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Aliases for RNF165 Gene

Aliases for RNF165 Gene

  • Ring Finger Protein 165 2 3 5
  • RNF111L2 3
  • ARKL2 3

External Ids for RNF165 Gene

Previous GeneCards Identifiers for RNF165 Gene

  • GC18U900221
  • GC18P042169
  • GC18P043914
  • GC18P040771

Summaries for RNF165 Gene

Entrez Gene Summary for RNF165 Gene

  • Encoded in regions involved in pericentric inversions in patients with bipolar affective disorder. [provided by RefSeq, Jul 2008]

GeneCards Summary for RNF165 Gene

RNF165 (Ring Finger Protein 165) is a Protein Coding gene. An important paralog of this gene is RNF111.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF165 Gene

Genomics for RNF165 Gene

Regulatory Elements for RNF165 Gene

Enhancers for RNF165 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RNF165 on UCSC Golden Path with GeneCards custom track

Genomic Location for RNF165 Gene

46,326,809 bp from pter
46,463,140 bp from pter
136,332 bases
Plus strand

Genomic View for RNF165 Gene

Genes around RNF165 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF165 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF165 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF165 Gene

Proteins for RNF165 Gene

  • Protein details for RNF165 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RING finger protein 165
    Protein Accession:
    Secondary Accessions:
    • B3KVD1

    Protein attributes for RNF165 Gene

    346 amino acids
    Molecular mass:
    39526 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RNF165 Gene

    Alternative splice isoforms for RNF165 Gene


neXtProt entry for RNF165 Gene

Proteomics data for RNF165 Gene at MOPED

Post-translational modifications for RNF165 Gene

No data available for DME Specific Peptides for RNF165 Gene

Domains & Families for RNF165 Gene

Gene Families for RNF165 Gene

Protein Domains for RNF165 Gene


Suggested Antigen Peptide Sequences for RNF165 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 RING-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF165: view

Function for RNF165 Gene

Gene Ontology (GO) - Molecular Function for RNF165 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with RNF165: view
genes like me logo Genes that share phenotypes with RNF165: view

Animal Model Products

miRNA for RNF165 Gene

miRTarBase miRNAs that target RNF165

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNF165 Gene

Localization for RNF165 Gene

Subcellular locations from

Jensen Localization Image for RNF165 Gene COMPARTMENTS Subcellular localization image for RNF165 gene
Compartment Confidence
nucleus 4
cytosol 3
mitochondrion 3
plasma membrane 3
endoplasmic reticulum 2
extracellular 1
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RNF165 Gene

Pathways & Interactions for RNF165 Gene

SuperPathways for RNF165 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RNF165 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007409 axonogenesis IEA --
GO:0008045 motor neuron axon guidance IBA --
GO:0035136 forelimb morphogenesis IEA --
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA --
genes like me logo Genes that share ontologies with RNF165: view

No data available for Pathways by source and SIGNOR curated interactions for RNF165 Gene

Drugs & Compounds for RNF165 Gene

No Compound Related Data Available

Transcripts for RNF165 Gene

mRNA/cDNA for RNF165 Gene

(4) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RNF165 Gene

Ring finger protein 165:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNF165 Gene

No ASD Table

Relevant External Links for RNF165 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNF165 Gene

mRNA expression in normal human tissues for RNF165 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNF165 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x5.9) and Brain - Cerebellum (x5.1).

Protein differential expression in normal tissues from HIPED for RNF165 Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RNF165 Gene

SOURCE GeneReport for Unigene cluster for RNF165 Gene Hs.501114

genes like me logo Genes that share expression patterns with RNF165: view

Protein tissue co-expression partners for RNF165 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for RNF165 Gene

Orthologs for RNF165 Gene

This gene was present in the common ancestor of animals.

Orthologs for RNF165 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC537072 35
  • 95.18 (n)
  • 98.15 (a)
RNF165 36
  • 93 (a)
(Canis familiaris)
Mammalia RNF165 35
  • 94.61 (n)
  • 98.27 (a)
RNF165 36
  • 98 (a)
(Mus musculus)
Mammalia Rnf165 35
  • 94.03 (n)
  • 98.84 (a)
Rnf165 16
Rnf165 36
  • 99 (a)
(Pan troglodytes)
Mammalia RNF165 35
  • 99.81 (n)
  • 100 (a)
RNF165 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Rnf165 35
  • 94.22 (n)
  • 98.84 (a)
(Monodelphis domestica)
Mammalia RNF165 36
  • 94 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 75 (a)
-- 36
  • 91 (a)
(Gallus gallus)
Aves RNF165 35
  • 82.46 (n)
  • 88.66 (a)
RNF165 36
  • 87 (a)
(Anolis carolinensis)
Reptilia RNF165 36
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf165 35
  • 79.51 (n)
  • 86.24 (a)
(Danio rerio)
Actinopterygii rnf165b 35
  • 69.89 (n)
  • 72.73 (a)
rnf165a 36
  • 63 (a)
rnf165b 36
  • 71 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6923 36
  • 5 (a)
(Caenorhabditis elegans)
Secernentea toe-4 36
  • 12 (a)
Species with no ortholog for RNF165:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RNF165 Gene

Gene Tree for RNF165 (if available)
Gene Tree for RNF165 (if available)

Paralogs for RNF165 Gene

Paralogs for RNF165 Gene

(1) SIMAP similar genes for RNF165 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with RNF165: view

Variants for RNF165 Gene

Sequence variations from dbSNP and Humsavar for RNF165 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1580009 -- 46,449,691(-) ccaag(A/C)gaatg intron-variant
rs1668049 -- 46,445,934(-) ggatt(C/T)ttcaa intron-variant
rs7231421 -- 46,368,580(+) TGAGG(C/T)AATTC intron-variant
rs7231582 -- 46,368,645(+) AGGCA(C/T)CATGA intron-variant
rs7232401 -- 46,347,599(+) TCCTC(A/C)TCTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNF165 Gene

Variant ID Type Subtype PubMed ID
nsv828224 CNV Gain 20364138
esv22561 CNV Loss 19812545
dgv596e199 CNV Deletion 23128226
esv24686 CNV Loss 19812545
esv2677564 CNV Deletion 23128226
nsv2279 CNV Insertion 18451855

Variation tolerance for RNF165 Gene

Residual Variation Intolerance Score: 27.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.63; 31.36% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RNF165 Gene

Disorders for RNF165 Gene

Relevant External Links for RNF165

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RNF165 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF165 Gene

Publications for RNF165 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. Secondary ubiquitin-RING docking enhances Arkadia and Ark2C E3 ligase activity. (PMID: 26656854) Wright J.D. … Day C.L. (Nat. Struct. Mol. Biol. 2016) 3
  3. A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. (PMID: 19690564) van Wijk S.J. … Timmers H.T. (Mol. Syst. Biol. 2009) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Candidate psychiatric illness genes identified in patients with pericentric inversions of chromosome 18. (PMID: 15722956) Pickard B.S. … Muir W.J. (Psychiatr. Genet. 2005) 3

Products for RNF165 Gene

Sources for RNF165 Gene