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Aliases for RNF144A Gene

Aliases for RNF144A Gene

  • Ring Finger Protein 144A 2 3
  • Ubiquitin-Conjugating Enzyme 7-Interacting Protein 4 3 4
  • UbcM4-Interacting Protein 4 3 4
  • Ring Finger Protein 144 2 3
  • UBCE7IP4 3 4
  • RNF144 3 4
  • Ubiquitin Conjugating Enzyme 7 Interacting Protein 4 3
  • Probable E3 Ubiquitin-Protein Ligase RNF144A 3
  • RING Finger Protein 144A 4
  • EC 6.3.2.- 4
  • KIAA0161 4
  • EC 6.3.2 63

External Ids for RNF144A Gene

Previous HGNC Symbols for RNF144A Gene

  • RNF144

Previous GeneCards Identifiers for RNF144A Gene

  • GC02P007057

Summaries for RNF144A Gene

Entrez Gene Summary for RNF144A Gene

  • The protein encoded by this protein contains a RING finger, a motif known to be involved in protein-DNA and protein-protein interactions. The mouse counterpart of this protein has been shown to interact with Ube2l3/UbcM4, which is an ubiquitin-conjugating enzyme involved in embryonic development. [provided by RefSeq, Jul 2008]

GeneCards Summary for RNF144A Gene

RNF144A (Ring Finger Protein 144A) is a Protein Coding gene. GO annotations related to this gene include ligase activity. An important paralog of this gene is RNF19A.

UniProtKB/Swiss-Prot for RNF144A Gene

  • E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates the ubiquitination and degradation of the DNA damage kinase PRKDC.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF144A Gene

Genomics for RNF144A Gene

Regulatory Elements for RNF144A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RNF144A Gene

Chromosome:
2
Start:
6,917,392 bp from pter
End:
7,076,197 bp from pter
Size:
158,806 bases
Orientation:
Plus strand

Genomic View for RNF144A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNF144A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF144A Gene

Proteins for RNF144A Gene

  • Protein details for RNF144A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50876-R144A_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase RNF144A
    Protein Accession:
    P50876
    Secondary Accessions:
    • D6W4Y6
    • Q585H5

    Protein attributes for RNF144A Gene

    Size:
    292 amino acids
    Molecular mass:
    32890 Da
    Quaternary structure:
    • Interacts with UBE2L3.
    SequenceCaution:
    • Sequence=BAA11478.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RNF144A Gene

neXtProt entry for RNF144A Gene

Proteomics data for RNF144A Gene at MOPED

Selected DME Specific Peptides for RNF144A Gene

Post-translational modifications for RNF144A Gene

Other Protein References for RNF144A Gene

Domains & Families for RNF144A Gene

Gene Families for RNF144A Gene

Protein Domains for RNF144A Gene

Suggested Antigen Peptide Sequences for RNF144A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P50876

UniProtKB/Swiss-Prot:

R144A_HUMAN :
  • Belongs to the RBR family. RNF144 subfamily.
  • Contains 1 IBR-type zinc finger.
Family:
  • Belongs to the RBR family. RNF144 subfamily.
Similarity:
  • Contains 1 IBR-type zinc finger.
  • Contains 2 RING-type zinc fingers.
genes like me logo Genes that share domains with RNF144A: view

Function for RNF144A Gene

Molecular function for RNF144A Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates the ubiquitination and degradation of the DNA damage kinase PRKDC.

Enzyme Numbers (IUBMB) for RNF144A Gene

Gene Ontology (GO) - Molecular Function for RNF144A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity --
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0031624 ubiquitin conjugating enzyme binding IBA --
genes like me logo Genes that share ontologies with RNF144A: view

Phenotypes for RNF144A Gene

GenomeRNAi human phenotypes for RNF144A:
genes like me logo Genes that share phenotypes with RNF144A: view

Animal Model Products

CRISPR Products

miRNA for RNF144A Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNF144A

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for RNF144A Gene

Localization for RNF144A Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF144A Gene

Cell membrane; Single-pass membrane protein. Cytoplasmic vesicle membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNF144A Gene COMPARTMENTS Subcellular localization image for RNF144A gene
Compartment Confidence
golgi apparatus 5
plasma membrane 3

Gene Ontology (GO) - Cellular Components for RNF144A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IBA --
GO:0005794 Golgi apparatus IDA 10942595
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030659 cytoplasmic vesicle membrane IEA --
genes like me logo Genes that share ontologies with RNF144A: view

Pathways & Interactions for RNF144A Gene

SuperPathways for RNF144A Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot P50876-R144A_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for RNF144A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IBA --
GO:0016567 protein ubiquitination --
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA --
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA --
genes like me logo Genes that share ontologies with RNF144A: view

No data available for Pathways by source and SIGNOR curated interactions for RNF144A Gene

Drugs & Compounds for RNF144A Gene

No Compound Related Data Available

Transcripts for RNF144A Gene

Unigene Clusters for RNF144A Gene

Ring finger protein 144A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNF144A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF144A Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c · 14d
SP1: - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - - - - -
SP4:
SP5: -
SP6: - - - -
SP7: - - - - - - - -
SP8: -
SP9:
SP10: -

Relevant External Links for RNF144A Gene

GeneLoc Exon Structure for
RNF144A
ECgene alternative splicing isoforms for
RNF144A

Expression for RNF144A Gene

mRNA expression in normal human tissues for RNF144A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNF144A Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.9) and Brain - Cerebellum (x4.2).

