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Aliases for RNF152 Gene

Aliases for RNF152 Gene

  • Ring Finger Protein 152 2 3
  • RING Finger Protein 152 4 5
  • RING-Type E3 Ubiquitin Transferase RNF152 4
  • EC 2.3.2.27 4

External Ids for RNF152 Gene

Previous GeneCards Identifiers for RNF152 Gene

  • GC18M057629
  • GC18M057631
  • GC18M059475
  • GC18M056192

Summaries for RNF152 Gene

GeneCards Summary for RNF152 Gene

RNF152 (Ring Finger Protein 152) is a Protein Coding gene. Among its related pathways are Protein ubiquitination and mTOR signaling pathway (KEGG). GO annotations related to this gene include ligase activity and ubiquitin-protein transferase activity.

UniProtKB/Swiss-Prot for RNF152 Gene

  • E3 ubiquitin-protein ligase mediating Lys-63-linked polyubiquitination of RRAGA in response to amino acid starvation. Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability (PubMed:25936802). Also mediates Lys-48-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation. Induces apoptosis when overexpressed (PubMed:21203937).

Additional gene information for RNF152 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF152 Gene

Genomics for RNF152 Gene

Regulatory Elements for RNF152 Gene

Enhancers for RNF152 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18H061731 1.3 FANTOM5 Ensembl ENCODE 15.1 +160.3 160284 5 FOXA2 TAF1 MAX RAD21 YY1 HNF4G FOS HLF REST GABPA RNF152 ENSG00000267038 KIAA1468 GC18M061737
GH18H061604 1.2 Ensembl ENCODE dbSUPER 10.6 +288.0 287951 3 TAL1 JUN CHD1 GABPA ETS1 FOSL1 TCF12 JUND POLR2A SMARCA4 RNF152 ENSG00000267279 ENSG00000267316
GH18H061635 1 Ensembl ENCODE 11.5 +257.8 257763 2 CTCF ZNF76 MAX RAD21 YY1 GATA3 SMC3 ZNF143 PRDM10 ZNF654 RNF152 ENSG00000267279 GC18M061638 LSM6P1
GH18H061869 0.9 FANTOM5 Ensembl ENCODE 12.2 +24.1 24053 1 FOXP2 RNF152 CDH20 PHLPP1 GC18M061809
GH18H061602 0.8 Ensembl ENCODE dbSUPER 10.6 +291.6 291613 1 RNF152 ENSG00000267279 ENSG00000267316
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RNF152 on UCSC Golden Path with GeneCards custom track

Promoters for RNF152 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000104319 532 2201 CTCF MXI1 KLF1 ZNF777 RB1 MAX RAD21 ZFHX2 GLIS2 POLR2A

Genomic Location for RNF152 Gene

Chromosome:
18
Start:
61,808,063 bp from pter
End:
61,894,432 bp from pter
Size:
86,370 bases
Orientation:
Minus strand

Genomic View for RNF152 Gene

Genes around RNF152 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF152 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF152 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF152 Gene

Proteins for RNF152 Gene

  • Protein details for RNF152 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N8N0-RN152_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase RNF152
    Protein Accession:
    Q8N8N0
    Secondary Accessions:
    • B3KV99
    • Q52LA4

    Protein attributes for RNF152 Gene

    Size:
    203 amino acids
    Molecular mass:
    22357 Da
    Quaternary structure:
    • Interacts with RRAGA (inactive GDP-bound form); stimulated by amino acid starvation.

neXtProt entry for RNF152 Gene

Post-translational modifications for RNF152 Gene

  • Ubiquitinated. Autoubiquitinated in vitro, leading to its degradation by the proteasome (Probable).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RNF152 Gene

No data available for DME Specific Peptides for RNF152 Gene

Domains & Families for RNF152 Gene

Gene Families for RNF152 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for RNF152 Gene

Suggested Antigen Peptide Sequences for RNF152 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N8N0

UniProtKB/Swiss-Prot:

RN152_HUMAN :
  • Belongs to the RNF152 family.
Family:
  • Belongs to the RNF152 family.
genes like me logo Genes that share domains with RNF152: view

Function for RNF152 Gene

Molecular function for RNF152 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase mediating Lys-63-linked polyubiquitination of RRAGA in response to amino acid starvation. Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability (PubMed:25936802). Also mediates Lys-48-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation. Induces apoptosis when overexpressed (PubMed:21203937).

