

Sequence variations from dbSNP and Humsavar for RNF181 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs6643 - 85,597,128(+) GCCGC(C/T)ATGAG missense, reference, synonymous-codon
rs1127974 -- 85,596,916(+) ATTCT(A/G)CCCTG synonymous-codon, reference, intron-variant
rs1562322 -- 85,594,833(-) CGCTC(A/G)ATCAT upstream-variant-2KB
rs2232738 -- 85,595,493(+) CCCGG(A/G)AATTC upstream-variant-2KB, utr-variant-5-prime
rs2232739 -- 85,595,559(+) TGGCG(G/T)TAGTC upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for RNF181 Gene

Variant ID Type Subtype PubMed ID
esv992753 CNV Deletion 20482838

Relevant External Links for RNF181 Gene

HapMap Linkage Disequilibrium report
RNF181

Disorders for RNF181 Gene

No disorders were found for RNF181 Gene.

No data available for UniProtKB/Swiss-Prot for RNF181 Gene

Publications for RNF181 Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4
  2. RN181, a novel ubiquitin E3 ligase that interacts with the KVGFFKR motif of platelet integrin alpha(IIb)beta3. (PMID: 18331836) Brophy T.M. … Moran N. (Biochem. Biophys. Res. Commun. 2008) 3 4
  3. [Construction of recombinant eukaryotic expression vector pDsRed1-C3/LOC51255 and subcellular localization of LOC51255 protein in HePG2 cell line]. (PMID: 19426595) Huang X. … Li M. (Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2009) 3
  4. A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. (PMID: 19690564) van Wijk S.J. … Timmers H.T. (Mol. Syst. Biol. 2009) 3
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for RNF181 Gene

  • antibodies-online proteins for RNF181
  • antibodies-online antibodies for RNF181
  • antibodies-online kits for RNF181

Sources for RNF181 Gene

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