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RNF14 Gene

protein-coding   GIFtS: 62
GCID: GC05P141402

Ring Finger Protein 14

  See RNF14-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ring Finger Protein 141 2 3     Androgen Receptor Associated Protein 542
ARA542 3 5     E3 Ubiquitin-Protein Ligase RNF142
Androgen Receptor-Associated Protein 542 3     EC 6.3.2.-3
HFB302 3     Triad2 Protein3
TRIAD22     

External Ids:    HGNC: 100581   Entrez Gene: 96042   Ensembl: ENSG000000135617   OMIM: 6056755   UniProtKB: Q9UBS83   

Export aliases for RNF14 gene to outside databases

Previous GC identifers: GC05P141171 GC05P141929 GC05P141329 GC05P141374 GC05P141326 GC05P136489 GC05P141358


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RNF14 Gene:
The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein
interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces
AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit
the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating
enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Six
alternatively spliced transcript variants encoding two distinct isoforms have been reported. (provided by RefSeq,
Jan 2011)

GeneCards Summary for RNF14 Gene:
RNF14 (ring finger protein 14) is a protein-coding gene. Diseases associated with RNF14 include prostate cancer. GO annotations related to this gene include transcription coactivator activity and small conjugating protein ligase activity.

UniProtKB/Swiss-Prot: RNF14_HUMAN, Q9UBS8
Function: Might act as an E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2
ubiquitin-conjugating enzymes and then transfers it to substrates, which could be nuclear proteins. Could play a
role as a coactivator for androgen- and, to a lesser extent, progesterone-dependent transcription

Gene Wiki entry for RNF14 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_029289.12  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RNF14 gene promoter:
         RelA   NF-kappaB1   NF-kappaB   FOXL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RNF14 promoter sequence
   Search Chromatin IP Primers for RNF14

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNF14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q23.3-q31.1   Ensembl cytogenetic band:  5q31.3   HGNC cytogenetic band: 5q23.3-q31.1

RNF14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF14 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P141402:  view genomic region     (about GC identifiers)

Start:
141,337,893 bp from pter      End:
141,369,856 bp from pter
Size:
31,964 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RNF14_HUMAN, Q9UBS8 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase RNF14  
Size: 474 amino acids; 53837 Da
Subunit: Interacts with the ubiquitin-conjugating enzymes UBE2E1 and UBE2E2. Interacts with AR/androgen receptor;
testosterone- and RNF6-regulated it promotes AR transcriptional activity
Caution: Lacks the His residue in the RING-type domain 2 that is one of the conserved features of the family
Secondary accessions: A0AV26 A6NMR2 A8MTW5 B3KN72 B7ZLV2 D3DQE4 O94793 Q6IBV0
Alternative splicing: 2 isoforms:  Q9UBS8-1   Q9UBS8-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RNF14: NX_Q9UBS8

Explore proteomics data for RNF14 at MOPED

Post-translational modifications: 

  • RING-type zinc finger-dependent and UBE2E2-dependent autoubiquitination1
  • Ubiquitination2 at Lys372, Lys386
  • Modification sites at PhosphoSitePlus

  • See RNF14 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001188294.1  NP_004281.1  NP_899645.1  NP_899646.1  NP_899647.1  NP_899648.1  

    ENSEMBL proteins: 
     ENSP00000423420   ENSP00000423273   ENSP00000421780   ENSP00000378028   ENSP00000420837  
     ENSP00000378022   ENSP00000426832   ENSP00000422650   ENSP00000422527   ENSP00000425361  
     ENSP00000423294   ENSP00000348462   ENSP00000324956   ENSP00000442490   ENSP00000378023  
     ENSP00000378027  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers

    5 InterPro protein domains:
     IPR016135 UBQ-conjugating_enzyme/RWD
     IPR017907 Znf_RING_CS
     IPR002867 Znf_C6HC
     IPR001841 Znf_RING
     IPR006575 RWD-domain

    Graphical View of Domain Structure for InterPro Entry Q9UBS8

    ProtoNet protein and cluster: Q9UBS8

    4 Blocks protein domains:
    IPB000608 Ubiquitin-conjugating enzymes
    IPB001841 Zn-finger
    IPB002867 Zn-finger
    IPB006575 RWD


