RNF141 Gene
protein-coding GIFtS: 44
GCID: GC11M010533
|
|
ring finger protein 141
| |
Aliases
for RNF141 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ring Finger Protein 1411 2 | | ZNF2301 2 3 | | ZFP261 2 | | Zinc Finger Protein 2302 3 | | C3HC4-Like Zinc Finger Protein2 |
Export aliases for RNF141 gene to outside databasesPrevious GC identifers: GC11M010575 GC11M010500 GC11M010497 GC11M010489 GC11M010205 |
Summaries
for RNF141 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RNF141:
The protein encoded by this gene contains a RING finger, a motif known to be involved in protein-DNA andprotein-protein interactions. Abundant expression of this gene was found in the testicular tissue of fertile men, butwas not detected in azoospermic patients. Studies of the mouse counterpart suggest that this gene may function as atestis specific transcription factor during spermatogenesis. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: RN141_HUMAN, Q8WVD5Function: May be involved in spermatogenesis
|
Genomic Views
for RNF141 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_009237.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RNF141 gene promoter:
STAT5B STAT1 STAT4 ATF-2 STAT1beta STAT5A STAT1alpha MZF-1 STAT2 STAT3
Other transcription factors
Search SABiosciences Chromatin IP Primers for RNF141
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF141 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11p15.4 Ensembl cytogenetic band: 11p15.4 HGNC cytogenetic band: 11p15.3RNF141 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M010533: view genomic region
(about GC identifiers)
Start:
|
10,533,225 bp from pter |
End:
|
10,562,777 bp from pter |
Size:
|
29,553 bases |
Orientation:
|
minus strand |
|
Proteins
for RNF141 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RN141_HUMAN, Q8WVD5 (See
protein sequence)Recommended Name: RING finger protein 141 Size: 230 amino acids; 25535 Da
1 PDB 3D structure from  and Proteopedia  for RNF141:2ECN (3D)
Secondary accessions: A8K149 Q9NZB4Alternative splicing: 2 isoforms: Q8WVD5-1 Q8WVD5-2 Explore the universe of human proteins at neXtProt for RNF141: NX_Q8WVD5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8WVD5
RNF141 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_057506.2
ENSEMBL proteins: ENSP00000265981 ENSP00000434320 ENSP00000435086 ENSP00000437167
Human Recombinant Protein Products:
RNF141 Antibody Products:
Assay Products for RNF141: |
Protein
Domains /
Families
for RNF141 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RNF141 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8WVD5ProtoNet protein and cluster: Q8WVD5 1 Blocks protein family: IPB001841 Zn-finger
UniProtKB/Swiss-Prot: RN141_HUMAN, Q8WVD5Similarity: Contains 1 RING-type zinc finger |
Function
for RNF141 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RN141_HUMAN, Q8WVD5Function: May be involved in spermatogenesis
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF141 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF141
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RNF141 (NM_016422) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RNF141 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF141 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF141 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
RNF141 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for RNF141:
|
Pathways & Interactions
for RNF141 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNF141
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5/7 Interacting proteins for RNF141 (Q8WVD53 ENSP000002659814) via UniProtKB, MINT, STRING, and/or I2D (see all 7)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
RNF141 for ontologies About GeneDecksing
|
Drugs & Compounds
for RNF141 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RNF141
Search CenterWatch for drugs/clinical trials and news about RNF141 / RN141
|
Transcripts
for RNF141 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RNF141 gene: NM_016422.3 Unigene Cluster for RNF141: Ring finger protein 141 Hs.44685 [show with all ESTs]Unigene Representative Sequence: NM_0164225 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000265981(uc001mis.1 uc009yga.1) ENST00000534281 ENST00000528665
ENST00000533412 ENST00000530156
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF141 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF141
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RNF141 (NM_016422) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RNF141 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF141 |
Additional cDNA sequence: AF214680.1 AK289764.1 AK309367.1 BC018104.1 BT006662.1 13 DOTS entries: DT.100778410 DT.92013603 DT.120736773 DT.120736767 DT.441449 DT.91650236 DT.100695430 DT.91971977 DT.100022197 DT.95309961 DT.100785791 DT.101976472 DT.75123312 24/149 AceView cDNA sequences (see all 149): AA133472 AL598903 BX644137 AW451929 AI560000 BM981158 NM_016422 CB144704 AA682244 BE644771 BQ694964 BQ229248 BM845081 CR599604 AA417863 BX108878 AI494498 AI214345 BC018104 AI885788 BG163477 N35020 BI599205 BG896637
GeneLoc Exon Structure
|
Expression
for RNF141 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RNF141 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AACTCTAAGG
About this image
See RNF141 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RNF141
SOURCE GeneReport for Unigene cluster: Hs.44685
UniProtKB/Swiss-Prot: RN141_HUMAN, Q8WVD5Tissue specificity: Isoform 1 is testis-specific. Isoform 2 is expressed in heart, brain, skeletal muscle, kidney andpancreas. Isoform 1 is not expressed in fetus or in azoospermic patients
SABiosciences Custom PCR Arrays for RNF141
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNF141
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RNF141 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNF141 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNF141 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF141 |
Orthologs
for RNF141 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for RNF141 gene from 6/14 species (see all 14) About this table
ENSEMBL Gene Tree for RNF141 (if available)
TreeFam Gene Tree for RNF141 (if available) |
Paralogs
for RNF141 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RNF141 gene
RNF141 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for RNF141
PGOHUM00000257938
|
Genomic Variants
for RNF141 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RNF141 (10533225 - 10562777 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for RNF141
1 CNV: 58485 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNF141 |
|
Disorders
/ Diseases
for RNF141 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for RNF141 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RNF141 gene integrated from 9 sources:
(articles sorted by number of sources associating them with RNF141) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The shorter zinc finger protein ZNF230 gene message is transcribed in fertile male testes and may be related to human spermatogenesis. (PubMed id 11672448)1, 2, 3 Zhang S....Vogt P.H. (2001)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Systematic analysis of dimeric E3-RING interactions re veals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)1 Woodsmith J....Sanderson C.M. (2012)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- High-throughput mapping of a dynamic signaling network in mammalian cells. (PubMed id 15761153)1 Barrios-Rodiles M....Wrana J.L. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Molecular cloning and characterization of a mouse spermatogenesis-related ring finger gene znf230. (PubMed id 12804569)1 Qiu W....Wu Q. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
- The characterization of multiple forms of kynurenine formidase in Drosophila melanogaster. (PubMed id 50862)1 Moore G.P. and Sullivan D.T. (1975)
|
External Searches for RNF141 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RNF141 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RNF141 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RNF141 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RNF141 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RNF141 gene:
Search GeneIP for patents involving RNF141
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RNF141 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for RNF141 | | OriGene shRNA RFP for RNF141 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RNF141 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNF141 | | | OriGene Protein Over-expression Lysate for RNF141 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RNF141 | | OriGene 3'-UTR Clone for RNF141 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF141 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF141 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for RNF141 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RNF141 | | OriGene Custom Protein Services for RNF141 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RNF141 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNF141 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF141 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNF141 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNF141 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNF141 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for RNF141 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | RNF141 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF141 |
|  |  |  | | | | ThermoFisher Antibodies for RNF141 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF141 |
|
|
|
|
