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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RNF14 Gene

protein-coding GIFtS: 57
GCID: GC05P141326

ring finger protein 14

Explore 5 diseases affiliated with
RNF14 via

MalaCards

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Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ring Finger Protein 14¹ ² ³		Androgen Receptor Associated Protein 54²
ARA54¹ ² ³ ⁵		E3 Ubiquitin-Protein Ligase RNF14²
HFB30¹ ² ³		EC 6.3.2.-³
TRIAD2¹ ²		Triad2 Protein³
Androgen Receptor-Associated Protein 54² ³

External Ids:	HGNC: 10058¹	Entrez Gene: 9604²	Ensembl: ENSG00000013561⁷	OMIM: 605675⁵	UniProtKB: Q9UBS8³

Export aliases for RNF14 gene to outside databases

Previous GC identifers: GC05P141171 GC05P141929 GC05P141329 GC05P141374 GC05P136489

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RNF14:

The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein

interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR

target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the

AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s)

and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Six alternatively spliced

transcript variants encoding two distinct isoforms have been reported. (provided by RefSeq, Jan 2011)

UniProtKB/Swiss-Prot: RNF14_HUMAN, Q9UBS8

Function: Might act as an E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating

enzymes and then transfers it to substrates, which could be nuclear proteins. Could play a role as a coactivator for

androgen- and, to a lesser extent, progesterone-dependent transcription

Gene Wiki entry for RNF14

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_029289.11

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RNF14 gene promoter:
RelA NF-kappaB1 NF-kappaB FOXL1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RNF14 promoter sequence

Search SABiosciences Chromatin IP Primers for RNF14

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF14

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q23.3-q31.1 Ensembl cytogenetic band: 5q31.3 HGNC cytogenetic band: 5q23.3-q31.1

RNF14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF14 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P141326: view genomic region (about GC identifiers)

Start:	141,337,893 bp from pter	End:	141,369,856 bp from pter
Size:	31,964 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RNF14_HUMAN, Q9UBS8 (See protein sequence)

Recommended Name: E3 ubiquitin-protein ligase RNF14

Size: 474 amino acids; 53837 Da

Subunit: Interacts with the ubiquitin-conjugating enzymes UBE2E1 and UBE2E2. Interacts with AR/androgen receptor;

testosterone- and RNF6-regulated it promotes AR transcriptional activity

Subcellular location: Cytoplasm. Nucleus

Caution: Lacks the His residue in the RING-type domain 2 that is one of the conserved features of the family

Secondary accessions: A0AV26 A6NMR2 A8MTW5 B3KN72 B7ZLV2 D3DQE4 O94793 Q6IBV0

Alternative splicing: 2 isoforms: Q9UBS8-1 Q9UBS8-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RNF14: NX_Q9UBS8

Post-translational modifications:

RING-type zinc finger-dependent and UBE2E2-dependent autoubiquitination¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9UBS8

RNF14 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (6 alternative transcripts):

NP_001188294.1 NP_004281.1 NP_899645.1 NP_899646.1 NP_899647.1 NP_899648.1

ENSEMBL proteins:

ENSP00000423420 ENSP00000423273 ENSP00000421780 ENSP00000378028 ENSP00000420837

ENSP00000378022 ENSP00000426832 ENSP00000422650 ENSP00000422527 ENSP00000425361

ENSP00000423294 ENSP00000348462 ENSP00000324956 ENSP00000442490 ENSP00000378023

ENSP00000378027

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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for RNF14

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	11322894
GO:0005737	cytoplasm	IDA	--

RNF14 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for RNF14

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RNF14 for domains About GeneDecksing

5 InterPro domains/families:

IPR016135 UBQ-conjugating_enzyme/RWD

IPR017907 Znf_RING_CS

IPR002867 Znf_C6HC

IPR001841 Znf_RING

IPR006575 RWD-domain

Graphical View of Domain Structure for InterPro Entry Q9UBS8

ProtoNet protein and cluster: Q9UBS8

4 Blocks protein families:

IPB000608 Ubiquitin-conjugating enzymes

IPB001841 Zn-finger

IPB002867 Zn-finger

IPB006575 RWD

UniProtKB/Swiss-Prot: RNF14_HUMAN, Q9UBS8

Domain: The N-terminal destruction box (D-box) acts as a recognition signal for degradation via the

ubiquitin-proteasome pathway (By similarity)

