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Aliases for RNF144A Gene

Aliases for RNF144A Gene

  • Ring Finger Protein 144A 2 3
  • UbcM4-Interacting Protein 4 3 4
  • RING Finger Protein 144A 4 5
  • Ring Finger Protein 144 2 3
  • UBCE7IP4 3 4
  • RNF144 3 4
  • Ubiquitin Conjugating Enzyme 7 Interacting Protein 4 3
  • Ubiquitin-Conjugating Enzyme 7-Interacting Protein 4 4
  • Probable E3 Ubiquitin-Protein Ligase RNF144A 3
  • E3 Ubiquitin-Protein Ligase RNF144A 3
  • EC 2.3.2.- 4
  • KIAA0161 4
  • EC 6.3.2 61

External Ids for RNF144A Gene

Previous HGNC Symbols for RNF144A Gene

  • RNF144

Previous GeneCards Identifiers for RNF144A Gene

  • GC02P007057

Summaries for RNF144A Gene

Entrez Gene Summary for RNF144A Gene

  • The protein encoded by this protein contains a RING finger, a motif known to be involved in protein-DNA and protein-protein interactions. The mouse counterpart of this protein has been shown to interact with Ube2l3/UbcM4, which is an ubiquitin-conjugating enzyme involved in embryonic development. [provided by RefSeq, Jul 2008]

GeneCards Summary for RNF144A Gene

RNF144A (Ring Finger Protein 144A) is a Protein Coding gene. Among its related pathways are Metabolism of proteins. GO annotations related to this gene include ligase activity. An important paralog of this gene is RNF144B.

UniProtKB/Swiss-Prot for RNF144A Gene

  • E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates the ubiquitination and degradation of the DNA damage kinase PRKDC.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF144A Gene

Genomics for RNF144A Gene

Regulatory Elements for RNF144A Gene

Enhancers for RNF144A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F007006 1.2 Ensembl ENCODE 25.8 +92.7 92681 6.5 PKNOX1 ATF1 CREB3L1 SIN3A ELK1 GATA2 FOS KDM4B NCOA1 REST RNF144A RNF144A-AS1 GC02M007018
GH02F007013 1 Ensembl ENCODE 23.8 +98.6 98632 4.4 CTCF PKNOX1 ESRRA SIN3A MAX RAD21 GATA3 CTBP1 POLR2A GATA2 RNF144A RNF144A-AS1 GC02M007018
GH02F006992 0.8 Ensembl ENCODE 25.2 +76.3 76291 2.6 SCRT1 CTCF FOXP2 MNT RAD21 MAFK NR2F2 RNF144A RNF144A-AS1 GC02M007018
GH02F006879 1.2 Ensembl ENCODE 11.5 -36.4 -36400 2.6 HDAC1 PKNOX1 CBX3 ARNT TBL1XR1 ZBTB40 CHAMP1 CBX5 GATA2 ETV6 RNF144A RNF144A-AS1 CMPK2 GC02P006897
GH02F007031 1.6 FANTOM5 Ensembl ENCODE 8.6 +114.6 114613 2.0 PKNOX1 MLX ARID4B SIN3A ZNF48 YY1 SLC30A9 ZNF207 FOS SP5 RNF144A ENSG00000272002 GC02M007018 GC02M007055
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RNF144A on UCSC Golden Path with GeneCards custom track

Promoters for RNF144A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000011108 508 1801 ZFP64 SIN3A RAD21 RARA EGR1 TBX21 TGIF2 TFDP1 IKZF1 NBN

Genomic Location for RNF144A Gene

Chromosome:
2
Start:
6,917,392 bp from pter
End:
7,076,197 bp from pter
Size:
158,806 bases
Orientation:
Plus strand

Genomic View for RNF144A Gene

Genes around RNF144A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF144A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF144A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF144A Gene

Proteins for RNF144A Gene

  • Protein details for RNF144A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50876-R144A_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase RNF144A
    Protein Accession:
    P50876
    Secondary Accessions:
    • D6W4Y6
    • Q585H5