    UniProtKB/Swiss-Prot: RNF14_HUMAN, Q9UBS8
    Domain: The N-terminal destruction box (D-box) acts as a recognition signal for degradation via the
    ubiquitin-proteasome pathway (By similarity)
    Domain: The RING-type zinc finger is essential for the interaction with UBE2E2
    Similarity: Belongs to the RBR family. RNF14 subfamily
    Similarity: Contains 1 IBR-type zinc finger
    Similarity: Contains 2 RING-type zinc fingers
    Similarity: Contains 1 RWD domain


    Find genes that share domains with RNF14           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RNF14_HUMAN, Q9UBS8
    Function: Might act as an E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2
    ubiquitin-conjugating enzymes and then transfers it to substrates, which could be nuclear proteins. Could play a
    role as a coactivator for androgen- and, to a lesser extent, progesterone-dependent transcription

         Genatlas biochemistry entry for RNF14:
    RING finger protein 14,ubiquitously expressed

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity TAS10085091
    GO:0005515protein binding IPI10085091
    GO:0008270zinc ion binding IEA--
    GO:0019787small conjugating protein ligase activity IDA11322894
    GO:0050681androgen receptor binding IPI19345326
         
    Find genes that share ontologies with RNF14           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for RNF14:
     High actin ratio cells 

    Animal Models:
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    hsa-mir-484 (MIRT041839)

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    Selected qRT-PCR Assays for microRNAs that regulate RNF14 (see all 17):
    hsa-miR-3163 hsa-miR-100* hsa-miR-199b-3p hsa-miR-2110 hsa-miR-199a-3p hsa-miR-526b hsa-miR-589* hsa-miR-3129-5p
    SwitchGear 3'UTR luciferase reporter plasmidRNF14 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RNF14

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RNF14_HUMAN, Q9UBS8: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA11322894
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with RNF14           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RNF14 About    
    See pathways by source

    SuperPathContained pathways About
    1Androgen receptor signaling pathway
    Androgen receptor signaling pathway


    1 BioSystems Pathway for RNF14
        Androgen receptor signaling pathway



    UniProtKB/Swiss-Prot: RNF14_HUMAN, Q9UBS8
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Array including RNF14: 

              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RNF14

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RNF14 (Q9UBS81, 2, 3 ENSP000003249564) via UniProtKB, MINT, STRING, and/or I2D (see all 60)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARP102751, 3, ENSP000003638224EBI-2130308,EBI-608057 I2D: score=3 STRING: ENSP00000363822
    NR3C1P041503, ENSP000002315094I2D: score=2 STRING: ENSP00000231509
    UBE2D2P628373, ENSP000003817174I2D: score=2 STRING: ENSP00000381717
    UBE2D3P610773, ENSP000003497224I2D: score=2 STRING: ENSP00000349722
    UBE2UQ5VVX93, ENSP000003601164I2D: score=2 STRING: ENSP00000360116
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IDA19345326
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS10085091
    GO:0007165signal transduction TAS10085091
    GO:0016567protein ubiquitination IEP11322894

    Find genes that share ontologies with RNF14           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RNF14

    2 Novoseek inferred chemical compound relationships for RNF14 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hydroxyflutamide 89.1 1 10085091 (1)
    testosterone 54 4 11155740 (1), 10085091 (1), 17110431 (1)



    Find genes that share compounds with RNF14           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RNF14 gene (6 alternative transcripts): 
    NM_001201365.1  NM_004290.4  NM_183398.2  NM_183399.2  NM_183400.2  NM_183401.2  

    Unigene Cluster for RNF14:

    Ring finger protein 14
    Hs.483616  [show with all ESTs]
    Unigene Representative Sequence: NM_004290
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000511961 ENST00000506822 ENST00000513019 ENST00000394520(uc003llz.3 uc003lly.3 uc003lma.3 uc003lmb.3 uc003lmc.3 uc011dbg.2 uc011dbh.2 uc003lmd.3)
    ENST00000514620 ENST00000502341 ENST00000506938 ENST00000394514 ENST00000512565
    ENST00000515613 ENST00000507163 ENST00000506004 ENST00000507291 ENST00000356143
    ENST00000347642 ENST00000540015 ENST00000394515 ENST00000394519
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    hsa-miR-3163 hsa-miR-100* hsa-miR-199b-3p hsa-miR-2110 hsa-miR-199a-3p hsa-miR-526b hsa-miR-589* hsa-miR-3129-5p
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      QuantiTect SYBR Green Assays in human, mouse, rat RNF14
      QuantiFast Probe-based Assays in human, mouse, rat RNF14

