Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RNF181 Gene

Aliases for RNF181 Gene

  • Ring Finger Protein 181 2 3
  • RING-Type E3 Ubiquitin Transferase RNF181 3 4
  • RING Finger Protein 181 4 5
  • E3 Ubiquitin-Protein Ligase RNF181 3
  • EC 4
  • HSPC238 3

External Ids for RNF181 Gene

Previous GeneCards Identifiers for RNF181 Gene

  • GC02P085676
  • GC02P085822
  • GC02P085719
  • GC02P085606
  • GC02P085609
  • GC02P085611
  • GC02P085613
  • GC02P085615
  • GC02P085617
  • GC02P085621

Summaries for RNF181 Gene

Entrez Gene Summary for RNF181 Gene

  • RNF181 binds the integrin alpha-IIb (ITGA2B; MIM 607759)/beta-3 (ITGB3; MIM 173470) complex and has E3 ubiquitin ligase activity (Brophy et al., 2008 [PubMed 18331836]).[supplied by OMIM, Dec 2008]

GeneCards Summary for RNF181 Gene

RNF181 (Ring Finger Protein 181) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Protein ubiquitination. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is PJA2.

UniProtKB/Swiss-Prot for RNF181 Gene

  • E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Additional gene information for RNF181 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF181 Gene

Genomics for RNF181 Gene

GeneHancer (GH) Regulatory Elements for RNF181 Gene

Promoters and enhancers for RNF181 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I085594 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 555.6 +0.6 622 3.7 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A ZNF2 YY1 POLR2B ZNF766 RNF181 GC02M085595 USP39 VAMP8 GGCX VAMP5
GH02I085582 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 0.4 -10.4 -10436 3.9 PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 IRF4 YY1 VAMP5 VAMP8 GGCX CAPG SH2D6 MAT2A ELMOD3 RETSAT USP39 RNF181
GH02I085587 Enhancer 1.5 FANTOM5 ENCODE dbSUPER 0.4 -5.4 -5441 5.2 PKNOX1 FOXA2 MLX ARNT ARID4B SLC30A9 ZNF766 FOS SP5 NFYC GGCX VAMP8 C2orf68 USP39 CHMP3 VAMP5 RNF181
GH02I085593 Enhancer 0.7 ENCODE 0.8 -2.1 -2115 0.2 ELF3 CTCF TFAP4 MXI1 FOXA2 SAP130 ARID4B ZNF644 RAD21 ZNF48 USP39 RNF181 VAMP5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RNF181 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RNF181 gene promoter:

Genomic Locations for RNF181 Gene

Genomic Locations for RNF181 Gene
2,441 bases
Plus strand

Genomic View for RNF181 Gene

Genes around RNF181 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF181 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF181 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF181 Gene

Proteins for RNF181 Gene

  • Protein details for RNF181 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    E3 ubiquitin-protein ligase RNF181
    Protein Accession:
    Secondary Accessions:
    • Q53H81

    Protein attributes for RNF181 Gene

    153 amino acids
    Molecular mass:
    17909 Da
    Quaternary structure:
    • Directly interacts with ITGA2B and, as a result, with integrin ITGA2B/ITGB3. There is no evidence that integrin ITGA2B/ITGB3 is an endogenous substrate for RNF181-directed ubiquitination.

neXtProt entry for RNF181 Gene

Post-translational modifications for RNF181 Gene

Other Protein References for RNF181 Gene

No data available for DME Specific Peptides for RNF181 Gene

Domains & Families for RNF181 Gene

Gene Families for RNF181 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for RNF181 Gene

Suggested Antigen Peptide Sequences for RNF181 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the RNF181 family.
  • Belongs to the RNF181 family.
genes like me logo Genes that share domains with RNF181: view

Function for RNF181 Gene

Molecular function for RNF181 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Enzyme Numbers (IUBMB) for RNF181 Gene

Gene Ontology (GO) - Molecular Function for RNF181 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 24105792
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
GO:0061630 ubiquitin protein ligase activity EXP,IBA --
genes like me logo Genes that share ontologies with RNF181: view
genes like me logo Genes that share phenotypes with RNF181: view

Animal Model Products

CRISPR Products

miRNA for RNF181 Gene

miRTarBase miRNAs that target RNF181

Inhibitory RNA Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNF181 Gene

Localization for RNF181 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNF181 gene
Compartment Confidence
extracellular 3
cytosol 3
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RNF181 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS --
genes like me logo Genes that share ontologies with RNF181: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RNF181 Gene

