Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



RNF139 Gene

protein-coding   GIFtS: 52
GCID: GC08P125487

Ring Finger Protein 139

  See RNF139-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Ring Finger Protein 1391 2 3     E3 Ubiquitin-Protein Ligase RNF1392
TRC82 3 5     Multiple Membrane Spanning Receptor TRC82
Translocation In Renal Carcinoma On Chromosome 8 Protein2 3     Patched Related Protein Translocated In Renal Cancer2
RCA12 5     EC 6.3.2.-3
HRCA12     

External Ids:    HGNC: 170231   Entrez Gene: 112362   Ensembl: ENSG000001708817   OMIM: 6030465   UniProtKB: Q8WU173   

Export aliases for RNF139 gene to outside databases

Previous GC identifers: GC08P125155 GC08P125443 GC08P125556 GC08P120812


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for RNF139 Gene:
The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is
located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was
found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid
cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor
protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor
CDKN1B/P27KIP. (provided by RefSeq, Jul 2008)

GeneCards Summary for RNF139 Gene:
RNF139 (ring finger protein 139) is a protein-coding gene. Diseases associated with RNF139 include kidney cancer, and hereditary renal cell carcinoma. GO annotations related to this gene include ubiquitin-protein ligase activity and ligase activity. An important paralog of this gene is SYVN1.

UniProtKB/Swiss-Prot: RN139_HUMAN, Q8WU17
Function: E3-ubiquitin ligase; acts as a negative regulator of the cell proliferation through mechanisms involving
G2/M arrest and cell death. Required for MHC class I ubiquitination in cells expressing the cytomegalovirus
protein US2 before dislocation from the endoplasmic reticulum (ER). Affects SREBP processing by hindering the
SREBP/SCAP complex translocation from the ER to the Golgi, thereby reducing SREBF2 target gene expression.
Required for INSIG1 ubiquitination. May be required for EIF3 complex ubiquitination. May function as a signaling
receptor

Gene Wiki entry for RNF139 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Regulatory transcription factor binding sites in the RNF139 gene promoter:
         Nkx3-1 v2   Nkx3-1   RORalpha1   Nkx3-1 v4   Pax-6   Nkx3-1 v3   Nkx3-1 v1   POU3F2   GATA-1   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNF139 promoter sequence
   Search Chromatin IP Primers for RNF139

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNF139


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24   Ensembl cytogenetic band:  8q24.13   HGNC cytogenetic band: 8q24

RNF139 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF139 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P125487:  view genomic region     (about GC identifiers)

Start:
125,486,979 bp from pter      End:
125,500,859 bp from pter
Size:
13,881 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: RN139_HUMAN, Q8WU17 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase RNF139  
Size: 664 amino acids; 75994 Da
Subunit: Interacts with VHL. Interacts with MHC class I and HM13. Component of SCAP/SREBP complex composed of
SREBF2, SCAP and RNF139; the complex hampers the interaction between SCAP and SEC24B, thereby reducing SREBF2
proteolytic processing. Interacts with SREBF2 (via C-terminus domain). Interacts with SCAP; the interaction
inhibits the interaction of SCAP with SEC24B and hampering the ER to Golgi transport of the SCAP/SREBP complex.
Interacts with SEC24B. Interacts with INSIG1 and INSIG2. Interacts with EIF3F and EIF3H; the interaction leads to
protein translation inhibitions in a ubiquitination-dependent manner
Secondary accessions: B3KMD5 O75485 Q7LDL3

Explore the universe of human proteins at neXtProt for RNF139: NX_Q8WU17

Explore proteomics data for RNF139 at MOPED

Post-translational modifications: 

  • Autoubiquitinated. Ubiquitination is induced by sterol and leads to ist degradation via the ubiquitin-proteasome
    pathway1
  • Ubiquitination2 at Lys574
  • Modification sites at PhosphoSitePlus

  • See RNF139 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_009149.2  
    ENSEMBL proteins: 
     ENSP00000304051   ENSP00000429836  

