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RNF128 Gene

protein-coding   GIFtS: 59
GCID: GC0XP105937

Ring Finger Protein 128, E3 Ubiquitin Protein Ligase

(Previous name: ring finger protein 128)
  Search for RNF128
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ring Finger Protein 128, E3 Ubiquitin Protein Ligase1 2     E3 Ubiquitin-Protein Ligase RNF1282
GRAIL2 3 5     EC 6.3.2.-3
RING Finger Protein 1281 3     EC 6.3.28
Gene Related To Anergy In Lymphocytes Protein2 3     

External Ids:    HGNC: 211531   Entrez Gene: 795892   Ensembl: ENSG000001331357   OMIM: 3004395   UniProtKB: Q8TEB73   

Export aliases for RNF128 gene to outside databases

Previous GC identifers: GC0XP103969 GC0XP104708 GC0XP105743 GC0XP105823 GC0XP095565


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RNF128 Gene:
The protein encoded by this gene is a type I transmembrane protein that localizes to the endocytic pathway. This
protein contains a RING zinc-finger motif and has been shown to possess E3 ubiquitin ligase activity. Expression
of this gene in retrovirally transduced T cell hybridoma significantly inhibits activation-induced IL2 and IL4
cytokine production. Induced expression of this gene was observed in anergic CD4(+) T cells, which suggested a
role in the induction of anergic phenotype. Alternatively spliced transcript variants encoding distinct isoforms
have been reported. (provided by RefSeq, Jul 2008)

GeneCards Summary for RNF128 Gene:
RNF128 (ring finger protein 128, E3 ubiquitin protein ligase) is a protein-coding gene. GO annotations related to this gene include ubiquitin-protein ligase activity. An important paralog of this gene is ZNRF3.

UniProtKB/Swiss-Prot: RN128_HUMAN, Q8TEB7
Function: E3 ubiquitin-protein ligase that catalyzes 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains formation.
Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription, thereby playing an
important role in the induction of the anergic phenotype, a long-term stable state of T-lymphocyte
unresponsiveness to antigenic stimulation associated with the blockade of interleukin production. Ubiquitinates
ARPC5 with 'Lys-48' linkages and COR1A with 'Lys-63' linkages leading to their degradation, down-regulation of
these cytosleletal components results in impaired lamellipodium formation and reduced accumulation of F-actin at
the immunological synapse. Functions in the patterning of the dorsal ectoderm; sensitizes ectoderm to respond to
neural-inducing signals

Gene Wiki entry for RNF128 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NC_018934.2  NT_011651.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the RNF128 gene promoter:
         Bach1   HOXA9   HOXA9B   STAT1   USF1   LCR-F1   Meis-1b   USF-1   Zic3   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RNF128 promoter sequence
   Search Chromatin IP Primers for RNF128

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNF128


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq22.3   Ensembl cytogenetic band:  Xq22.3   HGNC cytogenetic band: Xq22.3

RNF128 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF128 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP105937:  view genomic region     (about GC identifiers)

Start:
105,937,024 bp from pter      End:
106,040,246 bp from pter
Size:
103,223 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RN128_HUMAN, Q8TEB7 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase RNF128 precursor  
Size: 428 amino acids; 46521 Da
Sequence caution: Sequence=BAB15682.1; Type=Frameshift; Positions=291;
1 PDB 3D structure from and Proteopedia for RNF128:
3ICU (3D)    
Secondary accessions: A0PJI4 Q6PH80 Q6ZTJ8 Q96RF3 Q9H5E4
Alternative splicing: 2 isoforms:  Q8TEB7-1   Q8TEB7-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RNF128: NX_Q8TEB7

Explore proteomics data for RNF128 at MOPED

Post-translational modifications: 

  • Auto-ubiquitinated. Controls the development of T-cell clonal anergy by ubiquitination1
  • Glycosylation2 at Asn48, Asn59, Asn101
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for RNF128 (Q8TEB7) (see all 9)
     VRILTCNH  QVTMVIEVG  VAIMIGNLKG  ALIQRGGGCTF 


