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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RNF170 Gene

protein-coding   GIFtS: 50
GCID: GC08M042705

Ring Finger Protein 170

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ring Finger Protein 1701 2 3
Putative LAG1-Interacting Protein2 3
SNAX12
E3 Ubiquitin-Protein Ligase RNF1702
EC 6.3.2.-3

External Ids:    HGNC: 253581   Entrez Gene: 817902   Ensembl: ENSG000001209257   OMIM: 6146495   UniProtKB: Q96K193   

Export aliases for RNF170 gene to outside databases

Previous GC identifers: GC08M042824 GC08M041227


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RNF170 Gene:
This gene encodes a RING domain-containing protein that resides in the endoplasmic reticulum (ER) membrane. This
protein functions as an E3 ubiquitin ligase and mediates ubiquitination and processing of inositol
1,4,5-trisphosphate (IP3) receptors via the ER-associated protein degradation pathway. It is recruited to the
activated IP3 receptors by the ERLIN1/ERLIN2 complex to which it is constitutively bound. Mutations in this gene
are associated with autosomal dominant sensory ataxia. Alternatively spliced transcript variants have been found
for this gene. (provided by RefSeq, Jun 2012)

GeneCards Summary for RNF170 Gene: 
RNF170 (ring finger protein 170) is a protein-coding gene. Diseases associated with RNF170 include ataxia. GO annotations related to this gene include zinc ion binding and ligase activity.

UniProtKB/Swiss-Prot: RN170_HUMAN, Q96K19
Function: E3 ubiquitin-protein ligase that plays an essential role in stimulus-induced inositol
1,4,5-trisphosphate receptor type 1 (ITPR1) ubiquitination and degradation via the endoplasmic
reticulum-associated degradation (ERAD) pathway. Also involved in ITPR1 turnover in resting cells




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.2  NT_167187.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RNF170 gene promoter:
         STAT5B   STAT1   STAT4   STAT1beta   STAT6   STAT5A   STAT1alpha   PPAR-alpha   STAT2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNF170 promoter sequence
   Search SABiosciences Chromatin IP Primers for RNF170

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF170


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p11.21   Ensembl cytogenetic band:  8p11.21   HGNC cytogenetic band: 8p11.21

RNF170 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF170 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M042705:  view genomic region     (about GC identifiers)

Start:
42,704,780 bp from pter      End:
42,752,433 bp from pter
Size:
47,654 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RN170_HUMAN, Q96K19 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase RNF170  
Size: 258 amino acids; 29815 Da
Subunit: Constitutively associated with the ERLIN1/ERLIN 2 complex. Interacts with activated ITPR1
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity)
Sequence caution: Sequence=AAH39461.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=AAH44566.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: D3DSY6 E9PIL4 Q7Z483 Q86YC0 Q8IXR7 Q8N2B5 Q8N5G9 Q8NG30 Q9H0V6
Alternative splicing: 6 isoforms:  Q96K19-1   Q96K19-2   Q96K19-3   Q96K19-4   Q96K19-5   Q96K19-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RNF170: NX_Q96K19

Explore proteomics data for RNF170 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96K19

  • RNF170 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RNF170 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001153695.1  NP_001153696.1  NP_001153697.1  NP_112216.3  

    ENSEMBL proteins: 
     ENSP00000326138   ENSP00000434797   ENSP00000240159   ENSP00000435782   ENSP00000436416  
     ENSP00000437146   ENSP00000445725   ENSP00000325969  

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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral to membrane IEA--

    RNF170 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RNF: RING-type (C3HC4) zinc fingers

    4 InterPro protein domains:
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR010652 DUF1232
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q96K19

    ProtoNet protein and cluster: Q96K19

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: RN170_HUMAN, Q96K19
    Similarity: Contains 1 RING-type zinc finger


    RNF170 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RN170_HUMAN, Q96K19
    Function: E3 ubiquitin-protein ligase that plays an essential role in stimulus-induced inositol
    1,4,5-trisphosphate receptor type 1 (ITPR1) ubiquitination and degradation via the endoplasmic
    reticulum-associated degradation (ERAD) pathway. Also involved in ITPR1 turnover in resting cells

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0016874ligase activity IEA--
    GO:0046872metal ion binding ----
         
