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Aliases for RNF138 Gene

Aliases for RNF138 Gene

  • Ring Finger Protein 138, E3 Ubiquitin Protein Ligase 2 3
  • Nemo-Like Kinase Associated Ring Finger Protein 2 3
  • Nemo-Like Kinase-Associated RING Finger Protein 3 4
  • NLK-Associated RING Finger Protein 3 4
  • HNARF 3 4
  • NARF 3 4
  • E3 Ubiquitin-Protein Ligase RNF138 3
  • Ring Finger Protein 138 2
  • RING Finger Protein 138 4
  • EC 6.3.2.- 4
  • HSD-4 3
  • STRIN 3

External Ids for RNF138 Gene

Previous GeneCards Identifiers for RNF138 Gene

  • GC18P029559
  • GC18P027924
  • GC18P027923
  • GC18P027925
  • GC18P029671
  • GC18P026528

Summaries for RNF138 Gene

Entrez Gene Summary for RNF138 Gene

  • The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

GeneCards Summary for RNF138 Gene

RNF138 (Ring Finger Protein 138, E3 Ubiquitin Protein Ligase) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include protein kinase binding and ligase activity. An important paralog of this gene is RNF166.

UniProtKB/Swiss-Prot for RNF138 Gene

  • E3 ubiquitin-protein ligase. Together with NLK, involved in the ubiquitination and degradation of TCF/LEF. Also exhibits auto-ubiquitination activity in combination with UBE2K. May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF138 Gene

Genomics for RNF138 Gene

Regulatory Elements for RNF138 Gene

Genomic Location for RNF138 Gene

Start:
32,091,855 bp from pter
End:
32,131,561 bp from pter
Size:
39,707 bases
Orientation:
Plus strand

Genomic View for RNF138 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNF138 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF138 Gene

Proteins for RNF138 Gene

  • Protein details for RNF138 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WVD3-RN138_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase RNF138
    Protein Accession:
    Q8WVD3
    Secondary Accessions:
    • B2RE17
    • Q9H8K2
    • Q9UF87
    • Q9UKI6

    Protein attributes for RNF138 Gene

    Size:
    245 amino acids
    Molecular mass:
    28193 Da
    Quaternary structure:
    • Interacts with NLK.

    Alternative splice isoforms for RNF138 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNF138 Gene

Proteomics data for RNF138 Gene at MOPED

Post-translational modifications for RNF138 Gene

Other Protein References for RNF138 Gene

No data available for DME Specific Peptides for RNF138 Gene

Domains for RNF138 Gene

Gene Families for RNF138 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for RNF138 Gene

Suggested Antigen Peptide Sequences for RNF138 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WVD3

UniProtKB/Swiss-Prot:

RN138_HUMAN :
  • Q8WVD3
Domain:
  • The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF138: view

Function for RNF138 Gene

Molecular function for RNF138 Gene

UniProtKB/Swiss-Prot Function: E3 ubiquitin-protein ligase. Together with NLK, involved in the ubiquitination and degradation of TCF/LEF. Also exhibits auto-ubiquitination activity in combination with UBE2K. May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway.

Enzyme Numbers (IUBMB) for RNF138 Gene

Gene Ontology (GO) - Molecular Function for RNF138 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19549727
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0019901 protein kinase binding IPI 16714285
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with RNF138: view

Phenotypes for RNF138 Gene

genes like me logo Genes that share phenotypes with RNF138: view

Animal Model Products

CRISPR Products

miRNA for RNF138 Gene

miRTarBase miRNAs that target RNF138

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNF138

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for RNF138 Gene

Localization for RNF138 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNF138 Gene COMPARTMENTS Subcellular localization image for RNF138 gene
Compartment Confidence
nucleus 3
extracellular 2
mitochondrion 2
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RNF138 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
genes like me logo Genes that share ontologies with RNF138: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RNF138 Gene

Pathways for RNF138 Gene

genes like me logo Genes that share pathways with RNF138: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Toll-Like Receptor Signaling Pathway in human,mouse,rat
    • Ubiquitin Ligases in human,mouse,rat

UniProtKB/Swiss-Prot Q8WVD3-RN138_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for RNF138 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016055 Wnt signaling pathway IEA --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with RNF138: view

