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Aliases for RNF141 Gene

Aliases for RNF141 Gene

  • Ring Finger Protein 141 2 3 5
  • Zinc Finger Protein 230 3 4
  • ZNF230 3 4
  • C3HC4-Like Zinc Finger Protein 3
  • ZFP26 3

External Ids for RNF141 Gene

Previous GeneCards Identifiers for RNF141 Gene

  • GC11M010575
  • GC11M010500
  • GC11M010497
  • GC11M010489
  • GC11M010533
  • GC11M010205
  • GC11M010513
  • GC11M010518
  • GC11M010522
  • GC11M010527
  • GC11M010541

Summaries for RNF141 Gene

Entrez Gene Summary for RNF141 Gene

  • The protein encoded by this gene contains a RING finger, a motif known to be involved in protein-DNA and protein-protein interactions. Abundant expression of this gene was found in the testicular tissue of fertile men, but was not detected in azoospermic patients. Studies of the mouse counterpart suggest that this gene may function as a testis specific transcription factor during spermatogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for RNF141 Gene

RNF141 (Ring Finger Protein 141) is a Protein Coding gene. GO annotations related to this gene include ubiquitin-protein transferase activity.

UniProtKB/Swiss-Prot for RNF141 Gene

  • May be involved in spermatogenesis.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF141 Gene

Genomics for RNF141 Gene

Regulatory Elements for RNF141 Gene

Enhancers for RNF141 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G010588 1.7 FANTOM5 Ensembl ENCODE dbSUPER 20.5 -50.8 -50789 7.3 HDAC1 PKNOX1 ATF1 TBL1XR1 ARNT TCF12 GATA2 FOS ETV6 SMARCA5 MRVI1-AS1 RNF141 MRVI1 AMPD3 LYVE1 GC11M010566
GH11G010622 1.6 FANTOM5 Ensembl ENCODE dbSUPER 16.3 -82.8 -82764 2.4 BCOR CTCF ESRRA ZNF175 RAD21 ZNF316 SMC3 NFE2 ETV6 MAFK RNF141 CTR9 MRVI1 MRVI1-AS1 SBF2 AMPD3 LYVE1 GC11M010667
GH11G010502 1.3 FANTOM5 Ensembl ENCODE dbSUPER 18.7 +37.7 37730 2.2 ZNF512 MAX FOS RNF141 MRVI1-AS1 AMPD3 CTR9 LYVE1 MRVI1 SBF2 ZBED5 EIF4G2 MIR4485
GH11G010505 1 ENCODE dbSUPER 19.4 +35.2 35222 1.9 PKNOX1 JUN HLF NR2F1 JUNB TBX21 JUND GATA2 EED IKZF1 MRVI1-AS1 RNF141 CTR9 LYVE1 MRVI1 MIR4485 GC11M010474
GH11G010611 1.3 FANTOM5 Ensembl ENCODE dbSUPER 13.3 -71.4 -71353 1.7 SMARCA5 CBX8 RFX1 RNF2 SMARCA4 IKZF1 RNF141 MRVI1-AS1 MRVI1 AMPD3 SBF2 LYVE1 GC11M010667
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RNF141 on UCSC Golden Path with GeneCards custom track

Promoters for RNF141 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000036760 430 1601 HDGF HNRNPUL1 AGO1 ARID4B SIN3A FEZF1 YY1 ZNF207 ZNF143 KLF13

Genomic Location for RNF141 Gene

Chromosome:
11
Start:
10,511,678 bp from pter
End:
10,541,230 bp from pter
Size:
29,553 bases
Orientation:
Minus strand

Genomic View for RNF141 Gene

Genes around RNF141 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF141 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF141 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF141 Gene

Proteins for RNF141 Gene

  • Protein details for RNF141 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WVD5-RN141_HUMAN
    Recommended name:
    RING finger protein 141
    Protein Accession:
    Q8WVD5
    Secondary Accessions:
    • A8K149
    • Q9NZB4

    Protein attributes for RNF141 Gene

    Size:
    230 amino acids
    Molecular mass:
    25535 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RNF141 Gene

    Alternative splice isoforms for RNF141 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNF141 Gene

Post-translational modifications for RNF141 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RNF141 Gene

No data available for DME Specific Peptides for RNF141 Gene

Domains & Families for RNF141 Gene

Gene Families for RNF141 Gene

Protein Domains for RNF141 Gene

Suggested Antigen Peptide Sequences for RNF141 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RNF141: view

No data available for UniProtKB/Swiss-Prot for RNF141 Gene

Function for RNF141 Gene

Molecular function for RNF141 Gene

UniProtKB/Swiss-Prot Function:
May be involved in spermatogenesis.

