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Aliases for RNF123 Gene

Aliases for RNF123 Gene

  • Ring Finger Protein 123 2 3
  • Kip1 Ubiquitination-Promoting Complex Subunit 1 2 3
  • Kip1 Ubiquitination-Promoting Complex Protein 1 3 4
  • RING-Type E3 Ubiquitin Transferase RNF123 3 4
  • RING Finger Protein 123 4 5
  • KPC1 3 4
  • E3 Ubiquitin-Protein Ligase RNF123 3
  • EC 4
  • FP1477 3

External Ids for RNF123 Gene

Previous GeneCards Identifiers for RNF123 Gene

  • GC03P049581
  • GC03P049685
  • GC03P049701
  • GC03P049726

Summaries for RNF123 Gene

Entrez Gene Summary for RNF123 Gene

  • The protein encoded by this gene contains a C-terminal RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions, and an N-terminal SPRY domain. This protein displays E3 ubiquitin ligase activity toward the cyclin-dependent kinase inhibitor 1B which is also known as p27 or KIP1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

GeneCards Summary for RNF123 Gene

RNF123 (Ring Finger Protein 123) is a Protein Coding gene. Among its related pathways are Deubiquitination and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ligase activity. An important paralog of this gene is RSPRY1.

UniProtKB/Swiss-Prot for RNF123 Gene

  • Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle.

Gene Wiki entry for RNF123 Gene

Additional gene information for RNF123 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF123 Gene

Genomics for RNF123 Gene

Regulatory Elements for RNF123 Gene

Enhancers for RNF123 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H050297 1.4 Ensembl ENCODE 4.3 +611.8 611773 6.5 HDGF PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 HYAL3 SEMA3F-AS1 RBM5 TMEM115 CYB561D2 HYAL1 AMT NAT6 DAG1 RNF123
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RNF123 on UCSC Golden Path with GeneCards custom track

Promoters for RNF123 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000152257 657 1201 HDGF MLX ARNT ARID4B SIN3A ZNF2 ZNF143 ZNF207 SP3 MXD4

Genomic Locations for RNF123 Gene

Genomic Locations for RNF123 Gene
32,387 bases
Plus strand

Genomic View for RNF123 Gene

Genes around RNF123 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF123 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF123 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF123 Gene

Proteins for RNF123 Gene

  • Protein details for RNF123 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    E3 ubiquitin-protein ligase RNF123
    Protein Accession:
    Secondary Accessions:
    • A1L4Q3
    • A6NLS5
    • Q5I022
    • Q6PFW4
    • Q71RH0
    • Q8IW18
    • Q9H0M8
    • Q9H5L8
    • Q9H9T2

    Protein attributes for RNF123 Gene

    1314 amino acids
    Molecular mass:
    148515 Da
    Quaternary structure:
    • Component of the KPC complex composed of RNF123/KPC1 and UBAC1/KPC2. Interacts with UBAC1 and CDKN1B via its N-terminal domain.
    • Sequence=BAB14139.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15607.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RNF123 Gene

    Alternative splice isoforms for RNF123 Gene


neXtProt entry for RNF123 Gene

Post-translational modifications for RNF123 Gene

  • Ubiquitinated, leading to its degradation. Deubiquitinated by USP19, thereby stimulating CDKN1B ubiquitin-dependent degradation.
  • Ubiquitination at Lys33, Lys467, Lys530, Lys704, Lys806, Lys814, isoforms=2906, and isoforms=21286
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RNF123 Gene

Domains & Families for RNF123 Gene

Gene Families for RNF123 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RNF123 Gene

Suggested Antigen Peptide Sequences for RNF123 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RNF123: view

No data available for UniProtKB/Swiss-Prot for RNF123 Gene

Function for RNF123 Gene

Molecular function for RNF123 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle.

Enzyme Numbers (IUBMB) for RNF123 Gene

Phenotypes From GWAS Catalog for RNF123 Gene

Gene Ontology (GO) - Molecular Function for RNF123 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RNF123: view
genes like me logo Genes that share phenotypes with RNF123: view

miRNA for RNF123 Gene

miRTarBase miRNAs that target RNF123

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNF123 Gene

Localization for RNF123 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF123 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNF123 gene
Compartment Confidence
cytosol 5
plasma membrane 3
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RNF123 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS,IDA --
genes like me logo Genes that share ontologies with RNF123: view

Pathways & Interactions for RNF123 Gene

genes like me logo Genes that share pathways with RNF123: view

UniProtKB/Swiss-Prot Q5XPI4-RN123_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for RNF123 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0016579 protein deubiquitination TAS --
genes like me logo Genes that share ontologies with RNF123: view

No data available for SIGNOR curated interactions for RNF123 Gene

Drugs & Compounds for RNF123 Gene

No Compound Related Data Available

Transcripts for RNF123 Gene

Unigene Clusters for RNF123 Gene

Ring finger protein 123:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF123 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b · 20c ^
SP4: -
SP6: -
SP7: -

ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31
SP7: -

Relevant External Links for RNF123 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNF123 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNF123 Gene

mRNA differential expression in normal tissues according to GTEx for RNF123 Gene

This gene is overexpressed in Muscle - Skeletal (x7.4).

