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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RNF128 Gene

protein-coding   GIFtS: 58
GCID: GC0XP105937

Ring Finger Protein 128, E3 Ubiquitin Protein Ligase

(Previous name: ring finger protein 128)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ring Finger Protein 128, E3 Ubiquitin Protein Ligase1 2     E3 Ubiquitin-Protein Ligase RNF1282
GRAIL2 3 5     EC 6.3.2.-3
RING Finger Protein 1281 3     EC 6.3.28
Gene Related To Anergy In Lymphocytes Protein2 3     

External Ids:    HGNC: 211531   Entrez Gene: 795892   Ensembl: ENSG000001331357   OMIM: 3004395   UniProtKB: Q8TEB73   

Export aliases for RNF128 gene to outside databases

Previous GC identifers: GC0XP103969 GC0XP104708 GC0XP105743 GC0XP105823 GC0XP095565


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RNF128 Gene:
The protein encoded by this gene is a type I transmembrane protein that localizes to the endocytic pathway. This
protein contains a RING zinc-finger motif and has been shown to possess E3 ubiquitin ligase activity. Expression
of this gene in retrovirally transduced T cell hybridoma significantly inhibits activation-induced IL2 and IL4
cytokine production. Induced expression of this gene was observed in anergic CD4(+) T cells, which suggested a
role in the induction of anergic phenotype. Alternatively spliced transcript variants encoding distinct isoforms
have been reported. (provided by RefSeq, Jul 2008)

GeneCards Summary for RNF128 Gene: 
RNF128 (ring finger protein 128, E3 ubiquitin protein ligase) is a protein-coding gene. Diseases associated with RNF128 include cor pulmonale, and ulcerative colitis, and among its related super-pathways are Calcium signaling in the CD4+ TCR pathway. GO annotations related to this gene include ubiquitin-protein ligase activity and zinc ion binding. An important paralog of this gene is ZNRF3.

UniProtKB/Swiss-Prot: RN128_HUMAN, Q8TEB7
Function: E3 ubiquitin-protein ligase that catalyzes polyubiquitin chains. Functions as an inhibitor of cytokine
gene transcription. Inhibits IL2 and IL4 transcription and this activity is likely to be mediated by E3 ligase
activity. Plays an important role in the induction of the anergic phenotype. Functions in the patterning of the
dorsal ectoderm; sensitizes ectoderm to respond to neural-inducing signals (By similarity)

Gene Wiki entry for RNF128 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.2  NT_011651.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RNF128 gene promoter:
         Bach1   HOXA9   HOXA9B   STAT1   USF1   LCR-F1   Meis-1b   USF-1   Zic3   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RNF128 promoter sequence
   Search SABiosciences Chromatin IP Primers for RNF128

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF128


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq22.3   Ensembl cytogenetic band:  Xq22.3   HGNC cytogenetic band: Xq22.3

RNF128 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF128 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP105937:  view genomic region     (about GC identifiers)

Start:
105,937,024 bp from pter      End:
106,040,246 bp from pter
Size:
103,223 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RN128_HUMAN, Q8TEB7 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase RNF128 precursor  
Size: 428 amino acids; 46521 Da
Subcellular location: Endomembrane system; Single-pass membrane protein (By similarity). Cytoplasm, perinuclear
region (By similarity). Note=Localized in an asymmetric perinuclear punctate manner. Localizes to the internal
pool of the transferrin recycling endosomal pathway. Partially colocalized with the endoplasmic reticulum
resident HSPA5, with Golgi resident STX5, and with the late endosomal GTPase RAB7A (By similarity)
Sequence caution: Sequence=BAB15682.1; Type=Frameshift; Positions=291;
1 PDB 3D structure from and Proteopedia for RNF128:
3ICU (3D)    
Secondary accessions: Q6PH80 Q6ZTJ8 Q96RF3 Q9H5E4
Alternative splicing: 2 isoforms:  Q8TEB7-1   Q8TEB7-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RNF128: NX_Q8TEB7

Explore proteomics data for RNF128 at MOPED 

Post-translational modifications:

  • UniProtKB: Auto-ubiquitinated. Controls the development of T-cell clonal anergy by ubiquitination
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8TEB7

  • 4/9 DME Specific Peptides for RNF128 (Q8TEB7) (see all 9)
     VRILTCNH  QVTMVIEVG  VAIMIGNLKG  ALIQRGGGCTF 

    RNF128 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RNF128 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_078815.3  NP_919445.1  

    ENSEMBL proteins: 
     ENSP00000412610   ENSP00000316127   ENSP00000255499  

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    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005770late endosome IEA--
    GO:0005783endoplasmic reticulum IEA--
    GO:0005794Golgi apparatus IEA--
    GO:0012505endomembrane system IEA--
    GO:0016021integral to membrane IEA--

    RNF128 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RNF: RING-type (C3HC4) zinc fingers

