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Aliases for RNF17 Gene

Aliases for RNF17 Gene

  • Ring Finger Protein 17 2 3
  • Tudor Domain-Containing Protein 4 3 4
  • Spermatogenesis Associated 23 2 3
  • Tudor Domain Containing 4 2 3
  • TDRD4 3 4
  • SPATA23 3
  • Mmip-2 3

External Ids for RNF17 Gene

Previous HGNC Symbols for RNF17 Gene

  • TDRD4

Previous GeneCards Identifiers for RNF17 Gene

  • GC13P023318
  • GC13P019318
  • GC13P024268
  • GC13P023136
  • GC13P024236
  • GC13P025338
  • GC13P006151

Summaries for RNF17 Gene

Entrez Gene Summary for RNF17 Gene

  • This gene is similar to a mouse gene that encodes a testis-specific protein containing a RING finger domain. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, May 2010]

GeneCards Summary for RNF17 Gene

RNF17 (Ring Finger Protein 17) is a Protein Coding gene. GO annotations related to this gene include protein homodimerization activity and hydrolase activity, acting on ester bonds. An important paralog of this gene is TDRD6.

UniProtKB/Swiss-Prot for RNF17 Gene

  • Seems to be involved in regulation of transcriptional activity of MYC. In vitro, inhibits DNA-binding activity of Mad-MAX heterodimers. Can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. May be involved in spermiogenesis (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF17 Gene

Genomics for RNF17 Gene

Regulatory Elements for RNF17 Gene

Genomic Location for RNF17 Gene

Start:
24,764,152 bp from pter
End:
24,888,284 bp from pter
Size:
124,133 bases
Orientation:
Plus strand

Genomic View for RNF17 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNF17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF17 Gene

Proteins for RNF17 Gene

  • Protein details for RNF17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXT8-RNF17_HUMAN
    Recommended name:
    RING finger protein 17
    Protein Accession:
    Q9BXT8
    Secondary Accessions:
    • Q5T2J9
    • Q6P1W3
    • Q9BXT7
    • Q9NUY9

    Protein attributes for RNF17 Gene

    Size:
    1623 amino acids
    Molecular mass:
    184643 Da
    Quaternary structure:
    • Interacts with MXD1, MXD3, MXD4, MXI1 and PIWIL1. Self-associates (By similarity).
    SequenceCaution:
    • Sequence=AAH64847.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91972.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RNF17 Gene

    Alternative splice isoforms for RNF17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNF17 Gene

Proteomics data for RNF17 Gene at MOPED

Post-translational modifications for RNF17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RNF17 Gene

No data available for DME Specific Peptides for RNF17 Gene

Domains for RNF17 Gene

Gene Families for RNF17 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers
  • TDRD :Tudor domain containing

Protein Domains for RNF17 Gene

Suggested Antigen Peptide Sequences for RNF17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BXT8

UniProtKB/Swiss-Prot:

RNF17_HUMAN :
  • Q9BXT8
Domain:
  • Contains 4 Tudor domains.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF17: view

Function for RNF17 Gene

Molecular function for RNF17 Gene

UniProtKB/Swiss-Prot Function: Seems to be involved in regulation of transcriptional activity of MYC. In vitro, inhibits DNA-binding activity of Mad-MAX heterodimers. Can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. May be involved in spermiogenesis (By similarity).

Gene Ontology (GO) - Molecular Function for RNF17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0016788 hydrolase activity, acting on ester bonds --
GO:0042803 protein homodimerization activity IEA --
genes like me logo Genes that share ontologies with RNF17: view
genes like me logo Genes that share phenotypes with RNF17: view

Animal Models for RNF17 Gene

MGI Knock Outs for RNF17:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for RNF17 Gene

Localization for RNF17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF17 Gene

Cytoplasm. Nucleus. Note=Predominantly found in the cytoplasm. Component of a nuage in male germ cells (an electron-dense spherical cytoplasmic body present in late pachytene and diplotene spermatocytes and in elonging spermatids) (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNF17 Gene COMPARTMENTS Subcellular localization image for RNF17 gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for RNF17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with RNF17: view

Pathways for RNF17 Gene

SuperPathways for RNF17 Gene

No Data Available

Interacting Proteins for RNF17 Gene

Gene Ontology (GO) - Biological Process for RNF17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development IEA --
GO:0007286 spermatid development IEA --
GO:0008152 metabolic process --
genes like me logo Genes that share ontologies with RNF17: view

