RNF145 Gene
protein-coding GIFtS: 44
GCID: GC05M158517
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|
ring finger protein 145
| |
Aliases
for RNF145 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ring Finger Protein 1451 2 | | FLJ319511 |
Export aliases for RNF145 gene to outside databasesPrevious GC identifers: GC00U911618 GC05M153679 |
Summaries
for RNF145 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for RNF145 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_023133.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RNF145 gene promoter:
AP-1 Pax-5 POU3F2 (N-Oct-5b) POU3F2 (N-Oct-5a) POU3F2 E4BP4 RORalpha2 YY1 FOXL1 AREB6
Other transcription factors
Search SABiosciences Chromatin IP Primers for RNF145
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF145 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q33.3 Ensembl cytogenetic band: 5q33.3 HGNC cytogenetic band: 5q33.3RNF145 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M158517: view genomic region
(about GC identifiers)
Start:
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158,584,417 bp from pter |
End:
|
158,637,061 bp from pter |
Size:
|
52,645 bases |
Orientation:
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minus strand |
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Proteins
for RNF145 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RN145_HUMAN, Q96MT1 (See
protein sequence)Recommended Name: RING finger protein 145 Size: 663 amino acids; 75617 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=AK308394; Type=Frameshift; Positions=189;
Secondary accessions: B7Z903 B7Z949 E7EVI7 Q8IVP7Alternative splicing: 5 isoforms: Q96MT1-1 Q96MT1-2 Q96MT1-3 Q96MT1-4 Q96MT1-5 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for RNF145: NX_Q96MT1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96MT1
RNF145 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (5 alternative transcripts):
NP_001186309.1 NP_001186310.1 NP_001186311.1 NP_001186312.1 NP_653327.1
ENSEMBL proteins: ENSP00000274542 ENSP00000430397 ENSP00000409064 ENSP00000430753 ENSP00000430955 ENSP00000429071 ENSP00000445115 ENSP00000442941
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
RNF145 for ontologies About GeneDecksing
RNF145 Antibody Products:
Assay Products for RNF145: |
Protein
Domains /
Families
for RNF145 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RNF145 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96MT1ProtoNet protein and cluster: Q96MT1 1 Blocks protein family: IPB001841 Zn-finger
UniProtKB/Swiss-Prot: RN145_HUMAN, Q96MT1Similarity: Contains 1 RING-type zinc finger |
Function
for RNF145 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF145 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF145
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector (see all 5): RNF145 (NM_001199380) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RNF145 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF145 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF145 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008270 | zinc ion binding |
IEA | -- |
RNF145 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for RNF145:
|
Pathways & Interactions
for RNF145 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNF145
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for RNF145 (ENSP000002745424) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for RNF145 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RNF145
Search CenterWatch for drugs/clinical trials and news about RNF145 / RN145
|
Transcripts
for RNF145 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RNF145 gene (5 alternative transcripts): NM_001199380.1 NM_001199381.1 NM_001199382.1 NM_001199383.1 NM_144726.2 Unigene Cluster for RNF145: Ring finger protein 145 Hs.349306 [show with all ESTs]Unigene Representative Sequence: BC04268413 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000274542(uc011ddy.2 uc003lxo.2 uc010jiq.2) ENST00000519865(uc011ddz.2)
ENST00000424310(uc003lxp.3) ENST00000518284 ENST00000519985 ENST00000521606(uc011dea.2)
ENST00000518802 ENST00000520638 ENST00000518062 ENST00000521266 ENST00000520548
ENST00000413445 ENST00000535312
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF145 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF145
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 5): RNF145 (NM_001199380) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RNF145 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF145 |
Additional cDNA sequence: AK056513.1 AK075101.1 AK098802.1 AK292854.1 AK294323.1 AK304228.1 AK304435.1 AK308394.1 AK311433.1 AL831829.1 BC042684.1 BC044767.1 BX640806.1 11 DOTS entries: DT.101975600 DT.311350 DT.40298359 DT.100722041 DT.121067121 DT.304758 DT.40247138 DT.97768336 DT.120885141 DT.121040816 DT.95375722 24/136 AceView cDNA sequences (see all 136): AL831829 BE350482 CD518684 AW613066 AI246159 AI925481 AL553941 CR616646 CA952897 AW196841 NM_144726 AA969419 AA576941 CA942073 AI628661 BU680515 BG054674 BQ940178 AA479920 AA428508 BF431361 AA806280 BX281856 AI333134
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for RNF145 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11a | · | 11b |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for RNF145
|
Expression
for RNF145 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RNF145 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCTACAGGTA
About this image
See RNF145 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RNF145
SOURCE GeneReport for Unigene cluster: Hs.349306
SABiosciences Expression via Pathway-Focused PCR Array including RNF145:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNF145
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RNF145 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNF145 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNF145 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF145 |
Orthologs
for RNF145 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for RNF145 gene from 6/16 species (see all 16) About this table
ENSEMBL Gene Tree for RNF145 (if available)
TreeFam Gene Tree for RNF145 (if available) |
Paralogs
for RNF145 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RNF145 gene
- SYVN12 AMFR2 RNF1392
3 SIMAP similar genes for RNF145 using alignment to 2 protein entries: RN145_HUMAN (see all proteins):DKFZp547B0914 DKFZp686M11215 DKFZp686M20237
RNF145 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for RNF145
PGOHUM00000246621 PGOHUM00000246670
|
Genomic Variants
for RNF145 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RNF145 (158584417 - 158637061 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for RNF145
1 CNV: 99334
6 Indels: 62448 40810 60567 46796 42776 27839 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNF145 |
|
Disorders
/ Diseases
for RNF145 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for RNF145 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RNF145 gene integrated from 9 sources:
(articles sorted by number of sources associating them with RNF145) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- New gene functions in megakaryopoiesis and platelet fo rmation. (PubMed id 22139419)1 Gieger C....Soranzo N. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- A genome-wide meta-analysis identifies 22 loci associ ated with eight hematological parameters in the HaemGen consortium. (PubMed id 19820697)1 Soranzo N....Gieger C. (2009)
- Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1 Otsuki T....Isogai T. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)2 Schmutz J.... Rubin E.M. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for RNF145 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RNF145 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RNF145 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RNF145 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RNF145 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RNF145 gene:
Search GeneIP for patents involving RNF145
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RNF145 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RNF145 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RNF145 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNF145 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RNF145 | | OriGene 3'-UTR Clone for RNF145 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF145 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF145 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RNF145 | | OriGene Custom Protein Services for RNF145 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RNF145 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNF145 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF145 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNF145 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNF145 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNF145 |
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 | | | RNF145 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF145 |
|  |  |  | | | | Search ThermoFisher Antibodies for RNF145 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF145 |
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