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Aliases for RNF152 Gene

Aliases for RNF152 Gene

  • Ring Finger Protein 152 2 3
  • RING Finger Protein 152 4
  • EC 6.3.2.- 4

External Ids for RNF152 Gene

Previous GeneCards Identifiers for RNF152 Gene

  • GC18M057629
  • GC18M057631
  • GC18M059475
  • GC18M056192

Summaries for RNF152 Gene

GeneCards Summary for RNF152 Gene

RNF152 (Ring Finger Protein 152) is a Protein Coding gene. GO annotations related to this gene include ligase activity and ubiquitin-protein transferase activity.

UniProtKB/Swiss-Prot for RNF152 Gene

  • E3 ubiquitin-protein ligase mediating Lys-63-linked polyubiquitination of RRAGA in response to amino acid starvation. Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability (PubMed:25936802). Also mediates Lys-48-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation. Induces apoptosis when overexpressed (PubMed:21203937).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF152 Gene

Genomics for RNF152 Gene

Regulatory Elements for RNF152 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RNF152 Gene

Chromosome:
18
Start:
61,808,063 bp from pter
End:
61,894,432 bp from pter
Size:
86,370 bases
Orientation:
Minus strand

Genomic View for RNF152 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for RNF152 Gene

Proteins for RNF152 Gene

  • Protein details for RNF152 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N8N0-RN152_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase RNF152
    Protein Accession:
    Q8N8N0
    Secondary Accessions:
    • B3KV99
    • Q52LA4

    Protein attributes for RNF152 Gene

    Size:
    203 amino acids
    Molecular mass:
    22357 Da
    Quaternary structure:
    • Interacts with RRAGA (inactive GDP-bound form); stimulated by amino acid starvation.

neXtProt entry for RNF152 Gene

Proteomics data for RNF152 Gene at MOPED

Post-translational modifications for RNF152 Gene

  • Ubiquitinated. Autoubiquitinated in vitro, leading to its degradation by the proteasome (Probable).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RNF152 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RNF152 Gene

Domains & Families for RNF152 Gene

Gene Families for RNF152 Gene

Protein Domains for RNF152 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for RNF152 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N8N0

UniProtKB/Swiss-Prot:

RN152_HUMAN :
  • Belongs to the RNF152 family.
  • Contains 1 RING-type zinc finger.
Family:
  • Belongs to the RNF152 family.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF152: view

Function for RNF152 Gene

Molecular function for RNF152 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase mediating Lys-63-linked polyubiquitination of RRAGA in response to amino acid starvation. Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability (PubMed:25936802). Also mediates Lys-48-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation. Induces apoptosis when overexpressed (PubMed:21203937).

Enzyme Numbers (IUBMB) for RNF152 Gene

Gene Ontology (GO) - Molecular Function for RNF152 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 21203937
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0031267 small GTPase binding IPI 25936802
genes like me logo Genes that share ontologies with RNF152: view
genes like me logo Genes that share phenotypes with RNF152: view

Animal Model Products

miRNA for RNF152 Gene

miRTarBase miRNAs that target RNF152

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for RNF152 Gene

Localization for RNF152 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF152 Gene

Lysosome membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNF152 Gene COMPARTMENTS Subcellular localization image for RNF152 gene
Compartment Confidence
lysosome 5
vacuole 5

Gene Ontology (GO) - Cellular Components for RNF152 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IDA 21203937
GO:0005765 lysosomal membrane IDA 25936802
GO:0031301 integral component of organelle membrane IMP 25936802
genes like me logo Genes that share ontologies with RNF152: view

Pathways & Interactions for RNF152 Gene

SuperPathways for RNF152 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q8N8N0-RN152_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Interacting Proteins for RNF152 Gene

Gene Ontology (GO) - Biological Process for RNF152 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process TAS 21203937
GO:0010508 positive regulation of autophagy IMP 25936802
GO:0034198 cellular response to amino acid starvation IDA 25936802
GO:0070534 protein K63-linked ubiquitination IMP 25936802
GO:0070936 protein K48-linked ubiquitination IDA 21203937
genes like me logo Genes that share ontologies with RNF152: view

