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Aliases for RNF180 Gene

Aliases for RNF180 Gene

  • Ring Finger Protein 180 2 3
  • E3 Ubiquitin-Protein Ligase RNF180 3
  • RING Finger Protein 180 4
  • EC 6.3.2.- 4
  • RINES 3

External Ids for RNF180 Gene

Previous GeneCards Identifiers for RNF180 Gene

  • GC05P063498
  • GC05P060416

Summaries for RNF180 Gene

GeneCards Summary for RNF180 Gene

RNF180 (Ring Finger Protein 180) is a Protein Coding gene. GO annotations related to this gene include ubiquitin-protein transferase activity and ubiquitin conjugating enzyme binding.

UniProtKB/Swiss-Prot for RNF180 Gene

  • E3 ubiquitin-protein ligase which promotes polyubiquitination and degradation by the proteasome pathway of ZIC2.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF180 Gene

Genomics for RNF180 Gene

Regulatory Elements for RNF180 Gene

Transcription factor binding sites by QIAGEN in the RNF180 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RNF180 Gene

64,165,306 bp from pter
64,372,877 bp from pter
207,572 bases
Plus strand

Genomic View for RNF180 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNF180 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF180 Gene

Proteins for RNF180 Gene

  • Protein details for RNF180 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    E3 ubiquitin-protein ligase RNF180
    Protein Accession:
    Secondary Accessions:
    • Q0JSU3
    • Q495A8
    • Q8NBD1

    Protein attributes for RNF180 Gene

    592 amino acids
    Molecular mass:
    68254 Da
    Quaternary structure:
    • Interacts with ZIC2.
    • Sequence=CAD89939.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RNF180 Gene


neXtProt entry for RNF180 Gene

Proteomics data for RNF180 Gene at MOPED

Post-translational modifications for RNF180 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RNF180 Gene

Antibody Products

No data available for DME Specific Peptides for RNF180 Gene

Domains for RNF180 Gene

Gene Families for RNF180 Gene

  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for RNF180 Gene

Suggested Antigen Peptide Sequences for RNF180 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q86T96
  • The RING-type zinc finger domain mediates polyubiquitination of the interacting protein
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF180: view

Function for RNF180 Gene

Molecular function for RNF180 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase which promotes polyubiquitination and degradation by the proteasome pathway of ZIC2.

Enzyme Numbers (IUBMB) for RNF180 Gene

Gene Ontology (GO) - Molecular Function for RNF180 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IEA --
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0031624 ubiquitin conjugating enzyme binding IEA --
genes like me logo Genes that share ontologies with RNF180: view

Phenotypes for RNF180 Gene

GenomeRNAi human phenotypes for RNF180:
genes like me logo Genes that share phenotypes with RNF180: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNF180

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RNF180 Gene

Localization for RNF180 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF180 Gene

Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus envelope.

Subcellular locations from

Jensen Localization Image for RNF180 Gene COMPARTMENTS Subcellular localization image for RNF180 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 3
cytosol 1

Gene Ontology (GO) - Cellular Components for RNF180 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005635 nuclear envelope IEA --
GO:0016021 integral component of membrane IEA --
GO:0031227 intrinsic component of endoplasmic reticulum membrane IEA --
genes like me logo Genes that share ontologies with RNF180: view

Pathways for RNF180 Gene

SuperPathways for RNF180 Gene

No Data Available

UniProtKB/Swiss-Prot Q86T96-RN180_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Interacting Proteins for RNF180 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000373752 Q86T96-RN180_HUMAN for RNF180 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for RNF180 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IEA --
GO:0030534 adult behavior IEA --
GO:0031398 positive regulation of protein ubiquitination IEA --
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA --
GO:0042415 norepinephrine metabolic process IEA --
genes like me logo Genes that share ontologies with RNF180: view

No data available for Pathways by source for RNF180 Gene

Transcripts for RNF180 Gene

Unigene Clusters for RNF180 Gene

Ring finger protein 180:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNF180

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF180 Gene

No ASD Table

Relevant External Links for RNF180 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNF180 Gene

mRNA expression in normal human tissues for RNF180 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNF180 Gene

This gene is overexpressed in Artery - Tibial (4.0).

Protein differential expression in normal tissues for RNF180 Gene

This gene is overexpressed in Breast (34.9) and Stomach (34.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RNF180 Gene

SOURCE GeneReport for Unigene cluster for RNF180 Gene Hs.657843

genes like me logo Genes that share expressions with RNF180: view

Expression partners for RNF180 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for RNF180 Gene

Orthologs for RNF180 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNF180 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RNF180 35
  • 90.99 (n)
  • 86.99 (a)
RNF180 36
  • 86 (a)
(Canis familiaris)
Mammalia RNF180 35
  • 91.67 (n)
  • 87.5 (a)
RNF180 36
  • 88 (a)
(Mus musculus)
Mammalia Rnf180 35
  • 83.65 (n)
  • 80.42 (a)
Rnf180 16
Rnf180 36
  • 75 (a)
(Rattus norvegicus)
Mammalia Rnf180 35
  • 85.02 (n)
  • 82.77 (a)
(Monodelphis domestica)
Mammalia RNF180 36
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia RNF180 36
  • 36 (a)
(Pan troglodytes)
Mammalia RNF180 36
  • 99 (a)
(Gallus gallus)
Aves RNF180 35
  • 65.18 (n)
  • 53.93 (a)
RNF180 36
  • 53 (a)
(Anolis carolinensis)
Reptilia RNF180 36
  • 48 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf180 35
  • 58.3 (n)
  • 47.03 (a)
(Danio rerio)
Actinopterygii rnf180 35
  • 54.79 (n)
  • 45.21 (a)
rnf180 36
  • 42 (a)
RNF180 (2 of 2) 36
  • 50 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7166 36
  • 33 (a)
Species with no ortholog for RNF180:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF180 Gene

Gene Tree for RNF180 (if available)
Gene Tree for RNF180 (if available)

Paralogs for RNF180 Gene

No data available for Paralogs for RNF180 Gene

Variants for RNF180 Gene

Sequence variations from dbSNP and Humsavar for RNF180 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs356636 -- 64,166,149(+) GCGGC(C/G)GCGGC intron-variant, upstream-variant-2KB
rs951960 -- 64,177,241(-) GGGAA(A/T)GTGTA intron-variant
rs965491 -- 64,309,952(+) AACTT(G/T)GACTA intron-variant
rs965708 -- 64,252,554(+) CAAGG(C/T)TTTTT intron-variant
rs970990 -- 64,230,097(+) ATTTA(A/G)GTTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNF180 Gene

Variant ID Type Subtype PubMed ID
esv2730269 CNV Deletion 23290073
nsv830322 CNV Gain 17160897
esv2638843 CNV Deletion 19546169
esv2514773 CNV Deletion 19546169

Relevant External Links for RNF180 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF180 Gene

Disorders for RNF180 Gene

Relevant External Links for RNF180

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for RNF180 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for RNF180 Gene

Publications for RNF180 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. Characterization of the gene structure, functional significance, and clinical application of RNF180, a novel gene in gastric cancer. (PMID: 21717426) Cheung K.F. … Yu J. (Cancer 2012) 3
  5. HTR1A a novel type 1 diabetes susceptibility gene on chromosome 5p13-q13. (PMID: 22563461) Asad S. … Kockum I. (PLoS ONE 2012) 3

Products for RNF180 Gene

Sources for RNF180 Gene

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