    RNF170 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for RNF170:
     Decreased Tat-dependent transc  Decreased p24 protein expressi  Decreased viability of wild-ty 

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    UniProtKB/Swiss-Prot: RN170_HUMAN, Q96K19
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNF170

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5/6 Interacting proteins for RNF170 (Q96K193 ENSP000002401594) via UniProtKB, MINT, STRING, and/or I2D (see all 6)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE2UQ5VVX93, ENSP000003601164I2D: score=2 STRING: ENSP00000360116
    ERLIN2O949053, ENSP000002764614I2D: score=1 STRING: ENSP00000276461
    ITPR1Q146433I2D: score=1 
    SGTAO437653I2D: score=1 
    UBE2AP494593I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016567protein ubiquitination IEA--

    RNF170 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RNF170 (RN170)

    Search CenterWatch for drugs/clinical trials and news about RNF170 / RN170

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RNF170 gene (4 alternative transcripts): 
    NM_001160223.1  NM_001160224.1  NM_001160225.1  NM_030954.3  

    Unigene Cluster for RNF170:

    Ring finger protein 170
    Hs.491626  [show with all ESTs]
    Unigene Representative Sequence: NM_001160223
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000319104(uc011lcx.2) ENST00000527424 ENST00000240159 ENST00000526349
    ENST00000528318(uc003xpq.4) ENST00000531440 ENST00000524954 ENST00000534961(uc010lxp.3 uc003xpo.3 uc003xpm.3 uc003xpp.3)
    ENST00000319073(uc003xpn.3)
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    Additional mRNA sequence: 

    AF209504.1 AK027748.1 AK090864.1 AK225086.1 AK225568.1 AL136620.1 BC032393.1 BC039461.1 
    BC058289.1 NR_027668.1 NR_027669.1 

    12 DOTS entries:

    DT.100785896  DT.211764  DT.424810  DT.101958837  DT.100785891  DT.100785893  DT.91705503  DT.95161168 
    DT.100026051  DT.100785892  DT.91705507  DT.92014543 

    24/124 AceView cDNA sequences (see all 124):

    AI801728 AA648420 AI453450 AK027748 BG109210 NM_030954 N20333 AI088240 
    AA349453 BU684703 CA306336 BC013422 BU608543 AI658891 BC039461 CR608052 
    AA731169 BM832103 AX746655 BF476791 AK090864 BQ771686 AI702320 CR610418 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for RNF170    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9
    SP1:                                                                  
    SP2:              -                                                   
    SP3:              -                       -                           
    SP4:              -                             -     -     -         


    ECgene alternative splicing isoforms for RNF170

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RNF170 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTGAAGTTC
    RNF170 Expression
    About this image


    See RNF170 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RNF170

    SOURCE GeneReport for Unigene cluster: Hs.491626

    UniProtKB/Swiss-Prot: RN170_HUMAN, Q96K19
    Tissue specificity: Expressed in the spinal chord

        SABiosciences Expression via Pathway-Focused PCR Array including RNF170: 
              Ubiquitin Ligases in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RNF170 gene from 8/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnf1701 , 5 ring finger protein 1701, 5 87.03(n)1
    91.05(a)1
      8 (14.38 cM)5
    777331  NM_029965.21  NP_084241.11 
     261193685 
    chicken
    (Gallus gallus)
    Aves RNF1701 ring finger protein 170 78.26(n)
    81.25(a)
      427296  NM_001177737.1  NP_001171208.1 
    lizard
    (Anolis carolinensis)
    Reptilia RNF1706
    --
    --
    75(a)
    41(a)
    1 ↔ 1
    possible ortholog
    GL343339.1(921615-933005)
    4(101503979-101515300)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.154382 Transcribed sequence with weak similarity to protein more 74.5(n)    AL967293.2 
    zebrafish
    (Danio rerio)
    Actinopterygii BC056330.12   -- 72.38(n)    BC056330.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y38F1A.21 Protein Y38F1A.2 45.92(n)
    36.7(a)
      174939  NM_064359.2  NP_496760.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G225101 C3HC4-type RING finger protein 47.7(n)
    38.32(a)
      838857  NM_102100.2  NP_564172.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g08390001 hypothetical protein 48.26(n)
    34.3(a)
      4334720  NM_001058374.1  NP_001051839.1 


