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Aliases for RNF141 Gene

Aliases for RNF141 Gene

  • Ring Finger Protein 141 2 3
  • Zinc Finger Protein 230 3 4
  • ZNF230 3 4
  • C3HC4-Like Zinc Finger Protein 3
  • ZFP26 3

External Ids for RNF141 Gene

Previous GeneCards Identifiers for RNF141 Gene

  • GC11M010575
  • GC11M010500
  • GC11M010497
  • GC11M010489
  • GC11M010533
  • GC11M010205

Summaries for RNF141 Gene

Entrez Gene Summary for RNF141 Gene

  • The protein encoded by this gene contains a RING finger, a motif known to be involved in protein-DNA and protein-protein interactions. Abundant expression of this gene was found in the testicular tissue of fertile men, but was not detected in azoospermic patients. Studies of the mouse counterpart suggest that this gene may function as a testis specific transcription factor during spermatogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for RNF141 Gene

RNF141 (Ring Finger Protein 141) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression.

UniProtKB/Swiss-Prot for RNF141 Gene

  • May be involved in spermatogenesis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF141 Gene

Genomics for RNF141 Gene

Regulatory Elements for RNF141 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RNF141 Gene

10,511,678 bp from pter
10,541,230 bp from pter
29,553 bases
Minus strand

Genomic View for RNF141 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNF141 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF141 Gene

Proteins for RNF141 Gene

  • Protein details for RNF141 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RING finger protein 141
    Protein Accession:
    Secondary Accessions:
    • A8K149
    • Q9NZB4

    Protein attributes for RNF141 Gene

    230 amino acids
    Molecular mass:
    25535 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RNF141 Gene

    Alternative splice isoforms for RNF141 Gene


neXtProt entry for RNF141 Gene

Proteomics data for RNF141 Gene at MOPED

Post-translational modifications for RNF141 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RNF141 Gene

Antibody Products

No data available for DME Specific Peptides for RNF141 Gene

Domains for RNF141 Gene

Gene Families for RNF141 Gene

Protein Domains for RNF141 Gene

Suggested Antigen Peptide Sequences for RNF141 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 RING-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF141: view

Function for RNF141 Gene

Molecular function for RNF141 Gene

UniProtKB/Swiss-Prot Function:
May be involved in spermatogenesis.

Gene Ontology (GO) - Molecular Function for RNF141 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0004842 ubiquitin-protein transferase activity IDA 24105792
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with RNF141: view

Phenotypes for RNF141 Gene

MGI mutant phenotypes for RNF141:
inferred from 1 alleles
GenomeRNAi human phenotypes for RNF141:
genes like me logo Genes that share phenotypes with RNF141: view

Animal Model Products

miRNA for RNF141 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNF141

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RNF141 Gene

Localization for RNF141 Gene

Subcellular locations from

Jensen Localization Image for RNF141 Gene COMPARTMENTS Subcellular localization image for RNF141 gene
Compartment Confidence
nucleus 3
cytoskeleton 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RNF141 Gene

Pathways for RNF141 Gene

SuperPathways for RNF141 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with RNF141: view

Pathways by source for RNF141 Gene

2 Reactome pathways for RNF141 Gene

Interacting Proteins for RNF141 Gene

Gene Ontology (GO) - Biological Process for RNF141 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0051865 protein autoubiquitination IDA 24105792
genes like me logo Genes that share ontologies with RNF141: view

Transcripts for RNF141 Gene

Unigene Clusters for RNF141 Gene

Ring finger protein 141:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNF141

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF141 Gene

No ASD Table

Relevant External Links for RNF141 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNF141 Gene

mRNA expression in normal human tissues for RNF141 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNF141 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (4.3).

