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Aliases for RNF17 Gene

Aliases for RNF17 Gene

  • Ring Finger Protein 17 2 3 5
  • Tudor Domain-Containing Protein 4 3 4
  • Spermatogenesis Associated 23 2 3
  • Tudor Domain Containing 4 2 3
  • TDRD4 3 4
  • SPATA23 3
  • Mmip-2 3

External Ids for RNF17 Gene

Previous HGNC Symbols for RNF17 Gene

  • TDRD4

Previous GeneCards Identifiers for RNF17 Gene

  • GC13P023318
  • GC13P019318
  • GC13P024268
  • GC13P023136
  • GC13P024236
  • GC13P025338
  • GC13P006151
  • GC13P024764

Summaries for RNF17 Gene

Entrez Gene Summary for RNF17 Gene

  • This gene is similar to a mouse gene that encodes a testis-specific protein containing a RING finger domain. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, May 2010]

GeneCards Summary for RNF17 Gene

RNF17 (Ring Finger Protein 17) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and hydrolase activity, acting on ester bonds. An important paralog of this gene is TDRD6.

UniProtKB/Swiss-Prot for RNF17 Gene

  • Seems to be involved in regulation of transcriptional activity of MYC. In vitro, inhibits DNA-binding activity of Mad-MAX heterodimers. Can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. May be involved in spermiogenesis (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF17 Gene

Genomics for RNF17 Gene

Regulatory Elements for RNF17 Gene

Enhancers for RNF17 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RNF17 on UCSC Golden Path with GeneCards custom track

Genomic Location for RNF17 Gene

Chromosome:
13
Start:
24,747,672 bp from pter
End:
24,889,262 bp from pter
Size:
141,591 bases
Orientation:
Plus strand

Genomic View for RNF17 Gene

Genes around RNF17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF17 Gene

Proteins for RNF17 Gene

  • Protein details for RNF17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXT8-RNF17_HUMAN
    Recommended name:
    RING finger protein 17
    Protein Accession:
    Q9BXT8
    Secondary Accessions:
    • Q5T2J9
    • Q6P1W3
    • Q9BXT7
    • Q9NUY9

    Protein attributes for RNF17 Gene

    Size:
    1623 amino acids
    Molecular mass:
    184643 Da
    Quaternary structure:
    • Interacts with MXD1, MXD3, MXD4, MXI1 and PIWIL1. Self-associates (By similarity).
    SequenceCaution:
    • Sequence=AAH64847.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91972.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RNF17 Gene

    Alternative splice isoforms for RNF17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNF17 Gene

Proteomics data for RNF17 Gene at MOPED

Post-translational modifications for RNF17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RNF17 Gene

No data available for DME Specific Peptides for RNF17 Gene

Domains & Families for RNF17 Gene

Gene Families for RNF17 Gene

Protein Domains for RNF17 Gene

Suggested Antigen Peptide Sequences for RNF17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BXT8

UniProtKB/Swiss-Prot:

RNF17_HUMAN :
  • Contains 4 Tudor domains.
  • Contains 1 RING-type zinc finger.
Domain:
  • Contains 4 Tudor domains.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF17: view

Function for RNF17 Gene

Molecular function for RNF17 Gene

UniProtKB/Swiss-Prot Function:
Seems to be involved in regulation of transcriptional activity of MYC. In vitro, inhibits DNA-binding activity of Mad-MAX heterodimers. Can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. May be involved in spermiogenesis (By similarity).

Gene Ontology (GO) - Molecular Function for RNF17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042803 protein homodimerization activity IEA --
genes like me logo Genes that share ontologies with RNF17: view
genes like me logo Genes that share phenotypes with RNF17: view

Animal Models for RNF17 Gene

MGI Knock Outs for RNF17:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for RNF17 Gene

Localization for RNF17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF17 Gene

Cytoplasm. Nucleus. Note=Predominantly found in the cytoplasm. Component of a nuage in male germ cells (an electron-dense spherical cytoplasmic body present in late pachytene and diplotene spermatocytes and in elonging spermatids) (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNF17 Gene COMPARTMENTS Subcellular localization image for RNF17 gene
Compartment Confidence
nucleus 4
cytosol 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for RNF17 Gene

Pathways & Interactions for RNF17 Gene

SuperPathways for RNF17 Gene

No Data Available

Interacting Proteins for RNF17 Gene

Gene Ontology (GO) - Biological Process for RNF17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007286 spermatid development IEA --
genes like me logo Genes that share ontologies with RNF17: view

No data available for Pathways by source and SIGNOR curated interactions for RNF17 Gene

Drugs & Compounds for RNF17 Gene

No Compound Related Data Available

Transcripts for RNF17 Gene

Unigene Clusters for RNF17 Gene

Ring finger protein 17:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNF17 Gene

No ASD Table

Relevant External Links for RNF17 Gene

GeneLoc Exon Structure for
RNF17
ECgene alternative splicing isoforms for
RNF17

Expression for RNF17 Gene

mRNA expression in normal human tissues for RNF17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNF17 Gene

This gene is overexpressed in Testis (x44.4).

