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Aliases for RNF181 Gene

Aliases for RNF181 Gene

  • Ring Finger Protein 181 2 3
  • RING Finger Protein 181 4 5
  • EC 6.3.2.- 4
  • HSPC238 3

External Ids for RNF181 Gene

Previous GeneCards Identifiers for RNF181 Gene

  • GC02P085676
  • GC02P085822
  • GC02P085719
  • GC02P085606
  • GC02P085609

Summaries for RNF181 Gene

Entrez Gene Summary for RNF181 Gene

  • RNF181 binds the integrin alpha-IIb (ITGA2B; MIM 607759)/beta-3 (ITGB3; MIM 173470) complex and has E3 ubiquitin ligase activity (Brophy et al., 2008 [PubMed 18331836]).[supplied by OMIM, Dec 2008]

GeneCards Summary for RNF181 Gene

RNF181 (Ring Finger Protein 181) is a Protein Coding gene. GO annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is PJA1.

UniProtKB/Swiss-Prot for RNF181 Gene

  • E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF181 Gene

Genomics for RNF181 Gene

Regulatory Elements for RNF181 Gene

Enhancers for RNF181 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RNF181 on UCSC Golden Path with GeneCards custom track

Promoters for RNF181 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RNF181 on UCSC Golden Path with GeneCards custom track

Genomic Location for RNF181 Gene

85,595,268 bp from pter
85,597,708 bp from pter
2,441 bases
Plus strand

Genomic View for RNF181 Gene

Genes around RNF181 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF181 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF181 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF181 Gene

Proteins for RNF181 Gene

  • Protein details for RNF181 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    E3 ubiquitin-protein ligase RNF181
    Protein Accession:
    Secondary Accessions:
    • Q53H81

    Protein attributes for RNF181 Gene

    153 amino acids
    Molecular mass:
    17909 Da
    Quaternary structure:
    • Directly interacts with ITGA2B and, as a result, with integrin ITGA2B/ITGB3. There is no evidence that integrin ITGA2B/ITGB3 is an endogenous substrate for RNF181-directed ubiquitination.

neXtProt entry for RNF181 Gene

Proteomics data for RNF181 Gene at MOPED

Post-translational modifications for RNF181 Gene

Other Protein References for RNF181 Gene

No data available for DME Specific Peptides for RNF181 Gene

Domains & Families for RNF181 Gene

Gene Families for RNF181 Gene

Protein Domains for RNF181 Gene


Suggested Antigen Peptide Sequences for RNF181 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the RNF181 family.
  • Contains 1 RING-type zinc finger.
  • Belongs to the RNF181 family.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF181: view

Function for RNF181 Gene

Molecular function for RNF181 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Enzyme Numbers (IUBMB) for RNF181 Gene

Gene Ontology (GO) - Molecular Function for RNF181 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 24105792
GO:0005515 protein binding IEA --
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with RNF181: view
genes like me logo Genes that share phenotypes with RNF181: view

Animal Model Products

miRNA for RNF181 Gene

miRTarBase miRNAs that target RNF181

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNF181 Gene

Localization for RNF181 Gene

Subcellular locations from

Jensen Localization Image for RNF181 Gene COMPARTMENTS Subcellular localization image for RNF181 gene
Compartment Confidence
cytosol 3
extracellular 3
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RNF181 Gene

Pathways & Interactions for RNF181 Gene

SuperPathways for RNF181 Gene

No Data Available

UniProtKB/Swiss-Prot Q9P0P0-RN181_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for RNF181 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA --
GO:0051865 protein autoubiquitination IDA 24105792
genes like me logo Genes that share ontologies with RNF181: view

No data available for Pathways by source and SIGNOR curated interactions for RNF181 Gene

Drugs & Compounds for RNF181 Gene

No Compound Related Data Available

Transcripts for RNF181 Gene

Unigene Clusters for RNF181 Gene

Ring finger protein 181:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNF181 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1: - -
SP2: - -
SP3: - - -
SP4: - - - -
SP5: - - -
SP6: - - -