    RNF139 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for RNF139
    OriGene Custom MassSpec
    OriGene Custom Protein Services for RNF139
    GenScript Custom Purified and Recombinant Proteins Services for RNF139
    Novus Biologicals RNF139 Proteins
    Novus Biologicals RNF139 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RNF139

     
    Search eBioscience for Proteins for RNF139 

     
    antibodies-online proteins for RNF139 (4 products) 

     
    antibodies-online peptides for RNF139

    RNF139 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for RNF139
    OriGene Custom Antibody Services for RNF139
    Novus Biologicals RNF139 Antibodies
    Abcam antibodies for RNF139
    Cloud-Clone Corp. Antibodies for RNF139
    ThermoFisher Antibodies for RNF139
    antibodies-online antibodies for RNF139 (33 products) 

    RNF139 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RNF139
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RNF139
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RNF139
    Cloud-Clone Corp. CLIAs for RNF139
    Search eBioscience for ELISAs for RNF139 
    antibodies-online kits for RNF139 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers

    3 InterPro protein domains:
     IPR001841 Znf_RING
     IPR025754 TRC8_N_dom
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q8WU17

    ProtoNet protein and cluster: Q8WU17

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: RN139_HUMAN, Q8WU17
    Domain: The RING-type zinc finger domain mediates ubiquitin ligase activity
    Similarity: Contains 1 RING-type zinc finger


    Find genes that share domains with RNF139           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RN139_HUMAN, Q8WU17
    Function: E3-ubiquitin ligase; acts as a negative regulator of the cell proliferation through mechanisms involving
    G2/M arrest and cell death. Required for MHC class I ubiquitination in cells expressing the cytomegalovirus
    protein US2 before dislocation from the endoplasmic reticulum (ER). Affects SREBP processing by hindering the
    SREBP/SCAP complex translocation from the ER to the Golgi, thereby reducing SREBF2 target gene expression.
    Required for INSIG1 ubiquitination. May be required for EIF3 complex ubiquitination. May function as a signaling
    receptor
    Induction: Down-regulated by sterols (at protein level)

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IMP19720873
    GO:0004872receptor activity TAS9689122
    GO:0005515protein binding IPI12032852
    GO:0008270zinc ion binding IEA--
    GO:0016874ligase activity TAS10500182
         
    Find genes that share ontologies with RNF139           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for RNF139

    miRNA
    Products:
        
    miRTarBase miRNAs that target RNF139:
    hsa-mir-423-5p (MIRT038108)

    Block miRNA regulation of human, mouse, rat RNF139 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RNF139 (see all 35):
    hsa-miR-136 hsa-miR-513a-5p hsa-miR-4272 hsa-miR-875-5p hsa-miR-128 hsa-miR-218 hsa-miR-570 hsa-miR-10b*
    SwitchGear 3'UTR luciferase reporter plasmidRNF139 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RNF139
    Predesigned siRNA for gene silencing in human, mouse, rat RNF139

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RNF139

    Clone
    Products:
         
    OriGene clones in human, mouse for RNF139 (see all 6)
    OriGene ORF clones in mouse, rat for RNF139
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RNF139 (NM_007218)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNF139
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF139

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RNF139
    Browse ESI BIO Cell Lines and PureStem Progenitors for RNF139 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF139


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    RN139_HUMAN, Q8WU17: Endoplasmic reticulum membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    plasma membrane3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA12032852
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral component of membrane TAS12032852

    Find genes that share ontologies with RNF139           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for RNF139 About    
    See pathways by source

    SuperPathContained pathways About
    1Regulation of Cholesterol Biosynthesis by SREBP (SREBF)
    SREBP signalling0.31


    1 BioSystems Pathway for RNF139
        SREBP signalling


    UniProtKB/Swiss-Prot: RN139_HUMAN, Q8WU17
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Arrays including RNF139: 

              Unfolded Protein Response in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for RNF139

