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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RNF165 Gene

protein-coding   GIFtS: 44
GCID: GC18P043914

Ring Finger Protein 165

  Search for RNF165
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ring Finger Protein 1651 2
ARKL22

External Ids:    HGNC: 316961   Entrez Gene: 4944702   Ensembl: ENSG000001416227   UniProtKB: Q6ZSG13   

Export aliases for RNF165 gene to outside databases

Previous GC identifers: GC18U900221 GC18P042169 GC18P040771


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RNF165 Gene:
Encoded in regions involved in pericentric inversions in patients with bipolar affective disorder. (provided by
RefSeq, Jul 2008)

GeneCards Summary for RNF165 Gene: 
RNF165 (ring finger protein 165) is a protein-coding gene. GO annotations related to this gene include zinc ion binding. An important paralog of this gene is RNF111.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NT_010966.14  NC_018929.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RNF165 gene promoter:
         Sox5   NF-1   NCX/Ncx   HTF   NF-AT   GATA-2   SRY   NF-AT3   Chx10   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNF165 promoter sequence
   Search SABiosciences Chromatin IP Primers for RNF165

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF165


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21.1   Ensembl cytogenetic band:  18q21.1   HGNC cytogenetic band: 18q21.1

RNF165 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF165 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P043914:  view genomic region     (about GC identifiers)

Start:
43,906,772 bp from pter      End:
44,043,103 bp from pter
Size:
136,332 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RN165_HUMAN, Q6ZSG1 (See protein sequence)
Recommended Name: RING finger protein 165  
Size: 346 amino acids; 39526 Da
Secondary accessions: B3KVD1
Alternative splicing: 2 isoforms:  Q6ZSG1-1   Q6ZSG1-2   

Explore the universe of human proteins at neXtProt for RNF165: NX_Q6ZSG1

Explore proteomics data for RNF165 at MOPED 

RNF165 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

RNF165 Protein Expression

REFSEQ proteins (2 alternative transcripts): 
NP_001243687.1  NP_689683.2  

ENSEMBL proteins: 
 ENSP00000467730   ENSP00000466208   ENSP00000466809   ENSP00000467609   ENSP00000468365  
 ENSP00000269439   ENSP00000444285  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
RNF: RING-type (C3HC4) zinc fingers

2 InterPro protein domains:
 IPR001841 Znf_RING
 IPR013083 Znf_RING/FYVE/PHD

Graphical View of Domain Structure for InterPro Entry Q6ZSG1

ProtoNet protein and cluster: Q6ZSG1

1 Blocks protein domain: IPB001841 Zn-finger

UniProtKB/Swiss-Prot: RN165_HUMAN, Q6ZSG1
Similarity: Contains 1 RING-type zinc finger


RNF165 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

     Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
GO:0008270zinc ion binding IEA--
GO:0046872metal ion binding ----
     
RNF165 for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for RNF165:
 Increased gamma-H2AX phosphory 

Animal Models:
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNF165

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

5/9 Interacting proteins for RNF165 (Q6ZSG13 ENSP000002694394) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
InteractantInteraction Details
GeneCardExternal ID(s)
UBE2D2P628373, ENSP000003817174I2D: score=2 STRING: ENSP00000381717
UBE2D3P610773, ENSP000003497224I2D: score=2 STRING: ENSP00000349722
UBE2NP610883, ENSP000003161764I2D: score=2 STRING: ENSP00000316176
UBE2WQ96B023, ENSP000003974534I2D: score=2 STRING: ENSP00000397453
UBE2D1P516683, ENSP000003630194I2D: score=2 STRING: ENSP00000363019
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RNF165 (RN165)

Search CenterWatch for drugs/clinical trials and news about RNF165 / RN165

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RNF165 gene (2 alternative transcripts): 
NM_001256758.1  NM_152470.2  

Unigene Cluster for RNF165:

Ring finger protein 165
Hs.501114  [show with all ESTs]
Unigene Representative Sequence: NM_152470
8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000593230 ENST00000587853 ENST00000590330 ENST00000588679 ENST00000586604
ENST00000269439(uc002lby.1 uc002lcb.1 uc010dnn.1) ENST00000592777
ENST00000543885(uc002lca.1)
miRNA
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hsa-miR-1321 hsa-miR-631 hsa-miR-1914* hsa-miR-3921 hsa-miR-3162-5p hsa-miR-877* hsa-miR-298 hsa-miR-3649
SwitchGear 3'UTR luciferase reporter plasmids (see all 2): RNF165 3' UTR sequence
Inhib. RNA
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Additional mRNA sequence: 

AK055997.1 AK074561.1 AK096648.1 AK122819.1 AK123883.1 AK127467.1 BC012190.1 NR_046357.1 

5 DOTS entries:

DT.97803328  DT.80102033  DT.91724792  DT.100017417  DT.100017416 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RNF165 expression in normal human tissues (normalized intensities)      RNF165 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: ACGACATTGT
RNF165 Expression
About this image


RNF165 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/11 selected tissues (see all 11) fully expand
 
