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Aliases for RNF148 Gene

Aliases for RNF148 Gene

  • Ring Finger Protein 148 2 3 5

External Ids for RNF148 Gene

Previous GeneCards Identifiers for RNF148 Gene

  • GC07U901252
  • GC07M121896
  • GC07M121935
  • GC07M122128
  • GC07M122341
  • GC07M116705

Summaries for RNF148 Gene

GeneCards Summary for RNF148 Gene

RNF148 (Ring Finger Protein 148) is a Protein Coding gene. An important paralog of this gene is RNF133.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF148 Gene

Genomics for RNF148 Gene

Regulatory Elements for RNF148 Gene

Enhancers for RNF148 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F122677 0.9 ENCODE 11.5 +24.0 23981 2.6 ELF3 MLX ARID4B DMAP1 RAD21 RARA RCOR1 CREM MIXL1 HMG20B RNF133 RNF148 ENSG00000225795 RPS26P31
GH07F122633 0.6 FANTOM5 10.6 +69.4 69411 0.3 MTA2 SPI1 RNF133 RNF148 CADPS2 ENSG00000225795 LOC105375481
GH07F122678 0.5 ENCODE 11.4 +25.6 25606 0.1 CEBPA HNF4G EZH2 RNF133 RNF148 ENSG00000225795 RPS26P31
GH07F122674 0.4 ENCODE 11.7 +28.3 28276 0.3 SUZ12 RNF133 RNF148 ENSG00000225795 LOC105375481
GH07F122670 0.4 FANTOM5 11.5 +32.1 32093 0.0 EZH2 TAS2R16 RNF133 RNF148 ENSG00000225795 LOC105375481
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RNF148 on UCSC Golden Path with GeneCards custom track

Genomic Location for RNF148 Gene

Chromosome:
7
Start:
122,701,664 bp from pter
End:
122,702,967 bp from pter
Size:
1,304 bases
Orientation:
Minus strand

Genomic View for RNF148 Gene

Genes around RNF148 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF148 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF148 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF148 Gene

Proteins for RNF148 Gene

  • Protein details for RNF148 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N7C7-RN148_HUMAN
    Recommended name:
    RING finger protein 148
    Protein Accession:
    Q8N7C7
    Secondary Accessions:
    • A4D0X4
    • Q8N308

    Protein attributes for RNF148 Gene

    Size:
    305 amino acids
    Molecular mass:
    34397 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RNF148 Gene

Post-translational modifications for RNF148 Gene

  • Glycosylation at Asn 43
  • Modification sites at PhosphoSitePlus

Other Protein References for RNF148 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RNF148 Gene

Domains & Families for RNF148 Gene

Gene Families for RNF148 Gene

Protein Domains for RNF148 Gene

Suggested Antigen Peptide Sequences for RNF148 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N7C7

UniProtKB/Swiss-Prot:

RN148_HUMAN :
  • Contains 1 PA (protease associated) domain.
  • Contains 1 RING-type zinc finger.
Domain:
  • Contains 1 PA (protease associated) domain.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF148: view

Function for RNF148 Gene

Gene Ontology (GO) - Molecular Function for RNF148 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RNF148: view
genes like me logo Genes that share phenotypes with RNF148: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RNF148

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RNF148 Gene

Localization for RNF148 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF148 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNF148 gene
Compartment Confidence
mitochondrion 2
plasma membrane 1
extracellular 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for RNF148 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RNF148: view

Pathways & Interactions for RNF148 Gene

SuperPathways for RNF148 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RNF148 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RNF148 Gene

Transcripts for RNF148 Gene

mRNA/cDNA for RNF148 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RNF148 Gene

Ring finger protein 148:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF148 Gene

No ASD Table

Relevant External Links for RNF148 Gene

GeneLoc Exon Structure for
RNF148
ECgene alternative splicing isoforms for
RNF148

Expression for RNF148 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RNF148 Gene

mRNA differential expression in normal tissues according to GTEx for RNF148 Gene

This gene is overexpressed in Testis (x44.7).

NURSA nuclear receptor signaling pathways regulating expression of RNF148 Gene:

RNF148

SOURCE GeneReport for Unigene cluster for RNF148 Gene:

Hs.675191

mRNA Expression by UniProt/SwissProt for RNF148 Gene:

Q8N7C7-RN148_HUMAN
Tissue specificity: Abundantly expressed in testis and slightly in pancreas. Mainly present in the interstitial cells of testicular tissues.
genes like me logo Genes that share expression patterns with RNF148: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for RNF148 Gene

Orthologs for RNF148 Gene

This gene was present in the common ancestor of animals.

Orthologs for RNF148 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNF148 34
  • 99.02 (n)
dog
(Canis familiaris)
Mammalia RNF148 34
  • 88.11 (n)
cow
(Bos Taurus)
Mammalia RNF148 34
  • 85.59 (n)
rat
(Rattus norvegicus)
Mammalia Rnf148 34
  • 83.89 (n)
mouse
(Mus musculus)
Mammalia Rnf148 34 16 35
  • 83.11 (n)
oppossum
(Monodelphis domestica)
Mammalia RNF148 35
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 33 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 30 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii rnf128a 35
  • 34 (a)
ManyToMany
si:dkeyp-86f7.4 35
  • 33 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea H10E21.5 35
  • 14 (a)
OneToMany
Species where no ortholog for RNF148 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RNF148 Gene

ENSEMBL:
Gene Tree for RNF148 (if available)
TreeFam:
Gene Tree for RNF148 (if available)

Paralogs for RNF148 Gene

(5) SIMAP similar genes for RNF148 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RNF148: view

Variants for RNF148 Gene

Sequence variations from dbSNP and Humsavar for RNF148 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs113197000 -- 122,701,296(+) GGACA(C/T)GGATG intron-variant
rs117448502 -- 122,704,717(+) TGCCC(C/T)CGTCT intron-variant, upstream-variant-2KB
rs117586487 -- 122,702,945(+) ACAAA(A/G)TAACA intron-variant, utr-variant-5-prime
rs117830557 -- 122,702,831(+) GCTTG(C/T)TGGCG intron-variant, utr-variant-5-prime
rs118066697 -- 122,704,048(+) GTATA(C/G)GTTAT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RNF148 Gene

Variant ID Type Subtype PubMed ID
esv3891198 CNV gain 25118596

Variation tolerance for RNF148 Gene

Residual Variation Intolerance Score: 49.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.38; 27.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNF148 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNF148

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF148 Gene

Disorders for RNF148 Gene

Relevant External Links for RNF148

Genetic Association Database (GAD)
RNF148
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RNF148

No disorders were found for RNF148 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF148 Gene

Publications for RNF148 Gene

  1. Identification of a novel human testicular interstitial gene, RNF148, and its expression regulated by histone deacetylases. (PMID: 24089095) Liu Y.Q. … Zhang S.Z. (Genet. Mol. Res. 2013) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4 64
  5. Does this have a familiar RING? (PMID: 8744354) Saurin A.J. … Freemont P.S. (Trends Biochem. Sci. 1996) 2 3 64

Products for RNF148 Gene

Sources for RNF148 Gene

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