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RNF144B Gene

protein-coding   GIFtS: 55
GCID: GC06P018368

Ring Finger Protein 144B

(Previous name: IBR domain containing 2)
(Previous symbol: IBRDC2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ring Finger Protein 144B1 2 3     bA528A10.32
IBRDC21 2 3     E3 Ubiquitin-Protein Ligase RNF144B2
IBR Domain Containing 21 2     p53RFP2
IBR Domain-Containing Protein 22 3     EC 6.3.2.-3
P53-Inducible RING Finger Protein2 3     P53RFP3
PIR22     EC 6.3.28

External Ids:    HGNC: 215781   Entrez Gene: 2554882   Ensembl: ENSG000001373937   UniProtKB: Q7Z4193   

Export aliases for RNF144B gene to outside databases

Previous GC identifer: GC06P018496


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RNF144B Gene:
RNF144B (ring finger protein 144B) is a protein-coding gene. GO annotations related to this gene include ubiquitin-protein ligase activity. An important paralog of this gene is ANKIB1.

UniProtKB/Swiss-Prot: R144B_HUMAN, Q7Z419
Function: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and
UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2,
thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent
mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a
pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein
per se




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_007592.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RNF144B gene promoter:
         COUP-TF1   STAT5B   MyoD   COUP   HNF-4alpha2   HNF-4alpha1   PPAR-gamma1   COUP-TF   PPAR-gamma2   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNF144B promoter sequence
   Search Chromatin IP Primers for RNF144B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNF144B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.3   Ensembl cytogenetic band:  6p22.3   HGNC cytogenetic band: 6p22.3

RNF144B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF144B gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P018368:  view genomic region     (about GC identifiers)

Start:
18,368,779 bp from pter      End:
18,469,105 bp from pter
Size:
100,327 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: R144B_HUMAN, Q7Z419 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase RNF144B  
Size: 303 amino acids; 33697 Da
Subunit: Interacts with UBE2L3, UBE2L6 and LCMT2, as well as with BAX
Caution: Lacks the His residue in the RING-type domain 2 that is one of the conserved features of the family
Sequence caution: Sequence=CAD38622.1; Type=Erroneous initiation;
Secondary accessions: B3KUA8 Q5TB85 Q6P4Q0 Q8N3R7 Q9BX38

Explore the universe of human proteins at neXtProt for RNF144B: NX_Q7Z419

Explore proteomics data for RNF144B at MOPED

Post-translational modifications: 

  • Auto-ubiquitinated1
  • Modification sites at neXtProt
  • 2 DME Specific Peptides for RNF144B (Q7Z419)
     EGCAQMMCKNCKH  GPCRNKLGHSRASV 


    See RNF144B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_877434.2  
    ENSEMBL proteins: 
     ENSP00000259939   ENSP00000411270  
    Reactome Protein details: Q7Z419

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers

    3 InterPro protein domains:
     IPR017907 Znf_RING_CS
     IPR002867 Znf_C6HC
     IPR001841 Znf_RING

    Graphical View of Domain Structure for InterPro Entry Q7Z419

    ProtoNet protein and cluster: Q7Z419

    2 Blocks protein domains:
    IPB001841 Zn-finger
    IPB002867 Zn-finger


    UniProtKB/Swiss-Prot: R144B_HUMAN, Q7Z419
    Domain: The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme (By similarity).
    The transmembrane domain is essential for translocation to the mitochondria upon induction of apoptosis
    Similarity: Belongs to the RBR family. RNF144 subfamily
    Similarity: Contains 1 IBR-type zinc finger
    Similarity: Contains 2 RING-type zinc fingers


    Find genes that share domains with RNF144B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: R144B_HUMAN, Q7Z419
    Function: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and
    UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2,
    thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent
    mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a
    pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein
    per se

         Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IDA12853982
    GO:0005515protein binding IPI12853982
    GO:0008270zinc ion binding IEA--
    GO:0016874ligase activity ----
         
    Find genes that share ontologies with RNF144B           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for RNF144B:
     Increased G1 DNA content  Increased gamma-H2AX phosphory 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for RNF144B

    miRNA
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    miRTarBase miRNAs that target RNF144B:
    hsa-mir-16-5p (MIRT031928), hsa-mir-103a-3p (MIRT027180), hsa-mir-124-3p (MIRT022961), hsa-mir-128-3p (MIRT022046)

