RNF130 Gene
protein-coding GIFtS: 48
GCID: GC05M179345
|
|
ring finger protein 130
| |
Aliases
for RNF130 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ring Finger Protein 1301 2 3 | | E3 Ubiquitin-Protein Ligase RNF1302 | | G1RZFP1 2 | | G1-Related Zinc Finger Protein2 | | GOLIATH1 2 | | EC 6.3.2.-3 | | GP1 2 | | EC 2.1.18 | | Goliath Homolog2 3 | | EC 6.3.28 | | H-Goliath2 3 | | |
Export aliases for RNF130 gene to outside databasesPrevious GC identifers: GC05M179446 GC05M179492 GC05M179315 GC05M179382 GC05M174107 |
Summaries
for RNF130 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RNF130:
The protein encoded by this gene contains a RING finger motif and is similar to g1, a Drosophila zinc-finger proteinthat is expressed in mesoderm and involved in embryonic development. The expression of the mouse counterpart was foundto be upregulated in myeloblastic cells following IL3 deprivation, suggesting that this gene may regulate growthfactor withdrawal-induced apoptosis of myeloid precursor cells. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: GOLI_HUMAN, Q86XS8Function: May have a role during the programmed cell death of hematopoietic cells (By similarity). Acts as an E3ubiquitin-protein ligase
|
Genomic Views
for RNF130 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_023133.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RNF130 gene promoter:
c-Fos AP-1 ATF-2 CUTL1 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for RNF130
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF130 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q35.3 Ensembl cytogenetic band: 5q35.3 HGNC cytogenetic band: 5q35.3RNF130 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M179345: view genomic region
(about GC identifiers)
Start:
|
179,345,911 bp from pter |
End:
|
179,499,118 bp from pter |
Size:
|
153,208 bases |
Orientation:
|
minus strand |
|
Proteins
for RNF130 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: GOLI_HUMAN, Q86XS8 (See
protein sequence)Recommended Name: E3 ubiquitin-protein ligase RNF130 precursor Size: 419 amino acids; 46405 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential). Cytoplasm
Sequence caution: Sequence=AAF67007.1; Type=Frameshift; Positions=110, 116;
Secondary accessions: Q32P32 Q641P9 Q6P177 Q7L2U2 Q9P0J9Explore the universe of human proteins at neXtProt for RNF130: NX_Q86XS8
Post-translational modifications:
In vivo measurements suggest this protein is glycosylated (PubMed:19159218). In contrast, in vitro experiments failedto detect glycosylation (PubMed:16549277)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86XS8
2 DME Specific Peptides for RNF130 (Q86XS8)
RNF130 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060904.2
ENSEMBL proteins: ENSP00000429509 ENSP00000430237 ENSP00000261947 ENSP00000430999 ENSP00000429242
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
RNF130 for ontologies About GeneDecksing
RNF130 Antibody Products:
Assay Products for RNF130: |
Protein
Domains /
Families
for RNF130 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RNF130 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q86XS8ProtoNet protein and cluster: Q86XS8 2 Blocks protein families: IPB001841 Zn-finger IPB003137 Protease-associated PA
UniProtKB/Swiss-Prot: GOLI_HUMAN, Q86XS8Similarity: Contains 1 PA (protease associated) domainSimilarity: Contains 1 RING-type zinc finger |
Function
for RNF130 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: GOLI_HUMAN, Q86XS8Function: May have a role during the programmed cell death of hematopoietic cells (By similarity). Acts as an E3ubiquitin-protein ligaseEnzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22 EC 2.1.12
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF130
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF130 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
RNF130 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for RNF130:
|
Pathways & Interactions
for RNF130 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
UniProtKB/Swiss-Prot: GOLI_HUMAN, Q86XS8Pathway: Protein modification; protein ubiquitinationInteractions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RNF130
STRING Interaction
Network Preview (showing 5 interactants - click image to see 12)
5/544 Interacting proteins for RNF130 (Q86XS82, 3 ENSP000002619474) via UniProtKB, MINT, STRING, and/or I2D (see all 544) About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
RNF130 for ontologies About GeneDecksing
|
Drugs & Compounds
for RNF130 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RNF130
Search CenterWatch for drugs/clinical trials and news about RNF130 / GOLI
|
Transcripts
for RNF130 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RNF130 gene: NM_018434.4 Unigene Cluster for RNF130: Ring finger protein 130 Hs.484363 [show with all ESTs]Unigene Representative Sequence: AL8318739 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000522208 ENST00000521389(uc003mll.1 uc003mlm.1) ENST00000261947
ENST00000520564 ENST00000521901 ENST00000520911 ENST00000522885 ENST00000519708
ENST00000523487
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF130 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF130
