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Aliases for RNF145 Gene

Aliases for RNF145 Gene

  • Ring Finger Protein 145 2 3 5

External Ids for RNF145 Gene

Previous GeneCards Identifiers for RNF145 Gene

  • GC00U911618
  • GC05M158517
  • GC05M153679

Summaries for RNF145 Gene

GeneCards Summary for RNF145 Gene

RNF145 (Ring Finger Protein 145) is a Protein Coding gene. An important paralog of this gene is RNF139.

Additional gene information for RNF145 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF145 Gene

Genomics for RNF145 Gene

Regulatory Elements for RNF145 Gene

Enhancers for RNF145 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H159094 1.9 FANTOM5 Ensembl ENCODE dbSUPER 18.6 +111.7 111722 7 HDGF PKNOX1 ARNT SIN3A FEZF1 YBX1 ZNF2 ZNF143 SP3 REST RNF145 LINC02202 LINC01845 ENSG00000253424 EBF1 ENSG00000253456 GC05P159069
GH05H159177 1.9 FANTOM5 Ensembl ENCODE dbSUPER 17.1 +27.8 27768 9 PKNOX1 FOXA2 ATF1 ARID4B SIN3A ZNF121 KLF7 ATF7 FOS RUNX3 RNF145 ENSG00000253256 UBLCP1 ENSG00000252458 IL12B GC05M159165
GH05H160008 1.1 ENCODE 26.7 -799.5 -799467 2 HDGF PKNOX1 ZFP64 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF302 ZNF143 ZBED8 PWWP2A EBF1 LINC02202 RNF145 C1QTNF2 LINC01845 ENSG00000223908 TTC1 FABP6
GH05H159240 1.4 FANTOM5 ENCODE 13.5 -30.5 -30510 0 PKNOX1 ATF1 SIN3A FEZF1 GATA2 ATF7 FOS TSHZ1 MEF2D SMARCA4 RNF145 ENSG00000253256 UBLCP1 IL12B GC05P159231 PIR58735
GH05H159204 1.7 Ensembl ENCODE dbSUPER 10.9 +1.6 1560 7 PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 LINC01845 ENSG00000253424 ENSG00000253456 RNF145 ENSG00000253256 GC05M159165
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RNF145 on UCSC Golden Path with GeneCards custom track

Promoters for RNF145 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000189826 1853 3601 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 CBX5 ZNF143

Genomic Location for RNF145 Gene

Chromosome:
5
Start:
159,157,409 bp from pter
End:
159,210,053 bp from pter
Size:
52,645 bases
Orientation:
Minus strand

Genomic View for RNF145 Gene

Genes around RNF145 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF145 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF145 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF145 Gene

Proteins for RNF145 Gene

  • Protein details for RNF145 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96MT1-RN145_HUMAN
    Recommended name:
    RING finger protein 145
    Protein Accession:
    Q96MT1
    Secondary Accessions:
    • B7Z903
    • B7Z949
    • E7EVI7
    • Q8IVP7

    Protein attributes for RNF145 Gene

    Size:
    663 amino acids
    Molecular mass:
    75617 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AK308394; Type=Frameshift; Positions=189; Evidence={ECO:0000305};

    Alternative splice isoforms for RNF145 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNF145 Gene

Post-translational modifications for RNF145 Gene

  • Ubiquitination at isoforms=2, 3, 4, 5507, isoforms=2, 3, 4, 5520, isoforms=2, 3, 4, 5527, isoforms=2, 3, 4, 5532, Lys545, and isoforms=2, 3, 4, 5563
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RNF145 Gene

Domains & Families for RNF145 Gene

Gene Families for RNF145 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for RNF145 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RNF145: view

No data available for UniProtKB/Swiss-Prot for RNF145 Gene

Function for RNF145 Gene

Phenotypes From GWAS Catalog for RNF145 Gene

Gene Ontology (GO) - Molecular Function for RNF145 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
GO:0061630 ubiquitin protein ligase activity IBA --
genes like me logo Genes that share ontologies with RNF145: view
genes like me logo Genes that share phenotypes with RNF145: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RNF145

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for RNF145
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNF145 Gene

Localization for RNF145 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF145 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNF145 gene
Compartment Confidence
plasma membrane 4
nucleus 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RNF145 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RNF145: view

Pathways & Interactions for RNF145 Gene

SuperPathways for RNF145 Gene

No Data Available

Interacting Proteins for RNF145 Gene

Gene Ontology (GO) - Biological Process for RNF145 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IBA --
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA --
genes like me logo Genes that share ontologies with RNF145: view

