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Aliases for RNF157 Gene

Aliases for RNF157 Gene

  • Ring Finger Protein 157 2 3 5
  • KIAA1917 4

External Ids for RNF157 Gene

Previous GeneCards Identifiers for RNF157 Gene

  • GC17M074738
  • GC17M071651
  • GC17M074138
  • GC17M069567

Summaries for RNF157 Gene

GeneCards Summary for RNF157 Gene

RNF157 (Ring Finger Protein 157) is a Protein Coding gene. An important paralog of this gene is MGRN1.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF157 Gene

Genomics for RNF157 Gene

Regulatory Elements for RNF157 Gene

Enhancers for RNF157 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G076258 2 FANTOM5 Ensembl ENCODE dbSUPER 29.6 -27.6 -27603 19.6 AGO1 DMAP1 YY1 ZNF143 SP3 NFYC TBX21 MEF2D ZNF610 ZNF585B RNF157 QRICH2 ENSG00000267342 UBALD2 ENSG00000267546 PRPSAP1 CASKIN2 FOXJ1 EXOC7 PRCD
GH17G076207 1.2 ENCODE 24.1 +32.5 32501 1.6 CREB3L1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 SP3 TBX21 RNF157 UNK ENSG00000266980 MFSD11 METTL23 FOXJ1 EXOC7 MRPL38 ENSG00000267342 MGAT5B
GH17G076238 1.3 ENCODE dbSUPER 19.2 -0.3 -302 3.6 ATF1 CREB3L1 ARNT SIN3A ZNF2 ZNF48 GLIS2 GATA2 FOS KLF13 RNF157 UBALD2 FOXJ1 QRICH2 AANAT UBE2O LOC105371896
GH17G076240 1.2 ENCODE dbSUPER 19.4 +2.2 2189 0.3 HNRNPUL1 FOXA2 MLX ARID4B YY1 SLC30A9 SP5 MXD4 PPARG KAT8 RNF157 ATF4P3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RNF157 on UCSC Golden Path with GeneCards custom track

Promoters for RNF157 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000098531 -127 1001 ATF1 CREB3L1 SIN3A ZNF2 ZNF48 GLIS2 FOS KLF13 SP3 NFYC

Genomic Location for RNF157 Gene

76,142,453 bp from pter
76,240,373 bp from pter
97,921 bases
Minus strand

Genomic View for RNF157 Gene

Genes around RNF157 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF157 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF157 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF157 Gene

Proteins for RNF157 Gene

  • Protein details for RNF157 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RING finger protein 157
    Protein Accession:
    Secondary Accessions:
    • Q8NB72
    • Q96N56

    Protein attributes for RNF157 Gene

    679 amino acids
    Molecular mass:
    73579 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB67810.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB71053.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC03669.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RNF157 Gene


neXtProt entry for RNF157 Gene

Post-translational modifications for RNF157 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RNF157 Gene

Domains & Families for RNF157 Gene

Gene Families for RNF157 Gene

Protein Domains for RNF157 Gene


Suggested Antigen Peptide Sequences for RNF157 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RNF157: view

No data available for UniProtKB/Swiss-Prot for RNF157 Gene

Function for RNF157 Gene

Gene Ontology (GO) - Molecular Function for RNF157 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RNF157: view
genes like me logo Genes that share phenotypes with RNF157: view

Animal Models for RNF157 Gene

MGI Knock Outs for RNF157:

Animal Model Products

CRISPR Products

miRNA for RNF157 Gene

miRTarBase miRNAs that target RNF157

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RNF157 Gene

Localization for RNF157 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNF157 gene
Compartment Confidence
nucleus 3
cytosol 2
golgi apparatus 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RNF157 Gene

Pathways & Interactions for RNF157 Gene

SuperPathways for RNF157 Gene

No Data Available

Interacting Proteins for RNF157 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: Q96PX1-RN157_HUMAN ENSP00000269391 for RNF157 Gene via IID STRING

