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RNF138 Gene

protein-coding   GIFtS: 57
GCID: GC18P029671

Ring Finger Protein 138, E3 Ubiquitin Protein Ligase

(Previous name: ring finger protein 138)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ring Finger Protein 138, E3 Ubiquitin Protein Ligase1 2     NLK-Associated RING Finger Protein2 3
RING Finger Protein 1381 3     HSD-42
Nemo-Like Kinase Associated Ring Finger Protein1 2     STRIN2
NARF2 3     E3 Ubiquitin-Protein Ligase RNF1382
hNARF2 3     EC 6.3.2.-3
Nemo-Like Kinase-Associated RING Finger Protein2 3     

External Ids:    HGNC: 177651   Entrez Gene: 514442   Ensembl: ENSG000001347587   UniProtKB: Q8WVD33   

Export aliases for RNF138 gene to outside databases

Previous GC identifers: GC18P029559 GC18P027924 GC18P027923 GC18P027925 GC18P026528


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RNF138 Gene:
The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct
proteins and known to be involved in protein-DNA and protein-protein interactions. Alternatively spliced
transcript variants encoding distinct isoforms have been observed. (provided by RefSeq, Jul 2008)

GeneCards Summary for RNF138 Gene:
RNF138 (ring finger protein 138, E3 ubiquitin protein ligase) is a protein-coding gene. Diseases associated with RNF138 include crohn's disease, and ataxia. GO annotations related to this gene include protein kinase binding and ligase activity. An important paralog of this gene is RNF125.

UniProtKB/Swiss-Prot: RN138_HUMAN, Q8WVD3
Function: E3 ubiquitin-protein ligase. Together with NLK, involved in the ubiquitination and degradation of
TCF/LEF. Also exhibits auto-ubiquitination activity in combination with UBE2K. May act as a negative regulator in
the Wnt/beta-catenin-mediated signaling pathway




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000018.10  NT_010966.15  NC_018929.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RNF138 gene promoter:
         Max   STAT5B   HFH-1   CUTL1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNF138 promoter sequence
   Search Chromatin IP Primers for RNF138

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNF138


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q12.1   Ensembl cytogenetic band:  18q12.1   HGNC cytogenetic band: 18q12.1

RNF138 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF138 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P029671:  view genomic region     (about GC identifiers)

Start:
29,671,818 bp from pter      End:
29,711,524 bp from pter
Size:
39,707 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RN138_HUMAN, Q8WVD3 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase RNF138  
Size: 245 amino acids; 28193 Da
Subunit: Interacts with NLK
Secondary accessions: B2RE17 Q9H8K2 Q9UF87 Q9UKI6
Alternative splicing: 2 isoforms:  Q8WVD3-1   Q8WVD3-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RNF138: NX_Q8WVD3

Explore proteomics data for RNF138 at MOPED

Post-translational modifications: 

  • Auto-ubiquitinated1
  • Ubiquitination2 at Lys26, Lys41, Lys91, Lys94, Lys158
  • Modification sites at PhosphoSitePlus

  • See RNF138 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001178253.2  NP_057355.2  NP_937761.1  

    ENSEMBL proteins: 
     ENSP00000261593   ENSP00000462165   ENSP00000462498   ENSP00000257190   ENSP00000463153  
     ENSP00000463659  
    Reactome Protein details: Q8WVD3

    RNF138 Human Recombinant Protein Products:

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    Novus Biologicals RNF138 Lysates
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    Cloud-Clone Corp. Proteins for RNF138

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers

    5 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001841 Znf_RING
     IPR008598 Di19_Zn_binding
     IPR018957 Znf_C3HC4_RING-type
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q8WVD3

    ProtoNet protein and cluster: Q8WVD3

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: RN138_HUMAN, Q8WVD3
    Domain: The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme (By similarity)
    Similarity: Contains 1 RING-type zinc finger


    RNF138 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RN138_HUMAN, Q8WVD3
    Function: E3 ubiquitin-protein ligase. Together with NLK, involved in the ubiquitination and degradation of
    TCF/LEF. Also exhibits auto-ubiquitination activity in combination with UBE2K. May act as a negative regulator in
    the Wnt/beta-catenin-mediated signaling pathway

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0016874ligase activity IEA--
    GO:0019901protein kinase binding IPI16714285
    GO:0046872metal ion binding ----
         