    ENSEMBL Gene Tree for RNF170 (if available)
    TreeFam Gene Tree for RNF170 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RNF170 gene
    3 SIMAP similar genes for RNF170 using alignment to 4 protein entries:     RN170_HUMAN (see all proteins):
    TRIM5    TRIM60    TRIM39

    RNF170 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/792 SNPs in RNF170 are shown (see all 792)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0682194
    Ataxia, sensory, 1, autosomal dominant (SNAX1)4--see VAR_0682192 R C mis40--------
    rs342102971,2
    C,F,H--41277067(+) ACTTGC/TGATGG 6 -- us2k19Minor allele frequency- T:0.08NS NA 804
    rs69997721,2
    C,F--41277099(+) tcataA/Tgttga 6 -- us2k11Minor allele frequency- T:0.02WA 118
    rs736353251,2
    C,F--41277112(+) ATACCG/ATAAGT 6 -- us2k13Minor allele frequency- A:0.06WA NA 240
    rs1814055491,2
    --41277131(+) CATTTC/TATACG 6 -- us2k10--------
    rs113813141,2
    C--42706900(+) TTCAGC/-CTCTG 1 -- int12Minor allele frequency- -:0.00NA CSA 4
    rs342720951,2
    C--42722636(+) AAAAA-/AGGCCG 6 -- int11Minor allele frequency- A:0.50NA 2
    rs346685831,2
    C,F--42722641(+) AGGCCG/AGGCGC 6 -- int11Minor allele frequency- A:0.50NA 2
    rs1137260861,2
    C,F--42722700(+) GATCAC/TGAGGT 6 -- int11Minor allele frequency- T:0.50WA 2
    rs357642161,2
    C--42726349(+) TCTCA-/AAAAAA 6 -- int11Minor allele frequency- A:0.50NA 2

    HapMap Linkage Disequilibrium report for RNF170 (42704780 - 42752433 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for RNF170:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv512953CNV Insertion21212237
    esv2628601CNV Insertion19546169
    nsv6171CNV Insertion18451855
    nsv890846CNV Gain21882294


    Human Gene Mutation Database (HGMD): RNF170
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 614649    OMIM disorders: --

    UniProtKB/Swiss-Prot: RN170_HUMAN, Q96K19
  • Ataxia, sensory, 1, autosomal dominant (SNAX1) [MIM:608984]: A rare disease characterized by progressive
    ataxia caused by degeneration of the posterior columns of the spinal cord. Affected individuals have a reduced
    ability to feel pain, temperature and vibration, particularly in the hands and feet. Their most prominent feature
    is an ataxic gait resulting from a severe loss of proprioception. Thus, patients rely on visual cues for
    maintaining proper body posture, such that they are unable to remain upright if their eyes are closed (Romberg
    sign). Note=The disease is caused by mutations affecting the gene represented in this entry

  • 2 diseases for RNF170:    About MalaCards
    ataxia    


    RNF170 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RNF170
    Human Genome Epidemiology (HuGE) Navigator: RNF170 (1 document)

    Export disorders for RNF170 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RNF170 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with RNF170)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (2001)
    2. A mutation in the RNF170 gene causes autosomal domina nt sensory ataxia. (PubMed id 21115467)1, 2 Valdmanis P.N....Rouleau G.A. (2011)
    3. RNF170 protein, an endoplasmic reticulum membrane ubi quitin ligase, mediates inositol 1,4,5-trisphosphate receptor ubiquitination an d degradation. (PubMed id 21610068)1, 2 Lu J.P....Wojcikiewicz R.J. (2011)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Genetic associations of variants in genes encoding HI V-dependency factors required for HIV-1 infection. (PubMed id 21083371)4 Chinn L.W....O'Brien S.J. (2010)
    10. A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. (PubMed id 19690564)1 van Wijk S.J....Timmers H.T. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    OMIM
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 81790 HGNC: 25358 AceView: DKFZP564A022 Ensembl:ENSG00000120925 euGenes: HUgn81790
    ECgene: RNF170 H-InvDB: RNF170

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RNF170 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RNF170 gene:
    Search GeneIP for patents involving RNF170

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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