Relevant External Links for RNF181 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNF181 Gene

mRNA expression in normal human tissues for RNF181 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RNF181 Gene

This gene is overexpressed in Heart (33.6) and Bone (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RNF181 Gene

SOURCE GeneReport for Unigene cluster for RNF181 Gene Hs.356187

mRNA Expression by UniProt/SwissProt for RNF181 Gene

Tissue specificity: Widely expressed, with highest levels in liver and heart and lowest levels in brain and skeletal muscle. Expressed in platelets (at protein level).
genes like me logo Genes that share expression patterns with RNF181: view

Protein tissue co-expression partners for RNF181 Gene

Primer Products

No data available for mRNA differential expression in normal tissues for RNF181 Gene

Orthologs for RNF181 Gene

This gene was present in the common ancestor of animals.

Orthologs for RNF181 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RNF181 35
  • 91.72 (n)
  • 93.46 (a)
RNF181 36
  • 93 (a)
(Canis familiaris)
Mammalia RNF181 35
  • 91.94 (n)
  • 92.81 (a)
RNF181 36
  • 93 (a)
(Mus musculus)
Mammalia Rnf181 35
  • 86.18 (n)
  • 86.18 (a)
Rnf181 16
Rnf181 36
  • 79 (a)
(Pan troglodytes)
Mammalia RNF181 35
  • 99.78 (n)
  • 99.35 (a)
RNF181 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Rnf181 35
  • 87.06 (n)
  • 88.82 (a)
(Monodelphis domestica)
Mammalia RNF181 36
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia RNF181 36
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf181 35
  • 65.35 (n)
  • 67.76 (a)
Str.2943 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.33490 35
(Danio rerio)
Actinopterygii rnf181 35
  • 63.83 (n)
  • 65.36 (a)
zgc56424 35
rnf181 36
  • 65 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7783 35
fruit fly
(Drosophila melanogaster)
Insecta CG7694 36
  • 37 (a)
Species with no ortholog for RNF181:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF181 Gene

Gene Tree for RNF181 (if available)
Gene Tree for RNF181 (if available)

Paralogs for RNF181 Gene

Paralogs for RNF181 Gene

(7) SIMAP similar genes for RNF181 Gene using alignment to 6 proteins: Pseudogenes for RNF181 Gene

genes like me logo Genes that share paralogs with RNF181: view

Variants for RNF181 Gene

Sequence variations from dbSNP and Humsavar for RNF181 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs6643 - 85,597,128(+) GCCGC(C/T)ATGAG reference, synonymous-codon, missense
rs1562322 -- 85,594,833(-) CGCTC(A/G)ATCAT upstream-variant-2KB
rs3755010 -- 85,594,403(+) CCAGG(C/G)AGGCA upstream-variant-2KB
rs3755011 -- 85,594,476(+) ACCAA(G/T)ACTGT upstream-variant-2KB
rs1127974 -- 85,596,916(+) ATTCT(A/G)CCCTG intron-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for RNF181 Gene

Variant ID Type Subtype PubMed ID
esv992753 CNV Deletion 20482838

Variation tolerance for RNF181 Gene

Residual Variation Intolerance Score: 74.5% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RNF181 Gene

Disorders for RNF181 Gene

Relevant External Links for RNF181

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RNF181 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF181 Gene

Publications for RNF181 Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Negative Regulation of CARD11 Signaling and Lymphoma Cell Survival by the E3 Ubiquitin Ligase RNF181. (PMID: 26711259) Pedersen S.M. … Pomerantz J.L. (Mol. Cell. Biol. 2015) 3
  4. Protein microarray characterization of the S-nitrosoproteome. (PMID: 24105792) Lee Y.I. … Dawson T.M. (Mol. Cell Proteomics 2014) 3
  5. Autoubiquitination of the 26S proteasome on Rpn13 regulates breakdown of ubiquitin conjugates. (PMID: 24811749) Besche H.C. … Goldberg A.L. (EMBO J. 2014) 3

Products for RNF181 Gene

Sources for RNF181 Gene