    Additional mRNA sequence: 

    AB015333.1 AB022663.1 AF060544.1 AK023698.1 AK023884.1 AK057868.1 AK129515.1 AK294262.1 
    AK295965.1 BC126185.1 BC144061.1 BX647955.1 CR456702.1 

    Selected DOTS entries (see all 27):

    DT.451582  DT.120866185  DT.97859019  DT.95353016  DT.95353020  DT.100660212  DT.99971412  DT.100660213 
    DT.100694096  DT.92442560  DT.100036515  DT.95353017  DT.75167814  DT.95353019  DT.100660210  DT.100869742 
    DT.100036518  DT.100660211  DT.100696410  DT.120866165  DT.120866180  DT.92442559  DT.92442563  DT.95353009 

    Selected AceView cDNA sequences (see all 345):

    AI538873 AL079570 CB250701 NM_183398 R53318 N76261 CR605413 BQ067509 
    N75033 AI935312 CR595278 BU622614 CB049101 BQ009136 CD370889 AA328279 
    AL547212 AA418072 AW575502 AI079776 BI908916 NM_004290 NM_183399 AA627060 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RNF14 (see all 20)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b ^ 10 ^
    SP1:                                                  -     -                                                                                                   
    SP2:                                                                                                                                                            
    SP3:              -     -     -     -     -     -     -     -     -                                                                                             
    SP4:                    -     -     -     -     -     -     -                                   -     -     -                                                   
    SP5:                                                  -     -                                   -     -     -                                                   

    ExUns: 11a · 11b · 11c ^ 12a · 12b ^ 13a · 13b · 13c
    SP1:                                                
    SP2:                                                
    SP3:                                                
    SP4:                                                
    SP5:                                                


    ECgene alternative splicing isoforms for RNF14

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RNF14 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTTATTTC
    RNF14 Expression
    About this image


    RNF14 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Limb (Muscoskeletal System)
             Limb Bud
     
     Liver (Hepatobiliary System)
             Perivenous Hepatocytes Liver Lobule
    RNF14 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RNF14 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.483616

    UniProtKB/Swiss-Prot: RNF14_HUMAN, Q9UBS8
    Tissue specificity: Widely expressed

        Pathway & Disease-focused RT2 Profiler PCR Array including RNF14: 
              Ubiquitin Ligases in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF14

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RNF14 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnf141 , 5 ring finger protein 141, 5 87.97(n)1
    90.51(a)1
      18 (20.20 cM)5
    567361  NM_020012.21  NP_064396.21 
     382966355 
    chicken
    (Gallus gallus)
    Aves RNF146
    RNF146
    Uncharacterized protein
    Gallus gallus ring finger protein 14 (RNF14), mRNA...
    77(a)
    77(a)
    many → 1
    many → 1
    13(16549132-16550501)
    13(16624523-16626069)
    lizard
    (Anolis carolinensis)
    Reptilia RNF146
    ring finger protein 14
    72(a)
    1 ↔ 1
    2(127063064-127078002)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.36882 Xenopus laevis transcribed sequence with moderate similarity more 75.97(n)    BX845389.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rnf146
    RNF14 (4 of 5)6
    (see all 5)
    ring finger protein 14
    (see all 5)
    58(a)
    58(a)
    (see all 5)
    many → 1
    many → 1
    (see all 5)
    21(40528614-40551250) ENSDARG00000043905
    15(3636173-3640564) ENSDARG00000090710
    worm
    (Caenorhabditis elegans)
    Secernentea F56D2.53   -- 30(a)
    (best of 2)
      III(5650379-5652847)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ITT1(YML068W)4 Protein that modulates the efficiency of translation more   --   13(137550-138944) 854934  NP_013643.1 
    rice
    (Oryza sativa)
    Liliopsida Os04g05940001 Os04g0594000 44.19(n)
    36.54(a)
      4336840  NM_001060260.1  NP_001053725.1 