Protein differential expression in normal tissues from HIPED for RNF123 Gene

This gene is overexpressed in Lymph node (10.1), Heart (7.2), and Tonsil (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RNF123 Gene

Protein tissue co-expression partners for RNF123 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RNF123 Gene:


SOURCE GeneReport for Unigene cluster for RNF123 Gene:


Evidence on tissue expression from TISSUES for RNF123 Gene

  • Nervous system(4.8)
  • Lung(4.2)
  • Eye(4.1)
  • Muscle(2.6)
genes like me logo Genes that share expression patterns with RNF123: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNF123 Gene

Orthologs for RNF123 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RNF123 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RNF123 33
  • 98.16 (n)
(Canis familiaris)
Mammalia RNF123 33 34
  • 90.84 (n)
(Bos Taurus)
Mammalia RNF123 33 34
  • 89.26 (n)
(Mus musculus)
Mammalia Rnf123 33 16 34
  • 89.09 (n)
(Rattus norvegicus)
Mammalia Rnf123 33
  • 88.59 (n)
(Monodelphis domestica)
Mammalia RNF123 34
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia RNF123 34
  • 72 (a)
(Gallus gallus)
Aves RNF123 33 34
  • 76.09 (n)
(Anolis carolinensis)
Reptilia RNF123 34
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf123 33
  • 71.3 (n)
Str.7038 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.10089 33
(Danio rerio)
Actinopterygii rnf123 34
  • 78 (a)
LOC101884269 33
  • 72.88 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG6752 34 33
  • 47.34 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009295 33
  • 26.27 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons RKP 33
  • 41.17 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 11 (a)
Species where no ortholog for RNF123 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF123 Gene

Gene Tree for RNF123 (if available)
Gene Tree for RNF123 (if available)

Paralogs for RNF123 Gene

Paralogs for RNF123 Gene

genes like me logo Genes that share paralogs with RNF123: view

Variants for RNF123 Gene

Sequence variations from dbSNP and Humsavar for RNF123 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs199922550 Pathogenic 49,721,847(+) TATGA(C/T)GTCCT downstream-variant-500B, reference, missense
rs397509422 Pathogenic 49,721,835(+) CTCAT(C/T)ATTAA downstream-variant-500B, reference, missense
rs886039910 Likely pathogenic 49,721,964(-) AGTGG(A/G)TAAGC downstream-variant-500B, reference, missense, splice-donor-variant
rs184127567 Uncertain significance 49,721,787(+) CTCGC(C/T)AATAG downstream-variant-500B, upstream-variant-2KB, reference, missense
rs747845961 Uncertain significance 49,721,897(+) GAGGA(C/T)AGGCC intron-variant, downstream-variant-500B, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for RNF123 Gene

Variant ID Type Subtype PubMed ID
esv28815 CNV gain+loss 19812545
nsv1118699 CNV duplication 24896259
nsv1141429 CNV duplication 24896259
nsv1148681 CNV duplication 26484159
nsv482082 CNV gain 20164927
nsv508217 CNV deletion 20534489
nsv820990 CNV duplication 20802225
nsv822077 CNV gain 20364138
nsv979829 CNV duplication 23825009

Variation tolerance for RNF123 Gene

Residual Variation Intolerance Score: 22.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.65; 72.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNF123 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF123 Gene

Disorders for RNF123 Gene

Relevant External Links for RNF123

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RNF123 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF123 Gene

Publications for RNF123 Gene

  1. Role of the UBL-UBA protein KPC2 in degradation of p27 at G1 phase of the cell cycle. (PMID: 16227581) Hara T … Nakayama KI (Molecular and cellular biology 2005) 3 4 22 60
  2. Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase. (PMID: 15531880) Kamura T … Nakayama KI (Nature cell biology 2004) 2 3 4 60
  3. Association analysis of 3p21 with Crohn's disease in a New Zealand population. (PMID: 20307617) Morgan AR … Ferguson LR (Human immunology 2010) 3 45 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for RNF123 Gene

Sources for RNF123 Gene

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