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Aliases for RNF135 Gene

Aliases for RNF135 Gene

  • Ring Finger Protein 135 2 3
  • Riplet 2 3 4
  • RING-Type E3 Ubiquitin Transferase RNF135 3 4
  • RIG-I E3 Ubiquitin Ligase 3 4
  • RING Finger Protein 135 4 5
  • REUL 3 4
  • E3 Ubiquitin-Protein Ligase RNF135 3
  • EC 2.3.2.27 4
  • MMFD 3
  • L13 3

External Ids for RNF135 Gene

Previous GeneCards Identifiers for RNF135 Gene

  • GC17P029147
  • GC17P029443
  • GC17P026322
  • GC17P029297
  • GC17P025508

Summaries for RNF135 Gene

Entrez Gene Summary for RNF135 Gene

  • The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is located in a chromosomal region known to be frequently deleted in patients with neurofibromatosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for RNF135 Gene

RNF135 (Ring Finger Protein 135) is a Protein Coding gene. Diseases associated with RNF135 include Macrocephaly, Macrosomia, Facial Dysmorphism Syndrome and Myopathy Of Extraocular Muscle. Among its related pathways are Innate Immune System and Deubiquitination. GO annotations related to this gene include ligase activity and ribonucleoprotein complex binding.

UniProtKB/Swiss-Prot for RNF135 Gene

  • Acts as an E2-dependent E3 ubiquitin-protein ligase, involved in innate immune defense against viruses. Ubiquitinates DDX58 and is required for full activation of the DDX58 signaling resulting in interferon beta production.

Gene Wiki entry for RNF135 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF135 Gene

Genomics for RNF135 Gene

Regulatory Elements for RNF135 Gene

Enhancers for RNF135 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G031093 1.1 ENCODE 25.2 +136.4 136394 2.8 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 FOS ZNF263 SP3 SMARCB1 ENSG00000264456 RNF135 SUZ12 UTP6 SH3GL1P2 SH3GL1P1 ATAD5 DPRXP4 OMG MIR4733
GH17G031548 1.6 Ensembl ENCODE dbSUPER 10.6 +590.9 590880 2.4 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 CBX5 UTP6 SUZ12 ENSG00000266490 SH3GL1P2 ATAD5 RHBDL3 DPRXP4 RNF135 ENSG00000264456 TEFM
GH17G030697 1.5 Ensembl ENCODE dbSUPER 10.6 -260.8 -260827 1.4 ARID4B SIN3A GLI4 ZNF2 GTF3C2 ZNF121 ZNF143 FOS SP3 REST SUZ12P1 ENSG00000266490 SH3GL1P2 ATAD5 DPRXP4 RNF135 ENSG00000264456 TEFM LRRC37BP1 RN7SL316P
GH17G030905 1.2 ENCODE 13 -52.4 -52398 2.1 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC SUZ12P1 ENSG00000266490 RNF135 ENSG00000264456 LRRC37BP1 UTP6 TEFM ADAP2
GH17G030225 1 ENCODE 14.1 -732.7 -732690 2.4 HDGF FOXA2 AGO1 ZFP64 ARID4B SIN3A GLI4 ZNF48 YY1 GLIS2 CORO6 ENSG00000264456 NUFIP2 SH3GL1P2 ENSG00000266490 RNF135 ENSG00000264290 ANKRD13B ENSG00000252112 DPRXP4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RNF135 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the RNF135 gene promoter:

Genomic Location for RNF135 Gene

Chromosome:
17
Start:
30,958,921 bp from pter
End:
30,999,911 bp from pter
Size:
40,991 bases
Orientation:
Plus strand

Genomic View for RNF135 Gene

Genes around RNF135 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF135 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF135 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF135 Gene

Proteins for RNF135 Gene

  • Protein details for RNF135 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IUD6-RN135_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase RNF135
    Protein Accession:
    Q8IUD6
    Secondary Accessions:
    • A0AVM5
    • B2R7G9
    • B6ZLM5
    • F5GX60
    • Q9BSE9

    Protein attributes for RNF135 Gene

    Size:
    432 amino acids
    Molecular mass:
    47888 Da
    Quaternary structure:
    • Interacts with DDX58. Interacts with PCBP2.

