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RNF149 Gene

protein-coding   GIFtS: 51
GCID: GC02M101887

Ring Finger Protein 149

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ring Finger Protein 1491 2 3
DNAPTP22 3
DNA Polymerase-Transactivated Protein 22 3
E3 Ubiquitin-Protein Ligase RNF1492
EC 6.3.2.-3

External Ids:    HGNC: 231371   Entrez Gene: 2849962   Ensembl: ENSG000001631627   UniProtKB: Q8NC423   

Export aliases for RNF149 gene to outside databases

Previous GC identifers: GC02M101513 GC02M101351 GC02M101258 GC02M095656


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RNF149 Gene:
RNF149 (ring finger protein 149) is a protein-coding gene. Diseases associated with RNF149 include labyrinthitis, and breast and colorectal cancer. GO annotations related to this gene include ligase activity. An important paralog of this gene is ZNRF3.

UniProtKB/Swiss-Prot: RN149_HUMAN, Q8NC42
Function: E3 ubiquitin-protein ligase. Ubiquitinates BRAF, inducing its proteasomal degradation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RNF149 gene promoter:
         RFX1   HTF   AP-4   LCR-F1   POU3F2   HEN1   CP2   POU2F1   POU2F1a   Cart-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNF149 promoter sequence
   Search Chromatin IP Primers for RNF149

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNF149


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q11.2   Ensembl cytogenetic band:  2q11.2   HGNC cytogenetic band: 2q12.1

RNF149 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF149 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M101887:  view genomic region     (about GC identifiers)

Start:
101,887,681 bp from pter      End:
101,925,178 bp from pter
Size:
37,498 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RN149_HUMAN, Q8NC42 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase RNF149 precursor  
Size: 400 amino acids; 43165 Da
Secondary accessions: Q53S14 Q8N5I8 Q8NBY5 Q8WUU3

Explore the universe of human proteins at neXtProt for RNF149: NX_Q8NC42

Explore proteomics data for RNF149 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys245, Lys260
  • Glycosylation2 at Asn52, Asn145
  • Modification sites at PhosphoSitePlus

  • See RNF149 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_775918.2  
    ENSEMBL proteins: 
     ENSP00000399090   ENSP00000295317  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers

    3 InterPro protein domains:
     IPR001841 Znf_RING
     IPR003137 Protease-assoc_domain
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q8NC42

    ProtoNet protein and cluster: Q8NC42

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: RN149_HUMAN, Q8NC42
    Domain: The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme (By similarity)
    Similarity: Contains 1 PA (protease associated) domain
    Similarity: Contains 1 RING-type zinc finger


    RNF149 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RN149_HUMAN, Q8NC42
    Function: E3 ubiquitin-protein ligase. Ubiquitinates BRAF, inducing its proteasomal degradation

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0016874ligase activity IEA--
    GO:0046872metal ion binding ----
         
    RNF149 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RNF149:
     Decreased Salmonella enterica  

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RNF149
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    miRTarBase miRNAs that target RNF149:
    hsa-mir-373-3p (MIRT002520), hsa-mir-15b-5p (MIRT046533), hsa-mir-186-5p (MIRT045180), hsa-mir-615-3p (MIRT039925), hsa-mir-16-5p (MIRT031790)

    Block miRNA regulation of human, mouse, rat RNF149 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RNF149 (see all 18):
    hsa-miR-3149 hsa-miR-498 hsa-miR-607 hsa-miR-300 hsa-miR-24-1* hsa-miR-24-2* hsa-miR-155 hsa-miR-3662
    SwitchGear 3'UTR luciferase reporter plasmidRNF149 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF149


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RN149_HUMAN, Q8NC42: Membrane; Single-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane2
    endoplasmic reticulum1
    extracellular1
    golgi apparatus1
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    RNF149 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    UniProtKB/Swiss-Prot: RN149_HUMAN, Q8NC42
    Pathway: Protein modification; protein ubiquitination

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RNF149
    Interactions:

        Search GeneGlobe Interaction Network for RNF149

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    Selected Interacting proteins for RNF149 (Q8NC422 ENSP000002953174) via UniProtKB, MINT, STRING, and/or I2D (see all 67)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCP0CG482, ENSP000003448184MINT-6489355 STRING: ENSP00000344818
    AGO2Q9UKV82, ENSP000002205924MINT-6489355 STRING: ENSP00000220592
    ATP5C1P365422MINT-6489355
    CMSS1Q9BQ752MINT-6489355
    COPAP536212MINT-6489355
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016567protein ubiquitination IEA--

    RNF149 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RNF149 (RN149)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RNF149 gene: 
    NM_173647.3  

    Unigene Cluster for RNF149:

    Ring finger protein 149
    Hs.142074  [show with all ESTs]
    Unigene Representative Sequence: NM_173647
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000485752 ENST00000424632(uc002tax.2) ENST00000295317(uc002taz.2)
    ENST00000490553 ENST00000463726 ENST00000478404
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate RNF149 (see all 18):
    hsa-miR-3149 hsa-miR-498 hsa-miR-607 hsa-miR-300 hsa-miR-24-1* hsa-miR-24-2* hsa-miR-155 hsa-miR-3662
    SwitchGear 3'UTR luciferase reporter plasmidRNF149 3' UTR sequence
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    Predesigned siRNA for gene silencing in human, mouse, rat RNF149
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    Primer
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    OriGene qPCR primer pairs and template standards for RNF149
    OriGene qSTAR qPCR primer pairs in human, mouse for RNF149
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RNF149
      QuantiTect SYBR Green Assays in human, mouse, rat RNF149
      QuantiFast Probe-based Assays in human, mouse, rat RNF149

