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Aliases for RNF149 Gene

Aliases for RNF149 Gene

  • Ring Finger Protein 149 2 3
  • DNA Polymerase-Transactivated Protein 2 3 4
  • DNAPTP2 3 4
  • E3 Ubiquitin-Protein Ligase RNF149 3
  • RING Finger Protein 149 4
  • EC 6.3.2.- 4

External Ids for RNF149 Gene

Summaries for RNF149 Gene

GeneCards Summary for RNF149 Gene

RNF149 (Ring Finger Protein 149) is a Protein Coding gene. GO annotations related to this gene include ligase activity. An important paralog of this gene is RNF167.

UniProtKB/Swiss-Prot for RNF149 Gene

  • E3 ubiquitin-protein ligase. Ubiquitinates BRAF, inducing its proteasomal degradation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF149 Gene

Genomics for RNF149 Gene

Genomic Location for RNF149 Gene

Start:
101,271,219 bp from pter
End:
101,308,716 bp from pter
Size:
37,498 bases
Orientation:
Minus strand

Genomic View for RNF149 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNF149 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF149 Gene

Regulatory Elements for RNF149 Gene

Proteins for RNF149 Gene

  • Protein details for RNF149 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NC42-RN149_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase RNF149
    Protein Accession:
    Q8NC42
    Secondary Accessions:
    • Q53S14
    • Q8N5I8
    • Q8NBY5
    • Q8WUU3

    Protein attributes for RNF149 Gene

    Size:
    400 amino acids
    Molecular mass:
    43165 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RNF149 Gene

Proteomics data for RNF149 Gene at MOPED

Post-translational modifications for RNF149 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys245 and Lys260
  • Glycosylation at Asn52 and Asn145

Other Protein References for RNF149 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RNF149 Gene

Domains for RNF149 Gene

Gene Families for RNF149 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for RNF149 Gene

Suggested Antigen Peptide Sequences for RNF149 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NC42

UniProtKB/Swiss-Prot:

RN149_HUMAN
Domain:
  • The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme.:
    • Q8NC42
  • Contains 1 PA (protease associated) domain.:
    • Q8NC42
Similarity:
  • Contains 1 RING-type zinc finger.:
    • Q8NC42
genes like me logo Genes that share domains with RNF149: view

Function for RNF149 Gene

Molecular function for RNF149 Gene

UniProtKB/Swiss-Prot Function: E3 ubiquitin-protein ligase. Ubiquitinates BRAF, inducing its proteasomal degradation.

Enzyme Numbers (IUBMB) for RNF149 Gene

Gene Ontology (GO) - Molecular Function for RNF149 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IEA --
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with RNF149: view

Phenotypes for RNF149 Gene

GenomeRNAi human phenotypes for RNF149:
genes like me logo Genes that share phenotypes with RNF149: view

miRNA for RNF149 Gene

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for RNF149 Gene

Localization for RNF149 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF149 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNF149 Gene COMPARTMENTS Subcellular localization image for RNF149 gene
Compartment Confidence
plasma membrane 2
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RNF149 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with RNF149: view

Pathways for RNF149 Gene

SuperPathways for RNF149 Gene

No Data Available

UniProtKB/Swiss-Prot Q8NC42-RN149_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for RNF149 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0031647 regulation of protein stability IEA --
GO:0035690 cellular response to drug IEA --
GO:0043409 negative regulation of MAPK cascade IEA --
genes like me logo Genes that share ontologies with RNF149: view

No data available for Pathways by source for RNF149 Gene

Transcripts for RNF149 Gene

Unigene Clusters for RNF149 Gene

Ring finger protein 149:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNF149 Gene

No ASD Table

Relevant External Links for RNF149 Gene

GeneLoc Exon Structure for
RNF149
ECgene alternative splicing isoforms for
RNF149

Expression for RNF149 Gene

mRNA expression in normal human tissues for RNF149 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNF149 Gene

This gene is overexpressed in Whole Blood (17.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RNF149 Gene

SOURCE GeneReport for Unigene cluster for RNF149 Gene Hs.142074

genes like me logo Genes that share expressions with RNF149: view

No data available for mRNA Expression by UniProt/SwissProt for RNF149 Gene

Orthologs for RNF149 Gene

This gene was present in the common ancestor of animals.

Orthologs for RNF149 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNF149 35
  • 99.25 (n)
  • 99 (a)
RNF149 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RNF149 35
  • 84.31 (n)
  • 81.07 (a)
RNF149 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNF149 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnf149 35
  • 81.04 (n)
  • 77.3 (a)
Rnf149 16
Rnf149 36
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RNF149 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RNF149 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnf149 35
  • 81.55 (n)
  • 77.3 (a)
chicken
(Gallus gallus)
Aves RNF149 35
  • 76 (n)
  • 73.2 (a)
RNF149 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RNF149 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf149 35
  • 66.39 (n)
  • 63.36 (a)
worm
(Caenorhabditis elegans)
Secernentea H10E21.5 36
  • 21 (a)
OneToMany
Species with no ortholog for RNF149:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for RNF149 Gene

ENSEMBL:
Gene Tree for RNF149 (if available)
TreeFam:
Gene Tree for RNF149 (if available)

Paralogs for RNF149 Gene

Selected SIMAP similar genes for RNF149 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RNF149: view

Variants for RNF149 Gene

Sequence variations from dbSNP and Humsavar for RNF149 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs13151 - 101,281,950(+) CTGCT(C/G)TCATC reference, missense, nc-transcript-variant
rs935065 -- 101,282,668(+) GAAAC(C/T)TTATT intron-variant
rs1192792 -- 101,280,201(+) ATAAT(A/G)ATGAT intron-variant
rs1192793 -- 101,281,409(+) GGGGA(C/T)GACTA intron-variant, downstream-variant-500B
rs1192794 -- 101,281,760(+) CTCGA(A/G)CAATC intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for RNF149 Gene

Variant ID Type Subtype PubMed ID
esv34123 CNV Loss 18971310

Relevant External Links for RNF149 Gene

HapMap Linkage Disequilibrium report
RNF149

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF149 Gene

Disorders for RNF149 Gene

Relevant External Links for RNF149

Genetic Association Database (GAD)
RNF149
genes like me logo Genes that share disorders with RNF149: view

No data available for UniProtKB/Swiss-Prot for RNF149 Gene

Publications for RNF149 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  4. Genome-wide association study of pancreatic cancer in Japanese population. (PMID: 20686608) Low S.K. … Sakamoto H. (PLoS ONE 2010) 3 48
  5. RING finger protein 149 is an E3 ubiquitin ligase active on wild-type BRAF. (PMID: 22628551) Hong S.W. … Kim T.W. (J. Biol. Chem. 2012) 3 4

Products for RNF149 Gene

  • antibodies-online peptides for RNF149
  • antibodies-online antibodies for RNF149
  • antibodies-online kits for RNF149

Sources for RNF149 Gene

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