Protein differential expression in normal tissues from HIPED for RNF17 Gene

This gene is overexpressed in Testis (28.7), Plasma (12.3), Heart (11.8), and Bone marrow mesenchymal stem cell (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RNF17 Gene



SOURCE GeneReport for Unigene cluster for RNF17 Gene Hs.97464

mRNA Expression by UniProt/SwissProt for RNF17 Gene

Q9BXT8-RNF17_HUMAN
Tissue specificity: Testis specific.
genes like me logo Genes that share expression patterns with RNF17: view

Protein tissue co-expression partners for RNF17 Gene

- Elite partner

Primer Products

Orthologs for RNF17 Gene

This gene was present in the common ancestor of animals.

Orthologs for RNF17 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RNF17 35
  • 85.9 (n)
  • 78.85 (a)
RNF17 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNF17 35
  • 88.46 (n)
  • 82.78 (a)
RNF17 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnf17 35
  • 82.47 (n)
  • 75.89 (a)
Rnf17 16
Rnf17 36
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RNF17 35
  • 99.42 (n)
  • 99.2 (a)
RNF17 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnf17 35
  • 81.31 (n)
  • 75.82 (a)
oppossum
(Monodelphis domestica)
Mammalia RNF17 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 34 (a)
ManyToMany
chicken
(Gallus gallus)
Aves RNF17 35
  • 61.97 (n)
  • 50.17 (a)
RNF17 36
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RNF17 36
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf17 35
  • 55.4 (n)
  • 43.94 (a)
zebrafish
(Danio rerio)
Actinopterygii rnf17 35
  • 47.13 (n)
  • 35.21 (a)
rnf17 36
  • 32 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta qin 36
  • 13 (a)
ManyToMany
tud 36
  • 9 (a)
ManyToMany
Species with no ortholog for RNF17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF17 Gene

ENSEMBL:
Gene Tree for RNF17 (if available)
TreeFam:
Gene Tree for RNF17 (if available)

Paralogs for RNF17 Gene

Paralogs for RNF17 Gene

genes like me logo Genes that share paralogs with RNF17: view

Variants for RNF17 Gene

Sequence variations from dbSNP and Humsavar for RNF17 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1451568 - 24,793,144(+) AAGAA(A/C)AAGGT upstream-variant-2KB, reference, missense
rs9581180 - 24,796,295(+) AACTA(A/G)GTAAT reference, missense
rs9507413 - 24,799,496(+) CTTGT(A/G/T)GTCCA reference, missense
rs10161760 - 24,800,493(+) CATTA(C/G)CACAA reference, missense
rs9511451 - 24,804,338(+) TTTAC(A/G/T)CTATC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for RNF17 Gene

Variant ID Type Subtype PubMed ID
nsv899941 CNV Gain 21882294
esv33422 CNV Loss 17666407
esv2664108 CNV Deletion 23128226

Variation tolerance for RNF17 Gene

Residual Variation Intolerance Score: 49.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.75; 89.41% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RNF17 Gene

Disorders for RNF17 Gene

Relevant External Links for RNF17

Genetic Association Database (GAD)
RNF17
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RNF17

No disorders were found for RNF17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF17 Gene

Publications for RNF17 Gene

  1. An abundance of X-linked genes expressed in spermatogonia. (PMID: 11279525) Wang P.J. … Page D.C. (Nat. Genet. 2001) 2 3 4 67
  2. Expression Analysis of Two Cancer-testis Genes, FBXO39 and TDRD4, in Breast Cancer Tissues and Cell Lines. (PMID: 24377578) Seifi-Alan M. … Najafi-Ashtiani M. (Asian Pac. J. Cancer Prev. 2013) 3
  3. Tudor domain-containing protein 4 as a potential cancer/testis antigen in liver cancer. (PMID: 21515969) Yoon H. … Kim H. (Tohoku J. Exp. Med. 2011) 3
  4. A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. (PMID: 19690564) van Wijk S.J. … Timmers H.T. (Mol. Syst. Biol. 2009) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for RNF17 Gene

Sources for RNF17 Gene

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