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RNF125 Gene

protein-coding   GIFtS: 55
GCID: GC18P029598

Ring Finger Protein 125, E3 Ubiquitin Protein Ligase

(Previous name: ring finger protein 125)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ring Finger Protein 125, E3 Ubiquitin Protein Ligase1 2     TRAC12 5
RING Finger Protein 1251 3     E3 Ubiquitin-Protein Ligase RNF1252
TRAC-12 3     T-Cell Ring Protein Identified In Activation Screen2
T-Cell RING Activation Protein 12 3     EC 6.3.2.-3

External Ids:    HGNC: 211501   Entrez Gene: 549412   Ensembl: ENSG000001016957   OMIM: 6104325   UniProtKB: Q96EQ83   

Export aliases for RNF125 gene to outside databases

Previous GC identifers: GC18P029486 GC18P027850 GC18P027852 GC18P026455


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RNF125 Gene:
This gene encodes a novel E3 ubiquitin ligase that contains a RING finger domain in the N-terminus and three
zinc-binding and one ubiquitin-interacting motif in the C-terminus. As a result of myristoylation, this protein
associates with membranes and is primarily localized to intracellular membrane systems. The encoded protein may
function as a positive regulator in the T-cell receptor signaling pathway. (provided by RefSeq, Mar 2012)

GeneCards Summary for RNF125 Gene:
RNF125 (ring finger protein 125, E3 ubiquitin protein ligase) is a protein-coding gene. GO annotations related to this gene include ubiquitin-protein ligase activity. An important paralog of this gene is RNF166.

UniProtKB/Swiss-Prot: RN125_HUMAN, Q96EQ8
Function: E3 ubiquitin-protein ligase that acts as a positive regulator of T-cell activation. E3 ligase proteins
mediate ubiquitination and subsequent proteasomal degradation of target proteins

Gene Wiki entry for RNF125 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000018.9  NC_018929.2  NT_010966.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the RNF125 gene promoter:
         USF1   USF-1:USF-2   RelA   NF-kappaB   SRY   USF-1   IRF-7A   ZIC2/Zic2   NF-kappaB1   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNF125 promoter sequence
   Search Chromatin IP Primers for RNF125

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNF125


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q12.1   Ensembl cytogenetic band:  18q12.1   HGNC cytogenetic band: 18q12.1

RNF125 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF125 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P029598:  view genomic region     (about GC identifiers)

Start:
29,598,335 bp from pter      End:
29,653,176 bp from pter
Size:
54,842 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RN125_HUMAN, Q96EQ8 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase RNF125  
Size: 232 amino acids; 26454 Da
Secondary accessions: Q9NX39

Explore the universe of human proteins at neXtProt for RNF125: NX_Q96EQ8

Explore proteomics data for RNF125 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys69, Lys91
  • Modification sites at PhosphoSitePlus

  • See RNF125 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060301.2  
    ENSEMBL proteins: 
     ENSP00000217740   ENSP00000463935  
    Reactome Protein details: Q96EQ8

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    antibodies-online peptides for RNF125

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers

    5 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR008598 Di19_Zn_binding
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q96EQ8

    ProtoNet protein and cluster: Q96EQ8

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: RN125_HUMAN, Q96EQ8
    Similarity: Contains 1 RING-type zinc finger


    Find genes that share domains with RNF125           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RN125_HUMAN, Q96EQ8
    Function: E3 ubiquitin-protein ligase that acts as a positive regulator of T-cell activation. E3 ligase proteins
    mediate ubiquitination and subsequent proteasomal degradation of target proteins

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IEA--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0046872metal ion binding ----
         
    Find genes that share ontologies with RNF125           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for RNF125

    miRNA
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    miRTarBase miRNAs that target RNF125:
    hsa-mir-320a (MIRT044723), hsa-mir-26b-5p (MIRT028944), hsa-mir-151a-3p (MIRT043614)

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    hsa-miR-142-5p hsa-miR-219-1-3p hsa-miR-642a hsa-miR-4328 hsa-miR-15a hsa-miR-938 hsa-miR-16-1* hsa-miR-3653
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol1
    golgi apparatus1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RNF125 About    
    See pathways by source