    ENSEMBL Gene Tree for RNF14 (if available)
    TreeFam Gene Tree for RNF14 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RNF14 gene

    Find genes that share paralogs with RNF14           About GenesLikeMe


    4 Pseudogenes.org Pseudogenes for RNF14
    PGOHUM00000240359 PGOHUM00000245654 PGOHUM00000250891 PGOHUM00000233577


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RNF14 (see all 596)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1822952021,2
    --141344443(+) TGCCTC/TGGCCT 2 -- us2k10--------
    rs1865084211,2
    --141344457(+) AAAGGA/GCTGGG 2 -- us2k10--------
    rs1897153931,2
    --141344483(+) CACCAC/TGCCTG 2 -- us2k10--------
    rs762936151,2
    C--141344504(+) TTTTT-/TAAAAA 2 -- us2k10--------
    rs77287381,2
    C--141344510(+) TTTTTA/TTAAAA 2 -- us2k10--------
    rs2020362121,2
    --141344510(+) TTTTT-/ATAAAA 2 -- us2k10--------
    rs1645161,2
    C,F,A,H--141344511(-) TTTTTT/AAAAAA 2 -- us2k16Minor allele frequency- A:0.17NA WA 12
    rs2002001621,2
    --141344511(+) TTTTT-/AAAAAA 2 -- us2k10--------
    rs1902395601,2
    --141344512(+) TTTTTA/TAAAAA 2 -- us2k10--------
    rs1831975101,2
    --141344618(+) ACTTCC/TGTACT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for RNF14 (141337893 - 141369856 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RNF14:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv5036CNV Insertion18451855
    nsv511116CNV Complex20534489

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RNF14
    DNA2.0 Custom Variant and Variant Library Synthesis for RNF14

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605675    OMIM disorders: --

    1 disease for RNF14:    
    About MalaCards
    prostate cancer


    Find genes that share disorders with RNF14           About GenesLikeMe

    1 Novoseek inferred disease relationship for RNF14 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate cancer 52 4 17110431 (2), 11501969 (1), 10085091 (1)

    Genetic Association Database (GAD): RNF14

    Export disorders for RNF14 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RNF14 gene, integrated from 10 sources (see all 41):
    (articles sorted by number of sources associating them with RNF14)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of human prostate coactivator ARA54, a novel protein that associates with the androgen receptor. (PubMed id 10085091)1, 2, 3, 9 Kang H.-Y.... Chang C. (J. Biol. Chem. 1999)
    2. Isolation and characterization of a novel human gene (HFB30) which encodes a protein with a RING finger motif. (PubMed id 10320776)1, 2, 3 Ueki N.... Muramatsu M.-A. (Biochim. Biophys. Acta 1999)
    3. N-terminally extended human ubiquitin-conjugating enzymes (E2s) mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8. (PubMed id 11322894)1, 2, 9 Ito K.... Okano Y. (Eur. J. Biochem. 2001)
    4. Regulation of androgen receptor transcriptional activity and specificity by RNF6-induced ubiquitination. (PubMed id 19345326)1, 2 Xu K.... Qiu Y. (Cancer Cell 2009)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Selection system for genes encoding nuclear-targeted proteins. (PubMed id 9853615)1, 2 Ueki N.... Muramatsu M.-A. (Nat. Biotechnol. 1998)
    8. Suppression of androgen receptor transactivation and prostate cancer cell growth by heterogeneous nuclear ribonucleoprotein A1 via interaction with androgen receptor coregulator ARA54. (PubMed id 17110431)1, 9 Yang Z....Chang C. (Endocrinology 2007)
    9. Ring Finger Protein 14 is a new regulator of TCF/I^-catenin-mediated transcription and colon cancer cell survival. (PubMed id 23449499)1 Wu B....Waterman M.L. (EMBO Rep. 2013)
    10. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9604 HGNC: 10058 AceView: RNF14 Ensembl:ENSG00000013561 euGenes: HUgn9604
    ECgene: RNF14 H-InvDB: RNF14

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RNF14 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RNF14 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RNF14 gene:
    Search GeneIP for patents involving RNF14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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