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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RNF139 Gene

protein-coding   GIFtS: 53
GCID: GC08P125487

Ring Finger Protein 139

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ring Finger Protein 1391 2 3     E3 Ubiquitin-Protein Ligase RNF1392
TRC82 3 5     Multiple Membrane Spanning Receptor TRC82
Translocation In Renal Carcinoma On Chromosome 8 Protein2 3     Patched Related Protein Translocated In Renal Cancer2
RCA12 5     EC 6.3.2.-3
HRCA12     

External Ids:    HGNC: 170231   Entrez Gene: 112362   Ensembl: ENSG000001708817   OMIM: 6030465   UniProtKB: Q8WU173   

Export aliases for RNF139 gene to outside databases

Previous GC identifers: GC08P125155 GC08P125443 GC08P125556 GC08P120812


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RNF139 Gene:
The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is
located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was
found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid
cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor
protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor
CDKN1B/P27KIP. (provided by RefSeq, Jul 2008)

GeneCards Summary for RNF139 Gene: 
RNF139 (ring finger protein 139) is a protein-coding gene. Diseases associated with RNF139 include hereditary renal cell carcinoma, and familial renal cell carcinoma, and among its related super-pathways are Regulation of Cholesterol Biosynthesis by SREBP (SREBF). GO annotations related to this gene include ubiquitin-protein ligase activity and ligase activity. An important paralog of this gene is SYVN1.

UniProtKB/Swiss-Prot: RN139_HUMAN, Q8WU17
Function: E3-ubiquitin ligase; acts as a negative regulator of the cell proliferation through mechanisms involving
G2/M arrest and cell death. Required for MHC class I ubiquitination in cells expressing the cytomegalovirus
protein US2 before dislocation from the endoplasmic reticulum (ER). Affects SREBP processing by hindering the
SREBP/SCAP complex translocation from the ER to the Golgi, thereby reducing SREBF2 target gene expression.
Required for INSIG1 ubiquitination. May be required for EIF3 complex ubiquitination. May function as a signaling
receptor

Gene Wiki entry for RNF139 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.2  NT_008046.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RNF139 gene promoter:
         Nkx3-1 v2   Nkx3-1   RORalpha1   Nkx3-1 v4   Pax-6   Nkx3-1 v3   Nkx3-1 v1   POU3F2   GATA-1   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNF139 promoter sequence
   Search SABiosciences Chromatin IP Primers for RNF139

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF139


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24   Ensembl cytogenetic band:  8q24.13   HGNC cytogenetic band: 8q24

RNF139 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF139 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P125487:  view genomic region     (about GC identifiers)

Start:
125,486,979 bp from pter      End:
125,500,859 bp from pter
Size:
13,881 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RN139_HUMAN, Q8WU17 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase RNF139  
Size: 664 amino acids; 75994 Da
Subunit: Interacts with VHL. Interacts with MHC class I and HM13. Component of SCAP/SREBP complex composed of
SREBF2, SCAP and RNF139; the complex hampers the interaction between SCAP and SEC24B, thereby reducing SREBF2
proteolytic processing. Interacts with SREBF2 (via C-terminus domain). Interacts with SCAP; the interaction
inhibits the interaction of SCAP with SEC24B and hampering the ER to Golgi transport of the SCAP/SREBP complex.
Interacts with SEC24B. Interacts with INSIG1 and INSIG2. Interacts with EIF3F and EIF3H; the interaction leads to
protein translation inhibitions in a ubiquitination-dependent manner
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein
Secondary accessions: B3KMD5 O75485 Q7LDL3

Explore the universe of human proteins at neXtProt for RNF139: NX_Q8WU17

Explore proteomics data for RNF139 at MOPED 

Post-translational modifications:

  • UniProtKB: Autoubiquitinated. Ubiquitination is induced by sterol and leads to ist degradation via the ubiquitin-proteasome
    pathway
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8WU17

  • RNF139 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RNF139 Protein Expression
    REFSEQ proteins: NP_009149.2  
    ENSEMBL proteins: 
     ENSP00000304051   ENSP00000429836  

    Human Recombinant Protein Products for RNF139: 
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    Cloud-Clone Corp. Proteins for RNF139 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA12032852
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral to membrane TAS12032852

    RNF139 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RNF: RING-type (C3HC4) zinc fingers

    3 InterPro protein domains:
     IPR001841 Znf_RING
     IPR025754 TRC8_N_dom
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q8WU17

    ProtoNet protein and cluster: Q8WU17

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: RN139_HUMAN, Q8WU17
    Domain: The RING-type zinc finger domain mediates ubiquitin ligase activity
    Similarity: Contains 1 RING-type zinc finger


    RNF139 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RN139_HUMAN, Q8WU17
    Function: E3-ubiquitin ligase; acts as a negative regulator of the cell proliferation through mechanisms involving
    G2/M arrest and cell death. Required for MHC class I ubiquitination in cells expressing the cytomegalovirus
    protein US2 before dislocation from the endoplasmic reticulum (ER). Affects SREBP processing by hindering the
    SREBP/SCAP complex translocation from the ER to the Golgi, thereby reducing SREBF2 target gene expression.
    Required for INSIG1 ubiquitination. May be required for EIF3 complex ubiquitination. May function as a signaling
    receptor
    Induction: Down-regulated by sterols (at protein level)