    SuperPathContained pathways About
    1RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways0.47
    Negative regulators of RIG-I/MDA5 signaling0.42
    RIG-I-like receptor signaling pathway0.47


    Find genes that share SuperPaths with RNF125           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for RNF125
        Negative regulators of RIG-I/MDA5 signaling


    1 Kegg Pathway  (Kegg details for RNF125):
        RIG-I-like receptor signaling pathway

    UniProtKB/Swiss-Prot: RN125_HUMAN, Q96EQ8
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Array including RNF125: 

              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for RNF125

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    Selected Interacting proteins for RNF125 (Q96EQ83 ENSP000002177404) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE2L6O149333, ENSP000002871564I2D: score=3 STRING: ENSP00000287156
    UBE2D2P628373, ENSP000003817174I2D: score=2 STRING: ENSP00000381717
    UBE2D3P610773, ENSP000003497224I2D: score=2 STRING: ENSP00000349722
    UBE2NP610883, ENSP000003161764I2D: score=2 STRING: ENSP00000316176
    UBE2UQ5VVX93, ENSP000003601164I2D: score=2 STRING: ENSP00000360116
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0032480negative regulation of type I interferon production TAS--
    GO:0045087innate immune response TAS--

    Find genes that share ontologies with RNF125           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for RNF125 (RN125)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RNF125 gene: 
    NM_017831.3  

    Unigene Cluster for RNF125:

    Ring finger protein 125, E3 ubiquitin protein ligase
    Hs.633703  [show with all ESTs]
    Unigene Representative Sequence: NM_017831
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000217740(uc002kxf.1) ENST00000580209 ENST00000583384 ENST00000583814
    ENST00000580863
    miRNA
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    hsa-miR-142-5p hsa-miR-219-1-3p hsa-miR-642a hsa-miR-4328 hsa-miR-15a hsa-miR-938 hsa-miR-16-1* hsa-miR-3653
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    Additional mRNA sequence: 

    AK000463.1 AK027134.1 AK225518.1 BC012021.1 

    3 DOTS entries:

    DT.91795393  DT.91688233  DT.91659035 

    17 AceView cDNA sequences:

    NM_017831 BE302781 BX283264 BG387827 AK000463 BE384400 BQ225812 BI666910 
    BC012021 BU500546 AV760621 AL713489 BM469263 BQ879004 AV762059 BV185326 
    CD684818 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for RNF125    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b
    SP1:                          -                       -               
    SP2:                          -                       -               
    SP3:                          -     -                                 
    SP4:                                            -     -               


    ECgene alternative splicing isoforms for RNF125

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RNF125 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTATTCTTCT
    RNF125 Expression
    About this image


    RNF125 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Smooth Muscle (Muscoskeletal System)
             Juxtaglomerular Cells Afferent Arteriole
     
     Ovary (Reproductive System)
             Cumulus Cells Antral Follicle
     
     Inner Cell Mass (Early Embryonic Tissues)
             C2a
     
     Kidney (Urinary System)
             Juxtaglomerular Cells Afferent Arteriole
    RNF125 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RNF125 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.633703

    UniProtKB/Swiss-Prot: RN125_HUMAN, Q96EQ8
    Tissue specificity: Predominantly expressed in lymphoid tissues, including bone marrow, spleen and thymus. Also
    weakly expressed in other tissues. Predominant in the CD4+ and CD8+ T-cells, suggesting that it is preferentially
    confined to T-cells

        Pathway & Disease-focused RT2 Profiler PCR Array including RNF125: 
              Ubiquitin Ligases in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for RNF125 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnf1255 ring finger protein 125   --   18 (11.67 cM) 20944625 
    lizard
    (Anolis carolinensis)
    Reptilia RNF1256
    ring finger protein 125, E3 ubiquitin protein liga...
    63(a)
    1 ↔ 1
    GL343207.1(3443845-3451871)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia rnf1251 ring finger protein 125, E3 ubiquitin protein ligase 60.03(n)
    54.3(a)
      100493643  XM_002934120.2  XP_002934166.1 
    zebrafish
    (Danio rerio)
    Actinopterygii RNF1256
    ring finger protein 125, E3 ubiquitin protein liga...
    14(a)
    1 ↔ 1
    20(6582578-6595777) ENSDARG00000081322


