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Aliases for RNF145 Gene

Aliases for RNF145 Gene

  • Ring Finger Protein 145 2 3

External Ids for RNF145 Gene

Summaries for RNF145 Gene

GeneCards Summary for RNF145 Gene

RNF145 (Ring Finger Protein 145) is a Protein Coding gene. An important paralog of this gene is AMFR.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF145 Gene

Genomics for RNF145 Gene

Genomic Location for RNF145 Gene

Start:
159,157,409 bp from pter
End:
159,210,053 bp from pter
Size:
52,645 bases
Orientation:
Minus strand

Genomic View for RNF145 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNF145 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF145 Gene

Regulatory Elements for RNF145 Gene

Proteins for RNF145 Gene

  • Protein details for RNF145 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96MT1-RN145_HUMAN
    Recommended name:
    RING finger protein 145
    Protein Accession:
    Q96MT1
    Secondary Accessions:
    • B7Z903
    • B7Z949
    • E7EVI7
    • Q8IVP7

    Protein attributes for RNF145 Gene

    Size:
    663 amino acids
    Molecular mass:
    75617 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AK308394; Type=Frameshift; Positions=189; Evidence={ECO:0000305};

    Alternative splice isoforms for RNF145 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNF145 Gene

Proteomics data for RNF145 Gene at MOPED

Post-translational modifications for RNF145 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys507, Lys520, Lys527, Lys532, Lys545, and Lys563

No data available for DME Specific Peptides for RNF145 Gene

Domains for RNF145 Gene

Gene Families for RNF145 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for RNF145 Gene

UniProtKB/Swiss-Prot:

RN145_HUMAN
Similarity:
  • Contains 1 RING-type zinc finger.:
    • Q96MT1
genes like me logo Genes that share domains with RNF145: view

Function for RNF145 Gene

Gene Ontology (GO) - Molecular Function for RNF145 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with RNF145: view

Phenotypes for RNF145 Gene

GenomeRNAi human phenotypes for RNF145:
genes like me logo Genes that share phenotypes with RNF145: view

miRNA for RNF145 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RNF145 Gene

Localization for RNF145 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF145 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNF145 Gene COMPARTMENTS Subcellular localization image for RNF145 gene
Compartment Confidence
plasma membrane 3
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RNF145 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RNF145: view

Pathways for RNF145 Gene

SuperPathways for RNF145 Gene

No Data Available

Interacting Proteins for RNF145 Gene

Gene Ontology (GO) - Biological Process for RNF145 Gene

None

No data available for Pathways by source for RNF145 Gene

Transcripts for RNF145 Gene

Unigene Clusters for RNF145 Gene

Ring finger protein 145:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNF145 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b
SP1: -
SP2: -
SP3:

Relevant External Links for RNF145 Gene

GeneLoc Exon Structure for
RNF145
ECgene alternative splicing isoforms for
RNF145

Expression for RNF145 Gene

mRNA expression in normal human tissues for RNF145 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RNF145 Gene

SOURCE GeneReport for Unigene cluster for RNF145 Gene Hs.349306

genes like me logo Genes that share expressions with RNF145: view

Orthologs for RNF145 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RNF145 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNF145 36
  • 99.52 (n)
  • 99.42 (a)
RNF145 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RNF145 36
  • 92.08 (n)
  • 95.31 (a)
RNF145 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNF145 36
  • 93.14 (n)
  • 96.82 (a)
RNF145 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnf145 36
  • 85.77 (n)
  • 93.82 (a)
Rnf145 16
Rnf145 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RNF145 37
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RNF145 37
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnf145 36
  • 86.48 (n)
  • 94.57 (a)
chicken
(Gallus gallus)
Aves RNF145 36
  • 80.1 (n)
  • 91.3 (a)
RNF145 37
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RNF145 37
  • 87 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.31936 36
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf145 36
  • 75.62 (n)
  • 89.42 (a)
zebrafish
(Danio rerio)
Actinopterygii RNF145 (1 of 2) 37
  • 82 (a)
OneToMany
rnf145b 37
  • 77 (a)
OneToMany
wufa20f10 36
worm
(Caenorhabditis elegans)
Secernentea Y119C1B.5 37
  • 23 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HRD1 37
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3828 37
  • 39 (a)
OneToOne
Species with no ortholog for RNF145:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RNF145 Gene

ENSEMBL:
Gene Tree for RNF145 (if available)
TreeFam:
Gene Tree for RNF145 (if available)

Paralogs for RNF145 Gene

Paralogs for RNF145 Gene

Selected SIMAP similar genes for RNF145 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for RNF145 Gene

genes like me logo Genes that share paralogs with RNF145: view

Variants for RNF145 Gene

Sequence variations from dbSNP and Humsavar for RNF145 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs919743 -- 159,211,860(+) TGGGG(C/T)GGGTG upstream-variant-2KB
rs975023 -- 159,172,929(+) TTTTA(A/G)AGTGA intron-variant
rs975024 -- 159,173,292(+) TTTTA(C/T)GTATA intron-variant
rs1137598 -- 159,196,329(-) cttcc(A/C)tggac intron-variant
rs1368373 -- 159,210,123(+) TATTG(C/T)AGTAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RNF145 Gene

Variant ID Type Subtype PubMed ID
esv2604737 CNV Deletion 19546169
esv1940942 CNV Deletion 18987734
esv3302 CNV Deletion 18987735
esv2730969 CNV Deletion 23290073
esv1006507 CNV Deletion 20482838
esv1085574 CNV Deletion 17803354
esv7930 CNV Loss 19470904
esv5760 CNV Gain 19470904

Relevant External Links for RNF145 Gene

HapMap Linkage Disequilibrium report
RNF145

Disorders for RNF145 Gene

Relevant External Links for RNF145

Genetic Association Database (GAD)
RNF145
genes like me logo Genes that share disorders with RNF145: view

No data available for UniProtKB/Swiss-Prot for RNF145 Gene

Publications for RNF145 Gene

  1. A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. (PMID: 19820697) Soranzo N. … Gieger C. (Nat. Genet. 2009) 3 49
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3

Products for RNF145 Gene

Sources for RNF145 Gene

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