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Aliases for RNF145 Gene

Aliases for RNF145 Gene

  • Ring Finger Protein 145 2 3 5

External Ids for RNF145 Gene

Previous GeneCards Identifiers for RNF145 Gene

  • GC00U911618
  • GC05M158517
  • GC05M153679

Summaries for RNF145 Gene

GeneCards Summary for RNF145 Gene

RNF145 (Ring Finger Protein 145) is a Protein Coding gene. An important paralog of this gene is AMFR.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF145 Gene

Genomics for RNF145 Gene

Regulatory Elements for RNF145 Gene

Enhancers for RNF145 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RNF145 on UCSC Golden Path with GeneCards custom track

Genomic Location for RNF145 Gene

159,157,409 bp from pter
159,210,053 bp from pter
52,645 bases
Minus strand

Genomic View for RNF145 Gene

Genes around RNF145 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF145 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF145 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF145 Gene

Proteins for RNF145 Gene

  • Protein details for RNF145 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RING finger protein 145
    Protein Accession:
    Secondary Accessions:
    • B7Z903
    • B7Z949
    • E7EVI7
    • Q8IVP7

    Protein attributes for RNF145 Gene

    663 amino acids
    Molecular mass:
    75617 Da
    Quaternary structure:
    No Data Available
    • Sequence=AK308394; Type=Frameshift; Positions=189; Evidence={ECO:0000305};

    Alternative splice isoforms for RNF145 Gene


neXtProt entry for RNF145 Gene

Proteomics data for RNF145 Gene at MOPED

Post-translational modifications for RNF145 Gene

  • Ubiquitination at Lys 507, Lys 520, Lys 527, Lys 532, Lys 545, and Lys 563
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RNF145 Gene

Domains & Families for RNF145 Gene

Gene Families for RNF145 Gene

Protein Domains for RNF145 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 RING-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF145: view

Function for RNF145 Gene

Gene Ontology (GO) - Molecular Function for RNF145 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with RNF145: view
genes like me logo Genes that share phenotypes with RNF145: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RNF145

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNF145 Gene

Localization for RNF145 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF145 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for RNF145 Gene COMPARTMENTS Subcellular localization image for RNF145 gene
Compartment Confidence
plasma membrane 4
cytosol 2
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for RNF145 Gene

Pathways & Interactions for RNF145 Gene

SuperPathways for RNF145 Gene

No Data Available

Interacting Proteins for RNF145 Gene

Gene Ontology (GO) - Biological Process for RNF145 Gene


No data available for Pathways by source and SIGNOR curated interactions for RNF145 Gene

Drugs & Compounds for RNF145 Gene

No Compound Related Data Available

Transcripts for RNF145 Gene

Unigene Clusters for RNF145 Gene

Ring finger protein 145:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNF145 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b
SP1: -
SP2: -

Relevant External Links for RNF145 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNF145 Gene

mRNA expression in normal human tissues for RNF145 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RNF145 Gene

SOURCE GeneReport for Unigene cluster for RNF145 Gene Hs.349306

genes like me logo Genes that share expression patterns with RNF145: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for RNF145 Gene

Orthologs for RNF145 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RNF145 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RNF145 35
  • 92.08 (n)
  • 95.31 (a)
RNF145 36
  • 89 (a)
(Canis familiaris)
Mammalia RNF145 35
  • 93.14 (n)
  • 96.82 (a)
RNF145 36
  • 94 (a)
(Mus musculus)
Mammalia Rnf145 35
  • 85.77 (n)
  • 93.82 (a)
Rnf145 16
Rnf145 36
  • 94 (a)
(Pan troglodytes)
Mammalia RNF145 35
  • 99.52 (n)
  • 99.42 (a)
RNF145 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Rnf145 35
  • 86.48 (n)
  • 94.57 (a)
(Monodelphis domestica)
Mammalia RNF145 36
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia RNF145 36
  • 89 (a)
(Gallus gallus)
Aves RNF145 35
  • 80.1 (n)
  • 91.3 (a)
RNF145 36
  • 97 (a)
(Anolis carolinensis)
Reptilia RNF145 36
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf145 35
  • 75.62 (n)
  • 89.42 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.31936 35
(Danio rerio)
Actinopterygii wufa20f10 35
RNF145 (1 of 2) 36
  • 82 (a)
rnf145b 36
  • 77 (a)
(Caenorhabditis elegans)
Secernentea Y119C1B.5 36
  • 23 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HRD1 36
  • 13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3828 36
  • 39 (a)
Species with no ortholog for RNF145:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RNF145 Gene

Gene Tree for RNF145 (if available)
Gene Tree for RNF145 (if available)

Paralogs for RNF145 Gene

Paralogs for RNF145 Gene

(2) SIMAP similar genes for RNF145 Gene using alignment to 1 proteins: Pseudogenes for RNF145 Gene

genes like me logo Genes that share paralogs with RNF145: view

Variants for RNF145 Gene

Sequence variations from dbSNP and Humsavar for RNF145 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs919743 -- 159,211,860(+) TGGGG(C/T)GGGTG upstream-variant-2KB
rs975023 -- 159,172,929(+) TTTTA(A/G)AGTGA intron-variant
rs975024 -- 159,173,292(+) TTTTA(C/T)GTATA intron-variant
rs2901183 -- 159,201,179(+) ACCCA(C/T)GTATA intron-variant
rs1137598 -- 159,196,329(-) cttcc(A/C)tggac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNF145 Gene

Variant ID Type Subtype PubMed ID
esv2604737 CNV Deletion 19546169
esv1940942 CNV Deletion 18987734
esv3302 CNV Deletion 18987735
esv2730969 CNV Deletion 23290073
esv1006507 CNV Deletion 20482838
esv1085574 CNV Deletion 17803354
esv7930 CNV Loss 19470904
esv5760 CNV Gain 19470904

Variation tolerance for RNF145 Gene

Residual Variation Intolerance Score: 49.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.85; 17.81% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RNF145 Gene

Disorders for RNF145 Gene

Relevant External Links for RNF145

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RNF145 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF145 Gene

Publications for RNF145 Gene

  1. A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. (PMID: 19820697) Soranzo N. … Gieger C. (Nat. Genet. 2009) 3 48 67
  2. New gene functions in megakaryopoiesis and platelet formation. (PMID: 22139419) Gieger C. … Soranzo N. (Nature 2011) 3
  3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for RNF145 Gene

Sources for RNF145 Gene