RNF146 Gene
protein-coding GIFtS: 51
GCID: GC06P127587
|
|
ring finger protein 146
| |
Aliases
for RNF146 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| Ring Finger Protein 1461 2 3 | | E3 Ubiquitin-Protein Ligase RNF1462 | | DJ351K20.11 | | Iduna3 | | Dactylidin3 | | Dactylidin3 | | DKFZp434O14271 | | EC 6.3.2.-3 | | 2610509H23Rik2 | | Iduna3 | | RP3-351K20.12 | | |
| External Ids: | HGNC: 213361 | Entrez Gene: 818472 | Ensembl: ENSG000001185187 | OMIM: 6121375 | UniProtKB: Q9NTX73 |
|---|
| | ORGUL members: | |
|---|
| NONCODE:n411755 n411756 | |
Export aliases for RNF146 gene to outside databasesPrevious GC identifers: GC06P127568 GC06P127629 GC06P125164
Summaries
for RNF146 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: RN146_HUMAN, Q9NTX7Function: E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated (PARsylated) proteins and mediatestheir ubiquitination and subsequent degradation. May regulate many important biological processes, such as cellsurvival and DNA damage response. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination ofPARsylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex. Acts in cooperation withtankyrase proteins (TNKS and TNKS2), which mediate PARsylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS andTNKS2. Recognizes and binds tankyrase-dependent PARsylated proteins via its WWE domain and mediates theirubiquitination, leading to their degradation. Different ubiquitin linkage types have been observed: TNKS2 undergoesubiquination at 'Lys-48' and 'Lys-63', while AXIN1 is only ubiquitinated at 'Lys-48'. May regulate TNKS and TNKS2subcellular location, preventing aggregation at a centrosomal location. Neuroprotective protein. Protects the brainagainst N-methyl-D-aspartate (NMDA) receptor-mediated glutamate excitotoxicity and ischemia, by interfering withPAR-induced cell death, called parthanatos. Prevents nuclear translocation of AIFM1 in a PAR-binding dependent manner.Does not affect PARP1 activation (By similarity). Protects against cell death induced by DNA damaging agents, such asN-methyl-N-nitro-N-nitrosoguanidine (MNNG) and rescues cells from G1 arrest. Promotes cell survival aftergamma-irradiation. Facilitates DNA repair
Gene Wiki entry for RNF146
|
Genomic Views
for RNF146 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_025741.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RNF146 gene promoter:
HFH-3 FOXD1 AP-4 N-Myc SRY S8 Zic1 STAT3 Zic3 En-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for RNF146
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF146 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q22.1-q22.33 Ensembl cytogenetic band: 6q22.33 HGNC cytogenetic band: 6q22.1-q22.33RNF146 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P127587: view genomic region
(about GC identifiers)
Start:
|
127,587,755 bp from pter |
End:
|
127,609,712 bp from pter |
Size:
|
21,958 bases |
Orientation:
|
plus strand |
ORGUL member locations:
Legend (see complete legend)
 |
Proteins
for RNF146 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RN146_HUMAN, Q9NTX7 (See
protein sequence)Recommended Name: E3 ubiquitin-protein ligase RNF146 Size: 359 amino acids; 38950 Da
Subunit: Can form homooligomers. Interacts with PARsylated AXIN1, AXIN2, BLZF1, CASC3, HIST1H1C, IPO7, LIG3, NCL,PARP1, XRCC1, XRCC5 and XRCC6. Interacts with DDB1, DHX15, IQGAP1, LRPPRC, PARP2, PRKDC, RUVBL2, TNKS1 and TNKS2.Binding often leads to interactor ubiquitination, in the presence of the appropriate E1 and E2 enzymes, andproteasomal degradation
Subcellular location: Cytoplasm, cytosol. Nucleus. Note=Translocates to the nucleus after DNA damage, such aslaser-induced DNA breaks, and concentrates at DNA breaks. This translocation requires PARP1 activation and PAR-binding
Miscellaneous: Was named dactylidin after the Greek term 'daktylidi' for ring, 'the thing around the finger'(PubMed:15813938). Was named Iduna after the Norse goddess of protection and eternal youth (PubMed:21602803)
2 PDB 3D structures from  and Proteopedia  for RNF146:2D8T (3D)
3V3L (3D)
Secondary accessions: E1P572 Q6FIB2 Q7L8H4 Q96K03 Q96T06 Q9NTX6Alternative splicing: 2 isoforms: Q9NTX7-1 Q9NTX7-2 Explore the universe of human proteins at neXtProt for RNF146: NX_Q9NTX7
Post-translational modifications:
Ubiquitinated; autoubiquitinated. Polyubiquitinated in the presence of UBE2D1, UBE2D2 and UBE2D3.Multimonoubiquitinated in the presence of UBE2E1. Not ubiquinated in the presence of UBE2H, CDC34, UBE2L3, UBE2L6, norUBE2C. In the absence of PAR, autoubiquitination occurs on Lys-85, Lys-95 and Lys-176 via 'Lys-11' and 'Lys-48'ubiquitin linkages. In the presence of PAR, Lys-131 and Lys-176 are ubiquitinated via 'Lys-6', 'Lys-33' and 'Lys-48'ubiquitin linkages. Autoubiquitination is enhanced upon PAR-binding1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NTX7
RNF146 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (8 alternative transcripts):
NP_001229773.1 NP_001229774.1 NP_001229775.1 NP_001229778.1 NP_001229779.1 NP_001229780.1 NP_001229781.1 NP_112225.2
ENSEMBL proteins: ENSP00000357297 ENSP00000349253 ENSP00000309365
Human Recombinant Protein Products for RNF146:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
RNF146 for ontologies About GeneDecksing
RNF146 Antibody Products:
Assay Products for RNF146: |
Protein
Domains /
Families