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RNF139 (Q8WU171, 3 ENSP000003040514) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    VHLP403371, 3, ENSP000002564744EBI-1551681,EBI-301246 I2D: score=3 STRING: ENSP00000256474
    COPS5Q929053, ENSP000003505124I2D: score=5 STRING: ENSP00000350512
    UBE2UQ5VVX93, ENSP000003601164I2D: score=2 STRING: ENSP00000360116
    EIF3FO003033, ENSP000003100404I2D: score=1 STRING: ENSP00000310040
    EIF3HO153723, ENSP000002766824I2D: score=1 STRING: ENSP00000276682
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008285negative regulation of cell proliferation IDA17016439
    GO:0016567protein ubiquitination IMP19720873
    GO:0017148negative regulation of translation IDA--
    GO:0031396regulation of protein ubiquitination IDA10500182
    GO:0060628regulation of ER to Golgi vesicle-mediated transport IDA19706601

    Find genes that share ontologies with RNF139           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RNF139 (RN139)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for RNF139 gene: 
    NM_007218.3  

    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000303545(uc003yrc.3) ENST00000517684
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RNF139 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RNF139 (see all 35):
    hsa-miR-136 hsa-miR-513a-5p hsa-miR-4272 hsa-miR-875-5p hsa-miR-128 hsa-miR-218 hsa-miR-570 hsa-miR-10b*
    SwitchGear 3'UTR luciferase reporter plasmidRNF139 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RNF139
    Predesigned siRNA for gene silencing in human, mouse, rat RNF139
    Clone
    Products:
         
    OriGene clones in human, mouse for RNF139 (see all 6)
    OriGene ORF clones in mouse, rat for RNF139
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RNF139 (NM_007218)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNF139
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF139
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RNF139
    OriGene qSTAR qPCR primer pairs in human, mouse for RNF139
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RNF139
      QuantiTect SYBR Green Assays in human, mouse, rat RNF139
      QuantiFast Probe-based Assays in human, mouse, rat RNF139

    Selected AceView cDNA sequences (see all 130):

    AK025043 BG430138 BI765465 AW009775 CR622053 NM_007218 BQ014830 BC064636 
    AI480084 AK098519 BM668717 AA127767 BG505335 AK001602 CR614013 AI362010 
    BM693442 AU130820 AI308198 AA558801 BE219019 AF064801 BM919013 BC021571 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    RNF139 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACTTTGCCT
    RNF139 Expression
    About this image


    RNF139 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Testis (Reproductive System)
    RNF139 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RNF139 Protein Expression

    UniProtKB/Swiss-Prot: RN139_HUMAN, Q8WU17
    Tissue specificity: Highly expressed in testis, placenta and adrenal gland. Moderate expression in heart, brain,
    liver, skeletal muscle and pancreas, and low expression in lung and kidney

        Pathway & Disease-focused RT2 Profiler PCR Arrays including RNF139: 
              Unfolded Protein Response in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RNF139
    OriGene qSTAR qPCR primer pairs in human, mouse for RNF139
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RNF139
    QuantiTect SYBR Green Assays in human, mouse, rat RNF139
    QuantiFast Probe-based Assays in human, mouse, rat RNF139
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF139

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RNF139 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnf1391 , 5 ring finger protein 1391, 5 91.57(n)1
    93.67(a)1
      15 (25.09 cM)5
    758411  NM_175226.41  NP_780435.11 
     588892295 
    chicken
    (Gallus gallus)
    Aves RNF1391 ring finger protein 139 74.95(n)
    79.73(a)
      420338  NM_001030955.1  NP_001026126.1 
    lizard
    (Anolis carolinensis)
    Reptilia RNF1396
    ring finger protein 139
    76(a)
    1 ↔ 1
    4(6276458-6289256)
    African clawed frog
    (Xenopus laevis)
    Amphibia BX852394.12   -- 73.25(n)    BX852394.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rnf1391 ring finger protein 139 62.07(n)
    68.68(a)
      100144552  NM_001123048.1  NP_001116520.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Trc81 Trc8 50.23(n)
    46.3(a)
      43476  NM_206580.2  NP_996303.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HRD16
    Ubiquitin-protein ligase required for endoplasmic ...
    13(a)
    1 → many
    XV(301380-303035) YOL013C


