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RNF133 Gene

protein-coding   GIFtS: 44
GCID: GC07M122337

Ring Finger Protein 133

  Search for RNF133
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ring Finger Protein 1331 2 3
E3 Ubiquitin-Protein Ligase RNF1332
EC 6.3.2.-3

External Ids:    HGNC: 211541   Entrez Gene: 1684332   Ensembl: ENSG000001880507   UniProtKB: Q8WVZ73   

Export aliases for RNF133 gene to outside databases

Previous GC identifers: GC07M121878 GC07M121892 GC07M121931 GC07M122125 GC07M116700


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RNF133 Gene:
The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally
distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene has no
intron. (provided by RefSeq, Jul 2008)

GeneCards Summary for RNF133 Gene:
RNF133 (ring finger protein 133) is a protein-coding gene. GO annotations related to this gene include ligase activity. An important paralog of this gene is ZNRF3.

UniProtKB/Swiss-Prot: RN133_HUMAN, Q8WVZ7
Function: Has E3 ubiquitin-protein ligase activity (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the RNF133 gene promoter:
         Max1   FOXF2   POU3F2 (N-Oct-5b)   CUTL1   Nkx2-5   POU3F2   Tal-1beta   E47   Nkx6-1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNF133 promoter sequence
   Search Chromatin IP Primers for RNF133

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNF133


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q31.32   Ensembl cytogenetic band:  7q31.32   HGNC cytogenetic band: 7q31.33

RNF133 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF133 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M122337:  view genomic region     (about GC identifiers)

Start:
122,337,766 bp from pter      End:
122,339,210 bp from pter
Size:
1,445 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 121,732,467-121,733,909     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RN133_HUMAN, Q8WVZ7 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase RNF133  
Size: 376 amino acids; 42294 Da
Secondary accessions: A4D0W2 Q8N7G7

Explore the universe of human proteins at neXtProt for RNF133: NX_Q8WVZ7

Explore proteomics data for RNF133 at MOPED

Post-translational modifications: 

  • Auto-ubiquitinated (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RNF133 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_631914.1  
    ENSEMBL proteins: 
     ENSP00000344489  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers

    3 InterPro protein domains:
     IPR001841 Znf_RING
     IPR003137 Protease-assoc_domain
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q8WVZ7

    ProtoNet protein and cluster: Q8WVZ7

    2 Blocks protein domains:
    IPB001841 Zn-finger
    IPB003137 Protease-associated PA


    UniProtKB/Swiss-Prot: RN133_HUMAN, Q8WVZ7
    Similarity: Contains 1 PA (protease associated) domain
    Similarity: Contains 1 RING-type zinc finger


    RNF133 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RN133_HUMAN, Q8WVZ7
    Function: Has E3 ubiquitin-protein ligase activity (By similarity)

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0016874ligase activity IEA--
    GO:0046872metal ion binding ----
         
    RNF133 for ontologies           About GeneDecksing


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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RN133_HUMAN, Q8WVZ7: Endoplasmic reticulum membrane; Single-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    extracellular2
    cytoskeleton1
    cytosol1
    golgi apparatus1
    lysosome1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral component of membrane IEA--

    RNF133 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    UniProtKB/Swiss-Prot: RN133_HUMAN, Q8WVZ7
    Pathway: Protein modification; protein ubiquitination

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RNF133
    Interactions:

        Search GeneGlobe Interaction Network for RNF133

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for RNF133 (Q8WVZ73 ENSP000003444894) via UniProtKB, MINT, STRING, and/or I2D

    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE2IP632793, ENSP000003248974I2D: score=2 STRING: ENSP00000324897
    UBE2HP622563, ENSP000003478364I2D: score=2 STRING: ENSP00000347836
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0051865protein autoubiquitination IEA--

    RNF133 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for RNF133 (RN133)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RNF133 gene: 
    NM_139175.1  

    Unigene Cluster for RNF133:

    Ring finger protein 133
    Hs.126730  [show with all ESTs]
    Unigene Representative Sequence: AF447589
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000340112(uc003vkj.1)
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    Additional mRNA sequence: 

    AF447589.1 AK098524.1 BC022038.2 

    1 DOTS entry:

    DT.106052 

    Selected AceView cDNA sequences (see all 28):

    BX089015 BI828570 AA897680 CD171672 BI829821 AK098524 BC022038 BE500941 
    NM_139175 AA906730 BE500949 BP369600 AI969336 BP368855 BP368897 BI829237 
    BP368911 AF447589 BP368988 BI830727 BG723185 AW273800 AA922265 AA916967 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RNF133 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTTTTGAGG
    RNF133 Expression
    About this image

    RNF133 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RNF133 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.126730
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RNF133 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnf1331 , 5 ring finger protein 1331, 5 81.02(n)1
    74.1(a)1
      6 (11.01 cM)5
    3866111  NM_198251.21  NP_937894.11 
     236488695 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    39(a)
    1 → many
    4(17287798-17328258)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    35(a)
    1 → many
    GL343842.1(8227-32438)
    zebrafish
    (Danio rerio)
    Actinopterygii rnf128a6
    si:dkeyp-86f7.46
    si:dkeyp-86f7.4
    35(a)
    30(a)
    many ↔ many
    many ↔ many
    5(25346355-25365861) ENSDARG00000016867
    14(9604773-9619261) ENSDARG00000029890
    worm
    (Caenorhabditis elegans)
    Secernentea H10E21.56
    Protein H10E21.5 (H10E21.5) mRNA, complete cds
    15(a)
    1 → many
    III(20527-23962) WBGene00019185


    ENSEMBL Gene Tree for RNF133 (if available)
    TreeFam Gene Tree for RNF133 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RNF133 gene
    ZNRF32  RNF432  RNF1482  RNF1492  RNF1502  RNF1302  RNF1672  RNF2152  
    RNF1282  ZNRF42  RNF132  
    5 SIMAP similar genes for RNF133 using alignment to 1 protein entry:     RN133_HUMAN:
    RNF148    RNF128    RNF130    RNF150    RNF149

    RNF133 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RNF133
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    RNF133 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RNF133
    Human Genome Epidemiology (HuGE) Navigator: RNF133 (1 document)

    Export disorders for RNF133 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RNF133 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with RNF133)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    5. Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. (PubMed id 19549727)1 Markson G....Sanderson C.M. (Genome Res. 2009)
    6. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    7. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1 Scherer S.W.... Tsui L.-C. (Science 2003)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    9. Toward a complete human genome sequence. (PubMed id 9847074)1 Sulston J.E. and Waterston R. (Genome Res. 1998)
    10. Does this have a familiar RING? (PubMed id 8744354)1 Saurin A.J....Freemont P.S. (Trends Biochem. Sci. 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 168433 HGNC: 21154 AceView: RNF133 Ensembl:ENSG00000188050 euGenes: HUgn168433
    ECgene: RNF133 H-InvDB: RNF133

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RNF133 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RNF133 gene:
    Search GeneIP for patents involving RNF133

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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