Compounds for RNF138 Gene

(4) HMDB Compounds for RNF138 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
61-19-8
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2
Pyrophosphate
  • (4-)Diphosphoric acid ion
14000-31-8
genes like me logo Genes that share compounds with RNF138: view

Transcripts for RNF138 Gene

Unigene Clusters for RNF138 Gene

Ring finger protein 138, E3 ubiquitin protein ligase:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNF138

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF138 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8 ^ 9
SP1: - -
SP2:
SP3: - - -
SP4: - - -
SP5: -
SP6: -

Relevant External Links for RNF138 Gene

GeneLoc Exon Structure for
RNF138
ECgene alternative splicing isoforms for
RNF138

Expression for RNF138 Gene

mRNA expression in normal human tissues for RNF138 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNF138 Gene

This gene is overexpressed in Testis (5.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RNF138 Gene

SOURCE GeneReport for Unigene cluster for RNF138 Gene Hs.302408

genes like me logo Genes that share expressions with RNF138: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for RNF138 Gene

Orthologs for RNF138 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNF138 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNF138 35
  • 99.86 (n)
  • 100 (a)
RNF138 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RNF138 35
  • 95.24 (n)
  • 97.14 (a)
RNF138 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNF138 35
  • 96.14 (n)
  • 99.52 (a)
RNF138 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnf138 35
  • 93.33 (n)
  • 93.88 (a)
Rnf138 16
Rnf138 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 88 (a)
OneToMany
-- 36
  • 86 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia RNF138 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnf138 35
  • 90.59 (n)
  • 90.91 (a)
chicken
(Gallus gallus)
Aves RNF138 35
  • 75.96 (n)
  • 70.49 (a)
RNF138 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RNF138 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf138 35
  • 60.94 (n)
  • 54.3 (a)
Species with no ortholog for RNF138:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RNF138 Gene

ENSEMBL:
Gene Tree for RNF138 (if available)
TreeFam:
Gene Tree for RNF138 (if available)

Paralogs for RNF138 Gene

Paralogs for RNF138 Gene

Selected SIMAP similar genes for RNF138 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for RNF138 Gene

genes like me logo Genes that share paralogs with RNF138: view

Variants for RNF138 Gene

Sequence variations from dbSNP and Humsavar for RNF138 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs11333 -- 32,130,552(-) GTTAT(A/T)TTAAA utr-variant-3-prime, nc-transcript-variant
rs593234 -- 32,099,959(-) TGCAA(C/T)TATTC intron-variant
rs620001 -- 32,120,943(+) ccagc(C/G/T)tggcc intron-variant
rs684359 -- 32,129,018(+) TGTGT(A/G)TCAAG intron-variant
rs684693 -- 32,101,283(-) caaga(C/T)tgcgt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNF138 Gene

Variant ID Type Subtype PubMed ID
dgv1021e1 CNV Complex 17122850
dgv3404n71 CNV Gain 21882294
esv2716941 CNV Deletion 23290073
nsv2248 CNV Insertion 18451855
esv2716942 CNV Deletion 23290073
esv2141547 CNV Deletion 18987734
esv2716943 CNV Deletion 23290073
esv2716944 CNV Deletion 23290073

Relevant External Links for RNF138 Gene

HapMap Linkage Disequilibrium report
RNF138

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF138 Gene

Disorders for RNF138 Gene

Relevant External Links for RNF138

Genetic Association Database (GAD)
RNF138
Human Genome Epidemiology (HuGE) Navigator
RNF138
genes like me logo Genes that share disorders with RNF138: view

No data available for UniProtKB/Swiss-Prot for RNF138 Gene

Publications for RNF138 Gene

  1. NARF, an nemo-like kinase (NLK)-associated ring finger protein regulates the ubiquitylation and degradation of T cell factor/lymphoid enhancer factor (TCF/LEF). (PMID: 16714285) Yamada M. … Shibuya H. (J. Biol. Chem. 2006) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. A novel gene RNF138 expressed in human gliomas and its function in the glioma cell line U251. (PMID: 22155992) Zhou Y.X. … Du Z.W. (Anal Cell Pathol (Amst) 2012) 2 3

Products for RNF138 Gene

Sources for RNF138 Gene

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