No data available for Pathways by source and SIGNOR curated interactions for RNF145 Gene

Drugs & Compounds for RNF145 Gene

No Compound Related Data Available

Transcripts for RNF145 Gene

Unigene Clusters for RNF145 Gene

Ring finger protein 145:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for RNF145
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for RNF145 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b
SP1: -
SP2: -
SP3:

Relevant External Links for RNF145 Gene

GeneLoc Exon Structure for
RNF145
ECgene alternative splicing isoforms for
RNF145

Expression for RNF145 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNF145 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RNF145 Gene



NURSA nuclear receptor signaling pathways regulating expression of RNF145 Gene:

RNF145

SOURCE GeneReport for Unigene cluster for RNF145 Gene:

Hs.349306
genes like me logo Genes that share expression patterns with RNF145: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNF145 Gene

Orthologs for RNF145 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RNF145 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNF145 33 34
  • 99.52 (n)
dog
(Canis familiaris)
Mammalia RNF145 33 34
  • 93.14 (n)
cow
(Bos Taurus)
Mammalia RNF145 33 34
  • 92.08 (n)
oppossum
(Monodelphis domestica)
Mammalia RNF145 34
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RNF145 34
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnf145 33
  • 86.48 (n)
mouse
(Mus musculus)
Mammalia Rnf145 33 16 34
  • 85.77 (n)
chicken
(Gallus gallus)
Aves RNF145 33 34
  • 80.1 (n)
lizard
(Anolis carolinensis)
Reptilia RNF145 34
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf145 33
  • 75.62 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.31936 33
zebrafish
(Danio rerio)
Actinopterygii RNF145 (1 of 2) 34
  • 82 (a)
OneToMany
rnf145b 34
  • 77 (a)
OneToMany
wufa20f10 33
worm
(Caenorhabditis elegans)
Secernentea Y119C1B.5 34
  • 23 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HRD1 34
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3828 34
  • 39 (a)
OneToOne
Species where no ortholog for RNF145 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RNF145 Gene

ENSEMBL:
Gene Tree for RNF145 (if available)
TreeFam:
Gene Tree for RNF145 (if available)

Paralogs for RNF145 Gene

Paralogs for RNF145 Gene

(2) SIMAP similar genes for RNF145 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for RNF145 Gene

genes like me logo Genes that share paralogs with RNF145: view

Variants for RNF145 Gene

Sequence variations from dbSNP and Humsavar for RNF145 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000048061 -- 159,189,902(+) GCTGG(A/G)GGCAG intron-variant
rs1000066113 -- 159,176,346(+) TTACA(C/G)AAAGT intron-variant
rs1000067933 -- 159,195,683(+) GGAAA(A/T)TTGGT intron-variant
rs1000120060 -- 159,196,041(+) ATTCC(A/C)ACCTC intron-variant
rs1000127447 -- 159,202,896(+) GTTCC(A/G)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNF145 Gene

Variant ID Type Subtype PubMed ID
dgv3203n106 CNV deletion 24896259
esv1006507 CNV deletion 20482838
esv1085574 CNV deletion 17803354
esv1940942 CNV deletion 18987734
esv2604737 CNV deletion 19546169
esv2730969 CNV deletion 23290073
esv3302 CNV loss 18987735
esv3566878 CNV deletion 23714750
esv5760 CNV gain 19470904
esv7930 CNV loss 19470904
nsv1073509 CNV deletion 25765185
nsv1144122 CNV deletion 24896259
nsv475532 CNV novel sequence insertion 20440878
nsv955756 CNV deletion 24416366

Variation tolerance for RNF145 Gene

Residual Variation Intolerance Score: 49.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.85; 17.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNF145 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNF145

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF145 Gene

Disorders for RNF145 Gene

Relevant External Links for RNF145

Genetic Association Database (GAD)
RNF145
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RNF145

No disorders were found for RNF145 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF145 Gene

Publications for RNF145 Gene

  1. A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. (PMID: 19820697) Soranzo N … Gieger C (Nature genetics 2009) 3 45 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. Gene essentiality and synthetic lethality in haploid human cells. (PMID: 26472760) Blomen VA … Brummelkamp TR (Science (New York, N.Y.) 2015) 3 60
  4. New gene functions in megakaryopoiesis and platelet formation. (PMID: 22139419) Gieger C … Soranzo N (Nature 2011) 3 60
  5. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 60

Products for RNF145 Gene

Sources for RNF145 Gene

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