Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RNF149 Gene

protein-coding   GIFtS: 50
GCID: GC02M101887

Ring Finger Protein 149

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ring Finger Protein 1491 2 3
DNAPTP22 3
DNA Polymerase-Transactivated Protein 22 3
E3 Ubiquitin-Protein Ligase RNF1492
EC 6.3.2.-3

External Ids:    HGNC: 231371   Entrez Gene: 2849962   Ensembl: ENSG000001631627   UniProtKB: Q8NC423   

Export aliases for RNF149 gene to outside databases

Previous GC identifers: GC02M101513 GC02M101351 GC02M101258 GC02M095656


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RNF149 Gene: 
RNF149 (ring finger protein 149) is a protein-coding gene. Diseases associated with RNF149 include pancreatic cancer, and pancreatitis. GO annotations related to this gene include zinc ion binding and ligase activity. An important paralog of this gene is ZNRF3.

UniProtKB/Swiss-Prot: RN149_HUMAN, Q8NC42
Function: E3 ubiquitin-protein ligase. Ubiquitinates BRAF, inducing its proteasomal degradation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022171.15  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RNF149 gene promoter:
         RFX1   HTF   AP-4   LCR-F1   POU3F2   HEN1   CP2   POU2F1   POU2F1a   Cart-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNF149 promoter sequence
   Search SABiosciences Chromatin IP Primers for RNF149

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF149


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q11.2   Ensembl cytogenetic band:  2q11.2   HGNC cytogenetic band: 2q12.1

RNF149 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF149 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M101887:  view genomic region     (about GC identifiers)

Start:
101,887,681 bp from pter      End:
101,925,178 bp from pter
Size:
37,498 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RN149_HUMAN, Q8NC42 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase RNF149 precursor  
Size: 400 amino acids; 43165 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Secondary accessions: Q53S14 Q8N5I8 Q8NBY5 Q8WUU3

Explore the universe of human proteins at neXtProt for RNF149: NX_Q8NC42

Explore proteomics data for RNF149 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8NC42

  • RNF149 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RNF149 Protein Expression
    REFSEQ proteins: NP_775918.2  
    ENSEMBL proteins: 
     ENSP00000399090   ENSP00000295317  

    Human Recombinant Protein Products for RNF149: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for RNF149
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for RNF149
    GenScript Custom Purified and Recombinant Proteins Services for RNF149
    Novus Biologicals RNF149 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RNF149 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    RNF149 for ontologies           About GeneDecksing



    RNF149 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for RNF149
    GenScript Custom Superior Antibodies Services for RNF149
    Novus Biologicals RNF149 Antibodies
    Search for Antibodies for RNF149 at Abcam
    Cloud-Clone Corp. Antibodies for RNF149 
    Search ThermoFisher Antibodies for RNF149
    LSBio Antibodies in human, mouse, rat for RNF149 

    Assay Products for RNF149: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RNF149
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RNF149
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RNF149 
    Cloud-Clone Corp. CLIAs for RNF149


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RNF: RING-type (C3HC4) zinc fingers

    3 InterPro protein domains:
     IPR001841 Znf_RING
     IPR003137 Protease-assoc_domain
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q8NC42

    ProtoNet protein and cluster: Q8NC42

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: RN149_HUMAN, Q8NC42
    Domain: The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme (By similarity)
    Similarity: Contains 1 PA (protease associated) domain
    Similarity: Contains 1 RING-type zinc finger


    RNF149 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RN149_HUMAN, Q8NC42
    Function: E3 ubiquitin-protein ligase. Ubiquitinates BRAF, inducing its proteasomal degradation

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0016874ligase activity IEA--
    GO:0046872metal ion binding ----
         
    RNF149 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RNF149:
     Decreased Salmonella enterica  

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RNF149 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RNF149

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RNF149 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RNF149 

    miRNA
    Products:
        
    miRTarBase miRNAs that target RNF149:
    hsa-mir-373 (MIRT002520)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RNF149
    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate RNF149 (see all 18):
    hsa-miR-3149 hsa-miR-498 hsa-miR-607 hsa-miR-300 hsa-miR-24-1* hsa-miR-24-2* hsa-miR-155 hsa-miR-3662
    SwitchGear 3'UTR luciferase reporter plasmidRNF149 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RNF149
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNF149

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RNF149
    Sirion Biotech Customized adenovirus for overexpression of RNF149

