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RNF126 Gene

protein-coding   GIFtS: 50
GCID: GC19M000647

Ring Finger Protein 126

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ring Finger Protein 1261 2 3
E3 Ubiquitin-Protein Ligase RNF1262
EC 6.3.2.-3

External Ids:    HGNC: 211511   Entrez Gene: 556582   Ensembl: ENSG000000704237   OMIM: 6151775   UniProtKB: Q9BV683   

Export aliases for RNF126 gene to outside databases

Previous GC identifers: GC19M000587 GC19M000599 GC19M000600 GC19M000601 GC19M000602 GC19M000418


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RNF126 Gene:
The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally
distinct proteins and known to be involved in protein-protein and protein-DNA interactions. (provided by RefSeq,
Jul 2008)

GeneCards Summary for RNF126 Gene:
RNF126 (ring finger protein 126) is a protein-coding gene. Diseases associated with RNF126 include hemochromatosis. GO annotations related to this gene include ligase activity. An important paralog of this gene is PJA2.

UniProtKB/Swiss-Prot: RN126_HUMAN, Q9BV68
Function: E3 ubiquitin-protein ligase. By ubiquitinating CDKN1A/p21 and targeting it for proteasomal degradation,
may promote cell proliferation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RNF126 gene promoter:
         Max1   Lmo2   MyoD   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNF126 promoter sequence
   Search Chromatin IP Primers for RNF126

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNF126


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

RNF126 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF126 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M000647:  view genomic region     (about GC identifiers)

Start:
647,526 bp from pter      End:
663,277 bp from pter
Size:
15,752 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RN126_HUMAN, Q9BV68 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase RNF126  
Size: 326 amino acids; 35585 Da
Secondary accessions: Q9NWX1
Alternative splicing: 2 isoforms:  Q9BV68-1   Q9BV68-2   

Explore the universe of human proteins at neXtProt for RNF126: NX_Q9BV68

Explore proteomics data for RNF126 at MOPED

Post-translational modifications: 

  • Auto-ubiquitinated1
  • Ubiquitination2 at Lys233
  • Modification sites at PhosphoSitePlus

  • See RNF126 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_919442.1  
    ENSEMBL proteins: 
     ENSP00000292363   ENSP00000475833   ENSP00000465274   ENSP00000464945   ENSP00000475360  
     ENSP00000475214  

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    Cloud-Clone Corp. CLIAs for RNF126


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers

    2 InterPro protein domains:
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q9BV68

    ProtoNet protein and cluster: Q9BV68

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: RN126_HUMAN, Q9BV68
    Similarity: Contains 1 RING-type zinc finger


    RNF126 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RN126_HUMAN, Q9BV68
    Function: E3 ubiquitin-protein ligase. By ubiquitinating CDKN1A/p21 and targeting it for proteasomal degradation,
    may promote cell proliferation

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16189514
    GO:0008270zinc ion binding IEA--
    GO:0016874ligase activity IEA--
    GO:0046872metal ion binding ----
         
    RNF126 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RNF126
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    miRNA
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    miRTarBase miRNAs that target RNF126:
    hsa-mir-877-5p (MIRT037228)

    Block miRNA regulation of human, mouse, rat RNF126 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RNF126 (see all 10):
    hsa-miR-3163 hsa-miR-607 hsa-miR-4282 hsa-miR-340 hsa-miR-466 hsa-miR-138 hsa-miR-205* hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmidRNF126 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RNF126

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RN126_HUMAN, Q9BV68: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    extracellular1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    RNF126 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including RNF126: 
              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for RNF126

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RNF126 (Q9BV681, 2, 3 ENSP000002923634) via UniProtKB, MINT, STRING, and/or I2D (see all 51)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000096155P463792, 3MINT-62619 MINT-62717 MINT-62793 I2D: score=3 
    ENSG00000227761P463792, 3MINT-62619 MINT-62717 MINT-62793 I2D: score=3 
    ENSG00000228760P463792, 3MINT-62619 MINT-62717 MINT-62793 I2D: score=3 
    ENSG00000229524P463792, 3MINT-62619 MINT-62717 MINT-62793 I2D: score=3 
    ENSG00000233348P463792, 3MINT-62619 MINT-62717 MINT-62793 I2D: score=3 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RNF126 (RN126)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RNF126 gene (2 alternative transcripts): 
    NM_194460.2  NM_017876.3  

