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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RNF151 Gene

protein-coding   GIFtS: 38
GCID: GC16P002092

Ring Finger Protein 151

  Search for RNF151
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ring Finger Protein 1511 2

External Ids:    HGNC: 232351   Entrez Gene: 1463102   Ensembl: ENSG000001795807   UniProtKB: Q2KHN13   

Export aliases for RNF151 gene to outside databases

Previous GC identifers: GC16P001957 GC16P001958 GC16P001959 GC16P001963 GC16P002017 GC16P002019 GC16P001940 GC16P002024 GC16P002028 GC16P002047 GC16P002054 GC16P002077


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RNF151 Gene: 
RNF151 (ring finger protein 151) is a protein-coding gene. GO annotations related to this gene include ubiquitin-protein ligase activity and zinc ion binding. An important paralog of this gene is RNF41.

UniProtKB/Swiss-Prot: RN151_HUMAN, Q2KHN1
Function: May be involved in acrosome formation of spermatids




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010393.16  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RNF151 gene promoter:
         SRF   NF-1/L   NF-1   MAZR   Pax-5   SRF (504 AA)   AP-4   NF-kappaB1   c-Ets-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for RNF151

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF151


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

RNF151 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF151 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P002092:  view genomic region     (about GC identifiers)

Start:
2,016,824 bp from pter      End:
2,018,976 bp from pter
Size:
2,153 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RN151_HUMAN, Q2KHN1 (See protein sequence)
Recommended Name: RING finger protein 151  
Size: 245 amino acids; 27412 Da
Subunit: Interacts with DTNBP1 (By similarity)
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity)
Secondary accessions: Q8NHS5

Explore the universe of human proteins at neXtProt for RNF151: NX_Q2KHN1

Explore proteomics data for RNF151 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q2KHN1

  • RNF151 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RNF151 Protein Expression
    REFSEQ proteins: NP_777563.2  
    ENSEMBL proteins: 
     ENSP00000454886   ENSP00000456566   ENSP00000325794  

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    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex ----
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    RNF151 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RNF: RING-type (C3HC4) zinc fingers

    5/7 InterPro protein domains (see all 7):
     IPR008974 TRAF-like
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR001293 Znf_TRAF
     IPR013010 Znf_SIAH

    Graphical View of Domain Structure for InterPro Entry Q2KHN1

    ProtoNet protein and cluster: Q2KHN1

    UniProtKB/Swiss-Prot: RN151_HUMAN, Q2KHN1
    Similarity: Contains 1 RING-type zinc finger
    Similarity: Contains 1 TRAF-type zinc finger


    RNF151 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RN151_HUMAN, Q2KHN1
    Function: May be involved in acrosome formation of spermatids

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IEA--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0046872metal ion binding ----
         
    RNF151 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RNF151:
     Decreased viability with pacli 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNF151

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007283spermatogenesis IEA--
    GO:0016567protein ubiquitination ----
    GO:0030154cell differentiation IEA--

    RNF151 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RNF151 (RN151)

    Search CenterWatch for drugs/clinical trials and news about RNF151 / RN151

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RNF151 gene: 
    NM_174903.4  

    Unigene Cluster for RNF151:

    Ring finger protein 151
    Hs.99354  [show with all ESTs]
    Unigene Representative Sequence: BI461348
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000569210 ENST00000569714(uc002cnt.1) ENST00000321392
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    Additional mRNA sequence: 

    BC029501.2 BC113014.2 

    2 DOTS entries:

    DT.70105132  DT.120656710 

    13 AceView cDNA sequences:

    BI829513 BE552345 AW236968 BC029501 AI653299 BX089545 BI461348 AI798656 
    AI351074 AA453999 BF057221 AJ457801 AI916892 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RNF151 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCCCTGGCC
    RNF151 Expression
    About this image


    See RNF151 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RNF151

    SOURCE GeneReport for Unigene cluster: Hs.99354
        SABiosciences Custom PCR Arrays for RNF151
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF151

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RNF151 gene from 5/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnf1511 , 5 ring finger protein 1511, 5 77.83(n)1
    71.3(a)1
      17 (12.51 cM)5
    675041  NM_026205.31  NP_080481.11 
     247158395 
    chicken
    (Gallus gallus)
    Aves RNF1516
    ring finger protein 151
    23(a)
    1 ↔ 1
    2(125907865-125917414)
    lizard
    (Anolis carolinensis)
    Reptilia RNF1516
    ring finger protein 151
    16(a)
    1 ↔ 1
    4(19017952-19033979)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000046741 RING finger protein 151-like 50.41(n)
    39.51(a)
      100004674  XM_001343883.1  XP_001343919.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG90146
    --
    14(a)
    1 ↔ 1
    2L(13722170-13723642)


    ENSEMBL Gene Tree for RNF151 (if available)
    TreeFam Gene Tree for RNF151 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RNF151 gene
    RNF412  
    5 SIMAP similar genes for RNF151 using alignment to 2 protein entries:     RN151_HUMAN (see all proteins):
    RNF135    RNF138    TRIM39    TRIM59    RNF41

    RNF151 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/109 SNPs in RNF151 are shown (see all 109)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs133322561,2
    C,F,H--2016861(+) TGTGGA/GGCTGC 1 -- us2k17Minor allele frequency- G:0.01NS NA WA 964
    rs1477068591,2
    C--2016906(+) TCTTGC/ATTCCA 1 -- int12Minor allele frequency- A:0.00NS EU 719
    rs3703018761,2
    C--2016963(+) GGATCA/GACCCC 1 -- int10--------
    rs726332621,2
    C--2017071(+) CCCCCG/ATCTCC 1 -- int14Minor allele frequency- A:0.14WA NA EA 360
    rs1172727931,2
    F--2017114(+) CCTAAC/TCCCCA 1 -- int11Minor allele frequency- T:0.03NA 120
    rs752356861,2
    C,F--2017142(+) TGGGCG/ACTGAG 1 -- int11Minor allele frequency- A:0.03WA 118
    rs1143146591,2
    C,F--2017157(+) CCCCTT/CTACTT 1 -- int11Minor allele frequency- C:0.11WA 118
    rs1391870141,2
    C--2017335(+) GCTCCA/GTCTGC 2 I V mis10--------
    rs2000222721,2
    C,F--2017428(+) GCCAGC/TGGGTA 1 -- int11Minor allele frequency- T:0.01EU 561
    rs3708402551,2
    C--2017461(+) AGTGAA/GACTGG 1 -- int10--------

    HapMap Linkage Disequilibrium report for RNF151 (2016824 - 2018976 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/19 variations for RNF151 (see all 19):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2422427CNV Duplication17116639
    dgv336n27CNV Loss19166990
    dgv2545n71CNV Loss21882294
    dgv2546n71CNV Loss21882294
    nsv905048CNV Loss21882294
    dgv2551n71CNV Loss21882294
    dgv2540n71CNV Loss21882294
    nsv905061CNV Loss21882294
    dgv2553n71CNV Loss21882294
    dgv2547n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RNF151 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with RNF151)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    3. Mining and characterization of ubiquitin E3 ligases ex pressed in the mouse testis. (PubMed id 22992278)1 Hou X....Han C. (2012)
    4. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 146310 HGNC: 23235 AceView: RNF151 Ensembl:ENSG00000179580 euGenes: HUgn146310
    ECgene: RNF151 H-InvDB: RNF151

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RNF151 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RNF151 gene:
    Search GeneIP for patents involving RNF151

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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