    Protein attributes for RNF144A Gene

    Size:
    292 amino acids
    Molecular mass:
    32890 Da
    Quaternary structure:
    • Interacts with UBE2L3.
    SequenceCaution:
    • Sequence=BAA11478.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RNF144A Gene

neXtProt entry for RNF144A Gene

Selected DME Specific Peptides for RNF144A Gene

P50876:
  • EGCAQMMCKNCKH
  • CLKQYVELLIKEG
  • TPFVLCC
  • ENEIECMVA
  • GPCRNKLGHSRASV
  • CQAVCQL

Post-translational modifications for RNF144A Gene

Domains & Families for RNF144A Gene

Gene Families for RNF144A Gene

Protein Domains for RNF144A Gene

Suggested Antigen Peptide Sequences for RNF144A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P50876

UniProtKB/Swiss-Prot:

R144A_HUMAN :
  • Members of the RBR family are atypical E3 ligases. They interact with the E2 conjugating enzyme UBE2L3 and function like HECT-type E3 enzymes: they bind E2s via the first RING domain, but require an obligate trans-thiolation step during the ubiquitin transfer, requiring a conserved cysteine residue in the second RING domain.
  • Belongs to the RBR family. RNF144 subfamily.
  • Contains 1 IBR-type zinc finger.
Domain:
  • Members of the RBR family are atypical E3 ligases. They interact with the E2 conjugating enzyme UBE2L3 and function like HECT-type E3 enzymes: they bind E2s via the first RING domain, but require an obligate trans-thiolation step during the ubiquitin transfer, requiring a conserved cysteine residue in the second RING domain.
Family:
  • Belongs to the RBR family. RNF144 subfamily.
Similarity:
  • Contains 1 IBR-type zinc finger.
  • Contains 2 RING-type zinc fingers.
genes like me logo Genes that share domains with RNF144A: view

Function for RNF144A Gene

Molecular function for RNF144A Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates the ubiquitination and degradation of the DNA damage kinase PRKDC.

Enzyme Numbers (IUBMB) for RNF144A Gene

Gene Ontology (GO) - Molecular Function for RNF144A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IEA --
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0031624 ubiquitin conjugating enzyme binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RNF144A: view
genes like me logo Genes that share phenotypes with RNF144A: view

Animal Model Products

miRNA for RNF144A Gene

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNF144A Gene

Localization for RNF144A Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF144A Gene

Cell membrane; Single-pass membrane protein. Cytoplasmic vesicle membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNF144A gene
Compartment Confidence
plasma membrane 5
golgi apparatus 5
endosome 4
nucleus 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RNF144A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IBA --
GO:0005794 Golgi apparatus IDA 10942595
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RNF144A: view

Pathways & Interactions for RNF144A Gene

genes like me logo Genes that share pathways with RNF144A: view

Pathways by source for RNF144A Gene

UniProtKB/Swiss-Prot P50876-R144A_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for RNF144A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IBA --
GO:0016567 protein ubiquitination IEA --
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA --
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA --
genes like me logo Genes that share ontologies with RNF144A: view

No data available for SIGNOR curated interactions for RNF144A Gene

Transcripts for RNF144A Gene

Unigene Clusters for RNF144A Gene

Ring finger protein 144A:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF144A Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c · 14d
SP1: - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - - - - -
SP4:
SP5: -
SP6: - - - -
SP7: - - - - - - - -
SP8: -
SP9:
SP10: -

Relevant External Links for RNF144A Gene

GeneLoc Exon Structure for
RNF144A
ECgene alternative splicing isoforms for
RNF144A

Expression for RNF144A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RNF144A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNF144A Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.9) and Brain - Cerebellum (x4.2).

