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Aliases for RNF166 Gene

Aliases for RNF166 Gene

  • Ring Finger Protein 166 2 3 5

External Ids for RNF166 Gene

Previous GeneCards Identifiers for RNF166 Gene

  • GC16M088508
  • GC16M087290
  • GC16M088762
  • GC16M074457

Summaries for RNF166 Gene

GeneCards Summary for RNF166 Gene

RNF166 (Ring Finger Protein 166) is a Protein Coding gene. An important paralog of this gene is RNF114.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF166 Gene

Genomics for RNF166 Gene

Regulatory Elements for RNF166 Gene

Enhancers for RNF166 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F088698 1.6 FANTOM5 ENCODE 37.5 +3.6 3590 9.4 MLX CREB3L1 FEZF1 DMAP1 ZNF143 ZNF263 SP3 NFYC TBX21 MEF2D RNF166 CTU2 SNAI3-AS1 SNAI3 ZNF778 ENSG00000260121 PIEZO1 CDK10 ZC3H18 APRT
GH16F088452 1.5 FANTOM5 ENCODE 16.1 +251.5 251485 6.0 HDGF PKNOX1 ARNT MLX WRNIP1 ARID4B SIN3A DMAP1 YBX1 ZNF2 ENSG00000259877 RNF166 CTU2 TRAPPC2L ZFPM1 LOC100289580 ENSG00000268218 ENSG00000260121 ZCCHC14 ZC3H18
GH16F088690 1.2 Ensembl ENCODE 14.8 +14.2 14221 4.0 PKNOX1 MLX ARID4B DMAP1 ZNF48 SLC30A9 ZNF121 SP5 MXD4 ZHX2 RNF166 SNAI3-AS1 MVD CYBA PIEZO1 ENSG00000259813 ENSG00000280603
GH16F088633 1.7 FANTOM5 Ensembl ENCODE 9.6 +70.8 70799 4.9 HDGF PKNOX1 ARNT MLX ARID4B SIN3A DMAP1 ZNF143 ZNF207 ZNF263 CYBA CTU2 ENSG00000259877 RNF166 ZC3H18 SNAI3 CBFA2T3 ZFPM1 ACSF3 IL17C
GH16F089112 1.7 FANTOM5 Ensembl ENCODE 8.8 -412.0 -412018 11.3 HDGF PKNOX1 CREB3L1 ARNT MLX ZFP64 ARID4B SIN3A DMAP1 FOS ACSF3 ENSG00000259877 CTU2 TRAPPC2L GALNS RNF166 TUBB3 CYBA SNAI3 ENSG00000260279
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RNF166 on UCSC Golden Path with GeneCards custom track

Promoters for RNF166 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for RNF166 Gene

88,696,495 bp from pter
88,706,421 bp from pter
9,927 bases
Minus strand

Genomic View for RNF166 Gene

Genes around RNF166 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF166 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF166 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF166 Gene

Proteins for RNF166 Gene

  • Protein details for RNF166 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RING finger protein 166
    Protein Accession:
    Secondary Accessions:
    • B3KQ03
    • D3DX75
    • H3BTU8
    • Q96DM0

    Protein attributes for RNF166 Gene

    237 amino acids
    Molecular mass:
    26122 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RNF166 Gene


neXtProt entry for RNF166 Gene

Post-translational modifications for RNF166 Gene

  • Ubiquitination at Lys 129 and Lys 167
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RNF166 Gene

Domains & Families for RNF166 Gene

Gene Families for RNF166 Gene

Suggested Antigen Peptide Sequences for RNF166 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 UIM (ubiquitin-interacting motif) domain.
  • Contains 1 C2HC RNF-type zinc finger.
  • Contains 1 UIM (ubiquitin-interacting motif) domain.
  • Contains 1 C2HC RNF-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF166: view

Function for RNF166 Gene

Gene Ontology (GO) - Molecular Function for RNF166 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0031624 ubiquitin conjugating enzyme binding IBA --
GO:0046872 metal ion binding IEA --
GO:0061630 ubiquitin protein ligase activity IBA --
genes like me logo Genes that share ontologies with RNF166: view

Phenotypes for RNF166 Gene

genes like me logo Genes that share phenotypes with RNF166: view

Animal Model Products

miRNA for RNF166 Gene

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNF166 Gene

Localization for RNF166 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNF166 gene
Compartment Confidence
nucleus 4
plasma membrane 2
cytosol 2

Gene Ontology (GO) - Cellular Components for RNF166 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IBA --
genes like me logo Genes that share ontologies with RNF166: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RNF166 Gene

