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RNF157 Gene

protein-coding   GIFtS: 50
GCID: GC17M074138

Ring Finger Protein 157

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ring Finger Protein 1571 2
KIAA19173

External Ids:    HGNC: 294021   Entrez Gene: 1148042   Ensembl: ENSG000001415767   UniProtKB: Q96PX13   

Export aliases for RNF157 gene to outside databases

Previous GC identifers: GC17M074738 GC17M071651 GC17M069567


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RNF157 Gene:
RNF157 (ring finger protein 157) is a protein-coding gene. An important paralog of this gene is MGRN1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RNF157 gene promoter:
         Bach1   COUP-TF1   COUP   HNF-4alpha2   Evi-1   GATA-1   HNF-4alpha1   JunD   COUP-TF   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNF157 promoter sequence
   Search Chromatin IP Primers for RNF157

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNF157


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.1   Ensembl cytogenetic band:  17q25.1   HGNC cytogenetic band: 17q25.3

RNF157 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF157 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M074138:  view genomic region     (about GC identifiers)

Start:
74,138,534 bp from pter      End:
74,236,454 bp from pter
Size:
97,921 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RN157_HUMAN, Q96PX1 (See protein sequence)
Recommended Name: RING finger protein 157  
Size: 679 amino acids; 73579 Da
Sequence caution: Sequence=BAB67810.2; Type=Erroneous initiation; Sequence=BAB71053.1; Type=Erroneous initiation;
Sequence=BAC03669.1; Type=Erroneous initiation;
Secondary accessions: Q8NB72 Q96N56
Alternative splicing: 2 isoforms:  Q96PX1-1   Q96PX1-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RNF157: NX_Q96PX1

Explore proteomics data for RNF157 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RNF157 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_443148.1  
    ENSEMBL proteins: 
     ENSP00000269391   ENSP00000321837   ENSP00000468099   ENSP00000467096   ENSP00000465543  

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    antibodies-online proteins for RNF157 (2 products) 

     
    antibodies-online peptides for RNF157

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    antibodies-online antibodies for RNF157 (10 products) 

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    antibodies-online kits for RNF157 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers

    2 InterPro protein domains:
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q96PX1

    ProtoNet protein and cluster: Q96PX1

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: RN157_HUMAN, Q96PX1
    Similarity: Contains 1 RING-type zinc finger


    Find genes that share domains with RNF157           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with RNF157           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for RNF157:
     Increased cell death HMECs cel 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for RNF157

    miRNA
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    miRTarBase miRNAs that target RNF157:
    hsa-mir-18a-5p (MIRT050735), hsa-mir-335-5p (MIRT017355)

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    Selected qRT-PCR Assays for microRNAs that regulate RNF157 (see all 49):
    hsa-miR-21* hsa-miR-579 hsa-miR-4328 hsa-miR-25 hsa-miR-30d hsa-miR-10b* hsa-miR-4314 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidRNF157 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    extracellular1
    golgi apparatus1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RNF157
    Interactions:

        Search GeneGlobe Interaction Network for RNF157

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for RNF157 (Q96PX13 ENSP000002693914) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE2G2P606043, ENSP000003383484I2D: score=2 STRING: ENSP00000338348
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RNF157 (RN157)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RNF157 gene: 
    NM_052916.2  

    Unigene Cluster for RNF157:

    Ring finger protein 157
    Hs.500643  [show with all ESTs]
    Unigene Representative Sequence: NM_052916
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000269391(uc002jqz.3 uc002jra.3) ENST00000589912 ENST00000319945
    ENST00000589317 ENST00000591355 ENST00000592869 ENST00000593155 ENST00000591615
    ENST00000592271
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate RNF157 (see all 49):
    hsa-miR-21* hsa-miR-579 hsa-miR-4328 hsa-miR-25 hsa-miR-30d hsa-miR-10b* hsa-miR-4314 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidRNF157 3' UTR sequence
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF157
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    OriGene qSTAR qPCR primer pairs in human, mouse for RNF157
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      QuantiTect SYBR Green Assays in human, mouse, rat RNF157
      QuantiFast Probe-based Assays in human, mouse, rat RNF157

    Additional mRNA sequence: 

    AB067504.2 AK055949.1 AK091467.1 BC004231.2 BC042501.1 

    8 DOTS entries:

    DT.430822  DT.454843  DT.100876026  DT.91723928  DT.92040393  DT.95168602  DT.100678850  DT.95168601 

    Selected AceView cDNA sequences (see all 142):

