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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RNF135 Gene

protein-coding   GIFtS: 59
GCID: GC17P029297

Ring Finger Protein 135

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ring Finger Protein 1351 2 3     riplet1
REUL2 3     MMFD2
Riplet2 3     E3 Ubiquitin-Protein Ligase RNF1352
RIG-I E3 Ubiquitin Ligase2 3     EC 6.3.2.-3

External Ids:    HGNC: 211581   Entrez Gene: 842822   Ensembl: ENSG000001814817   OMIM: 6113585   UniProtKB: Q8IUD63   

Export aliases for RNF135 gene to outside databases

Previous GC identifers: GC17P029147 GC17P029443 GC17P026322 GC17P025508


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RNF135 Gene:
The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally
distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is located
in a chromosomal region known to be frequently deleted in patients with neurofibromatosis. Alternatively spliced
transcript variants encoding distinct isoforms have been reported. (provided by RefSeq, Jul 2008)

GeneCards Summary for RNF135 Gene: 
RNF135 (ring finger protein 135) is a protein-coding gene. Diseases associated with RNF135 include neurofibromatosis, and sotos syndrome, and among its related super-pathways are Immune System and RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways. GO annotations related to this gene include ubiquitin-protein ligase activity and ribonucleoprotein complex binding.

UniProtKB/Swiss-Prot: RN135_HUMAN, Q8IUD6
Function: Acts as an E2-dependent E3 ubiquitin-protein ligase, involved in innate immune defense against viruses.
Ubiquitinates DDX58 and is required for full activation of the DDX58 signaling resulting in interferon beta
production

Gene Wiki entry for RNF135 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010799.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RNF135 gene promoter:
         NF-1   NF-1/L   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNF135 promoter sequence
   Search SABiosciences Chromatin IP Primers for RNF135

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF135


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2   Ensembl cytogenetic band:  17q11.2   HGNC cytogenetic band: 17q11.2

RNF135 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF135 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P029297:  view genomic region     (about GC identifiers)

Start:
29,295,803 bp from pter      End:
29,326,929 bp from pter
Size:
31,127 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RN135_HUMAN, Q8IUD6 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase RNF135  
Size: 432 amino acids; 47888 Da
Subunit: Interacts with DDX58. Interacts with PCBP2
Subcellular location: Cytoplasm
Secondary accessions: A0AVM5 B2R7G9 B6ZLM5 F5GX60 Q9BSE9
Alternative splicing: 3 isoforms:  Q8IUD6-1   Q8IUD6-2   Q8IUD6-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RNF135: NX_Q8IUD6

Explore proteomics data for RNF135 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8IUD6

  • RNF135 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RNF135 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001171921.1  NP_115698.3  NP_922921.1  

    ENSEMBL proteins: 
     ENSP00000328340   ENSP00000411965   ENSP00000323693   ENSP00000440470   ENSP00000464549  
     ENSP00000467799  
    Reactome Protein details: Q8IUD6
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    Cloud-Clone Corp. Proteins for RNF135 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA19484123
    GO:0005829cytosol TAS--

    RNF135 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RNF: RING-type (C3HC4) zinc fingers

    5/8 InterPro protein domains (see all 8):
     IPR006574 PRY
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR001870 B30.2/SPRY
     IPR003877 SPRY_rcpt

    Graphical View of Domain Structure for InterPro Entry Q8IUD6

    ProtoNet protein and cluster: Q8IUD6

    3 Blocks protein domains:
    IPB001841 Zn-finger
    IPB003879 Butyrophylin C-terminal DUF signature
    IPB006574 SPRY-associated domain


    UniProtKB/Swiss-Prot: RN135_HUMAN, Q8IUD6
    Similarity: Contains 1 B30.2/SPRY domain
    Similarity: Contains 1 RING-type zinc finger


    RNF135 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RN135_HUMAN, Q8IUD6
    Function: Acts as an E2-dependent E3 ubiquitin-protein ligase, involved in innate immune defense against viruses.
    Ubiquitinates DDX58 and is required for full activation of the DDX58 signaling resulting in interferon beta
    production

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IDA19484123
    GO:0005515protein binding IPI19017631
    GO:0008270zinc ion binding IEA--
    GO:0043021ribonucleoprotein complex binding IPI19881509
    GO:0046872metal ion binding ----
         
