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Aliases for RNF126 Gene

Aliases for RNF126 Gene

  • Ring Finger Protein 126 2 3
  • RING Finger Protein 126 4 5
  • EC 6.3.2.- 4

External Ids for RNF126 Gene

Previous GeneCards Identifiers for RNF126 Gene

  • GC19M000587
  • GC19M000599
  • GC19M000600
  • GC19M000601
  • GC19M000602
  • GC19M000418

Summaries for RNF126 Gene

Entrez Gene Summary for RNF126 Gene

  • The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. [provided by RefSeq, Jul 2008]

GeneCards Summary for RNF126 Gene

RNF126 (Ring Finger Protein 126) is a Protein Coding gene. Among its related pathways are Antigen processing- Ubiquitination and Proteasome degradation and Immune System. GO annotations related to this gene include ligase activity and epidermal growth factor receptor binding. An important paralog of this gene is PJA1.

UniProtKB/Swiss-Prot for RNF126 Gene

  • E3 ubiquitin-protein ligase that regulates several biological processes through ubiquitination of various target proteins. Depending on the associated E2 ligase, mediates Lys-48- and Lys-63-linked polyubiquitination of substrates. Through their polyubiquitination, may play a role in the endosomal sorting and degradation of several membrane receptors including EGFR, FLT3, MET and CXCR4. May also be part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome. May provide the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the mislocalized proteins and their targeting to the proteasome (PubMed:24981174). May also play a role in the endosomal recycling of IGF2R, the cation-independent mannose-6-phosphate receptor (PubMed:24275455). By ubiquitinating CDKN1A/p21 and targeting it for degradation, may also promote cell proliferation (PubMed:23026136). May monoubiquitinate AICDA (PubMed:23277564).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF126 Gene

Genomics for RNF126 Gene

Regulatory Elements for RNF126 Gene

Enhancers for RNF126 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RNF126 on UCSC Golden Path with GeneCards custom track

Promoters for RNF126 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RNF126 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the RNF126 gene promoter:

Genomic Location for RNF126 Gene

Chromosome:
19
Start:
647,526 bp from pter
End:
663,313 bp from pter
Size:
15,788 bases
Orientation:
Minus strand

Genomic View for RNF126 Gene

Genes around RNF126 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF126 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF126 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF126 Gene

Proteins for RNF126 Gene

  • Protein details for RNF126 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BV68-RN126_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase RNF126
    Protein Accession:
    Q9BV68
    Secondary Accessions:
    • Q9NWX1

    Protein attributes for RNF126 Gene

    Size:
    326 amino acids
    Molecular mass:
    35585 Da
    Quaternary structure:
    • Interacts with CCDC50, EGFR, FLT3 and SCAMP3. Interacts with BAG6 (via ubiquitin-like domain); required for BAG6-dependent ubiquitination of proteins mislocalized to the cytosol. Interacts with CDKN1A. Interacts with AICDA.

    Alternative splice isoforms for RNF126 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNF126 Gene

Proteomics data for RNF126 Gene at MOPED

Post-translational modifications for RNF126 Gene

Other Protein References for RNF126 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RNF126 Gene

Domains & Families for RNF126 Gene

Gene Families for RNF126 Gene

Protein Domains for RNF126 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for RNF126 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BV68

UniProtKB/Swiss-Prot:

RN126_HUMAN :
  • Contains 1 RING-type zinc finger.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF126: view

Function for RNF126 Gene

Molecular function for RNF126 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase that regulates several biological processes through ubiquitination of various target proteins. Depending on the associated E2 ligase, mediates Lys-48- and Lys-63-linked polyubiquitination of substrates. Through their polyubiquitination, may play a role in the endosomal sorting and degradation of several membrane receptors including EGFR, FLT3, MET and CXCR4. May also be part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome. May provide the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the mislocalized proteins and their targeting to the proteasome (PubMed:24981174). May also play a role in the endosomal recycling of IGF2R, the cation-independent mannose-6-phosphate receptor (PubMed:24275455). By ubiquitinating CDKN1A/p21 and targeting it for degradation, may also promote cell proliferation (PubMed:23026136). May monoubiquitinate AICDA (PubMed:23277564).

Enzyme Numbers (IUBMB) for RNF126 Gene

Gene Ontology (GO) - Molecular Function for RNF126 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with RNF126: view
genes like me logo Genes that share phenotypes with RNF126: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNF126 Gene

Localization for RNF126 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF126 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNF126 Gene COMPARTMENTS Subcellular localization image for RNF126 gene
Compartment Confidence
nucleus 5
cytosol 3
endosome 1
extracellular 1
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for RNF126 Gene

Pathways & Interactions for RNF126 Gene

genes like me logo Genes that share pathways with RNF126: view

UniProtKB/Swiss-Prot Q9BV68-RN126_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for RNF126 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IBA --
GO:0006513 protein monoubiquitination IDA 23277564
GO:0042127 regulation of cell proliferation IMP 23026136
GO:0042147 retrograde transport, endosome to Golgi IMP 24275455
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IMP 23026136
genes like me logo Genes that share ontologies with RNF126: view

No data available for SIGNOR curated interactions for RNF126 Gene

Drugs & Compounds for RNF126 Gene

No Compound Related Data Available

Transcripts for RNF126 Gene

Unigene Clusters for RNF126 Gene

Ring finger protein 126:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNF126 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11a · 11b · 11c ·
SP1: - - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - - -
SP7: - -
SP8: - - - -
SP9: - - - - -
SP10: - - -
SP11:
SP12:
SP13: - -

