Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



RNF167 Gene

protein-coding   GIFtS: 50
GCID: GC17P004845

Ring Finger Protein 167

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Ring Finger Protein 1671 2 3
RING1052 3 5
5730408C10Rik2
E3 Ubiquitin-Protein Ligase RNF1672
EC 6.3.2.-3

External Ids:    HGNC: 245441   Entrez Gene: 260012   Ensembl: ENSG000001085237   OMIM: 6104315   UniProtKB: Q9H6Y73   

Export aliases for RNF167 gene to outside databases

Previous GC identifer: GC17P004784


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for RNF167 Gene:
RNF167 is an E3 ubiquitin ligase that interacts with TSSC5 (SLC22A18; MIM 602631) and, together with UBCH6
(UBE2E1; MIM 602916), facilitates TSSC5 polyubiquitylation (Yamada and Gorbsky, 2006 (PubMed 16314844)).(supplied
by OMIM, Mar 2008)

GeneCards Summary for RNF167 Gene:
RNF167 (ring finger protein 167) is a protein-coding gene. GO annotations related to this gene include ubiquitin-protein ligase activity. An important paralog of this gene is ZNRF3.

UniProtKB/Swiss-Prot: RN167_HUMAN, Q9H6Y7
Function: May act as an E3 ubiquitin-protein ligase, or as part of the E3 complex, which accepts ubiquitin from
specific E2 ubiquitin-conjugating enzymes, such as UBE2E1, and then transfers it to substrates, such as SLC22A18.
May play a role in growth regulation involved in G1/S transition




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010718.17  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RNF167 gene promoter:
         E2F-3a   E2F-5   E2F-1   E2F   AP-1   E2F-2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNF167 promoter sequence
   Search Chromatin IP Primers for RNF167

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNF167


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.2   Ensembl cytogenetic band:  17p13.2   HGNC cytogenetic band: 17p13.3

RNF167 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF167 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P004845:  view genomic region     (about GC identifiers)

Start:
4,843,303 bp from pter      End:
4,848,517 bp from pter
Size:
5,215 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: RN167_HUMAN, Q9H6Y7 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase RNF167 precursor  
Size: 350 amino acids; 38299 Da
Subunit: Interacts with SLC22A18
Sequence caution: Sequence=AAP34453.1; Type=Frameshift; Positions=65;
Secondary accessions: D3DTK8 Q6XYE0 Q8NDC1 Q9Y3V1

Explore the universe of human proteins at neXtProt for RNF167: NX_Q9H6Y7

Explore proteomics data for RNF167 at MOPED

Post-translational modifications: 

  • Auto-ubiquitinated in vitro in the presence of UBE2D1 and UBE2E11
  • Ubiquitination2 at Lys97, Lys210, Lys214, Lys223, Lys272
  • Glycosylation2 at Asn79
  • Modification sites at PhosphoSitePlus

  • See RNF167 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056343.1  
    ENSEMBL proteins: 
     ENSP00000459324   ENSP00000459581   ENSP00000458375   ENSP00000458794   ENSP00000262482  
     ENSP00000458905   ENSP00000460190   ENSP00000458189   ENSP00000460991   ENSP00000460024  
     ENSP00000466753  

    RNF167 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for RNF167
    OriGene Custom MassSpec
    OriGene Custom Protein Services for RNF167
    GenScript Custom Purified and Recombinant Proteins Services for RNF167
    Novus Biologicals RNF167 Proteins
    Novus Biologicals RNF167 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RNF167

     
    Search eBioscience for Proteins for RNF167 

     
    antibodies-online proteins for RNF167 (4 products) 

     
    antibodies-online peptides for RNF167

    RNF167 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for RNF167
    Novus Biologicals RNF167 Antibodies
    Abcam antibodies for RNF167
    Cloud-Clone Corp. Antibodies for RNF167
    Search ThermoFisher Antibodies for RNF167
    antibodies-online antibodies for RNF167 (17 products) 

    RNF167 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RNF167
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RNF167
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RNF167
    Cloud-Clone Corp. CLIAs for RNF167
    Search eBioscience for ELISAs for RNF167 
    antibodies-online kits for RNF167 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers

    3 InterPro protein domains:
     IPR001841 Znf_RING
     IPR003137 Protease-assoc_domain
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q9H6Y7

    ProtoNet protein and cluster: Q9H6Y7

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: RN167_HUMAN, Q9H6Y7
    Similarity: Contains 1 PA (protease associated) domain
    Similarity: Contains 1 RING-type zinc finger