Gene Ontology (GO) - Molecular Function for RNF141 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0004842 ubiquitin-protein transferase activity IDA 24105792
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RNF141: view
genes like me logo Genes that share phenotypes with RNF141: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNF141 Gene

Localization for RNF141 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF141 Gene

Membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNF141 gene
Compartment Confidence
nucleus 4
cytoskeleton 2
cytosol 1

Gene Ontology (GO) - Cellular Components for RNF141 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with RNF141: view

Pathways & Interactions for RNF141 Gene

SuperPathways for RNF141 Gene

No Data Available

Interacting Proteins for RNF141 Gene

Gene Ontology (GO) - Biological Process for RNF141 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0051865 protein autoubiquitination IDA 24105792
genes like me logo Genes that share ontologies with RNF141: view

No data available for Pathways by source and SIGNOR curated interactions for RNF141 Gene

Drugs & Compounds for RNF141 Gene

No Compound Related Data Available

Transcripts for RNF141 Gene

Unigene Clusters for RNF141 Gene

Ring finger protein 141:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF141 Gene

No ASD Table

Relevant External Links for RNF141 Gene

GeneLoc Exon Structure for
RNF141
ECgene alternative splicing isoforms for
RNF141

Expression for RNF141 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNF141 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNF141 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.3).

Protein differential expression in normal tissues from HIPED for RNF141 Gene

This gene is overexpressed in Bone (54.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RNF141 Gene



NURSA nuclear receptor signaling pathways regulating expression of RNF141 Gene:

RNF141

SOURCE GeneReport for Unigene cluster for RNF141 Gene:

Hs.44685

mRNA Expression by UniProt/SwissProt for RNF141 Gene:

Q8WVD5-RN141_HUMAN
Tissue specificity: Isoform 1 is testis-specific. Isoform 2 is expressed in heart, brain, skeletal muscle, kidney and pancreas. Isoform 1 is not expressed in fetus or in azoospermic patients.

Evidence on tissue expression from TISSUES for RNF141 Gene

  • Nervous system(4.9)
  • Lung(4.3)
genes like me logo Genes that share expression patterns with RNF141: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNF141 Gene

Orthologs for RNF141 Gene

This gene was present in the common ancestor of animals.

Orthologs for RNF141 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNF141 34 35
  • 99.57 (n)
dog
(Canis familiaris)
Mammalia RNF141 34 35
  • 95.36 (n)
cow
(Bos Taurus)
Mammalia RNF141 34 35
  • 94.93 (n)
mouse
(Mus musculus)
Mammalia Rnf141 34 16 35
  • 92.61 (n)
rat
(Rattus norvegicus)
Mammalia rnf141 34
  • 92.46 (n)
oppossum
(Monodelphis domestica)
Mammalia RNF141 35
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RNF141 35
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves RNF141 34 35
  • 77.54 (n)
lizard
(Anolis carolinensis)
Reptilia RNF141 35
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf141 34
  • 72.81 (n)
zebrafish
(Danio rerio)
Actinopterygii rnf141 34 35
  • 69.82 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000736 34
  • 45.56 (n)
worm
(Caenorhabditis elegans)
Secernentea F54B11.5 35
  • 28 (a)
OneToOne
Species where no ortholog for RNF141 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RNF141 Gene

ENSEMBL:
Gene Tree for RNF141 (if available)
TreeFam:
Gene Tree for RNF141 (if available)

Paralogs for RNF141 Gene

Pseudogenes.org Pseudogenes for RNF141 Gene

genes like me logo Genes that share paralogs with RNF141: view

No data available for Paralogs for RNF141 Gene

Variants for RNF141 Gene

Sequence variations from dbSNP and Humsavar for RNF141 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000220279 -- 10,527,044(+) GAAAT(G/T)ATGGA intron-variant
rs1000299471 -- 10,536,653(+) TTTAA(A/G)CAAAC intron-variant
rs1000328860 -- 10,533,687(+) TATGC(A/C)CCCCT intron-variant
rs1000433200 -- 10,516,890(+) AACTA(C/T)AGTCC intron-variant
rs1000443536 -- 10,533,949(+) TTACA(C/T)AGCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNF141 Gene

Variant ID Type Subtype PubMed ID
esv3625358 CNV gain 21293372
nsv1044011 CNV gain 25217958
nsv7675 CNV insertion 18451855
nsv819964 CNV loss 19587683
nsv972946 CNV duplication 23825009

Variation tolerance for RNF141 Gene

Residual Variation Intolerance Score: 60% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.61; 30.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNF141 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNF141

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF141 Gene

Disorders for RNF141 Gene

Relevant External Links for RNF141

Genetic Association Database (GAD)
RNF141
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RNF141

No disorders were found for RNF141 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF141 Gene

Publications for RNF141 Gene

  1. The shorter zinc finger protein ZNF230 gene message is transcribed in fertile male testes and may be related to human spermatogenesis. (PMID: 11672448) Zhang S. … Vogt P.H. (Biochem. J. 2001) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Multifunctional reagents for quantitative proteome-wide analysis of protein modification in human cells and dynamic profiling of protein lipidation during vertebrate development. (PMID: 25807930) Broncel M. … Tate E.W. (Angew. Chem. Int. Ed. 2015) 4 64
  4. The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines. (PMID: 25260751) Charlaftis N. … Gallagher E. (EMBO J. 2014) 3 64
  5. Global profiling of co- and post-translationally N-myristoylated proteomes in human cells. (PMID: 25255805) Thinon E. … Tate E.W. (Nat. Commun. 2014) 4 64

Products for RNF141 Gene

Sources for RNF141 Gene

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