Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RNF144B Gene

protein-coding   GIFtS: 54
GCID: GC06P018368

ring finger protein 144B

(Previous name: IBR domain containing 2 )
(Previous symbol: IBRDC2)
 Explore 2 diseases affiliated with
RNF144B via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RNF144B    

Aliases
for RNF144B gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Ring Finger Protein 144B1 2 3     PIR22
IBRDC21 2 3     E3 Ubiquitin-Protein Ligase RNF144B2
BA528A10.31     P53RFP3
IBR Domain Containing 21 2     EC 6.3.2.-3
IBR Domain-Containing Protein 22 3     P53RFP3
P53-Inducible RING Finger Protein2 3     EC 6.3.28

External Ids:    HGNC: 215781   Entrez Gene: 2554882   Ensembl: ENSG000001373937   UniProtKB: Q7Z4193   

Export aliases for RNF144B gene to outside databases

Previous GC identifer: GC06P018496


Summaries
for RNF144B gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: R144B_HUMAN, Q7Z419
Function: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6
in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby
promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However,
its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein,
ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se




Genomic Views
for RNF144B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RNF144B gene promoter:
         COUP-TF1   STAT5B   MyoD   COUP   HNF-4alpha2   HNF-4alpha1   PPAR-gamma1   COUP-TF   PPAR-gamma2   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RNF144B promoter sequence
   Search SABiosciences Chromatin IP Primers for RNF144B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF144B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.3   Ensembl cytogenetic band:  6p22.3   HGNC cytogenetic band: 6p22.3

RNF144B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF144B gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P018368:  view genomic region     (about GC identifiers)

Start:
 18,368,779 bp from pter      End:
 18,469,105 bp from pter
Size:
 100,327 bases      Orientation:
 plus strand

Proteins
for RNF144B gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: R144B_HUMAN, Q7Z419 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase RNF144B  
Size: 303 amino acids; 33697 Da
Subunit: Interacts with UBE2L3, UBE2L6 and LCMT2, as well as with BAX
Subcellular location: Mitochondrion membrane; Single-pass membrane protein. Cytoplasm. Note=Mostly cytosololic,
accumulates in submitochondrial domains specifically upon apoptosis induction, in synchrony with BAX activation
Caution: Lacks the His residue in the RING-type domain 2 that is one of the conserved features of the family
Sequence caution: Sequence=CAD38622.1; Type=Erroneous initiation;
Secondary accessions: B3KUA8 Q5TB85 Q6P4Q0 Q8N3R7 Q9BX38

Explore the universe of human proteins at neXtProt for RNF144B: NX_Q7Z419

Post-translational modifications:

  • Auto-ubiquitinated1
  • View neXtProt modification sites for NX_Q7Z419

    • 2 DME Specific Peptides for RNF144B (Q7Z419)
     EGCAQMMCKNCKH  GPCRNKLGHSRASV 

    RNF144B Protein expression data from MOPED and PaxDb:    About this image 
    RNF144B Protein Expression
    REFSEQ proteins: NP_877434.2  
    ENSEMBL proteins: 
     ENSP00000259939   ENSP00000411270  
    Reactome Protein details: Q7Z419
    Human Recombinant Protein Products for RNF144B: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: RNF144B
    OriGene Custom Protein Services for RNF144B 
    GenScript Custom Purified and Recombinant Proteins Services for RNF144B
    Novus Biologicals RNF144B Proteins
    Novus Biologicals RNF144B Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for RNF144B

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex IC12853982
    GO:0005737cytoplasm IDA--
    GO:0016021integral to membrane IEA--
    GO:0031966mitochondrial membrane IDA--

    RNF144B for ontologies           About GeneDecksing



    RNF144B Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies (see all 12): RNF144B
    OriGene Custom Antibody Services for RNF144B 
    GenScript Custom Superior Antibodies Services for RNF144B
    Novus Biologicals RNF144B Antibodies
    Abcam antibodies for RNF144B 
    Uscn Antibodies for RNF144B
    Search ThermoFisher Antibodies for RNF144B

    Assay Products for RNF144B: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RNF144B
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for RNF144B

    Protein Domains /
    Families
    for RNF144B gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RNF144B for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR017907 Znf_RING_CS
     IPR002867 Znf_C6HC
     IPR001841 Znf_RING

    Graphical View of Domain Structure for InterPro Entry Q7Z419

    ProtoNet protein and cluster: Q7Z419

    2 Blocks protein families:
    IPB001841 Zn-finger
    IPB002867 Zn-finger


    UniProtKB/Swiss-Prot: R144B_HUMAN, Q7Z419
    Domain: The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme (By similarity). The
    transmembrane domain is essential for translocation to the mitochondria upon induction of apoptosis
    Similarity: Belongs to the RBR family. RNF144 subfamily
    Similarity: Contains 1 IBR-type zinc finger
    Similarity: Contains 2 RING-type zinc fingers