for RNF146 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RNF146 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NTX7ProtoNet protein and cluster: Q9NTX7 1 Blocks protein family: IPB001841 Zn-finger
UniProtKB/Swiss-Prot: RN146_HUMAN, Q9NTX7Domain: The WWE domain mediates non-covalent PAR-bindingSimilarity: Contains 1 RING-type zinc fingerSimilarity: Contains 1 WWE domain |
Function
for RNF146 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: RN146_HUMAN, Q9NTX7Function: E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated (PARsylated) proteins and mediatestheir ubiquitination and subsequent degradation. May regulate many important biological processes, such as cellsurvival and DNA damage response. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination ofPARsylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex. Acts in cooperation withtankyrase proteins (TNKS and TNKS2), which mediate PARsylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS andTNKS2. Recognizes and binds tankyrase-dependent PARsylated proteins via its WWE domain and mediates theirubiquitination, leading to their degradation. Different ubiquitin linkage types have been observed: TNKS2 undergoesubiquination at 'Lys-48' and 'Lys-63', while AXIN1 is only ubiquitinated at 'Lys-48'. May regulate TNKS and TNKS2subcellular location, preventing aggregation at a centrosomal location. Neuroprotective protein. Protects the brainagainst N-methyl-D-aspartate (NMDA) receptor-mediated glutamate excitotoxicity and ischemia, by interfering withPAR-induced cell death, called parthanatos. Prevents nuclear translocation of AIFM1 in a PAR-binding dependent manner.Does not affect PARP1 activation (By similarity). Protects against cell death induced by DNA damaging agents, such asN-methyl-N-nitro-N-nitrosoguanidine (MNNG) and rescues cells from G1 arrest. Promotes cell survival aftergamma-irradiation. Facilitates DNA repair Enzyme Number (IUBMB): EC 6.3.2.-1
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
RNF146 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for RNF146:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF146 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF146 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RNF146 (NM_030963) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RNF146 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF146 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF146 |
|
Pathways & Interactions
for RNF146 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
UniProtKB/Swiss-Prot: RN146_HUMAN, Q9NTX7Pathway: Protein modification; protein ubiquitinationInteractions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNF146
STRING Interaction
Network Preview (showing 5 interactants - click image to see 19)
5/20 Interacting proteins for RNF146 (Q9NTX72, 3 ENSP000003093654) via UniProtKB, MINT, STRING, and/or I2D (see all 20) About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016055 | Wnt receptor signaling pathway |
IEA | -- | | GO:0042787 | protein ubiquitination involved in ubiquitin-dependent protein catabolic process |
IMP | -- | | GO:0051865 | protein autoubiquitination |
IDA | -- | | GO:0070936 | protein K48-linked ubiquitination |
IMP | -- | | GO:0090263 | positive regulation of canonical Wnt receptor signaling pathway |
IMP | -- |
RNF146 for ontologies About GeneDecksing
|
Drugs & Compounds
for RNF146 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RNF146
Search CenterWatch for drugs/clinical trials and news about RNF146 / RN146
|
Transcripts
for RNF146 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RNF146 gene (10 alternative transcripts): NM_001242847.1 NM_001242848.1 NM_001242844.1 NM_001242845.1 NM_001242846.1 NM_001242849.1 NM_001242850.1 NM_001242851.1 NM_001242852.1 NM_030963.3 Unigene Cluster for RNF146: Ring finger protein 146 Hs.267120 [show with all ESTs]Unigene Representative Sequence: NM_0012428448 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000368314(uc021zes.1 uc021zew.1 uc003qav.3) ENST00000476956
ENST00000356799(uc021zet.1 uc021zeu.1 uc021zev.1 uc003qat.3 uc021zex.1 uc003qaw.3 uc003qau.3)
ENST00000495188 ENST00000477776 ENST00000489534 ENST00000480444 ENST00000309649
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF146 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF146 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RNF146 (NM_030963) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RNF146 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF146 |
Additional cDNA sequence: AJ315122.1 AJ420549.1 AK027436.1 AK027558.1 AK027776.1 AL136829.1 BC008235.1 CR533514.1 NR_045102.1 NR_045103.1 20 DOTS entries: DT.100821962 DT.86842187 DT.446605 DT.121323263 DT.86842184 DT.92427562 DT.121323275 DT.100036018 DT.100821966 DT.98131864 DT.121323249 DT.100036016 DT.100713547 DT.121323283 DT.121323309 DT.121323214 DT.121323306 DT.91719703 DT.121323267 DT.92326298 24/185 AceView cDNA sequences (see all 185): BE465813 AI871539 CB177936 AI167493 F08962 BM795405 CB178344 AK027558 BE327892 BI760206 AA478838 CB178007 AW468782 AI536652 AI003946 CA446501 AJ315122 BX349164 AI061090 T30267 CR616084 CB851669 NM_030963 CR605085
GeneLoc Exon Structure
5/12 Alternative Splicing Database (ASD) splice patterns (SP) for RNF146 (see all 12) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | · | 1g | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c |
|---|
|