 Brain (Nervous System)    fully expand to see all 4 entries
         Endothelial Cells Blood Brain Barrier
         prefrontal cortex   
 
 Bone (Muscoskeletal System)    fully expand to see all 2 entries
         Mesenchymal Condensate Cells Zeugopod
         Zeugopod Epiphyseal End
 
 Blood Brain Barrier (Nervous System)    fully expand to see all 2 entries
         Endothelial Cells Blood Brain Barrier
 
 Endothelium (Cardiovascular System)    fully expand to see all 2 entries
         Endothelial Cells Blood Brain Barrier
 
 Colon (Gastrointestinal Tract)
         distal colon   

See RNF165 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RNF165

SOURCE GeneReport for Unigene cluster: Hs.501114
    SABiosciences Custom PCR Arrays for RNF165
Primer
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for RNF165 gene from 6/12 species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Rnf1651 , 5 ring finger protein 1651, 5 94.03(n)1
98.84(a)1
  18 (52.28 cM)5
2257431  NM_001164504.11  NP_001157976.11 
 774561105 
chicken
(Gallus gallus)
Aves RNF1651 ring finger protein 165 82.46(n)
88.66(a)
  416382  XM_414696.3  XP_414696.3 
lizard
(Anolis carolinensis)
Reptilia RNF1656
Uncharacterized protein
87(a)
1 ↔ 1
1(34827093-34963825)
zebrafish
(Danio rerio)
Actinopterygii rnf165b1 ring finger protein 165b 69.79(n)
72.73(a)
  572413  XM_696125.4  XP_701217.3 
fruit fly
(Drosophila melanogaster)
Insecta CG69236
--
6(a)
1 → many
3R(7570205-7575751)
worm
(Caenorhabditis elegans)
Secernentea toe-46
Protein TOE-4
11(a)
1 → many
I(12738087-12741149)


ENSEMBL Gene Tree for RNF165 (if available)
TreeFam Gene Tree for RNF165 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for RNF165 gene
RNF1112  
1 SIMAP similar gene for RNF165 using alignment to 5 protein entries:     RN165_HUMAN (see all proteins):
RNF111

RNF165 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/2783 SNPs in RNF165 are shown (see all 2783)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 18 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs751881921,2
F--43912233(+) TGGCCA/GTCTTC 3 -- us2k10--------
rs1402904951,2
--43912258(+) TGGGGG/TCAGCC 3 -- us2k10--------
rs1924388461,2
--43912286(+) AGAGAA/GCTCAG 3 -- us2k10--------
rs1451991111,2
--43912343(+) GGTTCA/TGCCCT 3 -- us2k10--------
rs1378903311,2
C--43912349(+) GCCCTA/TGCCAC 3 -- us2k10--------
rs1820068131,2
--43912375(+) TGTCTA/GGGTAA 3 -- us2k10--------
rs1407009591,2
--43912525(+) GCTGGA/GTGCCC 3 -- us2k10--------
rs99521131,2
C,F--43912764(+) CCAGCT/CCCACA 3 -- us2k111Minor allele frequency- C:0.28NA WA EA 508
rs1172863451,2
C,F--43912859(+) AATGTC/TCTCTG 3 -- us2k11Minor allele frequency- T:0.01NA 120
rs769007481,2
F--43912861(+) TGTCCT/CCTGTC 3 -- us2k11Minor allele frequency- C:0.02EA 120

HapMap Linkage Disequilibrium report for RNF165 (43906772 - 44043103 bp)

Structural Variations
     Database of Genomic Variants (DGV) 6 variations for RNF165:    About this table     
Variant IDTypeSubtypePubMed ID
dgv596e199CNV Deletion23128226
esv2677564CNV Deletion23128226
nsv2279CNV Insertion18451855
esv24686CNV Loss19812545
esv22561CNV Loss19812545
nsv828224CNV Gain20364138

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RNF165 for disorders           About MalaCards

RNF165 for disorders           About GeneDecksing

Genetic Association Database (GAD): RNF165
Human Genome Epidemiology (HuGE) Navigator: RNF165 (1 document)

Export disorders for RNF165 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for RNF165 gene integrated from 9 sources:
(articles sorted by number of sources associating them with RNF165)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  3. A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. (PubMed id 19690564)1 van Wijk S.J....Timmers H.T. (2009)
  4. Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)2 Chen R.... Zou H. (2009)
  5. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PubMed id 17903300)4 Fox C.S....Atwood L.D. (2007)
  6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
  7. DNA sequence and analysis of human chromosome 18. (PubMed id 16177791)2 Nusbaum C.... Lander E.S. (2005)
  8. Candidate psychiatric illness genes identified in patients with pericentric inversions of chromosome 18. (PubMed id 15722956)1 Pickard B.S.... Muir W.J. (2005)
  9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  10. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 494470 HGNC: 31696 Ensembl:ENSG00000141622 euGenes: HUgn494470 ECgene: RNF165
H-InvDB: RNF165

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for RNF165 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for RNF165 gene:
Search GeneIP for patents involving RNF165

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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