    RNF135 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RNF135:
     Decreased viability with pacli 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RNF135 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Immune System
    Immune System0.56
    Innate Immune System0.50
    2RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways0.52
    Negative regulators of RIG-I/MDA5 signaling0.49
    3TRAF6 mediated IRF7 activation
    TRAF3-dependent IRF activation pathway0.45
    TRAF6 mediated IRF7 activation0.45
    4RIP-mediated NFkB activation via ZBP1
    TRAF6 mediated NF-kB activation0.42
    NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -100.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/8        Reactome Pathways for RNF135 (see all 8)
        NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    TRAF3-dependent IRF activation pathway
    TRAF6 mediated IRF7 activation
    TRAF6 mediated NF-kB activation


    UniProtKB/Swiss-Prot: RN135_HUMAN, Q8IUD6
    Pathway: Protein modification; protein ubiquitination


    RNF135 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNF135

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/11 Interacting proteins for RNF135 (Q8IUD63 ENSP000003283404) via UniProtKB, MINT, STRING, and/or I2D (see all 11)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    DDX58O957863, ENSP000003692134I2D: score=1 STRING: ENSP00000369213
    RARRES3Q9UL193I2D: score=1 
    DHX58ENSP000002516424STRING: ENSP00000251642
    ISG15ENSP000003686994STRING: ENSP00000368699
    MAVSENSP000004019804STRING: ENSP00000401980
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016567protein ubiquitination IDA19017631
    GO:0032480negative regulation of type I interferon production TAS--
    GO:0032728positive regulation of interferon-beta production IMP19017631
    GO:0045087innate immune response TAS--
    GO:0045088regulation of innate immune response IMP19017631

    RNF135 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RNF135 (RN135)

    Search CenterWatch for drugs/clinical trials and news about RNF135 / RN135

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RNF135 gene (3 alternative transcripts): 
    NM_001184992.1  NM_032322.3  NM_197939.1  

    Unigene Cluster for RNF135:

    Ring finger protein 135
    Hs.29874  [show with all ESTs]
    Unigene Representative Sequence: NM_001184992
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000582674 ENST00000328381(uc010csm.3 uc002hfz.3 uc002hga.3 uc002hgb.3)
    ENST00000443677 ENST00000324689 ENST00000535306 ENST00000580444 ENST00000434242

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Additional mRNA sequence: 

    AB470605.1 AJ496729.1 AK122646.1 AK122709.1 AK123549.1 AK226030.1 AK312979.1 AY598332.1 
    BC005084.1 BC082262.1 BC126420.1 BC126422.1 BC144143.1 

    12 DOTS entries:

    DT.95158248  DT.99933218  DT.97818506  DT.91680698  DT.120972995  DT.97858386  DT.120972848  DT.101975503 
    DT.91748333  DT.95079728  DT.99955097  DT.100718079 

    24/107 AceView cDNA sequences (see all 107):

    AK122709 AI366045 BE858430 BG117503 AI342639 BM766886 BE858714 BC082262 
    AW769813 AI299155 AK122646 NM_032322 AA769314 CA748857 AI609800 AI004323 
    CD370706 AW083553 CB159108 BQ007774 BU608620 BE292712 BQ008551 AA688090 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for RNF135 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c
    SP1:                                                                        
    SP2:                                            -                           
    SP3:                                -           -                           
    SP4:                                -     -     -                           
    SP5:                          -     -     -     -                           


    ECgene alternative splicing isoforms for RNF135

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RNF135 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTGAGCTAC
    RNF135 Expression
    About this image


    See RNF135 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RNF135

    SOURCE GeneReport for Unigene cluster: Hs.29874

    UniProtKB/Swiss-Prot: RN135_HUMAN, Q8IUD6
    Tissue specificity: Expressed in skeletal muscle, spleen, kidney, placenta, prostate, stomach, thyroid and tongue.
    Also weakly expressed in heart, thymus, liver and lung

        SABiosciences Expression via Pathway-Focused PCR Arrays including RNF135: 
              Mitochondria in human mouse rat
              Ubiquitin Ligases in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF135

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for RNF135 gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnf1351 , 5 ring finger protein 1351, 5 73.17(n)1
    61.22(a)1
      11 (47.59 cM)5
    719561  NM_028019.31  NP_082295.11 
     801838515 
    lizard
    (Anolis carolinensis)
    Reptilia RNF1356
    ring finger protein 135
    39(a)
    1 ↔ 1
    GL343198.1(1572445-1573460)
    zebrafish
    (Danio rerio)
    Actinopterygii AL954746.16
    Uncharacterized protein
    26(a)
    1 ↔ 1
    6(19346306-19350099)


