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Aliases for RNF144B Gene

Aliases for RNF144B Gene

  • Ring Finger Protein 144B 2 3
  • P53-Inducible RING Finger Protein 3 4
  • IBR Domain-Containing Protein 2 3 4
  • RING Finger Protein 144B 4 5
  • IBR Domain Containing 2 2 3
  • P53RFP 3 4
  • IBRDC2 3 4
  • BA528A10.3 3
  • EC 6.3.2.- 4
  • EC 6.3.2 63
  • PIR2 3

External Ids for RNF144B Gene

Previous HGNC Symbols for RNF144B Gene

  • IBRDC2

Previous GeneCards Identifiers for RNF144B Gene

  • GC06P018496
  • GC06P018368

Summaries for RNF144B Gene

GeneCards Summary for RNF144B Gene

RNF144B (Ring Finger Protein 144B) is a Protein Coding gene. Among its related pathways are Immune System and Direct p53 effectors. GO annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is RNF19A.

UniProtKB/Swiss-Prot for RNF144B Gene

  • E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF144B Gene

Genomics for RNF144B Gene

Regulatory Elements for RNF144B Gene

Genomic Location for RNF144B Gene

Chromosome:
6
Start:
18,277,515 bp from pter
End:
18,468,874 bp from pter
Size:
191,360 bases
Orientation:
Plus strand

Genomic View for RNF144B Gene

Genes around RNF144B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF144B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF144B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF144B Gene

Proteins for RNF144B Gene

  • Protein details for RNF144B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z419-R144B_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase RNF144B
    Protein Accession:
    Q7Z419
    Secondary Accessions:
    • B3KUA8
    • B4DZI2
    • Q5TB85
    • Q6P4Q0
    • Q8N3R7
    • Q9BX38

    Protein attributes for RNF144B Gene

    Size:
    303 amino acids
    Molecular mass:
    33697 Da
    Quaternary structure:
    • Interacts with UBE2L3, UBE2L6 and LCMT2, as well as with BAX.
    SequenceCaution:
    • Sequence=CAD38622.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RNF144B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNF144B Gene

Proteomics data for RNF144B Gene at MOPED

Selected DME Specific Peptides for RNF144B Gene

Post-translational modifications for RNF144B Gene

Other Protein References for RNF144B Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for RNF144B Gene

Gene Families for RNF144B Gene

Protein Domains for RNF144B Gene

Suggested Antigen Peptide Sequences for RNF144B Gene

Graphical View of Domain Structure for InterPro Entry

Q7Z419

UniProtKB/Swiss-Prot:

R144B_HUMAN :
  • The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme (By similarity). The transmembrane domain is essential for translocation to the mitochondria upon induction of apoptosis.
  • Belongs to the RBR family. RNF144 subfamily.
  • Contains 1 IBR-type zinc finger.
Domain:
  • The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme (By similarity). The transmembrane domain is essential for translocation to the mitochondria upon induction of apoptosis.
Family:
  • Belongs to the RBR family. RNF144 subfamily.
Similarity:
  • Contains 1 IBR-type zinc finger.
  • Contains 2 RING-type zinc fingers.
genes like me logo Genes that share domains with RNF144B: view

Function for RNF144B Gene

Molecular function for RNF144B Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se.

Enzyme Numbers (IUBMB) for RNF144B Gene

Gene Ontology (GO) - Molecular Function for RNF144B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 12853982
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with RNF144B: view
genes like me logo Genes that share phenotypes with RNF144B: view

Animal Models for RNF144B Gene

MGI Knock Outs for RNF144B:

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RNF144B Gene

Localization for RNF144B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF144B Gene

Mitochondrion membrane; Single-pass membrane protein. Cytoplasm. Note=Mostly cytosololic, accumulates in submitochondrial domains specifically upon apoptosis induction, in synchrony with BAX activation.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNF144B Gene COMPARTMENTS Subcellular localization image for RNF144B gene
Compartment Confidence
mitochondrion 5
nucleus 3
plasma membrane 3

Gene Ontology (GO) - Cellular Components for RNF144B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with RNF144B: view

Pathways & Interactions for RNF144B Gene

genes like me logo Genes that share pathways with RNF144B: view

UniProtKB/Swiss-Prot Q7Z419-R144B_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for RNF144B Gene

None

No data available for SIGNOR curated interactions for RNF144B Gene

Drugs & Compounds for RNF144B Gene

(3) Drugs for RNF144B Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Diphosphate Experimental Pharma 0

(1) Additional Compounds for RNF144B Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
genes like me logo Genes that share compounds with RNF144B: view

Transcripts for RNF144B Gene

mRNA/cDNA for RNF144B Gene

Unigene Clusters for RNF144B Gene

Ring finger protein 144B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF144B Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9
SP1: - -
SP2: - - -
SP3: - - -
SP4: -
SP5:

Relevant External Links for RNF144B Gene

GeneLoc Exon Structure for
RNF144B
ECgene alternative splicing isoforms for
RNF144B

Expression for RNF144B Gene

mRNA expression in normal human tissues for RNF144B Gene

mRNA differential expression in normal tissues according to GTEx for RNF144B Gene

This gene is overexpressed in Whole Blood (x6.9).