Enzyme Numbers (IUBMB) for RNF152 Gene

Phenotypes From GWAS Catalog for RNF152 Gene

Gene Ontology (GO) - Molecular Function for RNF152 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 21203937
GO:0016740 transferase activity IEA --
GO:0031267 small GTPase binding IPI 25936802
GO:0046872 metal ion binding IEA --
GO:0061630 ubiquitin protein ligase activity IMP,IEA 25936802
genes like me logo Genes that share ontologies with RNF152: view
genes like me logo Genes that share phenotypes with RNF152: view

Animal Model Products

CRISPR Products

miRNA for RNF152 Gene

miRTarBase miRNAs that target RNF152

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RNF152
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNF152 Gene

Localization for RNF152 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF152 Gene

Lysosome membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNF152 gene
Compartment Confidence
lysosome 5
plasma membrane 3
cytosol 2
extracellular 1
nucleus 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for RNF152 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IDA,IEA 21203937
GO:0005765 lysosomal membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031301 integral component of organelle membrane IMP 25936802
genes like me logo Genes that share ontologies with RNF152: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RNF152 Gene

Pathways & Interactions for RNF152 Gene

genes like me logo Genes that share pathways with RNF152: view

Pathways by source for RNF152 Gene

UniProtKB/Swiss-Prot Q8N8N0-RN152_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Interacting Proteins for RNF152 Gene

Gene Ontology (GO) - Biological Process for RNF152 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process TAS,IEA 21203937
GO:0010508 positive regulation of autophagy IMP,IEA 25936802
GO:0016567 protein ubiquitination TAS --
GO:0034198 cellular response to amino acid starvation IEA,IDA 25936802
GO:0070534 protein K63-linked ubiquitination IMP 25936802
genes like me logo Genes that share ontologies with RNF152: view

No data available for SIGNOR curated interactions for RNF152 Gene

Drugs & Compounds for RNF152 Gene

No Compound Related Data Available

Transcripts for RNF152 Gene

Unigene Clusters for RNF152 Gene

Ring finger protein 152:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RNF152
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for RNF152 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP1: - -
SP2:
SP3: -

Relevant External Links for RNF152 Gene

GeneLoc Exon Structure for
RNF152
ECgene alternative splicing isoforms for
RNF152

Expression for RNF152 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNF152 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNF152 Gene

This gene is overexpressed in Kidney - Cortex (x4.0).

Protein differential expression in normal tissues from HIPED for RNF152 Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RNF152 Gene



Protein tissue co-expression partners for RNF152 Gene

NURSA nuclear receptor signaling pathways regulating expression of RNF152 Gene:

RNF152

SOURCE GeneReport for Unigene cluster for RNF152 Gene:

Hs.667457

mRNA Expression by UniProt/SwissProt for RNF152 Gene:

Q8N8N0-RN152_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for RNF152 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with RNF152: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for RNF152 Gene

Orthologs for RNF152 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNF152 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNF152 33 34
  • 99.18 (n)
dog
(Canis familiaris)
Mammalia RNF152 34
  • 95 (a)
OneToOne
LOC609935 33
  • 90.8 (n)
oppossum
(Monodelphis domestica)
Mammalia RNF152 34
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RNF152 34
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnf152 33 16 34
  • 88.18 (n)
rat
(Rattus norvegicus)
Mammalia Rnf152 33
  • 88.01 (n)
cow
(Bos Taurus)
Mammalia RNF152 33
  • 83.64 (n)
chicken
(Gallus gallus)
Aves RNF152 33 34
  • 84.73 (n)
lizard
(Anolis carolinensis)
Reptilia RNF152 34
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486837 33
  • 72.58 (n)
zebrafish
(Danio rerio)
Actinopterygii rnf152 33 34
  • 66.16 (n)
Dr.20455 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7669 33
Species where no ortholog for RNF152 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF152 Gene

ENSEMBL:
Gene Tree for RNF152 (if available)
TreeFam:
Gene Tree for RNF152 (if available)

Paralogs for RNF152 Gene

(3) SIMAP similar genes for RNF152 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for RNF152 Gene

genes like me logo Genes that share paralogs with RNF152: view

No data available for Paralogs for RNF152 Gene

Variants for RNF152 Gene

Sequence variations from dbSNP and Humsavar for RNF152 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1000014159 -- 61,856,379(+) GGAAC(C/T)CATCT intron-variant
rs1000066455 -- 61,856,741(+) AAAAG(C/T)GGATT intron-variant
rs1000076826 -- 61,859,510(+) TGCAG(A/G)GAAAA intron-variant
rs1000082760 -- 61,850,438(+) AGAAT(C/T)ATTCT intron-variant
rs1000092058 -- 61,818,252(+) ACCCT(A/G)TCTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNF152 Gene

Variant ID Type Subtype PubMed ID
nsv961055 CNV duplication 23825009

Variation tolerance for RNF152 Gene

Residual Variation Intolerance Score: 36.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.11; 38.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNF152 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNF152

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF152 Gene

Disorders for RNF152 Gene

Relevant External Links for RNF152

Genetic Association Database (GAD)
RNF152
Human Genome Epidemiology (HuGE) Navigator
RNF152
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RNF152

No disorders were found for RNF152 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF152 Gene

Publications for RNF152 Gene

  1. The ubiquitination of rag A GTPase by RNF152 negatively regulates mTORC1 activation. (PMID: 25936802) Deng L … Wang P (Molecular cell 2015) 3 4 60
  2. RNF152, a novel lysosome localized E3 ligase with pro-apoptotic activities. (PMID: 21203937) Zhang S … Tang J (Protein & cell 2010) 3 4 60
  3. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 45 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for RNF152 Gene

Sources for RNF152 Gene

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