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Additional cDNA sequence: AB209800.1 AF155650.1 AK313089.1 AL831873.1 AY083998.1 BC017100.1 BC065244.1 BC082267.1 BC108306.1 BC113864.1 BC114472.1 16 DOTS entries: DT.446422 DT.99982777 DT.100824260 DT.120830785 DT.75100535 DT.120830787 DT.100726855 DT.120830770 DT.91797153 DT.100824264 DT.120830764 DT.120830809 DT.91926559 DT.100824262 DT.121630433 DT.40248353 24/446 AceView cDNA sequences (see all 446): AI567085 AI200736 BG055457 AW024979 AI769946 AW131613 CA944924 AI583987 CB241498 BM709172 AA430360 BQ774793 CA422830 BM723499 D79226 BM021495 AW299944 BU608590 BE048710 AW612601 AY083998 AI719360 BX333053 BU628921
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for RNF130 About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 |
|---|
|
| SP1: | | | | | | | | | | | - | | | | | | | | | | | | - | | | | |
| SP2: | | | | | - | | - | | | | - | | | | | | | | | | | | - | | | | |
| SP3: | | | | | | | | | | | - | | | | | | | | | | - | | - | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for RNF130
|
Expression
for RNF130 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RNF130 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCACACAAGC
About this image
See RNF130 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RNF130
SOURCE GeneReport for Unigene cluster: Hs.484363
UniProtKB/Swiss-Prot: GOLI_HUMAN, Q86XS8Tissue specificity: Ubiquitously expressed. Highly expressed in leukocytes. Not expressed in erythroblasts
SABiosciences Expression via Pathway-Focused PCR Array including RNF130:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNF130
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF130 |
Orthologs
for RNF130 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for RNF130 gene from 7/20 species (see all 20) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Rnf1301 , 5 |
ring finger protein 1301, 5 |
93.16(n)1
98.09(a)1 |
|
11 (30.16 cM)5
590441 NM_021540.31 NP_067515.21
500253465 |
chicken
(Gallus gallus) |
Aves |
RNF1301 |
ring finger protein 130 |
79.07(n)
81.88(a) |
|
416281 XM_414601.3 XP_414601.3 |
lizard
(Anolis carolinensis) |
Reptilia |
RNF1306 |
-- |
80(a) |
1 ↔ 1 |
2(139983859-140046307) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.337632 |
Xenopus laevis transcribed sequence with weak similarity more |
78.2(n) |
|
BJ088082.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufc14g022 |
wufc14g02 |
77.9(n) |
|
323940 57053425 |
fruit fly
(Drosophila melanogaster) |
Insecta |
gol6 |
goliath |
22(a) |
1 → many |
2R(20960150-20971843) |
worm
(Caenorhabditis elegans) |
Secernentea |
H10E21.56 |
Protein H10E21.5 |
20(a) |
1 → many |
III(20527-23962) |
ENSEMBL Gene Tree for RNF130 (if available)
TreeFam Gene Tree for RNF130 (if available) |
Paralogs
for RNF130 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RNF130 gene
- ZNRF32 RNF432 RNF1482 RNF1492 RNF1332 RNF1672 RNF1502 RNF2152
- RNF1282 ZNRF42 RNF132
7 SIMAP similar genes for RNF130 using alignment to 6 protein entries: GOLI_HUMAN (see all proteins):RNF150 RNF128 RNF149 RNF13 RNF133 RNF148
LOC284996
RNF130 for paralogs About GeneDecksing
|
Genomic Variants
for RNF130 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RNF130 (179345911 - 179499118 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RNF130: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNF130 |
|
Disorders
/ Diseases
for RNF130 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RNF130 for disorders About GeneDecksing
5  diseases for RNF130: About MalaCardsgestational trophoblastic neoplasm trophoblastic neoplasm progeria hyperinsulinism
hyperglycemia
1 disease from the University of Copenhagen DISEASES database for RNF130:Gestational trophoblastic neoplasm Export disorders for RNF130 gene to outside databases
|
Publications
for RNF130 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RNF130 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with RNF130) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- h-Goliath, paralog of GRAIL, is a new E3 ligase protein, expressed in human leukocytes. (PubMed id 16549277)1, 2 Guais A....Bulle F. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Goliath, a ring-H2 mitochondrial protein, regulated by luteinizing hormone/human chorionic gonadotropin in rat Leydig cells. (PubMed id 13679316)1, 2 Guais A.... Bulle F. (2004)
- Cloning of murine G1RP, a novel gene related to Drosophila melanogaster g1. (PubMed id 10806348)1, 3 Baker S.J. and Reddy E.P. (2000)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Genome-wide association study of coronary heart disea se and its risk factors in 8,090 African Americans: the NHLBI CARe Project. (PubMed id 21347282)1 Lettre G....Boerwinkle E. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. (PubMed id 19690564)1 van Wijk S.J....Timmers H.T. (2009)
- Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)2 Chen R.... Zou H. (2009)
|
External Searches for RNF130 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RNF130 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RNF130 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RNF130 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RNF130 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RNF130 gene:
Search GeneIP for patents involving RNF130
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RNF130 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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| |  |  |  |  | | | | |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF130 |
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