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RNF135 Gene

protein-coding   GIFtS: 57
GCID: GC17P029297

Ring Finger Protein 135

  See RNF135-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ring Finger Protein 1351 2 3     MMFD2 5
REUL2 3     riplet1
Riplet2 3     E3 Ubiquitin-Protein Ligase RNF1352
RIG-I E3 Ubiquitin Ligase2 3     EC 6.3.2.-3

External Ids:    HGNC: 211581   Entrez Gene: 842822   Ensembl: ENSG000001814817   OMIM: 6113585   UniProtKB: Q8IUD63   

Export aliases for RNF135 gene to outside databases

Previous GC identifers: GC17P029147 GC17P029443 GC17P026322 GC17P025508


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RNF135 Gene:
The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally
distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is located
in a chromosomal region known to be frequently deleted in patients with neurofibromatosis. Alternatively spliced
transcript variants encoding distinct isoforms have been reported. (provided by RefSeq, Jul 2008)

GeneCards Summary for RNF135 Gene:
RNF135 (ring finger protein 135) is a protein-coding gene. Diseases associated with RNF135 include macrocephaly, macrosomia, facial dysmorphism syndrome, and iris hypoplasia and glaucoma. GO annotations related to this gene include ubiquitin-protein ligase activity and ribonucleoprotein complex binding.

UniProtKB/Swiss-Prot: RN135_HUMAN, Q8IUD6
Function: Acts as an E2-dependent E3 ubiquitin-protein ligase, involved in innate immune defense against viruses.
Ubiquitinates DDX58 and is required for full activation of the DDX58 signaling resulting in interferon beta
production

Gene Wiki entry for RNF135 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RNF135 gene promoter:
         NF-1   NF-1/L   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNF135 promoter sequence
   Search Chromatin IP Primers for RNF135

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNF135


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2   Ensembl cytogenetic band:  17q11.2   HGNC cytogenetic band: 17q11.2

RNF135 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF135 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P029297:  view genomic region     (about GC identifiers)

Start:
29,295,803 bp from pter      End:
29,326,929 bp from pter
Size:
31,127 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RN135_HUMAN, Q8IUD6 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase RNF135  
Size: 432 amino acids; 47888 Da
Subunit: Interacts with DDX58. Interacts with PCBP2
Secondary accessions: A0AVM5 B2R7G9 B6ZLM5 F5GX60 Q9BSE9
Alternative splicing: 3 isoforms:  Q8IUD6-1   Q8IUD6-2   Q8IUD6-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RNF135: NX_Q8IUD6

Explore proteomics data for RNF135 at MOPED


See RNF135 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (3 alternative transcripts): 
NP_001171921.1  NP_115698.3  NP_922921.1  

ENSEMBL proteins: 
 ENSP00000328340   ENSP00000411965   ENSP00000323693   ENSP00000440470   ENSP00000464549  
 ENSP00000467799  
Reactome Protein details: Q8IUD6

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Novus Biologicals RNF135 Lysates
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Cloud-Clone Corp. Proteins for RNF135

 
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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
RNF: RING-type (C3HC4) zinc fingers

Selected InterPro protein domains (see all 8):
 IPR006574 PRY
 IPR017907 Znf_RING_CS
 IPR001841 Znf_RING
 IPR001870 B30.2/SPRY
 IPR003877 SPRY_rcpt

Graphical View of Domain Structure for InterPro Entry Q8IUD6

ProtoNet protein and cluster: Q8IUD6

3 Blocks protein domains:
IPB001841 Zn-finger
IPB003879 Butyrophylin C-terminal DUF signature
IPB006574 SPRY-associated domain


UniProtKB/Swiss-Prot: RN135_HUMAN, Q8IUD6
Similarity: Contains 1 B30.2/SPRY domain
Similarity: Contains 1 RING-type zinc finger


Find genes that share domains with RNF135           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: RN135_HUMAN, Q8IUD6
Function: Acts as an E2-dependent E3 ubiquitin-protein ligase, involved in innate immune defense against viruses.
Ubiquitinates DDX58 and is required for full activation of the DDX58 signaling resulting in interferon beta
production

