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Aliases for RNF157 Gene

Aliases for RNF157 Gene

  • Ring Finger Protein 157 2 3
  • KIAA1917 4

External Ids for RNF157 Gene

Previous GeneCards Identifiers for RNF157 Gene

  • GC17M074738
  • GC17M071651
  • GC17M074138
  • GC17M069567

Summaries for RNF157 Gene

GeneCards Summary for RNF157 Gene

RNF157 (Ring Finger Protein 157) is a Protein Coding gene. An important paralog of this gene is MGRN1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF157 Gene

Genomics for RNF157 Gene

Regulatory Elements for RNF157 Gene

Genomic Location for RNF157 Gene

Start:
76,142,453 bp from pter
End:
76,240,373 bp from pter
Size:
97,921 bases
Orientation:
Minus strand

Genomic View for RNF157 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNF157 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF157 Gene

Proteins for RNF157 Gene

  • Protein details for RNF157 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PX1-RN157_HUMAN
    Recommended name:
    RING finger protein 157
    Protein Accession:
    Q96PX1
    Secondary Accessions:
    • Q8NB72
    • Q96N56

    Protein attributes for RNF157 Gene

    Size:
    679 amino acids
    Molecular mass:
    73579 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB67810.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB71053.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC03669.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RNF157 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNF157 Gene

Proteomics data for RNF157 Gene at MOPED

Post-translational modifications for RNF157 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RNF157 Gene

No data available for DME Specific Peptides for RNF157 Gene

Domains for RNF157 Gene

Gene Families for RNF157 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for RNF157 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for RNF157 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96PX1

UniProtKB/Swiss-Prot:

RN157_HUMAN :
  • Q96PX1
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF157: view

Function for RNF157 Gene

Gene Ontology (GO) - Molecular Function for RNF157 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with RNF157: view

Phenotypes for RNF157 Gene

GenomeRNAi human phenotypes for RNF157:
genes like me logo Genes that share phenotypes with RNF157: view

Animal Model Products

CRISPR Products

miRNA for RNF157 Gene

miRTarBase miRNAs that target RNF157

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNF157

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RNF157 Gene

Localization for RNF157 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNF157 Gene COMPARTMENTS Subcellular localization image for RNF157 gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RNF157 Gene

Pathways for RNF157 Gene

SuperPathways for RNF157 Gene

No Data Available

Interacting Proteins for RNF157 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000269391%0d%0a9606.ENSP00000338348%0d%0a
Selected Interacting proteins: ENSP00000269391 Q96PX1-RN157_HUMAN for RNF157 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for RNF157 Gene

None

No data available for Pathways by source for RNF157 Gene

Transcripts for RNF157 Gene

Unigene Clusters for RNF157 Gene

Ring finger protein 157:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNF157

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for RNF157
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF157 Gene

No ASD Table

Relevant External Links for RNF157 Gene

GeneLoc Exon Structure for
RNF157
ECgene alternative splicing isoforms for
RNF157

Expression for RNF157 Gene

mRNA expression in normal human tissues for RNF157 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNF157 Gene

This gene is overexpressed in Brain - Cortex (5.3), Brain - Frontal Cortex (BA9) (4.8), Muscle - Skeletal (4.4), and Brain - Anterior cingulate cortex (BA24) (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RNF157 Gene

SOURCE GeneReport for Unigene cluster for RNF157 Gene Hs.500643

genes like me logo Genes that share expressions with RNF157: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for RNF157 Gene

Orthologs for RNF157 Gene

This gene was present in the common ancestor of animals.

Orthologs for RNF157 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNF157 35
  • 98.55 (n)
  • 98.39 (a)
RNF157 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RNF157 35
  • 87.24 (n)
  • 92.34 (a)
RNF157 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNF157 35
  • 89.21 (n)
  • 93.07 (a)
RNF157 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnf157 35
  • 87.86 (n)
  • 93.07 (a)
Rnf157 16
Rnf157 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RNF157 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RNF157 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnf157 35
  • 85.03 (n)
  • 89.17 (a)
chicken
(Gallus gallus)
Aves RNF157 35
  • 78.72 (n)
  • 84.58 (a)
RNF157 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RNF157 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf157 35
  • 72.4 (n)
  • 79.87 (a)
zebrafish
(Danio rerio)
Actinopterygii RNF157 36
  • 70 (a)
OneToOne
si:dkey-49c17.3 35
  • 70.97 (n)
  • 74.16 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9941 36
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C11H1.3 36
  • 30 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
OneToMany
Species with no ortholog for RNF157:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RNF157 Gene

ENSEMBL:
Gene Tree for RNF157 (if available)
TreeFam:
Gene Tree for RNF157 (if available)

Paralogs for RNF157 Gene

Paralogs for RNF157 Gene

Selected SIMAP similar genes for RNF157 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with RNF157: view

Variants for RNF157 Gene

Sequence variations from dbSNP and Humsavar for RNF157 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs881502 -- 76,156,285(-) TCACC(C/T)TGTCG synonymous-codon, reference, downstream-variant-500B
rs894544 -- 76,155,375(+) AAACC(C/T)AAACC intron-variant
rs920713 -- 76,178,804(+) TTAGG(C/G)AGCAG intron-variant
rs1108127 -- 76,204,757(+) ATGCA(C/T)CTTAT intron-variant
rs1376356 -- 76,166,425(-) GCACA(C/T)TGCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNF157 Gene

Variant ID Type Subtype PubMed ID
nsv908824 CNV Loss 21882294
nsv833546 CNV Loss 17160897
dgv3270n71 CNV Loss 21882294
nsv2144 CNV Insertion 18451855
nsv833547 CNV Loss 17160897
dgv3271n71 CNV Loss 21882294
nsv828104 CNV Loss 20364138
esv26992 CNV Loss 19812545

Relevant External Links for RNF157 Gene

HapMap Linkage Disequilibrium report
RNF157

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF157 Gene

Disorders for RNF157 Gene

Relevant External Links for RNF157

Genetic Association Database (GAD)
RNF157
Human Genome Epidemiology (HuGE) Navigator
RNF157
genes like me logo Genes that share disorders with RNF157: view

No data available for UniProtKB/Swiss-Prot for RNF157 Gene

Publications for RNF157 Gene

  1. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PMID: 11572484) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  5. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 48

Products for RNF157 Gene

Sources for RNF157 Gene

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