    Additional mRNA sequence: 

    AK074985.1 AK075141.1 AK123500.1 AY450390.1 BC019355.1 BC032328.1 BC045743.1 

    15 DOTS entries:

    DT.414998  DT.408425  DT.97763360  DT.40221131  DT.414999  DT.439071  DT.86852548  DT.91654828 
    DT.102828241  DT.100811730  DT.100027144  DT.100720195  DT.95374775  DT.100837766  DT.120942375 

    Selected AceView cDNA sequences (see all 292):

    AI914592 BU622116 CR624747 AA320132 BU633501 BU686056 CA430329 AW161820 
    T40905 CB158321 R41271 AI564061 BM978724 AA989416 AI143497 AK129799 
    BC019355 T39949 BE646330 CA441783 NM_173647 CR591001 BQ006574 CF529478 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RNF149 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCTTTCCCT
    RNF149 Expression
    About this image


    RNF149 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Stem Bronchi
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Thymus (Hematopoietic System)
             Thymus
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Kidney (Urinary System)
             Metanephros
    RNF149 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RNF149 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.142074
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF149

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RNF149 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnf1491 , 5 ring finger protein 1491, 5 81.04(n)1
    77.3(a)1
      1 (18.33 cM)5
    677021  NM_001033135.31  NP_001028307.21 
     395512965 
    chicken
    (Gallus gallus)
    Aves RNF1491 ring finger protein 149 76(n)
    73.2(a)
      418712  XM_416911.4  XP_416911.4 
    lizard
    (Anolis carolinensis)
    Reptilia RNF1496
    ring finger protein 149
    61(a)
    1 ↔ 1
    GL343542.1(107344-120200)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia rnf1491 ring finger protein 149 66.39(n)
    63.36(a)
      780151  NM_001079226.1  NP_001072694.1 
    worm
    (Caenorhabditis elegans)
    Secernentea H10E21.56
    Protein H10E21.5 (H10E21.5) mRNA, complete cds
    21(a)
    1 → many
    III(20527-23962) WBGene00019185


    ENSEMBL Gene Tree for RNF149 (if available)
    TreeFam Gene Tree for RNF149 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RNF149 gene
    ZNRF32  RNF432  RNF1482  RNF1332  RNF1502  RNF1302  RNF1672  RNF2152  
    RNF1282  ZNRF42  RNF132  
    7 SIMAP similar genes for RNF149 using alignment to 2 protein entries:     RN149_HUMAN (see all proteins):
    LOC284996    RNF150    RNF128    RNF148    RNF130    RNF133
    RNF24

    RNF149 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RNF149 (see all 605)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0359584
    A breast cancer sample4--see VAR_0359582 E K mis40--------
    rs1864309201,2
    C--101893683(+) GCCACA/TTCAGT 1 -- ut310--------
    rs1911573691,2
    C--101893691(+) AGTGGA/GCACGT 1 -- ut310--------
    rs1399362891,2
    F--101893722(+) CATGCC/TGAGAG 2 Q R mis11Minor allele frequency- T:0.00NA 4546
    rs2011097511,2
    --101893767(+) AGCTAC/GTCCAT 1 -- int10--------
    rs2003538931,2
    --101893783(+) GAGGGC/GAGCAT 1 -- int10--------
    rs1827813801,2
    --101893861(+) AAAAAA/TTTTTT 1 -- int10--------
    rs346327831,2
    C--101893967(+) TGCCT-/CAGCCT 1 -- int11Minor allele frequency- C:0.00NA 2
    rs75872021,2
    C--101894142(+) caccgC/Tgcccg 1 -- int10--------
    rs1876549791,2
    --101894143(+) ACCGCA/GCCCGG 1 -- int10--------

    HapMap Linkage Disequilibrium report for RNF149 (101887681 - 101925178 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for RNF149:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv34123CNV Loss18971310

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RNF149
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    6 diseases for RNF149:    
    About MalaCards
    labyrinthitis    breast and colorectal cancer    pancreatic cancer    pancreatitis
    colorectal cancer    cerebritis


    RNF149 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RNF149

    Export disorders for RNF149 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RNF149 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with RNF149)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. RING finger protein 149 is an E3 ubiquitin ligase active on wild-type BRAF. (PubMed id 22628551)1, 2 Hong S.W.... Kim T.W. (J. Biol. Chem. 2012)
    2. Genome-wide association study of pancreatic cancer in Japanese population. (PubMed id 20686608)1, 4 Low S.K....Sakamoto H. (PLoS ONE 2010)
    3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (J. Biol. Chem. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 284996 HGNC: 23137 AceView: RNF149 Ensembl:ENSG00000163162 euGenes: HUgn284996
    ECgene: RNF149 H-InvDB: RNF149

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RNF149 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RNF149 gene:
    Search GeneIP for patents involving RNF149

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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