     Enzyme Number (IUBMB): EC 6.3.2.-1

     Gene Ontology (GO): 5 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004842ubiquitin-protein ligase activity IDA19484123
GO:0005515protein binding IPI19017631
GO:0008270zinc ion binding IEA--
GO:0043021ribonucleoprotein complex binding IPI19881509
GO:0046872metal ion binding ----
     
Find genes that share ontologies with RNF135           About GenesLikeMe


Phenotypes:
     1 GenomeRNAi human phenotype for RNF135:
 Decreased viability with pacli 

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RNF135
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RNF135

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RNF135
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RNF135

miRNA
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2 qRT-PCR Assays for microRNAs that regulate RNF135:
hsa-miR-124 hsa-miR-506
SwitchGear 3'UTR luciferase reporter plasmidRNF135 3' UTR sequence
Inhib. RNA
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OriGene RNAi products in human, mouse, rat for RNF135
Predesigned siRNA for gene silencing in human, mouse, rat RNF135

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GenScript: all cDNA clones in your preferred vector (see all 3): RNF135 (NM_197939)
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF135


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
RN135_HUMAN, Q8IUD6: Cytoplasm
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol4
nucleus3
endosome1

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005737cytoplasm IDA19484123
GO:0005829cytosol TAS--

Find genes that share ontologies with RNF135           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for RNF135 About    
See pathways by source

SuperPathContained pathways About
1RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways0.47
TRAF3-dependent IRF activation pathway0.00
Negative regulators of RIG-I/MDA5 signaling0.42
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -100.00
TRAF6 mediated IRF7 activation0.40
2Cytosolic sensors of pathogen-associated DNA
TRAF6 mediated NF-kB activation0.55


Find genes that share SuperPaths with RNF135           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


Selected Reactome Pathways for RNF135 (see all 6)
    NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
TRAF3-dependent IRF activation pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
Negative regulators of RIG-I/MDA5 signaling
TRAF6 mediated IRF7 activation


UniProtKB/Swiss-Prot: RN135_HUMAN, Q8IUD6
Pathway: Protein modification; protein ubiquitination

    Pathway & Disease-focused RT2 Profiler PCR Arrays including RNF135: 

          Mitochondria in human mouse rat
          Ubiquitin Ligases in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for RNF135

STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

Selected Interacting proteins for RNF135 (Q8IUD63 ENSP000003283404) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
InteractantInteraction Details
GeneCardExternal ID(s)
DDX58O957863, ENSP000003692134I2D: score=1 STRING: ENSP00000369213
RARRES3Q9UL193I2D: score=1 
DHX58ENSP000002516424STRING: ENSP00000251642
ISG15ENSP000003686994STRING: ENSP00000368699
MAVSENSP000004019804STRING: ENSP00000401980
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Gene Ontology (GO): 5 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016567protein ubiquitination IDA19017631
GO:0032480negative regulation of type I interferon production TAS--
GO:0032728positive regulation of interferon-beta production IMP19017631
GO:0045087innate immune response TAS--
GO:0045088regulation of innate immune response IMP19017631

Find genes that share ontologies with RNF135           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for RNF135 (RN135)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for RNF135 gene (3 alternative transcripts): 
NM_001184992.1  NM_032322.3  NM_197939.1  

Unigene Cluster for RNF135:

Ring finger protein 135
Hs.29874  [show with all ESTs]
Unigene Representative Sequence: NM_001184992
7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000582674 ENST00000328381(uc010csm.3 uc002hfz.3 uc002hga.3 uc002hgb.3)
ENST00000443677 ENST00000324689 ENST00000535306 ENST00000580444 ENST00000434242

miRNA
Products:
     
Block miRNA regulation of human, mouse, rat RNF135 using miScript Target Protectors
2 qRT-PCR Assays for microRNAs that regulate RNF135:
hsa-miR-124 hsa-miR-506
SwitchGear 3'UTR luciferase reporter plasmidRNF135 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for RNF135
Predesigned siRNA for gene silencing in human, mouse, rat RNF135
Clone
Products:
     
