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Aliases for RNF130 Gene

Aliases for RNF130 Gene

  • Ring Finger Protein 130 2 3
  • Goliath Homolog 3 4
  • E3 Ubiquitin-Protein Ligase RNF130 3
  • G1-Related Zinc Finger Protein 3
  • RING Finger Protein 130 4
  • EC 6.3.2.- 4
  • H-Goliath 4
  • EC 2.1.1 63
  • EC 6.3.2 63
  • G1RZFP 3
  • GP 3

External Ids for RNF130 Gene

Previous GeneCards Identifiers for RNF130 Gene

  • GC05M179446
  • GC05M179492
  • GC05M179315
  • GC05M179382
  • GC05M174107
  • GC05M179345

Summaries for RNF130 Gene

Entrez Gene Summary for RNF130 Gene

  • The protein encoded by this gene contains a RING finger motif and is similar to g1, a Drosophila zinc-finger protein that is expressed in mesoderm and involved in embryonic development. The expression of the mouse counterpart was found to be upregulated in myeloblastic cells following IL3 deprivation, suggesting that this gene may regulate growth factor withdrawal-induced apoptosis of myeloid precursor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for RNF130 Gene

RNF130 (Ring Finger Protein 130) is a Protein Coding gene. Diseases associated with RNF130 include gestational trophoblastic neoplasm and trophoblastic neoplasm. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is RNF167.

UniProtKB/Swiss-Prot for RNF130 Gene

  • May have a role during the programmed cell death of hematopoietic cells (By similarity). Acts as an E3 ubiquitin-protein ligase.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF130 Gene

Genomics for RNF130 Gene

Regulatory Elements for RNF130 Gene

Genomic Location for RNF130 Gene

179,911,651 bp from pter
180,072,130 bp from pter
160,480 bases
Minus strand

Genomic View for RNF130 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNF130 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF130 Gene

Proteins for RNF130 Gene

  • Protein details for RNF130 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    E3 ubiquitin-protein ligase RNF130
    Protein Accession:
    Secondary Accessions:
    • J3KN31
    • Q32P32
    • Q59EL1
    • Q641P9
    • Q6P177
    • Q7L2U2
    • Q9P0J9

    Protein attributes for RNF130 Gene

    419 amino acids
    Molecular mass:
    46405 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAF67007.1; Type=Frameshift; Positions=110, 116; Evidence={ECO:0000305}; Sequence=BAD93037.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for RNF130 Gene


neXtProt entry for RNF130 Gene

Proteomics data for RNF130 Gene at MOPED

Selected DME Specific Peptides for RNF130 Gene

Post-translational modifications for RNF130 Gene

  • In vivo measurements suggest this protein is glycosylated (PubMed:19159218). In contrast, in vitro experiments failed to detect glycosylation (PubMed:16549277).
  • Ubiquitination at Lys310
  • Glycosylation at Asn29, Asn40, Asn112, Asn135, Asn172, and Asn189
  • Modification sites at PhosphoSitePlus

Other Protein References for RNF130 Gene

Domains for RNF130 Gene

Gene Families for RNF130 Gene

  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for RNF130 Gene

Suggested Antigen Peptide Sequences for RNF130 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q86XS8
  • Contains 1 PA (protease associated) domain.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF130: view

Function for RNF130 Gene

Molecular function for RNF130 Gene

UniProtKB/Swiss-Prot Function:
May have a role during the programmed cell death of hematopoietic cells (By similarity). Acts as an E3 ubiquitin-protein ligase.

Enzyme Numbers (IUBMB) for RNF130 Gene

Gene Ontology (GO) - Molecular Function for RNF130 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 16549277
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with RNF130: view

Phenotypes for RNF130 Gene

GenomeRNAi human phenotypes for RNF130:
genes like me logo Genes that share phenotypes with RNF130: view

Animal Model Products

miRNA for RNF130 Gene

miRTarBase miRNAs that target RNF130

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for RNF130 Gene

Localization for RNF130 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF130 Gene

Membrane; Single-pass type I membrane protein. Cytoplasm.

Subcellular locations from

Jensen Localization Image for RNF130 Gene COMPARTMENTS Subcellular localization image for RNF130 gene
Compartment Confidence
nucleus 4
cytosol 3
plasma membrane 3
endoplasmic reticulum 1
extracellular 1

Gene Ontology (GO) - Cellular Components for RNF130 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RNF130: view

Pathways for RNF130 Gene

SuperPathways for RNF130 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q86XS8-GOLI_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for RNF130 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0012501 programmed cell death ISS 13679316
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with RNF130: view

No data available for Pathways by source for RNF130 Gene

Transcripts for RNF130 Gene

Unigene Clusters for RNF130 Gene

Ring finger protein 130:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNF130

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF130 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: - -
SP2: - - - -
SP3: - - -

Relevant External Links for RNF130 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNF130 Gene

mRNA expression in normal human tissues for RNF130 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNF130 Gene

This gene is overexpressed in Whole Blood (5.4).

