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RNF130 Gene

protein-coding   GIFtS: 52
GCID: GC05M179345

Ring Finger Protein 130

  See RNF130-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ring Finger Protein 1301 2 3     G1-Related Zinc Finger Protein2
Goliath Homolog2 3     EC 6.3.2.-3
G1RZFP2     H-Goliath3
GOLIATH2     EC 2.1.18
GP2     EC 6.3.28
E3 Ubiquitin-Protein Ligase RNF1302     

External Ids:    HGNC: 182801   Entrez Gene: 558192   Ensembl: ENSG000001132697   UniProtKB: Q86XS83   

Export aliases for RNF130 gene to outside databases

Previous GC identifers: GC05M179446 GC05M179492 GC05M179315 GC05M179382 GC05M174107


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RNF130 Gene:
The protein encoded by this gene contains a RING finger motif and is similar to g1, a Drosophila zinc-finger
protein that is expressed in mesoderm and involved in embryonic development. The expression of the mouse
counterpart was found to be upregulated in myeloblastic cells following IL3 deprivation, suggesting that this
gene may regulate growth factor withdrawal-induced apoptosis of myeloid precursor cells. Alternative splicing
results in multiple transcript variants. (provided by RefSeq, Jul 2013)

GeneCards Summary for RNF130 Gene:
RNF130 (ring finger protein 130) is a protein-coding gene. Diseases associated with RNF130 include gestational trophoblastic neoplasm, and trophoblastic neoplasm. GO annotations related to this gene include ubiquitin-protein ligase activity. An important paralog of this gene is ZNRF3.

UniProtKB/Swiss-Prot: GOLI_HUMAN, Q86XS8
Function: May have a role during the programmed cell death of hematopoietic cells (By similarity). Acts as an E3
ubiquitin-protein ligase




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_023133.14  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RNF130 gene promoter:
         c-Fos   AP-1   ATF-2   CUTL1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNF130 promoter sequence
   Search Chromatin IP Primers for RNF130

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNF130


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.3   Ensembl cytogenetic band:  5q35.3   HGNC cytogenetic band: 5q35.3

RNF130 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF130 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M179345:  view genomic region     (about GC identifiers)

Start:
179,338,651 bp from pter      End:
179,499,118 bp from pter
Size:
160,468 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GOLI_HUMAN, Q86XS8 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase RNF130 precursor  
Size: 419 amino acids; 46405 Da
Sequence caution: Sequence=AAF67007.1; Type=Frameshift; Positions=110, 116;
Secondary accessions: Q32P32 Q641P9 Q6P177 Q7L2U2 Q9P0J9

Explore the universe of human proteins at neXtProt for RNF130: NX_Q86XS8

Explore proteomics data for RNF130 at MOPED

Post-translational modifications: 

  • In vivo measurements suggest this protein is glycosylated (PubMed:19159218). In contrast, in vitro experiments
    failed to detect glycosylation (PubMed:16549277)1
  • Ubiquitination2 at Lys310
  • Glycosylation2 at Asn29, Asn40, Asn112, Asn135, Asn172, Asn189
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for RNF130 (Q86XS8)
     AVGTRMP  RILPCKH 


    See RNF130 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001267730.1  NP_060904.2  

    ENSEMBL proteins: 
     ENSP00000429509   ENSP00000430237   ENSP00000261947   ENSP00000430999  

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    Cloud-Clone Corp. Proteins for RNF130

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers

    3 InterPro protein domains:
     IPR001841 Znf_RING
     IPR003137 Protease-assoc_domain
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q86XS8

    ProtoNet protein and cluster: Q86XS8

    2 Blocks protein domains:
    IPB001841 Zn-finger
    IPB003137 Protease-associated PA


    UniProtKB/Swiss-Prot: GOLI_HUMAN, Q86XS8
    Similarity: Contains 1 PA (protease associated) domain
    Similarity: Contains 1 RING-type zinc finger


    Find genes that share domains with RNF130           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GOLI_HUMAN, Q86XS8
    Function: May have a role during the programmed cell death of hematopoietic cells (By similarity). Acts as an E3
    ubiquitin-protein ligase

         Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22 EC 2.1.12

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IDA16549277
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0046872metal ion binding ----
         
    Find genes that share ontologies with RNF130           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for RNF130:
     G0/1 arrest  Increased G1 DNA content  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RNF130
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    miRTarBase miRNAs that target RNF130:
    hsa-mir-320a (MIRT044645)

