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Aliases for RNF141 Gene

Aliases for RNF141 Gene

  • Ring Finger Protein 141 2 3 5
  • Zinc Finger Protein 230 3 4
  • ZNF230 3 4
  • C3HC4-Like Zinc Finger Protein 3
  • ZFP26 3

External Ids for RNF141 Gene

Previous GeneCards Identifiers for RNF141 Gene

  • GC11M010575
  • GC11M010500
  • GC11M010497
  • GC11M010489
  • GC11M010533
  • GC11M010205
  • GC11M010513
  • GC11M010518
  • GC11M010522
  • GC11M010527

Summaries for RNF141 Gene

Entrez Gene Summary for RNF141 Gene

  • The protein encoded by this gene contains a RING finger, a motif known to be involved in protein-DNA and protein-protein interactions. Abundant expression of this gene was found in the testicular tissue of fertile men, but was not detected in azoospermic patients. Studies of the mouse counterpart suggest that this gene may function as a testis specific transcription factor during spermatogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for RNF141 Gene

RNF141 (Ring Finger Protein 141) is a Protein Coding gene. GO annotations related to this gene include ubiquitin-protein transferase activity.

UniProtKB/Swiss-Prot for RNF141 Gene

  • May be involved in spermatogenesis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF141 Gene

Genomics for RNF141 Gene

Regulatory Elements for RNF141 Gene

Enhancers for RNF141 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F010588 1.2 FANTOM5 Ensembl ENCODE 20.5 -50.8 -50789 7.3 HDAC1 PKNOX1 ATF1 ARNT TBL1XR1 GATA2 FOS ETV6 SMARCA5 NCOA1 MRVI1-AS1 RNF141 MRVI1 AMPD3 LYVE1 GC11M010560
GH11F010505 0.4 ENCODE 19.4 +35.2 35222 1.9 PKNOX1 HLF JUN JUNB TBX21 JUND IKZF1 ZKSCAN8 EED FOS MRVI1-AS1 RNF141 CTR9 LYVE1 MRVI1 GC11M010511 GC11M010474
GH11F010502 1.7 FANTOM5 Ensembl ENCODE 18.7 +37.7 37730 2.2 ZNF512 MAX RNF141 MRVI1-AS1 AMPD3 CTR9 LYVE1 MRVI1 SBF2 ZBED5 EIF4G2 GC11M010511
GH11F010622 1.1 FANTOM5 Ensembl ENCODE 16.3 -83.3 -83271 3.8 BCOR CTCF ESRRA ZNF175 RAD21 FOSL1 ZNF316 GATA3 SMC3 ETV6 RNF141 CTR9 MRVI1 MRVI1-AS1 SBF2 AMPD3 LYVE1 GC11M010667
GH11F010611 1.3 FANTOM5 Ensembl ENCODE 13.3 -71.3 -71298 1.9 SMARCA5 CBX8 RFX1 SMARCA4 RNF2 RNF141 MRVI1-AS1 MRVI1 AMPD3 SBF2 LYVE1 GC11M010667
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around RNF141 on UCSC Golden Path with GeneCards custom track

Promoters for RNF141 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000187938 530 2201 HDGF PKNOX1 ARID4B SIN3A FEZF1 YY1 ZNF207 ZNF143 FOS KLF13

Genomic Location for RNF141 Gene

10,511,678 bp from pter
10,541,230 bp from pter
29,553 bases
Minus strand

Genomic View for RNF141 Gene

Genes around RNF141 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF141 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF141 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF141 Gene

Proteins for RNF141 Gene

  • Protein details for RNF141 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RING finger protein 141
    Protein Accession:
    Secondary Accessions:
    • A8K149
    • Q9NZB4

    Protein attributes for RNF141 Gene

    230 amino acids
    Molecular mass:
    25535 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RNF141 Gene

    Alternative splice isoforms for RNF141 Gene


neXtProt entry for RNF141 Gene

Post-translational modifications for RNF141 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RNF141 Gene

No data available for DME Specific Peptides for RNF141 Gene

Domains & Families for RNF141 Gene

Gene Families for RNF141 Gene

Protein Domains for RNF141 Gene

Suggested Antigen Peptide Sequences for RNF141 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 RING-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF141: view

Function for RNF141 Gene

Molecular function for RNF141 Gene

UniProtKB/Swiss-Prot Function:
May be involved in spermatogenesis.

Gene Ontology (GO) - Molecular Function for RNF141 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0004842 ubiquitin-protein transferase activity IDA 24105792
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RNF141: view
genes like me logo Genes that share phenotypes with RNF141: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNF141 Gene

Localization for RNF141 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF141 Gene

Membrane; Lipid-anchor.

