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Aliases for RNF166 Gene

Aliases for RNF166 Gene

  • Ring Finger Protein 166 2 3

External Ids for RNF166 Gene

Previous GeneCards Identifiers for RNF166 Gene

  • GC16M088508
  • GC16M087290
  • GC16M088762
  • GC16M074457

Summaries for RNF166 Gene

GeneCards Summary for RNF166 Gene

RNF166 (Ring Finger Protein 166) is a Protein Coding gene. An important paralog of this gene is RNF114.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF166 Gene

Genomics for RNF166 Gene

Regulatory Elements for RNF166 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RNF166 Gene

88,696,495 bp from pter
88,706,421 bp from pter
9,927 bases
Minus strand

Genomic View for RNF166 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNF166 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF166 Gene

Proteins for RNF166 Gene

  • Protein details for RNF166 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RING finger protein 166
    Protein Accession:
    Secondary Accessions:
    • B3KQ03
    • D3DX75
    • H3BTU8
    • Q96DM0

    Protein attributes for RNF166 Gene

    237 amino acids
    Molecular mass:
    26122 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RNF166 Gene


neXtProt entry for RNF166 Gene

Proteomics data for RNF166 Gene at MOPED

Post-translational modifications for RNF166 Gene

  • Ubiquitination at Lys129 and Lys167
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for RNF166 Gene

Domains for RNF166 Gene

Gene Families for RNF166 Gene

  • RNF :RING-type (C3HC4) zinc fingers

Suggested Antigen Peptide Sequences for RNF166 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q96A37
  • Contains 1 UIM (ubiquitin-interacting motif) domain.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF166: view

Function for RNF166 Gene

Gene Ontology (GO) - Molecular Function for RNF166 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with RNF166: view

Phenotypes for RNF166 Gene

GenomeRNAi human phenotypes for RNF166:
genes like me logo Genes that share phenotypes with RNF166: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNF166

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RNF166 Gene

Localization for RNF166 Gene

Subcellular locations from

Jensen Localization Image for RNF166 Gene COMPARTMENTS Subcellular localization image for RNF166 gene
Compartment Confidence
nucleus 3
cytosol 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RNF166 Gene

Pathways for RNF166 Gene

SuperPathways for RNF166 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for RNF166 Gene


No data available for Pathways by source for RNF166 Gene

Transcripts for RNF166 Gene

Unigene Clusters for RNF166 Gene

Ring finger protein 166:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNF166

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF166 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d
SP1: - - - - - - - -
SP2: - - - - - - - -
SP3: - - - -
SP4: - -
SP7: - -

Relevant External Links for RNF166 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNF166 Gene

mRNA expression in normal human tissues for RNF166 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNF166 Gene

This gene is overexpressed in Whole Blood (12.9).

Protein differential expression in normal tissues for RNF166 Gene

This gene is overexpressed in Neutrophil (46.1), Peripheral blood mononuclear cells (12.3), and Blymphocyte (6.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RNF166 Gene

SOURCE GeneReport for Unigene cluster for RNF166 Gene Hs.513804

genes like me logo Genes that share expressions with RNF166: view

Expression partners for RNF166 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for RNF166 Gene

Orthologs for RNF166 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNF166 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RNF166 35
  • 91.28 (n)
  • 94.51 (a)
RNF166 36
  • 95 (a)
(Canis familiaris)
Mammalia RNF166 35
  • 90.01 (n)
  • 94.94 (a)
RNF166 36
  • 95 (a)
(Mus musculus)
Mammalia Rnf166 35
  • 91.14 (n)
  • 98.73 (a)
Rnf166 16
Rnf166 36
  • 99 (a)
(Pan troglodytes)
Mammalia RNF166 35
  • 99.72 (n)
  • 100 (a)
RNF166 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Rnf166 35
  • 90.15 (n)
  • 98.73 (a)
(Monodelphis domestica)
Mammalia RNF166 36
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia RNF166 36
  • 86 (a)
(Gallus gallus)
Aves RNF166 35
  • 83.69 (n)
  • 86.7 (a)
RNF166 36
  • 91 (a)
(Anolis carolinensis)
Reptilia RNF166 36
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf166 35
  • 77.12 (n)
  • 89.41 (a)
(Danio rerio)
Actinopterygii LOC100334524 35
  • 75.81 (n)
  • 83.12 (a)
RNF166 (1 of 2) 36
  • 89 (a)
RNF166 (2 of 2) 36
  • 82 (a)
Species with no ortholog for RNF166:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF166 Gene

Gene Tree for RNF166 (if available)
Gene Tree for RNF166 (if available)

Paralogs for RNF166 Gene

Paralogs for RNF166 Gene

Selected SIMAP similar genes for RNF166 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with RNF166: view

Variants for RNF166 Gene

Sequence variations from dbSNP and Humsavar for RNF166 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs13556 -- 88,696,743(+) GCCCC(A/G)CCTCT utr-variant-3-prime
rs752843 -- 88,702,696(+) GAAAG(C/T)GGGAC intron-variant
rs753285 -- 88,703,626(-) GGGAA(A/G)CGGGC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs753286 -- 88,703,602(-) GCTGG(C/T)TCTCT intron-variant, utr-variant-5-prime
rs753287 -- 88,703,588(-) CACCA(A/G)GCTGG intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for RNF166 Gene

Variant ID Type Subtype PubMed ID
nsv907226 CNV Loss 21882294
nsv907255 CNV Loss 21882294
nsv833325 CNV Loss 17160897
nsv907268 CNV Loss 21882294
dgv2977n71 CNV Loss 21882294
dgv2978n71 CNV Loss 21882294
dgv2979n71 CNV Loss 21882294
nsv907278 CNV Loss 21882294
nsv907283 CNV Loss 21882294
dgv2981n71 CNV Loss 21882294
nsv471113 CNV Loss 18288195
nsv833327 CNV Loss 17160897
dgv2982n71 CNV Loss 21882294
dgv2983n71 CNV Loss 21882294
nsv907296 CNV Loss 21882294
dgv2984n71 CNV Loss 21882294
nsv471114 CNV Gain 18288195
dgv2985n71 CNV Loss 21882294
nsv907300 CNV Gain 21882294
nsv827833 CNV Gain 20364138
nsv907305 CNV Loss 21882294

Relevant External Links for RNF166 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF166 Gene

Disorders for RNF166 Gene

No disorders were found for RNF166 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for RNF166 Gene

Publications for RNF166 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. (PMID: 19549727) Markson G. … Sanderson C.M. (Genome Res. 2009) 3

Products for RNF166 Gene

Sources for RNF166 Gene

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