    Function
    for RNF144B gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: R144B_HUMAN, Q7Z419
    Function: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6
    in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby
    promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However,
    its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein,
    ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se

         Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IDA12853982
    GO:0005515protein binding IPI--
    GO:0008270zinc ion binding IEA--
    GO:0016874ligase activity ----
         
    RNF144B for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for RNF144B:
     Increased G1 DNA content  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for RNF144B 

    miRNA
    Products:            		 OriGene 3'-UTR Clone: RNF144B
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RNF144B
    8/57 QIAGEN miScript miRNA Assays for microRNAs that regulate RNF144B (see all 57):
    hsa-miR-3130-5p hsa-miR-607 hsa-miR-15a hsa-miR-4272 hsa-miR-503 hsa-miR-29a hsa-miR-342-3p hsa-miR-650
    SwitchGear 3'UTR luciferase reporter plasmid: RNF144B 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RNF144B (see all 4)
    OriGene shRNA RFP: RNF144B
    OriGene siRNA: RNF144B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNF144B
    Sirion Biotech Custom design and validation of potent shRNA sequences against RNF144B 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for RNF144B
    Sirion Biotech Customized adenovirus for overexpression of RNF144B 
    Sirion Biotech Customized adenovirus for potent knockdown of RNF144B

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF144B (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF144B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: RNF144B (NM_182757)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNF144B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF144B 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for RNF144B
    Search LifeMap BioReagents cell lines for RNF144B
    Sirion Biotech Customized stable knockdown cell line services for RNF144B 
    Sirion Biotech Customized inducible knockdown cell line services for RNF144B
    Sirion Biotech Customized stable overexpressing cell line services for RNF144B
    Sirion Biotech Customized inducible overexpressing cell line services for RNF144B

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF144B


    Pathways & Interactions
    for RNF144B gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Antigen processing: Ubiquitination & Proteasome degradation
    		Antigen processing: Ubiquitination & Proteasome degradation1.00
    		Polyubiquitination of substrate0.75
    		Class I MHC mediated antigen processing & presentation0.83
    2Immune System
    		Immune System1.00
    		Adaptive Immune System0.59
    3Direct p53 effectors
    		Direct p53 effectors1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for RNF144B 
        Direct p53 effectors

    5        Reactome Pathways for RNF144B
        Antigen processing: Ubiquitination & Proteasome degradation
    Polyubiquitination of substrate
    Adaptive Immune System
    Class I MHC mediated antigen processing & presentation
    Immune System


    UniProtKB/Swiss-Prot: R144B_HUMAN, Q7Z419
    Pathway: Protein modification; protein ubiquitination


    RNF144B for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNF144B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/14 Interacting proteins for RNF144B (Q7Z4192, 3 ENSP000002599394) via UniProtKB, MINT, STRING, and/or I2D (see all 14)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    BAXQ078122, 3, ENSP000002932884MINT-7948862 MINT-7949239 MINT-7949262 MINT-7948774 MINT-7949221 I2D: score=2 STRING: ENSP00000293288
    TOMM20Q153882, 3, ENSP000003555664MINT-7945209 MINT-7945674 MINT-7949017 I2D: score=1 STRING: ENSP00000355566
    UBE2L6O149332, 3, ENSP000002871564MINT-1771917 MINT-1771944 I2D: score=4 STRING: ENSP00000287156
    CYCSP999992, 3, ENSP000003077864MINT-7944749 MINT-7949203 I2D: score=1 STRING: ENSP00000307786
    UBE2IP632793, ENSP000003248974I2D: score=2 STRING: ENSP00000324897
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0042787protein ubiquitination involved in ubiquitin-dependent protein catabolic process IDA12853982
    GO:0045768positive regulation of anti-apoptosis ----

    RNF144B for ontologies           About GeneDecksing



    Drugs & Compounds
    for RNF144B gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RNF144B

    4 HMDB Compounds for RNF144B    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--
    Search CenterWatch for drugs/clinical trials and news about RNF144B / R144B 

    Transcripts
    for RNF144B gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RNF144B gene: 
    NM_182757.3  

    Unigene Cluster for RNF144B:

