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RNF180 Gene

protein-coding   GIFtS: 47
GCID: GC05P063498

Ring Finger Protein 180

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ring Finger Protein 1801 2 3
E3 Ubiquitin-Protein Ligase RNF1802
EC 6.3.2.-3

External Ids:    HGNC: 277521   Entrez Gene: 2856712   Ensembl: ENSG000001641977   UniProtKB: Q86T963   

Export aliases for RNF180 gene to outside databases

Previous GC identifer: GC05P060416


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RNF180 Gene:
RNF180 (ring finger protein 180) is a protein-coding gene. Diseases associated with RNF180 include type 1 diabetes. GO annotations related to this gene include ubiquitin-protein ligase activity and ubiquitin conjugating enzyme binding.

UniProtKB/Swiss-Prot: RN180_HUMAN, Q86T96
Function: E3 ubiquitin-protein ligase which promotes polyubiquitination and degradation by the proteasome pathway
of ZIC2 (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NT_034772.7  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RNF180 gene promoter:
         Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNF180 promoter sequence
   Search Chromatin IP Primers for RNF180

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNF180


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q12.3   Ensembl cytogenetic band:  5q12.3   HGNC cytogenetic band: 5q12.3

RNF180 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF180 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P063498:  view genomic region     (about GC identifiers)

Start:
63,461,671 bp from pter      End:
63,668,696 bp from pter
Size:
207,026 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RN180_HUMAN, Q86T96 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase RNF180  
Size: 592 amino acids; 68254 Da
Subunit: Interacts with ZIC2 (By similarity)
Sequence caution: Sequence=CAD89939.1; Type=Erroneous initiation;
Secondary accessions: Q0JSU3 Q495A8 Q8NBD1
Alternative splicing: 3 isoforms:  Q86T96-1   Q86T96-2   Q86T96-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RNF180: NX_Q86T96

Explore proteomics data for RNF180 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RNF180 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001107033.1  NP_848627.1  

    ENSEMBL proteins: 
     ENSP00000296615   ENSP00000373752   ENSP00000426884   ENSP00000370471  

    RNF180 Human Recombinant Protein Products:

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    Cloud-Clone Corp. ELISAs for RNF180
    Cloud-Clone Corp. CLIAs for RNF180


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers

    3 InterPro protein domains:
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q86T96

    ProtoNet protein and cluster: Q86T96

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: RN180_HUMAN, Q86T96
    Domain: The RING-type zinc finger domain mediates polyubiquitination of the interacting protein
    Similarity: Contains 1 RING-type zinc finger


    RNF180 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RN180_HUMAN, Q86T96
    Function: E3 ubiquitin-protein ligase which promotes polyubiquitination and degradation by the proteasome pathway
    of ZIC2 (By similarity)

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IEA--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0031624ubiquitin conjugating enzyme binding IEA--
    GO:0046872metal ion binding ----
         
    RNF180 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RNF180:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RNF180
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    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate RNF180 (see all 55):
    hsa-miR-142-5p hsa-miR-302d hsa-miR-520e hsa-miR-25 hsa-miR-301a hsa-miR-519a hsa-miR-570 hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidRNF180 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RNF180

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF180


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RN180_HUMAN, Q86T96: Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus envelope (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    nucleus3
    cytosol1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005635nuclear envelope IEA--
    GO:0016021integral component of membrane IEA--
    GO:0031227intrinsic component of endoplasmic reticulum membrane IEA--

    RNF180 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    UniProtKB/Swiss-Prot: RN180_HUMAN, Q86T96
    Pathway: Protein modification; protein ubiquitination

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RNF180
    Interactions:

        Search GeneGlobe Interaction Network for RNF180

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for RNF180 (Q86T963 ENSP000003737524) via UniProtKB, MINT, STRING, and/or I2D

    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    ZIC2O954093, ENSP000003655144I2D: score=1 STRING: ENSP00000365514
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA--

    RNF180 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RNF180 (RN180)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RNF180 gene (2 alternative transcripts): 
    NM_001113561.1  NM_178532.3  

    Unigene Cluster for RNF180:

    Ring finger protein 180
    Hs.657843  [show with all ESTs]
    Unigene Representative Sequence: NM_001113561
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000296615(uc003jth.4) ENST00000389100(uc003jti.3) ENST00000504296
    ENST00000381081(uc010iws.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RNF180 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RNF180 (see all 55):
    hsa-miR-142-5p hsa-miR-302d hsa-miR-520e hsa-miR-25 hsa-miR-301a hsa-miR-519a hsa-miR-570 hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidRNF180 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RNF180
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    GenScript: all cDNA clones in your preferred vector (see all 2): RNF180 (NM_001113561)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF180
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for RNF180
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RNF180
      QuantiTect SYBR Green Assays in human, mouse, rat RNF180
      QuantiFast Probe-based Assays in human, mouse, rat RNF180