    See RNF128 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_078815.3  NP_919445.1  

    ENSEMBL proteins: 
     ENSP00000412610   ENSP00000316127   ENSP00000255499  

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    Search eBioscience for ELISAs for RNF128 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers

    3 InterPro protein domains:
     IPR001841 Znf_RING
     IPR003137 Protease-assoc_domain
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q8TEB7

    ProtoNet protein and cluster: Q8TEB7

    2 Blocks protein domains:
    IPB001841 Zn-finger
    IPB003137 Protease-associated PA


    UniProtKB/Swiss-Prot: RN128_HUMAN, Q8TEB7
    Domain: Binding to E2 ubiquitin-conjugating enzyme requires an intact RING finger domain
    Similarity: Contains 1 PA (protease associated) domain
    Similarity: Contains 1 RING-type zinc finger


    Find genes that share domains with RNF128           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RN128_HUMAN, Q8TEB7
    Function: E3 ubiquitin-protein ligase that catalyzes 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains formation.
    Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription, thereby playing an
    important role in the induction of the anergic phenotype, a long-term stable state of T-lymphocyte
    unresponsiveness to antigenic stimulation associated with the blockade of interleukin production. Ubiquitinates
    ARPC5 with 'Lys-48' linkages and COR1A with 'Lys-63' linkages leading to their degradation, down-regulation of
    these cytosleletal components results in impaired lamellipodium formation and reduced accumulation of F-actin at
    the immunological synapse. Functions in the patterning of the dorsal ectoderm; sensitizes ectoderm to respond to
    neural-inducing signals
    Induction: Induced under anergic conditions. Up-regulated during T-cell anergy induction following signaling
    through the T-cell antigen receptor

         Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IEA--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0046872metal ion binding ----
         
    Find genes that share ontologies with RNF128           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for RNF128:
     Synthetic lethal with Ras 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Rnf128):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  nervous system 
     respiratory system 

    Find genes that share phenotypes with RNF128           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for RNF128: Rnf128tm1.1Flv Rnf128tm1Cdon

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RNF128
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RNF128
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RNF128

    miRNA
    Products:
        
    miRTarBase miRNAs that target RNF128:
    hsa-mir-132-3p (MIRT021799), hsa-mir-7-5p (MIRT025823), hsa-mir-92a-3p (MIRT048992)

    Block miRNA regulation of human, mouse, rat RNF128 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RNF128 (see all 19):
    hsa-miR-142-5p hsa-miR-4311 hsa-miR-607 hsa-miR-539 hsa-miR-106a hsa-miR-519a hsa-miR-124 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidRNF128 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RNF128

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    Sino Biological Human cDNA Clone for RNF128
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF128
    Addgene plasmids for RNF128 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF128


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RN128_HUMAN, Q8TEB7: Endomembrane system; Single-pass membrane protein (By similarity). Cytoplasm, cytoskeleton.
    Cytoplasm, perinuclear region (By similarity). Note=Localized in an asymmetric perinuclear punctate manner.
    Localizes to the internal pool of the transferrin recycling endosomal pathway. Partially colocalized with the
    endoplasmic reticulum resident HSPA5, with Golgi resident STX5, and with the late endosomal GTPase RAB7A (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum2
    endosome2
    extracellular2
    golgi apparatus2
    plasma membrane2
    cytosol1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005770late endosome IEA--
    GO:0005783endoplasmic reticulum IEA--
    GO:0005794Golgi apparatus IEA--
    GO:0005856cytoskeleton IEA--
    GO:0012505endomembrane system ----

    Find genes that share ontologies with RNF128           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RNF128 About    
    See pathways by source

    SuperPathContained pathways About
    1Calcineurin-regulated NFAT-dependent transcription in lymphocytes
    Calcineurin-regulated NFAT-dependent transcription in lymphocytes0.38


    1 BioSystems Pathway for RNF128
        Calcineurin-regulated NFAT-dependent transcription in lymphocytes



    UniProtKB/Swiss-Prot: RN128_HUMAN, Q8TEB7
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Arrays including RNF128: 

