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Aliases for RNF165 Gene

Aliases for RNF165 Gene

  • Ring Finger Protein 165 2 3
  • RING Finger Protein 165 4 5
  • E3 Ubiquitin-Protein Ligase RNF165 3
  • EC 2.3.2.27 4
  • RNF111L2 3
  • ARKL2 3

External Ids for RNF165 Gene

Previous GeneCards Identifiers for RNF165 Gene

  • GC18U900221
  • GC18P042169
  • GC18P043914
  • GC18P040771

Summaries for RNF165 Gene

Entrez Gene Summary for RNF165 Gene

  • Encoded in regions involved in pericentric inversions in patients with bipolar affective disorder. [provided by RefSeq, Jul 2008]

GeneCards Summary for RNF165 Gene

RNF165 (Ring Finger Protein 165) is a Protein Coding gene. An important paralog of this gene is RNF111.

UniProtKB/Swiss-Prot for RNF165 Gene

  • E3 ubiquitin-protein ligase that acts as a regulator of motor axon elongation. Required for efficient motor axon extension in the dorsal forelimb by enhancing the transcriptional responses of the SMAD1/SMAD5/SMAD8 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD6, SMAD7, SKI and SNON isoform of SKIL.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF165 Gene

Genomics for RNF165 Gene

Regulatory Elements for RNF165 Gene

Enhancers for RNF165 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18G046418 0.9 Ensembl ENCODE 17.2 +92.7 92701 1.2 NR2F1 MAFG EBF1 EP300 RAD21 NR2F2 FOXA1 JUND ATF3 IKZF1 RNF165 LOC105372095 GC18P046450
GH18G046410 1.2 FANTOM5 Ensembl ENCODE 12.6 +85.3 85339 4.2 KLF1 RFX1 L3MBTL2 FEZF1 REST ZIC2 EP300 NR2F2 POLR2A GLIS1 RNF165 LOC105372095 GC18P046450
GH18G046414 0.8 Ensembl ENCODE 17.9 +88.0 88014 0.8 PKNOX1 L3MBTL2 IKZF1 MNT REST RAD21 RNF165 LOC105372095 GC18P046450
GH18G046259 1 Ensembl ENCODE 11.2 -64.1 -64120 6.6 PKNOX1 ZSCAN4 ZNF175 CEBPG CHD7 PRDM10 TRIM24 RFX1 CEBPB ZNF589 RNF165 ATP5A1 C18orf25 GC18P046277
GH18G046425 0.5 ENCODE 13.4 +98.4 98432 0.4 SIX4 ZFHX2 L3MBTL2 IKZF1 MGA RNF165 GC18P046450 LOC105372095
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RNF165 on UCSC Golden Path with GeneCards custom track

Genomic Location for RNF165 Gene

Chromosome:
18
Start:
46,326,809 bp from pter
End:
46,463,140 bp from pter
Size:
136,332 bases
Orientation:
Plus strand

Genomic View for RNF165 Gene

Genes around RNF165 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF165 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF165 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF165 Gene

Proteins for RNF165 Gene

  • Protein details for RNF165 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZSG1-RN165_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase RNF165
    Protein Accession:
    Q6ZSG1
    Secondary Accessions:
    • B3KVD1

    Protein attributes for RNF165 Gene

    Size:
    346 amino acids
    Molecular mass:
    39526 Da
    Quaternary structure:
    • Monomer; binding to the ubiquitin-conjugating enzyme E2 does not trigger homodimerization (PubMed:26656854).

    Three dimensional structures from OCA and Proteopedia for RNF165 Gene

    Alternative splice isoforms for RNF165 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNF165 Gene

Post-translational modifications for RNF165 Gene

No data available for DME Specific Peptides for RNF165 Gene

Domains & Families for RNF165 Gene

Gene Families for RNF165 Gene

Protein Domains for RNF165 Gene

Suggested Antigen Peptide Sequences for RNF165 Gene

Graphical View of Domain Structure for InterPro Entry

Q6ZSG1

UniProtKB/Swiss-Prot:

RN165_HUMAN :
  • The RING-type zinc finger mediates the E3 ubiquitin-protein ligase activity and binds directly to free ubiquitin (PubMed:26656854). Non-covalent ubiquitin-binding stabilizes the ubiquitin-conjugating enzyme E2 (donor ubiquitin) in the closed conformation and stimulates ubiquitin transfer (PubMed:26656854).
  • Belongs to the Arkadia family.
Domain:
  • The RING-type zinc finger mediates the E3 ubiquitin-protein ligase activity and binds directly to free ubiquitin (PubMed:26656854). Non-covalent ubiquitin-binding stabilizes the ubiquitin-conjugating enzyme E2 (donor ubiquitin) in the closed conformation and stimulates ubiquitin transfer (PubMed:26656854).
Family:
  • Belongs to the Arkadia family.
genes like me logo Genes that share domains with RNF165: view

Function for RNF165 Gene

Molecular function for RNF165 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot EnzymeRegulation:
Binds free ubiquitin non-covalently via its RING-type zinc finger. Ubiquitin-binding leads to enhance the E3 ubiquitin-protein ligase activity by stabilizing the ubiquitin-conjugating enzyme E2 (donor ubiquitin) in the closed conformation and activating ubiquitin transfer (PubMed:26656854).
UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase that acts as a regulator of motor axon elongation. Required for efficient motor axon extension in the dorsal forelimb by enhancing the transcriptional responses of the SMAD1/SMAD5/SMAD8 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD6, SMAD7, SKI and SNON isoform of SKIL.