Protein differential expression in normal tissues for RNF141 Gene

This gene is overexpressed in Bone (54.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RNF141 Gene

SOURCE GeneReport for Unigene cluster for RNF141 Gene Hs.44685

mRNA Expression by UniProt/SwissProt for RNF141 Gene

Tissue specificity: Isoform 1 is testis-specific. Isoform 2 is expressed in heart, brain, skeletal muscle, kidney and pancreas. Isoform 1 is not expressed in fetus or in azoospermic patients.
genes like me logo Genes that share expressions with RNF141: view

Primer Products

In Situ Assay Products

No data available for Expression partners for RNF141 Gene

Orthologs for RNF141 Gene

This gene was present in the common ancestor of animals.

Orthologs for RNF141 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RNF141 35
  • 94.93 (n)
  • 97.83 (a)
RNF141 36
  • 98 (a)
(Canis familiaris)
Mammalia RNF141 35
  • 95.36 (n)
  • 97.39 (a)
RNF141 36
  • 97 (a)
(Mus musculus)
Mammalia Rnf141 35
  • 92.61 (n)
  • 99.13 (a)
Rnf141 16
Rnf141 36
  • 99 (a)
(Pan troglodytes)
Mammalia RNF141 35
  • 99.57 (n)
  • 98.7 (a)
RNF141 36
  • 99 (a)
(Rattus norvegicus)
Mammalia rnf141 35
  • 92.46 (n)
  • 98.26 (a)
(Monodelphis domestica)
Mammalia RNF141 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia RNF141 36
  • 91 (a)
(Gallus gallus)
Aves RNF141 35
  • 77.54 (n)
  • 84.35 (a)
RNF141 36
  • 83 (a)
(Anolis carolinensis)
Reptilia RNF141 36
  • 83 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf141 35
  • 72.81 (n)
  • 82.46 (a)
(Danio rerio)
Actinopterygii rnf141 35
  • 69.82 (n)
  • 78.83 (a)
rnf141 36
  • 79 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000736 35
  • 45.56 (n)
  • 33.17 (a)
(Caenorhabditis elegans)
Secernentea F54B11.5 36
  • 28 (a)
Species with no ortholog for RNF141:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RNF141 Gene

Gene Tree for RNF141 (if available)
Gene Tree for RNF141 (if available)

Paralogs for RNF141 Gene Pseudogenes for RNF141 Gene

genes like me logo Genes that share paralogs with RNF141: view

No data available for Paralogs for RNF141 Gene

Variants for RNF141 Gene

Sequence variations from dbSNP and Humsavar for RNF141 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs12448 -- 10,512,405(-) CACTT(A/G)CTGAT utr-variant-3-prime
rs1043778 -- 10,513,267(-) CAAGG(A/G)AAAAC utr-variant-3-prime
rs1047730 -- 10,514,751(-) TTCCC(A/G)TGTCT utr-variant-3-prime
rs1065052 -- 10,534,042(-) TTTCT(C/T)GGGAG synonymous-codon, reference
rs1074375 -- 10,517,312(+) TAGTA(A/G)CTATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNF141 Gene

Variant ID Type Subtype PubMed ID
nsv819964 CNV Loss 19587683
nsv7675 CNV Insertion 18451855

Relevant External Links for RNF141 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF141 Gene

Disorders for RNF141 Gene

Relevant External Links for RNF141

Genetic Association Database (GAD)

No disorders were found for RNF141 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for RNF141 Gene

Publications for RNF141 Gene

  1. The shorter zinc finger protein ZNF230 gene message is transcribed in fertile male testes and may be related to human spermatogenesis. (PMID: 11672448) Zhang S. … Vogt P.H. (Biochem. J. 2001) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. High-throughput mapping of a dynamic signaling network in mammalian cells. (PMID: 15761153) Barrios-Rodiles M. … Wrana J.L. (Science 2005) 3
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  5. Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks. (PMID: 22493164) Woodsmith J. … Sanderson C.M. (Mol. Cell Proteomics 2012) 3

Products for RNF141 Gene

Sources for RNF141 Gene

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