    3 InterPro protein domains:
     IPR001841 Znf_RING
     IPR003137 Protease-assoc_domain
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q8TEB7

    ProtoNet protein and cluster: Q8TEB7

    2 Blocks protein domains:
    IPB001841 Zn-finger
    IPB003137 Protease-associated PA


    UniProtKB/Swiss-Prot: RN128_HUMAN, Q8TEB7
    Domain: Binding to E2 ubiquitin-conjugating enzyme requires an intact RING finger domain
    Similarity: Contains 1 PA (protease associated) domain
    Similarity: Contains 1 RING-type zinc finger


    RNF128 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RN128_HUMAN, Q8TEB7
    Function: E3 ubiquitin-protein ligase that catalyzes polyubiquitin chains. Functions as an inhibitor of cytokine
    gene transcription. Inhibits IL2 and IL4 transcription and this activity is likely to be mediated by E3 ligase
    activity. Plays an important role in the induction of the anergic phenotype. Functions in the patterning of the
    dorsal ectoderm; sensitizes ectoderm to respond to neural-inducing signals (By similarity)
    Induction: Induced under anergic conditions. Up-regulated during T-cell anergy induction following signaling
    through the T-cell antigen receptor

         Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IEA--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0046872metal ion binding ----
         
    RNF128 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RNF128:
     Synthetic lethal with Ras 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Rnf128):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  nervous system 
     respiratory system 

    RNF128 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for RNF128: Rnf128tm1.1Flv Rnf128tm1Cdon

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    SwitchGear 3'UTR luciferase reporter plasmidRNF128 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RNF128 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Calcium signaling in the CD4+ TCR pathway
    Calcineurin-regulated NFAT-dependent transcription in lymphocytes0.38


    1 BioSystems Pathway for RNF128
        Calcineurin-regulated NFAT-dependent transcription in lymphocytes



    UniProtKB/Swiss-Prot: RN128_HUMAN, Q8TEB7
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNF128

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/11 Interacting proteins for RNF128 (Q8TEB73 ENSP000002554994) via UniProtKB, MINT, STRING, and/or I2D (see all 11)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD151P485093, ENSP000003241014I2D: score=2 STRING: ENSP00000324101
    CD40LGP299653, ENSP000003596634I2D: score=2 STRING: ENSP00000359663
    UBE2IP632793, ENSP000003248974I2D: score=2 STRING: ENSP00000324897
    UBE2NP610883, ENSP000003161764I2D: score=2 STRING: ENSP00000316176
    USP8P408183, ENSP000003022394I2D: score=1 STRING: ENSP00000302239
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0042036negative regulation of cytokine biosynthetic process IEA--

    RNF128 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for RNF128 (RN128)

    4 HMDB Compounds for RNF128    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    Search CenterWatch for drugs/clinical trials and news about RNF128 / RN128

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RNF128 gene (2 alternative transcripts): 
    NM_024539.3  NM_194463.1  

    Unigene Cluster for RNF128:

    Ring finger protein 128, E3 ubiquitin protein ligase
    Hs.496542  [show with all ESTs]
    Unigene Representative Sequence: NM_194463
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000418562 ENST00000324342(uc004emk.3) ENST00000255499(uc004eml.3)

    miRNA
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    Additional mRNA sequence: 

    AF394689.1 AK027169.1 AK074264.1 AK126553.1 BC012931.1 BC030951.1 BC036901.1 BC056677.1 
    BC063404.1 

    2 DOTS entries:

    DT.40237109  DT.97768736 

    24/124 AceView cDNA sequences (see all 124):

    AK074264 BF593954 BE536963 NM_194463 BC063404 BU173514 AA595575 AI682800 
    AK126553 BM506687 AA554040 BC012931 AW613123 BI963863 BI792320 AI580191 
    NM_024539 BM460110 BI964160 AV692456 CD107148 BC056677 BI715115 BG165006 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for RNF128    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
    SP1:                                                                        
    SP2:                    -                                                   
    SP3:                    -                                                   
    SP4:                                                                        


    ECgene alternative splicing isoforms for RNF128

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RNF128 expression in normal human tissues (normalized intensities)      RNF128 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    RNF128 Expression
    About this image


    RNF128 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/18 selected tissues (see all 18) fully expand
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 3 entries
             Ureter
             visceral organ   
     
     Kidney (Urinary System)    fully expand to see all 3 entries
             Metanephros
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Hypothalamus
             ganglion/cranial   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             limb/hindlimb   

    See RNF128 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RNF128

    SOURCE GeneReport for Unigene cluster: Hs.496542
        SABiosciences Expression via Pathway-Focused PCR Arrays including RNF128: 
              T-Cell Anergy & Immune Tolerance in human mouse rat
              Ubiquitin Ligases in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF128