Protein differential expression in normal tissues for RNF130 Gene

This gene is overexpressed in Adipocyte (64.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RNF130 Gene

SOURCE GeneReport for Unigene cluster for RNF130 Gene Hs.484363

mRNA Expression by UniProt/SwissProt for RNF130 Gene

Tissue specificity: Ubiquitously expressed. Highly expressed in leukocytes. Not expressed in erythroblasts.
genes like me logo Genes that share expressions with RNF130: view

Expression partners for RNF130 Gene

In Situ Assay Products

Orthologs for RNF130 Gene

This gene was present in the common ancestor of animals.

Orthologs for RNF130 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RNF130 35
  • 94.59 (n)
  • 98.57 (a)
RNF130 36
  • 98 (a)
(Canis familiaris)
Mammalia RNF130 35
  • 94.86 (n)
  • 99.11 (a)
RNF130 36
  • 99 (a)
(Mus musculus)
Mammalia Rnf130 35
  • 93.16 (n)
  • 98.09 (a)
Rnf130 16
Rnf130 36
  • 98 (a)
(Pan troglodytes)
Mammalia RNF130 35
  • 99.6 (n)
  • 100 (a)
RNF130 36
  • 100 (a)
(Rattus norvegicus)
Mammalia LOC652955 35
  • 93.32 (n)
  • 98.09 (a)
(Monodelphis domestica)
Mammalia RNF130 36
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia RNF130 36
  • 93 (a)
(Gallus gallus)
Aves RNF130 35
  • 80.5 (n)
  • 83.75 (a)
RNF130 36
  • 80 (a)
(Anolis carolinensis)
Reptilia RNF130 36
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf130 35
  • 71.61 (n)
  • 77.64 (a)
Str.15810 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.33763 35
(Danio rerio)
Actinopterygii wufc14g02 35
zgc:113271 35
  • 66.2 (n)
  • 66.57 (a)
RNF130 (1 of 2) 36
  • 65 (a)
RNF130 (2 of 2) 36
  • 41 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8367 35
(Caenorhabditis elegans)
Secernentea H10E21.5 36
  • 22 (a)
Species with no ortholog for RNF130:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RNF130 Gene

Gene Tree for RNF130 (if available)
Gene Tree for RNF130 (if available)

Paralogs for RNF130 Gene

Selected SIMAP similar genes for RNF130 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with RNF130: view

Variants for RNF130 Gene

Sequence variations from dbSNP and Humsavar for RNF130 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs3719 -- 180,008,118(+) TAGAT(C/T)CCTGA intron-variant
rs9202 -- 179,970,434(+) AATAT(A/T)TTAAG missense, reference
rs10169 -- 179,955,543(+) AAAAA(A/T)AAAAT utr-variant-3-prime
rs14755 -- 179,955,597(+) CACAA(A/T)AATAG utr-variant-3-prime
rs26073 -- 179,974,287(+) CCACG(C/T)GGCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNF130 Gene

Variant ID Type Subtype PubMed ID
nsv830561 CNV Loss 17160897
esv2674593 CNV Deletion 23128226
esv2731313 CNV Deletion 23290073
esv2731314 CNV Deletion 23290073
esv2731315 CNV Deletion 23290073

Relevant External Links for RNF130 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF130 Gene

Disorders for RNF130 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for RNF130 Gene in MalaCards »

(2) Diseases for RNF130 Gene including...

(1) University of Copenhagen DISEASES for RNF130 Gene

Relevant External Links for RNF130

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with RNF130: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for RNF130 Gene

Publications for RNF130 Gene

  1. Goliath, a ring-H2 mitochondrial protein, regulated by luteinizing hormone/human chorionic gonadotropin in rat Leydig cells. (PMID: 13679316) Guais A. … Bulle F. (Biol. Reprod. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. h-Goliath, paralog of GRAIL, is a new E3 ligase protein, expressed in human leukocytes. (PMID: 16549277) Guais A. … Bulle F. (Gene 2006) 3 4
  4. Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. (PMID: 21347282) Lettre G. … Boerwinkle E. (PLoS Genet. 2011) 3 48
  5. Cloning of murine G1RP, a novel gene related to Drosophila melanogaster g1. (PMID: 10806348) Baker S.J. … Reddy E.P. (Gene 2000) 2 3

Products for RNF130 Gene

Sources for RNF130 Gene

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