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RNF151 Gene

protein-coding   GIFtS: 38
GCID: GC16P002113

Ring Finger Protein 151

  Search for RNF151
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ring Finger Protein 1511 2

External Ids:    HGNC: 232351   Entrez Gene: 1463102   Ensembl: ENSG000001795807   UniProtKB: Q2KHN13   

Export aliases for RNF151 gene to outside databases

Previous GC identifers: GC16P001957 GC16P001958 GC16P001959 GC16P001963 GC16P002017 GC16P002019 GC16P001940 GC16P002024 GC16P002028 GC16P002047 GC16P002054 GC16P002077 GC16P002092


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RNF151 Gene:
RNF151 (ring finger protein 151) is a protein-coding gene. GO annotations related to this gene include ubiquitin-protein ligase activity. An important paralog of this gene is RNF41.

UniProtKB/Swiss-Prot: RN151_HUMAN, Q2KHN1
Function: May be involved in acrosome formation of spermatids




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NT_010393.17  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RNF151 gene promoter:
         SRF   NF-1/L   NF-1   MAZR   Pax-5   SRF (504 AA)   AP-4   NF-kappaB1   c-Ets-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNF151


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

RNF151 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF151 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P002113:  view genomic region     (about GC identifiers)

Start:
2,016,824 bp from pter      End:
2,018,976 bp from pter
Size:
2,153 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RN151_HUMAN, Q2KHN1 (See protein sequence)
Recommended Name: RING finger protein 151  
Size: 245 amino acids; 27412 Da
Subunit: Interacts with DTNBP1 (By similarity)
Secondary accessions: Q8NHS5

Explore the universe of human proteins at neXtProt for RNF151: NX_Q2KHN1

Explore proteomics data for RNF151 at MOPED


See RNF151 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_777563.2  
ENSEMBL proteins: 
 ENSP00000454886   ENSP00000456566   ENSP00000325794  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
RNF: RING-type (C3HC4) zinc fingers

Selected InterPro protein domains (see all 7):
 IPR008974 TRAF-like
 IPR017907 Znf_RING_CS
 IPR001841 Znf_RING
 IPR001293 Znf_TRAF
 IPR013010 Znf_SIAH

Graphical View of Domain Structure for InterPro Entry Q2KHN1

ProtoNet protein and cluster: Q2KHN1

UniProtKB/Swiss-Prot: RN151_HUMAN, Q2KHN1
Similarity: Contains 1 RING-type zinc finger
Similarity: Contains 1 TRAF-type zinc finger


RNF151 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: RN151_HUMAN, Q2KHN1
Function: May be involved in acrosome formation of spermatids

     Gene Ontology (GO): 4 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004842ubiquitin-protein ligase activity IEA--
GO:0005515protein binding ----
GO:0008270zinc ion binding IEA--
GO:0046872metal ion binding ----
     
RNF151 for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for RNF151:
 Decreased viability with pacli 

Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
RN151_HUMAN, Q2KHN1: Cytoplasm (By similarity). Nucleus (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol3
nucleus3

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000151ubiquitin ligase complex ----
GO:0005634nucleus IEA--
GO:0005737cytoplasm IEA--

RNF151 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RNF151
Interactions:

    Search GeneGlobe Interaction Network for RNF151

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5 Interacting proteins for RNF151 (ENSP000003257944) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
COPS3ENSP000002687174STRING: ENSP00000268717
CCNL1ENSP000002959264STRING: ENSP00000295926
CCNL2ENSP000003836114STRING: ENSP00000383611
EIF2AK2ENSP000002330574STRING: ENSP00000233057
EIF2AK3ENSP000003072354STRING: ENSP00000307235
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Gene Ontology (GO): 3 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007283spermatogenesis IEA--
GO:0016567protein ubiquitination ----
GO:0030154cell differentiation IEA--

RNF151 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for RNF151 (RN151)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for RNF151 gene: 
NM_174903.4  

Unigene Cluster for RNF151:

Ring finger protein 151
Hs.99354  [show with all ESTs]
Unigene Representative Sequence: BI461348
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000569210 ENST00000569714(uc002cnt.1) ENST00000321392
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Additional mRNA sequence: 