    Block miRNA regulation of human, mouse, rat RNF144B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RNF144B (see all 57):
    hsa-miR-3130-5p hsa-miR-607 hsa-miR-15a hsa-miR-4272 hsa-miR-503 hsa-miR-29a hsa-miR-342-3p hsa-miR-650
    SwitchGear 3'UTR luciferase reporter plasmidRNF144B 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    R144B_HUMAN, Q7Z419: Mitochondrion membrane; Single-pass membrane protein. Cytoplasm. Note=Mostly cytosololic,
    accumulates in submitochondrial domains specifically upon apoptosis induction, in synchrony with BAX activation
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    nucleus3
    plasma membrane3

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex IC12853982
    GO:0005737cytoplasm IDA--
    GO:0016021integral component of membrane IEA--
    GO:0031966mitochondrial membrane IDA--

    Find genes that share ontologies with RNF144B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RNF144B About    
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84
    2Gastric cancer network 2
    Gastric cancer network 2
    3Direct p53 effectors
    Direct p53 effectors


    Find genes that share SuperPaths with RNF144B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for RNF144B
        Gastric cancer network 2
    Direct p53 effectors


    1 Reactome Pathway for RNF144B
        Antigen processing: Ubiquitination & Proteasome degradation


    UniProtKB/Swiss-Prot: R144B_HUMAN, Q7Z419
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Arrays including RNF144B: 

              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for RNF144B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    Selected Interacting proteins for RNF144B (Q7Z4191, 2, 3 ENSP000002599394) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BAXQ078121, 2, 3, ENSP000002932884EBI-2129982,EBI-516580 MINT-7948862 MINT-7949239 MINT-7949262 MINT-7948774 MINT-7949221 I2D: score=2 STRING: ENSP00000293288
    UBE2L6O149331, 2, 3, ENSP000002871564EBI-2129982,EBI-2129974 MINT-1771917 MINT-1771944 I2D: score=4 STRING: ENSP00000287156
    TOMM20Q153882, 3, ENSP000003555664MINT-7945209 MINT-7945674 MINT-7949017 I2D: score=1 STRING: ENSP00000355566
    CYCSP999992, 3, ENSP000003077864MINT-7944749 MINT-7949203 I2D: score=1 STRING: ENSP00000307786
    UBE2IP632793, ENSP000003248974I2D: score=2 STRING: ENSP00000324897
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0042787protein ubiquitination involved in ubiquitin-dependent protein catabolic process IDA12853982

    Find genes that share ontologies with RNF144B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RNF144B (R144B)

    4 HMDB Compounds for RNF144B    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RNF144B gene: 
    NM_182757.3  

    Unigene Cluster for RNF144B:

    Ring finger protein 144B
    Hs.148741  [show with all ESTs]
    Unigene Representative Sequence: NM_182757
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000259939(uc003ncs.3) ENST00000486622 ENST00000429054
    miRNA
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    hsa-miR-3130-5p hsa-miR-607 hsa-miR-15a hsa-miR-4272 hsa-miR-503 hsa-miR-29a hsa-miR-342-3p hsa-miR-650
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    Additional mRNA sequence: 

    AB076367.1 AJ420555.1 AK096832.1 AK302935.1 AL832329.1 BC063311.1 

    7 DOTS entries:

    DT.101980491  DT.121306542  DT.121306560  DT.70100383  DT.121306550  DT.100033113  DT.65287839 

    Selected AceView cDNA sequences (see all 88):

    AI275691 BI492409 AW418836 CR593698 BI963694 T93777 AA912429 BU155788 
    AV720851 BG236189 CA313152 AW963235 BQ029385 BX366327 AI492918 AL575512 
    CB991565 AA233836 AW082966 BC063311 NM_182757 BI963946 BF038505 BE274992 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for RNF144B    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9
    SP1:                                      -                 -                                 
    SP2:                                      -                 -     -                           
    SP3:                                      -     -           -                                 
    SP4:                                      -                                                   
    SP5:                                                                                          


    ECgene alternative splicing isoforms for RNF144B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RNF144B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCATTTGAA
    RNF144B Expression
    About this image


    RNF144B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 5 entries
             Line H9 (Naive)
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Endochondral Facial Bones
     
     Testis (Reproductive System)
             Secondary Spermatocyte Seminiferous Tubules
     
     Endothelium (Cardiovascular System)
             Endothelial-like cells
     
     Gonad
             Secondary Spermatocyte Seminiferous Tubules
    RNF144B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RNF144B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.148741