Enzyme Numbers (IUBMB) for RNF165 Gene

Gene Ontology (GO) - Molecular Function for RNF165 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0016740 transferase activity IEA --
GO:0016874 ligase activity IEA --
GO:0046872 metal ion binding IEA --
GO:0061630 ubiquitin protein ligase activity IBA --
genes like me logo Genes that share ontologies with RNF165: view
genes like me logo Genes that share phenotypes with RNF165: view

Animal Model Products

CRISPR Products

miRNA for RNF165 Gene

miRTarBase miRNAs that target RNF165

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNF165 Gene

Localization for RNF165 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF165 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNF165 gene
Compartment Confidence
nucleus 4
plasma membrane 3
mitochondrion 3
cytosol 3
endoplasmic reticulum 2
extracellular 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for RNF165 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA --
GO:0005737 cytoplasm IBA --
GO:0043234 protein complex IEA --
genes like me logo Genes that share ontologies with RNF165: view

Pathways & Interactions for RNF165 Gene

SuperPathways for RNF165 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RNF165 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IBA --
GO:0007409 axonogenesis IEA --
GO:0008045 motor neuron axon guidance IBA --
GO:0010259 multicellular organism aging IEA --
GO:0030163 protein catabolic process IEA --
genes like me logo Genes that share ontologies with RNF165: view

No data available for Pathways by source and SIGNOR curated interactions for RNF165 Gene

Transcripts for RNF165 Gene

mRNA/cDNA for RNF165 Gene

(4) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RNF165 Gene

Ring finger protein 165:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNF165 Gene

No ASD Table

Relevant External Links for RNF165 Gene

GeneLoc Exon Structure for
RNF165
ECgene alternative splicing isoforms for
RNF165

Expression for RNF165 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNF165 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNF165 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x5.9) and Brain - Cerebellum (x5.1).

Protein differential expression in normal tissues from HIPED for RNF165 Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RNF165 Gene



Protein tissue co-expression partners for RNF165 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RNF165 Gene:

RNF165

SOURCE GeneReport for Unigene cluster for RNF165 Gene:

Hs.501114

Evidence on tissue expression from TISSUES for RNF165 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with RNF165: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNF165 Gene

Orthologs for RNF165 Gene

This gene was present in the common ancestor of animals.

Orthologs for RNF165 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNF165 34 35
  • 99.81 (n)
cow
(Bos Taurus)
Mammalia LOC537072 34
  • 95.18 (n)
RNF165 35
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNF165 34 35
  • 94.61 (n)
rat
(Rattus norvegicus)
Mammalia Rnf165 34
  • 94.22 (n)
mouse
(Mus musculus)
Mammalia Rnf165 34 16 35
  • 94.03 (n)
oppossum
(Monodelphis domestica)
Mammalia RNF165 35
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 91 (a)
OneToMany
-- 35
  • 75 (a)
OneToMany
chicken
(Gallus gallus)
Aves RNF165 34 35
  • 82.46 (n)
lizard
(Anolis carolinensis)
Reptilia RNF165 35
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf165 34
  • 79.51 (n)
zebrafish
(Danio rerio)
Actinopterygii rnf165b 34 35
  • 69.89 (n)
rnf165a 35
  • 63 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6923 35
  • 5 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea toe-4 35
  • 12 (a)
OneToMany
Species where no ortholog for RNF165 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RNF165 Gene

ENSEMBL:
Gene Tree for RNF165 (if available)
TreeFam:
Gene Tree for RNF165 (if available)

Paralogs for RNF165 Gene

Paralogs for RNF165 Gene

(1) SIMAP similar genes for RNF165 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with RNF165: view

Variants for RNF165 Gene

Sequence variations from dbSNP and Humsavar for RNF165 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1000004578 -- 46,377,235(+) CTTTA(A/C)AGAAA intron-variant
rs1000018115 -- 46,437,917(+) ACCTC(C/T)GATTG intron-variant
rs1000018122 -- 46,347,170(+) GGGAG(G/T)GATCG intron-variant
rs1000039152 -- 46,389,646(+) GACTT(C/G)GGCCC intron-variant, nc-transcript-variant
rs1000062341 -- 46,421,013(+) GCAGA(C/T)CCCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNF165 Gene

Variant ID Type Subtype PubMed ID
dgv596e199 CNV deletion 23128226
esv22561 CNV loss 19812545
esv24686 CNV loss 19812545
esv2677564 CNV deletion 23128226
esv3326438 CNV duplication 20981092
esv3419380 CNV duplication 20981092
esv3642432 CNV loss 21293372
esv3642433 CNV loss 21293372
nsv1072797 CNV deletion 25765185
nsv1144832 CNV deletion 24896259
nsv2279 CNV insertion 18451855
nsv471938 CNV novel sequence insertion 20440878
nsv576811 CNV loss 21841781
nsv576812 CNV loss 21841781
nsv828224 CNV gain 20364138

Variation tolerance for RNF165 Gene

Residual Variation Intolerance Score: 27.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.63; 31.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNF165 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNF165

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF165 Gene

Disorders for RNF165 Gene

Relevant External Links for RNF165

Genetic Association Database (GAD)
RNF165
Human Genome Epidemiology (HuGE) Navigator
RNF165
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RNF165

No disorders were found for RNF165 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF165 Gene

Publications for RNF165 Gene

  1. Secondary ubiquitin-RING docking enhances Arkadia and Ark2C E3 ligase activity. (PMID: 26656854) Wright J.D. … Day C.L. (Nat. Struct. Mol. Biol. 2016) 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. (PMID: 19690564) van Wijk S.J. … Timmers H.T. (Mol. Syst. Biol. 2009) 3 64
  5. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PMID: 17903300) Fox C.S. … Atwood L.D. (BMC Med. Genet. 2007) 46 64

Products for RNF165 Gene

Sources for RNF165 Gene

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