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Aliases for RNF175 Gene

Aliases for RNF175 Gene

  • Ring Finger Protein 175 2 3

External Ids for RNF175 Gene

Summaries for RNF175 Gene

GeneCards Summary for RNF175 Gene

RNF175 (Ring Finger Protein 175) is a Protein Coding gene. An important paralog of this gene is RNF121.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF175 Gene

Genomics for RNF175 Gene

Genomic Location for RNF175 Gene

Start:
153,710,125 bp from pter
End:
153,760,235 bp from pter
Size:
50,111 bases
Orientation:
Minus strand

Genomic View for RNF175 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNF175 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF175 Gene

Regulatory Elements for RNF175 Gene

Proteins for RNF175 Gene

  • Protein details for RNF175 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N4F7-RN175_HUMAN
    Recommended name:
    RING finger protein 175
    Protein Accession:
    Q8N4F7
    Secondary Accessions:
    • C9JL66
    • Q8NB61

    Protein attributes for RNF175 Gene

    Size:
    328 amino acids
    Molecular mass:
    38266 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RNF175 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNF175 Gene

Proteomics data for RNF175 Gene at MOPED

Post-translational modifications for RNF175 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RNF175 Gene

No data available for DME Specific Peptides for RNF175 Gene

Domains for RNF175 Gene

Gene Families for RNF175 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for RNF175 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

RN175_HUMAN
Similarity:
  • Contains 1 RING-type zinc finger.:
    • Q8N4F7
genes like me logo Genes that share domains with RNF175: view

Function for RNF175 Gene

Gene Ontology (GO) - Molecular Function for RNF175 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0061630 ubiquitin protein ligase activity IBA --
genes like me logo Genes that share ontologies with RNF175: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RNF175 Gene

Localization for RNF175 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF175 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNF175 Gene COMPARTMENTS Subcellular localization image for RNF175 gene
Compartment Confidence
plasma membrane 3
peroxisome 2

Gene Ontology (GO) - Cellular Components for RNF175 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IBA --
GO:0005789 endoplasmic reticulum membrane IBA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RNF175: view

Pathways for RNF175 Gene

SuperPathways for RNF175 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RNF175 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IBA --
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process IBA --
GO:0030968 endoplasmic reticulum unfolded protein response IBA --
genes like me logo Genes that share ontologies with RNF175: view

No data available for Pathways by source for RNF175 Gene

Transcripts for RNF175 Gene

Unigene Clusters for RNF175 Gene

Ring finger protein 175:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNF175 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10
SP1: - - - -
SP2: - - -
SP3: - - - -
SP4:
SP5: -
SP6: - - - - -
SP7: -

Relevant External Links for RNF175 Gene

GeneLoc Exon Structure for
RNF175
ECgene alternative splicing isoforms for
RNF175

Expression for RNF175 Gene

mRNA expression in normal human tissues for RNF175 Gene

mRNA differential expression in normal tissues according to GTEx for RNF175 Gene

This gene is overexpressed in Whole Blood (5.7), Brain - Frontal Cortex (BA9) (4.8), Brain - Cortex (4.4), and Brain - Anterior cingulate cortex (BA24) (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RNF175 Gene

SOURCE GeneReport for Unigene cluster for RNF175 Gene Hs.388364

genes like me logo Genes that share expressions with RNF175: view

Orthologs for RNF175 Gene

This gene was present in the common ancestor of animals.

Orthologs for RNF175 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNF175 36
  • 99.7 (n)
  • 99.39 (a)
RNF175 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RNF175 36
  • 89.44 (n)
  • 92.86 (a)
RNF175 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNF175 36
  • 90.15 (n)
  • 94.81 (a)
RNF175 37
  • 83 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii rnf175 36
  • 72.13 (n)
  • 79.52 (a)
rnf175 37
  • 75 (a)
OneToOne
zgc56665 36
fruit fly
(Drosophila melanogaster)
Insecta CG15814 37
  • 55 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rnf-121 37
  • 37 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 60 (a)
OneToMany
Species with no ortholog for RNF175:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RNF175 Gene

ENSEMBL:
Gene Tree for RNF175 (if available)
TreeFam:
Gene Tree for RNF175 (if available)

Paralogs for RNF175 Gene

Paralogs for RNF175 Gene

Selected SIMAP similar genes for RNF175 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for RNF175 Gene

genes like me logo Genes that share paralogs with RNF175: view

Variants for RNF175 Gene

Sequence variations from dbSNP and Humsavar for RNF175 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs1337 - 153,710,435(-) TATTT(C/G)GTGGC missense, reference
rs1339 - 153,710,411(-) GTGAT(A/G)GGAAT reference, missense
rs981843 -- 153,730,833(+) GGAGC(C/T)ACAGC intron-variant, upstream-variant-2KB
rs981844 -- 153,730,876(+) CTGTA(A/G)ATCCA intron-variant, upstream-variant-2KB
rs1036614 -- 153,717,953(-) gataa(A/C/T)ggtgg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNF175 Gene

Variant ID Type Subtype PubMed ID
nsv482972 CNV Gain 15286789
esv2728555 CNV Deletion 23290073
esv2728556 CNV Deletion 23290073
esv2728557 CNV Deletion 23290073
esv2728558 CNV Deletion 23290073
nsv10589 CNV Gain 18304495

Relevant External Links for RNF175 Gene

HapMap Linkage Disequilibrium report
RNF175

Disorders for RNF175 Gene

Relevant External Links for RNF175

Genetic Association Database (GAD)
RNF175
Human Genome Epidemiology (HuGE) Navigator
RNF175
genes like me logo Genes that share disorders with RNF175: view

No data available for UniProtKB/Swiss-Prot for RNF175 Gene

Publications for RNF175 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood H.D. … Lan Q. (Occup Environ Med 2009) 3 49
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 49
  5. Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph. (PMID: 21048031) Casabonne D. … de Sanjose S. (Haematologica 2011) 3

Products for RNF175 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Ubiquitin Ligases in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate RNF175
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for RNF175
  • Block miRNA regulation of RNF175 using miScript Target Protectors

Sources for RNF175 Gene

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