RNF133 Gene
protein-coding GIFtS: 41
GCID: GC07M122337
|
|
ring finger protein 133
| |
Aliases
for RNF133 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ring Finger Protein 1331 2 3 | | E3 Ubiquitin-Protein Ligase RNF1332 | | EC 6.3.2.-3 |
Export aliases for RNF133 gene to outside databasesPrevious GC identifers: GC07M121878 GC07M121892 GC07M121931 GC07M122125 GC07M116700 |
Summaries
for RNF133 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RNF133:
The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinctproteins and known to be involved in protein-protein and protein-DNA interactions. This gene has no intron. (providedby RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: RN133_HUMAN, Q8WVZ7Function: Has E3 ubiquitin-protein ligase activity (By similarity)
|
Genomic Views
for RNF133 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079596.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RNF133 gene promoter:
Max1 FOXF2 POU3F2 (N-Oct-5b) CUTL1 Nkx2-5 POU3F2 Tal-1beta E47 Nkx6-1 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for RNF133
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF133 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q31.32 Ensembl cytogenetic band: 7q31.32 HGNC cytogenetic band: 7q31.33RNF133 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M122337: view genomic region
(about GC identifiers)
Start:
|
122,337,766 bp from pter |
End:
|
122,339,210 bp from pter |
Size:
|
1,445 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 121,732,467-121,733,909 |
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Proteins
for RNF133 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RN133_HUMAN, Q8WVZ7 (See
protein sequence)Recommended Name: E3 ubiquitin-protein ligase RNF133 Size: 376 amino acids; 42294 Da
Subcellular location: Endoplasmic reticulum membrane; Single-pass membrane protein (By similarity)
Secondary accessions: A4D0W2 Q8N7G7Explore the universe of human proteins at neXtProt for RNF133: NX_Q8WVZ7
Post-translational modifications:
Auto-ubiquitinated (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8WVZ7
RNF133 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_631914.1
ENSEMBL proteins: ENSP00000344489
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005789 | endoplasmic reticulum membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
RNF133 for ontologies About GeneDecksing
RNF133 Antibody Products:
Assay Products for RNF133: |
Protein
Domains /
Families
for RNF133 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RNF133 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8WVZ7ProtoNet protein and cluster: Q8WVZ7 2 Blocks protein families: IPB001841 Zn-finger IPB003137 Protease-associated PA
UniProtKB/Swiss-Prot: RN133_HUMAN, Q8WVZ7Similarity: Contains 1 PA (protease associated) domainSimilarity: Contains 1 RING-type zinc finger |
Function
for RNF133 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RN133_HUMAN, Q8WVZ7Function: Has E3 ubiquitin-protein ligase activity (By similarity)Enzyme Number (IUBMB): EC 6.3.2.-1
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF133
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF133 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008270 | zinc ion binding |
IEA | -- | | GO:0016874 | ligase activity |
IEA | -- |
RNF133 for ontologies About GeneDecksing
|
Pathways & Interactions
for RNF133 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
UniProtKB/Swiss-Prot: RN133_HUMAN, Q8WVZ7Pathway: Protein modification; protein ubiquitinationInteractions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNF133
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for RNF133 (Q8WVZ73 ENSP000003444894) via UniProtKB, MINT, STRING, and/or I2D About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0051865 | protein autoubiquitination |
IEA | -- |
RNF133 for ontologies About GeneDecksing
|
Drugs & Compounds
for RNF133 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RNF133
Search CenterWatch for drugs/clinical trials and news about RNF133 / RN133
|
Transcripts
for RNF133 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RNF133 gene: NM_139175.1 Unigene Cluster for RNF133: Ring finger protein 133 Hs.126730 [show with all ESTs]Unigene Representative Sequence: AF4475891 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000340112(uc003vkj.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF133 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF133
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RNF133 (NM_139175) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RNF133 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF133 |
Additional cDNA sequence: AF447589.1 AK098524.1 BC022038.2 1 DOTS entry: DT.106052 24/28 AceView cDNA sequences (see all 28): BI829821 AK098524 BX089015 AA897680 CD171672 BC022038 BI828570 BP368855 BP368911 BP368988 BI830727 BP368897 BG723185 BE500941 AI969336 BE500949 BI829237 AA906730 NM_139175 AF447589 BP369600 AW273800 AA922265 AA916967
GeneLoc Exon Structure
|
Expression
for RNF133 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RNF133 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTTTTGAGG
About this image
See RNF133 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RNF133
SOURCE GeneReport for Unigene cluster: Hs.126730
SABiosciences Custom PCR Arrays for RNF133
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNF133
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RNF133 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNF133 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNF133 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF133 |
Orthologs
for RNF133 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for RNF133 gene from 4/13 species (see all 13) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
43(a) |
1 → many |
5(68088786-68089649) |
zebrafish
(Danio rerio) |
Actinopterygii |
rnf128a6si:dkeyp-86f7.46 |
si:dkeyp-86f7.4 |
34(a)29(a) |
many ↔ manymany ↔ many |
5(25346355-25365861) 14(9604773-9619261) |
fruit fly
(Drosophila melanogaster) |
Insecta |
gol6 |
goliath |
16(a) |
1 → many |
2R(20960150-20971843) |
worm
(Caenorhabditis elegans) |
Secernentea |
H10E21.56 |
Protein H10E21.5 |
12(a) |
1 → many |
III(20527-23962) |
ENSEMBL Gene Tree for RNF133 (if available)
TreeFam Gene Tree for RNF133 (if available) |
Paralogs
for RNF133 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RNF133 gene
- ZNRF32 RNF432 RNF1482 RNF1492 RNF1672 RNF1302 RNF1502 RNF2152
- RNF1282 ZNRF42 RNF132
5 SIMAP similar genes for RNF133 using alignment to 1 protein entry: RN133_HUMAN:RNF148 RNF128 RNF130 RNF150 RNF149
RNF133 for paralogs About GeneDecksing
|
Genomic Variants
for RNF133 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNF133 |
|
Disorders
/ Diseases
for RNF133 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 RNF133 for disorders About MalaCards
RNF133 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: RNF133 (1 document)
Export disorders for RNF133 gene to outside databases
|
Publications
for RNF133 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RNF133 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with RNF133) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. (PubMed id 19549727)1 Markson G....Sanderson C.M. (2009)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1 Scherer S.W.... Tsui L.-C. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
- Toward a complete human genome sequence. (PubMed id 9847074)1 Wilson R. (1998)
|
External Searches for RNF133 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RNF133 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RNF133 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RNF133 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RNF133 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RNF133 gene:
Search GeneIP for patents involving RNF133
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RNF133 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | RNF133 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF133 |
|  |  |  | | | | Search ThermoFisher Antibodies for RNF133 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF133 |
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