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Aliases for RNF138 Gene

Aliases for RNF138 Gene

  • Ring Finger Protein 138 2 3
  • Ring Finger Protein 138, E3 Ubiquitin Protein Ligase 2 3 5
  • Nemo-Like Kinase Associated Ring Finger Protein 2 3
  • Nemo-Like Kinase-Associated RING Finger Protein 3 4
  • NLK-Associated RING Finger Protein 3 4
  • HNARF 3 4
  • NARF 3 4
  • Testicular Tissue Protein Li 165 3
  • RING Finger Protein 138 4
  • EC 6.3.2.- 4
  • HSD-4 3
  • STRIN 3

External Ids for RNF138 Gene

Previous GeneCards Identifiers for RNF138 Gene

  • GC18P029559
  • GC18P027924
  • GC18P027923
  • GC18P027925
  • GC18P029671
  • GC18P026528

Summaries for RNF138 Gene

Entrez Gene Summary for RNF138 Gene

  • The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

GeneCards Summary for RNF138 Gene

RNF138 (Ring Finger Protein 138) is a Protein Coding gene. Among its related pathways are Antigen processing- Ubiquitination and Proteasome degradation and Immune System. GO annotations related to this gene include protein kinase binding and ligase activity. An important paralog of this gene is RNF166.

UniProtKB/Swiss-Prot for RNF138 Gene

  • E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination (PubMed:26502055, PubMed:26502057). Recruited to sites of double-strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination (PubMed:26502055, PubMed:26502057). Two different, non-exclusive, mechanisms have been proposed. According to a report, regulates the choice of double-strand break repair by favoring homologous recombination over non-homologous end joining (NHEJ): acts by mediating ubiquitination of XRCC5/Ku80, leading to remove the Ku complex from DNA breaks, thereby promoting homologous recombination (PubMed:26502055). According to another report, cooperates with UBE2Ds E2 ubiquitin ligases (UBE2D1, UBE2D2, UBE2D3 or UBE2D4) to promote homologous recombination by mediating ubiquitination of RBBP8/CtIP (PubMed:26502057). Together with NLK, involved in the ubiquitination and degradation of TCF/LEF (PubMed:16714285). Also exhibits auto-ubiquitination activity in combination with UBE2K (PubMed:16714285). May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway (PubMed:16714285).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF138 Gene

Genomics for RNF138 Gene

Regulatory Elements for RNF138 Gene

Enhancers for RNF138 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RNF138 on UCSC Golden Path with GeneCards custom track

Promoters for RNF138 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RNF138 on UCSC Golden Path with GeneCards custom track

Genomic Location for RNF138 Gene

Chromosome:
18
Start:
32,091,855 bp from pter
End:
32,131,561 bp from pter
Size:
39,707 bases
Orientation:
Plus strand

Genomic View for RNF138 Gene

Genes around RNF138 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF138 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF138 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF138 Gene

Proteins for RNF138 Gene

  • Protein details for RNF138 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WVD3-RN138_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase RNF138
    Protein Accession:
    Q8WVD3
    Secondary Accessions:
    • B2RE17
    • Q9H8K2
    • Q9UF87
    • Q9UKI6

    Protein attributes for RNF138 Gene

    Size:
    245 amino acids
    Molecular mass:
    28193 Da
    Quaternary structure:
    • Interacts with NLK (PubMed:16714285). Interacts with XRCC5/Ku80 (PubMed:26502055). Interacts with RBBP8/CtIP (PubMed:26502057).