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for RNF149 (see all 7)
    OriGene ORF clones in mouse, rat for RNF149
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RNF149 (NM_173647)
    Sino Biological Human cDNA Clone for RNF149
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNF149
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF149
    Sirion Biotech Customized lentivirus for stable overexpression of RNF149 
                         Customized lentivirus expression plasmids for stable overexpression of RNF149 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RNF149
    Search LifeMap BioReagents cell lines for RNF149
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF149


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    UniProtKB/Swiss-Prot: RN149_HUMAN, Q8NC42
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNF149

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/68 Interacting proteins for RNF149 (Q8NC422 ENSP000002953174) via UniProtKB, MINT, STRING, and/or I2D (see all 68)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCP0CG482, ENSP000003448184MINT-6489355 STRING: ENSP00000344818
    AGO2Q9UKV82, ENSP000002205924MINT-6489355 STRING: ENSP00000220592
    ATP5C1P365422MINT-6489355
    CMSS1Q9BQ752MINT-6489355
    COPAP536212MINT-6489355
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016567protein ubiquitination IEA--

    RNF149 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RNF149 (RN149)

    Search CenterWatch for drugs/clinical trials and news about RNF149 / RN149

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RNF149 gene: 
    NM_173647.3  

    Unigene Cluster for RNF149:

    Ring finger protein 149
    Hs.142074  [show with all ESTs]
    Unigene Representative Sequence: NM_173647
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000485752 ENST00000424632(uc002tax.2) ENST00000295317(uc002taz.2)
    ENST00000490553 ENST00000463726 ENST00000478404
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RNF149
    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate RNF149 (see all 18):
    hsa-miR-3149 hsa-miR-498 hsa-miR-607 hsa-miR-300 hsa-miR-24-1* hsa-miR-24-2* hsa-miR-155 hsa-miR-3662
    SwitchGear 3'UTR luciferase reporter plasmidRNF149 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RNF149
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNF149
    Clone
    Products:
         
    OriGene clones in human, mouse for RNF149 (see all 7)
    OriGene ORF clones in mouse, rat for RNF149
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RNF149 (NM_173647)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNF149
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF149
    Sirion Biotech Customized lentivirus for stable overexpression of RNF149 
                         Customized lentivirus expression plasmids for stable overexpression of RNF149 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RNF149
    OriGene qSTAR qPCR primer pairs in human, mouse for RNF149
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RNF149
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNF149
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNF149

    Additional mRNA sequence: 

    AK074985.1 AK075141.1 AK123500.1 AY450390.1 BC019355.1 BC032328.1 BC045743.1 

    15 DOTS entries:

    DT.414998  DT.408425  DT.97763360  DT.40221131  DT.414999  DT.439071  DT.86852548  DT.91654828 
    DT.102828241  DT.100811730  DT.100027144  DT.100720195  DT.95374775  DT.100837766  DT.120942375 

    24/292 AceView cDNA sequences (see all 292):

    BM311753 T40905 AI332435 BQ775527 AI564061 AK074985 BQ006574 BE891269 
    CF529478 CA430329 BU633501 BU686056 AI914592 NM_173647 BC019355 CR621578 
    BM978724 AA456638 BG740535 BF197913 AI143497 AW161820 BM979209 BU742514 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RNF149 expression in normal human tissues (normalized intensities)      RNF149 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCTTTCCCT
    RNF149 Expression
    About this image


    RNF149 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/26 selected tissues (see all 26) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
             ganglion/cranial   
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             heart/ventricle   
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Stem Bronchi
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon

    See RNF149 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RNF149

    SOURCE GeneReport for Unigene cluster: Hs.142074
        SABiosciences Custom PCR Arrays for RNF149
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RNF149
    OriGene qSTAR qPCR primer pairs in human, mouse for RNF149
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RNF149
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNF149
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNF149
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF149

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RNF149 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnf1491 , 5 ring finger protein 1491, 5 82.4(n)1
    79.08(a)1
      1 (18.33 cM)5
    677021  NM_001033135.31  NP_001028307.21 
     395512965 
    chicken
    (Gallus gallus)
    Aves RNF1491 ring finger protein 149 75.33(n)
    71.67(a)
      418712  XM_416911.3  XP_416911.3 
    lizard
    (Anolis carolinensis)
    Reptilia RNF1496
    Uncharacterized protein
    58(a)
    1 ↔ 1
    GL343542.1(107344-120200)
    fruit fly
    (Drosophila melanogaster)
    Insecta gol6
    goliath
    20(a)
    1 → many
    2R(20960150-20971843)
    worm
    (Caenorhabditis elegans)
    Secernentea H10E21.56
    Protein H10E21.5
    18(a)
    1 → many
    III(20527-23962)


