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Aliases for RNF166 Gene

Aliases for RNF166 Gene

  • Ring Finger Protein 166 2 3 5

External Ids for RNF166 Gene

Previous GeneCards Identifiers for RNF166 Gene

  • GC16M088508
  • GC16M087290
  • GC16M088762
  • GC16M074457

Summaries for RNF166 Gene

GeneCards Summary for RNF166 Gene

RNF166 (Ring Finger Protein 166) is a Protein Coding gene. An important paralog of this gene is RNF114.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF166 Gene

Genomics for RNF166 Gene

Regulatory Elements for RNF166 Gene

Enhancers for RNF166 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RNF166 on UCSC Golden Path with GeneCards custom track

Promoters for RNF166 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RNF166 on UCSC Golden Path with GeneCards custom track

Genomic Location for RNF166 Gene

88,696,495 bp from pter
88,706,421 bp from pter
9,927 bases
Minus strand

Genomic View for RNF166 Gene

Genes around RNF166 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF166 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF166 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF166 Gene

Proteins for RNF166 Gene

  • Protein details for RNF166 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RING finger protein 166
    Protein Accession:
    Secondary Accessions:
    • B3KQ03
    • D3DX75
    • H3BTU8
    • Q96DM0

    Protein attributes for RNF166 Gene

    237 amino acids
    Molecular mass:
    26122 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RNF166 Gene


neXtProt entry for RNF166 Gene

Proteomics data for RNF166 Gene at MOPED

Post-translational modifications for RNF166 Gene

  • Ubiquitination at Lys 129 and Lys 167
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RNF166 Gene

Domains & Families for RNF166 Gene

Gene Families for RNF166 Gene

Suggested Antigen Peptide Sequences for RNF166 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 UIM (ubiquitin-interacting motif) domain.
  • Contains 1 RING-type zinc finger.
  • Contains 1 UIM (ubiquitin-interacting motif) domain.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF166: view

Function for RNF166 Gene

Gene Ontology (GO) - Molecular Function for RNF166 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0061630 ubiquitin protein ligase activity IBA --
genes like me logo Genes that share ontologies with RNF166: view

Phenotypes for RNF166 Gene

genes like me logo Genes that share phenotypes with RNF166: view

Animal Model Products

miRNA for RNF166 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNF166 Gene

Localization for RNF166 Gene

Subcellular locations from

Jensen Localization Image for RNF166 Gene COMPARTMENTS Subcellular localization image for RNF166 gene
Compartment Confidence
nucleus 4
cytosol 2
plasma membrane 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RNF166 Gene

Pathways & Interactions for RNF166 Gene

SuperPathways for RNF166 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RNF166 Gene


No data available for Pathways by source and SIGNOR curated interactions for RNF166 Gene

Drugs & Compounds for RNF166 Gene

No Compound Related Data Available

Transcripts for RNF166 Gene

Unigene Clusters for RNF166 Gene

Ring finger protein 166:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNF166 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d
SP1: - - - - - - - -
SP2: - - - - - - - -
SP3: - - - -
SP4: - -
SP7: - -

Relevant External Links for RNF166 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNF166 Gene

mRNA expression in normal human tissues for RNF166 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNF166 Gene

This gene is overexpressed in Whole Blood (x12.9).

Protein differential expression in normal tissues from HIPED for RNF166 Gene

This gene is overexpressed in Neutrophil (46.1), Peripheral blood mononuclear cells (12.3), and Blymphocyte (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RNF166 Gene

SOURCE GeneReport for Unigene cluster for RNF166 Gene Hs.513804

genes like me logo Genes that share expression patterns with RNF166: view

Protein tissue co-expression partners for RNF166 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for RNF166 Gene

Orthologs for RNF166 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNF166 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RNF166 35
  • 91.28 (n)
  • 94.51 (a)
RNF166 36
  • 95 (a)
(Canis familiaris)
Mammalia RNF166 35
  • 90.01 (n)
  • 94.94 (a)
RNF166 36
  • 95 (a)
(Mus musculus)
Mammalia Rnf166 35
  • 91.14 (n)
  • 98.73 (a)
Rnf166 16
Rnf166 36
  • 99 (a)
(Pan troglodytes)
Mammalia RNF166 35
  • 99.72 (n)
  • 100 (a)
RNF166 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Rnf166 35
  • 90.15 (n)
  • 98.73 (a)
(Monodelphis domestica)
Mammalia RNF166 36
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia RNF166 36
  • 86 (a)
(Gallus gallus)
Aves RNF166 35
  • 83.69 (n)
  • 86.7 (a)
RNF166 36
  • 91 (a)
(Anolis carolinensis)
Reptilia RNF166 36
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf166 35
  • 77.12 (n)
  • 89.41 (a)
(Danio rerio)
Actinopterygii LOC100334524 35
  • 75.81 (n)
  • 83.12 (a)
RNF166 (1 of 2) 36
  • 89 (a)
RNF166 (2 of 2) 36
  • 82 (a)
Species with no ortholog for RNF166:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF166 Gene

Gene Tree for RNF166 (if available)
Gene Tree for RNF166 (if available)

Paralogs for RNF166 Gene

Paralogs for RNF166 Gene

(7) SIMAP similar genes for RNF166 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with RNF166: view

Variants for RNF166 Gene

Sequence variations from dbSNP and Humsavar for RNF166 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs13556 -- 88,696,743(+) GCCCC(A/G)CCTCT utr-variant-3-prime
rs4489989 -- 88,703,257(+) ATTGT(G/T)GCATA intron-variant, utr-variant-5-prime
rs4597303 -- 88,697,153(+) GGAAG(C/T)GGGGC utr-variant-3-prime
rs4782318 -- 88,702,992(+) GGATG(A/G)AGAGA intron-variant, utr-variant-5-prime
rs4782425 -- 88,701,060(+) CCCCC(C/T)GTCAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RNF166 Gene

Variant ID Type Subtype PubMed ID
nsv907226 CNV Loss 21882294
nsv907255 CNV Loss 21882294
nsv833325 CNV Loss 17160897
nsv907268 CNV Loss 21882294
dgv2977n71 CNV Loss 21882294
dgv2978n71 CNV Loss 21882294
dgv2979n71 CNV Loss 21882294
nsv907278 CNV Loss 21882294
nsv907283 CNV Loss 21882294
dgv2981n71 CNV Loss 21882294
nsv471113 CNV Loss 18288195
nsv833327 CNV Loss 17160897
dgv2982n71 CNV Loss 21882294
dgv2983n71 CNV Loss 21882294
nsv907296 CNV Loss 21882294
dgv2984n71 CNV Loss 21882294
nsv471114 CNV Gain 18288195
dgv2985n71 CNV Loss 21882294
nsv907300 CNV Gain 21882294
nsv827833 CNV Gain 20364138
nsv907305 CNV Loss 21882294

Variation tolerance for RNF166 Gene

Residual Variation Intolerance Score: 76.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.41; 8.92% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RNF166 Gene

Disorders for RNF166 Gene

Relevant External Links for RNF166

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RNF166 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF166 Gene

Publications for RNF166 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. A genome-wide association study of autism using the Simons Simplex Collection: Does reducing phenotypic heterogeneity in autism increase genetic homogeneity? (PMID: 25534755) Chaste P. … Devlin B. (Biol. Psychiatry 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Ring finger protein 166 potentiates RNA virus-induced interferon-I^ production via enhancing the ubiquitination of TRAF3 and TRAF6. (PMID: 26456228) Chen H.W. … Chen D.Y. (Sci Rep 2015) 3

Products for RNF166 Gene

Sources for RNF166 Gene