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Aliases for RNF14 Gene

Aliases for RNF14 Gene

  • Ring Finger Protein 14 2 3
  • Androgen Receptor-Associated Protein 54 3 4
  • RING Finger Protein 14 4 5
  • ARA54 3 4
  • HFB30 3 4
  • Androgen Receptor Associated Protein 54 3
  • Triad2 Protein 4
  • HRIHFB2038 3
  • EC 6.3.2.- 4
  • TRIAD2 3

External Ids for RNF14 Gene

Previous GeneCards Identifiers for RNF14 Gene

  • GC05P141171
  • GC05P141929
  • GC05P141329
  • GC05P141374
  • GC05P141326
  • GC05P136489
  • GC05P141358
  • GC05P141402

Summaries for RNF14 Gene

Entrez Gene Summary for RNF14 Gene

  • The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Six alternatively spliced transcript variants encoding two distinct isoforms have been reported. [provided by RefSeq, Jan 2011]

GeneCards Summary for RNF14 Gene

RNF14 (Ring Finger Protein 14) is a Protein Coding gene. Diseases associated with RNF14 include prostate cancer. Among its related pathways are Immune System and Androgen receptor signaling pathway. GO annotations related to this gene include ligase activity and androgen receptor binding. An important paralog of this gene is RNF19A.

UniProtKB/Swiss-Prot for RNF14 Gene

  • Might act as an E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates, which could be nuclear proteins. Could play a role as a coactivator for androgen- and, to a lesser extent, progesterone-dependent transcription.

Gene Wiki entry for RNF14 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF14 Gene

Genomics for RNF14 Gene

Regulatory Elements for RNF14 Gene

Promoters for RNF14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RNF14 on UCSC Golden Path with GeneCards custom track

Genomic Location for RNF14 Gene

Chromosome:
5
Start:
141,958,328 bp from pter
End:
141,990,291 bp from pter
Size:
31,964 bases
Orientation:
Plus strand

Genomic View for RNF14 Gene

Genes around RNF14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF14 Gene

Proteins for RNF14 Gene

  • Protein details for RNF14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBS8-RNF14_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase RNF14
    Protein Accession:
    Q9UBS8
    Secondary Accessions:
    • A0AV26
    • A6NMR2
    • A8MTW5
    • B3KN72
    • B7ZLV2
    • D3DQE4
    • O94793
    • Q6IBV0

    Protein attributes for RNF14 Gene

    Size:
    474 amino acids
    Molecular mass:
    53837 Da
    Quaternary structure:
    • Interacts with the ubiquitin-conjugating enzymes UBE2E1 and UBE2E2. Interacts with AR/androgen receptor; testosterone- and RNF6-regulated it promotes AR transcriptional activity.

    Alternative splice isoforms for RNF14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNF14 Gene

Proteomics data for RNF14 Gene at MOPED

Post-translational modifications for RNF14 Gene

  • RING-type zinc finger-dependent and UBE2E2-dependent autoubiquitination.
  • Ubiquitination at Lys 372 and Lys 386
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RNF14 Gene

Domains & Families for RNF14 Gene

Gene Families for RNF14 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UBS8

UniProtKB/Swiss-Prot:

RNF14_HUMAN :
  • The N-terminal destruction box (D-box) acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.
  • Belongs to the RBR family. RNF14 subfamily.
  • Contains 1 IBR-type zinc finger.
Domain:
  • The N-terminal destruction box (D-box) acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.
  • The RING-type zinc finger is essential for the interaction with UBE2E2.
  • Contains 1 RWD domain.
Family:
  • Belongs to the RBR family. RNF14 subfamily.
Similarity:
  • Contains 1 IBR-type zinc finger.
  • Contains 2 RING-type zinc fingers.
genes like me logo Genes that share domains with RNF14: view

Function for RNF14 Gene

Molecular function for RNF14 Gene

GENATLAS Biochemistry:
RING finger protein 14,ubiquitously expressed
UniProtKB/Swiss-Prot Function:
Might act as an E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates, which could be nuclear proteins. Could play a role as a coactivator for androgen- and, to a lesser extent, progesterone-dependent transcription.

Enzyme Numbers (IUBMB) for RNF14 Gene

Gene Ontology (GO) - Molecular Function for RNF14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IEA --
GO:0016874 ligase activity IEA --
GO:0031624 ubiquitin conjugating enzyme binding IBA --
GO:0050681 androgen receptor binding IPI 19345326
genes like me logo Genes that share ontologies with RNF14: view
genes like me logo Genes that share phenotypes with RNF14: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RNF14

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNF14 Gene

Localization for RNF14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF14 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNF14 Gene COMPARTMENTS Subcellular localization image for RNF14 gene
Compartment Confidence
nucleus 5
cytosol 3

No data available for Gene Ontology (GO) - Cellular Components for RNF14 Gene

Pathways & Interactions for RNF14 Gene

genes like me logo Genes that share pathways with RNF14: view

UniProtKB/Swiss-Prot Q9UBS8-RNF14_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for RNF14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IDA 19345326
GO:0016567 protein ubiquitination IEP 11322894
GO:0030521 androgen receptor signaling pathway NAS 11322894
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA --
GO:0045893 positive regulation of transcription, DNA-templated NAS 15572661
genes like me logo Genes that share ontologies with RNF14: view

No data available for SIGNOR curated interactions for RNF14 Gene

Drugs & Compounds for RNF14 Gene

(2) Drugs for RNF14 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with RNF14: view