    Unigene Cluster for RNF126:

    Ring finger protein 126
    Hs.69554  [show with all ESTs]
    Unigene Representative Sequence: BM558798
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000292363(uc010drs.3) ENST00000586749 ENST00000590885 ENST00000591452
    ENST00000605891 ENST00000592418 ENST00000589762 ENST00000591394 ENST00000591356
    ENST00000606702 ENST00000606896 ENST00000592626
    miRNA
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    Block miRNA regulation of human, mouse, rat RNF126 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RNF126 (see all 10):
    hsa-miR-3163 hsa-miR-607 hsa-miR-4282 hsa-miR-340 hsa-miR-466 hsa-miR-138 hsa-miR-205* hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmidRNF126 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for RNF126
    Predesigned siRNA for gene silencing in human, mouse, rat RNF126
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RNF126 (NM_194460)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNF126
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF126
    Primer
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    OriGene qPCR primer pairs and template standards for RNF126
    OriGene qSTAR qPCR primer pairs in human, mouse for RNF126
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat RNF126
      QuantiTect SYBR Green Assays in human, mouse, rat RNF126
      QuantiFast Probe-based Assays in human, mouse, rat RNF126

    Additional mRNA sequence: 

    AK000559.1 AK289616.1 BC025374.1 

    14 DOTS entries:

    DT.40314801  DT.75176466  DT.40115024  DT.100824363  DT.92467118  DT.95290025  DT.121501171  DT.100824356 
    DT.121501181  DT.100800094  DT.100824355  DT.102836526  DT.97810505  DT.99978816 

    Selected AceView cDNA sequences (see all 279):

    CD244112 BF222861 AI989787 CK904690 AK000559 BU634538 BI836948 BF056455 
    AA804361 NM_194460 BQ880935 AI738625 BE407377 CD367698 BG060117 BU684694 
    AW270054 BI826574 BM782831 BU153909 BX338693 CA392330 BM974683 BM765227 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RNF126 (see all 13)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11a · 11b · 11c ·
    SP1:        -     -           -           -                       -     -     -     -                 -     -     -                                             
    SP2:        -     -           -           -                                   -     -                 -     -     -                                             
    SP3:                          -                                               -     -                 -     -     -                                             
    SP4:                          -           -     -     -                       -     -                 -     -     -                                             
    SP5:                          -           -                                   -     -                 -     -     -                                             

    ExUns: 11d · 11e
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for RNF126

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RNF126 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGATGACCA
    RNF126 Expression
    About this image

    RNF126 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RNF126 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.69554

    UniProtKB/Swiss-Prot: RN126_HUMAN, Q9BV68
    Tissue specificity: Highly expressed in liver and testis

        Pathway & Disease-focused RT2 Profiler PCR Array including RNF126: 
              Ubiquitin Ligases in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat RNF126
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF126

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RNF126 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnf1261 , 5 ring finger protein 1261, 5 87.14(n)1
    94.21(a)1
      10 (39.72 cM)5
    702941  NM_144528.31  NP_653111.11 
     797585155 
    chicken
    (Gallus gallus)
    Aves RNF1261 ring finger protein 126 75.38(n)
    82.58(a)
      420085  NM_001006338.2  NP_001006338.2 
    lizard
    (Anolis carolinensis)
    Reptilia RNF1266
    ring finger protein 126
    72(a)
    1 ↔ 1
    GL345020.1(2697-13487)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC690962 hypothetical protein MGC69096 71.82(n)    BC056088.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rnf1261 ring finger protein 126 70.04(n)
    77.12(a)
      100009648  NM_001083017.1  NP_001076486.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG119821 CG11982 49.36(n)
    35.11(a)
      41080  NM_141602.4  NP_649859.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y54E10BR.36
    Protein Y54E10BR.3 (Y54E10BR.3) mRNA, complete cds...
    24(a)
    1 → many
    I(3021649-3028384) WBGene00021842
    rice
    (Oryza sativa)
    Liliopsida AK068144.12   -- 75.5(n)    AK068144.1 