Pathways & Interactions for RNF181 Gene

genes like me logo Genes that share pathways with RNF181: view

UniProtKB/Swiss-Prot Q9P0P0-RN181_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for RNF181 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IBA --
GO:0016567 protein ubiquitination TAS --
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA --
GO:0051865 protein autoubiquitination IDA 24105792
genes like me logo Genes that share ontologies with RNF181: view

No data available for SIGNOR curated interactions for RNF181 Gene

Drugs & Compounds for RNF181 Gene

No Compound Related Data Available

Transcripts for RNF181 Gene

Unigene Clusters for RNF181 Gene

Ring finger protein 181:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF181 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1: - -
SP2: - -
SP3: - - -
SP4: - - - -
SP5: - - -
SP6: - - -

Relevant External Links for RNF181 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNF181 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNF181 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RNF181 Gene

This gene is overexpressed in Heart (33.6) and Bone (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RNF181 Gene

Protein tissue co-expression partners for RNF181 Gene

NURSA nuclear receptor signaling pathways regulating expression of RNF181 Gene:


SOURCE GeneReport for Unigene cluster for RNF181 Gene:


mRNA Expression by UniProt/SwissProt for RNF181 Gene:

Tissue specificity: Widely expressed, with highest levels in liver and heart and lowest levels in brain and skeletal muscle. Expressed in platelets (at protein level).

Evidence on tissue expression from TISSUES for RNF181 Gene

  • Nervous system(4.6)
  • Blood(4.1)
genes like me logo Genes that share expression patterns with RNF181: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNF181 Gene

Orthologs for RNF181 Gene

This gene was present in the common ancestor of animals.

Orthologs for RNF181 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RNF181 33 34
  • 99.78 (n)
(Canis familiaris)
Mammalia RNF181 33 34
  • 91.94 (n)
(Bos Taurus)
Mammalia RNF181 34 33
  • 91.72 (n)
(Rattus norvegicus)
Mammalia Rnf181 33
  • 87.06 (n)
(Mus musculus)
Mammalia Rnf181 33 16 34
  • 86.18 (n)
(Ornithorhynchus anatinus)
Mammalia RNF181 34
  • 71 (a)
(Monodelphis domestica)
Mammalia RNF181 34
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf181 33
  • 65.35 (n)
Str.2943 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.33490 33
(Danio rerio)
Actinopterygii rnf181 33 34
  • 63.83 (n)
zgc56424 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7783 33
fruit fly
(Drosophila melanogaster)
Insecta CG7694 34
  • 37 (a)
Species where no ortholog for RNF181 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF181 Gene

Gene Tree for RNF181 (if available)
Gene Tree for RNF181 (if available)

Paralogs for RNF181 Gene

Paralogs for RNF181 Gene

(7) SIMAP similar genes for RNF181 Gene using alignment to 6 proteins: Pseudogenes for RNF181 Gene

genes like me logo Genes that share paralogs with RNF181: view

Variants for RNF181 Gene

Sequence variations from dbSNP and Humsavar for RNF181 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000640763 -- 85,593,553(+) T/C upstream_transcript_variant
rs1001470386 -- 85,593,881(+) G/A upstream_transcript_variant
rs1001611639 -- 85,594,965(+) C/T upstream_transcript_variant
rs1001642708 -- 85,595,343(+) C/G 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1002619365 -- 85,596,424(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RNF181 Gene

Variant ID Type Subtype PubMed ID
esv992753 CNV deletion 20482838

Variation tolerance for RNF181 Gene

Residual Variation Intolerance Score: 74.5% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RNF181 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF181 Gene

Disorders for RNF181 Gene

Additional Disease Information for RNF181

No disorders were found for RNF181 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF181 Gene

Publications for RNF181 Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 2 3 4 58
  2. RN181, a novel ubiquitin E3 ligase that interacts with the KVGFFKR motif of platelet integrin alpha(IIb)beta3. (PMID: 18331836) Brophy TM … Moran N (Biochemical and biophysical research communications 2008) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. Screening and verification of proteins that interact with HSPC238. (PMID: 26398855) Tan JY … Yuan CL (Oncology reports 2015) 3 58

Products for RNF181 Gene

Sources for RNF181 Gene

Loading form....