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Aliases for RNF175 Gene

Aliases for RNF175 Gene

  • Ring Finger Protein 175 2 3 5

External Ids for RNF175 Gene

Previous GeneCards Identifiers for RNF175 Gene

  • GC04M154989
  • GC04M154850
  • GC04M154631
  • GC04M150362

Summaries for RNF175 Gene

GeneCards Summary for RNF175 Gene

RNF175 (Ring Finger Protein 175) is a Protein Coding gene. GO annotations related to this gene include ubiquitin protein ligase activity. An important paralog of this gene is RNF121.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF175 Gene

Genomics for RNF175 Gene

Regulatory Elements for RNF175 Gene

Enhancers for RNF175 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F153683 1 Ensembl ENCODE 15.9 +75.1 75135 3.4 CTCF USF1 MAX DNMT3B YY1 POLR2A HNF4G FOS PAF1 ZNF687 TLR2 RNF175 LOC105377499
GH04F153650 1.7 FANTOM5 Ensembl ENCODE 9.2 +106.4 106424 6.4 ATF1 ARID4B DMAP1 YY1 SP5 MXD4 MIER2 PPARG KAT8 NFIL3 TLR2 RNF175 LOC100419170 WDR45P1 PIR44715
GH04F153643 1 Ensembl ENCODE 15.2 +116.8 116835 0.8 ELF3 CTCF HDAC1 IRF2 PKNOX1 RAD21 GATA3 SMC3 MIXL1 ZNF654 RNF175 TLR2 MND1 PIR44715 WDR45P1
GH04F153660 0.9 Ensembl ENCODE 15.5 +99.2 99168 2.1 GATAD2A PAF1 MAX CEBPB CEBPG EP300 RAD21 SSRP1 ATF3 CEBPA RNF175 LOC100419170 WDR45P1 TLR2
GH04F153517 1.3 Ensembl ENCODE 9.2 +234.8 234758 15.8 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ZFP64 ARID4B YBX1 YY1 GATA2 KIAA0922 MND1 RNF175 PIR33610 PIR44013
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RNF175 on UCSC Golden Path with GeneCards custom track

Promoters for RNF175 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001252466 335 1001 L3MBTL2 POLR2A CBX2 CTBP2 EZH2

Genomic Location for RNF175 Gene

153,707,672 bp from pter
153,760,235 bp from pter
52,564 bases
Minus strand

Genomic View for RNF175 Gene

Genes around RNF175 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF175 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF175 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF175 Gene

Proteins for RNF175 Gene

  • Protein details for RNF175 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RING finger protein 175
    Protein Accession:
    Secondary Accessions:
    • C9JL66
    • Q8NB61

    Protein attributes for RNF175 Gene

    328 amino acids
    Molecular mass:
    38266 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RNF175 Gene


neXtProt entry for RNF175 Gene

Post-translational modifications for RNF175 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RNF175 Gene

Domains & Families for RNF175 Gene

Gene Families for RNF175 Gene

Protein Domains for RNF175 Gene

Suggested Antigen Peptide Sequences for RNF175 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 RING-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF175: view

Function for RNF175 Gene

Gene Ontology (GO) - Molecular Function for RNF175 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
GO:0061630 ubiquitin protein ligase activity IBA --
genes like me logo Genes that share ontologies with RNF175: view

Phenotypes for RNF175 Gene

genes like me logo Genes that share phenotypes with RNF175: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RNF175 Gene

Localization for RNF175 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF175 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNF175 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 3
golgi apparatus 3
peroxisome 2

Gene Ontology (GO) - Cellular Components for RNF175 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IBA --
GO:0005789 endoplasmic reticulum membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RNF175: view

Pathways & Interactions for RNF175 Gene

SuperPathways for RNF175 Gene

No Data Available

Interacting Proteins for RNF175 Gene

Gene Ontology (GO) - Biological Process for RNF175 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process IBA --
GO:0030968 endoplasmic reticulum unfolded protein response IBA --
genes like me logo Genes that share ontologies with RNF175: view

No data available for Pathways by source and SIGNOR curated interactions for RNF175 Gene

Transcripts for RNF175 Gene

Unigene Clusters for RNF175 Gene

Ring finger protein 175:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF175 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10
SP1: - - - -
SP2: - - -
SP3: - - - -
SP5: -
SP6: - - - - -
SP7: -

Relevant External Links for RNF175 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNF175 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RNF175 Gene

mRNA differential expression in normal tissues according to GTEx for RNF175 Gene

This gene is overexpressed in Whole Blood (x5.7), Brain - Frontal Cortex (BA9) (x4.8), Brain - Cortex (x4.4), and Brain - Anterior cingulate cortex (BA24) (x4.2).

Protein differential expression in normal tissues from HIPED for RNF175 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RNF175 Gene

Protein tissue co-expression partners for RNF175 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RNF175 Gene:


SOURCE GeneReport for Unigene cluster for RNF175 Gene:

genes like me logo Genes that share expression patterns with RNF175: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for RNF175 Gene

Orthologs for RNF175 Gene

This gene was present in the common ancestor of animals.

Orthologs for RNF175 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RNF175 34 35
  • 99.7 (n)
(Canis familiaris)
Mammalia RNF175 34 35
  • 90.15 (n)
(Bos Taurus)
Mammalia RNF175 34 35
  • 89.44 (n)
(Danio rerio)
Actinopterygii rnf175 34 35
  • 72.13 (n)
zgc56665 34
fruit fly
(Drosophila melanogaster)
Insecta CG15814 35
  • 55 (a)
(Caenorhabditis elegans)
Secernentea rnf-121 35
  • 37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 60 (a)
Species where no ortholog for RNF175 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RNF175 Gene

Gene Tree for RNF175 (if available)
Gene Tree for RNF175 (if available)

Paralogs for RNF175 Gene

Paralogs for RNF175 Gene

(1) SIMAP similar genes for RNF175 Gene using alignment to 6 proteins: Pseudogenes for RNF175 Gene

genes like me logo Genes that share paralogs with RNF175: view

Variants for RNF175 Gene

Sequence variations from dbSNP and Humsavar for RNF175 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10000608 -- 153,716,933(+) ctttg(C/T)atcaa intron-variant
rs10006303 -- 153,724,071(+) CCTGC(A/G)TGTAC intron-variant
rs10009539 -- 153,725,217(+) GGCCT(C/T)AAAAG intron-variant
rs10009844 -- 153,760,424(+) TGCTT(C/T)CTCCA upstream-variant-2KB, utr-variant-5-prime
rs10017081 -- 153,715,374(+) GGGAC(A/T)AACAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNF175 Gene

Variant ID Type Subtype PubMed ID
nsv595749 CNV gain 21841781
nsv10589 CNV gain 18304495
nsv1022081 CNV gain 25217958
esv3602731 CNV loss 21293372
esv2728558 CNV deletion 23290073
esv2728557 CNV deletion 23290073
esv2728556 CNV deletion 23290073
esv2728555 CNV deletion 23290073

Variation tolerance for RNF175 Gene

Residual Variation Intolerance Score: 91.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.57; 91.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNF175 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF175 Gene

Disorders for RNF175 Gene

Relevant External Links for RNF175

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RNF175 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF175 Gene

Publications for RNF175 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  2. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood H.D. … Lan Q. (Occup Environ Med 2009) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins. (PMID: 25350695) Postmus I. … Caulfield M.J. (Nat Commun 2014) 3 64

Products for RNF175 Gene

Sources for RNF175 Gene

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