    Alternative splice isoforms for RNF135 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNF135 Gene

Post-translational modifications for RNF135 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RNF135 Gene

Domains & Families for RNF135 Gene

Gene Families for RNF135 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RNF135: view

No data available for UniProtKB/Swiss-Prot for RNF135 Gene

Function for RNF135 Gene

Molecular function for RNF135 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
Acts as an E2-dependent E3 ubiquitin-protein ligase, involved in innate immune defense against viruses. Ubiquitinates DDX58 and is required for full activation of the DDX58 signaling resulting in interferon beta production.

Enzyme Numbers (IUBMB) for RNF135 Gene

Gene Ontology (GO) - Molecular Function for RNF135 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 19484123
GO:0005515 protein binding IPI 19017631
GO:0008270 zinc ion binding IEA --
GO:0016740 transferase activity IEA --
GO:0042802 identical protein binding IPI 25416956
genes like me logo Genes that share ontologies with RNF135: view
genes like me logo Genes that share phenotypes with RNF135: view

Human Phenotype Ontology for RNF135 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for RNF135 Gene

Localization for RNF135 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF135 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNF135 gene
Compartment Confidence
cytosol 5
nucleus 3

Gene Ontology (GO) - Cellular Components for RNF135 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 19484123
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with RNF135: view

Pathways & Interactions for RNF135 Gene

genes like me logo Genes that share pathways with RNF135: view

UniProtKB/Swiss-Prot Q8IUD6-RN135_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for RNF135 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0016579 protein deubiquitination TAS --
GO:0032480 negative regulation of type I interferon production TAS --
GO:0032728 positive regulation of interferon-beta production IMP 19017631
GO:0045087 innate immune response TAS --
genes like me logo Genes that share ontologies with RNF135: view

No data available for SIGNOR curated interactions for RNF135 Gene

Drugs & Compounds for RNF135 Gene

No Compound Related Data Available

Transcripts for RNF135 Gene

Unigene Clusters for RNF135 Gene

Ring finger protein 135:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF135 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1:
SP2: -
SP3: - -
SP4: - - -
SP5: - - - -
SP6: -

Relevant External Links for RNF135 Gene

GeneLoc Exon Structure for
RNF135
ECgene alternative splicing isoforms for
RNF135

Expression for RNF135 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNF135 Gene

mRNA differential expression in normal tissues according to GTEx for RNF135 Gene

This gene is overexpressed in Whole Blood (x5.0).

Protein differential expression in normal tissues from HIPED for RNF135 Gene

This gene is overexpressed in Testis (19.2), Urinary Bladder (17.6), Rectum (16.7), and Monocytes (12.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RNF135 Gene



NURSA nuclear receptor signaling pathways regulating expression of RNF135 Gene:

RNF135

SOURCE GeneReport for Unigene cluster for RNF135 Gene:

Hs.29874

mRNA Expression by UniProt/SwissProt for RNF135 Gene:

Q8IUD6-RN135_HUMAN
Tissue specificity: Expressed in skeletal muscle, spleen, kidney, placenta, prostate, stomach, thyroid and tongue. Also weakly expressed in heart, thymus, liver and lung.

Evidence on tissue expression from TISSUES for RNF135 Gene

  • Nervous system(4.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for RNF135 Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • integumentary
  • nervous
  • skeleton
Organs:
Head and neck:
  • brain
  • eye
  • eyelid
  • face
  • forehead
  • head
  • lip
  • nose
  • skull
General:
  • skin
genes like me logo Genes that share expression patterns with RNF135: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for RNF135 Gene

