Aliases for RNF138 Gene
External Ids for RNF138 Gene
Previous GeneCards Identifiers for RNF138 Gene
The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
GeneCards Summary for RNF138 Gene
RNF138 (Ring Finger Protein 138, E3 Ubiquitin Protein Ligase) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include protein kinase binding and ligase activity. An important paralog of this gene is RNF166.
UniProtKB/Swiss-Prot for RNF138 Gene
E3 ubiquitin-protein ligase. Together with NLK, involved in the ubiquitination and degradation of TCF/LEF. Also exhibits auto-ubiquitination activity in combination with UBE2K. May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway.