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Aliases for RNF133 Gene

Aliases for RNF133 Gene

  • Ring Finger Protein 133 2 3
  • RING Finger Protein 133 4 5
  • EC 6.3.2.- 4

External Ids for RNF133 Gene

Previous GeneCards Identifiers for RNF133 Gene

  • GC07M121878
  • GC07M121892
  • GC07M121931
  • GC07M122125
  • GC07M122337
  • GC07M116700

Summaries for RNF133 Gene

Entrez Gene Summary for RNF133 Gene

  • The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene has no intron. [provided by RefSeq, Jul 2008]

GeneCards Summary for RNF133 Gene

RNF133 (Ring Finger Protein 133) is a Protein Coding gene. GO annotations related to this gene include ligase activity. An important paralog of this gene is RNF167.

UniProtKB/Swiss-Prot for RNF133 Gene

  • Has E3 ubiquitin-protein ligase activity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF133 Gene

Genomics for RNF133 Gene

Regulatory Elements for RNF133 Gene

Enhancers for RNF133 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RNF133 on UCSC Golden Path with GeneCards custom track

Genomic Location for RNF133 Gene

122,697,712 bp from pter
122,699,156 bp from pter
1,445 bases
Minus strand

Genomic View for RNF133 Gene

Genes around RNF133 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF133 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF133 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF133 Gene

Proteins for RNF133 Gene

  • Protein details for RNF133 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    E3 ubiquitin-protein ligase RNF133
    Protein Accession:
    Secondary Accessions:
    • A4D0W2
    • Q8N7G7

    Protein attributes for RNF133 Gene

    376 amino acids
    Molecular mass:
    42294 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RNF133 Gene

Proteomics data for RNF133 Gene at MOPED

Post-translational modifications for RNF133 Gene

Other Protein References for RNF133 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RNF133 Gene

Domains & Families for RNF133 Gene

Gene Families for RNF133 Gene

Protein Domains for RNF133 Gene

Suggested Antigen Peptide Sequences for RNF133 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 PA (protease associated) domain.
  • Contains 1 RING-type zinc finger.
  • Contains 1 PA (protease associated) domain.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF133: view

Function for RNF133 Gene

Molecular function for RNF133 Gene

UniProtKB/Swiss-Prot Function:
Has E3 ubiquitin-protein ligase activity.

Enzyme Numbers (IUBMB) for RNF133 Gene

Gene Ontology (GO) - Molecular Function for RNF133 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with RNF133: view
genes like me logo Genes that share phenotypes with RNF133: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RNF133 Gene

Localization for RNF133 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF133 Gene

Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for RNF133 Gene COMPARTMENTS Subcellular localization image for RNF133 gene
Compartment Confidence
endoplasmic reticulum 4
extracellular 2
cytoskeleton 1
cytosol 1
golgi apparatus 1
lysosome 1
mitochondrion 1
peroxisome 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for RNF133 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RNF133: view

Pathways & Interactions for RNF133 Gene

SuperPathways for RNF133 Gene

No Data Available

UniProtKB/Swiss-Prot Q8WVZ7-RN133_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for RNF133 Gene


No data available for Pathways by source and SIGNOR curated interactions for RNF133 Gene

Drugs & Compounds for RNF133 Gene

No Compound Related Data Available

Transcripts for RNF133 Gene

mRNA/cDNA for RNF133 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(28) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RNF133 Gene

Ring finger protein 133:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNF133 Gene

No ASD Table

Relevant External Links for RNF133 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNF133 Gene

mRNA expression in normal human tissues for RNF133 Gene

mRNA differential expression in normal tissues according to GTEx for RNF133 Gene

This gene is overexpressed in Testis (x44.8).

Protein differential expression in normal tissues from HIPED for RNF133 Gene

This gene is overexpressed in Frontal cortex (62.8) and Ovary (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RNF133 Gene

SOURCE GeneReport for Unigene cluster for RNF133 Gene Hs.126730

genes like me logo Genes that share expression patterns with RNF133: view

Protein tissue co-expression partners for RNF133 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for RNF133 Gene

Orthologs for RNF133 Gene

This gene was present in the common ancestor of animals.

Orthologs for RNF133 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RNF133 35
  • 83.07 (n)
  • 77.39 (a)
(Canis familiaris)
Mammalia RNF133 35
  • 68.59 (n)
  • 68.41 (a)
(Mus musculus)
Mammalia Rnf133 35
  • 81.02 (n)
  • 74.1 (a)
Rnf133 16
Rnf133 36
  • 73 (a)
(Pan troglodytes)
Mammalia RNF133 35
  • 99.65 (n)
  • 99.47 (a)
(Rattus norvegicus)
Mammalia Rnf133 35
  • 80.8 (n)
  • 72.8 (a)
(Gallus gallus)
Aves -- 36
  • 39 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 35 (a)
(Danio rerio)
Actinopterygii rnf128a 36
  • 35 (a)
si:dkeyp-86f7.4 36
  • 30 (a)
(Caenorhabditis elegans)
Secernentea H10E21.5 36
  • 15 (a)
Species with no ortholog for RNF133:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RNF133 Gene

Gene Tree for RNF133 (if available)
Gene Tree for RNF133 (if available)

Paralogs for RNF133 Gene

(5) SIMAP similar genes for RNF133 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RNF133: view

Variants for RNF133 Gene

Variation tolerance for RNF133 Gene

Residual Variation Intolerance Score: 62.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.90; 48.77% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for RNF133 Gene

Disorders for RNF133 Gene

Relevant External Links for RNF133

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RNF133 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF133 Gene

Publications for RNF133 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects. (PMID: 24324551) Deng X. … Seielstad M. (PLoS ONE 2013) 3
  3. Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. (PMID: 19549727) Markson G. … Sanderson C.M. (Genome Res. 2009) 3
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for RNF133 Gene

Sources for RNF133 Gene