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Aliases for RNF167 Gene

Aliases for RNF167 Gene

  • Ring Finger Protein 167 2 3
  • RING105 3 4 6
  • E3 Ubiquitin-Protein Ligase RNF167 3
  • RING Finger Protein 167 4
  • 5730408C10Rik 3
  • EC 6.3.2.- 4
  • LP2254 3

External Ids for RNF167 Gene

Previous GeneCards Identifiers for RNF167 Gene

  • GC17P004784
  • GC17P004845

Summaries for RNF167 Gene

Entrez Gene Summary for RNF167 Gene

  • RNF167 is an E3 ubiquitin ligase that interacts with TSSC5 (SLC22A18; MIM 602631) and, together with UBCH6 (UBE2E1; MIM 602916), facilitates TSSC5 polyubiquitylation (Yamada and Gorbsky, 2006 [PubMed 16314844]).[supplied by OMIM, Mar 2008]

GeneCards Summary for RNF167 Gene

RNF167 (Ring Finger Protein 167) is a Protein Coding gene. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is RNF215.

UniProtKB/Swiss-Prot for RNF167 Gene

  • May act as an E3 ubiquitin-protein ligase, or as part of the E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2E1, and then transfers it to substrates, such as SLC22A18. May play a role in growth regulation involved in G1/S transition.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF167 Gene

Genomics for RNF167 Gene

Regulatory Elements for RNF167 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RNF167 Gene

Start:
4,940,008 bp from pter
End:
4,945,222 bp from pter
Size:
5,215 bases
Orientation:
Plus strand

Genomic View for RNF167 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNF167 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF167 Gene

Proteins for RNF167 Gene

  • Protein details for RNF167 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H6Y7-RN167_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase RNF167
    Protein Accession:
    Q9H6Y7
    Secondary Accessions:
    • D3DTK8
    • Q6XYE0
    • Q8NDC1
    • Q9Y3V1

    Protein attributes for RNF167 Gene

    Size:
    350 amino acids
    Molecular mass:
    38299 Da
    Quaternary structure:
    • Interacts with SLC22A18.
    SequenceCaution:
    • Sequence=AAP34453.1; Type=Frameshift; Positions=65; Evidence={ECO:0000305};

neXtProt entry for RNF167 Gene

Proteomics data for RNF167 Gene at MOPED

Post-translational modifications for RNF167 Gene

  • Auto-ubiquitinated in vitro in the presence of UBE2D1 and UBE2E1.
  • Ubiquitination at Lys97, Lys210, Lys214, Lys223, and Lys272
  • Glycosylation at Asn79
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RNF167 Gene

Domains for RNF167 Gene

Gene Families for RNF167 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for RNF167 Gene

Suggested Antigen Peptide Sequences for RNF167 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H6Y7

UniProtKB/Swiss-Prot:

RN167_HUMAN :
  • Q9H6Y7
Domain:
  • Contains 1 PA (protease associated) domain.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF167: view

Function for RNF167 Gene

Molecular function for RNF167 Gene

UniProtKB/Swiss-Prot Function: May act as an E3 ubiquitin-protein ligase, or as part of the E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2E1, and then transfers it to substrates, such as SLC22A18. May play a role in growth regulation involved in G1/S transition.

Enzyme Numbers (IUBMB) for RNF167 Gene

Gene Ontology (GO) - Molecular Function for RNF167 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 16314844
GO:0005515 protein binding IPI 16314844
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with RNF167: view

Animal Model Products

CRISPR Products

miRNA for RNF167 Gene

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RNF167 Gene

Localization for RNF167 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF167 Gene

Endomembrane system; Single-pass membrane protein. Note=Targeted to cytoplasmic membranes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNF167 Gene COMPARTMENTS Subcellular localization image for RNF167 gene
Compartment Confidence
plasma membrane 2
endoplasmic reticulum 1
endosome 1
extracellular 1
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for RNF167 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 16314844
GO:0012505 endomembrane system IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RNF167: view

Pathways for RNF167 Gene

SuperPathways for RNF167 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Ubiquitin Ligases in human,mouse,rat
    • Ubiquitination (Ubiquitylation) Pathway in human,mouse,rat

UniProtKB/Swiss-Prot Q9H6Y7-RN167_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for RNF167 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IDA 16314844
GO:0045786 negative regulation of cell cycle IMP 16314844
genes like me logo Genes that share ontologies with RNF167: view

No data available for Pathways by source for RNF167 Gene

Transcripts for RNF167 Gene

Unigene Clusters for RNF167 Gene

Ring finger protein 167:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNF167