OriGene clones in human, mouse for RNF135 (see all 16)
OriGene ORF clones in mouse, rat for RNF135
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 3): RNF135 (NM_197939)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNF135
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF135
Primer
Products:
    
OriGene qPCR primer pairs and template standards for RNF135
OriGene qSTAR qPCR primer pairs in human, mouse for RNF135
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RNF135
  QuantiTect SYBR Green Assays in human, mouse, rat RNF135
  QuantiFast Probe-based Assays in human, mouse, rat RNF135

Additional mRNA sequence: 

AB470605.1 AJ496729.1 AK122646.1 AK122709.1 AK123549.1 AK226030.1 AK312979.1 AY598332.1 
BC005084.1 BC082262.1 BC126420.1 BC126422.1 BC144143.1 

12 DOTS entries:

DT.95158248  DT.99933218  DT.97818506  DT.91680698  DT.120972995  DT.97858386  DT.120972848  DT.101975503 
DT.91748333  DT.95079728  DT.99955097  DT.100718079 

Selected AceView cDNA sequences (see all 107):

AW769813 AA688090 BM766886 CD518654 BE858801 BE893836 AW083553 BE292712 
AI004323 BQ008551 CB159108 CA748857 NM_197939 AA769314 BC082262 AI299155 
BE858430 AK122646 AK123549 AI609800 AK122709 BC005084 AI810459 AI342639 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for RNF135 (see all 6)    About this scheme

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1:                                                                        
SP2:                                            -                           
SP3:                                -           -                           
SP4:                                -     -     -                           
SP5:                          -     -     -     -                           


ECgene alternative splicing isoforms for RNF135

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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RNF135 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GGTGAGCTAC
RNF135 Expression
About this image

RNF135 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

RNF135 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.29874

UniProtKB/Swiss-Prot: RN135_HUMAN, Q8IUD6
Tissue specificity: Expressed in skeletal muscle, spleen, kidney, placenta, prostate, stomach, thyroid and tongue.
Also weakly expressed in heart, thymus, liver and lung

    Pathway & Disease-focused RT2 Profiler PCR Arrays including RNF135: 
          Mitochondria in human mouse rat
          Ubiquitin Ligases in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for RNF135
OriGene qSTAR qPCR primer pairs in human, mouse for RNF135
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RNF135
QuantiTect SYBR Green Assays in human, mouse, rat RNF135
QuantiFast Probe-based Assays in human, mouse, rat RNF135
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF135

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for RNF135 gene from Selected species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Rnf1351 , 5 ring finger protein 1351, 5 72.98(n)1
61.41(a)1
  11 (47.59 cM)5
719561  NM_028019.31  NP_082295.11 
 801838515 
lizard
(Anolis carolinensis)
Reptilia RNF1356
ring finger protein 135
38(a)
1 ↔ 1
GL343198.1(1572445-1573460)
zebrafish
(Danio rerio)
Actinopterygii AL954746.16
Uncharacterized protein
26(a)
1 ↔ 1
6(19346306-19350099) ENSDARG00000091057


ENSEMBL Gene Tree for RNF135 (if available)
TreeFam Gene Tree for RNF135 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for RNF135 gene
4 SIMAP similar genes for RNF135 using alignment to 4 protein entries:     RN135_HUMAN (see all proteins):
RNF151    BFAR    TRIM3    SH3RF1