    Ring finger protein 144B
    Hs.148741  [show with all ESTs]
    Unigene Representative Sequence: NM_182757
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000259939(uc003ncs.3) ENST00000486622 ENST00000429054

    miRNA
    Products:             		 OriGene 3'-UTR Clone: RNF144B
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RNF144B
    8/57 QIAGEN miScript miRNA Assays for microRNAs that regulate RNF144B (see all 57):
    hsa-miR-3130-5p hsa-miR-607 hsa-miR-15a hsa-miR-4272 hsa-miR-503 hsa-miR-29a hsa-miR-342-3p hsa-miR-650
    SwitchGear 3'UTR luciferase reporter plasmid: RNF144B 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RNF144B (see all 4)
    OriGene shRNA RFP: RNF144B
    OriGene siRNA: RNF144B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNF144B
    Sirion Biotech Custom design and validation of potent shRNA sequences against RNF144B 
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF144B (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF144B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: RNF144B (NM_182757)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNF144B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF144B 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNF144B
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RNF144B
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNF144B
      Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNF144B

    Additional cDNA sequence: 

    AB076367.1 AJ420555.1 AK096832.1 AK302935.1 AL832329.1 BC063311.1 

    7 DOTS entries:

    DT.101980491  DT.121306542  DT.121306560  DT.70100383  DT.121306550  DT.100033113  DT.65287839 

    24/88 AceView cDNA sequences (see all 88):

    BG236189 CA313152 AA912429 BI492409 AI275691 BU155788 BI963694 T93777 
    CR593698 AW418836 AV720851 NM_182757 BX089268 BQ029385 BQ006567 AI953847 
    CB991565 BX348918 AI523107 BI963946 AB076367 AI431798 AW082966 AV724327 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for RNF144B    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9
    SP1:                                      -                 -                                 
    SP2:                                      -                 -     -                           
    SP3:                                      -     -           -                                 
    SP4:                                      -                                                   
    SP5:                                                                                          


    ECgene alternative splicing isoforms for RNF144B

    Expression
    for RNF144B gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RNF144B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTCATTTGAA
    RNF144B Expression
    About this image

    RNF144B expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    TestisSeminiferous TubulesSecondary SpermatocyteGerm Cells, Male Gametocytes
    BoneEndochondral Facial BonesBone
    BoneRostral Skull Membranous BonesBone
    EyeRetinaEye
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 6 LifeMap Cells 
    NameCategory
    PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)Endothelium
    PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)Intermediate Mesoderm, Kidney
    PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)Endothelium
    Line H9 (WA09) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Blimp1- mVenus and stella-ECFP genetically modified stem cells (Embryonic Stem Cell)Early Embryo, Inner Cell Mass

    See RNF144B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RNF144B

    SOURCE GeneReport for Unigene cluster: Hs.148741

    UniProtKB/Swiss-Prot: R144B_HUMAN, Q7Z419
    Tissue specificity: Broadly expressed, with lowest levels in brain and thymus, and highest levels detectable in heart,
    ovary and testis

        SABiosciences Expression via Pathway-Focused PCR Arrays including RNF144B: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNF144B
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RNF144B
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNF144B
    Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNF144B
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF144B

    Orthologs
    for RNF144B gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RNF144B gene from 5/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves RNF144B1 ring finger protein 144B 76.38(n)
    79.8(a)    		   420827  XM_418918.3  XP_418918.3 
    lizard
    (Anolis carolinensis)    		 Reptilia RNF144B6
    		 --
    		 77(a)
    		 1 ↔ 1
    		 4(56753048-56784864)
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc639072 similar to IBR domain containing 2 75.93(n)   394112  BC053142.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG331446
    		 --
    		 13(a)
    		 1 → many
    		 2R(6627901-6681852)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 RWD domain containing protein, expressed
    		 6(a)
    		 possible ortholog
    		 4(29826986-29831282)


    ENSEMBL Gene Tree for RNF144B (if available)
    TreeFam Gene Tree for RNF144B (if available) 

    Paralogs
    for RNF144B gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RNF144B gene
    RNF142  RNF19B2  RNF144A2  RNF2172  RNF19A2  
    1 SIMAP similar gene for RNF144B using alignment to 2 protein entries:     R144B_HUMAN (see all proteins):
    RNF144A

    RNF144B for paralogs           About GeneDecksing



    Genomic Variants
    for RNF144B gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1689 NCBI SNPs in RNF144B are shown (see all 1689)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1475572351,2
    		--18385591(+) ATTAAA/GTTTTG 1 -- us2k10--------
    rs574347981,2
    		F--18385630(+) TGCATG/TGTTGA 1 -- us2k11Minor allele frequency- T:0.03EA 120
    rs1813722911,2
    		--18385698(+) CTATTC/TGTGCT 1 -- us2k10--------
    rs1390966831,2
    		--18385702(+) TCGTG-/CTTATG 1 -- us2k10--------
    rs77481891,2
    		C,F,A,H--18385889(+) TTCCTA/GTCCAC 1 -- us2k122Minor allele frequency- G:0.38NS EA NA WA CSA 2346
    rs737274291,2
    		C--18386016(+) CTCATG/ATAACT 1 -- us2k12Minor allele frequency- A:0.11WA 120
    rs1419835861,2
    		--18386241(+) GATTAC/TAGGCA 1 -- us2k10--------
    rs1840518481,2
    		--18386328(+) AACTCC/GTGACC 1 -- us2k10--------
    rs1148209451,2
    		F--18386425(+) AATCAG/CGTTAT 1 -- us2k11Minor allele frequency- C:0.04NA 120
    rs715561731,2
    		C,F--18386475(+) CCTACC/TGTGGG 1 -- us2k14Minor allele frequency- T:0.08NA WA 242

