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Aliases for RNF126 Gene

Aliases for RNF126 Gene

  • Ring Finger Protein 126 2 3
  • RING Finger Protein 126 4
  • EC 6.3.2.- 4

External Ids for RNF126 Gene

Summaries for RNF126 Gene

Entrez Gene Summary for RNF126 Gene

  • The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. [provided by RefSeq, Jul 2008]

GeneCards Summary for RNF126 Gene

RNF126 (Ring Finger Protein 126) is a Protein Coding gene. GO annotations related to this gene include ligase activity. An important paralog of this gene is PJA1.

UniProtKB/Swiss-Prot for RNF126 Gene

  • E3 ubiquitin-protein ligase that regulates several biological processes through ubiquitination of various target proteins. Depending on the associated E2 ligase, mediates Lys-48- and Lys-63-linked polyubiquitination of substrates. Through their polyubiquitination, may play a role in the endosomal sorting and degradation of several membrane receptors including EGFR, FLT3, MET and CXCR4. May also be part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome. May provide the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the mislocalized proteins and their targeting to the proteasome (PubMed:24981174). May also play a role in the endosomal recycling of IGF2R, the cation-independent mannose-6-phosphate receptor (PubMed:24275455). By ubiquitinating CDKN1A/p21 and targeting it for degradation, may also promote cell proliferation (PubMed:23026136). May monoubiquitinate AICDA (PubMed:23277564).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF126 Gene

Genomics for RNF126 Gene

Genomic Location for RNF126 Gene

Start:
647,526 bp from pter
End:
663,313 bp from pter
Size:
15,788 bases
Orientation:
Minus strand

Genomic View for RNF126 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNF126 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF126 Gene

Regulatory Elements for RNF126 Gene

Transcription factor binding sites by QIAGEN in the RNF126 gene promoter:

Proteins for RNF126 Gene

  • Protein details for RNF126 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BV68-RN126_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase RNF126
    Protein Accession:
    Q9BV68
    Secondary Accessions:
    • Q9NWX1

    Protein attributes for RNF126 Gene

    Size:
    326 amino acids
    Molecular mass:
    35585 Da
    Quaternary structure:
    • Interacts with CCDC50, EGFR, FLT3 and SCAMP3. Interacts with BAG6 (via ubiquitin-like domain); required for BAG6-dependent ubiquitination of proteins mislocalized to the cytosol. Interacts with CDKN1A. Interacts with AICDA.

    Alternative splice isoforms for RNF126 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNF126 Gene

Proteomics data for RNF126 Gene at MOPED

Post-translational modifications for RNF126 Gene

Other Protein References for RNF126 Gene

No data available for DME Specific Peptides for RNF126 Gene

Domains for RNF126 Gene

Gene Families for RNF126 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for RNF126 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for RNF126 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BV68

UniProtKB/Swiss-Prot:

RN126_HUMAN
Similarity:
  • Contains 1 RING-type zinc finger.:
    • Q9BV68
genes like me logo Genes that share domains with RNF126: view

Function for RNF126 Gene

Molecular function for RNF126 Gene

UniProtKB/Swiss-Prot Function: E3 ubiquitin-protein ligase that regulates several biological processes through ubiquitination of various target proteins. Depending on the associated E2 ligase, mediates Lys-48- and Lys-63-linked polyubiquitination of substrates. Through their polyubiquitination, may play a role in the endosomal sorting and degradation of several membrane receptors including EGFR, FLT3, MET and CXCR4. May also be part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome. May provide the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the mislocalized proteins and their targeting to the proteasome (PubMed:24981174). May also play a role in the endosomal recycling of IGF2R, the cation-independent mannose-6-phosphate receptor (PubMed:24275455). By ubiquitinating CDKN1A/p21 and targeting it for degradation, may also promote cell proliferation (PubMed:23026136). May monoubiquitinate AICDA (PubMed:23277564).

Enzyme Numbers (IUBMB) for RNF126 Gene

Gene Ontology (GO) - Molecular Function for RNF126 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005154 epidermal growth factor receptor binding IEA --
GO:0005515 protein binding IPI 14667819
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with RNF126: view

miRNA for RNF126 Gene

miRTarBase miRNAs that target RNF126

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RNF126 Gene

Localization for RNF126 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF126 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNF126 Gene COMPARTMENTS Subcellular localization image for RNF126 gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for RNF126 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 23026136
GO:0005737 cytoplasm IDA 23026136
genes like me logo Genes that share ontologies with RNF126: view

Pathways for RNF126 Gene

SuperPathways for RNF126 Gene

No Data Available

UniProtKB/Swiss-Prot Q9BV68-RN126_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for RNF126 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006513 protein monoubiquitination IDA 23277564
GO:0032880 regulation of protein localization --
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway IMP 23418353
GO:0042127 regulation of cell proliferation IMP 23026136
GO:0042147 retrograde transport, endosome to Golgi IMP 24275455
genes like me logo Genes that share ontologies with RNF126: view

No data available for Pathways by source for RNF126 Gene

Transcripts for RNF126 Gene

Unigene Clusters for RNF126 Gene

Ring finger protein 126:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNF126 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11a · 11b · 11c ·
SP1: - - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - - -
SP7: - -
SP8: - - - -
SP9: - - - - -
SP10: - - -
SP11:
SP12:
SP13: - -

ExUns: 11d · 11e
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for RNF126 Gene

GeneLoc Exon Structure for
RNF126
ECgene alternative splicing isoforms for
RNF126

Expression for RNF126 Gene

mRNA expression in normal human tissues for RNF126 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RNF126 Gene

SOURCE GeneReport for Unigene cluster for RNF126 Gene Hs.69554

mRNA Expression by UniProt/SwissProt for RNF126 Gene

Q9BV68-RN126_HUMAN
Tissue specificity: Highly expressed in liver and testis.
genes like me logo Genes that share expressions with RNF126: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RNF126 Gene

Orthologs for RNF126 Gene

This gene was present in the common ancestor of animals.