    ENSEMBL Gene Tree for RNF125 (if available)
    TreeFam Gene Tree for RNF125 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RNF125 gene
    RNF1662  RNF1382  RNF1142  
    1 SIMAP similar gene for RNF125 using alignment to 2 protein entries:     RN125_HUMAN (see all proteins):
    RNF114

    Find genes that share paralogs with RNF125           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RNF125 (see all 1163)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1932883461,2
    --29596509(+) GAAGCA/GGATAT 1 -- us2k10--------
    rs350021851,2
    C--29596601(+) TATTT-/C/CC  
            
    CCCCC
    1 -- us2k10--------
    rs1838342181,2
    --29596607(+) CCCCCC/GCCCCA 1 -- us2k10--------
    rs741713631,2
    C--29596609(-) GGTGGTGG/-GGGGG 1 -- cds11Minor allele frequency- -:0.50NA 2
    rs1487486581,2
    --29596901(+) TTGTTA/GTTTGT 1 -- us2k10--------
    rs1178229431,2
    F--29596923(+) AGTCTC/TGCTCT 1 -- us2k11Minor allele frequency- T:0.01NA 120
    rs47993221,2
    C,F,A,H--29596992(+) ggtgcA/Gagtgg 1 -- us2k18Minor allele frequency- G:0.47EA NS NA WA CSA 272
    rs47993231,2
    C,F,A--29597035(+) ctacaA/Cgcatg 1 -- us2k13Minor allele frequency- C:0.33NA WA CSA 6
    rs1401245151,2
    --29597115(+) AGAGAC/TGGGGT 1 -- us2k10--------
    rs1455489841,2
    --29597129(+) ACTATA/GTTGGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RNF125 (29598335 - 29653176 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for RNF125:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv524199CNV Loss19592680
    nsv909520CNV Gain21882294
    dgv3404n71CNV Gain21882294
    dgv1021e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610432    OMIM disorders: --


    Find genes that share disorders with RNF125           About GenesLikeMe

    Genetic Association Database (GAD): RNF125

    Export disorders for RNF125 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RNF125 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with RNF125)
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    1. A novel E3 ubiquitin ligase TRAC-1 positively regulates T cell activation. (PubMed id 15843525)1, 2 Zhao H.... Masuda E.S. (J. Immunol. 2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Systematic identification of regulatory proteins critical for T-cell activation. (PubMed id 12974981)1, 2 Chu P.... Liao X.C. (J. Biol. 2003)
    5. T-cell regulator RNF125/TRAC-1 belongs to a novel family of ubiquitin ligases with zinc fingers and a ubiquitin-binding domain. (PubMed id 17990982)1, 9 Giannini A.L....Bijlmakers M.J. (Biochem. J. 2008)
    6. Human bocavirus VP2 upregulates IFN-I^ pathway by inhibiting ring finger protein 125-mediated ubiquitination of retinoic acid-inducible gene-I. (PubMed id 23772026)1 Luo H....Wang H. (J. Immunol. 2013)
    7. Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)1 Woodsmith J....Sanderson C.M. (amp 2012)
    8. The global gene-expression profiles of U-937 human macrophages treated with Tat peptide and Tat-FITC conjugate. (PubMed id 22632162)1 Lin C.W....Jan M.S. (J Drug Target 2012)
    9. Direct and indirect control of mitogen-activated protein kinase pathway-associated components, BRAP/IMP E3 ubiquitin ligase and CRAF/RAF1 kinase, by the deubiquitylating enzyme USP15. (PubMed id 23105109)1 Hayes S.D....UrbAc S. (J. Biol. Chem. 2012)
    10. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54941 HGNC: 21150 AceView: RNF125 Ensembl:ENSG00000101695 euGenes: HUgn54941
    ECgene: RNF125 Kegg: 54941 H-InvDB: RNF125

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RNF125 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RNF125 gene:
    Search GeneIP for patents involving RNF125

    GeneCards and IP:
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