    UniProtKB/Swiss-Prot: R144B_HUMAN, Q7Z419
    Tissue specificity: Broadly expressed, with lowest levels in brain and thymus, and highest levels detectable in
    heart, ovary and testis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including RNF144B: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF144B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RNF144B gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnf144b1 , 5 ring finger protein 144B1, 5 84.72(n)1
    88.37(a)1
      13 (24.50 cM)5
    2182151  NM_001170643.11  NP_001164114.11 
     471227205 
    chicken
    (Gallus gallus)
    Aves RNF144B1 ring finger protein 144B 76.16(n)
    79.8(a)
      420827  XM_004939623.1  XP_004939680.1 
    lizard
    (Anolis carolinensis)
    Reptilia RNF144B6
    ring finger protein 144B
    74(a)
    1 ↔ 1
    4(56749954-56810319)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia rnf144b1 ring finger 144B 72.52(n)
    72.19(a)
      100124330  NM_001113670.1  NP_001107142.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc639072 similar to IBR domain containing 2 75.93(n)   394112  BC053142.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG331446
    --
    13(a)
    1 → many
    2R(6627901-6681852)


    ENSEMBL Gene Tree for RNF144B (if available)
    TreeFam Gene Tree for RNF144B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RNF144B gene
    ANKIB12  ARIH12  ARIH22  RNF19B2  RNF144A2  RNF19A2  
    1 SIMAP similar gene for RNF144B using alignment to 2 protein entries:     R144B_HUMAN (see all proteins):
    RNF144A

    Find genes that share paralogs with RNF144B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RNF144B (see all 1920)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1475572351,2
    --18385591(+) ATTAAA/GTTTTG 1 -- us2k10--------
    rs574347981,2
    C,F--18385630(+) TGCATG/TGTTGA 1 -- us2k11Minor allele frequency- T:0.03EA 120
    rs1813722911,2
    --18385698(+) CTATTC/TGTGCT 1 -- us2k10--------
    rs1390966831,2
    C--18385702(+) TCGTG-/CTTATG 1 -- us2k10--------
    rs77481891,2
    C,F,A,H--18385889(+) TTCCTA/GTCCAC 1 -- us2k122Minor allele frequency- G:0.38NS EA NA WA CSA 2346
    rs737274291,2
    C,F--18386016(+) CTCATG/ATAACT 1 -- us2k12Minor allele frequency- A:0.11WA 120
    rs113937511,2
    C--18386101(+) TTTTT-/TGAGAC 1 -- us2k1 trp30--------
    rs1419835861,2
    --18386241(+) GATTAC/TAGGCA 1 -- us2k10--------
    rs1840518481,2
    --18386328(+) AACTCC/GTGACC 1 -- us2k10--------
    rs1148209451,2
    F--18386425(+) AATCAG/CGTTAT 1 -- us2k11Minor allele frequency- C:0.04NA 120

    HapMap Linkage Disequilibrium report for RNF144B (18368779 - 18469105 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for RNF144B (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2612022CNV Deletion19546169
    esv999347CNV Deletion20482838
    esv2731640CNV Deletion23290073
    esv3181CNV Deletion18987735
    nsv820580CNV Deletion20802225
    esv2467136CNV Deletion19546169
    esv2049444CNV Deletion18987734
    esv5916CNV Loss19470904
    nsv511853CNV Loss21212237
    nsv514344CNV Loss21397061

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RNF144B
    DNA2.0 Custom Variant and Variant Library Synthesis for RNF144B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with RNF144B           About GenesLikeMe

    Genetic Association Database (GAD): RNF144B
    Human Genome Epidemiology (HuGE) Navigator: RNF144B (1 document)

    Export disorders for RNF144B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RNF144B gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with RNF144B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The p53-inducible E3 ubiquitin ligase p53RFP induces p53-dependent apoptosis. (PubMed id 16427630)1, 2, 9 Huang J.... Shu H.-B. (FEBS Lett. 2006)
    2. p53RFP, a p53-inducible RING-finger protein, regulates the stability of p21WAF1. (PubMed id 12853982)1, 2, 9 Ng C.-C.... Nakamura Y. (Oncogene 2003)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. IBRDC2, an IBR-type E3 ubiquitin ligase, is a regulatory factor for Bax and apoptosis activation. (PubMed id 20300062)1, 2 Benard G....Karbowski M. (EMBO J. 2010)
    5. Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations. (PubMed id 18821565)1, 4 Lasky-Su J....Faraone S.V. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    9. Genome-wide association study link novel loci to endometriosis. (PubMed id 23472165)1 Albertsen H.M....Ward K. (PLoS ONE 2013)
    10. PIR2/Rnf144B regulates epithelial homeostasis by mediating degradation of p21WAF1 and p63. (PubMed id 23128396)1 Conforti F....Sayan B.S. (Oncogene 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 255488 HGNC: 21578 AceView: IBRDC2 Ensembl:ENSG00000137393 euGenes: HUgn255488
    ECgene: RNF144B H-InvDB: RNF144B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RNF144B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RNF144B gene:
    Search GeneIP for patents involving RNF144B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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