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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RNF128 Gene

protein-coding GIFtS: 57
GCID: GC0XP105937

ring finger protein 128, E3 ubiquitin protein ligase

(Previous name: ring finger protein 128 )

Explore 3 diseases affiliated with
RNF128 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ring Finger Protein 128, E3 Ubiquitin Protein Ligase¹ ²		FLJ23516¹
GRAIL¹ ² ³ ⁵		E3 Ubiquitin-Protein Ligase RNF128²
RING Finger Protein 128¹ ³		EC 6.3.2.-³
Gene Related To Anergy In Lymphocytes Protein² ³		EC 6.3.2⁸

External Ids:	HGNC: 21153¹	Entrez Gene: 79589²	Ensembl: ENSG00000133135⁷	OMIM: 300439⁵	UniProtKB: Q8TEB7³

Export aliases for RNF128 gene to outside databases

Previous GC identifers: GC0XP103969 GC0XP104708 GC0XP105743 GC0XP105823 GC0XP095565

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RNF128:

The protein encoded by this gene is a type I transmembrane protein that localizes to the endocytic pathway. This

protein contains a RING zinc-finger motif and has been shown to possess E3 ubiquitin ligase activity. Expression of

this gene in retrovirally transduced T cell hybridoma significantly inhibits activation-induced IL2 and IL4 cytokine

production. Induced expression of this gene was observed in anergic CD4(+) T cells, which suggested a role in the

induction of anergic phenotype. Alternatively spliced transcript variants encoding distinct isoforms have been

reported. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: RN128_HUMAN, Q8TEB7

Function: E3 ubiquitin-protein ligase that catalyzes polyubiquitin chains. Functions as an inhibitor of cytokine gene

transcription. Inhibits IL2 and IL4 transcription and this activity is likely to be mediated by E3 ligase activity.

Plays an important role in the induction of the anergic phenotype. Functions in the patterning of the dorsal ectoderm;

sensitizes ectoderm to respond to neural-inducing signals (By similarity)

Gene Wiki entry for RNF128

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000023.10 NC_018934.1 NT_011651.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RNF128 gene promoter:
Bach1 HOXA9 HOXA9B STAT1 USF1 LCR-F1 Meis-1b USF-1 Zic3 Meis-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RNF128 promoter sequence

Search SABiosciences Chromatin IP Primers for RNF128

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF128

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq22.3 Ensembl cytogenetic band: Xq22.3 HGNC cytogenetic band: Xq22.3

RNF128 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF128 gene location

GeneLoc information about chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XP105937: view genomic region (about GC identifiers)

Start:	105,937,024 bp from pter	End:	106,040,246 bp from pter
Size:	103,223 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RN128_HUMAN, Q8TEB7 (See protein sequence)

Recommended Name: E3 ubiquitin-protein ligase RNF128 precursor

Size: 428 amino acids; 46521 Da

Subcellular location: Endomembrane system; Single-pass membrane protein (By similarity). Cytoplasm, perinuclear region

(By similarity). Note=Localized in an asymmetric perinuclear punctate manner. Localizes to the internal pool of the

transferrin recycling endosomal pathway. Partially colocalized with the endoplasmic reticulum resident HSPA5, with

Golgi resident STX5, and with the late endosomal GTPase RAB7A (By similarity)

Sequence caution: Sequence=BAB15682.1; Type=Frameshift; Positions=291;

1 PDB 3D structure from and Proteopedia for RNF128:

3ICU (3D)

Secondary accessions: Q6PH80 Q6ZTJ8 Q96RF3 Q9H5E4

Alternative splicing: 2 isoforms: Q8TEB7-1 Q8TEB7-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RNF128: NX_Q8TEB7

Post-translational modifications:

Auto-ubiquitinated. Controls the development of T-cell clonal anergy by ubiquitination¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8TEB7

4/9 DME Specific Peptides for RNF128 (Q8TEB7) (see all 9)

VRILTCNH

QVTMVIEVG

VAIMIGNLKG

ALIQRGGGCTF

RNF128 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_078815.3 NP_919445.1

ENSEMBL proteins:

ENSP00000412610 ENSP00000316127 ENSP00000255499

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	Uscn Proteins for RNF128

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005770	late endosome	IEA	--
GO:0005783	endoplasmic reticulum	IEA	--
GO:0005794	Golgi apparatus	IEA	--
GO:0012505	endomembrane system	IEA	--
GO:0016021	integral to membrane	IEA	--

RNF128 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RNF128 for domains About GeneDecksing

3 InterPro domains/families:

IPR001841 Znf_RING

IPR003137 Protease-assoc_domain

IPR013083 Znf_RING/FYVE/PHD

Graphical View of Domain Structure for InterPro Entry Q8TEB7

ProtoNet protein and cluster: Q8TEB7

2 Blocks protein families:

IPB001841 Zn-finger

IPB003137 Protease-associated PA

UniProtKB/Swiss-Prot: RN128_HUMAN, Q8TEB7

Domain: Binding to E2 ubiquitin-conjugating enzyme requires an intact RING finger domain

Similarity: Contains 1 PA (protease associated) domain

Similarity: Contains 1 RING-type zinc finger

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: RN128_HUMAN, Q8TEB7

Function: E3 ubiquitin-protein ligase that catalyzes polyubiquitin chains. Functions as an inhibitor of cytokine gene

transcription. Inhibits IL2 and IL4 transcription and this activity is likely to be mediated by E3 ligase activity.