    Additional mRNA sequence: 

    AK090756.1 AL832580.2 BC101277.2 BC101278.2 BC101279.1 BC101397.2 

    3 DOTS entries:

    DT.308885  DT.100020671  DT.307726 

    Selected AceView cDNA sequences (see all 34):

    BI006702 BM718923 BX113020 BE672684 BM728889 CB999963 AI167804 CB267379 
    BE218282 AI216189 BE222198 AX746601 AI431828 AK090756 AA035198 AI521986 
    AI273646 NM_178532 BF115015 AL832580 BF433928 BV192623 W33182 AA040069 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RNF180 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGAATAAAA
    RNF180 Expression
    About this image


    RNF180 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Eye (Sensory Organs)
             Lens
     
     Spleen (Hematopoietic System)
             Conventional Dendritic Cells I Spleen
    RNF180 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RNF180 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.657843
        Custom PCR Arrays for RNF180
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF180

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for RNF180 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnf1801 , 5 ring finger protein 1801, 5 83.65(n)1
    80.42(a)1
      13 (56.92 cM)5
    718161  NM_027934.21  NP_082210.11 
     1051493525 
    chicken
    (Gallus gallus)
    Aves RNF1801 ring finger protein 180 65.18(n)
    53.93(a)
      101747752  XM_004937273.1  XP_004937330.1 
    lizard
    (Anolis carolinensis)
    Reptilia RNF1806
    ring finger protein 180
    48(a)
    1 ↔ 1
    1(226221712-226277061)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia rnf1801 ring finger protein 180 58.3(n)
    47.03(a)
      100135724  NM_001114254.2  NP_001107726.2 
    zebrafish
    (Danio rerio)
    Actinopterygii rnf1801 ring finger protein 180 54.79(n)
    45.21(a)
      793295  NM_001110404.1  NP_001103874.1 


    ENSEMBL Gene Tree for RNF180 (if available)
    TreeFam Gene Tree for RNF180 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RNF180 (see all 3706)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1861446431,2
    --63459672(+) GTGGAA/GAAAGT 2 -- us2k10--------
    rs781995601,2
    F--63459718(+) CCTACG/ATAGGT 2 -- us2k12Minor allele frequency- A:0.02CSA WA 120
    rs1429828541,2
    --63459916(+) AACCAC/GTTTGT 2 -- us2k10--------
    rs1509202891,2
    C--63460197(+) GGTTAC/TAGAAA 2 -- us2k10--------
    rs764387791,2
    F--63460221(+) AAACTG/AAGAGC 2 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1923533181,2
    --63460380(+) GAAGTA/GGCAAC 2 -- us2k10--------
    rs1823819041,2
    --63460510(+) TATTCC/GTAGTT 2 -- us2k10--------
    rs1133741761,2
    C,F--63460514(+) CCTAGC/TTGAAG 2 -- us2k11Minor allele frequency- T:0.50NA 2
    rs1878695151,2
    --63460517(+) AGTTGA/GAGTGT 2 -- us2k10--------
    rs1446298801,2
    --63460571(+) TCATCA/TTTTGA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for RNF180 (63461671 - 63668696 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for RNF180:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2514773CNV Deletion19546169
    esv2730269CNV Deletion23290073
    esv2638843CNV Deletion19546169
    nsv830322CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for RNF180:    
    About MalaCards
    type 1 diabetes


    RNF180 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RNF180
    Human Genome Epidemiology (HuGE) Navigator: RNF180 (1 document)

    Export disorders for RNF180 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RNF180 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with RNF180)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Protein interaction discovery using parallel analysis of translated ORFs (PLATO). (PubMed id 23503679)1 Zhu J....Elledge S.J. (Nat. Biotechnol. 2013)
    5. HTR1A a novel type 1 diabetes susceptibility gene on chromosome 5p13-q13. (PubMed id 22563461)1 Asad S....Kockum I. (PLoS ONE 2012)
    6. Characterization of the gene structure, functional significance, and clinical application of RNF180, a novel gene in gastric cancer. (PubMed id 21717426)1 Cheung K.F....Yu J. (Cancer 2012)
    7. Rines/RNF180, a novel RING finger gene-encoded product, is a membrane-bound ubiquitin ligase. (PubMed id 18363970)1 Ogawa M....Aruga J. (amp 2008)
    8. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    9. The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (Nucleic Acids Res. 2006)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 285671 HGNC: 27752 AceView: LOC285671 Ensembl:ENSG00000164197 euGenes: HUgn285671
    ECgene: RNF180 H-InvDB: RNF180

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RNF180 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RNF180 gene:
    Search GeneIP for patents involving RNF180

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

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