RNF139 Gene
protein-coding GIFtS: 51
GCID: GC08P125487
|
|
ring finger protein 139
| |
Aliases
for RNF139 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ring Finger Protein 1391 2 3 | | E3 Ubiquitin-Protein Ligase RNF1392 | | TRC81 2 3 5 | | Multiple Membrane Spanning Receptor TRC82 | | RCA11 2 5 | | Patched Related Protein Translocated In Renal Cancer2 | | HRCA11 2 | | EC 6.3.2.-3 | | Translocation In Renal Carcinoma On Chromosome 8 Protein2 3 | | |
Export aliases for RNF139 gene to outside databasesPrevious GC identifers: GC08P125155 GC08P125443 GC08P125556 GC08P120812 |
Summaries
for RNF139 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RNF139:
The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein islocated in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found tobe interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies ofthe Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as withCOPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP. (provided by RefSeq, Jul2008)
UniProtKB/Swiss-Prot: RN139_HUMAN, Q8WU17Function: E3-ubiquitin ligase; acts as a negative regulator of the cell proliferation through mechanisms involving G2/Marrest and cell death. Required for MHC class I ubiquitination in cells expressing the cytomegalovirus protein US2before dislocation from the endoplasmic reticulum (ER). Affects SREBP processing by hindering the SREBP/SCAP complextranslocation from the ER to the Golgi, thereby reducing SREBF2 target gene expression. Required for INSIG1ubiquitination. May be required for EIF3 complex ubiquitination. May function as a signaling receptor
Gene Wiki entry for RNF139
|
Genomic Views
for RNF139 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_008046.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RNF139 gene promoter:
Nkx3-1 v2 Nkx3-1 RORalpha1 Nkx3-1 v4 Pax-6 Nkx3-1 v3 Nkx3-1 v1 POU3F2 GATA-1 Evi-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for RNF139
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF139 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q24 Ensembl cytogenetic band: 8q24.13 HGNC cytogenetic band: 8q24RNF139 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08P125487: view genomic region
(about GC identifiers)
Start:
|
125,486,979 bp from pter |
End:
|
125,500,859 bp from pter |
Size:
|
13,881 bases |
Orientation:
|
plus strand |
|
Proteins
for RNF139 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RN139_HUMAN, Q8WU17 (See
protein sequence)Recommended Name: E3 ubiquitin-protein ligase RNF139 Size: 664 amino acids; 75994 Da
Subunit: Interacts with VHL. Interacts with MHC class I and HM13. Component of SCAP/SREBP complex composed of SREBF2,SCAP and RNF139; the complex hampers the interaction between SCAP and SEC24B, thereby reducing SREBF2 proteolyticprocessing. Interacts with SREBF2 (via C-terminus domain). Interacts with SCAP; the interaction inhibits theinteraction of SCAP with SEC24B and hampering the ER to Golgi transport of the SCAP/SREBP complex. Interacts withSEC24B. Interacts with INSIG1 and INSIG2. Interacts with EIF3F and EIF3H; the interaction leads to protein translationinhibitions in a ubiquitination-dependent manner
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein
Secondary accessions: B3KMD5 O75485 Q7LDL3Explore the universe of human proteins at neXtProt for RNF139: NX_Q8WU17
Post-translational modifications:
Autoubiquitinated. Ubiquitination is induced by sterol and leads to ist degradation via the ubiquitin-proteasomepathway1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8WU17
RNF139 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_009149.2
ENSEMBL proteins: ENSP00000304051 ENSP00000429836
Human Recombinant Protein Products for RNF139:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
RNF139 for ontologies About GeneDecksing
RNF139 Antibody Products:
Assay Products for RNF139: |
Protein
Domains /
Families
for RNF139 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RNF139 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8WU17ProtoNet protein and cluster: Q8WU17 1 Blocks protein family: IPB001841 Zn-finger
UniProtKB/Swiss-Prot: RN139_HUMAN, Q8WU17Domain: The RING-type zinc finger domain mediates ubiquitin ligase activitySimilarity: Contains 1 RING-type zinc finger |
Function
for RNF139 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: RN139_HUMAN, Q8WU17Function: E3-ubiquitin ligase; acts as a negative regulator of the cell proliferation through mechanisms involving G2/Marrest and cell death. Required for MHC class I ubiquitination in cells expressing the cytomegalovirus protein US2before dislocation from the endoplasmic reticulum (ER). Affects SREBP processing by hindering the SREBP/SCAP complextranslocation from the ER to the Golgi, thereby reducing SREBF2 target gene expression. Required for INSIG1ubiquitination. May be required for EIF3 complex ubiquitination. May function as a signaling receptorInduction: Down-regulated by sterols (at protein level) Enzyme Number (IUBMB): EC 6.3.2.-1
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
RNF139 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF139 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF139
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RNF139 (NM_007218) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RNF139 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF139 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF139 |
|
Pathways & Interactions
for RNF139 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
UniProtKB/Swiss-Prot: RN139_HUMAN, Q8WU17Pathway: Protein modification; protein ubiquitinationInteractions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNF139
STRING Interaction
Network Preview (showing 5 interactants - click image to see 20)
5/20 Interacting proteins for RNF139 (Q8WU171, 3 ENSP000003040514) via UniProtKB, MINT, STRING, and/or I2D (see all 20) About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table
RNF139 for ontologies About GeneDecksing
|
Drugs & Compounds
for RNF139 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RNF139
Search CenterWatch for drugs/clinical trials and news about RNF139 / RN139
|
Transcripts
for RNF139 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RNF139 gene: NM_007218.3 Unigene Cluster for RNF139: Ring finger protein 139 Hs.744151 [show with all ESTs]Unigene Representative Sequence: NM_0072182 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000303545(uc003yrc.3) ENST00000517684
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF139 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF139
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RNF139 (NM_007218) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RNF139 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF139 |
