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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RNF166 Gene

protein-coding   GIFtS: 46
GCID: GC16M088762

Ring Finger Protein 166

  Search for RNF166
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ring Finger Protein 1661 2

External Ids:    HGNC: 288561   Entrez Gene: 1159922   Ensembl: ENSG000001587177   UniProtKB: Q96A373   

Export aliases for RNF166 gene to outside databases

Previous GC identifers: GC16M088508 GC16M087290 GC16M074457


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RNF166 Gene: 
RNF166 (ring finger protein 166) is a protein-coding gene. GO annotations related to this gene include zinc ion binding. An important paralog of this gene is RNF125.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010542.15  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RNF166 gene promoter:
         GR   Pax-5   Olf-1   Tal-1beta   E47   CREB   deltaCREB   GR-alpha   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNF166 promoter sequence
   Search SABiosciences Chromatin IP Primers for RNF166

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF166


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q24.3   Ensembl cytogenetic band:  16q24.3   HGNC cytogenetic band: 16q24.3

RNF166 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF166 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M088762:  view genomic region     (about GC identifiers)

Start:
88,762,903 bp from pter      End:
88,772,829 bp from pter
Size:
9,927 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RN166_HUMAN, Q96A37 (See protein sequence)
Recommended Name: RING finger protein 166  
Size: 237 amino acids; 26122 Da
Secondary accessions: B3KQ03 D3DX75 H3BTU8 Q96DM0
Alternative splicing: 3 isoforms:  Q96A37-1   Q96A37-2   Q96A37-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RNF166: NX_Q96A37

Explore proteomics data for RNF166 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96A37

  • RNF166 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RNF166 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001165286.1  NP_001165287.1  NP_849163.1  

    ENSEMBL proteins: 
     ENSP00000326095   ENSP00000455617   ENSP00000455539   ENSP00000446301   ENSP00000440454  
     ENSP00000457374   ENSP00000457336  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RNF: RING-type (C3HC4) zinc fingers

    5 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR008598 Di19_RING_finger_144
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q96A37

    ProtoNet protein and cluster: Q96A37

    2 Blocks protein domains:
    IPB001841 Zn-finger
    IPB003903 Ubiquitin interacting motif


    UniProtKB/Swiss-Prot: RN166_HUMAN, Q96A37
    Similarity: Contains 1 RING-type zinc finger
    Similarity: Contains 1 UIM (ubiquitin-interacting motif) repeat


    RNF166 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0046872metal ion binding ----
         
    RNF166 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for RNF166:
     Increased cell death HMECs cel  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RNF166 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RNF166

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    SwitchGear 3'UTR luciferase reporter plasmidRNF166 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNF166

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/18 Interacting proteins for RNF166 (Q96A373 ENSP000003260954) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE2D2P628373, ENSP000003817174I2D: score=2 STRING: ENSP00000381717
    UBE2D3P610773, ENSP000003497224I2D: score=2 STRING: ENSP00000349722
    UBE2UQ5VVX93, ENSP000003601164I2D: score=2 STRING: ENSP00000360116
    UBE2WQ96B023, ENSP000003974534I2D: score=2 STRING: ENSP00000397453
    UBE2D1P516683, ENSP000003630194I2D: score=2 STRING: ENSP00000363019
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RNF166 (RN166)

    Search CenterWatch for drugs/clinical trials and news about RNF166 / RN166

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RNF166 gene (3 alternative transcripts): 
    NM_001171815.1  NM_001171816.1  NM_178841.3  

    Unigene Cluster for RNF166:

    Ring finger protein 166
    Hs.513804  [show with all ESTs]
    Unigene Representative Sequence: NM_001171816
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000312838(uc021tmo.1 uc002flk.3) ENST00000567408 ENST00000562544
    ENST00000537718 ENST00000541206(uc021tmn.1) ENST00000565083 ENST00000568683
    ENST00000567844 ENST00000564894 ENST00000562499 ENST00000569478
    miRNA
    Products:
         
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    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate RNF166 (see all 17):
    hsa-miR-25 hsa-miR-575 hsa-miR-624* hsa-miR-3190 hsa-miR-511 hsa-miR-548c-3p hsa-miR-92b hsa-miR-384
    SwitchGear 3'UTR luciferase reporter plasmidRNF166 3' UTR sequence
    Inhib. RNA
    Products:
         
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNF166

    Additional mRNA sequence: 

    AK026860.1 AK057106.1 AK057201.1 AK290920.1 BC013948.2 BC017226.1 

    13 DOTS entries:

    DT.107949  DT.95070030  DT.100782577  DT.91947399  DT.100654430  DT.91850458  DT.100782581  DT.91936004 
    DT.100665280  DT.100782578  DT.100782582  DT.75157380  DT.95070037 

    24/108 AceView cDNA sequences (see all 108):