    Find genes that share domains with RNF167           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RN167_HUMAN, Q9H6Y7
    Function: May act as an E3 ubiquitin-protein ligase, or as part of the E3 complex, which accepts ubiquitin from
    specific E2 ubiquitin-conjugating enzymes, such as UBE2E1, and then transfers it to substrates, such as SLC22A18.
    May play a role in growth regulation involved in G1/S transition

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IDA16314844
    GO:0005515protein binding IPI16314844
    GO:0008270zinc ion binding IEA--
    GO:0046872metal ion binding ----
         
    Find genes that share ontologies with RNF167           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for RNF167

    miRNA
    Products:
        
    miRTarBase miRNAs that target RNF167:
    hsa-mir-34a-5p (MIRT047365), hsa-mir-484 (MIRT041982), hsa-mir-186-5p (MIRT045239), hsa-mir-877-5p (MIRT037242)

    Block miRNA regulation of human, mouse, rat RNF167 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate RNF167:
    hsa-miR-19b hsa-miR-590-3p hsa-miR-19a
    SwitchGear 3'UTR luciferase reporter plasmidRNF167 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RNF167
    Predesigned siRNA for gene silencing in human, mouse, rat RNF167

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RNF167

    Clone
    Products:
         
    OriGene clones in human, mouse for RNF167 (see all 8)
    OriGene ORF clones in mouse, rat for RNF167
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RNF167 (NM_015528)
    Sino Biological Human cDNA Clone for RNF167
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNF167
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF167

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RNF167
    Browse ESI BIO Cell Lines and PureStem Progenitors for RNF167 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF167


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    RN167_HUMAN, Q9H6Y7: Endomembrane system; Single-pass membrane protein. Note=Targeted to cytoplasmic membranes
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane2
    endoplasmic reticulum1
    endosome1
    extracellular1
    lysosome1
    peroxisome1
    vacuole1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA16314844
    GO:0012505endomembrane system IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with RNF167           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




    UniProtKB/Swiss-Prot: RN167_HUMAN, Q9H6Y7
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Arrays including RNF167: 

              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for RNF167

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for RNF167 (Q9H6Y73 ENSP000002624824) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE2D2P628373, ENSP000003817174I2D: score=2 STRING: ENSP00000381717
    UBE2D3P610773, ENSP000003497224I2D: score=2 STRING: ENSP00000349722
    UBE2NP610883, ENSP000003161764I2D: score=2 STRING: ENSP00000316176
    UBE2WQ96B023, ENSP000003974534I2D: score=2 STRING: ENSP00000397453
    UBE2MP610813, ENSP000002530234I2D: score=1 STRING: ENSP00000253023
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000209protein polyubiquitination IDA16314844
    GO:0045786negative regulation of cell cycle IMP16314844

    Find genes that share ontologies with RNF167           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RNF167 (RN167)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for RNF167 gene: 
    NM_015528.1  

    Unigene Cluster for RNF167:

    Ring finger protein 167
    Hs.7158  [show with all ESTs]
    Unigene Representative Sequence: AK025329
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000571816 ENST00000571365 ENST00000573404 ENST00000576452 ENST00000572430
    ENST00000262482(uc002fzs.3 uc002fzu.3) ENST00000570328 ENST00000575111(uc002fzw.2)
    ENST00000576229 ENST00000570492 ENST00000575400 ENST00000572554 ENST00000572382(uc002fzy.3)
    ENST00000576965 ENST00000575524 ENST00000574548
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RNF167 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate RNF167:
    hsa-miR-19b hsa-miR-590-3p hsa-miR-19a
    SwitchGear 3'UTR luciferase reporter plasmidRNF167 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RNF167
    Predesigned siRNA for gene silencing in human, mouse, rat RNF167
    Clone
    Products:
         
    OriGene clones in human, mouse for RNF167 (see all 8)
    OriGene ORF clones in mouse, rat for RNF167
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RNF167 (NM_015528)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNF167
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF167
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RNF167
    OriGene qSTAR qPCR primer pairs in human, mouse for RNF167
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RNF167
      QuantiTect SYBR Green Assays in human, mouse, rat RNF167
      QuantiFast Probe-based Assays in human, mouse, rat RNF167

    Additional mRNA sequence: 

    AK025329.1 AL050060.1 AL079315.1 AL834284.1 AY203930.1 AY960626.1 BC010139.2 BC013222.1 
    CR457340.1 

    Selected DOTS entries (see all 29):