Plays an important role in the induction of the anergic phenotype. Functions in the patterning of the dorsal ectoderm;

sensitizes ectoderm to respond to neural-inducing signals (By similarity)

Induction: Induced under anergic conditions. Up-regulated during T-cell anergy induction following signaling through

the T-cell antigen receptor

Enzyme Numbers (IUBMB): EC 6.3.2.-¹ EC 6.3.2²

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In Situ Assay
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Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004842	ubiquitin-protein ligase activity	IEA	--
GO:0008270	zinc ion binding	IEA	--

RNF128 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for RNF128:

Synthetic lethal with Ras

Animal Models:
Mouse knock-outs for RNF128: Rnf128^tm1.1Flv Rnf128^tm1Cdon
6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Rnf128):

cellular	hematopoietic system	homeostasis/metabolism	immune system	nervous system
respiratory system

RNF128 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Calcium signaling in the CD4+ TCR pathway

Calcineurin-regulated NFAT-dependent transcription in lymphocytes

0.38

1 BioSystems Pathway for RNF128

Calcineurin-regulated NFAT-dependent transcription in lymphocytes

UniProtKB/Swiss-Prot: RN128_HUMAN, Q8TEB7

Pathway: Protein modification; protein ubiquitination

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for RNF128

STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

5/11 Interacting proteins for RNF128 (Q8TEB7³ ENSP00000255499⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 11)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CD151	P48509³, ENSP00000324101⁴	I2D: score=2 STRING: ENSP00000324101
CD40LG	P29965³, ENSP00000359663⁴	I2D: score=2 STRING: ENSP00000359663
UBE2I	P63279³, ENSP00000324897⁴	I2D: score=2 STRING: ENSP00000324897
UBE2N	P61088³, ENSP00000316176⁴	I2D: score=2 STRING: ENSP00000316176
USP8	P40818³, ENSP00000302239⁴	I2D: score=1 STRING: ENSP00000302239

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016567	protein ubiquitination	--	--
GO:0042036	negative regulation of cytokine biosynthetic process	IEA	--

RNF128 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RNF128

4 HMDB Compounds for RNF128 About this table

Compound	Synonyms	CAS #	PubMed Ids
Adenosine monophosphate	5'-AMP (see all 28)	61-19-8	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--
Phosphoric acid	acide phosphorique (FRENCH) (see all 20)	7664-38-2	--
Pyrophosphate	(4-)Diphosphoric acid ion (see all 10)	14000-31-8	--

Search CenterWatch for drugs/clinical trials and news about RNF128 / RN128

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RNF128 gene (2 alternative transcripts):

NM_024539.3 NM_194463.1

Unigene Cluster for RNF128:

Ring finger protein 128, E3 ubiquitin protein ligase

Hs.496542 [show with all ESTs]

Unigene Representative Sequence: NM_194463

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000418562 ENST00000324342(uc004emk.3) ENST00000255499(uc004eml.3)

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		hsa-miR-142-5p hsa-miR-4311 hsa-miR-607 hsa-miR-539 hsa-miR-106a hsa-miR-519a hsa-miR-124 hsa-miR-9

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Additional cDNA sequence:

AF394689.1 AK027169.1 AK074264.1 AK126553.1 BC012931.1 BC030951.1 BC036901.1 BC056677.1

BC063404.1

2 DOTS entries:

DT.40237109 DT.97768736

24/124 AceView cDNA sequences (see all 124):

AI682800 CD107148 AK126553 BI792320 BI964160 BU173514 BC056677 NM_194463

AV692456 BF593954 BC063404 BE536963 BI963863 AW613123 BC012931 BM506687

BG165006 AA595575 BI715115 BM460110 AI580191 NM_024539 AK074264 AA554040

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for RNF128 About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	·	4c	^	5	^	6	^	7	^	8	^	9
SP1:
SP2:							-
SP3:							-
SP4:

ECgene alternative splicing isoforms for RNF128

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RNF128 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

RNF128 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Renal Collecting Duct System

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See RNF128 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RNF128

SOURCE GeneReport for Unigene cluster: Hs.496542

SABiosciences Expression via Pathway-Focused PCR Arrays including RNF128:

T-Cell Anergy & Immune Tolerance in human mouse rat

Ubiquitin Ligases in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for RNF128 gene from 6/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	RNF128¹	ring finger protein 128	71.97(n) 69.44(a)		422382 XM_420351.3 XP_420351.1
lizard (Anolis carolinensis)	Reptilia	RNF128⁶	--	64(a)	1 ↔ 1	GL343842.1(8449-29782)
African clawed frog (Xenopus laevis)	Amphibia	rnf128-A²	ring finger protein 128/E3 ubiquitin ligase	75.69(n)		AY112655.1
zebrafish (Danio rerio)	Actinopterygii	wufb57h05²	Transcribed sequence with weak similarity to protein more	76.22(n)		CA471513.1
fruit fly (Drosophila melanogaster)	Insecta	gol⁶	goliath	18(a)	1 → many	2R(20960150-20971843)
worm (Caenorhabditis elegans)	Secernentea	H10E21.5⁶	Protein H10E21.5	17(a)	1 → many	III(20527-23962)

ENSEMBL Gene Tree for RNF128 (if available)
TreeFam Gene Tree for RNF128 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RNF128 gene

ZNRF3² RNF150² RNF130² RNF167² RNF43² RNF148² RNF215² RNF149²

ZNRF4² RNF13² RNF133²

6 SIMAP similar genes for RNF128 using alignment to 3 protein entries: RN128_HUMAN (see all proteins):

RNF148 RNF133 RNF130 LOC284996 RNF150 RNF149

RNF128 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr X pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs7885282^1,2	C,F,H,	--	105935266(+)	`GTAACT/ATCTCA`	1	--	us2k¹		5		NS EA WA	420
rs186123964^1,2		--	105935458(+)	`AATAAC/TAATAA`	1	--	us2k¹		0	--	--	--	--
rs189411278^1,2		--	105935520(+)	`TTGTGA/GTCCTA`	1	--	us2k¹		0	--	--	--	--
rs5962356^1,2	C,F,A,H,	--	105935561(+)	`AAAATA/CATGAA`	1	--	us2k¹ tfbs³		13		NS EA NA CSA	1331
rs180814369^1,2		--	105935592(+)	`ATTGAC/TCATAA`	1	--	us2k¹		0	--	--	--	--
rs151129895^1,2		--	105935637(+)	`ATTATA/GTGAAT`	1	--	us2k¹		0	--	--	--	--
rs7884740^1,2	C,	--	105935681(+)	`GTACCA/CGGTAC`	1	--	us2k¹		0	--	--	--	--
rs146846807^1,2		--	105935699(+)	`GGGTAC/TGCTAA`	1	--	us2k¹		0	--	--	--	--
rs186094228^1,2		--	105935727(+)	`TGATAC/TGATAG`	1	--	us2k¹		0	--	--	--	--
rs139264071^1,2	C,	--	105935886(+)	`AAAGCA/GGACAA`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for RNF128 (105937024 - 106040246 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for RNF128
1 CNV: 8310
Locus Specific Mutation Databases (LSDB): RNF128

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNF128

DNA2.0 Custom Variant and Variant Library Synthesis for RNF128

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RNF128 for disorders           About GeneDecksing

OMIM gene information: 300439    OMIM disorders: --

3 diseases for RNF128:    About MalaCards

cor pulmonale ulcerative colitis hematopoiesis

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(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for RNF128 gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with RNF128)

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GRAIL: an E3 ubiquitin ligase that inhibits cytokine gene transcription is expressed in anergic CD4+ T cells. (PubMed id 12705856)^{1, 2, 9} Anandasabapathy N.... Soares L. (2003)
The DNA sequence of the human X chromosome. (PubMed id 15772651)^{1, 2} Ross M.T.... Bentley D.R. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Systematic analysis of dimeric E3-RING interactions re veals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)¹ Woodsmith J....Sanderson C.M. (2012)
Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. (PubMed id 19549727)¹ Markson G....Sanderson C.M. (2009)
The transmembrane E3 ligase GRAIL ubiquitinates and degrades CD83 on CD4 T cells. (PubMed id 19542455)¹ Su L.L....Fathman C.G. (2009)
Naive CD4 t cell proliferation is controlled by mammalian target of rapamycin regulation of GRAIL expression. (PubMed id 19414743)¹ Lin J.T....Wu L. (2009)
Cutting edge: The transmembrane E3 ligase GRAIL ubiquitinates the costimulatory molecule CD40 ligand during the induction of T cell anergy. (PubMed id 18641297)¹ Lineberry N.B....Fathman C.G. (2008)
The single subunit transmembrane E3 ligase gene related to anergy in lymphocytes (GRAIL) captures and then ubiquitinates transmembrane proteins across the cell membrane. (PubMed id 18713730)¹ Lineberry N....Fathman C.G. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 79589	HGNC: 21153	AceView: RNF128	Ensembl:ENSG00000133135	euGenes: HUgn79589
ECgene: RNF128	H-InvDB: RNF128

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for RNF128	Pharmacogenomics, SNPs, Pathways

Intellectual Property for RNF128 gene
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Patent Information for RNF128 gene:
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RNF128 Gene

ring finger protein 128, E3 ubiquitin protein ligase

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RNF128 Gene

ring finger protein 128, E3 ubiquitin protein ligase

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