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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RNF152 Gene

protein-coding   GIFtS: 46
GCID: GC18M059475

ring finger protein 152
  Search for RNF152
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RNF152    

Aliases
for RNF152 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Ring Finger Protein 1521 2 3
FLJ391761
E3 Ubiquitin-Protein Ligase RNF1522
EC 6.3.2.-3

External Ids:    HGNC: 268111   Entrez Gene: 2204412   Ensembl: ENSG000001766417   UniProtKB: Q8N8N03   

Export aliases for RNF152 gene to outside databases

Previous GC identifers: GC18M057629 GC18M057631 GC18M056192


Summaries
for RNF152 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: RN152_HUMAN, Q8N8N0
Function: E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of target proteins and their
subsequent targeting to the proteasome for degradation. Induces apoptosis when overexpressed




Genomic Views
for RNF152 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NC_018929.1  NT_025028.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RNF152 gene promoter:
         Olf-1   POU6F1 (c2)   Cdc5   NF-AT   Gfi-1   NF-AT4   NF-AT2   NF-AT3   ZIC2/Zic2   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RNF152 promoter sequence
   Search SABiosciences Chromatin IP Primers for RNF152

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF152


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21.33   Ensembl cytogenetic band:  18q21.33   HGNC cytogenetic band: 18q21.33

RNF152 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF152 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M059475:  view genomic region     (about GC identifiers)

Start:
 59,475,296 bp from pter      End:
 59,561,480 bp from pter
Size:
 86,185 bases      Orientation:
 minus strand

Proteins
for RNF152 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RN152_HUMAN, Q8N8N0 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase RNF152  
Size: 203 amino acids; 22357 Da
Subcellular location: Lysosome membrane; Single-pass membrane protein (Probable)
Secondary accessions: B3KV99 Q52LA4

Explore the universe of human proteins at neXtProt for RNF152: NX_Q8N8N0

Post-translational modifications:

  • Ubiquitinated. Autoubiquitinated in vitro, leading to its degradation by the proteasome (Probable)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8N8N0

    • RNF152 Protein expression data from MOPED and PaxDb:    About this image 
    RNF152 Protein Expression
    REFSEQ proteins: NP_775828.1  
    ENSEMBL proteins: 
     ENSP00000316628   ENSP00000466492  

    Human Recombinant Protein Products for RNF152: 
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    Novus Biologicals RNF152 Protein
    Novus Biologicals RNF152 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for RNF152

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005764lysosome IDA--
    GO:0005765lysosomal membrane IEA--
    GO:0016021integral to membrane IEA--

    RNF152 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for RNF152

    Protein Domains /
    Families
    for RNF152 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RNF152 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR001841 Znf_RING
     IPR018957 Znf_C3HC4_RING-type
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q8N8N0

    ProtoNet protein and cluster: Q8N8N0

    1 Blocks protein family: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: RN152_HUMAN, Q8N8N0
    Similarity: Belongs to the RNF152 family
    Similarity: Contains 1 RING-type zinc finger


    Function
    for RNF152 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RN152_HUMAN, Q8N8N0
    Function: E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of target proteins and their
    subsequent targeting to the proteasome for degradation. Induces apoptosis when overexpressed

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IDA--
    GO:0008270zinc ion binding IEA--
         
    RNF152 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for RNF152:
     Decreased Hepatitis C virus re  Decreased number of cells in m  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for RNF152 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RNF152
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate RNF152:
    hsa-miR-138-1* hsa-miR-135b hsa-miR-137 hsa-miR-1303 hsa-miR-1271 hsa-miR-96 hsa-miR-135a
    SwitchGear 3'UTR luciferase reporter plasmid: RNF152 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF152


    Pathways & Interactions
    for RNF152 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    UniProtKB/Swiss-Prot: RN152_HUMAN, Q8N8N0
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNF152

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for RNF152 (Q8N8N03 ENSP000003166284) via UniProtKB, MINT, STRING, and/or I2D

    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE2NP610883, ENSP000003161764I2D: score=2 STRING: ENSP00000316176
    UBE2WQ96B023, ENSP000003974534I2D: score=2 STRING: ENSP00000397453
    UBE2E1P519653, ENSP000003037094I2D: score=2 STRING: ENSP00000303709
    CROCCENSP000003646914STRING: ENSP00000364691
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process TAS--
    GO:0070936protein K48-linked ubiquitination IDA--

    RNF152 for ontologies           About GeneDecksing



    Drugs & Compounds
    for RNF152 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RNF152
    Search CenterWatch for drugs/clinical trials and news about RNF152 / RN152 

    Transcripts
    for RNF152 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RNF152 gene: 
    NM_173557.2  

    Unigene Cluster for RNF152:

    Ring finger protein 152
    Hs.667457  [show with all ESTs]
    Unigene Representative Sequence: AK122758
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000312828(uc002lih.1) ENST00000591306 ENST00000588064 ENST00000588396


    miRNA
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    7 QIAGEN miScript miRNA Assays for microRNAs that regulate RNF152:
    hsa-miR-138-1* hsa-miR-135b hsa-miR-137 hsa-miR-1303 hsa-miR-1271 hsa-miR-96 hsa-miR-135a
    SwitchGear 3'UTR luciferase reporter plasmid: RNF152 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RNF152 (see all 7)
    OriGene shRNA RFP: RNF152
    OriGene siRNA: RNF152
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    Sirion Biotech Custom design and validation of potent shRNA sequences against RNF152 
    Clone
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNF152

    Additional cDNA sequence: 

    AK122758.1 BC094004.1 BC111956.1 

    2 DOTS entries:

    DT.86850209  DT.70101203 

    18 AceView cDNA sequences:

    AW301696 BI517305 AK096495 NM_173557 AW058471 BX645692 AI190795 BQ717719 
    CB265330 AI985463 AW263071 BM975578 AK122758 AW242684 AW612358 BG990516 
    BG990514 BI760430 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for RNF152    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b
    SP1:        -           -               
    SP2:                                    
    SP3:                    -               


    ECgene alternative splicing isoforms for RNF152

    Expression
    for RNF152 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RNF152 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGAAAACCTG
    RNF152 Expression
    About this image

    RNF152 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainHypothalamusBrain
    BrainThalamusBrain
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Definitive endoderm-like cells (A scalable, suspensi...)

    See RNF152 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RNF152

    SOURCE GeneReport for Unigene cluster: Hs.667457

    UniProtKB/Swiss-Prot: RN152_HUMAN, Q8N8N0
    Tissue specificity: Widely expressed

        SABiosciences Expression via Pathway-Focused PCR Array including RNF152: 
              Ubiquitin Ligases in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for RNF152 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for RNF152 gene from 3/10 species (see all 10)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves RNF1521 ring finger protein 152 84.73(n)
    93.1(a)    		   420909  XM_418995.3  XP_418995.2 
    lizard
    (Anolis carolinensis)    		 Reptilia RNF1526
    		 --
    		 94(a)
    		 1 ↔ 1
    		 GL343265.1(945366-945977)
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.204552 Transcribed sequence with weak similarity to protein more 73.2(n)    57081344 


    ENSEMBL Gene Tree for RNF152 (if available)
    TreeFam Gene Tree for RNF152 (if available) 

    Paralogs
    for RNF152 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RNF152 gene
    RNF1822  
    3 SIMAP similar genes for RNF152 using alignment to 2 protein entries:     RN152_HUMAN (see all proteins):
    RNF182    TRIM3    SH3RF1

    RNF152 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for RNF152
    PGOHUM00000235955


    Genomic Variants
    for RNF152 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1395 NCBI SNPs in RNF152 are shown (see all 1395)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 18 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1860484441,2
    		--59481863(+) AAAAAC/TGTGTT 1 -- ds50010--------
    rs80926211,2
    		C,F,H--59481916(+) GAATTC/ATAACT 1 -- ds50019Minor allele frequency- A:0.02NS EA NA 1088
    rs1405103101,2
    		--59482112(+) AGAGGA/GGCGAG 1 -- ds50010--------
    rs734563341,2
    		C--59482128(+) CAGGTG/AACGTG 1 -- ds50011Minor allele frequency- A:0.50WA 2
    rs99731811,2
    		C,F,A--59482283(+) CATACA/GCACAC 1 -- ds5001 ese37Minor allele frequency- G:0.24NA CSA WA EA 366
    rs1903141881,2
    		--59482286(+) ACACAC/TACAAA 1 -- ds50010--------
    rs1832772881,2
    		--59482307(+) TTACAA/TTTGAA 1 -- ut310--------
    rs1876045161,2
    		--59482310(+) CATTTA/GAAATT 1 -- ut310--------
    rs1383837041,2
    		--59482330(+) TGAGAC/TGGCTT 1 -- ut310--------
    rs1913723101,2
    		--59482392(+) TTCTCA/GGTTTA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for RNF152 (59475296 - 59561480 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for RNF152: --

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    Disorders / Diseases
    for RNF152 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RNF152 for disorders           About MalaCards

    RNF152 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: RNF152 (1 document)

    Export disorders for RNF152 gene to outside databases

    Publications
    for RNF152 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RNF152 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with RNF152)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. RNF152, a novel lysosome localized E3 ligase with pro-apoptotic activities. (PubMed id 21203937)1, 2 Zhang S.... Tang J. (2010)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. (PubMed id 19690564)1 van Wijk S.J....Timmers H.T. (2009)
    5. Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)1 Trynka G....Wijmenga C. (2009)
    6. DNA sequence and analysis of human chromosome 18. (PubMed id 16177791)2 Nusbaum C.... Lander E.S. (2005)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for RNF152 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
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    Genome Databases showing RNF152 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 220441 HGNC: 26811 AceView: RNF152 Ensembl:ENSG00000176641 euGenes: HUgn220441
    ECgene: RNF152 H-InvDB: RNF152

    Other Databases showing RNF152 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RNF152 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RNF152 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for RNF152 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RNF152 gene:
    Search GeneIP for patents involving RNF152

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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