No data available for Pathways by source and SIGNOR curated interactions for RNF152 Gene

Drugs & Compounds for RNF152 Gene

No Compound Related Data Available

Transcripts for RNF152 Gene

mRNA/cDNA for RNF152 Gene

Unigene Clusters for RNF152 Gene

Ring finger protein 152:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNF152 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP1: - -
SP2:
SP3: -

Relevant External Links for RNF152 Gene

GeneLoc Exon Structure for
RNF152
ECgene alternative splicing isoforms for
RNF152

Expression for RNF152 Gene

mRNA expression in normal human tissues for RNF152 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNF152 Gene

This gene is overexpressed in Kidney - Cortex (x4.0).

Protein differential expression in normal tissues from HIPED for RNF152 Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RNF152 Gene



SOURCE GeneReport for Unigene cluster for RNF152 Gene Hs.667457

mRNA Expression by UniProt/SwissProt for RNF152 Gene

Q8N8N0-RN152_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with RNF152: view

Protein tissue co-expression partners for RNF152 Gene

Primer Products

In Situ Assay Products

Orthologs for RNF152 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNF152 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RNF152 35
  • 83.64 (n)
  • 82.73 (a)
dog
(Canis familiaris)
Mammalia LOC609935 35
  • 90.8 (n)
  • 94.58 (a)
RNF152 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnf152 35
  • 88.18 (n)
  • 97.54 (a)
Rnf152 16
Rnf152 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RNF152 35
  • 99.18 (n)
  • 100 (a)
RNF152 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnf152 35
  • 88.01 (n)
  • 97.54 (a)
oppossum
(Monodelphis domestica)
Mammalia RNF152 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RNF152 36
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves RNF152 35
  • 84.73 (n)
  • 93.1 (a)
RNF152 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RNF152 36
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486837 35
  • 72.58 (n)
  • 88.67 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.20455 35
rnf152 35
  • 66.16 (n)
  • 61.22 (a)
rnf152 36
  • 60 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7669 35
Species with no ortholog for RNF152:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF152 Gene

ENSEMBL:
Gene Tree for RNF152 (if available)
TreeFam:
Gene Tree for RNF152 (if available)

Paralogs for RNF152 Gene

(3) SIMAP similar genes for RNF152 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for RNF152 Gene

genes like me logo Genes that share paralogs with RNF152: view

No data available for Paralogs for RNF152 Gene

Variants for RNF152 Gene

Sequence variations from dbSNP and Humsavar for RNF152 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs1133216 -- 61,886,127(-) GCAGT(A/G)CGTAT intron-variant
rs1135529 -- 61,808,353(-) GCTGC(C/T)GGGCT utr-variant-3-prime
rs1142939 -- 61,815,385(-) TTTTT(C/T)TTTTT utr-variant-3-prime
rs4072460 -- 61,867,925(-) TAATA(A/G)TAAAG intron-variant
rs4073064 -- 61,865,494(-) GTCAC(A/G)TGGAT intron-variant

Variation tolerance for RNF152 Gene

Residual Variation Intolerance Score: 36.91% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.11; 38.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNF152 Gene

HapMap Linkage Disequilibrium report
RNF152

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RNF152 Gene

Disorders for RNF152 Gene

Relevant External Links for RNF152

Genetic Association Database (GAD)
RNF152
Human Genome Epidemiology (HuGE) Navigator
RNF152
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RNF152
genes like me logo Genes that share disorders with RNF152: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF152 Gene

Publications for RNF152 Gene

  1. The ubiquitination of RagA GTPase by RNF152 negatively regulates mTORC1 activation. (PMID: 25936802) Deng L. … Wang P. (Mol. Cell 2015) 67
  2. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 67
  3. RNF152, a novel lysosome localized E3 ligase with pro-apoptotic activities. (PMID: 21203937) Zhang S. … Tang J. (Protein Cell 2010) 67
  4. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 67
  5. A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. (PMID: 19690564) van Wijk S.J. … Timmers H.T. (Mol. Syst. Biol. 2009) 67

Products for RNF152 Gene

Sources for RNF152 Gene

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