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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RNF144B Gene

protein-coding   GIFtS: 55
GCID: GC06P018368

Ring Finger Protein 144B

(Previous name: IBR domain containing 2)
(Previous symbol: IBRDC2)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ring Finger Protein 144B1 2 3     bA528A10.32
IBRDC21 2 3     E3 Ubiquitin-Protein Ligase RNF144B2
IBR Domain Containing 21 2     p53RFP2
IBR Domain-Containing Protein 22 3     EC 6.3.2.-3
P53-Inducible RING Finger Protein2 3     P53RFP3
PIR22     EC 6.3.28

External Ids:    HGNC: 215781   Entrez Gene: 2554882   Ensembl: ENSG000001373937   UniProtKB: Q7Z4193   

Export aliases for RNF144B gene to outside databases

Previous GC identifer: GC06P018496


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RNF144B Gene: 
RNF144B (ring finger protein 144B) is a protein-coding gene. Diseases associated with RNF144B include attention deficit hyperactivity disorder, and among its related super-pathways are Class I MHC mediated antigen processing & presentation and Immune System. GO annotations related to this gene include ubiquitin-protein ligase activity and zinc ion binding. An important paralog of this gene is RNF14.

UniProtKB/Swiss-Prot: R144B_HUMAN, Q7Z419
Function: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and
UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2,
thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent
mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a
pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein
per se




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RNF144B gene promoter:
         COUP-TF1   STAT5B   MyoD   COUP   HNF-4alpha2   HNF-4alpha1   PPAR-gamma1   COUP-TF   PPAR-gamma2   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNF144B promoter sequence
   Search SABiosciences Chromatin IP Primers for RNF144B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF144B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.3   Ensembl cytogenetic band:  6p22.3   HGNC cytogenetic band: 6p22.3

RNF144B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF144B gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P018368:  view genomic region     (about GC identifiers)

Start:
18,368,779 bp from pter      End:
18,469,105 bp from pter
Size:
100,327 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: R144B_HUMAN, Q7Z419 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase RNF144B  
Size: 303 amino acids; 33697 Da
Subunit: Interacts with UBE2L3, UBE2L6 and LCMT2, as well as with BAX
Subcellular location: Mitochondrion membrane; Single-pass membrane protein. Cytoplasm. Note=Mostly cytosololic,
accumulates in submitochondrial domains specifically upon apoptosis induction, in synchrony with BAX activation
Caution: Lacks the His residue in the RING-type domain 2 that is one of the conserved features of the family
Sequence caution: Sequence=CAD38622.1; Type=Erroneous initiation;
Secondary accessions: B3KUA8 Q5TB85 Q6P4Q0 Q8N3R7 Q9BX38

Explore the universe of human proteins at neXtProt for RNF144B: NX_Q7Z419

Explore proteomics data for RNF144B at MOPED 

Post-translational modifications:

  • UniProtKB: Auto-ubiquitinated
  • View neXtProt modification sites for NX_Q7Z419

  • 2 DME Specific Peptides for RNF144B (Q7Z419)
     EGCAQMMCKNCKH  GPCRNKLGHSRASV 

    RNF144B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RNF144B Protein Expression
    REFSEQ proteins: NP_877434.2  
    ENSEMBL proteins: 
     ENSP00000259939   ENSP00000411270  
    Reactome Protein details: Q7Z419
    Human Recombinant Protein Products for RNF144B: 
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    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex IC12853982
    GO:0005737cytoplasm IDA--
    GO:0016021integral to membrane IEA--
    GO:0031966mitochondrial membrane IDA--

    RNF144B for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RNF: RING-type (C3HC4) zinc fingers

    3 InterPro protein domains:
     IPR017907 Znf_RING_CS
     IPR002867 Znf_C6HC
     IPR001841 Znf_RING

    Graphical View of Domain Structure for InterPro Entry Q7Z419

    ProtoNet protein and cluster: Q7Z419

    2 Blocks protein domains:
    IPB001841 Zn-finger
    IPB002867 Zn-finger


    UniProtKB/Swiss-Prot: R144B_HUMAN, Q7Z419
    Domain: The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme (By similarity).
    The transmembrane domain is essential for translocation to the mitochondria upon induction of apoptosis
    Similarity: Belongs to the RBR family. RNF144 subfamily
    Similarity: Contains 1 IBR-type zinc finger
    Similarity: Contains 2 RING-type zinc fingers


    RNF144B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: R144B_HUMAN, Q7Z419
    Function: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and
    UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2,
    thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent
    mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a
    pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein
    per se

         Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IDA12853982
    GO:0005515protein binding IPI12853982
    GO:0008270zinc ion binding IEA--
    GO:0016874ligase activity ----
         
