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Aliases for RNF150 Gene

Aliases for RNF150 Gene

  • Ring Finger Protein 150 2 3 5
  • KIAA1214 4

External Ids for RNF150 Gene

Previous GeneCards Identifiers for RNF150 Gene

  • GC04M142367
  • GC04M142364
  • GC04M142144
  • GC04M142006
  • GC04M141786
  • GC04M137516

Summaries for RNF150 Gene

GeneCards Summary for RNF150 Gene

RNF150 (Ring Finger Protein 150) is a Protein Coding gene. An important paralog of this gene is RNF130.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF150 Gene

Genomics for RNF150 Gene

Regulatory Elements for RNF150 Gene

Enhancers for RNF150 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F140236 1.1 Ensembl ENCODE 10.3 +974.4 974377 4.2 SIN3A FEZF1 RAD21 YY1 GLIS2 GATA2 EGR2 ZNF362 ZNF654 REST MAML3 RNF150 SCOC
GH04F141045 0.7 ENCODE 4.1 +166.3 166251 1.6 BHLHE40 SIN3A TBX21 RAD21 ATF2 JUND BCL6 FOS MAFK NFE2L2 RNF150 GC04P141077 GC04P140945
GH04F141027 0.6 ENCODE 4.7 +184.5 184457 1.2 OSR2 JUND ZNF366 ZNF501 FEZF1 TSHZ1 ZEB2 ZNF843 RNF150 GC04P141077 GC04P140945
GH04F141105 0.3 FANTOM5 2.7 +107.7 107673 0.1 RNF150 GC04M141077 GC04P141205
GH04F140880 0.3 FANTOM5 2.5 +332.3 332320 0.1 RNF150 GC04P140867 GC04P140911
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RNF150 on UCSC Golden Path with GeneCards custom track

Genomic Location for RNF150 Gene

Chromosome:
4
Start:
140,859,807 bp from pter
End:
141,212,877 bp from pter
Size:
353,071 bases
Orientation:
Minus strand

Genomic View for RNF150 Gene

Genes around RNF150 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF150 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF150 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF150 Gene

Proteins for RNF150 Gene

  • Protein details for RNF150 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULK6-RN150_HUMAN
    Recommended name:
    RING finger protein 150
    Protein Accession:
    Q9ULK6
    Secondary Accessions:
    • Q3T1D0
    • Q6ZNW6

    Protein attributes for RNF150 Gene

    Size:
    438 amino acids
    Molecular mass:
    48072 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA86528.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RNF150 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNF150 Gene

Post-translational modifications for RNF150 Gene

  • Glycosylation at Asn 45, Asn 125, Asn 153, and Asn 186
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RNF150 Gene

Domains & Families for RNF150 Gene

Gene Families for RNF150 Gene

Protein Domains for RNF150 Gene

Suggested Antigen Peptide Sequences for RNF150 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9ULK6

UniProtKB/Swiss-Prot:

RN150_HUMAN :
  • Contains 1 PA (protease associated) domain.
  • Contains 1 RING-type zinc finger.
Domain:
  • Contains 1 PA (protease associated) domain.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF150: view

Function for RNF150 Gene

Gene Ontology (GO) - Molecular Function for RNF150 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RNF150: view
genes like me logo Genes that share phenotypes with RNF150: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNF150 Gene

Localization for RNF150 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF150 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNF150 gene
Compartment Confidence
plasma membrane 3
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for RNF150 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RNF150: view

Pathways & Interactions for RNF150 Gene

SuperPathways for RNF150 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RNF150 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RNF150 Gene

Transcripts for RNF150 Gene

Unigene Clusters for RNF150 Gene

Ring finger protein 150:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF150 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1: - -
SP2:

Relevant External Links for RNF150 Gene

GeneLoc Exon Structure for
RNF150
ECgene alternative splicing isoforms for
RNF150

Expression for RNF150 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RNF150 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNF150 Gene

This gene is overexpressed in Heart - Left Ventricle (x4.3).

Protein differential expression in normal tissues from HIPED for RNF150 Gene

This gene is overexpressed in Ovary (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RNF150 Gene



Protein tissue co-expression partners for RNF150 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RNF150 Gene:

RNF150

SOURCE GeneReport for Unigene cluster for RNF150 Gene:

Hs.659104
genes like me logo Genes that share expression patterns with RNF150: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for RNF150 Gene

Orthologs for RNF150 Gene

This gene was present in the common ancestor of animals.

Orthologs for RNF150 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNF150 34 35
  • 99.54 (n)
oppossum
(Monodelphis domestica)
Mammalia RNF150 35
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNF150 35
  • 92 (a)
OneToOne
LOC607611 34
  • 88.66 (n)
mouse
(Mus musculus)
Mammalia Rnf150 34 16 35
  • 91 (n)
rat
(Rattus norvegicus)
Mammalia Rnf150 34
  • 90.47 (n)
cow
(Bos Taurus)
Mammalia RNF150 34
  • 90.33 (n)
chicken
(Gallus gallus)
Aves RNF150 34 35
  • 80.43 (n)
lizard
(Anolis carolinensis)
Reptilia RNF150 35
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf150 34
  • 77.54 (n)
zebrafish
(Danio rerio)
Actinopterygii rnf150a 35
  • 71 (a)
OneToMany
rnf150b 35
  • 70 (a)
OneToMany
LOC559804 34
  • 69.87 (n)
worm
(Caenorhabditis elegans)
Secernentea H10E21.5 35
  • 26 (a)
OneToMany
Species where no ortholog for RNF150 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RNF150 Gene

ENSEMBL:
Gene Tree for RNF150 (if available)
TreeFam:
Gene Tree for RNF150 (if available)

Paralogs for RNF150 Gene

(8) SIMAP similar genes for RNF150 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RNF150: view

Variants for RNF150 Gene

Sequence variations from dbSNP and Humsavar for RNF150 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10000204 -- 141,036,812(+) ATATT(A/T)AAAAA intron-variant
rs10001083 -- 141,128,254(+) TAAAC(A/G)CTGTA intron-variant
rs10001746 -- 141,027,735(+) GCCTA(C/T)ATAAG intron-variant
rs10002095 -- 140,903,126(+) TAACA(A/G)AAATG intron-variant
rs10002722 -- 140,867,497(+) AGAGC(G/T)CCCTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RNF150 Gene

Variant ID Type Subtype PubMed ID
esv1188340 CNV insertion 17803354
esv1974835 CNV deletion 18987734
esv2511191 CNV deletion 19546169
esv2672621 CNV deletion 23128226
esv2728441 CNV deletion 23290073
esv2728442 CNV deletion 23290073
esv275310 CNV gain+loss 21479260
esv3348654 CNV insertion 20981092
esv3564728 CNV deletion 23714750
esv3602457 CNV loss 21293372
esv3602458 CNV loss 21293372
nsv1152215 CNV deletion 26484159
nsv4530 CNV insertion 18451855
nsv509936 OTHER sequence alteration 20534489
nsv526770 CNV loss 19592680
nsv527493 CNV loss 19592680
nsv830090 CNV gain 17160897
nsv830091 CNV loss 17160897

Variation tolerance for RNF150 Gene

Residual Variation Intolerance Score: 45.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.58; 56.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNF150 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNF150

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF150 Gene

Disorders for RNF150 Gene

Relevant External Links for RNF150

Genetic Association Database (GAD)
RNF150
Human Genome Epidemiology (HuGE) Navigator
RNF150
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RNF150

No disorders were found for RNF150 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF150 Gene

Publications for RNF150 Gene

  1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for RNF150 Gene

Sources for RNF150 Gene

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