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF167 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^
SP1: - - - - - - - - -
SP2: -
SP3: -
SP4: -
SP5: - - - - -
SP6: - -
SP7: - - -
SP8: - - - - - - -
SP9:
SP10: - - - -
SP11: - - - - -
SP12: - - - -
SP13: -
SP14: - - - - -
SP15: - - -
SP16:
SP17: - -
SP18: - -
SP19: - - - - - -
SP20:

ExUns: 12a · 12b · 12c ^ 13a · 13b · 13c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:

Relevant External Links for RNF167 Gene

GeneLoc Exon Structure for
RNF167
ECgene alternative splicing isoforms for
RNF167

Expression for RNF167 Gene

mRNA expression in normal human tissues for RNF167 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNF167 Gene

This gene is overexpressed in Whole Blood (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RNF167 Gene

SOURCE GeneReport for Unigene cluster for RNF167 Gene Hs.7158

mRNA Expression by UniProt/SwissProt for RNF167 Gene

Q9H6Y7-RN167_HUMAN
Tissue specificity: Strongly expressed in the kidney and liver (at protein level).
genes like me logo Genes that share expressions with RNF167: view

In Situ Assay Products

Orthologs for RNF167 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RNF167 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNF167 35
  • 99.62 (n)
  • 99.43 (a)
RNF167 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 74 (a)
OneToMany
RNF167 35
  • 92.99 (n)
  • 94.89 (a)
RNF167 36
  • 94 (a)
OneToMany
dog
(Canis familiaris)
Mammalia RNF167 36
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnf167 35
  • 90.19 (n)
  • 94.89 (a)
Rnf167 16
Rnf167 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RNF167 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RNF167 36
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnf167 35
  • 89.19 (n)
  • 94.59 (a)
lizard
(Anolis carolinensis)
Reptilia RNF167 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf167 35
  • 61.22 (n)
  • 59.32 (a)
zebrafish
(Danio rerio)
Actinopterygii rnf167 35
  • 58.2 (n)
  • 55.56 (a)
rnf167 36
  • 44 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG10277 36
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C18B12.4 35
  • 44.73 (n)
  • 34.63 (a)
C18B12.4 36
  • 21 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G22670 35
  • 45.36 (n)
  • 38.04 (a)
rice
(Oryza sativa)
Liliopsida Os03g0167500 35
  • 45.47 (n)
  • 38.7 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.598 36
  • 30 (a)
OneToMany
Species with no ortholog for RNF167:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RNF167 Gene

ENSEMBL:
Gene Tree for RNF167 (if available)
TreeFam:
Gene Tree for RNF167 (if available)

Paralogs for RNF167 Gene

Selected SIMAP similar genes for RNF167 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with RNF167: view

Variants for RNF167 Gene

Sequence variations from dbSNP and Humsavar for RNF167 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs238245 -- 4,944,148(+) AGGGA(C/T)AGACT intron-variant
rs238246 -- 4,944,061(+) TTCTG(C/T)TTTTA intron-variant
rs238247 -- 4,942,473(+) TTGCT(A/G)AATGA intron-variant
rs1043815 -- 4,945,013(+) CTGGT(C/T)TAATA reference, synonymous-codon
rs1043840 -- 4,945,033(+) ACATA(A/C)ACCTC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RNF167 Gene

Variant ID Type Subtype PubMed ID
nsv833347 CNV Loss 17160897
nsv833349 CNV Loss 17160897
nsv907619 CNV Loss 21882294
nsv907620 CNV Loss 21882294
nsv833350 CNV Loss 17160897
nsv907621 CNV Loss 21882294

Relevant External Links for RNF167 Gene

HapMap Linkage Disequilibrium report
RNF167

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF167 Gene

Disorders for RNF167 Gene

No disorders were found for RNF167 Gene.

No data available for UniProtKB/Swiss-Prot for RNF167 Gene

Publications for RNF167 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D. … Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  4. Tumor suppressor candidate TSSC5 is regulated by UbcH6 and a novel ubiquitin ligase RING105. (PMID: 16314844) Yamada H.Y. … Gorbsky G.J. (Oncogene 2006) 3 4
  5. Ubiquitin ligase RNF167 regulates AMPA receptor-mediated synaptic transmission. (PMID: 23129617) Lussier M.P. … Roche K.W. (Proc. Natl. Acad. Sci. U.S.A. 2012) 2 3

Products for RNF167 Gene

Sources for RNF167 Gene

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