Pathways & Interactions for RNF166 Gene

SuperPathways for RNF166 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RNF166 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IBA --
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA --
genes like me logo Genes that share ontologies with RNF166: view

No data available for Pathways by source and SIGNOR curated interactions for RNF166 Gene

Transcripts for RNF166 Gene

Unigene Clusters for RNF166 Gene

Ring finger protein 166:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF166 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d
SP1: - - - - - - - -
SP2: - - - - - - - -
SP3: - - - -
SP4: - -
SP7: - -

Relevant External Links for RNF166 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNF166 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RNF166 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNF166 Gene

This gene is overexpressed in Whole Blood (x12.9).

Protein differential expression in normal tissues from HIPED for RNF166 Gene

This gene is overexpressed in Neutrophil (46.1), Peripheral blood mononuclear cells (12.3), and Blymphocyte (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RNF166 Gene

Protein tissue co-expression partners for RNF166 Gene

NURSA nuclear receptor signaling pathways regulating expression of RNF166 Gene:


SOURCE GeneReport for Unigene cluster for RNF166 Gene:

genes like me logo Genes that share expression patterns with RNF166: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for RNF166 Gene

Orthologs for RNF166 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNF166 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RNF166 34 35
  • 99.72 (n)
(Bos Taurus)
Mammalia RNF166 34 35
  • 91.28 (n)
(Mus musculus)
Mammalia Rnf166 34 16 35
  • 91.14 (n)
(Rattus norvegicus)
Mammalia Rnf166 34
  • 90.15 (n)
(Canis familiaris)
Mammalia RNF166 34 35
  • 90.01 (n)
(Monodelphis domestica)
Mammalia RNF166 35
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia RNF166 35
  • 86 (a)
(Gallus gallus)
Aves RNF166 34 35
  • 83.69 (n)
(Anolis carolinensis)
Reptilia RNF166 35
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf166 34
  • 77.12 (n)
(Danio rerio)
Actinopterygii RNF166 (1 of 2) 35
  • 89 (a)
RNF166 (2 of 2) 35
  • 82 (a)
LOC100334524 34
  • 75.81 (n)
Species where no ortholog for RNF166 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF166 Gene

Gene Tree for RNF166 (if available)
Gene Tree for RNF166 (if available)

Paralogs for RNF166 Gene

Paralogs for RNF166 Gene

(7) SIMAP similar genes for RNF166 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with RNF166: view

Variants for RNF166 Gene

Sequence variations from dbSNP and Humsavar for RNF166 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1052947 -- 88,701,346(-) CCCTT(C/T)GACCC intron-variant, upstream-variant-2KB, reference, synonymous-codon, utr-variant-5-prime
rs11076700 -- 88,697,550(-) CCACC(C/T)GCCTG utr-variant-3-prime
rs11076701 -- 88,708,117(+) CCAAG(A/G)TAGGT intron-variant, upstream-variant-2KB
rs11076702 -- 88,708,161(+) CCAAG(A/C)ACACC intron-variant, upstream-variant-2KB
rs111472033 -- 88,705,113(+) GCGTG(A/G)GCAGG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RNF166 Gene

Variant ID Type Subtype PubMed ID
nsv952070 CNV deletion 24416366
nsv833327 CNV loss 17160897
nsv833325 CNV loss 17160897
nsv827833 CNV gain 20364138
nsv482951 CNV loss 15286789
nsv471114 CNV gain 18288195
nsv471113 CNV loss 18288195
nsv1121921 CNV deletion 24896259
nsv1065973 CNV loss 25217958
dgv3064n100 CNV gain 25217958

Variation tolerance for RNF166 Gene

Residual Variation Intolerance Score: 76.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.41; 8.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNF166 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF166 Gene

Disorders for RNF166 Gene

Relevant External Links for RNF166

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RNF166 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF166 Gene

Publications for RNF166 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. A genome-wide association study of autism using the Simons Simplex Collection: Does reducing phenotypic heterogeneity in autism increase genetic homogeneity? (PMID: 25534755) Chaste P. … Devlin B. (Biol. Psychiatry 2015) 3 64
  5. The melanoma-associated antigen 1 (MAGEA1) protein stimulates the E3 ubiquitin-ligase activity of TRIM31 within a TRIM31-MAGEA1-NSE4 complex. (PMID: 25590999) Kozakova L. … Palecek J.J. (Cell Cycle 2015) 3 64

Products for RNF166 Gene

Sources for RNF166 Gene

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