Domain: The RING-type zinc finger is essential for the interaction with UBE2E2

Similarity: Belongs to the RBR family. RNF14 subfamily

Similarity: Contains 1 IBR-type zinc finger

Similarity: Contains 2 RING-type zinc fingers

Similarity: Contains 1 RWD domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: RNF14_HUMAN, Q9UBS8

Function: Might act as an E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating

enzymes and then transfers it to substrates, which could be nuclear proteins. Could play a role as a coactivator for

androgen- and, to a lesser extent, progesterone-dependent transcription

Genatlas biochemistry entry for RNF14:

RING finger protein 14,ubiquitously expressed

Enzyme Number (IUBMB): EC 6.3.2.-¹

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003713	transcription coactivator activity	TAS	10085091
GO:0005515	protein binding	IPI	19345326
GO:0008270	zinc ion binding	IEA	--
GO:0019787	small conjugating protein ligase activity	IDA	11322894
GO:0050681	androgen receptor binding	IPI	19345326

RNF14 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for RNF14:

High actin ratio cells

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for RNF14

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF14

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Androgen receptor signaling pathway

Androgen receptor signaling pathway

1.00

1 BioSystems Pathway for RNF14

Androgen receptor signaling pathway

UniProtKB/Swiss-Prot: RNF14_HUMAN, Q9UBS8

Pathway: Protein modification; protein ubiquitination

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for RNF14

STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

5/40 Interacting proteins for RNF14 (Q9UBS8^{1, 2, 3} ENSP00000324956⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 40)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
AR	P10275¹^,³, ENSP00000363822⁴	EBI-2130308,EBI-608057 I2D: score=3 STRING: ENSP00000363822
NR3C1	P04150³, ENSP00000231509⁴	I2D: score=2 STRING: ENSP00000231509
UBE2D2	P62837³, ENSP00000381717⁴	I2D: score=2 STRING: ENSP00000381717
UBE2D3	P61077³, ENSP00000349722⁴	I2D: score=2 STRING: ENSP00000349722
UBE2U	Q5VVX9³, ENSP00000360116⁴	I2D: score=2 STRING: ENSP00000360116

About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IDA	19345326
GO:0006357	regulation of transcription from RNA polymerase II promoter	TAS	10085091
GO:0007165	signal transduction	TAS	10085091
GO:0016567	protein ubiquitination	IEP	11322894

RNF14 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

RNF14 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RNF14
2 Novoseek chemical compound relationships for RNF14 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
hydroxyflutamide	89.1	1	10085091 (1)
testosterone	54	4	11155740 (1), 10085091 (1), 17110431 (1)

Search CenterWatch for drugs/clinical trials and news about RNF14

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RNF14 gene (6 alternative transcripts):

NM_001201365.1 NM_004290.4 NM_183398.2 NM_183399.2 NM_183400.2 NM_183401.2

Unigene Cluster for RNF14:

Ring finger protein 14

Hs.483616 [show with all ESTs]

Unigene Representative Sequence: NM_004290

18 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000511961 ENST00000506822 ENST00000513019 ENST00000394520(uc003llz.3 uc003lly.3 uc003lma.3 uc003lmb.3 uc003lmc.3 uc011dbg.2 uc011dbh.2 uc003lmd.3)

ENST00000514620 ENST00000502341 ENST00000506938 ENST00000394514 ENST00000512565

ENST00000515613 ENST00000507163 ENST00000506004 ENST00000507291 ENST00000356143

ENST00000347642 ENST00000540015 ENST00000394515 ENST00000394519

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RNF14
		8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate RNF14 (see all 17):
		hsa-miR-3163 hsa-miR-100* hsa-miR-199b-3p hsa-miR-2110 hsa-miR-199a-3p hsa-miR-526b hsa-miR-589* hsa-miR-3129-5p