    ENSEMBL Gene Tree for RNF139 (if available)
    TreeFam Gene Tree for RNF139 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for RNF139 gene
    SYVN12  AMFR2  RNF1452  

    Find genes that share paralogs with RNF139           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for RNF139 (see all 303)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3721902451,2
    C--125490846(+) TGTCT-/AAAAAA 1 -- int10--------
    rs1999115451,2
    C--125490964(+) TTTTT-/TGAGAC 1 -- int10--------
    rs113547781,2
    C--125492381(+) CTCTTA/-AAAAA 1 -- int1 trp31Minor allele frequency- -:0.00NA 2
    rs346616211,2
    C--125492646(+) AAAAA-/AAAAAA 1 -- int11Minor allele frequency- A:0.00NA 2
    rs784562041,2
    F--125495234(+) ATTTAT/AAAATA 1 -- int11Minor allele frequency- A:0.50NA 4
    rs3725962591,2
    C--125495264(+) TATATA/TTTAAA 1 -- int10--------
    rs719164401,2
    C--125495294(+) TATAT-/CTATTA 1 -- int10--------
    rs769047991,2
    F--125495332(+) TATATT/ATTTAA 1 -- int12Minor allele frequency- A:0.50NA 6
    rs795522911,2
    F--125495339(+) TTAAAT/AATATA 1 -- int12Minor allele frequency- A:0.33NA 6
    rs1415881481,2
    C--125759794(+) TTGCCA/CCTGCT 1 -- int10--------

    HapMap Linkage Disequilibrium report for RNF139 (125486979 - 125500859 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for RNF139:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1307e199CNV Deletion23128226
    esv2660702CNV Deletion23128226
    esv1584427CNV Insertion17803354
    esv2523354CNV Insertion19546169
    nsv824727CNV Loss20364138
    dgv7874n71CNV Gain21882294

    Human Gene Mutation Database (HGMD): RNF139
    Site Specific Mutation Identification with PCR Assays
    1 Copy Number PCR Panel containing RNF139:
    Ovarian Cancer
    SeqTarget long-range PCR primers for resequencing RNF139
    DNA2.0 Custom Variant and Variant Library Synthesis for RNF139

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 603046   
    OMIM disorders: 144700  
    UniProtKB/Swiss-Prot: RN139_HUMAN, Q8WU17
  • Renal cell carcinoma (RCC) [MIM:144700]: Renal cell carcinoma is a heterogeneous group of sporadic or
    hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear
    cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma,
    collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma. Clear
    cell renal cell carcinoma is the most common subtype. Note=The disease may be caused by mutations affecting the
    gene represented in this entry. A chromosomal aberration involving RNF139 has been found in a lymphoblastoid cell
    line established from a family with renal cell carcinoma and thyroid carcinoma. Translocation (3;8)(q14.2;q24.1)
    with FHIT. RNF139 is found to be fused to FHIT and disrupted within the sterol-sensing domain. In contrast, the
    FHIT coding region is maintained and expressed. Sporadic cases of renal carcinoma, where an acquired mutation in
    RNF139 results in the duplication of 12 nucleotides in the 5'-UTR, has also been identified

  • 6 diseases for RNF139:    
    About MalaCards
    kidney cancer    hereditary renal cell carcinoma    thyroid cancer    clear cell renal cell carcinoma
    familial renal cell carcinoma    renal cell carcinoma

    1 disease from the University of Copenhagen DISEASES database for RNF139:
    Kidney cancer