    Alternative splice isoforms for RNF138 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNF138 Gene

Proteomics data for RNF138 Gene at MOPED

Post-translational modifications for RNF138 Gene

Other Protein References for RNF138 Gene

No data available for DME Specific Peptides for RNF138 Gene

Domains & Families for RNF138 Gene

Gene Families for RNF138 Gene

Protein Domains for RNF138 Gene

Suggested Antigen Peptide Sequences for RNF138 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WVD3

UniProtKB/Swiss-Prot:

RN138_HUMAN :
  • The zinc finger domains (C2H2-type and C2HC-type zinc fingers) bind DNA and mediate recruitment to double-strand break sites. They show strong preference for DNA with 5- or 3-single-stranded overhangs, while they do not bind blunt-ended double-stranded DNA or poly(ADP-ribose) (PAR) polymers.
  • Contains 2 C2H2-type zinc fingers.
Domain:
  • The zinc finger domains (C2H2-type and C2HC-type zinc fingers) bind DNA and mediate recruitment to double-strand break sites. They show strong preference for DNA with 5- or 3-single-stranded overhangs, while they do not bind blunt-ended double-stranded DNA or poly(ADP-ribose) (PAR) polymers.
  • Contains 1 UIM (ubiquitin-interacting motif) domain.
Similarity:
  • Contains 2 C2H2-type zinc fingers.
  • Contains 1 C2HC-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF138: view

Function for RNF138 Gene

Molecular function for RNF138 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination (PubMed:26502055, PubMed:26502057). Recruited to sites of double-strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination (PubMed:26502055, PubMed:26502057). Two different, non-exclusive, mechanisms have been proposed. According to a report, regulates the choice of double-strand break repair by favoring homologous recombination over non-homologous end joining (NHEJ): acts by mediating ubiquitination of XRCC5/Ku80, leading to remove the Ku complex from DNA breaks, thereby promoting homologous recombination (PubMed:26502055). According to another report, cooperates with UBE2Ds E2 ubiquitin ligases (UBE2D1, UBE2D2, UBE2D3 or UBE2D4) to promote homologous recombination by mediating ubiquitination of RBBP8/CtIP (PubMed:26502057). Together with NLK, involved in the ubiquitination and degradation of TCF/LEF (PubMed:16714285). Also exhibits auto-ubiquitination activity in combination with UBE2K (PubMed:16714285). May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway (PubMed:16714285).

Enzyme Numbers (IUBMB) for RNF138 Gene

Gene Ontology (GO) - Molecular Function for RNF138 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003697 single-stranded DNA binding IDA 26502055
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with RNF138: view
genes like me logo Genes that share phenotypes with RNF138: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNF138 Gene

Localization for RNF138 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF138 Gene

Chromosome. Note=Recruited at DNA damage sites (PubMed:26502055). Localizes to sites of double-strand break: localization to double-strand break sites is mediated by the zinc fingers (PubMed:26502055, PubMed:26502057). {ECO:0000269 PubMed:26502055, ECO:0000269 PubMed:26502057}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNF138 Gene COMPARTMENTS Subcellular localization image for RNF138 gene
Compartment Confidence
nucleus 5
extracellular 2
mitochondrion 2
cytosol 1

No data available for Gene Ontology (GO) - Cellular Components for RNF138 Gene

Pathways & Interactions for RNF138 Gene

genes like me logo Genes that share pathways with RNF138: view

UniProtKB/Swiss-Prot Q8WVD3-RN138_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for RNF138 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016055 Wnt signaling pathway IEA --
genes like me logo Genes that share ontologies with RNF138: view

No data available for SIGNOR curated interactions for RNF138 Gene

Drugs & Compounds for RNF138 Gene

(3) Drugs for RNF138 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Diphosphate Experimental Pharma 0

(1) Additional Compounds for RNF138 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
genes like me logo Genes that share compounds with RNF138: view

Transcripts for RNF138 Gene

Unigene Clusters for RNF138 Gene

Ring finger protein 138, E3 ubiquitin protein ligase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNF138 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8 ^ 9
SP1: - -
SP2:
SP3: - - -
SP4: - - -
SP5: -
SP6: -

Relevant External Links for RNF138 Gene

GeneLoc Exon Structure for
RNF138
ECgene alternative splicing isoforms for
RNF138

Expression for RNF138 Gene

mRNA expression in normal human tissues for RNF138 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNF138 Gene

This gene is overexpressed in Testis (x5.8).

