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Aliases for RNF148 Gene

Aliases for RNF148 Gene

  • Ring Finger Protein 148 2 3

External Ids for RNF148 Gene

Summaries for RNF148 Gene

GeneCards Summary for RNF148 Gene

RNF148 (Ring Finger Protein 148) is a Protein Coding gene. An important paralog of this gene is RNF167.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF148 Gene

Genomics for RNF148 Gene

Genomic Location for RNF148 Gene

Start:
122,701,664 bp from pter
End:
122,702,967 bp from pter
Size:
1,304 bases
Orientation:
Minus strand

Genomic View for RNF148 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNF148 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF148 Gene

Regulatory Elements for RNF148 Gene

Proteins for RNF148 Gene

  • Protein details for RNF148 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N7C7-RN148_HUMAN
    Recommended name:
    RING finger protein 148
    Protein Accession:
    Q8N7C7
    Secondary Accessions:
    • A4D0X4
    • Q8N308

    Protein attributes for RNF148 Gene

    Size:
    305 amino acids
    Molecular mass:
    34397 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RNF148 Gene

Proteomics data for RNF148 Gene at MOPED

Post-translational modifications for RNF148 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn43

Other Protein References for RNF148 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RNF148 Gene

Domains for RNF148 Gene

Gene Families for RNF148 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for RNF148 Gene

UniProtKB/Swiss-Prot:

RN148_HUMAN
Domain:
  • Contains 1 PA (protease associated) domain.:
    • Q8N7C7
Similarity:
  • Contains 1 RING-type zinc finger.:
    • Q8N7C7
genes like me logo Genes that share domains with RNF148: view

Function for RNF148 Gene

Gene Ontology (GO) - Molecular Function for RNF148 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with RNF148: view

Phenotypes for RNF148 Gene

GenomeRNAi human phenotypes for RNF148:
genes like me logo Genes that share phenotypes with RNF148: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RNF148 Gene

Localization for RNF148 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF148 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNF148 Gene COMPARTMENTS Subcellular localization image for RNF148 gene
Compartment Confidence
mitochondrion 2
cytosol 1
extracellular 1
lysosome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RNF148 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RNF148: view

Pathways for RNF148 Gene

SuperPathways for RNF148 Gene

No Data Available

Interacting Proteins for RNF148 Gene

Gene Ontology (GO) - Biological Process for RNF148 Gene

None

No data available for Pathways by source for RNF148 Gene

Transcripts for RNF148 Gene

mRNA/cDNA for RNF148 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RNF148 Gene

Ring finger protein 148:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNF148 Gene

No ASD Table

Relevant External Links for RNF148 Gene

GeneLoc Exon Structure for
RNF148
ECgene alternative splicing isoforms for
RNF148

Expression for RNF148 Gene

mRNA expression in normal human tissues for RNF148 Gene

mRNA differential expression in normal tissues according to GTEx for RNF148 Gene

This gene is overexpressed in Testis (44.7).

SOURCE GeneReport for Unigene cluster for RNF148 Gene Hs.675191

mRNA Expression by UniProt/SwissProt for RNF148 Gene

Q8N7C7-RN148_HUMAN
Tissue specificity: Abundantly expressed in testis and slightly in pancreas. Mainly present in the interstitial cells of testicular tissues.
genes like me logo Genes that share expressions with RNF148: view

Orthologs for RNF148 Gene

This gene was present in the common ancestor of animals.

Orthologs for RNF148 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNF148 36
  • 99.02 (n)
  • 97.38 (a)
cow
(Bos Taurus)
Mammalia RNF148 36
  • 85.59 (n)
  • 82.18 (a)
dog
(Canis familiaris)
Mammalia RNF148 36
  • 88.11 (n)
  • 86.67 (a)
mouse
(Mus musculus)
Mammalia Rnf148 36
  • 83.11 (n)
  • 82.12 (a)
Rnf148 16
Rnf148 37
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RNF148 37
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnf148 36
  • 83.89 (n)
  • 84.9 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 33 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 30 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii rnf128a 37
  • 34 (a)
ManyToMany
si:dkeyp-86f7.4 37
  • 33 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea H10E21.5 37
  • 14 (a)
OneToMany
Species with no ortholog for RNF148:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RNF148 Gene

ENSEMBL:
Gene Tree for RNF148 (if available)
TreeFam:
Gene Tree for RNF148 (if available)

Paralogs for RNF148 Gene

Selected SIMAP similar genes for RNF148 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RNF148: view

Variants for RNF148 Gene

Sequence variations from dbSNP and Humsavar for RNF148 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
VAR_028855 -

Relevant External Links for RNF148 Gene

HapMap Linkage Disequilibrium report
RNF148

No data available for Structural Variations from Database of Genomic Variants (DGV) for RNF148 Gene

Disorders for RNF148 Gene

Relevant External Links for RNF148

Genetic Association Database (GAD)
RNF148
genes like me logo Genes that share disorders with RNF148: view

No data available for UniProtKB/Swiss-Prot for RNF148 Gene

Publications for RNF148 Gene

  1. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Identification of a novel human testicular interstitial gene, RNF148, and its expression regulated by histone deacetylases. (PMID: 24089095) Liu Y.Q. … Zhang S.Z. (Genet. Mol. Res. 2013) 3 4
  5. Does this have a familiar RING? (PMID: 8744354) Saurin A.J. … Freemont P.S. (Trends Biochem. Sci. 1996) 2 3

Products for RNF148 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Ubiquitination (Ubiquitylation) Pathway in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate RNF148
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for RNF148
    • Block miRNA regulation of RNF148 using miScript Target Protectors

    Sources for RNF148 Gene

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