              T-Cell Anergy & Immune Tolerance in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for RNF128

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for RNF128 (Q8TEB73 ENSP000002554994) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD151P485093, ENSP000003241014I2D: score=2 STRING: ENSP00000324101
    CD40LGP299653, ENSP000003596634I2D: score=2 STRING: ENSP00000359663
    UBE2IP632793, ENSP000003248974I2D: score=2 STRING: ENSP00000324897
    UBE2NP610883, ENSP000003161764I2D: score=2 STRING: ENSP00000316176
    USP8P408183, ENSP000003022394I2D: score=1 STRING: ENSP00000302239
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0042036negative regulation of cytokine biosynthetic process IEA--

    Find genes that share ontologies with RNF128           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RNF128 (RN128)

    4 HMDB Compounds for RNF128    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RNF128 gene (2 alternative transcripts): 
    NM_024539.3  NM_194463.1  

    Unigene Cluster for RNF128:

    Ring finger protein 128, E3 ubiquitin protein ligase
    Hs.496542  [show with all ESTs]
    Unigene Representative Sequence: NM_194463
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000418562 ENST00000324342(uc004emk.3) ENST00000255499(uc004eml.3)

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate RNF128 (see all 19):
    hsa-miR-142-5p hsa-miR-4311 hsa-miR-607 hsa-miR-539 hsa-miR-106a hsa-miR-519a hsa-miR-124 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidRNF128 3' UTR sequence
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    Addgene plasmids for RNF128 
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      QuantiTect SYBR Green Assays in human, mouse, rat RNF128
      QuantiFast Probe-based Assays in human, mouse, rat RNF128

    Additional mRNA sequence: 

    AF394689.1 AK027169.1 AK074264.1 AK126553.1 BC012931.1 BC030951.1 BC036901.1 BC056677.1 
    BC063404.1 

    2 DOTS entries:

    DT.40237109  DT.97768736 

    Selected AceView cDNA sequences (see all 124):

    BE536963 AA554040 BF593954 NM_024539 BC056677 AK074264 BM460110 BI964160 
    AK126553 BC063404 AI682800 AV692456 BU173514 BI792320 AI580191 BM506687 
    BG165006 BC012931 BI963863 BI715115 AA595575 AW613123 NM_194463 CD107148 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for RNF128    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
    SP1:                                                                        
    SP2:                    -                                                   
    SP3:                    -                                                   
    SP4:                                                                        


    ECgene alternative splicing isoforms for RNF128

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RNF128 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    RNF128 Expression
    About this image


    RNF128 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Kidney (Urinary System)    fully expand to see all 5 entries
             Ureteric Bud Cells Ureteric Bud
             Metanephros
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Epithelial Cells
             Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Lower Urinary Tract (Urinary System)
             Ureter
    RNF128 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RNF128 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.496542
        Pathway & Disease-focused RT2 Profiler PCR Arrays including RNF128: 
              T-Cell Anergy & Immune Tolerance in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for RNF128
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    QuantiFast Probe-based Assays in human, mouse, rat RNF128
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF128

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RNF128 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnf1281 , 5 ring finger protein 1281, 5 91.51(n)1
    95.33(a)1
      X (61.35 cM)5
    668891  NM_023270.51  NP_075759.31 
     1395633165 
    chicken
    (Gallus gallus)
    Aves RNF1281 ring finger protein 128 71.97(n)
    69.44(a)
      422382  XM_420351.4  XP_420351.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    56(a)
    1 → many
    GL343842.1(8227-32438)
    African clawed frog
    (Xenopus laevis)
    Amphibia rnf128-A2 ring finger protein 128/E3 ubiquitin ligase 75.69(n)    AY112655.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb57h052 Transcribed sequence with weak similarity to protein more 76.22(n)    CA471513.1 
    worm
    (Caenorhabditis elegans)
    Secernentea H10E21.56
    Protein H10E21.5 (H10E21.5) mRNA, complete cds
    18(a)
    1 → many
    III(20527-23962) WBGene00019185