Protein differential expression in normal tissues from HIPED for RNF144A Gene

This gene is overexpressed in Platelet (63.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RNF144A Gene



SOURCE GeneReport for Unigene cluster for RNF144A Gene Hs.22146

genes like me logo Genes that share expression patterns with RNF144A: view

Protein tissue co-expression partners for RNF144A Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for RNF144A Gene

Orthologs for RNF144A Gene

This gene was present in the common ancestor of animals.

Orthologs for RNF144A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RNF144A 35
  • 88.01 (n)
  • 94.18 (a)
RNF144A 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNF144A 35
  • 91.1 (n)
  • 96.23 (a)
RNF144A 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnf144a 35
  • 89.16 (n)
  • 96.58 (a)
Rnf144a 16
Rnf144a 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RNF144A 35
  • 99.54 (n)
  • 99.66 (a)
RNF144A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnf144a 35
  • 89.73 (n)
  • 95.89 (a)
oppossum
(Monodelphis domestica)
Mammalia RNF144A 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RNF144A 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves RNF144A 35
  • 79.57 (n)
  • 92.12 (a)
RNF144A 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RNF144A 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf144a 35
  • 76.14 (n)
  • 89.04 (a)
zebrafish
(Danio rerio)
Actinopterygii rnf144aa 35
  • 78.08 (n)
  • 86.3 (a)
rnf144aa 36
  • 86 (a)
OneToMany
rnf144ab 36
  • 82 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005143 35
  • 58.18 (n)
  • 54.91 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG33144 35
  • 57.93 (n)
  • 52.03 (a)
CG33144 36
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3687 36
  • 37 (a)
OneToMany
Species with no ortholog for RNF144A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF144A Gene

ENSEMBL:
Gene Tree for RNF144A (if available)
TreeFam:
Gene Tree for RNF144A (if available)

Paralogs for RNF144A Gene

Paralogs for RNF144A Gene

(1) SIMAP similar genes for RNF144A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RNF144A: view

Variants for RNF144A Gene

Sequence variations from dbSNP and Humsavar for RNF144A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs309289 -- 7,050,066(+) AGAAC(A/T)GTTTG intron-variant
rs309290 -- 7,049,569(+) TTCAA(A/C/T)GACAC intron-variant
rs309291 -- 7,049,529(+) GAAGA(G/T)GACAA intron-variant
rs309292 -- 7,049,266(+) CACTG(C/T)ATAGT intron-variant
rs309293 -- 7,049,223(+) AGGGA(C/T)GAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNF144A Gene

Variant ID Type Subtype PubMed ID
nsv833326 CNV Loss 17160897
esv24593 CNV Loss 19812545
nsv2597 CNV Insertion 18451855
esv2719595 CNV Deletion 23290073
esv2719597 CNV Deletion 23290073
esv1768137 CNV Deletion 17803354
nsv508073 CNV Loss 20534489
nsv2598 CNV Loss 18451855
nsv526590 CNV Loss 19592680

Variation tolerance for RNF144A Gene

Residual Variation Intolerance Score: 31.43% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNF144A Gene

HapMap Linkage Disequilibrium report
RNF144A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF144A Gene

Disorders for RNF144A Gene

Relevant External Links for RNF144A

Genetic Association Database (GAD)
RNF144A
Human Genome Epidemiology (HuGE) Navigator
RNF144A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RNF144A
genes like me logo Genes that share disorders with RNF144A: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF144A Gene

Publications for RNF144A Gene

  1. A family of structurally related RING finger proteins interacts specifically with the ubiquitin-conjugating enzyme UbcM4. (PMID: 10431818) Martinez-Noel G. … Harbers K. (FEBS Lett. 1999) 2 67
  2. Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8724849) Nagase T. … Nomura N. (DNA Res. 1996) 2 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. RNF144A, an E3 ubiquitin ligase for DNA-PKcs, promotes apoptosis during DNA damage. (PMID: 24979766) Ho S.R. … Lin W.C. (Proc. Natl. Acad. Sci. U.S.A. 2014) 67
  5. A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study. (PMID: 22075330) Granada M. … O'Connor G.T. (J. Allergy Clin. Immunol. 2012) 67

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