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    8 qRT-PCR Assays for microRNAs that regulate RNF130:
    hsa-miR-644 hsa-miR-520d-5p hsa-miR-147 hsa-miR-374c hsa-miR-655 hsa-miR-524-5p hsa-miR-590-3p hsa-miR-509-3p
    SwitchGear 3'UTR luciferase reporter plasmidRNF130 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RNF130

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GOLI_HUMAN, Q86XS8: Membrane; Single-pass type I membrane protein (Potential). Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol3
    plasma membrane3
    endoplasmic reticulum1
    extracellular1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with RNF130           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    UniProtKB/Swiss-Prot: GOLI_HUMAN, Q86XS8
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Array including RNF130: 

              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RNF130

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    Selected Interacting proteins for RNF130 (Q86XS82, 3 ENSP000002619474) via UniProtKB, MINT, STRING, and/or I2D (see all 582)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE2NP610882, 3, ENSP000003161764MINT-7947479 I2D: score=1 STRING: ENSP00000316176
    SCN2AQ992502, 3MINT-64837 I2D: score=3 
    TTLL3Q9Y4R72, 3MINT-64838 I2D: score=1 
    UBE2D2P628373, ENSP000003817174I2D: score=1 STRING: ENSP00000381717
    UBE2E1P519653, ENSP000003037094I2D: score=1 STRING: ENSP00000303709
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0012501programmed cell death ISS13679316

    Find genes that share ontologies with RNF130           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RNF130 (GOLI)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RNF130 gene (2 alternative transcripts): 
    NM_001280801.1  NM_018434.5  

    Unigene Cluster for RNF130:

    Ring finger protein 130
    Hs.484363  [show with all ESTs]
    Unigene Representative Sequence: AL831873
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000522208 ENST00000521389(uc003mll.1 uc003mlm.1) ENST00000261947
    ENST00000520564 ENST00000521901 ENST00000520911 ENST00000519708 ENST00000523487

    miRNA
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    8 qRT-PCR Assays for microRNAs that regulate RNF130:
    hsa-miR-644 hsa-miR-520d-5p hsa-miR-147 hsa-miR-374c hsa-miR-655 hsa-miR-524-5p hsa-miR-590-3p hsa-miR-509-3p
    SwitchGear 3'UTR luciferase reporter plasmidRNF130 3' UTR sequence
    Inhib. RNA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RNF130
      QuantiTect SYBR Green Assays in human, mouse, rat RNF130
      QuantiFast Probe-based Assays in human, mouse, rat RNF130

    Additional mRNA sequence: 

    AB209800.1 AF155650.1 AK313089.1 AL831873.1 AY083998.1 BC017100.1 BC065244.1 BC082267.1 
    BC108306.1 BC113864.1 BC114472.1 

    16 DOTS entries:

    DT.446422  DT.99982777  DT.100824260  DT.120830785  DT.75100535  DT.120830787  DT.100726855  DT.120830770 
    DT.91797153  DT.100824264  DT.120830764  DT.120830809  DT.91926559  DT.100824262  DT.121630433  DT.40248353 

    Selected AceView cDNA sequences (see all 446):

    BE645725 AI200736 AW131613 AI567085 BG055457 AI769946 AW024979 AI583987 
    CA944924 CB241498 BM709172 AA430360 BQ774793 CA422830 D79226 BM723499 
    BM021495 BE048710 AW299944 AW612601 BU608590 BX333053 AY083998 AI719360 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for RNF130    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
    SP1:                                -                                   -         
    SP2:              -     -           -                                   -         
    SP3:                                -                             -     -         
    SP4:                                                                              
    SP5:                                                                              


    ECgene alternative splicing isoforms for RNF130

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RNF130 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCACACAAGC
    RNF130 Expression
    About this image


    RNF130 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Lung (Respiratory System)
     
     Ovary (Reproductive System)
     
     Adipose (Muscoskeletal System)
     
     Liver (Hepatobiliary System)
    RNF130 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RNF130 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.484363

    UniProtKB/Swiss-Prot: GOLI_HUMAN, Q86XS8
    Tissue specificity: Ubiquitously expressed. Highly expressed in leukocytes. Not expressed in erythroblasts

        Pathway & Disease-focused RT2 Profiler PCR Array including RNF130: 
              Ubiquitin Ligases in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF130