    DT.91759128  DT.100852983  DT.100830162  DT.75173986  DT.100852993  DT.100799467  DT.91759131  DT.100887252 
    DT.95268378  DT.120890914  DT.95268381  DT.40107131  DT.100852982  DT.97860395  DT.100852991  DT.100852998 
    DT.95242193  DT.100830072  DT.120891263  DT.95268384  DT.100852988  DT.95268385  DT.95268395  DT.100852990 

    Selected AceView cDNA sequences (see all 570):

    AA188656 BQ426037 BM451557 F04263 BQ070448 AA609580 BC013222 BM692693 
    BF037516 CB216600 CR593641 AA773096 BU731168 AI523551 BQ070469 F11343 
    CA455405 AA582585 BM848135 CR593443 AA262569 CB120424 BM808855 CA441075 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RNF167 (see all 20)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^
    SP1:                                      -     -     -     -     -     -     -     -                                                     -                     
    SP2:                                                                                                                                      -                     
    SP3:                                                                                                                                      -                     
    SP4:                                                                                                                                      -                     
    SP5:                                      -     -     -                       -                                                           -                     

    ExUns: 12a · 12b · 12c ^ 13a · 13b · 13c
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for RNF167

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    RNF167 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTACCACAG
    RNF167 Expression
    About this image


    RNF167 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Mesoderm (Gastrulation Derivatives)
             Limb Bud Mesenchyme Cells Limb Bud
     
     Limb (Muscoskeletal System)
             Limb Bud Mesenchyme Cells Limb Bud
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
     
     Thyroid (Endocrine System)
    RNF167 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RNF167 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.7158

    UniProtKB/Swiss-Prot: RN167_HUMAN, Q9H6Y7
    Tissue specificity: Strongly expressed in the kidney and liver (at protein level)

        Pathway & Disease-focused RT2 Profiler PCR Arrays including RNF167: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RNF167
    OriGene qSTAR qPCR primer pairs in human, mouse for RNF167
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RNF167
    QuantiTect SYBR Green Assays in human, mouse, rat RNF167
    QuantiFast Probe-based Assays in human, mouse, rat RNF167
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF167

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RNF167 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnf1671 , 5 ring finger protein 1671, 5 90.19(n)1
    94.89(a)1
      11 (43.21 cM)5
    705101  NM_027445.11  NP_081721.11 
     706472355 
    lizard
    (Anolis carolinensis)
    Reptilia RNF1676
    ring finger protein 167
    54(a)
    1 ↔ 1
    GL344987.1(9863-14914)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia rnf1671 ring finger protein 167 61.22(n)
    59.32(a)
      100379947  XM_002943339.2  XP_002943385.2 
    zebrafish
    (Danio rerio)
    Actinopterygii rnf1671 ring finger protein 167 58.2(n)
    55.56(a)
      101055497  XM_005165638.1  XP_005165695.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG102776
    --
    21(a)
    1 → many
    3R(2208633-2214026)
    worm
    (Caenorhabditis elegans)
    Secernentea C18B12.41 C18B12.4 44.73(n)
    34.63(a)
      181600  NM_078097.4  NP_510498.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G226701 AT1G22670 45.36(n)
    38.04(a)
      838873  NM_102114.1  NP_173681.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g01675001 Os03g0167500 45.47(n)
    38.7(a)
      4331745  NM_001055617.1  NP_001049082.1 


    ENSEMBL Gene Tree for RNF167 (if available)
    TreeFam Gene Tree for RNF167 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for RNF167 gene
    ZNRF32  RNF432  RNF1482  RNF1492  RNF1332  RNF1502  RNF1302  RNF2152  
    RNF1282  ZNRF42  RNF132  
    6 SIMAP similar genes for RNF167 using alignment to 8 protein entries:     RN167_HUMAN (see all proteins):
    RNF13    RNF122    ZNRF4    RNF181    RNF24    TRIM3