BC029501.2 BC113014.2 

2 DOTS entries:

DT.70105132  DT.120656710 

13 AceView cDNA sequences:

BE552345 BC029501 AW236968 BI829513 AI653299 BX089545 BI461348 AI798656 
BF057221 AI351074 AJ457801 AI916892 AA453999 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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RNF151 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CCCCCTGGCC
RNF151 Expression
About this image

RNF151 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

RNF151 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.99354
    Custom PCR Arrays for RNF151
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF151

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for RNF151 gene from Selected species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Rnf1511 , 5 ring finger protein 1511, 5 77.83(n)1
71.3(a)1
  17 (12.51 cM)5
675041  NM_026205.31  NP_080481.11 
 247158395 
chicken
(Gallus gallus)
Aves RNF1516
ring finger protein 151
22(a)
1 ↔ 1
2(125907865-125917414)
lizard
(Anolis carolinensis)
Reptilia RNF1516
ring finger protein 151
16(a)
1 ↔ 1
4(19017952-19033979)
tropical clawed frog
(Xenopus tropicalis)
Amphibia rnf1511 ring finger protein 151 60.52(n)
45.83(a)
  101733072  XM_004918061.1  XP_004918118.1 
zebrafish
(Danio rerio)
Actinopterygii LOC1000046741 RING finger protein 151-like 54.69(n)
45.51(a)
  100004674  XM_001343883.2  XP_001343919.2 
fruit fly
(Drosophila melanogaster)
Insecta CG90146
--
15(a)
1 ↔ 1
2L(13722170-13723642)


ENSEMBL Gene Tree for RNF151 (if available)
TreeFam Gene Tree for RNF151 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for RNF151 gene
RNF412  
5 SIMAP similar genes for RNF151 using alignment to 2 protein entries:     RN151_HUMAN (see all proteins):
RNF135    RNF138    TRIM39    TRIM59    RNF41

RNF151 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for RNF151 (see all 109)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 16 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs133322561,2
C,F,H--2016861(+) TGTGGA/GGCTGC 1 -- us2k17Minor allele frequency- G:0.01NS NA WA 964
rs1477068591,2
C--2016906(+) TCTTGC/ATTCCA 1 -- int12Minor allele frequency- A:0.00NS EU 719
rs3703018761,2
C--2016963(+) GGATCA/GACCCC 1 -- int10--------
rs726332621,2
C--2017071(+) CCCCCG/ATCTCC 1 -- int14Minor allele frequency- A:0.14WA NA EA 360
rs1172727931,2
F--2017114(+) CCTAAC/TCCCCA 1 -- int11Minor allele frequency- T:0.03NA 120
rs752356861,2
C,F--2017142(+) TGGGCG/ACTGAG 1 -- int11Minor allele frequency- A:0.03WA 118
rs1143146591,2
C,F--2017157(+) CCCCTT/CTACTT 1 -- int11Minor allele frequency- C:0.11WA 118
rs1391870141,2
C--2017335(+) GCTCCA/GTCTGC 2 I V mis10--------
rs2000222721,2
C,F--2017428(+) GCCAGC/TGGGTA 1 -- int11Minor allele frequency- T:0.01EU 561
rs3708402551,2
C--2017461(+) AGTGAA/GACTGG 1 -- int10--------

HapMap Linkage Disequilibrium report for RNF151 (2016824 - 2018976 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for RNF151 (see all 19):    About this table    
Variant IDTypeSubtypePubMed ID
esv2422427CNV Duplication17116639
dgv336n27CNV Loss19166990
dgv2545n71CNV Loss21882294
dgv2546n71CNV Loss21882294
nsv905048CNV Loss21882294
dgv2551n71CNV Loss21882294
dgv2540n71CNV Loss21882294
nsv905061CNV Loss21882294
dgv2553n71CNV Loss21882294
dgv2547n71CNV Loss21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for RNF151 gene integrated from 10 sources:
(articles sorted by number of sources associating them with RNF151)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  3. Mining and characterization of ubiquitin E3 ligases expressed in the mouse testis. (PubMed id 22992278)1 Hou X....Han C. (BMC Genomics 2012)
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 146310 HGNC: 23235 AceView: RNF151 Ensembl:ENSG00000179580 euGenes: HUgn146310
ECgene: RNF151 H-InvDB: RNF151

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for RNF151 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for RNF151 gene:
Search GeneIP for patents involving RNF151

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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