    BX280868 BI489894 CR596749 BE312288 CR598819 CR620092 CR612154 AK057106 
    BM906320 BQ073037 CD557843 BE379210 BG830046 AK057201 BE798954 CD368225 
    BF512191 BU856178 NM_178841 BQ440544 BQ068333 BI825608 AI936723 BX374435 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for RNF166 (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d
    SP1:        -     -     -     -     -                       -     -                             -                           
    SP2:        -     -     -     -     -                       -     -                             -                           
    SP3:                                -                       -     -                             -                           
    SP4:                                                              -                             -                           
    SP5:                                                                                                                        


    ECgene alternative splicing isoforms for RNF166

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RNF166 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGTCTGCTG
    RNF166 Expression
    About this image


    See RNF166 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RNF166

    SOURCE GeneReport for Unigene cluster: Hs.513804
        SABiosciences Expression via Pathway-Focused PCR Array including RNF166: 
              Ubiquitin Ligases in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for RNF166 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnf1661 , 5 ring finger protein 1661, 5 91.14(n)1
    98.73(a)1
      8 (71.17 cM)5
    687181  NM_001033142.21  NP_001028314.11 
     1224661475 
    chicken
    (Gallus gallus)
    Aves RNF1661 ring finger protein 166 83.69(n)
    86.7(a)
      425360  NM_001012935.1  NP_001012953.1 
    lizard
    (Anolis carolinensis)
    Reptilia RNF1666
    Uncharacterized protein
    74(a)
    1 ↔ 1
    GL343670.1(150179-158943)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003345241 RING finger protein 166-like 75.81(n)
    83.12(a)
      100334524  XM_002662942.1  XP_002662988.1 


    ENSEMBL Gene Tree for RNF166 (if available)
    TreeFam Gene Tree for RNF166 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RNF166 gene
    RNF1252  RNF1382  RNF1142  
    8 SIMAP similar genes for RNF166 using alignment to 4 protein entries:     RN166_HUMAN (see all proteins):
    ZNF313    RNF114    TRIM17    TRIM5    BRCA1    TRIM39
    RNF4    TRIM60

    RNF166 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/296 SNPs in RNF166 are shown (see all 296)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1388708581,2
    --88762416(+) CTGGAA/GAACAG 3 -- int10--------
    rs751421001,2
    C,F--88762449(+) GGCCCC/GTCAGA 3 -- int11Minor allele frequency- G:0.04EA 120
    rs732605971,2
    C,F--88762457(+) AGAGAA/GCTACA 3 -- int12Minor allele frequency- G:0.18WA 120
    rs1151036651,2
    C,F--88762473(+) TTAGTG/CTAACA 3 -- int12Minor allele frequency- C:0.02WA EA 238
    rs1143231611,2
    C,F--88762504(+) ATCCAG/AGAGGT 3 -- int11Minor allele frequency- A:0.03WA 118
    rs118635971,2
    C,F,H--88762506(+) CCAGGA/CGGTGC 3 -- int19Minor allele frequency- C:0.26NA WA CSA 252
    rs1413100651,2
    --88762544(+) TGACAC/TGGGAG 3 -- int10--------
    rs1502245991,2
    --88762545(+) GACACA/GGGAGG 3 -- int10--------
    rs356394681,2
    C--88762933(+) TAAACT/-TTTTT 3 -- ut311Minor allele frequency- -:0.00NA 2
    rs11325791,2
    C,F,A,H--88762943(-) TTTTTT/AAAAAA 3 -- ut31 trp34Minor allele frequency- A:0.50NA WA 10

    HapMap Linkage Disequilibrium report for RNF166 (88762903 - 88772829 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/21 variations for RNF166 (see all 21):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833327CNV Loss17160897
    nsv907278CNV Loss21882294
    nsv907268CNV Loss21882294
    nsv907226CNV Loss21882294
    nsv833325CNV Loss17160897
    dgv2981n71CNV Loss21882294
    nsv907296CNV Loss21882294
    nsv907283CNV Loss21882294
    nsv471113CNV Loss18288195
    nsv907305CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing RNF166
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RNF166 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with RNF166)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    4. Systematic analysis of dimeric E3-RING interactions re veals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)1 Woodsmith J....Sanderson C.M. (2012)
    5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    6. Direct and indirect control of mitogen-activated prote in kinase pathway-associated components, BRAP/IMP E3 ubiquitin ligase and CRAF/R AF1 kinase, by the deubiquitylating enzyme USP15. (PubMed id 23105109)1 Hayes S.D....Urbe S. (2012)
    7. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. (PubMed id 19549727)1 Markson G....Sanderson C.M. (2009)
    10. A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. (PubMed id 19690564)1 van Wijk S.J....Timmers H.T. (2009)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 115992 HGNC: 28856 AceView: RNF166 Ensembl:ENSG00000158717 euGenes: HUgn115992
    ECgene: RNF166 H-InvDB: RNF166

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RNF166 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RNF166 gene:
    Search GeneIP for patents involving RNF166

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