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Additional cDNA sequence:

AB015333.1 AB022663.1 AF060544.1 AK023698.1 AK023884.1 AK057868.1 AK129515.1 AK294262.1

AK295965.1 BC126185.1 BC144061.1 BX647955.1 CR456702.1

24/27 DOTS entries (see all 27):

DT.451582 DT.120866185 DT.97859019 DT.95353016 DT.95353020 DT.100660212 DT.99971412 DT.100660213

DT.100694096 DT.92442560 DT.100036515 DT.95353017 DT.75167814 DT.95353019 DT.100660210 DT.100869742

DT.100036518 DT.100660211 DT.100696410 DT.120866165 DT.120866180 DT.92442559 DT.92442563 DT.95353009

24/345 AceView cDNA sequences (see all 345):

AI378351 CD370889 BI908916 AL547212 AA328279 AK129515 N75033 AI985502

BQ959504 AA771798 C21426 AI632610 AI935621 CA307558 CR616865 NM_183398

NM_183399 N76261 BI918925 AA564813 BQ771493 BM917554 NM_183400 AI935312

GeneLoc Exon Structure

5/20 Alternative Splicing Database (ASD) splice patterns (SP) for RNF14 (see all 20) About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	·	3c	·	3d	·	3e	^	4a	·	4b	^	5	^	6a	·	6b	·	6c	·	6d	^	7a	·	7b	·	7c	^	8a	·	8b	·	8c	·	8d	·	8e	^	9a	·	9b	^	10	^
SP1:																	-		-
SP2:
SP3:					-		-		-		-		-		-		-		-		-
SP4:							-		-		-		-		-		-		-												-		-		-
SP5:																	-		-												-		-		-

ExUns:	11a	·	11b	·	11c	^	12a	·	12b	^	13a	·	13b	·	13c
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for RNF14

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RNF14 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTTTATTTC

About this image
See RNF14 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RNF14

SOURCE GeneReport for Unigene cluster: Hs.483616

UniProtKB/Swiss-Prot: RNF14_HUMAN, Q9UBS8

Tissue specificity: Widely expressed

SABiosciences Expression via Pathway-Focused PCR Array including RNF14:

Ubiquitin Ligases in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for RNF14 gene from 9/25 species (see all 25) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Rnf14^{1 , 5}	ring finger protein 14^{1, 5}	87.97(n)¹ 90.51(a)¹		18 (20.20 cM)⁵ 56736¹ NM_001164621.1¹ NP_001158093.1¹ 38296635⁵
chicken (Gallus gallus)	Aves	RNF14⁶	Uncharacterized protein	81(a)	1 ↔ 1	13(17750907-17756624)
lizard (Anolis carolinensis)	Reptilia	RNF14⁶	--	72(a)	1 ↔ 1	2(127063070-127077994)
African clawed frog (Xenopus laevis)	Amphibia	Xl.3688²	Xenopus laevis transcribed sequence with moderate similarity more	75.97(n)		BX845389.1
zebrafish (Danio rerio)	Actinopterygii	CABZ01061592.3⁶ rnf14⁶ (see all 5)	ring finger protein 14 (see all 5)	58(a) 58(a) (see all 5)	many → 1 many → 1 (see all 5)	15(3646974-3651344) 21(40528614-40551250)
honey bee (Apis mellifera)	Insecta	--	--	37(a)	1 ↔ 1	GroupUn.1388(3242-5110)
worm (Caenorhabditis elegans)	Secernentea	F56D2.5³	--	30(a) (best of 2)		III(5650379-5652847) --
thale cress (Arabidopsis thaliana)	eudicotyledons	NHL8⁶	ubiquitin-protein ligase RNF14	19(a)	1 ↔ 1	1(11663070-11666058)
rice (Oryza sativa)	Liliopsida	Os04g0594000¹	hypothetical protein	44.48(n) 37.11(a)		4336840 NM_001060260.1 NP_001053725.1