    ENSEMBL Gene Tree for RNF149 (if available)
    TreeFam Gene Tree for RNF149 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RNF149 gene
    ZNRF32  RNF432  RNF1482  RNF1332  RNF1502  RNF1302  RNF1672  RNF2152  
    RNF1282  ZNRF42  RNF132  
    7 SIMAP similar genes for RNF149 using alignment to 2 protein entries:     RN149_HUMAN (see all proteins):
    LOC284996    RNF150    RNF128    RNF148    RNF130    RNF133
    RNF24

    RNF149 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/605 SNPs in RNF149 are shown (see all 605)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0359584
    A breast cancer sample4--see VAR_0359582 E K mis40--------
    VAR_0294554
    ----see VAR_0294552 S G mis40--------
    rs1864309201,2
    C--101893683(+) GCCACA/TTCAGT 1 -- ut310--------
    rs1911573691,2
    C--101893691(+) AGTGGA/GCACGT 1 -- ut310--------
    rs1399362891,2
    F--101893722(+) CATGCC/TGAGAG 2 Q R mis11Minor allele frequency- T:0.00NA 4546
    rs2011097511,2
    --101893767(+) AGCTAC/GTCCAT 1 -- int10--------
    rs2003538931,2
    --101893783(+) GAGGGC/GAGCAT 1 -- int10--------
    rs1827813801,2
    --101893861(+) AAAAAA/TTTTTT 1 -- int10--------
    rs346327831,2
    C--101893967(+) TGCCT-/CAGCCT 1 -- int11Minor allele frequency- C:0.00NA 2
    rs75872021,2
    C--101894142(+) caccgC/Tgcccg 1 -- int10--------

    HapMap Linkage Disequilibrium report for RNF149 (101887681 - 101925178 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for RNF149:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv34123CNV Loss18971310

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing RNF149
    DNA2.0 Custom Variant and Variant Library Synthesis for RNF149

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for RNF149:    About MalaCards
    pancreatic cancer    pancreatitis


    RNF149 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RNF149

    Export disorders for RNF149 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RNF149 gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with RNF149)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. RING finger protein 149 is an E3 ubiquitin ligase active on wild-type BRAF. (PubMed id 22628551)1, 2 Hong S.W.... Kim T.W. (2012)
    2. Genome-wide association study of pancreatic cancer in Japanese population. (PubMed id 20686608)1, 4 Low S.K....Sakamoto H. (2010)
    3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    7. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    8. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    9. Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 284996 HGNC: 23137 AceView: RNF149 Ensembl:ENSG00000163162 euGenes: HUgn284996
    ECgene: RNF149 H-InvDB: RNF149

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RNF149 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RNF149 gene:
    Search GeneIP for patents involving RNF149

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for RNF149  
     OriGene qPCR primer pairs and template standards for RNF149   OriGene Protein Over-expression Lysate for RNF149  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for RNF149  
     OriGene qSTAR qPCR primer pairs in human, mouse for RNF149   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for RNF149   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RNF149   OriGene Custom Protein Services for RNF149  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RNF149
     QIAGEN SeqTarget long-range PCR primers for resequencing RNF149
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF149
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNF149
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNF149
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNF149
     GenScript Custom Purified and Recombinant Proteins Services for RNF149 GenScript cDNA clones with any tag delivered in your preferred vector for RNF149
     GenScript Custom Assay Services for RNF149 GenScript Custom Superior Antibodies Services for RNF149
     GenScript Custom overexpressing Cell Line Services for RNF149 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in RNF149 promoter
     Search Chromatin IP Primers for RNF149
     RT2 qPCR Primer Assay in human, mouse, rat RNF149
     Search GNC Networks for RNF149
     SABiosciences Custom PCR Arrays for RNF149
     Search Tocris compounds for RNF149 (RN149)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for RNF149
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     RNF149 antibodies
     RNF149 lysates
     Search for Antibodies for RNF149 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for RNF149
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for RNF149
     Antibodies for RNF149
     ELISAs for RNF149
     CLIAs for RNF149
     Search LifeMap BioReagents cell lines for RNF149
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF149
     SwitchGear 3'UTR luciferase reporter plasmids for RNF149
     SwitchGear Promoter luciferase reporter plasmids for RNF149
     Search ThermoFisher Antibodies for RNF149
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF149
     inGenious Targeting Laboratory - Custom generated mouse model solutions for RNF149
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RNF149
    Customized:
     lentivirus for stable overexpression of RNF149
     lentivirus expression plasmids for stable overexpression of RNF149
     adenovirus for overexpression of RNF149
     LSBio Antibodies in human, mouse, rat for RNF149
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RNF149 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4