    RNF138 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for RNF138:
     Increased cell death HMECs cel  Proliferating cells  Synthetic lethal with c-Myc af 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RNF138
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    miRNA
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    miRTarBase miRNAs that target RNF138:
    hsa-mir-1 (MIRT002787), hsa-mir-421 (MIRT016112)

    Block miRNA regulation of human, mouse, rat RNF138 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RNF138 (see all 65):
    hsa-miR-142-5p hsa-miR-582-3p hsa-miR-3678-3p hsa-miR-15a hsa-miR-503 hsa-miR-29a hsa-miR-3171 hsa-miR-183*
    SwitchGear 3'UTR luciferase reporter plasmidRNF138 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RNF138

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF138


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    extracellular2
    mitochondrion2
    cytosol1
    peroxisome1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RNF138 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for RNF138
        Antigen processing: Ubiquitination & Proteasome degradation


    UniProtKB/Swiss-Prot: RN138_HUMAN, Q8WVD3
    Pathway: Protein modification; protein ubiquitination


    RNF138 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including RNF138: 

              Toll-Like Receptor Signaling Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for RNF138

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for RNF138 (Q8WVD32, 3 ENSP000002615934) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PCBP4P577232, 3, ENSP000003784614MINT-2873385 I2D: score=2 STRING: ENSP00000378461
    C6orf165Q8IYR02, 3MINT-67412 I2D: score=4 
    QKIQ96PU82, 3, ENSP000003549514MINT-2873404 I2D: score=3 STRING: ENSP00000354951
    TAF9Q165942, 3, ENSP000002178934MINT-2873423 I2D: score=3 STRING: ENSP00000217893
    UBE2D2P628373, ENSP000003817174I2D: score=2 STRING: ENSP00000381717
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016055Wnt signaling pathway IEA--
    GO:0016567protein ubiquitination IEA--

    RNF138 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RNF138 (RN138)

    4 HMDB Compounds for RNF138    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RNF138 gene (3 alternative transcripts): 
    NM_001191324.1  NM_016271.4  NM_198128.2  

    Unigene Cluster for RNF138:

    Ring finger protein 138, E3 ubiquitin protein ligase
    Hs.302408  [show with all ESTs]
    Unigene Representative Sequence: NM_016271
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261593(uc002kxg.3 uc021uip.1 uc002kxh.3) ENST00000585103
    ENST00000578914 ENST00000580519 ENST00000578107 ENST00000583733 ENST00000257190
    ENST00000580499 ENST00000577999
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate RNF138 (see all 65):
    hsa-miR-142-5p hsa-miR-582-3p hsa-miR-3678-3p hsa-miR-15a hsa-miR-503 hsa-miR-29a hsa-miR-3171 hsa-miR-183*
    SwitchGear 3'UTR luciferase reporter plasmidRNF138 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat RNF138
      QuantiFast Probe-based Assays in human, mouse, rat RNF138

    Additional mRNA sequence: 

    AF162680.3 AK023579.1 AK315761.1 AL133557.1 BC018107.1 BT006878.1 CR457150.1 

    11 DOTS entries:

    DT.414102  DT.100786118  DT.100786121  DT.97795008  DT.92436213  DT.121090424  DT.121090429  DT.121090471 
    DT.40196238  DT.121090420  DT.121090418 

    Selected AceView cDNA sequences (see all 163):

    NM_198128 BM463218 BX451775 NM_016271 AA576876 BC018107 BE892495 CR594800 
    BM727972 AA361819 AU253463 CR614694 CK904362 BU153978 AA768118 BM973119 
    AA446302 AA461508 BE350955 BX106187 BM987886 BE887697 N49156 CB856619 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RNF138 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8 ^ 9
    SP1:                          -           -                                                         
    SP2:                                                                                                
    SP3:                          -           -     -                                                   
    SP4:                          -     -     -                                                         
    SP5:                          -                                                                     


    ECgene alternative splicing isoforms for RNF138

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RNF138 expression in normal human tissues (normalized intensities)      RNF138 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCATTTGAT
    RNF138 Expression
    About this image