Gene Ontology (GO) - Biological Process for RNF157 Gene


No data available for Pathways by source and SIGNOR curated interactions for RNF157 Gene

Drugs & Compounds for RNF157 Gene

No Compound Related Data Available

Transcripts for RNF157 Gene

Unigene Clusters for RNF157 Gene

Ring finger protein 157:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF157 Gene

No ASD Table

Relevant External Links for RNF157 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNF157 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNF157 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNF157 Gene

This gene is overexpressed in Brain - Cortex (x5.3), Brain - Frontal Cortex (BA9) (x4.8), Muscle - Skeletal (x4.4), and Brain - Anterior cingulate cortex (BA24) (x4.2).

Protein differential expression in normal tissues from HIPED for RNF157 Gene

This gene is overexpressed in Frontal cortex (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RNF157 Gene

Protein tissue co-expression partners for RNF157 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RNF157 Gene:


SOURCE GeneReport for Unigene cluster for RNF157 Gene:


Evidence on tissue expression from TISSUES for RNF157 Gene

  • Nervous system(4.7)
  • Eye(2.2)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with RNF157: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNF157 Gene

Orthologs for RNF157 Gene

This gene was present in the common ancestor of animals.

Orthologs for RNF157 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RNF157 34 35
  • 98.55 (n)
(Canis familiaris)
Mammalia RNF157 34 35
  • 89.21 (n)
(Monodelphis domestica)
Mammalia RNF157 35
  • 88 (a)
(Mus musculus)
Mammalia Rnf157 34 16 35
  • 87.86 (n)
(Bos Taurus)
Mammalia RNF157 34 35
  • 87.24 (n)
(Rattus norvegicus)
Mammalia Rnf157 34
  • 85.03 (n)
(Ornithorhynchus anatinus)
Mammalia RNF157 35
  • 82 (a)
(Gallus gallus)
Aves RNF157 34 35
  • 78.72 (n)
(Anolis carolinensis)
Reptilia RNF157 35
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf157 34
  • 72.4 (n)
(Danio rerio)
Actinopterygii si:dkey-49c17.3 34
  • 70.97 (n)
RNF157 35
  • 70 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9941 35
  • 29 (a)
(Caenorhabditis elegans)
Secernentea C11H1.3 35
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 41 (a)
Species where no ortholog for RNF157 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RNF157 Gene

Gene Tree for RNF157 (if available)
Gene Tree for RNF157 (if available)

Paralogs for RNF157 Gene

Paralogs for RNF157 Gene

(1) SIMAP similar genes for RNF157 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with RNF157: view

Variants for RNF157 Gene

Sequence variations from dbSNP and Humsavar for RNF157 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000050774 -- 76,144,509(+) TCGCC(A/G)TGTTA intron-variant, utr-variant-3-prime
rs1000063858 -- 76,217,754(+) ATTTG(C/T)TAACG intron-variant
rs1000083361 -- 76,195,684(+) ATGCA(A/G)CAATG intron-variant
rs1000108575 -- 76,178,752(+) GAAAA(A/C)AGAGG intron-variant
rs1000109133 -- 76,188,417(+) TTCTG(C/T)ATTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNF157 Gene

Variant ID Type Subtype PubMed ID
esv26992 CNV loss 19812545
esv3358456 CNV insertion 20981092
esv3641276 CNV loss 21293372
esv3641277 CNV loss 21293372
esv3641278 OTHER inversion 21293372
nsv2144 CNV insertion 18451855
nsv828104 CNV loss 20364138
nsv833546 CNV loss 17160897
nsv833547 CNV loss 17160897
nsv978462 CNV duplication 23825009

Variation tolerance for RNF157 Gene

Residual Variation Intolerance Score: 63.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.55; 55.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNF157 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF157 Gene

Disorders for RNF157 Gene

Relevant External Links for RNF157

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RNF157 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF157 Gene

Publications for RNF157 Gene

  1. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PMID: 11572484) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  4. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 46 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for RNF157 Gene

Sources for RNF157 Gene

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