| SP1: | | | | | | | | | | | - | | - | | | | - | | - | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | - | | - | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | | | - | | - | | | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | - | | | | - | | - | | - | | - | | - | | - | | | | | | | |
ECgene alternative splicing isoforms for RNF146
|
Expression
for RNF146 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RNF146 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGTTCCCAT
About this image
See RNF146 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RNF146
SOURCE GeneReport for Unigene cluster: Hs.267120
UniProtKB/Swiss-Prot: RN146_HUMAN, Q9NTX7Tissue specificity: Ubiquitously expressed. Up-regulated in brains from patients with Alzheimer disease
SABiosciences Expression via Pathway-Focused PCR Array including RNF146:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNF146
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RNF146 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNF146 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNF146 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF146 |
Orthologs
for RNF146 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for RNF146 gene from 7/20 species (see all 20) About this table
ENSEMBL Gene Tree for RNF146 (if available)
TreeFam Gene Tree for RNF146 (if available) |
Paralogs
for RNF146 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for RNF146 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RNF146 (127587755 - 127609712 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for RNF146
1 Inversion: 37266 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNF146 |
|
Disorders
/ Diseases
for RNF146 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RNF146 for disorders About GeneDecksing
OMIM gene information: 612137
OMIM disorders: --
UniProtKB/Swiss-Prot: RN146_HUMAN, Q9NTX7
Note=Defects in RNF146 are a cause of susceptibility to breast cancer
6  diseases for RNF146: About MalaCardsbreast cancer susceptibility cherubism breast-ovarian cancer breast cancer
ovarian cancer alzheimer's disease
Human Genome Epidemiology (HuGE) Navigator: RNF146 (3 documents)
Export disorders for RNF146 gene to outside databases
|
Publications
for RNF146 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RNF146 gene, integrated from 9 sources (see all 26):
(articles sorted by number of sources associating them with RNF146) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The novel cytosolic RING finger protein dactylidin is up-regulated in brains of patients with Alzheimer's disease. (PubMed id 15813938)1, 2, 9 von Rotz R.C....Nitsch R.M. (2005)
- Recognition of the iso-ADP-ribose moiety in poly(ADP-r ibose) by WWE domains suggests a general mechanism for poly(ADP-ribosyl)ation-de pendent ubiquitination. (PubMed id 22267412)1, 2 Wang Z....Xu W. (2012)
- Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiqui tin ligase that regulates DNA damage. (PubMed id 21825151)1, 2 Kang H.C....Dawson T.M. (2011)
- Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling. (PubMed id 21799911)1, 2 Callow M.G....Costa M. (2011)
- RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling. (PubMed id 21478859)1, 2 Zhang Y.... Cong F. (2011)
- The RNF146 and ECHDC1 genes as candidates for inherit ed breast and ovarian cancer in Jewish Ashkenazi women. (PubMed id 19517271)1, 2 Menachem T.D....Friedman E. (2009)
- Genome-wide association study provides evidence for a breast cancer risk locus at 6q22.33. (PubMed id 18326623)1, 2 Gold B....Offit K. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
|
External Searches for RNF146 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RNF146 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RNF146 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RNF146 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RNF146 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RNF146 gene:
Search GeneIP for patents involving RNF146
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for RNF146 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RNF146 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RNF146 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNF146 | | | OriGene Protein Over-expression Lysate for RNF146 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for RNF146 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF146 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF146 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RNF146 | | OriGene Custom Protein Services for RNF146 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RNF146 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNF146 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF146 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNF146 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNF146 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNF146 |
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| | | | Search Tocris compounds for RNF146 |
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 | | | RNF146 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF146 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for RNF146 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF146 |
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Last full update: 18 Mar 2013 -
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