    RNF144B for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for RNF144B:
     Increased G1 DNA content  Increased gamma-H2AX phosphory 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RNF144B About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Antigen processing: Ubiquitination & Proteasome degradation
    Antigen processing: Ubiquitination & Proteasome degradation0.83
    Class I MHC mediated antigen processing & presentation0.83
    2Immune System
    Immune System0.56
    Adaptive Immune System0.56
    3Gastric cancer network 2
    Gastric cancer network 2
    4Direct p53 effectors
    Direct p53 effectors

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for RNF144B
        Gastric cancer network 2
    Direct p53 effectors


    4        Reactome Pathways for RNF144B
        Antigen processing: Ubiquitination & Proteasome degradation
    Adaptive Immune System
    Class I MHC mediated antigen processing & presentation
    Immune System


    UniProtKB/Swiss-Prot: R144B_HUMAN, Q7Z419
    Pathway: Protein modification; protein ubiquitination


    RNF144B for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNF144B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/14 Interacting proteins for RNF144B (Q7Z4192, 3 ENSP000002599394) via UniProtKB, MINT, STRING, and/or I2D (see all 14)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    BAXQ078122, 3, ENSP000002932884MINT-7948862 MINT-7949239 MINT-7949262 MINT-7948774 MINT-7949221 I2D: score=2 STRING: ENSP00000293288
    TOMM20Q153882, 3, ENSP000003555664MINT-7945209 MINT-7945674 MINT-7949017 I2D: score=1 STRING: ENSP00000355566
    UBE2L6O149332, 3, ENSP000002871564MINT-1771917 MINT-1771944 I2D: score=4 STRING: ENSP00000287156
    CYCSP999992, 3, ENSP000003077864MINT-7944749 MINT-7949203 I2D: score=1 STRING: ENSP00000307786
    UBE2IP632793, ENSP000003248974I2D: score=2 STRING: ENSP00000324897
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0042787protein ubiquitination involved in ubiquitin-dependent protein catabolic process IDA12853982

    RNF144B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RNF144B (R144B)

    4 HMDB Compounds for RNF144B    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    Search CenterWatch for drugs/clinical trials and news about RNF144B / R144B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RNF144B gene: 
    NM_182757.3  

    Unigene Cluster for RNF144B:

    Ring finger protein 144B
    Hs.148741  [show with all ESTs]
    Unigene Representative Sequence: NM_182757
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000259939(uc003ncs.3) ENST00000486622 ENST00000429054
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    Additional mRNA sequence: 

    AB076367.1 AJ420555.1 AK096832.1 AK302935.1 AL832329.1 BC063311.1 

    7 DOTS entries:

    DT.101980491  DT.121306542  DT.121306560  DT.70100383  DT.121306550  DT.100033113  DT.65287839 

    24/88 AceView cDNA sequences (see all 88):

    AV720851 BU155788 T93777 CA313152 BI963694 CR593698 BG236189 AI275691 
    AW418836 BI492409 AA912429 BX366327 AI523107 BE274992 AW188022 AI784430 
    AJ420555 CK903664 AV724327 BQ029385 BI963830 AI581733 AA233836 AA776593 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for RNF144B    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9
    SP1:                                      -                 -                                 
    SP2:                                      -                 -     -                           
    SP3:                                      -     -           -                                 
    SP4:                                      -                                                   
    SP5:                                                                                          


    ECgene alternative splicing isoforms for RNF144B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RNF144B expression in normal human tissues (normalized intensities)      RNF144B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCATTTGAA
    RNF144B Expression
    About this image


    RNF144B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/18 selected tissues (see all 18) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 13 entries
             Endothelial-like cells ( Derivation and purification of endothelial precursor cells...
             Human Cardiac Microvascular Endothelial Cells (HCMEC)   
     
     Bone (Muscoskeletal System)    fully expand to see all 5 entries
             Endochondral Facial Bones
             skeleton/cranium/chondrocranium   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 4 entries
             fetal cartilage   
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 3 entries
             skeleton/cranium/chondrocranium   
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 2 entries
             Human Bladder Microvascular Endothelial Cells (HBdMEC)   
             visceral organ/bladder/urothelium of bladder   

    See RNF144B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RNF144B

    SOURCE GeneReport for Unigene cluster: Hs.148741

    UniProtKB/Swiss-Prot: R144B_HUMAN, Q7Z419
    Tissue specificity: Broadly expressed, with lowest levels in brain and thymus, and highest levels detectable in
    heart, ovary and testis