ExUns: 11d · 11e
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for RNF126 Gene

GeneLoc Exon Structure for
RNF126
ECgene alternative splicing isoforms for
RNF126

Expression for RNF126 Gene

mRNA expression in normal human tissues for RNF126 Gene

Protein differential expression in normal tissues from HIPED for RNF126 Gene

This gene is overexpressed in Testis (6.9) and Monocytes (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RNF126 Gene



SOURCE GeneReport for Unigene cluster for RNF126 Gene Hs.69554

mRNA Expression by UniProt/SwissProt for RNF126 Gene

Q9BV68-RN126_HUMAN
Tissue specificity: Highly expressed in liver and testis.
genes like me logo Genes that share expression patterns with RNF126: view

Protein tissue co-expression partners for RNF126 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RNF126 Gene

Orthologs for RNF126 Gene

This gene was present in the common ancestor of animals.

Orthologs for RNF126 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RNF126 35
  • 90.32 (n)
  • 92.26 (a)
RNF126 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC485101 35
  • 91.26 (n)
  • 94.41 (a)
RNF126 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnf126 35
  • 87.14 (n)
  • 94.21 (a)
Rnf126 16
Rnf126 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RNF126 35
  • 97.53 (n)
  • 98.04 (a)
RNF126 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnf126 35
  • 87.89 (n)
  • 94.53 (a)
oppossum
(Monodelphis domestica)
Mammalia RNF126 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RNF126 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves RNF126 35
  • 75.38 (n)
  • 82.58 (a)
RNF126 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RNF126 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf126 35
  • 68.2 (n)
  • 74.47 (a)
Str.11305 35
African clawed frog
(Xenopus laevis)
Amphibia MGC69096 35
zebrafish
(Danio rerio)
Actinopterygii rnf126 35
  • 70.04 (n)
  • 77.12 (a)
CU570683.1 36
  • 68 (a)
OneToMany
rnf126 36
  • 81 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4466 35
fruit fly
(Drosophila melanogaster)
Insecta CG11982 35
  • 49.36 (n)
  • 35.11 (a)
CG11982 36
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y54E10BR.3 36
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
OneToMany
Species with no ortholog for RNF126:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RNF126 Gene

ENSEMBL:
Gene Tree for RNF126 (if available)
TreeFam:
Gene Tree for RNF126 (if available)

Paralogs for RNF126 Gene

Paralogs for RNF126 Gene

(2) SIMAP similar genes for RNF126 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for RNF126 Gene

genes like me logo Genes that share paralogs with RNF126: view

Variants for RNF126 Gene

Sequence variations from dbSNP and Humsavar for RNF126 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs2285751 - 651,852(+) GTCCA(C/T)GTGCT reference, missense
rs757331 -- 647,251(+) TGACC(A/G)AAGCG downstream-variant-500B
rs7257070 -- 647,486(+) CCTTT(C/T)CCTGA downstream-variant-500B
rs12976320 -- 649,239(+) GCGCT(C/G)CTGAG intron-variant
rs8100039 -- 659,469(+) GCAGG(C/G)AGAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNF126 Gene

Variant ID Type Subtype PubMed ID
nsv428360 CNV Gain 18775914
nsv910102 CNV Loss 21882294
nsv910109 CNV Loss 21882294
nsv470101 CNV Loss 18288195
dgv3508n71 CNV Loss 21882294
dgv3510n71 CNV Loss 21882294
dgv3511n71 CNV Loss 21882294
dgv3513n71 CNV Loss 21882294
dgv3514n71 CNV Gain 21882294
dgv3515n71 CNV Loss 21882294
dgv3516n71 CNV Loss 21882294
dgv3519n71 CNV Gain+Loss 21882294
dgv3525n71 CNV Loss 21882294
dgv3526n71 CNV Loss 21882294
dgv3528n71 CNV Loss 21882294
dgv3530n71 CNV Gain 21882294
dgv3531n71 CNV Loss 21882294
nsv910224 CNV Loss 21882294
dgv3532n71 CNV Gain 21882294
dgv3533n71 CNV Gain+Loss 21882294
dgv3534n71 CNV Loss 21882294
dgv3536n71 CNV Gain 21882294
dgv3537n71 CNV Loss 21882294
nsv910246 CNV Gain+Loss 21882294
dgv3538n71 CNV Gain 21882294
dgv3539n71 CNV Loss 21882294
nsv910252 CNV Loss 21882294
nsv910253 CNV Loss 21882294
nsv910254 CNV Loss 21882294
dgv3540n71 CNV Loss 21882294

Variation tolerance for RNF126 Gene

Gene Damage Index Score: 4.37; 63.43% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RNF126 Gene

Disorders for RNF126 Gene

Relevant External Links for RNF126

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RNF126

No disorders were found for RNF126 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF126 Gene

Publications for RNF126 Gene

  1. Cytosolic quality control of mislocalized proteins requires RNF126 recruitment to Bag6. (PMID: 24981174) Rodrigo-Brenni M.C. … Hegde R.S. (Mol. Cell 2014) 3 4 67
  2. RNF126 promotes homologous recombination via regulation of E2F1-mediated BRCA1 expression. (PMID: 26234677) Wang Y. … Zhang J. (Oncogene 2016) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. The ubiquitin ligase RNF126 regulates the retrograde sorting of the cation-independent mannose 6-phosphate receptor. (PMID: 24275455) Smith C.J. … McGlade C.J. (Exp. Cell Res. 2014) 3

Products for RNF126 Gene

Sources for RNF126 Gene

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