    BQ051891 BM310333 H56536 AA452336 AI950282 BU730168 BM273245 BC004231 
    AW665825 CA393392 AA609142 AI522091 BM725674 AA371906 BQ477762 BE672075 
    BQ431935 AI417834 BM662636 BF056204 BX109616 BQ637165 BM450576 AW445110 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RNF157 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTCTTAAAA
    RNF157 Expression
    About this image


    RNF157 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Eye (Sensory Organs)
    RNF157 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RNF157 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.500643
        Custom PCR Arrays for RNF157
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF157

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RNF157 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnf1571 , 5 ring finger protein 1571, 5 87.86(n)1
    93.07(a)1
      11 (81.17 cM)5
    2173401  NM_027258.11  NP_081534.11 
     1163363535 
    chicken
    (Gallus gallus)
    Aves RNF1571 ring finger protein 157 78.72(n)
    84.58(a)
      429219  XM_004946122.1  XP_004946179.1 
    lizard
    (Anolis carolinensis)
    Reptilia RNF1576
    ring finger protein 157
    84(a)
    1 ↔ 1
    2(112843417-113003341)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia rnf1571 ring finger protein 157 72.4(n)
    79.87(a)
      779801  NM_001078880.1  NP_001072348.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-49c17.31 si:dkey-49c17.3 70.97(n)
    74.16(a)
      555415  XM_005156347.1  XP_005156404.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG99416
    --
    29(a)
    1 → many
    X(13612767-13616058)
    worm
    (Caenorhabditis elegans)
    Secernentea C11H1.36
    Protein C11H1.3 (C11H1.3) mRNA, complete cds
    30(a)
    1 → many
    X(14307863-14311683) WBGene00007529


    ENSEMBL Gene Tree for RNF157 (if available)
    TreeFam Gene Tree for RNF157 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RNF157 gene
    MGRN12  
    1 SIMAP similar gene for RNF157 using alignment to 5 protein entries:     RN157_HUMAN (see all proteins):
    MGRN1

    Find genes that share paralogs with RNF157           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RNF157 (see all 1847)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2005951901,2
    --74151290(+) CTCCTC/TTGGTT 1 -- int10--------
    rs1461634831,2
    C--74151314(+) ACCACC/TCCGTG 1 -- int10--------
    rs2000202301,2
    --74151318(+) CTCCGC/TGCTGT 1 -- int10--------
    rs2015011481,2
    C--74151324(+) GCTGTT/AGGGGT 1 -- int11Minor allele frequency- A:0.00EU 1299
    rs1895591331,2
    C--74151353(+) TCCAGA/CTGGGA 2 A S mis10--------
    rs733455931,2
    C,F--74151396(+) GGCAGC/ACCCTG 2 /G syn12Minor allele frequency- A:0.00WA NA 4554
    rs1498380031,2
    C--74151403(+) CCTGCA/CGAAGA 1 -- int10--------
    rs8945441,2
    C,F,A,H--74151456(+) AAACCC/TAAACC 1 -- int125Minor allele frequency- T:0.07NA EA MN NS WA 3116
    rs1137665471,2
    C,F--74151477(+) CAAAAC/TTGGTG 1 -- int12Minor allele frequency- T:0.50CSA 4
    rs1821750651,2
    C--74151594(+) GGACAC/TGTGCA 1 -- int10--------

    HapMap Linkage Disequilibrium report for RNF157 (74138534 - 74236454 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for RNF157:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv2144CNV Insertion18451855
    nsv833547CNV Loss17160897
    nsv833546CNV Loss17160897
    dgv3271n71CNV Loss21882294
    nsv828104CNV Loss20364138
    esv26992CNV Loss19812545
    nsv908824CNV Loss21882294
    dgv3270n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with RNF157           About GenesLikeMe

    Genetic Association Database (GAD): RNF157
    Human Genome Epidemiology (HuGE) Navigator: RNF157 (5 documents)

    Export disorders for RNF157 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RNF157 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with RNF157)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PubMed id 11572484)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2001)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Strategy for comprehensive identification of human N-myristoylated proteins using an insect cell-free protein synthesis system. (PubMed id 20213681)2 Suzuki T.... Utsumi T. (Proteomics 2010)
    7. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    8. A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. (PubMed id 19690564)1 van Wijk S.J....Timmers H.T. (Mol. Syst. Biol. 2009)
    9. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)
    10. Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study. (PubMed id 17903303)4 O'Donnell C.J....Demissie S. (BMC Med. Genet. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 114804 HGNC: 29402 AceView: RNF157 Ensembl:ENSG00000141576 euGenes: HUgn114804
    ECgene: RNF157 H-InvDB: RNF157

    (According to HUGE)
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    HUGE: KIAA1917

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RNF157 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RNF157 gene:
    Search GeneIP for patents involving RNF157

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