Orthologs for RNF135 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNF135 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNF135 34 35
  • 98.92 (n)
dog
(Canis familiaris)
Mammalia RNF135 34 35
  • 81.54 (n)
cow
(Bos Taurus)
Mammalia RNF135 34 35
  • 77.75 (n)
rat
(Rattus norvegicus)
Mammalia Rnf135 34
  • 74.15 (n)
mouse
(Mus musculus)
Mammalia Rnf135 34 16 35
  • 72.98 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RNF135 35
  • 38 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RNF135 35
  • 38 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii AL954746.1 35
  • 26 (a)
OneToOne
Species where no ortholog for RNF135 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF135 Gene

ENSEMBL:
Gene Tree for RNF135 (if available)
TreeFam:
Gene Tree for RNF135 (if available)

Paralogs for RNF135 Gene

(4) SIMAP similar genes for RNF135 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with RNF135: view

No data available for Paralogs for RNF135 Gene

Variants for RNF135 Gene

Sequence variations from dbSNP and Humsavar for RNF135 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs121918162 Pathogenic, Macrocephaly, macrosomia, facial dysmorphism syndrome (MMFD) [MIM:614192] 30,998,749(+) TCACC(A/G)CCCAC reference, missense, utr-variant-3-prime
rs121918161 Pathogenic 30,997,289(+) CTGAC(C/T)AGAGC reference, synonymous-codon, stop-gained
rs724159977 Pathogenic 30,997,304(+) CTGCA(-/C)TCAGG reference, frameshift-variant
rs724159978 Pathogenic 30,998,907(+) ACCAG(-/G)TCCTG reference, utr-variant-3-prime, frameshift-variant
rs886042696 Uncertain significance 30,998,793(+) CCAGC(-/C)AGGTC reference, utr-variant-3-prime, frameshift-variant

Structural Variations from Database of Genomic Variants (DGV) for RNF135 Gene

Variant ID Type Subtype PubMed ID
esv24402 CNV loss 19812545
esv2715813 CNV deletion 23290073
nsv457720 CNV loss 19166990
nsv833412 CNV loss 17160897

Variation tolerance for RNF135 Gene

Residual Variation Intolerance Score: 57.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.06; 84.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNF135 Gene

Human Gene Mutation Database (HGMD)
RNF135
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNF135

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF135 Gene

Disorders for RNF135 Gene

MalaCards: The human disease database

(3) MalaCards diseases for RNF135 Gene - From: OMIM, ClinVar, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
macrocephaly, macrosomia, facial dysmorphism syndrome
  • macrocephaly, macrosomia, and facial dysmorphism syndrome
myopathy of extraocular muscle
  • myopathy of extraocular muscles
sotos syndrome 1
  • sotos syndrome
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

RN135_HUMAN
  • Macrocephaly, macrosomia, facial dysmorphism syndrome (MMFD) [MIM:614192]: An autosomal dominant disorder characterized by the association of macrothrombocytopathy and progressive sensorineural hearing loss without renal dysfunction. {ECO:0000269 PubMed:17632510}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for RNF135

Genetic Association Database (GAD)
RNF135
Human Genome Epidemiology (HuGE) Navigator
RNF135
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RNF135
genes like me logo Genes that share disorders with RNF135: view

No data available for Genatlas for RNF135 Gene

Publications for RNF135 Gene

  1. Riplet/RNF135, a RING finger protein, ubiquitinates RIG-I to promote interferon-beta induction during the early phase of viral infection. (PMID: 19017631) Oshiumi H. … Seya T. (J. Biol. Chem. 2009) 2 3 4 64
  2. RNF135 mutations are not present in patients with Sotos syndrome-like features. (PMID: 19291764) Visser R. … Losekoot M. (Am. J. Med. Genet. A 2009) 3 4 46 64
  3. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PMID: 20546612) Zhao J. … Grant S.F. (BMC Med. Genet. 2010) 3 46 64
  4. PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4. (PMID: 19881509) You F. … Jiang Z. (Nat. Immunol. 2009) 3 4 64
  5. REUL is a novel E3 ubiquitin ligase and stimulator of retinoic-acid- inducible gene-I. (PMID: 19484123) Gao D. … Chen D.Y. (PLoS ONE 2009) 3 4 64

Products for RNF135 Gene

Sources for RNF135 Gene

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