SOURCE GeneReport for Unigene cluster for RNF144B Gene Hs.148741

mRNA Expression by UniProt/SwissProt for RNF144B Gene

Q7Z419-R144B_HUMAN
Tissue specificity: Broadly expressed, with lowest levels in brain and thymus, and highest levels detectable in heart, ovary and testis.
genes like me logo Genes that share expression patterns with RNF144B: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for RNF144B Gene

Orthologs for RNF144B Gene

This gene was present in the common ancestor of animals.

Orthologs for RNF144B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RNF144B 35
  • 89.66 (n)
  • 94.39 (a)
RNF144B 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNF144B 35
  • 90.76 (n)
  • 95.38 (a)
RNF144B 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnf144b 35
  • 84.72 (n)
  • 88.37 (a)
Rnf144b 16
Rnf144b 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RNF144B 35
  • 99.56 (n)
  • 100 (a)
RNF144B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnf144b 35
  • 84.5 (n)
  • 88.37 (a)
oppossum
(Monodelphis domestica)
Mammalia RNF144B 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RNF144B 36
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves RNF144B 35
  • 76.16 (n)
  • 79.8 (a)
RNF144B 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RNF144B 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf144b 35
  • 72.52 (n)
  • 72.19 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc63907 35
zgc:63907 35
  • 63.95 (n)
  • 65.93 (a)
RNF144B 36
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG33144 36
  • 13 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.606 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3687 36
  • 33 (a)
OneToMany
Species with no ortholog for RNF144B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF144B Gene

ENSEMBL:
Gene Tree for RNF144B (if available)
TreeFam:
Gene Tree for RNF144B (if available)

Paralogs for RNF144B Gene

Paralogs for RNF144B Gene

(1) SIMAP similar genes for RNF144B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RNF144B: view

Variants for RNF144B Gene

Sequence variations from dbSNP and Humsavar for RNF144B Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs214527 -- 18,291,119(-) AAGAT(A/G/T)GTATT intron-variant
rs214528 -- 18,291,043(-) GCGGT(A/G)GGGAG intron-variant
rs214529 -- 18,290,675(-) CGACA(A/G)AGCGA intron-variant
rs214530 -- 18,290,549(-) CCCAC(C/T)CTCAT intron-variant
rs214531 -- 18,289,891(-) TTACA(A/T)GTGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNF144B Gene

Variant ID Type Subtype PubMed ID
nsv511853 CNV Loss 21212237
esv2467136 CNV Deletion 19546169
esv2049444 CNV Deletion 18987734
esv3181 CNV Deletion 18987735
esv2731640 CNV Deletion 23290073
esv999347 CNV Deletion 20482838
nsv514344 CNV Loss 21397061
esv5916 CNV Loss 19470904
esv21847 CNV Gain 19812545
nsv820580 CNV Deletion 20802225
esv2612022 CNV Deletion 19546169
nsv819265 CNV Loss 19587683

Variation tolerance for RNF144B Gene

Residual Variation Intolerance Score: 36% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.36; 26.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNF144B Gene

HapMap Linkage Disequilibrium report
RNF144B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF144B Gene

Disorders for RNF144B Gene

Relevant External Links for RNF144B

Genetic Association Database (GAD)
RNF144B
Human Genome Epidemiology (HuGE) Navigator
RNF144B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RNF144B

No disorders were found for RNF144B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF144B Gene

Publications for RNF144B Gene

  1. The p53-inducible E3 ubiquitin ligase p53RFP induces p53-dependent apoptosis. (PMID: 16427630) Huang J. … Shu H.-B. (FEBS Lett. 2006) 3 4 23 67
  2. p53RFP, a p53-inducible RING-finger protein, regulates the stability of p21WAF1. (PMID: 12853982) Ng C.-C. … Nakamura Y. (Oncogene 2003) 3 23
  3. RNF144A, an E3 ubiquitin ligase for DNA-PKcs, promotes apoptosis during DNA damage. (PMID: 24979766) Ho S.R. … Lin W.C. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3
  4. PIR2/Rnf144B regulates epithelial homeostasis by mediating degradation of p21WAF1 and p63. (PMID: 23128396) Conforti F. … Sayan B.S. (Oncogene 2013) 3
  5. Genome-wide association study link novel loci to endometriosis. (PMID: 23472165) Albertsen H.M. … Ward K. (PLoS ONE 2013) 3

Products for RNF144B Gene

Sources for RNF144B Gene

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