Protein differential expression in normal tissues from HIPED for RNF138 Gene

This gene is overexpressed in Lung (37.9), Fetal ovary (14.0), and Testis (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RNF138 Gene



SOURCE GeneReport for Unigene cluster for RNF138 Gene Hs.302408

genes like me logo Genes that share expression patterns with RNF138: view

Protein tissue co-expression partners for RNF138 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for RNF138 Gene

Orthologs for RNF138 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNF138 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RNF138 35
  • 95.24 (n)
  • 97.14 (a)
RNF138 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNF138 35
  • 96.14 (n)
  • 99.52 (a)
RNF138 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnf138 35
  • 93.33 (n)
  • 93.88 (a)
Rnf138 16
Rnf138 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RNF138 35
  • 99.86 (n)
  • 100 (a)
RNF138 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnf138 35
  • 90.59 (n)
  • 90.91 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 88 (a)
OneToMany
-- 36
  • 86 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia RNF138 36
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves RNF138 35
  • 75.96 (n)
  • 70.49 (a)
RNF138 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RNF138 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf138 35
  • 60.94 (n)
  • 54.3 (a)
Species with no ortholog for RNF138:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RNF138 Gene

ENSEMBL:
Gene Tree for RNF138 (if available)
TreeFam:
Gene Tree for RNF138 (if available)

Paralogs for RNF138 Gene

Paralogs for RNF138 Gene

(6) SIMAP similar genes for RNF138 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for RNF138 Gene

genes like me logo Genes that share paralogs with RNF138: view

Variants for RNF138 Gene

Sequence variations from dbSNP and Humsavar for RNF138 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs7229690 - 32,111,885(+) GAGGA(A/G)GTTTT intron-variant, nc-transcript-variant, reference, missense
rs11333 -- 32,130,552(-) GTTAT(A/T)TTAAA nc-transcript-variant, utr-variant-3-prime
rs4799327 -- 32,095,029(+) TGTAC(A/G)TAGAC intron-variant
rs4799328 -- 32,122,387(+) GAAAA(A/T)TGAAT intron-variant
rs4799630 -- 32,094,606(+) CTGAC(A/G)TGAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNF138 Gene

Variant ID Type Subtype PubMed ID
dgv1021e1 CNV Complex 17122850
dgv3404n71 CNV Gain 21882294
esv2716941 CNV Deletion 23290073
nsv2248 CNV Insertion 18451855
esv2716942 CNV Deletion 23290073
esv2141547 CNV Deletion 18987734
esv2716943 CNV Deletion 23290073
esv2716944 CNV Deletion 23290073

Variation tolerance for RNF138 Gene

Residual Variation Intolerance Score: 58.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.54; 44.32% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RNF138 Gene

Disorders for RNF138 Gene

Relevant External Links for RNF138

Genetic Association Database (GAD)
RNF138
Human Genome Epidemiology (HuGE) Navigator
RNF138
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RNF138

No disorders were found for RNF138 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF138 Gene

Publications for RNF138 Gene

  1. NARF, an nemo-like kinase (NLK)-associated ring finger protein regulates the ubiquitylation and degradation of T cell factor/lymphoid enhancer factor (TCF/LEF). (PMID: 16714285) Yamada M. … Shibuya H. (J. Biol. Chem. 2006) 2 3 4 67
  2. A novel gene RNF138 expressed in human gliomas and its function in the glioma cell line U251. (PMID: 22155992) Zhou Y.X. … Du Z.W. (Anal Cell Pathol (Amst) 2012) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. The RNF138 E3 ligase displaces Ku to promote DNA end resection and regulate DNA repair pathway choice. (PMID: 26502055) Ismail I.H. … Hendzel M.J. (Nat. Cell Biol. 2015) 3
  5. Systematic E2 screening reveals a UBE2D-RNF138-CtIP axis promoting DNA repair. (PMID: 26502057) Schmidt C.K. … Jackson S.P. (Nat. Cell Biol. 2015) 3

Products for RNF138 Gene

Sources for RNF138 Gene

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