Subcellular locations from

Jensen Localization Image for RNF141 Gene COMPARTMENTS Subcellular localization image for RNF141 gene
Compartment Confidence
nucleus 4
cytoskeleton 2
cytosol 1

Gene Ontology (GO) - Cellular Components for RNF141 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with RNF141: view

Pathways & Interactions for RNF141 Gene

SuperPathways for RNF141 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RNF141 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0051865 protein autoubiquitination IDA 24105792
genes like me logo Genes that share ontologies with RNF141: view

No data available for Pathways by source and SIGNOR curated interactions for RNF141 Gene

Transcripts for RNF141 Gene

Unigene Clusters for RNF141 Gene

Ring finger protein 141:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF141 Gene

No ASD Table

Relevant External Links for RNF141 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNF141 Gene

mRNA expression in normal human tissues for RNF141 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNF141 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.3).

Protein differential expression in normal tissues from HIPED for RNF141 Gene

This gene is overexpressed in Bone (54.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RNF141 Gene

NURSA nuclear receptor signaling pathways regulating expression of RNF141 Gene:


SOURCE GeneReport for Unigene cluster for RNF141 Gene:


mRNA Expression by UniProt/SwissProt for RNF141 Gene:

Tissue specificity: Isoform 1 is testis-specific. Isoform 2 is expressed in heart, brain, skeletal muscle, kidney and pancreas. Isoform 1 is not expressed in fetus or in azoospermic patients.
genes like me logo Genes that share expression patterns with RNF141: view

Primer Products

No data available for Protein tissue co-expression partners for RNF141 Gene

Orthologs for RNF141 Gene

This gene was present in the common ancestor of animals.

Orthologs for RNF141 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RNF141 34 35
  • 99.57 (n)
(Canis familiaris)
Mammalia RNF141 34 35
  • 95.36 (n)
(Bos Taurus)
Mammalia RNF141 34 35
  • 94.93 (n)
(Mus musculus)
Mammalia Rnf141 34 16 35
  • 92.61 (n)
(Rattus norvegicus)
Mammalia rnf141 34
  • 92.46 (n)
(Monodelphis domestica)
Mammalia RNF141 35
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia RNF141 35
  • 91 (a)
(Gallus gallus)
Aves RNF141 34 35
  • 77.54 (n)
(Anolis carolinensis)
Reptilia RNF141 35
  • 83 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf141 34
  • 72.81 (n)
(Danio rerio)
Actinopterygii rnf141 34 35
  • 69.82 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000736 34
  • 45.56 (n)
(Caenorhabditis elegans)
Secernentea F54B11.5 35
  • 28 (a)
Species where no ortholog for RNF141 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RNF141 Gene

Gene Tree for RNF141 (if available)
Gene Tree for RNF141 (if available)

Paralogs for RNF141 Gene Pseudogenes for RNF141 Gene

genes like me logo Genes that share paralogs with RNF141: view

No data available for Paralogs for RNF141 Gene

Variants for RNF141 Gene

Sequence variations from dbSNP and Humsavar for RNF141 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1043778 -- 10,513,267(-) CAAGG(A/G)AAAAC utr-variant-3-prime
rs10458930 -- 10,527,921(+) attgt(C/G)aggtg intron-variant
rs10458931 -- 10,527,926(+) caggt(A/G)tgaga intron-variant
rs1047730 -- 10,514,751(-) TTCCC(A/G)TGTCT utr-variant-3-prime
rs10500725 -- 10,516,174(+) CAGAG(A/G)TATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNF141 Gene

Variant ID Type Subtype PubMed ID
esv3625358 CNV gain 21293372
nsv1044011 CNV gain 25217958
nsv7675 CNV insertion 18451855
nsv819964 CNV loss 19587683
nsv972946 CNV duplication 23825009

Variation tolerance for RNF141 Gene

Residual Variation Intolerance Score: 60% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.61; 30.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNF141 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF141 Gene

Disorders for RNF141 Gene

Relevant External Links for RNF141

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RNF141 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF141 Gene

Publications for RNF141 Gene

  1. The shorter zinc finger protein ZNF230 gene message is transcribed in fertile male testes and may be related to human spermatogenesis. (PMID: 11672448) Zhang S. … Vogt P.H. (Biochem. J. 2001) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Multifunctional reagents for quantitative proteome-wide analysis of protein modification in human cells and dynamic profiling of protein lipidation during vertebrate development. (PMID: 25807930) Broncel M. … Tate E.W. (Angew. Chem. Int. Ed. 2015) 4 64
  4. Protein microarray characterization of the S-nitrosoproteome. (PMID: 24105792) Lee Y.I. … Dawson T.M. (Mol. Cell Proteomics 2014) 3 64
  5. The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines. (PMID: 25260751) Charlaftis N. … Gallagher E. (EMBO J. 2014) 3 64

Products for RNF141 Gene

Sources for RNF141 Gene

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