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IMP19720873
    GO:0004872receptor activity TAS9689122
    GO:0005515protein binding IPI12032852
    GO:0008270zinc ion binding IEA--
    GO:0016874ligase activity TAS10500182
         
    RNF139 for ontologies           About GeneDecksing


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    SwitchGear 3'UTR luciferase reporter plasmidRNF139 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RNF139 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Regulation of Cholesterol Biosynthesis by SREBP (SREBF)
    SREBP signalling0.37


    1 BioSystems Pathway for RNF139
        SREBP signalling


    UniProtKB/Swiss-Prot: RN139_HUMAN, Q8WU17
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNF139

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    5/20 Interacting proteins for RNF139 (Q8WU171, 3 ENSP000003040514) via UniProtKB, MINT, STRING, and/or I2D (see all 20)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    VHLP403371, 3, ENSP000002564744EBI-1551681,EBI-301246 I2D: score=3 STRING: ENSP00000256474
    COPS5Q929053, ENSP000003505124I2D: score=5 STRING: ENSP00000350512
    UBE2UQ5VVX93, ENSP000003601164I2D: score=2 STRING: ENSP00000360116
    EIF3FO003033, ENSP000003100404I2D: score=1 STRING: ENSP00000310040
    EIF3HO153723, ENSP000002766824I2D: score=1 STRING: ENSP00000276682
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008285negative regulation of cell proliferation IDA17016439
    GO:0016567protein ubiquitination IMP19720873
    GO:0017148negative regulation of translation IDA--
    GO:0031396regulation of protein ubiquitination IDA10500182
    GO:0060628regulation of ER to Golgi vesicle-mediated transport IDA19706601

    RNF139 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RNF139 (RN139)

    Search CenterWatch for drugs/clinical trials and news about RNF139 / RN139

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RNF139 gene: 
    NM_007218.3  

    Unigene Cluster for RNF139:

    Ring finger protein 139
    Hs.744151  [show with all ESTs]
    Unigene Representative Sequence: NM_007218
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000303545(uc003yrc.3) ENST00000517684
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidRNF139 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNF139

    Additional mRNA sequence: 

    AF064801.1 AK001602.1 AK025043.1 AK098519.1 BC021571.1 BC064636.1 

    8 DOTS entries:

    DT.453008  DT.99960535  DT.213432  DT.100772805  DT.100772808  DT.452925  DT.95367087  DT.92449754 

    24/130 AceView cDNA sequences (see all 130):

    AK001602 BG505335 BM693442 BC021571 AW009775 BI765465 AI362010 AA558801 
    AI339360 AF064801 BE219019 AL041427 BQ014422 AI668811 AU130820 AI480084 
    AL541293 BM919013 NM_007218 CR622053 BQ014830 AI218688 AK098519 BC064636 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RNF139 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACTTTGCCT
    RNF139 Expression
    About this image


    See RNF139 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RNF139

    SOURCE GeneReport for Unigene cluster: Hs.744151

    UniProtKB/Swiss-Prot: RN139_HUMAN, Q8WU17
    Tissue specificity: Highly expressed in testis, placenta and adrenal gland. Moderate expression in heart, brain,
    liver, skeletal muscle and pancreas, and low expression in lung and kidney

        SABiosciences Expression via Pathway-Focused PCR Arrays including RNF139: 
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              Ubiquitin Ligases in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RNF139 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnf1391 , 5 ring finger protein 1391, 5 91.57(n)1
    93.67(a)1
      15 (25.09 cM)5
    758411  NM_175226.41  NP_780435.11 
     588892295 
    chicken
    (Gallus gallus)
    Aves RNF1391 ring finger protein 139 75.25(n)
    80.03(a)
      420338  NM_001030955.1  NP_001026126.1 
    lizard
    (Anolis carolinensis)
    Reptilia RNF1396
    Uncharacterized protein
    75(a)
    1 ↔ 1
    4(6276458-6289256)
    African clawed frog
    (Xenopus laevis)
    Amphibia BX852394.12   -- 73.25(n)    BX852394.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rnf1391 ring finger protein 139 63.6(n)
    70.56(a)
      100144552  NM_001123048.1  NP_001116520.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Trc81 CG2304-PA 50.2(n)
    46.14(a)
      43476  NM_170414.1  NP_733293.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HRD16
    Ubiquitin-protein ligase required for endoplasmic ...
    10(a)
    1 → many
    XV(301380-303035)


    ENSEMBL Gene Tree for RNF139 (if available)
    TreeFam Gene Tree for RNF139 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RNF139 gene
    SYVN12  AMFR2  RNF1452  