No data available for Pathways by source for RNF17 Gene

Transcripts for RNF17 Gene

Unigene Clusters for RNF17 Gene

Ring finger protein 17:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNF17

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for RNF17

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF17 Gene

No ASD Table

Relevant External Links for RNF17 Gene

GeneLoc Exon Structure for
RNF17
ECgene alternative splicing isoforms for
RNF17

Expression for RNF17 Gene

mRNA expression in normal human tissues for RNF17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNF17 Gene

This gene is overexpressed in Testis (44.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RNF17 Gene

SOURCE GeneReport for Unigene cluster for RNF17 Gene Hs.97464

mRNA Expression by UniProt/SwissProt for RNF17 Gene

Q9BXT8-RNF17_HUMAN
Tissue specificity: Testis specific
genes like me logo Genes that share expressions with RNF17: view

In Situ Assay Products

Orthologs for RNF17 Gene

This gene was present in the common ancestor of animals.

Orthologs for RNF17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNF17 35
  • 99.42 (n)
  • 99.2 (a)
RNF17 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RNF17 35
  • 85.9 (n)
  • 78.85 (a)
RNF17 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNF17 35
  • 88.46 (n)
  • 82.78 (a)
RNF17 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnf17 35
  • 82.47 (n)
  • 75.89 (a)
Rnf17 16
Rnf17 36
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RNF17 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 34 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Rnf17 35
  • 81.31 (n)
  • 75.82 (a)
chicken
(Gallus gallus)
Aves RNF17 35
  • 61.97 (n)
  • 50.17 (a)
RNF17 36
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RNF17 36
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf17 35
  • 55.4 (n)
  • 43.94 (a)
zebrafish
(Danio rerio)
Actinopterygii rnf17 35
  • 47.13 (n)
  • 35.21 (a)
rnf17 36
  • 32 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta qin 36
  • 13 (a)
ManyToMany
tud 36
  • 9 (a)
ManyToMany
Species with no ortholog for RNF17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF17 Gene

ENSEMBL:
Gene Tree for RNF17 (if available)
TreeFam:
Gene Tree for RNF17 (if available)

Paralogs for RNF17 Gene

Paralogs for RNF17 Gene

genes like me logo Genes that share paralogs with RNF17: view

Variants for RNF17 Gene

Sequence variations from dbSNP and Humsavar for RNF17 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs1011337 -- 24,823,448(-) acatg(A/G)caagg intron-variant
rs1026014 -- 24,802,282(-) ACTGC(A/G)AACAA intron-variant
rs1034192 -- 24,867,870(-) ATAAT(A/G)CATGA intron-variant
rs1034193 -- 24,867,319(-) gctgg(A/G)tgtgg intron-variant
rs1052272 -- 24,879,841(+) TCAGC(A/C)CTAGT utr-variant-3-prime, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNF17 Gene

Variant ID Type Subtype PubMed ID
nsv899941 CNV Gain 21882294
esv33422 CNV Loss 17666407
esv2664108 CNV Deletion 23128226

Relevant External Links for RNF17 Gene

HapMap Linkage Disequilibrium report
RNF17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF17 Gene

Disorders for RNF17 Gene

Relevant External Links for RNF17

Genetic Association Database (GAD)
RNF17
genes like me logo Genes that share disorders with RNF17: view

No data available for UniProtKB/Swiss-Prot for RNF17 Gene

Publications for RNF17 Gene

  1. An abundance of X-linked genes expressed in spermatogonia. (PMID: 11279525) Wang P.J. … Page D.C. (Nat. Genet. 2001) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. (PMID: 19690564) van Wijk S.J. … Timmers H.T. (Mol. Syst. Biol. 2009) 3
  4. Tudor domain-containing protein 4 as a potential cancer/testis antigen in liver cancer. (PMID: 21515969) Yoon H. … Kim H. (Tohoku J. Exp. Med. 2011) 3
  5. Expression Analysis of Two Cancer-testis Genes, FBXO39 and TDRD4, in Breast Cancer Tissues and Cell Lines. (PMID: 24377578) Seifi-Alan M. … Najafi-Ashtiani M. (Asian Pac. J. Cancer Prev. 2013) 3

Products for RNF17 Gene

Sources for RNF17 Gene

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