Aliases for RNF139 Gene
External Ids for RNF139 Gene
Previous GeneCards Identifiers for RNF139 Gene
The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP. [provided by RefSeq, Jul 2008]
GeneCards Summary for RNF139 Gene
RNF139 (Ring Finger Protein 139) is a Protein Coding gene. Diseases associated with RNF139 include hereditary clear cell renal cell carcinoma and hereditary renal cell carcinoma. Among its related pathways are Regulation of cholesterol biosynthesis by SREBP (SREBF). GO annotations related to this gene include ligase activity and receptor activity. An important paralog of this gene is RNF145.
UniProtKB/Swiss-Prot for RNF139 Gene
E3-ubiquitin ligase; acts as a negative regulator of the cell proliferation through mechanisms involving G2/M arrest and cell death. Required for MHC class I ubiquitination in cells expressing the cytomegalovirus protein US2 before dislocation from the endoplasmic reticulum (ER). Affects SREBP processing by hindering the SREBP/SCAP complex translocation from the ER to the Golgi, thereby reducing SREBF2 target gene expression. Required for INSIG1 ubiquitination. May be required for EIF3 complex ubiquitination. May function as a signaling receptor.