    ENSEMBL Gene Tree for RNF135 (if available)
    TreeFam Gene Tree for RNF135 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RNF135 gene
    4 SIMAP similar genes for RNF135 using alignment to 4 protein entries:     RN135_HUMAN (see all proteins):
    RNF151    BFAR    TRIM3    SH3RF1

    RNF135 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/497 SNPs in RNF135 are shown (see all 497)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0376524
    Macrocephaly, macrosomia, facial dysmorphism syndrome (MMFD)4--see VAR_0376522 R H mis40--------
    rs1219181621,2
    C,Fpathogenic129325767(+) TCACCG/ACCCAC 4 /H /R mis1 ut311Minor allele frequency- A:0.00NA 4552
    rs1475902961,2
    --29296169(+) ACCTGC/TCTCAG 3 -- us2k10--------
    rs781634031,2
    F--29296417(+) TCAGTA/GAGCTG 3 -- us2k11Minor allele frequency- G:0.01WA 118
    rs1490783721,2
    --29296537(+) TCTCCA/GTAATT 3 -- us2k10--------
    rs1147064981,2
    C,F--29296582(+) TCAGTC/AGCCTT 3 -- us2k11Minor allele frequency- A:0.02WA 118
    rs790576931,2
    C--29296656(+) CCTACA/CATGTG 3 -- us2k10--------
    rs1483321361,2
    C--29296764(+) TTTTC-/TTTTCT 3 -- us2k10--------
    rs18100441,2
    C--29296784(+) TTTTTC/TTTTTT 3 -- us2k1 trp30--------
    rs2008833081,2
    --29296784(+) TTTTT-/CTTTTT 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for RNF135 (29295803 - 29326929 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for RNF135:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2715813CNV Deletion23290073
    nsv833412CNV Loss17160897
    nsv457720CNV Loss19166990
    esv24402CNV Loss19812545
    nsv908056CNV Loss21882294


    Human Gene Mutation Database (HGMD): RNF135

    Locus Specific Mutation Databases (LSDB): RNF135
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611358    OMIM disorders: --

    UniProtKB/Swiss-Prot: RN135_HUMAN, Q8IUD6
  • Macrocephaly, macrosomia, facial dysmorphism syndrome (MMFD) [MIM:614192]: An autosomal dominant disorder
    characterized by the association of macrothrombocytopathy and progressive sensorineural hearing loss without
    renal dysfunction. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 6 diseases for RNF135:    About MalaCards
    neurofibromatosis    sotos syndrome    sensorineural hearing loss    lung cancer
    thyroiditis    prostatitis

    1 disease from the University of Copenhagen DISEASES database for RNF135:
    Sotos syndrome

    RNF135 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RNF135
    Human Genome Epidemiology (HuGE) Navigator: RNF135 (2 documents)

    Export disorders for RNF135 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RNF135 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with RNF135)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. RNF135 mutations are not present in patients with Sotos syndrome-like features. (PubMed id 19291764)1, 2, 4 Visser R....Losekoot M. (2009)
    2. Riplet/RNF135, a RING Finger Protein, Ubiquitinates RIG-I to Promote Interferon-{beta} Induction during the Early Phase of Viral Infection. (PubMed id 19017631)1, 2, 3 Oshiumi H....Seya T. (2009)
    3. The role of height-associated loci identified in geno me wide association studies in the determination of pediatric stature. (PubMed id 20546612)1, 4 Zhao J....Grant S.F. (2010)
    4. REUL is a novel E3 ubiquitin ligase and stimulator of retinoic-acid-inducible gene-I. (PubMed id 19484123)1, 2 Gao D....Chen D.Y. (2009)
    5. PCBP2 mediates degradation of the adaptor MAVS via th e HECT ubiquitin ligase AIP4. (PubMed id 19881509)1, 2 You F....Jiang Z. (2009)
    6. Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1, 4 Gudbjartsson D.F....Stefansson K. (2008)
    7. Mutations in RNF135, a gene within the NF1 microdeletion region, cause phenotypic abnormalities including overgrowth. (PubMed id 17632510)1, 2 Douglas J.... Rahman N. (2007)
    8. Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer. (PubMed id 15334068)1, 2 Petroziello J.... Carter P. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84282 HGNC: 21158 AceView: RNF135 Ensembl:ENSG00000181481 euGenes: HUgn84282
    ECgene: RNF135 H-InvDB: RNF135

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RNF135 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RNF135 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RNF135 gene:
    Search GeneIP for patents involving RNF135

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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