ENSEMBL Gene Tree for RNF14 (if available)
TreeFam Gene Tree for RNF14 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RNF14 gene

RNF19B² RNF144A² RNF217² RNF19A² RNF144B²

RNF14 for paralogs About GeneDecksing

4 Pseudogenes.org Pseudogenes for RNF14
PGOHUM00000240359 PGOHUM00000245654 PGOHUM00000250891 PGOHUM00000233577

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs182295202^1,2		--	141344443(+)	`TGCCTC/TGGCCT`	2	--	us2k¹		0	--	--	--	--
rs186508421^1,2		--	141344457(+)	`AAAGGA/GCTGGG`	2	--	us2k¹		0	--	--	--	--
rs189715393^1,2		--	141344483(+)	`CACCAC/TGCCTG`	2	--	us2k¹		0	--	--	--	--
rs76293615^1,2	C	--	141344504(+)	`TTTTT-/TAAAAA`	2	--	us2k¹		0	--	--	--	--
rs7728738^1,2	C	--	141344510(+)	`TTTTTA/TTAAAA`	2	--	us2k¹		0	--	--	--	--
rs202036212^1,2		--	141344510(+)	`TTTTT-/ATAAAA`	2	--	us2k¹		0	--	--	--	--
rs164516^1,2	C,F,A,H	--	141344511(-)	`TTTTTT/AAAAAA`	2	--	us2k¹		6		NA WA	12
rs200200162^1,2		--	141344511(+)	`TTTTT-/AAAAAA`	2	--	us2k¹		0	--	--	--	--
rs190239560^1,2		--	141344512(+)	`TTTTTA/TAAAAA`	2	--	us2k¹		0	--	--	--	--
rs183197510^1,2		--	141344618(+)	`ACTTCC/TGTACT`	2	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for RNF14 (141337893 - 141369856 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RNF14: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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RNF14 for disorders           About GeneDecksing

OMIM gene information: 605675    OMIM disorders: --

5 diseases for RNF14:    About MalaCards

prostate cancer prostatitis azoospermia breast cancer

malaria

1 Novoseek disease relationship for RNF14 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
prostate cancer	52	4	17110431 (2), 11501969 (1), 10085091 (1)

Export disorders for RNF14 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for RNF14 gene, integrated from 9 sources (see all 36):
(articles sorted by number of sources associating them with RNF14)

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world of online information

Cloning and characterization of human prostate coactivator ARA54, a novel protein that associates with the androgen receptor. (PubMed id 10085091)^{1, 2, 3, 9} Kang H.-Y.... Chang C. (1999)
Isolation and characterization of a novel human gene (HFB30) which encodes a protein with a RING finger motif. (PubMed id 10320776)^{1, 2, 3} Ueki N.... Muramatsu M.-A. (1999)
N-terminally extended human ubiquitin-conjugating enzymes (E2s) mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8. (PubMed id 11322894)^{1, 2, 9} Ito K.... Okano Y. (2001)
Regulation of androgen receptor transcriptional activity and specificity by RNF6-induced ubiquitination. (PubMed id 19345326)^{1, 2} Xu K.... Qiu Y. (2009)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Selection system for genes encoding nuclear-targeted proteins. (PubMed id 9853615)^{1, 2} Ueki N.... Muramatsu M.-A. (1998)
Suppression of androgen receptor transactivation and prostate cancer cell growth by heterogeneous nuclear ribonucleoprotein A1 via interaction with androgen receptor coregulator ARA54. (PubMed id 17110431)^{1, 9} Yang Z....Chang C. (2007)
Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)¹ Woods N.T....Monteiro A.N. (2012)
Systematic analysis of dimeric E3-RING interactions re veals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)¹ Woodsmith J....Sanderson C.M. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 9604	HGNC: 10058	AceView: RNF14	Ensembl:ENSG00000013561	euGenes: HUgn9604
ECgene: RNF14	H-InvDB: RNF14

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for RNF14	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for RNF14	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for RNF14 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for RNF14 gene:
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GeneCards and IP:
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ring finger protein 14

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ring finger protein 14

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