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Aliases for RNF175 Gene

Aliases for RNF175 Gene

  • Ring Finger Protein 175 2 3 5

External Ids for RNF175 Gene

Previous GeneCards Identifiers for RNF175 Gene

  • GC04M154989
  • GC04M154850
  • GC04M154631
  • GC04M150362

Summaries for RNF175 Gene

GeneCards Summary for RNF175 Gene

RNF175 (Ring Finger Protein 175) is a Protein Coding gene. GO annotations related to this gene include ubiquitin protein ligase activity. An important paralog of this gene is RNF121.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF175 Gene

Genomics for RNF175 Gene

Regulatory Elements for RNF175 Gene

Promoters for RNF175 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RNF175 on UCSC Golden Path with GeneCards custom track

Genomic Location for RNF175 Gene

153,707,672 bp from pter
153,760,235 bp from pter
52,564 bases
Minus strand

Genomic View for RNF175 Gene

Genes around RNF175 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF175 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF175 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF175 Gene

Proteins for RNF175 Gene

  • Protein details for RNF175 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RING finger protein 175
    Protein Accession:
    Secondary Accessions:
    • C9JL66
    • Q8NB61

    Protein attributes for RNF175 Gene

    328 amino acids
    Molecular mass:
    38266 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RNF175 Gene


neXtProt entry for RNF175 Gene

Proteomics data for RNF175 Gene at MOPED

Post-translational modifications for RNF175 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RNF175 Gene

No data available for DME Specific Peptides for RNF175 Gene

Domains & Families for RNF175 Gene

Gene Families for RNF175 Gene

Protein Domains for RNF175 Gene


Suggested Antigen Peptide Sequences for RNF175 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 RING-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF175: view

Function for RNF175 Gene

Phenotypes for RNF175 Gene

genes like me logo Genes that share phenotypes with RNF175: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RNF175 Gene

Localization for RNF175 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF175 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for RNF175 Gene COMPARTMENTS Subcellular localization image for RNF175 gene
Compartment Confidence
endoplasmic reticulum 3
golgi apparatus 3
plasma membrane 3
peroxisome 2

No data available for Gene Ontology (GO) - Cellular Components for RNF175 Gene

Pathways & Interactions for RNF175 Gene

SuperPathways for RNF175 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RNF175 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030968 endoplasmic reticulum unfolded protein response IBA --
genes like me logo Genes that share ontologies with RNF175: view

No data available for Pathways by source and SIGNOR curated interactions for RNF175 Gene

Drugs & Compounds for RNF175 Gene

No Compound Related Data Available

Transcripts for RNF175 Gene

Unigene Clusters for RNF175 Gene

Ring finger protein 175:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNF175 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10
SP1: - - - -
SP2: - - -
SP3: - - - -
SP5: -
SP6: - - - - -
SP7: -

Relevant External Links for RNF175 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNF175 Gene

mRNA expression in normal human tissues for RNF175 Gene

mRNA differential expression in normal tissues according to GTEx for RNF175 Gene

This gene is overexpressed in Whole Blood (x5.7), Brain - Frontal Cortex (BA9) (x4.8), Brain - Cortex (x4.4), and Brain - Anterior cingulate cortex (BA24) (x4.2).

Protein differential expression in normal tissues from HIPED for RNF175 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RNF175 Gene

SOURCE GeneReport for Unigene cluster for RNF175 Gene Hs.388364

genes like me logo Genes that share expression patterns with RNF175: view

Protein tissue co-expression partners for RNF175 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for RNF175 Gene

Orthologs for RNF175 Gene

This gene was present in the common ancestor of animals.

Orthologs for RNF175 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RNF175 35
  • 89.44 (n)
  • 92.86 (a)
RNF175 36
  • 92 (a)
(Canis familiaris)
Mammalia RNF175 35
  • 90.15 (n)
  • 94.81 (a)
RNF175 36
  • 83 (a)
(Pan troglodytes)
Mammalia RNF175 35
  • 99.7 (n)
  • 99.39 (a)
RNF175 36
  • 99 (a)
(Danio rerio)
Actinopterygii rnf175 35
  • 72.13 (n)
  • 79.52 (a)
zgc56665 35
rnf175 36
  • 75 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG15814 36
  • 55 (a)
(Caenorhabditis elegans)
Secernentea rnf-121 36
  • 37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 60 (a)
Species with no ortholog for RNF175:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RNF175 Gene

Gene Tree for RNF175 (if available)
Gene Tree for RNF175 (if available)

Paralogs for RNF175 Gene

Paralogs for RNF175 Gene

(1) SIMAP similar genes for RNF175 Gene using alignment to 6 proteins: Pseudogenes for RNF175 Gene

genes like me logo Genes that share paralogs with RNF175: view

Variants for RNF175 Gene

Sequence variations from dbSNP and Humsavar for RNF175 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
VAR_026998 -
rs1337 - 153,710,435(-) TATTT(C/G)GTGGC reference, missense
rs1339 - 153,710,411(-) GTGAT(A/G)GGAAT reference, missense
rs2405432 - 153,710,391(-) CATTA(A/T)CTATT reference, missense
rs1545603 -- 153,761,577(+) gtgac(C/T)gtccg upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RNF175 Gene

Variant ID Type Subtype PubMed ID
nsv482972 CNV Gain 15286789
esv2728555 CNV Deletion 23290073
esv2728556 CNV Deletion 23290073
esv2728557 CNV Deletion 23290073
esv2728558 CNV Deletion 23290073
nsv10589 CNV Gain 18304495

Variation tolerance for RNF175 Gene

Residual Variation Intolerance Score: 91.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.57; 91.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNF175 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF175 Gene

Disorders for RNF175 Gene

Relevant External Links for RNF175

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RNF175 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF175 Gene

Publications for RNF175 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48 67
  2. Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins. (PMID: 25350695) Postmus I. … Caulfield M.J. (Nat Commun 2014) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph. (PMID: 21048031) Casabonne D. … de Sanjose S. (Haematologica 2011) 3
  5. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood H.D. … Lan Q. (Occup Environ Med 2009) 3

Products for RNF175 Gene

Sources for RNF175 Gene

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