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Aliases for RNF152 Gene

Aliases for RNF152 Gene

  • Ring Finger Protein 152 2 3
  • RING Finger Protein 152 4
  • EC 6.3.2.- 4

External Ids for RNF152 Gene

Summaries for RNF152 Gene

GeneCards Summary for RNF152 Gene

RNF152 (Ring Finger Protein 152) is a Protein Coding gene. GO annotations related to this gene include ubiquitin-protein transferase activity.

UniProtKB/Swiss-Prot for RNF152 Gene

  • E3 ubiquitin-protein ligase mediating Lys-48-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation. Induces apoptosis when overexpressed.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF152 Gene

Genomics for RNF152 Gene

Genomic Location for RNF152 Gene

Start:
61,808,063 bp from pter
End:
61,894,401 bp from pter
Size:
86,339 bases
Orientation:
Minus strand

Genomic View for RNF152 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNF152 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF152 Gene

Regulatory Elements for RNF152 Gene

Proteins for RNF152 Gene

  • Protein details for RNF152 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N8N0-RN152_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase RNF152
    Protein Accession:
    Q8N8N0
    Secondary Accessions:
    • B3KV99
    • Q52LA4

    Protein attributes for RNF152 Gene

    Size:
    203 amino acids
    Molecular mass:
    22357 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RNF152 Gene

Proteomics data for RNF152 Gene at MOPED

Post-translational modifications for RNF152 Gene

  • Ubiquitinated. Autoubiquitinated in vitro, leading to its degradation by the proteasome (Probable).

Other Protein References for RNF152 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RNF152 Gene

Domains for RNF152 Gene

Gene Families for RNF152 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for RNF152 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

RN152_HUMAN
Family:
  • Belongs to the RNF152 family.:
    • Q8N8N0
Similarity:
  • Contains 1 RING-type zinc finger.:
    • Q8N8N0
genes like me logo Genes that share domains with RNF152: view

Function for RNF152 Gene

Molecular function for RNF152 Gene

UniProtKB/Swiss-Prot Function: E3 ubiquitin-protein ligase mediating Lys-48-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation. Induces apoptosis when overexpressed.

Enzyme Numbers (IUBMB) for RNF152 Gene

Gene Ontology (GO) - Molecular Function for RNF152 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 21203937
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with RNF152: view
genes like me logo Genes that share phenotypes with RNF152: view

miRNA for RNF152 Gene

miRTarBase miRNAs that target RNF152

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for RNF152 Gene

Localization for RNF152 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF152 Gene

Lysosome membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNF152 Gene COMPARTMENTS Subcellular localization image for RNF152 gene
Compartment Confidence
lysosome 5
vacuole 5
plasma membrane 3
cytosol 2
extracellular 1
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RNF152 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IDA 21203937
GO:0005765 lysosomal membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RNF152: view

Pathways for RNF152 Gene

SuperPathways for RNF152 Gene

No Data Available

UniProtKB/Swiss-Prot Q8N8N0-RN152_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Interacting Proteins for RNF152 Gene

Gene Ontology (GO) - Biological Process for RNF152 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process TAS 21203937
GO:0070936 protein K48-linked ubiquitination IDA 21203937
genes like me logo Genes that share ontologies with RNF152: view

No data available for Pathways by source for RNF152 Gene

Transcripts for RNF152 Gene

mRNA/cDNA for RNF152 Gene

Unigene Clusters for RNF152 Gene

Ring finger protein 152:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNF152 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP1: - -
SP2:
SP3: -

Relevant External Links for RNF152 Gene

GeneLoc Exon Structure for
RNF152
ECgene alternative splicing isoforms for
RNF152

Expression for RNF152 Gene

mRNA expression in normal human tissues for RNF152 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNF152 Gene

This gene is overexpressed in Kidney - Cortex (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RNF152 Gene

SOURCE GeneReport for Unigene cluster for RNF152 Gene Hs.667457

mRNA Expression by UniProt/SwissProt for RNF152 Gene

Q8N8N0-RN152_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with RNF152: view

Orthologs for RNF152 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNF152 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNF152 36
  • 99.18 (n)
  • 100 (a)
RNF152 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RNF152 36
  • 83.64 (n)
  • 82.73 (a)
dog
(Canis familiaris)
Mammalia LOC609935 36
  • 90.8 (n)
  • 94.58 (a)
RNF152 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnf152 36
  • 88.18 (n)
  • 97.54 (a)
Rnf152 16
Rnf152 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RNF152 37
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RNF152 37
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnf152 36
  • 88.01 (n)
  • 97.54 (a)
chicken
(Gallus gallus)
Aves RNF152 36
  • 84.73 (n)
  • 93.1 (a)
RNF152 37
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RNF152 37
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486837 36
  • 72.58 (n)
  • 88.67 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7669 36
zebrafish
(Danio rerio)
Actinopterygii Dr.20455 36
rnf152 36
  • 66.16 (n)
  • 61.22 (a)
rnf152 37
  • 60 (a)
OneToOne
Species with no ortholog for RNF152:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF152 Gene

ENSEMBL:
Gene Tree for RNF152 (if available)
TreeFam:
Gene Tree for RNF152 (if available)

Paralogs for RNF152 Gene

Selected SIMAP similar genes for RNF152 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for RNF152 Gene

genes like me logo Genes that share paralogs with RNF152: view

No data available for Paralogs for RNF152 Gene

Variants for RNF152 Gene

Sequence variations from dbSNP and Humsavar for RNF152 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs1133216 -- 61,886,127(-) GCAGT(A/G)CGTAT intron-variant
rs1135529 -- 61,808,353(-) GCTGC(C/T)GGGCT utr-variant-3-prime
rs1142939 -- 61,815,385(-) TTTTT(C/T)TTTTT utr-variant-3-prime
rs4072460 -- 61,867,925(-) TAATA(A/G)TAAAG intron-variant
rs4073064 -- 61,865,494(-) GTCAC(A/G)TGGAT intron-variant

Relevant External Links for RNF152 Gene

HapMap Linkage Disequilibrium report
RNF152

No data available for Structural Variations from Database of Genomic Variants (DGV) for RNF152 Gene

Disorders for RNF152 Gene

Relevant External Links for RNF152

Genetic Association Database (GAD)
RNF152
Human Genome Epidemiology (HuGE) Navigator
RNF152
genes like me logo Genes that share disorders with RNF152: view

No data available for UniProtKB/Swiss-Prot for RNF152 Gene

Publications for RNF152 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 49
  4. RNF152, a novel lysosome localized E3 ligase with pro-apoptotic activities. (PMID: 21203937) Zhang S. … Tang J. (Protein Cell 2010) 3 4
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3

Products for RNF152 Gene

Sources for RNF152 Gene

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