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RNF141 Gene

protein-coding   GIFtS: 48
GCID: GC11M010533

Ring Finger Protein 141

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ring Finger Protein 1411 2
Zinc Finger Protein 2302 3
ZNF2302 3
ZFP262
C3HC4-Like Zinc Finger Protein2

External Ids:    HGNC: 211591   Entrez Gene: 508622   Ensembl: ENSG000001103157   UniProtKB: Q8WVD53   

Export aliases for RNF141 gene to outside databases

Previous GC identifers: GC11M010575 GC11M010500 GC11M010497 GC11M010489 GC11M010205


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RNF141 Gene:
The protein encoded by this gene contains a RING finger, a motif known to be involved in protein-DNA and
protein-protein interactions. Abundant expression of this gene was found in the testicular tissue of fertile men,
but was not detected in azoospermic patients. Studies of the mouse counterpart suggest that this gene may
function as a testis specific transcription factor during spermatogenesis. (provided by RefSeq, Jul 2008)

GeneCards Summary for RNF141 Gene:
RNF141 (ring finger protein 141) is a protein-coding gene.

UniProtKB/Swiss-Prot: RN141_HUMAN, Q8WVD5
Function: May be involved in spermatogenesis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_009237.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the RNF141 gene promoter:
         STAT5B   STAT1   STAT4   ATF-2   STAT1beta   STAT5A   STAT1alpha   MZF-1   STAT2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNF141 promoter sequence
   Search Chromatin IP Primers for RNF141

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNF141


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.4   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.3

RNF141 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF141 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M010533:  view genomic region     (about GC identifiers)

Start:
10,533,225 bp from pter      End:
10,562,777 bp from pter
Size:
29,553 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RN141_HUMAN, Q8WVD5 (See protein sequence)
Recommended Name: RING finger protein 141  
Size: 230 amino acids; 25535 Da
1 PDB 3D structure from and Proteopedia for RNF141:
2ECN (3D)    
Secondary accessions: A8K149 Q9NZB4
Alternative splicing: 2 isoforms:  Q8WVD5-1   Q8WVD5-2   

Explore the universe of human proteins at neXtProt for RNF141: NX_Q8WVD5

Explore proteomics data for RNF141 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RNF141 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057506.2  
    ENSEMBL proteins: 
     ENSP00000265981   ENSP00000434320   ENSP00000435086   ENSP00000437167  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers

    3 InterPro protein domains:
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q8WVD5

    ProtoNet protein and cluster: Q8WVD5

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: RN141_HUMAN, Q8WVD5
    Similarity: Contains 1 RING-type zinc finger


    Find genes that share domains with RNF141           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RN141_HUMAN, Q8WVD5
    Function: May be involved in spermatogenesis

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0046872metal ion binding ----
         
    Find genes that share ontologies with RNF141           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for RNF141:
     Downregulation of NF-kappaB pa 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Rnf141):
     reproductive system 

    Find genes that share phenotypes with RNF141           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RNF141
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    hsa-mir-192-5p (MIRT026225), hsa-mir-32-5p (MIRT028281), hsa-mir-361-5p (MIRT020094), hsa-mir-124-3p (MIRT022226)

    Block miRNA regulation of human, mouse, rat RNF141 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RNF141 (see all 65):
    hsa-miR-3130-5p hsa-miR-128 hsa-miR-371-5p hsa-miR-3161 hsa-miR-92b hsa-miR-130a* hsa-miR-27a hsa-miR-32
    SwitchGear 3'UTR luciferase reporter plasmidRNF141 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytoskeleton1
    cytosol1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RNF141
    Interactions:

        Search GeneGlobe Interaction Network for RNF141

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for RNF141 (Q8WVD53 ENSP000002659814) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMURF1Q9HCE73, ENSP000003546214I2D: score=2 STRING: ENSP00000354621
    DTX3ENSP000003380504STRING: ENSP00000338050
    TRIM24ENSP000003405074STRING: ENSP00000340507
    TRIM8ENSP000003021204STRING: ENSP00000302120
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with RNF141           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RNF141 (RN141)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RNF141 gene: 
    NM_016422.3  

    Unigene Cluster for RNF141:

    Ring finger protein 141
    Hs.44685  [show with all ESTs]
    Unigene Representative Sequence: NM_016422
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000265981(uc001mis.1 uc009yga.1) ENST00000534281 ENST00000528665
    ENST00000533412 ENST00000530156
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate RNF141 (see all 65):
    hsa-miR-3130-5p hsa-miR-128 hsa-miR-371-5p hsa-miR-3161 hsa-miR-92b hsa-miR-130a* hsa-miR-27a hsa-miR-32
    SwitchGear 3'UTR luciferase reporter plasmidRNF141 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat RNF141

    Additional mRNA sequence: 

    AF214680.1 AK289764.1 AK309367.1 BC018104.1 BT006662.1 

    13 DOTS entries:

    DT.100778410  DT.92013603  DT.120736773  DT.120736767  DT.441449  DT.91650236  DT.100695430  DT.91971977 
    DT.95309961  DT.100022197  DT.100785791  DT.101976472  DT.75123312 