    HapMap Linkage Disequilibrium report for RNF144B (18368779 - 18469105 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 12 variations for RNF144B
         4 CNVs: 43222 99444 62478 99445
         8 Indels: 59312 81248 47077 93515 64443 93516 40837 93514

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNF144B
    DNA2.0 Custom Variant and Variant Library Synthesis for RNF144B

    Disorders / Diseases
    for RNF144B gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RNF144B for disorders           About GeneDecksing

    2 diseases for RNF144B:    About MalaCards
    attention deficit hyperactivity disorder    malaria

    Human Genome Epidemiology (HuGE) Navigator: RNF144B (1 document)

    Export disorders for RNF144B gene to outside databases

    Publications
    for RNF144B gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RNF144B gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with RNF144B)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The p53-inducible E3 ubiquitin ligase p53RFP induces p53-dependent apoptosis. (PubMed id 16427630)1, 2, 9 Huang J.... Shu H.-B. (2006)
    2. p53RFP, a p53-inducible RING-finger protein, regulates the stability of p21WAF1. (PubMed id 12853982)1, 2, 9 Ng C.-C.... Nakamura Y. (2003)
    3. IBRDC2, an IBR-type E3 ubiquitin ligase, is a regulat ory factor for Bax and apoptosis activation. (PubMed id 20300062)1, 2 Benard G....Karbowski M. (2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    7. Systematic analysis of dimeric E3-RING interactions re veals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)1 Woodsmith J....Sanderson C.M. (2012)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    9. Differential control of TAp73 and DeltaNp73 protein s tability by the ring finger ubiquitin ligase PIR2. (PubMed id 20615966)1 Sayan B.S....Melino G. (2010)
    10. Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. (PubMed id 19549727)1 Markson G....Sanderson C.M. (2009)

    External Searches for RNF144B gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing RNF144B gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 255488 HGNC: 21578 AceView: IBRDC2 Ensembl:ENSG00000137393 euGenes: HUgn255488
    ECgene: RNF144B H-InvDB: RNF144B

    Other Databases showing RNF144B gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RNF144B gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RNF144B Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for RNF144B gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RNF144B gene:
    Search GeneIP for patents involving RNF144B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for RNF144B gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for RNF144B   OriGene shRNA RFP for RNF144B  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RNF144B   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNF144B  
     OriGene Protein Over-expression Lysate for RNF144B   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for RNF144B   OriGene 3'-UTR Clone for RNF144B  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF144B   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF144B  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RNF144B   OriGene Custom Protein Services for RNF144B  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RNF144B
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNF144B
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF144B
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNF144B
     Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNF144B
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNF144B
     GenScript Custom Purified and Recombinant Proteins Services for RNF144B GenScript cDNA clones with any tag delivered in your preferred vector for RNF144B
     GenScript Custom Assay Services for RNF144B GenScript Custom Superior Antibodies Services for RNF144B
     GenScript Custom overexpressing Cell Line Services for RNF144B CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in RNF144B promoter
     Search Chromatin IP Primers for RNF144B
     RT2 qPCR Primer Assay in human, mouse, rat RNF144B
     Search GNC Networks for RNF144B
     SABiosciences PCR Arrays including human, mouse, rat RNF144B
     Search Tocris compounds for RNF144B
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     RNF144B antibodies
     RNF144B proteins
     RNF144B lysates
     Antibodies for RNF144B
     See all of Abcam's Antibodies, Kits and Proteins for RNF144B
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     RNF144B Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for RNF144B
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF144B
     SwitchGear 3'UTR luciferase reporter plasmids for RNF144B
     SwitchGear Promoter luciferase reporter plasmids for RNF144B
     Search ThermoFisher Antibodies for RNF144B
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF144B
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for RNF144B
    Sirion Biotech Customized:
     stable knockdown cell line services for RNF144B
     inducible knockdown cell line services for RNF144B
     design and validation of potent shRNA sequences against RNF144B
     adenovirus for potent knockdown of RNF144B
     adenovirus for overexpression of RNF144B
     stable overexpressing cell line services for RNF144B
     inducible overexpressing cell line services for RNF144B
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      RNF144B gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4