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RNF128 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnf1281 , 5 ring finger protein 1281, 5 91.51(n)1
    95.33(a)1
      X (61.35 cM)5
    668891  NM_023270.51  NP_075759.31 
     1395633165 
    chicken
    (Gallus gallus)
    Aves RNF1281 ring finger protein 128 71.97(n)
    69.44(a)
      422382  XM_420351.3  XP_420351.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    54(a)
    1 → many
    GL343842.1(8227-32438)
    African clawed frog
    (Xenopus laevis)
    Amphibia rnf128-A2 ring finger protein 128/E3 ubiquitin ligase 75.69(n)    AY112655.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb57h052 Transcribed sequence with weak similarity to protein more 76.22(n)    CA471513.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta gol6
    goliath
    18(a)
    1 → many
    2R(20960150-20971843)
    worm
    (Caenorhabditis elegans)
    Secernentea H10E21.56
    Protein H10E21.5
    18(a)
    1 → many
    III(20527-23962)


    ENSEMBL Gene Tree for RNF128 (if available)
    TreeFam Gene Tree for RNF128 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RNF128 gene
    ZNRF32  RNF432  RNF1482  RNF1492  RNF1332  RNF1502  RNF1302  RNF1672  
    RNF2152  ZNRF42  RNF132  
    6 SIMAP similar genes for RNF128 using alignment to 3 protein entries:     RN128_HUMAN (see all proteins):
    RNF148    RNF133    RNF130    LOC284996    RNF150    RNF149

    RNF128 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1263 SNPs in RNF128 are shown (see all 1263)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs78852821,2
    C,F,H--105906993(+) GTAACT/ATCTCA 1 -- us2k15Minor allele frequency- A:0.02NS EA WA 420
    rs1861239641,2
    --105907185(+) AATAAC/TAATAA 1 -- us2k10--------
    rs1894112781,2
    --105907247(+) TTGTGA/GTCCTA 1 -- us2k10--------
    rs59623561,2
    C,F,A,H--105907288(+) AAAATA/CATGAA 1 -- us2k1 tfbs313Minor allele frequency- C:0.26NS EA NA CSA 1331
    rs1808143691,2
    --105907319(+) ATTGAC/TCATAA 1 -- us2k10--------
    rs1511298951,2
    --105907364(+) ATTATA/GTGAAT 1 -- us2k10--------
    rs78847401,2
    C--105907408(+) GTACCA/CGGTAC 1 -- us2k10--------
    rs1468468071,2
    --105907426(+) GGGTAC/TGCTAA 1 -- us2k10--------
    rs1860942281,2
    --105907454(+) TGATAC/TGATAG 1 -- us2k10--------
    rs1392640711,2
    C--105907613(+) AAAGCA/GGACAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RNF128 (105937024 - 106040246 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for RNF128:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2667443CNV Deletion23128226
    nsv510852CNV Loss20534489
    esv2752312CNV Gain17911159


    Human Gene Mutation Database (HGMD): RNF128

    Locus Specific Mutation Databases (LSDB): RNF128
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing RNF128
    DNA2.0 Custom Variant and Variant Library Synthesis for RNF128

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300439    OMIM disorders: --

    2 diseases for RNF128:    About MalaCards
    cor pulmonale    ulcerative colitis


    RNF128 for disorders           About GeneDecksing


    Export disorders for RNF128 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RNF128 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with RNF128)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. GRAIL: an E3 ubiquitin ligase that inhibits cytokine gene transcription is expressed in anergic CD4+ T cells. (PubMed id 12705856)1, 2, 9 Anandasabapathy N.... Soares L. (2003)
    2. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. (PubMed id 19549727)1 Markson G....Sanderson C.M. (2009)
    6. The transmembrane E3 ligase GRAIL ubiquitinates and degrades CD83 on CD4 T cells. (PubMed id 19542455)1 Su L.L....Fathman C.G. (2009)
    7. Naive CD4 t cell proliferation is controlled by mammalian target of rapamycin regulation of GRAIL expression. (PubMed id 19414743)1 Lin J.T....Wu L. (2009)
    8. Cutting edge: The transmembrane E3 ligase GRAIL ubiquitinates the costimulatory molecule CD40 ligand during the induction of T cell anergy. (PubMed id 18641297)1 Lineberry N.B....Fathman C.G. (2008)
    9. The single subunit transmembrane E3 ligase gene related to anergy in lymphocytes (GRAIL) captures and then ubiquitinates transmembrane proteins across the cell membrane. (PubMed id 18713730)1 Lineberry N....Fathman C.G. (2008)
    10. Upregulation of GRAIL is associated with remission of ulcerative colitis. (PubMed id 18467499)1 Egawa S....Hayashi N. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79589 HGNC: 21153 AceView: RNF128 Ensembl:ENSG00000133135 euGenes: HUgn79589
    ECgene: RNF128 H-InvDB: RNF128

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RNF128 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RNF128 gene:
    Search GeneIP for patents involving RNF128

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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