    Find genes that share disorders with RNF139           About GenesLikeMe


    Export disorders for RNF139 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for RNF139 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with RNF139)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched-related gene, TRC8. (PubMed id 9689122)1, 2, 3, 9 Gemmill R.M.... Drabkin H.A. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    2. The TRC8 ubiquitin ligase is sterol regulated and interacts with lipid and protein biosynthetic pathways. (PubMed id 20068067)1, 2, 9 Lee J.P....Gemmill R.M. (Mol. Cancer Res. 2010)
    3. The TRC8 E3 ligase ubiquitinates MHC class I molecules before dislocation from the ER. (PubMed id 19720873)1, 2, 9 Stagg H.R.... Lehner P.J. (J. Cell Biol. 2009)
    4. RING-dependent tumor suppression and G2/M arrest induced by the TRC8 hereditary kidney cancer gene. (PubMed id 17016439)1, 2, 9 Brauweiler A.... Gemmill R.M. (Oncogene 2007)
    5. The sterol-sensing endoplasmic reticulum (ER) membrane protein TRC8 hampers ER to Golgi transport of sterol regulatory element-binding protein-2 (SREBP-2)/SREBP cleavage-activated protein and reduces SREBP-2 cleavage. (PubMed id 19706601)1, 2 Irisawa M.... Sato R. (J. Biol. Chem. 2009)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. The TRC8 hereditary kidney cancer gene suppresses growth and functions with VHL in a common pathway. (PubMed id 12032852)1, 2 Gemmill R.M.... Drabkin H.A. (Oncogene 2002)
    10. RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination. (PubMed id 10500182)1, 2 Lorick K.L....Weissman A.M. (Proc. Natl. Acad. Sci. U.S.A. 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 11236 HGNC: 17023 AceView: RNF139 Ensembl:ENSG00000170881 euGenes: HUgn11236
    ECgene: RNF139 H-InvDB: RNF139

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for RNF139 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RNF139 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for RNF139 gene:
    Search GeneIP for patents involving RNF139

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for RNF139   OriGene RNAi products in human, mouse, rat for RNF139  
     OriGene qPCR primer pairs and template standards for RNF139   OriGene Protein Over-expression Lysate for RNF139  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for RNF139  
     OriGene qSTAR qPCR primer pairs in human, mouse for RNF139   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for RNF139   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RNF139   OriGene Custom Protein Services for RNF139  

     
     
     Block miRNA regulation of human, mouse, rat RNF139 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing RNF139
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNF139 Predesigned siRNA for gene silencing in human, mouse, rat RNF139
     QuantiFast Probe-based Assays in human, mouse, rat RNF139 QuantiTect SYBR Green Assays in human, mouse, rat RNF139
     PCR Arrays including human, mouse, rat RNF139 Search Chromatin IP Primers for RNF139
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RNF139  Search GeneGlobe Interaction Network for RNF139
     Regulatory tfbs in RNF139 promoter
     GenScript Custom Purified and Recombinant Proteins Services for RNF139 GenScript cDNA clones with any tag delivered in your preferred vector for RNF139
     GenScript Custom Assay Services for RNF139 GenScript Custom overexpressing Cell Line Services for RNF139
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for RNF139 (RN139)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     RNF139 antibodies
     RNF139 proteins
     RNF139 lysates
     Antibodies for RNF139
     See all of Abcam's Antibodies, Kits and Proteins for RNF139
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for RNF139
     Antibodies for RNF139
     ELISAs for RNF139
     CLIAs for RNF139



     Browse ESI BIO Cell Lines and PureStem Progenitors for RNF139
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF139
     SwitchGear 3'UTR luciferase reporter plasmids for RNF139
     SwitchGear Promoter luciferase reporter plasmids for RNF139
     ThermoFisher Antibodies for RNF139
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF139
     Browse compounds at ApexBio
     Search Addgene for plasmids for RNF139
      Search eBioscience for proteins for RNF139
      Search eBioscience for elisas for RNF139
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for RNF139
     antibodies-online antibodies for RNF139 (33 products)
     antibodies-online kits for RNF139 (4 products)
     antibodies-online peptides for RNF139
     antibodies-online proteins for RNF139 (4 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RNF139 gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4