    RNF138 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    RNF138 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RNF138 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.302408
        Pathway & Disease-focused RT2 Profiler PCR Arrays including RNF138: 
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for RNF138
    OriGene qSTAR qPCR primer pairs in human, mouse for RNF138
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RNF138
    QuantiTect SYBR Green Assays in human, mouse, rat RNF138
    QuantiFast Probe-based Assays in human, mouse, rat RNF138
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF138

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for RNF138 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnf1381 , 5 ring finger protein 1381, 5 93.33(n)1
    93.88(a)1
      18 (11.73 cM)5
    565151  NM_207623.11  NP_997506.11 
     210013415 
    chicken
    (Gallus gallus)
    Aves RNF1381 ring finger protein 138, E3 ubiquitin protein ligase 75.96(n)
    70.49(a)
      421096  XM_004939822.1  XP_004939879.1 
    lizard
    (Anolis carolinensis)
    Reptilia RNF1386
    ring finger protein 138, E3 ubiquitin protein liga...
    58(a)
    1 ↔ 1
    GL343207.1(3421436-3436052)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BG512761.12   -- 70.32(n)    BG512761.1 


    ENSEMBL Gene Tree for RNF138 (if available)
    TreeFam Gene Tree for RNF138 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RNF138 gene
    RNF1252  RNF1662  RNF1142  
    6 SIMAP similar genes for RNF138 using alignment to 5 protein entries:     RN138_HUMAN (see all proteins):
    RNF151    PCGF3    SH3RF1    TRIM60    TRIM5    TRIM59

    RNF138 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for RNF138
    PGOHUM00000235223 PGOHUM00000263179


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RNF138 (see all 898)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1393606001,2
    --26526443(+) AAGATA/TGTGTC 1 -- us2k10--------
    rs1455526811,2
    --26526491(+) CCAAGA/GGTATC 1 -- us2k10--------
    rs47996291,2
    C,F,A,H--26526635(+) CTGCCG/ATTGCA 1 -- us2k125Minor allele frequency- A:0.26NS EA NA WA 2938
    rs1907532441,2
    C--29662986(+) GGATCA/GCTGGA 1 -- us2k10--------
    rs1426221581,2
    C--29663000(+) CAGGAG/TTTCGA 1 -- us2k10--------
    rs1442303501,2
    --29663175(+) CACCCC/TAGCCT 1 -- us2k10--------
    rs1820416781,2
    --29663214(+) AGAAAA/GAAGAA 1 -- us2k10--------
    rs1127412671,2
    C,F--29663265(+) CTCAAG/AGAACC 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1488143501,2
    C--29663285(+) GTGAAC/TGTGAA 1 -- us2k10--------
    rs1435015671,2
    --29663319(+) GCTGCC/TCCTCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RNF138 (29671818 - 29711524 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for RNF138:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2141547CNV Deletion18987734
    esv2716943CNV Deletion23290073
    esv2716942CNV Deletion23290073
    esv2716944CNV Deletion23290073
    esv2716941CNV Deletion23290073
    nsv2248CNV Insertion18451855
    dgv3404n71CNV Gain21882294
    dgv1021e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases for RNF138:    About MalaCards
    crohn's disease    ataxia


    RNF138 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RNF138
    Human Genome Epidemiology (HuGE) Navigator: RNF138 (1 document)

    Export disorders for RNF138 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RNF138 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with RNF138)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. NARF, an nemo-like kinase (NLK)-associated ring finger protein regulates the ubiquitylation and degradation of T cell factor/lymphoid enhancer factor (TCF/LEF). (PubMed id 16714285)1, 2, 3 Yamada M.... Shibuya H. (J. Biol. Chem. 2006)
    2. A novel gene RNF138 expressed in human gliomas and its function in the glioma cell line U251. (PubMed id 22155992)1, 3 Zhou Y.X....Du Z.W. (Anal Cell Pathol (Amst) 2012)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)1 Woodsmith J....Sanderson C.M. (amp 2012)
    7. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    8. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (Cell 2010)
    9. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (Anal. Chem. 2009)
    10. Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. (PubMed id 19549727)1 Markson G....Sanderson C.M. (Genome Res. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51444 HGNC: 17765 AceView: RNF138 Ensembl:ENSG00000134758 euGenes: HUgn51444
    ECgene: RNF138 H-InvDB: RNF138

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RNF138 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for RNF138 gene:
    Search GeneIP for patents involving RNF138

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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