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Aliases for RNF128 Gene

Aliases for RNF128 Gene

  • Ring Finger Protein 128, E3 Ubiquitin Protein Ligase 2 3 5
  • Gene Related To Anergy In Lymphocytes Protein 3 4
  • GRAIL 3 4
  • Ring Finger Protein 128 2
  • RING Finger Protein 128 4
  • EC 6.3.2.- 4
  • EC 6.3.2 63

External Ids for RNF128 Gene

Previous GeneCards Identifiers for RNF128 Gene

  • GC0XP103969
  • GC0XP104708
  • GC0XP105743
  • GC0XP105823
  • GC0XP105937
  • GC0XP095565

Summaries for RNF128 Gene

Entrez Gene Summary for RNF128 Gene

  • The protein encoded by this gene is a type I transmembrane protein that localizes to the endocytic pathway. This protein contains a RING zinc-finger motif and has been shown to possess E3 ubiquitin ligase activity. Expression of this gene in retrovirally transduced T cell hybridoma significantly inhibits activation-induced IL2 and IL4 cytokine production. Induced expression of this gene was observed in anergic CD4(+) T cells, which suggested a role in the induction of anergic phenotype. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for RNF128 Gene

RNF128 (Ring Finger Protein 128, E3 Ubiquitin Protein Ligase) is a Protein Coding gene. Diseases associated with RNF128 include hartnup disorder. Among its related pathways are Calcineurin-regulated NFAT-dependent transcription in lymphocytes. GO annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is RNF167.

UniProtKB/Swiss-Prot for RNF128 Gene

  • E3 ubiquitin-protein ligase that catalyzes Lys-48- and Lys-63-linked polyubiquitin chains formation. Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription, thereby playing an important role in the induction of the anergic phenotype, a long-term stable state of T-lymphocyte unresponsiveness to antigenic stimulation associated with the blockade of interleukin production. Ubiquitinates ARPC5 with Lys-48 linkages and COR1A with Lys-63 linkages leading to their degradation, down-regulation of these cytosleletal components results in impaired lamellipodium formation and reduced accumulation of F-actin at the immunological synapse. Functions in the patterning of the dorsal ectoderm; sensitizes ectoderm to respond to neural-inducing signals.

Gene Wiki entry for RNF128 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF128 Gene

Genomics for RNF128 Gene

Regulatory Elements for RNF128 Gene

Promoters for RNF128 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RNF128 on UCSC Golden Path with GeneCards custom track

Genomic Location for RNF128 Gene

Chromosome:
X
Start:
106,693,794 bp from pter
End:
106,797,016 bp from pter
Size:
103,223 bases
Orientation:
Plus strand

Genomic View for RNF128 Gene

Genes around RNF128 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF128 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF128 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF128 Gene

Proteins for RNF128 Gene

  • Protein details for RNF128 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TEB7-RN128_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase RNF128
    Protein Accession:
    Q8TEB7
    Secondary Accessions:
    • A0PJI4
    • Q6PH80
    • Q6ZTJ8
    • Q96RF3
    • Q9H5E4

    Protein attributes for RNF128 Gene

    Size:
    428 amino acids
    Molecular mass:
    46521 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB15682.1; Type=Frameshift; Positions=291; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RNF128 Gene

    Alternative splice isoforms for RNF128 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNF128 Gene

Proteomics data for RNF128 Gene at MOPED

Post-translational modifications for RNF128 Gene

  • Auto-ubiquitinated. Controls the development of T-cell clonal anergy by ubiquitination.
  • Glycosylation at Asn 48, Asn 59, and Asn 101
  • Modification sites at PhosphoSitePlus

Other Protein References for RNF128 Gene

Antibody Products

  • R&D Systems Antibodies for RNF128 (GRAIL/RNF128)

Domains & Families for RNF128 Gene

Gene Families for RNF128 Gene

Protein Domains for RNF128 Gene

Suggested Antigen Peptide Sequences for RNF128 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TEB7

UniProtKB/Swiss-Prot:

RN128_HUMAN :
  • Binding to E2 ubiquitin-conjugating enzyme requires an intact RING finger domain.
  • Contains 1 RING-type zinc finger.
Domain:
  • Binding to E2 ubiquitin-conjugating enzyme requires an intact RING finger domain.
  • Contains 1 PA (protease associated) domain.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF128: view

Function for RNF128 Gene

Molecular function for RNF128 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase that catalyzes Lys-48- and Lys-63-linked polyubiquitin chains formation. Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription, thereby playing an important role in the induction of the anergic phenotype, a long-term stable state of T-lymphocyte unresponsiveness to antigenic stimulation associated with the blockade of interleukin production. Ubiquitinates ARPC5 with Lys-48 linkages and COR1A with Lys-63 linkages leading to their degradation, down-regulation of these cytosleletal components results in impaired lamellipodium formation and reduced accumulation of F-actin at the immunological synapse. Functions in the patterning of the dorsal ectoderm; sensitizes ectoderm to respond to neural-inducing signals.
UniProtKB/Swiss-Prot Induction:
Induced under anergic conditions. Up-regulated during T-cell anergy induction following signaling through the T-cell antigen receptor.