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RNF130 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnf1301 , 5 ring finger protein 1301, 5 93.16(n)1
    98.09(a)1
      11 (30.16 cM)5
    590441  NM_021540.31  NP_067515.21 
     500253465 
    chicken
    (Gallus gallus)
    Aves RNF1301 ring finger protein 130 80.5(n)
    83.75(a)
      416281  XM_414601.4  XP_414601.3 
    lizard
    (Anolis carolinensis)
    Reptilia RNF1306
    ring finger protein 130
    81(a)
    1 ↔ 1
    2(139983859-140046307)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.337632 Xenopus laevis transcribed sequence with weak similarity more 78.2(n)    BJ088082.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc14g022 wufc14g02 77.9(n)   323940  57053425 
    worm
    (Caenorhabditis elegans)
    Secernentea H10E21.56
    Protein H10E21.5 (H10E21.5) mRNA, complete cds
    22(a)
    1 → many
    III(20527-23962) WBGene00019185


    ENSEMBL Gene Tree for RNF130 (if available)
    TreeFam Gene Tree for RNF130 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RNF130 gene
    ZNRF32  RNF432  RNF1482  RNF1492  RNF1332  RNF1502  RNF1672  RNF2152  
    RNF1282  ZNRF42  RNF132  
    7 SIMAP similar genes for RNF130 using alignment to 5 protein entries:     GOLI_HUMAN (see all proteins):
    RNF150    RNF128    RNF149    RNF13    RNF133    RNF148
    LOC284996

    Find genes that share paralogs with RNF130           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RNF130 (see all 2213)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1478430671,2
    --179382041(+) TGGTTC/TGGAAA 1 -- ds50010--------
    rs1172006991,2
    F--179382136(+) CAGTGG/AGGAGC 1 -- ds50011Minor allele frequency- A:0.01EA 120
    rs1403798921,2
    C--179382152(+) TTACAA/CGTCCC 1 -- ds50010--------
    rs1816937831,2
    --179382215(+) AATTAA/TCACAG 1 -- ds50010--------
    rs1441371071,2
    C--179382216(+) ATTAT-/CACAGAG 1 -- ds50010--------
    rs1856778271,2
    --179382361(+) TTCCTC/TTCACG 1 -- ds50010--------
    rs123324691,2
    C,F,H--179382594(+) ATGCAC/TAAAAA 1 -- ut319Minor allele frequency- T:0.07NS EA WA 1204
    rs1912163271,2
    --179382847(+) CTGCAA/GTTGAC 1 -- int10--------
    rs1811433801,2
    --179382862(+) TCATCC/TATCTT 1 -- int10--------
    rs32095711,2
    F--179382920(-) CAACAC/TGCCAT 1 -- int11Minor allele frequency- T:0.00MN 184

    HapMap Linkage Disequilibrium report for RNF130 (179338651 - 179499118 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for RNF130:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2731315CNV Deletion23290073
    esv2731313CNV Deletion23290073
    esv2731314CNV Deletion23290073
    esv2674593CNV Deletion23128226
    nsv830561CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases for RNF130:    
    About MalaCards
    gestational trophoblastic neoplasm    trophoblastic neoplasm

    1 disease from the University of Copenhagen DISEASES database for RNF130:
    Gestational trophoblastic neoplasm

    Find genes that share disorders with RNF130           About GenesLikeMe

    Genetic Association Database (GAD): RNF130

    Export disorders for RNF130 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RNF130 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with RNF130)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. (PubMed id 21347282)1, 4 Lettre G....Boerwinkle E. (PLoS Genet. 2011)
    2. h-Goliath, paralog of GRAIL, is a new E3 ligase protein, expressed in human leukocytes. (PubMed id 16549277)1, 2 Guais A.... Bulle F. (Gene 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Goliath, a ring-H2 mitochondrial protein, regulated by luteinizing hormone/human chorionic gonadotropin in rat Leydig cells. (PubMed id 13679316)1, 2 Guais A.... Bulle F. (Biol. Reprod. 2004)
    5. Cloning of murine G1RP, a novel gene related to Drosophila melanogaster g1. (PubMed id 10806348)1, 3 Baker S.J. and Reddy E.P. (Gene 2000)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    8. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    9. Proteomic profiling of Myc-associated proteins. (PubMed id 21150319)1 Agrawal P....Sedivy J.M. (Cell Cycle 2010)
    10. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55819 HGNC: 18280 AceView: RNF130 Ensembl:ENSG00000113269 euGenes: HUgn55819
    ECgene: RNF130 H-InvDB: RNF130

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RNF130 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for RNF130 gene:
    Search GeneIP for patents involving RNF130

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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