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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RNF175 Gene

protein-coding GIFtS: 45
GCID: GC04M154631

ring finger protein 175

Explore 3 diseases affiliated with
RNF175 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ring Finger Protein 175¹ ²
FLJ34190¹

External Ids:	HGNC: 27735¹	Entrez Gene: 285533²	Ensembl: ENSG00000145428⁷	UniProtKB: Q8N4F7³

Export aliases for RNF175 gene to outside databases

Previous GC identifers: GC04M154989 GC04M154850 GC04M150362

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000004.11 NC_018915.1 NT_016354.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RNF175 gene promoter:
AML1a ATF-2 NF-AT C/EBPalpha FAC1 NF-AT2 Sox9 NF-AT1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RNF175 promoter sequence

Search SABiosciences Chromatin IP Primers for RNF175

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF175

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q31.3 Ensembl cytogenetic band: 4q31.3 HGNC cytogenetic band: 4q31.3

RNF175 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF175 gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M154631: view genomic region (about GC identifiers)

Start:	154,631,277 bp from pter	End:	154,681,387 bp from pter
Size:	50,111 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RN175_HUMAN, Q8N4F7 (See protein sequence)

Recommended Name: RING finger protein 175

Size: 328 amino acids; 38266 Da

Subcellular location: Membrane; Multi-pass membrane protein (Potential)

Explore the universe of human proteins at neXtProt for RNF175: NX_Q8N4F7

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8N4F7

RNF175 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_775933.1

ENSEMBL proteins:

ENSP00000340979 ENSP00000421761 ENSP00000424430 ENSP00000427472 ENSP00000424563

ENSP00000274068

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	IEA	--

RNF175 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RNF175 for domains About GeneDecksing

2 InterPro domains/families:

IPR001841 Znf_RING

IPR013083 Znf_RING/FYVE/PHD

Graphical View of Domain Structure for InterPro Entry Q8N4F7

ProtoNet protein and cluster: Q8N4F7

1 Blocks protein family: IPB001841 Zn-finger

UniProtKB/Swiss-Prot: RN175_HUMAN, Q8N4F7

Similarity: Contains 1 RING-type zinc finger

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008270	zinc ion binding	IEA	--

RNF175 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for RNF175

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

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Browse Tocris compounds for RNF175
Search CenterWatch for drugs/clinical trials and news about RNF175 / RN175

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for RNF175 gene:

NM_173662.2

Unigene Cluster for RNF175:

Ring finger protein 175

Hs.388364 [show with all ESTs]

Unigene Representative Sequence: AK091509

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000347063(uc003int.3) ENST00000513656 ENST00000503694 ENST00000508248

ENST00000508967 ENST00000506505 ENST00000507512 ENST00000509321 ENST00000506358

ENST00000274068(uc003inu.1)

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Additional cDNA sequence:

AK091509.1 BC034385.1

6 DOTS entries:

DT.209717 DT.100749914 DT.121276038 DT.100018360 DT.121276043 DT.92057043

24/37 AceView cDNA sequences (see all 37):

BX279796 F10085 BI819244 BI823123 BM013820 AI365130 BG202387 R59473

AI142621 AV720984 BU734824 H09541 BI551533 BM013968 AX747029 BI522497

BC034385 NM_173662 AI023856 F12464 BM669323 BM712498 AK091509 AI917412

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for RNF175 (see all 7) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3a	·	3b	·	3c	^	4	^	5	^	6	^	7a	·	7b	^	8a	·	8b	·	8c	^	9	^	10
SP1:											-						-														-		-
SP2:											-						-		-
SP3:											-		-		-		-
SP4:
SP5:																			-

ECgene alternative splicing isoforms for RNF175

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RNF175 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTTTTCATC

About this image

RNF175 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 4 LifeMap Cells

Name

Category

PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)

Heart, Myocardium, Smooth Muscle

PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See RNF175 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RNF175

SOURCE GeneReport for Unigene cluster: Hs.388364

SABiosciences Expression via Pathway-Focused PCR Array including RNF175:

Ubiquitin Ligases in human mouse rat

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for RNF175 gene from 3/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
zebrafish (Danio rerio)	Actinopterygii	zgc56665²	hypothetical protein MGC56665	75.22(n)		393278 BC050174.1
fruit fly (Drosophila melanogaster)	Insecta	CG15814⁶	--	55(a)	1 → many	X(17742143-17744396)
worm (Caenorhabditis elegans)	Secernentea	rnf-121⁶	RING finger protein 121	37(a)	1 → many	III(4168771-4171135)

Species with no ortholog for RNF175

ENSEMBL Gene Tree for RNF175 (if available)
TreeFam Gene Tree for RNF175 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RNF175 gene

RNF121²

1 SIMAP similar gene for RNF175 using alignment to 6 protein entries: RN175_HUMAN (see all proteins):

RNF121

RNF175 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for RNF175
PGOHUM00000249537

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for RNF175
1 CNV: 0051

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RNF175 for disorders About GeneDecksing

3 diseases for RNF175: About MalaCards

chronic lymphocytic leukemia lymphocytic leukemia leukemia

Human Genome Epidemiology (HuGE) Navigator: RNF175 (5 documents)

Export disorders for RNF175 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for RNF175 gene integrated from 9 sources:
(articles sorted by number of sources associating them with RNF175)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Single nucleotide polymorphisms of matrix metalloprot einase 9 (MMP-9) and tumour protein 73 (TP73) interact with Epstein Barr virus in chronic lymphocytic leukemia: results from the European case-control study E piLymph. (PubMed id 21048031)¹ Casabonne D....de Sanjose S. (2010)
Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)¹ Bailey S.D....Anand S. (2010)
Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)¹ Talmud P.J.... . (2009)
Association between genetic variants in VEGF, ERCC3 a nd occupational benzene haematotoxicity. (PubMed id 19773279)¹ Hosgood H.D....Lan Q. (2009)
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)¹ Lamesch P.... Vidal M. (2007)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)² Hillier L.W....Wilson R.K. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)¹ Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 285533	HGNC: 27735	AceView: LOC285533	Ensembl:ENSG00000145428	euGenes: HUgn285533
ECgene: RNF175	H-InvDB: RNF175

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for RNF175	Pharmacogenomics, SNPs, Pathways

Intellectual Property for RNF175 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for RNF175 gene:
Search GeneIP for patents involving RNF175

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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About This Section


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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes RNF175 gene at Home site.

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RNF175 Gene

ring finger protein 175

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RNF175 Gene

ring finger protein 175

Aliasesfor RNF175 gene

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Genomic Viewsfor RNF175 gene

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Protein Domains /Familiesfor RNF175 gene

Functionfor RNF175 gene

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Drugs & Compoundsfor RNF175 gene

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Expression for RNF175 gene

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Genomic Variantsfor RNF175 gene

Disorders / Diseasesfor RNF175 gene

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External Searches for RNF175 gene

Genome Databases showing RNF175 gene

Other Databases showing RNF175 gene

Specialized Databases showing RNF175 gene

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for RNF175 gene

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for RNF175 gene

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for RNF175 gene

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for RNF175 gene

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for RNF175 gene

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for RNF175 gene

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for RNF175 gene

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for RNF175 gene

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for RNF175 gene

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for RNF175 gene

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