    Find genes that share paralogs with RNF167           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for RNF167 (see all 127)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1470534241,2
    C--4845707(+) GTCAAC/TGGGTC 2 N syn10--------
    rs1475942121,2
    C,F--4845725(+) ATTGCG/ACTGCT 2 /A syn11Minor allele frequency- A:0.00NA 4550
    rs2008210571,2
    C--4845756(+) TTGACC/TTCAAG 2 L F mis10--------
    rs2382471,2
    C,F,O,A,H--4845768(+) TTGCTG/AAATGA 1 -- int130Minor allele frequency- A:0.40MN NS EA NA WA CSA EU 4176
    rs1996559851,2
    --4845869(+) CTCCCC/TAGGTC 1 -- int10--------
    rs2020461401,2
    C--4845889(+) CAGAAG/TGCTGG 2 K N mis10--------
    rs1490500301,2
    F--4845904(+) GGTGCC/TGCTGT 2 A syn11Minor allele frequency- T:0.00NA 4552
    rs118712321,2
    C,F,H--4846045(+) AGCCAA/GTCCTT 1 -- int112Minor allele frequency- G:0.03NS EA NA 1074
    rs1382358201,2
    C--4846109(+) AGAAG-/GTTGTGAG 1 -- int10--------
    rs2011606091,2
    --4846138(+) TTGATC/TCCTGC 1 -- int10--------

    HapMap Linkage Disequilibrium report for RNF167 (4843303 - 4848517 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for RNF167:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv907621CNV Loss21882294
    nsv907620CNV Loss21882294
    nsv833347CNV Loss17160897
    nsv833350CNV Loss17160897
    nsv833349CNV Loss17160897
    nsv907619CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RNF167
    DNA2.0 Custom Variant and Variant Library Synthesis for RNF167

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 610431    OMIM disorders: --


    Find genes that share disorders with RNF167           About GenesLikeMe


    Export disorders for RNF167 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for RNF167 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with RNF167)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Goliath family E3 ligases regulate the recycling endosome pathway via VAMP3 ubiquitylation. (PubMed id 23353890)1, 3 Yamazaki Y....Palmer R.H. (EMBO J. 2013)
    2. Ubiquitin ligase RNF167 regulates AMPA receptor-mediated synaptic transmission. (PubMed id 23129617)1, 3 Lussier M.P....Roche K.W. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    3. Tumor suppressor candidate TSSC5 is regulated by UbcH6 and a novel ubiquitin ligase RING105. (PubMed id 16314844)1, 2 Yamada H.Y. and Gorbsky G.J. (Oncogene 2006)
    4. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (J. Proteome Res. 2012)
    8. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    9. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 26001 HGNC: 24544 AceView: RNF167 Ensembl:ENSG00000108523 euGenes: HUgn26001
    ECgene: RNF167 H-InvDB: RNF167

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for RNF167 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for RNF167 gene:
    Search GeneIP for patents involving RNF167

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for RNF167  
     OriGene qPCR primer pairs and template standards for RNF167   OriGene Protein Over-expression Lysate for RNF167  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for RNF167  
     OriGene qSTAR qPCR primer pairs in human, mouse for RNF167   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for RNF167   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RNF167   OriGene Custom Protein Services for RNF167  

     
     
     Block miRNA regulation of human, mouse, rat RNF167 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing RNF167
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNF167 Predesigned siRNA for gene silencing in human, mouse, rat RNF167
     QuantiFast Probe-based Assays in human, mouse, rat RNF167 QuantiTect SYBR Green Assays in human, mouse, rat RNF167
     PCR Arrays including human, mouse, rat RNF167 Search Chromatin IP Primers for RNF167
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RNF167  Search GeneGlobe Interaction Network for RNF167
     Regulatory tfbs in RNF167 promoter
     GenScript Custom Purified and Recombinant Proteins Services for RNF167 GenScript cDNA clones with any tag delivered in your preferred vector for RNF167
     GenScript Custom Assay Services for RNF167 GenScript Custom overexpressing Cell Line Services for RNF167
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for RNF167 (RN167)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for RNF167
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     RNF167 antibodies
     RNF167 proteins
     RNF167 lysates
     Antibodies for RNF167
     See all of Abcam's Antibodies, Kits and Proteins for RNF167
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for RNF167
     Antibodies for RNF167
     ELISAs for RNF167
     CLIAs for RNF167



     Browse ESI BIO Cell Lines and PureStem Progenitors for RNF167
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF167
     SwitchGear 3'UTR luciferase reporter plasmids for RNF167
     SwitchGear Promoter luciferase reporter plasmids for RNF167
     Search ThermoFisher Antibodies for RNF167
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF167
     Browse compounds at ApexBio
     Search Addgene for plasmids for RNF167
      Search eBioscience for proteins for RNF167
      Search eBioscience for elisas for RNF167
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for RNF167
     antibodies-online antibodies for RNF167 (17 products)
     antibodies-online kits for RNF167 (6 products)
     antibodies-online peptides for RNF167
     antibodies-online proteins for RNF167 (4 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RNF167 gene at Home site.
    Version: 3.12.250 16 Nov 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4