Enzyme Numbers (IUBMB) for RNF128 Gene

Gene Ontology (GO) - Molecular Function for RNF128 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with RNF128: view
genes like me logo Genes that share phenotypes with RNF128: view

Animal Models for RNF128 Gene

MGI Knock Outs for RNF128:

Animal Model Products

  • Taconic Biosciences Mouse Models for RNF128

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RNF128 Gene

Localization for RNF128 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF128 Gene

Endomembrane system; Single-pass membrane protein. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Note=Localized in an asymmetric perinuclear punctate manner. Localizes to the internal pool of the transferrin recycling endosomal pathway. Partially colocalized with the endoplasmic reticulum resident HSPA5, with Golgi resident STX5, and with the late endosomal GTPase RAB7A (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNF128 Gene COMPARTMENTS Subcellular localization image for RNF128 gene
Compartment Confidence
cytoskeleton 3
endoplasmic reticulum 3
endosome 2
extracellular 2
golgi apparatus 2
plasma membrane 2
cytosol 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RNF128 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005770 late endosome IEA --
genes like me logo Genes that share ontologies with RNF128: view

Pathways & Interactions for RNF128 Gene

genes like me logo Genes that share pathways with RNF128: view

Pathways by source for RNF128 Gene

UniProtKB/Swiss-Prot Q8TEB7-RN128_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for RNF128 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0061462 protein localization to lysosome IC 25635054
GO:1904352 positive regulation of protein catabolic process in the vacuole IC 25635054
genes like me logo Genes that share ontologies with RNF128: view

No data available for SIGNOR curated interactions for RNF128 Gene

Drugs & Compounds for RNF128 Gene

(3) Drugs for RNF128 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Diphosphate Experimental Pharma 0

(1) Additional Compounds for RNF128 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
genes like me logo Genes that share compounds with RNF128: view

Transcripts for RNF128 Gene

Unigene Clusters for RNF128 Gene

Ring finger protein 128, E3 ubiquitin protein ligase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF128 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1:
SP2: -
SP3: -
SP4:

Relevant External Links for RNF128 Gene

GeneLoc Exon Structure for
RNF128
ECgene alternative splicing isoforms for
RNF128

Expression for RNF128 Gene

mRNA expression in normal human tissues for RNF128 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNF128 Gene

This gene is overexpressed in Liver (x9.0) and Adrenal Gland (x6.3).

Protein differential expression in normal tissues from HIPED for RNF128 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RNF128 Gene



SOURCE GeneReport for Unigene cluster for RNF128 Gene Hs.496542

genes like me logo Genes that share expression patterns with RNF128: view

Protein tissue co-expression partners for RNF128 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for RNF128 Gene

Orthologs for RNF128 Gene

This gene was present in the common ancestor of animals.

Orthologs for RNF128 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RNF128 35
  • 92.29 (n)
  • 94.63 (a)
RNF128 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNF128 35
  • 93.38 (n)
  • 96.73 (a)
RNF128 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnf128 35
  • 91.51 (n)
  • 95.33 (a)
Rnf128 16
Rnf128 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnf128 35
  • 90.73 (n)
  • 95.33 (a)
oppossum
(Monodelphis domestica)
Mammalia RNF128 36
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RNF128 36
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RNF128 36
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves RNF128 35
  • 71.97 (n)
  • 69.44 (a)
-- 36
  • 63 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 56 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia rnf128-A 35
zebrafish
(Danio rerio)
Actinopterygii rnf128a 35
  • 59.04 (n)
  • 58.13 (a)
wufb57h05 35
rnf128a 36
  • 53 (a)
ManyToMany
si:dkeyp-86f7.4 36
  • 39 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea H10E21.5 36
  • 18 (a)
OneToMany
Species with no ortholog for RNF128:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RNF128 Gene

ENSEMBL:
Gene Tree for RNF128 (if available)
TreeFam:
Gene Tree for RNF128 (if available)

Paralogs for RNF128 Gene

(5) SIMAP similar genes for RNF128 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RNF128: view

Variants for RNF128 Gene

Sequence variations from dbSNP and Humsavar for RNF128 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1991340 -- 106,693,176(-) CCCCA(C/T)GTGTT upstream-variant-2KB
rs1954612 -- 106,752,747(+) cagag(A/G)tatgt intron-variant
rs2880013 -- 106,773,321(-) ATAAA(A/C)CTTTG intron-variant
rs3037086 -- 106,693,399(-) TCTCT(C/G)TGTGT upstream-variant-2KB
rs3037090 -- 106,693,361(-) tgtgt(-/GT)tTTCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RNF128 Gene

Variant ID Type Subtype PubMed ID
esv2752312 CNV Gain 17911159
nsv510852 CNV Loss 20534489
esv2667443 CNV Deletion 23128226

Variation tolerance for RNF128 Gene

Residual Variation Intolerance Score: 75.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.91; 18.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNF128 Gene

HapMap Linkage Disequilibrium report
RNF128
Human Gene Mutation Database (HGMD)
RNF128

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF128 Gene

Disorders for RNF128 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RNF128 Gene - From: DISEASES

Disorder Aliases PubMed IDs
hartnup disorder
  • hartnup disease
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for RNF128

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RNF128
genes like me logo Genes that share disorders with RNF128: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RNF128 Gene

Publications for RNF128 Gene

  1. GRAIL: an E3 ubiquitin ligase that inhibits cytokine gene transcription is expressed in anergic CD4+ T cells. (PMID: 12705856) Anandasabapathy N. … Soares L. (Immunity 2003) 3 4 23 67
  2. CD81 promotes both the degradation of transferrin receptor 2 (TfR2) and the Tfr2-mediated maintenance of hepcidin expression. (PMID: 25635054) Chen J. … Enns C.A. (J. Biol. Chem. 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Grail as a molecular determinant for the functions of the tumor suppressor p53 in tumorigenesis. (PMID: 23370271) Chen Y.C. … Huang S.M. (Cell Death Differ. 2013) 3
  5. Regulation of anergy-related ubiquitin E3 ligase, GRAIL, in murine models of colitis and patients with Crohn's disease. (PMID: 24356810) Mukai A. … Takehara T. (J. Gastroenterol. 2013) 3

Products for RNF128 Gene

Sources for RNF128 Gene

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