Protein differential expression in normal tissues from HIPED for RNF144A Gene

This gene is overexpressed in Platelet (63.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RNF144A Gene



Protein tissue co-expression partners for RNF144A Gene

NURSA nuclear receptor signaling pathways regulating expression of RNF144A Gene:

RNF144A

SOURCE GeneReport for Unigene cluster for RNF144A Gene:

Hs.22146
genes like me logo Genes that share expression patterns with RNF144A: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for RNF144A Gene

Orthologs for RNF144A Gene

This gene was present in the common ancestor of animals.

Orthologs for RNF144A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNF144A 34 35
  • 99.54 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RNF144A 35
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNF144A 34 35
  • 91.1 (n)
rat
(Rattus norvegicus)
Mammalia Rnf144a 34
  • 89.73 (n)
mouse
(Mus musculus)
Mammalia Rnf144a 34 16 35
  • 89.16 (n)
cow
(Bos Taurus)
Mammalia RNF144A 34 35
  • 88.01 (n)
oppossum
(Monodelphis domestica)
Mammalia RNF144A 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves RNF144A 34 35
  • 79.57 (n)
lizard
(Anolis carolinensis)
Reptilia RNF144A 35
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf144a 34
  • 76.14 (n)
zebrafish
(Danio rerio)
Actinopterygii rnf144ab 35
  • 82 (a)
OneToMany
rnf144aa 34 35
  • 78.08 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005143 34
  • 58.18 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG33144 34 35
  • 57.93 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3687 35
  • 37 (a)
OneToMany
Species where no ortholog for RNF144A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF144A Gene

ENSEMBL:
Gene Tree for RNF144A (if available)
TreeFam:
Gene Tree for RNF144A (if available)

Paralogs for RNF144A Gene

Paralogs for RNF144A Gene

(1) SIMAP similar genes for RNF144A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RNF144A: view

Variants for RNF144A Gene

Sequence variations from dbSNP and Humsavar for RNF144A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10167072 -- 6,932,804(+) AACCA(A/G)TGAAC intron-variant, utr-variant-5-prime
rs10167162 -- 6,962,955(+) AAAAG(A/G)TGGAT intron-variant
rs10170175 -- 7,008,429(+) AGAAC(A/C)GCAGG intron-variant
rs10171085 -- 7,049,396(+) GCAAT(A/G)AATGA intron-variant, utr-variant-3-prime
rs10173029 -- 7,058,686(+) CCTCT(A/G)TTATG intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for RNF144A Gene

Variant ID Type Subtype PubMed ID
nsv833326 CNV loss 17160897
nsv580913 CNV gain 21841781
nsv526590 CNV loss 19592680
nsv508073 OTHER sequence alteration 20534489
nsv2598 CNV deletion 18451855
nsv2597 CNV insertion 18451855
nsv1118850 CNV deletion 24896259
esv3589736 CNV loss 21293372
esv2719597 CNV deletion 23290073
esv2719595 CNV deletion 23290073
esv24593 CNV loss 19812545
esv1768137 CNV deletion 17803354

Variation tolerance for RNF144A Gene

Residual Variation Intolerance Score: 31.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNF144A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNF144A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF144A Gene

Disorders for RNF144A Gene

Relevant External Links for RNF144A

Genetic Association Database (GAD)
RNF144A
Human Genome Epidemiology (HuGE) Navigator
RNF144A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RNF144A

No disorders were found for RNF144A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF144A Gene

Publications for RNF144A Gene

  1. A family of structurally related RING finger proteins interacts specifically with the ubiquitin-conjugating enzyme UbcM4. (PMID: 10431818) Martinez-Noel G. … Harbers K. (FEBS Lett. 1999) 2 3 4 64
  2. Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8724849) Nagase T. … Nomura N. (DNA Res. 1996) 2 3 4 64
  3. RNF144A, an E3 ubiquitin ligase for DNA-PKcs, promotes apoptosis during DNA damage. (PMID: 24979766) Ho S.R. … Lin W.C. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3 4 64
  4. Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs. (PMID: 20195266) Adkins D.E. … van den Oord E.J. (Mol. Psychiatry 2011) 3 46 64
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64

Products for RNF144A Gene

Sources for RNF144A Gene

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