RNF148 Gene
protein-coding GIFtS: 38
GCID: GC07M122341
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|
ring finger protein 148
| |
Aliases
for RNF148 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ring Finger Protein 1481 2 | | MGC352221 |
Export aliases for RNF148 gene to outside databasesPrevious GC identifers: GC07U901252 GC07M121896 GC07M121935 GC07M122128 GC07M116705 |
Summaries
for RNF148 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for RNF148 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079596.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RNF148 gene promoter:
Max1 FOXF2 POU3F2 (N-Oct-5b) CUTL1 Nkx2-5 POU3F2 Tal-1beta E47 Nkx6-1 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for RNF148
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF148 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q31.33 Ensembl cytogenetic band: 7q31.32 HGNC cytogenetic band: 7q31.33RNF148 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M122341: view genomic region
(about GC identifiers)
Start:
|
122,341,718 bp from pter |
End:
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122,343,021 bp from pter |
Size:
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1,304 bases |
Orientation:
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minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 121,736,421-121,737,722 |
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Proteins
for RNF148 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RN148_HUMAN, Q8N7C7 (See
protein sequence)Recommended Name: RING finger protein 148 precursor Size: 305 amino acids; 34397 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Secondary accessions: Q8N308Explore the universe of human proteins at neXtProt for RNF148: NX_Q8N7C7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N7C7
RNF148 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_932351.1
ENSEMBL proteins: ENSP00000388207 ENSP00000412846
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
RNF148 for ontologies About GeneDecksing
RNF148 Antibody Products:
Assay Products for RNF148: |
Protein
Domains /
Families
for RNF148 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RNF148 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8N7C7ProtoNet protein and cluster: Q8N7C7 1 Blocks protein family: IPB001841 Zn-finger
UniProtKB/Swiss-Prot: RN148_HUMAN, Q8N7C7Similarity: Contains 1 PA (protease associated) domainSimilarity: Contains 1 RING-type zinc finger |
Function
for RNF148 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF148 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF148
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for RNF148 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF148 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF148 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008270 | zinc ion binding |
IEA | -- |
RNF148 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for RNF148:
|
Pathways & Interactions
for RNF148 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNF148
|
Drugs & Compounds
for RNF148 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RNF148
Search CenterWatch for drugs/clinical trials and news about RNF148 / RN148
|
Transcripts
for RNF148 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RNF148 gene: NM_198085.1 Unigene Cluster for RNF148: Ring finger protein 148 Hs.675191 [show with all ESTs]Unigene Representative Sequence: NM_1980852 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000434824(uc003vkk.1) ENST00000447240
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF148 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF148
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RNF148 (NM_198085) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RNF148 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF148 |
Additional cDNA sequence: AK058116.1 AK098654.1 BC029264.1 1 DOTS entry: DT.100016897 10 AceView cDNA sequences: AK058116 NM_198085 BC029264 AW779537 AK098654 BI831167 BU568896 BE044562 BE551919 BI830604
GeneLoc Exon Structure
|
Expression
for RNF148 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RNF148 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCCAGCAAAA
About this image
See RNF148 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RNF148
SOURCE GeneReport for Unigene cluster: Hs.675191
SABiosciences Expression via Pathway-Focused PCR Array including RNF148: | Ubiquitination (Ubiquitylation) Pathway in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNF148
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RNF148 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNF148 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNF148 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF148 |
Orthologs
for RNF148 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for RNF148 gene from 4/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
49(a) |
1 → many |
5(68088786-68089649) |
zebrafish
(Danio rerio) |
Actinopterygii |
rnf128a6si:dkeyp-86f7.46 |
si:dkeyp-86f7.4 |
33(a)32(a) |
many ↔ manymany ↔ many |
5(25346355-25365861) 14(9604773-9619261) |
fruit fly
(Drosophila melanogaster) |
Insecta |
gol6 |
goliath |
15(a) |
1 → many |
2R(20960150-20971843) |
worm
(Caenorhabditis elegans) |
Secernentea |
H10E21.56 |
Protein H10E21.5 |
12(a) |
1 → many |
III(20527-23962) |
ENSEMBL Gene Tree for RNF148 (if available)
TreeFam Gene Tree for RNF148 (if available) |
Paralogs
for RNF148 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RNF148 gene
- ZNRF32 RNF432 RNF1492 RNF1332 RNF1672 RNF1302 RNF1502 RNF2152
- RNF1282 ZNRF42 RNF132
5 SIMAP similar genes for RNF148 using alignment to 3 protein entries: RN148_HUMAN (see all proteins):RNF133 RNF128 RNF150 RNF149 RNF130
RNF148 for paralogs About GeneDecksing
|
Genomic Variants
for RNF148 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNF148 |
|
Disorders
/ Diseases
for RNF148 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for RNF148 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RNF148 gene integrated from 9 sources:
(articles sorted by number of sources associating them with RNF148) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Does this have a familiar RING? (PubMed id 8744354)1, 3 Saurin A.J....Freemont P.S. (1996)
- Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1 Scherer S.W.... Tsui L.-C. (2003)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for RNF148 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RNF148 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RNF148 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RNF148 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RNF148 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RNF148 gene:
Search GeneIP for patents involving RNF148
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RNF148 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RNF148 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RNF148 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNF148 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RNF148 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF148 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF148 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | | RNF148 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF148 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF148 |
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