Orthologs for RNF126 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNF126 35
  • 97.53 (n)
  • 98.04 (a)
RNF126 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RNF126 35
  • 90.32 (n)
  • 92.26 (a)
RNF126 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC485101 35
  • 91.26 (n)
  • 94.41 (a)
RNF126 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnf126 35
  • 87.14 (n)
  • 94.21 (a)
Rnf126 16
Rnf126 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RNF126 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RNF126 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnf126 35
  • 87.89 (n)
  • 94.53 (a)
chicken
(Gallus gallus)
Aves RNF126 35
  • 75.38 (n)
  • 82.58 (a)
RNF126 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RNF126 36
  • 72 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC69096 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf126 35
  • 68.2 (n)
  • 74.47 (a)
Str.11305 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4466 35
zebrafish
(Danio rerio)
Actinopterygii CU570683.1 36
  • 68 (a)
OneToMany
rnf126 35
  • 70.04 (n)
  • 77.12 (a)
rnf126 36
  • 81 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG11982 35
  • 49.36 (n)
  • 35.11 (a)
CG11982 36
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y54E10BR.3 36
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
OneToMany
Species with no ortholog for RNF126:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RNF126 Gene

ENSEMBL:
Gene Tree for RNF126 (if available)
TreeFam:
Gene Tree for RNF126 (if available)

Paralogs for RNF126 Gene

Paralogs for RNF126 Gene

Selected SIMAP similar genes for RNF126 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for RNF126 Gene

genes like me logo Genes that share paralogs with RNF126: view

Variants for RNF126 Gene

Sequence variations from dbSNP and Humsavar for RNF126 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs14218 -- 648,224(-) GCCAC(A/G)AACCC synonymous-codon, reference
rs757331 -- 647,251(+) TGACC(A/G)AAGCG downstream-variant-500B
rs916904 -- 663,929(+) GGAGA(A/G)GGCAG upstream-variant-2KB
rs929263 -- 663,373(+) TCCGG(C/T)GGGGG upstream-variant-2KB
rs1009628 -- 658,013(+) GGGGC(A/G)GCACG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNF126 Gene

Variant ID Type Subtype PubMed ID
nsv428360 CNV Gain 18775914
nsv910102 CNV Loss 21882294
nsv910109 CNV Loss 21882294
nsv470101 CNV Loss 18288195
dgv3508n71 CNV Loss 21882294
dgv3510n71 CNV Loss 21882294
dgv3511n71 CNV Loss 21882294
dgv3513n71 CNV Loss 21882294
dgv3514n71 CNV Gain 21882294
dgv3515n71 CNV Loss 21882294
dgv3516n71 CNV Loss 21882294
dgv3519n71 CNV Gain+Loss 21882294
dgv3525n71 CNV Loss 21882294
dgv3526n71 CNV Loss 21882294
dgv3528n71 CNV Loss 21882294
dgv3530n71 CNV Gain 21882294
dgv3531n71 CNV Loss 21882294
nsv910224 CNV Loss 21882294
dgv3532n71 CNV Gain 21882294
dgv3533n71 CNV Gain+Loss 21882294
dgv3534n71 CNV Loss 21882294
dgv3536n71 CNV Gain 21882294
dgv3537n71 CNV Loss 21882294
nsv910246 CNV Gain+Loss 21882294
dgv3538n71 CNV Gain 21882294
dgv3539n71 CNV Loss 21882294
nsv910252 CNV Loss 21882294
nsv910253 CNV Loss 21882294
nsv910254 CNV Loss 21882294
dgv3540n71 CNV Loss 21882294

Relevant External Links for RNF126 Gene

HapMap Linkage Disequilibrium report
RNF126

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF126 Gene

Disorders for RNF126 Gene

No disorders were found for RNF126 Gene.

No data available for UniProtKB/Swiss-Prot for RNF126 Gene

Publications for RNF126 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. E3 ubiquitin ligase RNF126 promotes cancer cell proliferation by targeting the tumor suppressor p21 for ubiquitin-mediated degradation. (PMID: 23026136) Zhi X. … Chen C. (Cancer Res. 2013) 3 4
  4. Solubility-based genetic screen identifies RING finger protein 126 as an E3 ligase for activation-induced cytidine deaminase. (PMID: 23277564) Delker R.K. … Papavasiliou F.N. (Proc. Natl. Acad. Sci. U.S.A. 2013) 3 4
  5. The E3 ubiquitin ligases RNF126 and Rabring7 regulate endosomal sorting of the epidermal growth factor receptor. (PMID: 23418353) Smith C.J. … McGlade C.J. (J. Cell. Sci. 2013) 3 4

Products for RNF126 Gene

Sources for RNF126 Gene

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