Additional cDNA sequence: AF064801.1 AK001602.1 AK025043.1 AK098519.1 BC021571.1 BC064636.1 7 DOTS entries: DT.453008 DT.99960535 DT.213432 DT.100772805 DT.100772808 DT.452925 DT.95367087 24/130 AceView cDNA sequences (see all 130): BE219019 Z41531 AK098519 CR622053 AA558801 NM_007218 BG505335 BQ014422 BG430138 AK025043 AU130820 BQ014830 BC064636 BC021571 AW009775 AL541293 AF064801 AI480084 AL529504 CR614013 AL041427 BM919013 AI339360 AI802271
GeneLoc Exon Structure
|
Expression
for RNF139 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RNF139 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CACTTTGCCT
About this image
See RNF139 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RNF139
SOURCE GeneReport for Unigene cluster: Hs.744151
UniProtKB/Swiss-Prot: RN139_HUMAN, Q8WU17Tissue specificity: Highly expressed in testis, placenta and adrenal gland. Moderate expression in heart, brain, liver,skeletal muscle and pancreas, and low expression in lung and kidney
SABiosciences Expression via Pathway-Focused PCR Arrays including RNF139:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNF139
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RNF139 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNF139 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNF139 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF139 |
Orthologs
for RNF139 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for RNF139 gene from 5/20 species (see all 20) About this table
ENSEMBL Gene Tree for RNF139 (if available)
TreeFam Gene Tree for RNF139 (if available) |
Paralogs
for RNF139 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RNF139 gene
- SYVN12 AMFR2 RNF1452
RNF139 for paralogs About GeneDecksing
|
Genomic Variants
for RNF139 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RNF139 (125486979 - 125500859 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for RNF139
1 Indel: 100491
Human Gene Mutation Database (HGMD): RNF139
| SABiosciences Cancer Mutation PCR Assays |
| 1 SABiosciences qBiomarker Copy Number PCR Array containing RNF139: |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNF139 |
|
Disorders
/ Diseases
for RNF139 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RNF139 for disorders About GeneDecksing
OMIM gene information: 603046
OMIM disorders: 144700
UniProtKB/Swiss-Prot: RN139_HUMAN, Q8WU17
Defects in RNF139 may be a cause of renal cell carcinoma (RCC) [MIM:144700]. It is a heterogeneous group ofsporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified intoclear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cellcarcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma.Note=A chromosomal aberration involving RNF139 has been found in a lymphoblastoid cell line established from a familywith renal cell carcinoma and thyroid carcinoma. Translocation (3;8)(q14.2;q24.1) with FHIT. RNF139 is found to befused to FHIT and disrupted within the sterol-sensing domain. In contrast, the FHIT coding region is maintained andexpressed. Sporadic cases of renal carcinoma, where an acquired mutation in RNF139 results in the duplication of 12nucleotides in the 5'-UTR, has also been identified
15  diseases for RNF139: About MalaCardsrenal carcinoma renal cell carcinoma carcinoma collecting duct carcinoma
thyroiditis clear cell renal cell carcinoma chromophobe renal cell carcinoma papillary renal cell carcinoma
hereditary renal cell carcinoma familial renal cell carcinoma thyroid cancer dysgerminoma
kidney cancer encephalitis thyroid carcinoma
1 disease from the University of Copenhagen DISEASES database for RNF139:Kidney cancer Export disorders for RNF139 gene to outside databases
|
Publications
for RNF139 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RNF139 gene, integrated from 9 sources (see all 23):
(articles sorted by number of sources associating them with RNF139) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched-related gene, TRC8. (PubMed id 9689122)1, 2, 3, 9 Gemmill R.M.... Drabkin H.A. (1998)
- The TRC8 ubiquitin ligase is sterol regulated and int eracts with lipid and protein biosynthetic pathways. (PubMed id 20068067)1, 2, 9 Lee J.P....Gemmill R.M. (2010)
- The TRC8 E3 ligase ubiquitinates MHC class I molecule s before dislocation from the ER. (PubMed id 19720873)1, 2, 9 Stagg H.R....Lehner P.J. (2009)
- RING-dependent tumor suppression and G2/M arrest induced by the TRC8 hereditary kidney cancer gene. (PubMed id 17016439)1, 2, 9 Brauweiler A....Gemmill R.M. (2007)
- The sterol-sensing endoplasmic reticulum (ER) membran e protein TRC8 hampers ER to Golgi transport of sterol regulatory element-bindi ng protein-2 (SREBP-2)/SREBP cleavage-activated protein and reduces SREBP-2 cle avage. (PubMed id 19706601)1, 2 Irisawa M....Sato R. (2009)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The TRC8 hereditary kidney cancer gene suppresses growth and functions with VHL in a common pathway. (PubMed id 12032852)1, 2 Gemmill R.M.... Drabkin H.A. (2002)
- RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination. (PubMed id 10500182)1, 2 Lorick K.L....Weissman A.M. (1999)
|
External Searches for RNF139 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RNF139 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RNF139 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RNF139 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for RNF139 gene:
Search GeneIP for patents involving RNF139
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RNF139 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for RNF139 | | OriGene shRNA RFP for RNF139 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RNF139 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNF139 | | | OriGene Protein Over-expression Lysate for RNF139 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RNF139 | | OriGene 3'-UTR Clone for RNF139 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF139 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF139 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RNF139 | | OriGene Custom Protein Services for RNF139 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RNF139 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNF139 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF139 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNF139 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNF139 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNF139 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for RNF139 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | RNF139 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF139 |
|  |  |  |  | | | | ThermoFisher Antibodies for RNF139 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF139 |
| |  | |
|
|
|