    RNF139 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/303 SNPs in RNF139 are shown (see all 303)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3721902451,2
    C--125490846(+) TGTCT-/AAAAAA 1 -- int10--------
    rs1999115451,2
    C--125490964(+) TTTTT-/TGAGAC 1 -- int10--------
    rs113547781,2
    C--125492381(+) CTCTTA/-AAAAA 1 -- int1 trp31Minor allele frequency- -:0.00NA 2
    rs346616211,2
    C--125492646(+) AAAAA-/AAAAAA 1 -- int11Minor allele frequency- A:0.00NA 2
    rs784562041,2
    F--125495234(+) ATTTAT/AAAATA 1 -- int11Minor allele frequency- A:0.50NA 4
    rs3725962591,2
    C--125495264(+) TATATA/TTTAAA 1 -- int10--------
    rs719164401,2
    C--125495294(+) TATAT-/CTATTA 1 -- int10--------
    rs769047991,2
    F--125495332(+) TATATT/ATTTAA 1 -- int12Minor allele frequency- A:0.50NA 6
    rs795522911,2
    F--125495339(+) TTAAAT/AATATA 1 -- int12Minor allele frequency- A:0.33NA 6
    rs1415881481,2
    C--125759794(+) TTGCCA/CCTGCT 1 -- int10--------

    HapMap Linkage Disequilibrium report for RNF139 (125486979 - 125500859 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for RNF139:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv1307e199CNV Deletion23128226
    esv2660702CNV Deletion23128226
    esv1584427CNV Insertion17803354
    esv2523354CNV Insertion19546169
    nsv824727CNV Loss20364138
    dgv7874n71CNV Gain21882294


    Human Gene Mutation Database (HGMD): RNF139
    SABiosciences Cancer Mutation PCR Assays
    1 SABiosciences qBiomarker Copy Number PCR Array containing RNF139:
    Ovarian Cancer
    SeqTarget long-range PCR primers for resequencing RNF139
    DNA2.0 Custom Variant and Variant Library Synthesis for RNF139

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603046   
    OMIM disorders: 144700  
    UniProtKB/Swiss-Prot: RN139_HUMAN, Q8WU17
  • Renal cell carcinoma (RCC) [MIM:144700]: Renal cell carcinoma is a heterogeneous group of sporadic or
    hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear
    cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma,
    collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma. Clear
    cell renal cell carcinoma is the most common subtype. Note=The disease may be caused by mutations affecting the
    gene represented in this entry. A chromosomal aberration involving RNF139 has been found in a lymphoblastoid cell
    line established from a family with renal cell carcinoma and thyroid carcinoma. Translocation (3;8)(q14.2;q24.1)
    with FHIT. RNF139 is found to be fused to FHIT and disrupted within the sterol-sensing domain. In contrast, the
    FHIT coding region is maintained and expressed. Sporadic cases of renal carcinoma, where an acquired mutation in
    RNF139 results in the duplication of 12 nucleotides in the 5'-UTR, has also been identified

  • 13 diseases for RNF139:    About MalaCards
    hereditary renal cell carcinoma    familial renal cell carcinoma    collecting duct carcinoma    kidney cancer
    thyroid cancer    clear cell renal cell carcinoma    chromophobe renal cell carcinoma    renal cell carcinoma
    papillary renal cell carcinoma    dysgerminoma    thyroiditis    papillary carcinoma
    encephalitis

    1 disease from the University of Copenhagen DISEASES database for RNF139:
    Kidney cancer

    RNF139 for disorders           About GeneDecksing


    Export disorders for RNF139 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RNF139 gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with RNF139)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched-related gene, TRC8. (PubMed id 9689122)1, 2, 3, 9 Gemmill R.M.... Drabkin H.A. (1998)
    2. The TRC8 ubiquitin ligase is sterol regulated and int eracts with lipid and protein biosynthetic pathways. (PubMed id 20068067)1, 2, 9 Lee J.P....Gemmill R.M. (2010)
    3. The TRC8 E3 ligase ubiquitinates MHC class I molecule s before dislocation from the ER. (PubMed id 19720873)1, 2, 9 Stagg H.R....Lehner P.J. (2009)
    4. RING-dependent tumor suppression and G2/M arrest induced by the TRC8 hereditary kidney cancer gene. (PubMed id 17016439)1, 2, 9 Brauweiler A....Gemmill R.M. (2007)
    5. The sterol-sensing endoplasmic reticulum (ER) membran e protein TRC8 hampers ER to Golgi transport of sterol regulatory element-bindi ng protein-2 (SREBP-2)/SREBP cleavage-activated protein and reduces SREBP-2 cle avage. (PubMed id 19706601)1, 2 Irisawa M....Sato R. (2009)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. The TRC8 hereditary kidney cancer gene suppresses growth and functions with VHL in a common pathway. (PubMed id 12032852)1, 2 Gemmill R.M.... Drabkin H.A. (2002)
    10. RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination. (PubMed id 10500182)1, 2 Lorick K.L....Weissman A.M. (1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11236 HGNC: 17023 AceView: RNF139 Ensembl:ENSG00000170881 euGenes: HUgn11236
    ECgene: RNF139 H-InvDB: RNF139

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RNF139 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RNF139 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RNF139 gene:
    Search GeneIP for patents involving RNF139

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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