    ENSEMBL Gene Tree for RNF128 (if available)
    TreeFam Gene Tree for RNF128 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RNF128 gene
    ZNRF32  RNF432  RNF1482  RNF1492  RNF1332  RNF1502  RNF1302  RNF1672  
    RNF2152  ZNRF42  RNF132  
    5 SIMAP similar genes for RNF128 using alignment to 2 protein entries:     RN128_HUMAN (see all proteins):
    RNF133    RNF148    RNF130    RNF150    RNF149

    Find genes that share paralogs with RNF128           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RNF128 (see all 1263)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs78852821,2
    C,F,H--105906993(+) GTAACT/ATCTCA 1 -- us2k15Minor allele frequency- A:0.02NS EA WA 420
    rs1861239641,2
    --105907185(+) AATAAC/TAATAA 1 -- us2k10--------
    rs1894112781,2
    --105907247(+) TTGTGA/GTCCTA 1 -- us2k10--------
    rs59623561,2
    C,F,A,H--105907288(+) AAAATA/CATGAA 1 -- us2k1 tfbs313Minor allele frequency- C:0.26NS EA NA CSA 1331
    rs1808143691,2
    --105907319(+) ATTGAC/TCATAA 1 -- us2k10--------
    rs1511298951,2
    --105907364(+) ATTATA/GTGAAT 1 -- us2k10--------
    rs78847401,2
    C--105907408(+) GTACCA/CGGTAC 1 -- us2k10--------
    rs1468468071,2
    --105907426(+) GGGTAC/TGCTAA 1 -- us2k10--------
    rs1860942281,2
    --105907454(+) TGATAC/TGATAG 1 -- us2k10--------
    rs1392640711,2
    C--105907613(+) AAAGCA/GGACAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RNF128 (105937024 - 106040246 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for RNF128:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2667443CNV Deletion23128226
    nsv510852CNV Loss20534489
    esv2752312CNV Gain17911159

    Human Gene Mutation Database (HGMD): RNF128
    Locus Specific Mutation Databases (LSDB): RNF128

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RNF128
    DNA2.0 Custom Variant and Variant Library Synthesis for RNF128

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300439    OMIM disorders: --


    Find genes that share disorders with RNF128           About GenesLikeMe


    Export disorders for RNF128 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RNF128 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with RNF128)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. GRAIL: an E3 ubiquitin ligase that inhibits cytokine gene transcription is expressed in anergic CD4+ T cells. (PubMed id 12705856)1, 2, 9 Anandasabapathy N.... Soares L. (Immunity 2003)
    2. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Grail as a molecular determinant for the functions of the tumor suppressor p53 in tumorigenesis. (PubMed id 23370271)1 Chen Y.C....Huang S.M. (Cell Death Differ. 2013)
    6. GRAIL (gene related to anergy in lymphocytes) regulates cytoskeletal reorganization through ubiquitination and degradation of Arp2/3 subunit 5 and coronin 1A. (PubMed id 22016387)2 Ichikawa D.... Miyake S. (J. Biol. Chem. 2011)
    7. Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. (PubMed id 19549727)1 Markson G....Sanderson C.M. (Genome Res. 2009)
    8. The transmembrane E3 ligase GRAIL ubiquitinates and degrades CD83 on CD4 T cells. (PubMed id 19542455)1 Su L.L....Fathman C.G. (J. Immunol. 2009)
    9. Naive CD4 t cell proliferation is controlled by mammalian target of rapamycin regulation of GRAIL expression. (PubMed id 19414743)1 Lin J.T....Wu L. (J. Immunol. 2009)
    10. Cutting edge: The transmembrane E3 ligase GRAIL ubiquitinates the costimulatory molecule CD40 ligand during the induction of T cell anergy. (PubMed id 18641297)1 Lineberry N.B....Fathman C.G. (J. Immunol. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79589 HGNC: 21153 AceView: RNF128 Ensembl:ENSG00000133135 euGenes: HUgn79589
    ECgene: RNF128 H-InvDB: RNF128

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RNF128 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RNF128 gene:
    Search GeneIP for patents involving RNF128

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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