RNF166 Gene
protein-coding GIFtS: 45
GCID: GC16M088762
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|
ring finger protein 166
| |
Aliases
for RNF166 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ring Finger Protein 1661 2 | | MGC143811 | | MGC26471 |
Export aliases for RNF166 gene to outside databasesPrevious GC identifers: GC16M088508 GC16M087290 GC16M074457 |
Summaries
for RNF166 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for RNF166 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010542.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RNF166 gene promoter:
GR Pax-5 Olf-1 Tal-1beta E47 CREB deltaCREB GR-alpha ITF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for RNF166
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF166 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16q24.3 Ensembl cytogenetic band: 16q24.3 HGNC cytogenetic band: 16q24.3RNF166 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M088762: view genomic region
(about GC identifiers)
Start:
|
88,762,903 bp from pter |
End:
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88,772,829 bp from pter |
Size:
|
9,927 bases |
Orientation:
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minus strand |
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Proteins
for RNF166 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RN166_HUMAN, Q96A37 (See
protein sequence)Recommended Name: RING finger protein 166 Size: 237 amino acids; 26122 Da
Secondary accessions: B3KQ03 D3DX75 H3BTU8 Q96DM0Alternative splicing: 3 isoforms: Q96A37-1 Q96A37-2 Q96A37-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for RNF166: NX_Q96A37
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96A37
RNF166 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001165286.1 NP_001165287.1 NP_849163.1
ENSEMBL proteins: ENSP00000326095 ENSP00000455617 ENSP00000455539 ENSP00000446301 ENSP00000440454 ENSP00000457374 ENSP00000457336
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
IEA | -- |
RNF166 for ontologies About GeneDecksing
RNF166 Antibody Products:
Assay Products for RNF166: |
Protein
Domains /
Families
for RNF166 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RNF166 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96A37ProtoNet protein and cluster: Q96A37 2 Blocks protein families: IPB001841 Zn-finger IPB003903 Ubiquitin interacting motif
UniProtKB/Swiss-Prot: RN166_HUMAN, Q96A37Similarity: Contains 1 RING-type zinc fingerSimilarity: Contains 1 UIM (ubiquitin-interacting motif) repeat |
Function
for RNF166 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF166 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF166 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): RNF166 (NM_178841) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RNF166 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF166 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF166 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008270 | zinc ion binding |
IEA | -- |
RNF166 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for RNF166:
|
Pathways & Interactions
for RNF166 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNF166
STRING Interaction
Network Preview (showing 5 interactants - click image to see 17)
5/18 Interacting proteins for RNF166 (Q96A373 ENSP000003260954) via UniProtKB, MINT, STRING, and/or I2D (see all 18)About this table
|
Drugs & Compounds
for RNF166 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RNF166
Search CenterWatch for drugs/clinical trials and news about RNF166 / RN166
|
Transcripts
for RNF166 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RNF166 gene (3 alternative transcripts): NM_001171815.1 NM_001171816.1 NM_178841.3 Unigene Cluster for RNF166: Ring finger protein 166 Hs.513804 [show with all ESTs]Unigene Representative Sequence: NM_00117181611 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000312838(uc021tmo.1 uc002flk.3) ENST00000567408 ENST00000562544
ENST00000537718 ENST00000541206(uc021tmn.1) ENST00000565083 ENST00000568683
ENST00000567844 ENST00000564894 ENST00000562499 ENST00000569478
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF166 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF166 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): RNF166 (NM_178841) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RNF166 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF166 |
Additional cDNA sequence: AK026860.1 AK057106.1 AK057201.1 AK290920.1 BC013948.2 BC017226.1 13 DOTS entries: DT.107949 DT.95070030 DT.100782577 DT.91947399 DT.100654430 DT.91850458 DT.100782581 DT.91936004 DT.100665280 DT.100782578 DT.100782582 DT.75157380 DT.95070037 24/108 AceView cDNA sequences (see all 108): CR612154 CR620092 BE312288 CR598819 CR596749 BX280868 BI489894 BM978283 BE379210 BX374435 AK057106 BX375942 BF512191 AA280057 BM805412 BC013948 NM_178841 AL528714 AI282666 BG830046 AK057201 BU146800 BQ920690 AI570133
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for RNF166 (see all 8) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | · | 9c | · | 9d |
|---|
|
| SP1: | | | - | | - | | - | | - | | - | | | | | | | | - | | - | | | | | | | | | | - | | | | | | | | | | |
| SP2: | | | - | | - | | - | | - | | - | | | | | | | | - | | - | | | | | | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | | | | | - | | - | | | | | | | | | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | - | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for RNF166
|
Expression
for RNF166 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RNF166 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGTCTGCTG
About this image
See RNF166 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RNF166
SOURCE GeneReport for Unigene cluster: Hs.513804
SABiosciences Expression via Pathway-Focused PCR Array including RNF166:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNF166
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RNF166 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNF166 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNF166 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF166 |
Orthologs
for RNF166 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for RNF166 gene from 3/12 species (see all 12) About this table
ENSEMBL Gene Tree for RNF166 (if available)
TreeFam Gene Tree for RNF166 (if available) |
Paralogs
for RNF166 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RNF166 gene
- RNF1252 RNF1382 RNF1142
8 SIMAP similar genes for RNF166 using alignment to 4 protein entries: RN166_HUMAN (see all proteins):ZNF313 RNF114 BRCA1 TRIM5 TRIM39 RNF4
TRIM60 TRIM59
RNF166 for paralogs About GeneDecksing
|
Genomic Variants
for RNF166 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RNF166 (88762903 - 88772829 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for RNF166
4 CNVs: 4973 30012 30011 4974 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNF166 |
|
Disorders
/ Diseases
for RNF166 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for RNF166 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RNF166 gene integrated from 9 sources:
(articles sorted by number of sources associating them with RNF166) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Systematic analysis of dimeric E3-RING interactions re veals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)1 Woodsmith J....Sanderson C.M. (2012)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. (PubMed id 19549727)1 Markson G....Sanderson C.M. (2009)
- A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. (PubMed id 19690564)1 van Wijk S.J....Timmers H.T. (2009)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (2004)
|
External Searches for RNF166 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RNF166 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RNF166 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RNF166 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RNF166 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RNF166 gene:
Search GeneIP for patents involving RNF166
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RNF166 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RNF166 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RNF166 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNF166 | | | OriGene Protein Over-expression Lysate for RNF166 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for RNF166 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF166 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF166 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for RNF166 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RNF166 | | OriGene Custom Protein Services for RNF166 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RNF166 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNF166 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF166 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNF166 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNF166 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNF166 |
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| | | | Search Tocris compounds for RNF166 |
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 | | | RNF166 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF166 |
|  |  |  | | | | Search ThermoFisher Antibodies for RNF166 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF166 |
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