        SABiosciences Expression via Pathway-Focused PCR Arrays including RNF144B: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RNF144B gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnf144b1 , 5 ring finger protein 144B1, 5 84.72(n)1
    88.37(a)1
      13 (24.50 cM)5
    2182151  NM_001170643.11  NP_001164114.11 
     471227205 
    chicken
    (Gallus gallus)
    Aves RNF144B1 ring finger protein 144B 76.38(n)
    79.8(a)
      420827  XM_418918.3  XP_418918.3 
    lizard
    (Anolis carolinensis)
    Reptilia RNF144B6
    Uncharacterized protein
    74(a)
    1 ↔ 1
    4(56749954-56810319)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc639072 similar to IBR domain containing 2 75.93(n)   394112  BC053142.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG331446
    --
    13(a)
    1 → many
    2R(6627901-6681852)


    ENSEMBL Gene Tree for RNF144B (if available)
    TreeFam Gene Tree for RNF144B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RNF144B gene
    RNF142  RNF19B2  RNF144A2  RNF19A2  
    1 SIMAP similar gene for RNF144B using alignment to 2 protein entries:     R144B_HUMAN (see all proteins):
    RNF144A

    RNF144B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1920 SNPs in RNF144B are shown (see all 1920)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1475572351,2
    --18385591(+) ATTAAA/GTTTTG 1 -- us2k10--------
    rs574347981,2
    C,F--18385630(+) TGCATG/TGTTGA 1 -- us2k11Minor allele frequency- T:0.03EA 120
    rs1813722911,2
    --18385698(+) CTATTC/TGTGCT 1 -- us2k10--------
    rs1390966831,2
    C--18385702(+) TCGTG-/CTTATG 1 -- us2k10--------
    rs77481891,2
    C,F,A,H--18385889(+) TTCCTA/GTCCAC 1 -- us2k122Minor allele frequency- G:0.38NS EA NA WA CSA 2346
    rs737274291,2
    C,F--18386016(+) CTCATG/ATAACT 1 -- us2k12Minor allele frequency- A:0.11WA 120
    rs113937511,2
    C--18386101(+) TTTTT-/TGAGAC 1 -- us2k1 trp30--------
    rs1419835861,2
    --18386241(+) GATTAC/TAGGCA 1 -- us2k10--------
    rs1840518481,2
    --18386328(+) AACTCC/GTGACC 1 -- us2k10--------
    rs1148209451,2
    F--18386425(+) AATCAG/CGTTAT 1 -- us2k11Minor allele frequency- C:0.04NA 120

    HapMap Linkage Disequilibrium report for RNF144B (18368779 - 18469105 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/12 variations for RNF144B (see all 12):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2612022CNV Deletion19546169
    esv999347CNV Deletion20482838
    esv2731640CNV Deletion23290073
    esv3181CNV Deletion18987735
    nsv820580CNV Deletion20802225
    esv2467136CNV Deletion19546169
    esv2049444CNV Deletion18987734
    esv5916CNV Loss19470904
    nsv511853CNV Loss21212237
    nsv514344CNV Loss21397061

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for RNF144B:    About MalaCards
    attention deficit hyperactivity disorder    


    RNF144B for disorders           About GeneDecksing

    Genetic Association Database (GAD): RNF144B
    Human Genome Epidemiology (HuGE) Navigator: RNF144B (1 document)

    Export disorders for RNF144B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RNF144B gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with RNF144B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The p53-inducible E3 ubiquitin ligase p53RFP induces p53-dependent apoptosis. (PubMed id 16427630)1, 2, 9 Huang J.... Shu H.-B. (2006)
    2. p53RFP, a p53-inducible RING-finger protein, regulates the stability of p21WAF1. (PubMed id 12853982)1, 2, 9 Ng C.-C.... Nakamura Y. (2003)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. IBRDC2, an IBR-type E3 ubiquitin ligase, is a regulat ory factor for Bax and apoptosis activation. (PubMed id 20300062)1, 2 Benard G....Karbowski M. (2010)
    5. Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations. (PubMed id 18821565)1, 4 Lasky-Su J....Faraone S.V. (2008)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    9. Genome-wide association study link novel loci to endom etriosis. (PubMed id 23472165)1 Albertsen H.M....Ward K. (2013)
    10. Direct and indirect control of mitogen-activated prote in kinase pathway-associated components, BRAP/IMP E3 ubiquitin ligase and CRAF/R AF1 kinase, by the deubiquitylating enzyme USP15. (PubMed id 23105109)1 Hayes S.D....Urbe S. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 255488 HGNC: 21578 AceView: IBRDC2 Ensembl:ENSG00000137393 euGenes: HUgn255488
    ECgene: RNF144B H-InvDB: RNF144B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RNF144B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RNF144B gene:
    Search GeneIP for patents involving RNF144B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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