Transcripts for RNF14 Gene

Unigene Clusters for RNF14 Gene

Ring finger protein 14:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNF14 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b ^ 10 ^
SP1: - -
SP2:
SP3: - - - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - -
SP6: - - -
SP7: - - - - - - - - - - - - - -
SP8: - - - - - - - - -
SP9: - - - - - - - -
SP10: - - - - - - -
SP11: - - - - - - - - - -
SP12: - - - - - - - - - - - - -
SP13: - - -
SP14: - - - - - - - - - -
SP15: -
SP16: - - - - - - - - - - - -
SP17: - - - - - - - -
SP18: - - - - - - - -
SP19: - - -
SP20: - - - - - -

ExUns: 11a · 11b · 11c ^ 12a · 12b ^ 13a · 13b · 13c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:

Relevant External Links for RNF14 Gene

GeneLoc Exon Structure for
RNF14
ECgene alternative splicing isoforms for
RNF14

Expression for RNF14 Gene

mRNA expression in normal human tissues for RNF14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RNF14 Gene

This gene is overexpressed in Testis (11.9), Skin (7.1), and Peripheral blood mononuclear cells (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RNF14 Gene



SOURCE GeneReport for Unigene cluster for RNF14 Gene Hs.483616

mRNA Expression by UniProt/SwissProt for RNF14 Gene

Q9UBS8-RNF14_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with RNF14: view

Protein tissue co-expression partners for RNF14 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for RNF14 Gene

Orthologs for RNF14 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RNF14 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RNF14 35
  • 94.16 (n)
  • 95.78 (a)
RNF14 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNF14 35
  • 93.74 (n)
  • 95.78 (a)
RNF14 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnf14 35
  • 87.97 (n)
  • 90.51 (a)
Rnf14 16
Rnf14 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RNF14 35
  • 99.65 (n)
  • 99.79 (a)
RNF14 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnf14 35
  • 88.68 (n)
  • 91.98 (a)
oppossum
(Monodelphis domestica)
Mammalia RNF14 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RNF14 36
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves RNF14 36
  • 77 (a)
OneToMany
RNF14 36
  • 77 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia RNF14 36
  • 72 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.3688 35
zebrafish
(Danio rerio)
Actinopterygii rnf14 36
  • 58 (a)
OneToMany
RNF14 (1 of 5) 36
  • 54 (a)
OneToMany
RNF14 (3 of 5) 36
  • 54 (a)
OneToMany
RNF14 (4 of 5) 36
  • 58 (a)
OneToMany
RNF14 (5 of 5) 36
  • 58 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F56D2.2 37
  • 28 (a)
F56D2.5 37
  • 30 (a)
F56D2.2 36
  • 18 (a)
OneToMany
F56D2.5 36
  • 22 (a)
OneToMany
Y57A10A.31 36
  • 7 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ITT1 36
  • 14 (a)
OneToOne
ITT1 38
rice
(Oryza sativa)
Liliopsida Os04g0594000 35
  • 44.19 (n)
  • 36.54 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
OneToOne
Species with no ortholog for RNF14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RNF14 Gene

ENSEMBL:
Gene Tree for RNF14 (if available)
TreeFam:
Gene Tree for RNF14 (if available)

Paralogs for RNF14 Gene

Paralogs for RNF14 Gene

Pseudogenes.org Pseudogenes for RNF14 Gene

genes like me logo Genes that share paralogs with RNF14: view

Variants for RNF14 Gene

Sequence variations from dbSNP and Humsavar for RNF14 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs3087 -- 141,987,977(-) AACTT(A/G)CATTT utr-variant-3-prime
rs10873 -- 141,988,913(-) ACCCA(A/G)AAAAA utr-variant-3-prime
rs187542 -- 141,974,655(-) AACTT(C/G)GTAGC intron-variant
rs187543 -- 141,969,069(-) GCTGG(C/T)GCGAC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs187544 -- 141,965,796(-) gcccc(A/C)gtgtg upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RNF14 Gene

Variant ID Type Subtype PubMed ID
nsv511116 CNV Complex 20534489
nsv5036 CNV Insertion 18451855

Variation tolerance for RNF14 Gene

Residual Variation Intolerance Score: 25.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.22; 24.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNF14 Gene

HapMap Linkage Disequilibrium report
RNF14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF14 Gene

Disorders for RNF14 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RNF14 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
prostate cancer
  • prostate cancer, hereditary, 5
- elite association - COSMIC cancer census association via MalaCards
Search RNF14 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RNF14

Genetic Association Database (GAD)
RNF14
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RNF14
genes like me logo Genes that share disorders with RNF14: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RNF14 Gene

Publications for RNF14 Gene

  1. Cloning and characterization of human prostate coactivator ARA54, a novel protein that associates with the androgen receptor. (PMID: 10085091) Kang H.-Y. … Chang C. (J. Biol. Chem. 1999) 2 3 4 23 67
  2. Suppression of androgen receptor transactivation and prostate cancer cell growth by heterogeneous nuclear ribonucleoprotein A1 via interaction with androgen receptor coregulator ARA54. (PMID: 17110431) Yang Z. … Chang C. (Endocrinology 2007) 3 23
  3. N-terminally extended human ubiquitin-conjugating enzymes (E2s) mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8. (PMID: 11322894) Ito K. … Okano Y. (Eur. J. Biochem. 2001) 3 23
  4. Isolation and characterization of a novel human gene (HFB30) which encodes a protein with a RING finger motif. (PMID: 10320776) Ueki N. … Muramatsu M.-A. (Biochim. Biophys. Acta 1999) 2 3
  5. The von hippel-lindau protein suppresses androgen receptor activity. (PMID: 24422631) Wang J. … Xiao W. (Mol. Endocrinol. 2014) 3

Products for RNF14 Gene

Sources for RNF14 Gene

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