    ENSEMBL Gene Tree for RNF126 (if available)
    TreeFam Gene Tree for RNF126 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RNF126 gene
    PJA22  RNF1812  RNF1152  PJA12  
    2 SIMAP similar genes for RNF126 using alignment to 6 protein entries:     RN126_HUMAN (see all proteins):
    RNF115    RNF181

    RNF126 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for RNF126
    PGOHUM00000262988


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RNF126 (see all 565)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs20744601,2
    C,F,H--577138(+) TTAGCC/TGTCTC 1 -- int126Minor allele frequency- T:0.08EA NS NA WA CSA 3623
    rs1871188221,2
    --577211(+) CCCGGA/CCCCCT 1 -- int10--------
    rs7573311,2
    C,F,A,H--577350(+) TGACCG/AAAGCG 1 -- int122Minor allele frequency- A:0.29EA NA NS 2516
    rs621342731,2
    F--577544(+) AGGACC/TGGACT 1 -- int12Minor allele frequency- T:0.04NA 122
    rs563762391,2
    C--577554(+) TCTGCA/GGAGCC 1 -- int13Minor allele frequency- G:0.08NA EA 242
    rs1181078041,2
    C,F--577561(+) AGCCCG/AACCAG 1 -- int11Minor allele frequency- A:0.04NA 120
    rs72570701,2
    C,F--577585(+) CCTTTT/CCCTGA 1 -- int17Minor allele frequency- C:0.35NA WA EA 366
    rs1929658451,2
    --577744(+) CCGAGC/TCCCCC 1 -- ut310--------
    rs1161250901,2
    C,F--577764(+) TCGTGG/AAGGCG 1 -- ut311Minor allele frequency- A:0.06WA 118
    rs1147427431,2
    C,F--577810(+) CTGGCG/AGCACC 1 -- ut311Minor allele frequency- A:0.07WA 118

    HapMap Linkage Disequilibrium report for RNF126 (647526 - 663277 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for RNF126 (see all 30):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv470101CNV Loss18288195
    dgv3526n71CNV Loss21882294
    dgv3525n71CNV Loss21882294
    dgv3528n71CNV Loss21882294
    dgv3515n71CNV Loss21882294
    nsv910252CNV Loss21882294
    nsv910254CNV Loss21882294
    dgv3539n71CNV Loss21882294
    nsv910109CNV Loss21882294
    nsv910102CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 615177    OMIM disorders: --

    1 disease for RNF126:    
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    hemochromatosis


    RNF126 for disorders           About GeneDecksing


    Export disorders for RNF126 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RNF126 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with RNF126)
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    world of online information

    1. E3 ubiquitin ligase RNF126 promotes cancer cell proliferation by targeting the tumor suppressor p21 for ubiquitin-mediated degradation. (PubMed id 23026136)1, 2 Zhi X.... Chen C. (Cancer Res. 2013)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The ubiquitin ligase RNF126 regulates the retrograde sorting of the cation-independent mannose 6-phosphate receptor. (PubMed id 24275455)1 Smith C.J. and McGlade C.J. (Exp. Cell Res. 2014)
    5. Solubility-based genetic screen identifies RING finger protein 126 as an E3 ligase for activation-induced cytidine deaminase. (PubMed id 23277564)1 Delker R.K....Papavasiliou F.N. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    6. VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (PLoS ONE 2013)
    7. The E3 ubiquitin ligases RNF126 and Rabring7 regulate endosomal sorting of the epidermal growth factor receptor. (PubMed id 23418353)1 Smith C.J....McGlade C.J. (J. Cell. Sci. 2013)
    8. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PubMed id 23349634)1 Cloutier P.... Coulombe B. (PLoS Genet. 2013)
    9. Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)1 Woodsmith J....Sanderson C.M. (amp 2012)
    10. SGTA recognizes a noncanonical ubiquitin-like domain in the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degradation. (PubMed id 23246001)1 Xu Y....Ye Y. (Cell Rep 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55658 HGNC: 21151 AceView: RNF126 Ensembl:ENSG00000070423 euGenes: HUgn55658
    ECgene: RNF126 H-InvDB: RNF126

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RNF126 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RNF126 gene:
    Search GeneIP for patents involving RNF126

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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