    Selected AceView cDNA sequences (see all 149):

    AA682244 BE644771 BQ229248 BC018104 BX644137 NM_016422 CB144704 AI560000 
    BM845081 AA133472 BX108878 AI214345 AL598903 BQ694964 AI494498 AW451929 
    AA417863 CR599604 AI885788 BM981158 AW341588 CD653068 CD641282 BI546369 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RNF141 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACTCTAAGG
    RNF141 Expression
    About this image


    RNF141 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Testis (Reproductive System)
     
     Esophagus (Gastrointestinal Tract)
    RNF141 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RNF141 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.44685

    UniProtKB/Swiss-Prot: RN141_HUMAN, Q8WVD5
    Tissue specificity: Isoform 1 is testis-specific. Isoform 2 is expressed in heart, brain, skeletal muscle, kidney
    and pancreas. Isoform 1 is not expressed in fetus or in azoospermic patients

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RNF141 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnf1411 , 5 ring finger protein 1411, 5 92.61(n)1
    99.13(a)1
      7 (57.87 cM)5
    671501  NM_025999.31  NP_080275.21 
     1108004325 
    chicken
    (Gallus gallus)
    Aves RNF1411 ring finger protein 141 77.54(n)
    84.35(a)
      423039  NM_001007925.1  NP_001007926.1 
    lizard
    (Anolis carolinensis)
    Reptilia RNF1416
    ring finger protein 141
    83(a)
    1 ↔ 1
    1(63517547-63525635)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia rnf1411 ring finger protein 141 72.81(n)
    82.46(a)
      548418  NM_001015701.1  NP_001015701.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rnf1411 ring finger protein 141 69.82(n)
    78.83(a)
      414846  NM_001007290.1  NP_001007291.1 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0007361 AgaP_AGAP000736 45.56(n)
    33.17(a)
      3289739  XM_559376.4  XP_559376.4 
    worm
    (Caenorhabditis elegans)
    Secernentea F54B11.56
    Protein F54B11.5 (F54B11.5) mRNA, complete cds
    28(a)
    1 ↔ 1
    X(13594124-13596067) WBGene00010028


    ENSEMBL Gene Tree for RNF141 (if available)
    TreeFam Gene Tree for RNF141 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RNF141 gene

    Find genes that share paralogs with RNF141           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for RNF141
    PGOHUM00000257938


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RNF141 (see all 572)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1397683051,2
    --10532755(+) AGGCCA/GCACAG 1 -- ds50010--------
    rs1496565861,2
    --10532780(+) CGGGCA/GAGTGA 1 -- ds50010--------
    rs786316411,2
    C,F--10532868(+) ACTGCG/ACATAC 1 -- ds50012Minor allele frequency- A:0.03WA 120
    rs745555601,2
    C,F--10532876(+) TACGAG/AGGATC 1 -- ds50012Minor allele frequency- A:0.03WA NA 238
    rs1909386151,2
    --10532882(+) GGATCG/TAGGTT 1 -- ds50010--------
    rs1824748821,2
    --10532907(+) AGAATC/TTAACT 1 -- ds50010--------
    rs120993821,2
    C,F--10532922(+) cctgaT/Agatct 1 -- ds50013Minor allele frequency- A:0.17NA WA 6
    rs49101491,2
    C,F,A,H--10533056(+) ACATAC/AGAACA 1 -- ds500122Minor allele frequency- A:0.29NS EA NA WA CSA 2348
    rs110428661,2
    C,F,A,H--10533153(+) CATCTG/CCAAGT 1 -- ds500118Minor allele frequency- C:0.20NS EA NA WA CSA 1182
    rs49101501,2
    C,F,A,H--10533173(+) ATTCCC/TGGATA 1 -- ds500120Minor allele frequency- T:0.29NS EA NA WA CSA 2346

    HapMap Linkage Disequilibrium report for RNF141 (10533225 - 10562777 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RNF141:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv7675CNV Insertion18451855
    nsv819964CNV Loss19587683

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with RNF141           About GenesLikeMe

    Genetic Association Database (GAD): RNF141

    Export disorders for RNF141 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RNF141 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with RNF141)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The shorter zinc finger protein ZNF230 gene message is transcribed in fertile male testes and may be related to human spermatogenesis. (PubMed id 11672448)1, 2, 3 Zhang S....Vogt P.H. (Biochem. J. 2001)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)1 Woodsmith J....Sanderson C.M. (amp 2012)
    4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    5. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)
    6. High-throughput mapping of a dynamic signaling network in mammalian cells. (PubMed id 15761153)1 Barrios-Rodiles M....Wrana J.L. (Science 2005)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Molecular cloning and characterization of a mouse spermatogenesis-related ring finger gene znf230. (PubMed id 12804569)1 Qiu W....Wu Q. (Biochem. Biophys. Res. Commun. 2003)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 50862 HGNC: 21159 AceView: RNF141 Ensembl:ENSG00000110315 euGenes: HUgn50862
    ECgene: RNF141 H-InvDB: RNF141

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RNF141 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RNF141 gene:
    Search GeneIP for patents involving RNF141

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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