Find genes that share paralogs with RNF135           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for RNF135 (see all 497)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 17 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0376524
Macrocephaly, macrosomia, facial dysmorphism syndrome (MMFD)4--see VAR_0376522 R H mis40--------
rs1219181621,2
C,Fpathogenic129325767(+) TCACCG/ACCCAC 4 /H /R mis1 ut311Minor allele frequency- A:0.00NA 4552
rs1475902961,2
--29296169(+) ACCTGC/TCTCAG 3 -- us2k10--------
rs781634031,2
F--29296417(+) TCAGTA/GAGCTG 3 -- us2k11Minor allele frequency- G:0.01WA 118
rs1490783721,2
--29296537(+) TCTCCA/GTAATT 3 -- us2k10--------
rs1147064981,2
C,F--29296582(+) TCAGTC/AGCCTT 3 -- us2k11Minor allele frequency- A:0.02WA 118
rs790576931,2
C--29296656(+) CCTACA/CATGTG 3 -- us2k10--------
rs1483321361,2
C--29296764(+) TTTTC-/TTTTCT 3 -- us2k10--------
rs18100441,2
C--29296784(+) TTTTTC/TTTTTT 3 -- us2k1 trp30--------
rs2008833081,2
--29296784(+) TTTTT-/CTTTTT 3 -- us2k10--------

HapMap Linkage Disequilibrium report for RNF135 (29295803 - 29326929 bp)

Structural Variations
     Database of Genomic Variants (DGV) 5 variations for RNF135:    About this table    
Variant IDTypeSubtypePubMed ID
esv2715813CNV Deletion23290073
nsv833412CNV Loss17160897
nsv457720CNV Loss19166990
esv24402CNV Loss19812545
nsv908056CNV Loss21882294

Human Gene Mutation Database (HGMD): RNF135
Locus Specific Mutation Databases (LSDB): RNF135

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing RNF135
DNA2.0 Custom Variant and Variant Library Synthesis for RNF135

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 611358   
OMIM disorders: 614192  
UniProtKB/Swiss-Prot: RN135_HUMAN, Q8IUD6
  • Macrocephaly, macrosomia, facial dysmorphism syndrome (MMFD) [MIM:614192]: An autosomal dominant disorder
    characterized by the association of macrothrombocytopathy and progressive sensorineural hearing loss without
    renal dysfunction. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 5 diseases for RNF135:    
    About MalaCards
    macrocephaly, macrosomia, facial dysmorphism syndrome    iris hypoplasia and glaucoma    iris hypoplasia    neurofibromatosis
    sotos syndrome

    1 disease from the University of Copenhagen DISEASES database for RNF135:
    Sotos syndrome

    Find genes that share disorders with RNF135           About GenesLikeMe

    Genetic Association Database (GAD): RNF135
    Human Genome Epidemiology (HuGE) Navigator: RNF135 (2 documents)

    Export disorders for RNF135 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RNF135 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with RNF135)
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    1. RNF135 mutations are not present in patients with Sotos syndrome-like features. (PubMed id 19291764)1, 2, 4 Visser R.... Losekoot M. (Am. J. Med. Genet. A 2009)
    2. Riplet/RNF135, a RING finger protein, ubiquitinates RIG-I to promote interferon-beta induction during the early phase of viral infection. (PubMed id 19017631)1, 2, 3 Oshiumi H.... Seya T. (J. Biol. Chem. 2009)
    3. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PubMed id 20546612)1, 4 Zhao J....Grant S.F. (BMC Med. Genet. 2010)
    4. REUL is a novel E3 ubiquitin ligase and stimulator of retinoic-acid- inducible gene-I. (PubMed id 19484123)1, 2 Gao D.... Chen D.Y. (PLoS ONE 2009)
    5. PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4. (PubMed id 19881509)1, 2 You F.... Jiang Z. (Nat. Immunol. 2009)
    6. Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1, 4 Gudbjartsson D.F....Stefansson K. (Nat. Genet. 2008)
    7. Mutations in RNF135, a gene within the NF1 microdeletion region, cause phenotypic abnormalities including overgrowth. (PubMed id 17632510)1, 2 Douglas J.... Rahman N. (Nat. Genet. 2007)
    8. Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer. (PubMed id 15334068)1, 2 Petroziello J.... Carter P. (Oncogene 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84282 HGNC: 21158 AceView: RNF135 Ensembl:ENSG00000181481 euGenes: HUgn84282
    ECgene: RNF135 H-InvDB: RNF135

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RNF135 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RNF135 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RNF135 gene:
    Search GeneIP for patents involving RNF135

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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