Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RNF123 Gene

Aliases for RNF123 Gene

  • Ring Finger Protein 123 2 3
  • Kip1 Ubiquitination-Promoting Complex Protein 1 3 4
  • RING Finger Protein 123 4 5
  • KPC1 3 4
  • EC 6.3.2.- 4
  • FP1477 3

External Ids for RNF123 Gene

Previous GeneCards Identifiers for RNF123 Gene

  • GC03P049581
  • GC03P049685
  • GC03P049701
  • GC03P049726

Summaries for RNF123 Gene

Entrez Gene Summary for RNF123 Gene

  • The protein encoded by this gene contains a C-terminal RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions, and an N-terminal SPRY domain. This protein displays E3 ubiquitin ligase activity toward the cyclin-dependent kinase inhibitor 1B which is also known as p27 or KIP1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

GeneCards Summary for RNF123 Gene

RNF123 (Ring Finger Protein 123) is a Protein Coding gene. Among its related pathways are Antigen processing- Ubiquitination and Proteasome degradation and Immune System. GO annotations related to this gene include ligase activity. An important paralog of this gene is RSPRY1.

UniProtKB/Swiss-Prot for RNF123 Gene

  • Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle.

Gene Wiki entry for RNF123 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF123 Gene

Genomics for RNF123 Gene

Regulatory Elements for RNF123 Gene

Enhancers for RNF123 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RNF123 on UCSC Golden Path with GeneCards custom track

Promoters for RNF123 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RNF123 on UCSC Golden Path with GeneCards custom track

Genomic Location for RNF123 Gene

49,689,143 bp from pter
49,721,529 bp from pter
32,387 bases
Plus strand

Genomic View for RNF123 Gene

Genes around RNF123 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF123 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF123 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF123 Gene

Proteins for RNF123 Gene

  • Protein details for RNF123 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    E3 ubiquitin-protein ligase RNF123
    Protein Accession:
    Secondary Accessions:
    • A1L4Q3
    • A6NLS5
    • Q5I022
    • Q6PFW4
    • Q71RH0
    • Q8IW18
    • Q9H0M8
    • Q9H5L8
    • Q9H9T2

    Protein attributes for RNF123 Gene

    1314 amino acids
    Molecular mass:
    148515 Da
    Quaternary structure:
    • Component of the KPC complex composed of RNF123/KPC1 and UBAC1/KPC2. Interacts with UBAC1 and CDKN1B via its N-terminal domain.
    • Sequence=BAB14139.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15607.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RNF123 Gene

    Alternative splice isoforms for RNF123 Gene


neXtProt entry for RNF123 Gene

Proteomics data for RNF123 Gene at MOPED

Post-translational modifications for RNF123 Gene

  • Ubiquitinated, leading to its degradation. Deubiquitinated by USP19, thereby stimulating CDKN1B ubiquitin-dependent degradation (By similarity).
  • Ubiquitination at Lys 33, Lys 467, Lys 530, Lys 704, Lys 806, Lys 814, Lys 906, and Lys 1286
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RNF123 Gene

Domains & Families for RNF123 Gene

Gene Families for RNF123 Gene

Protein Domains for RNF123 Gene

Suggested Antigen Peptide Sequences for RNF123 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 B30.2/SPRY domain.
  • Contains 1 RING-type zinc finger.
  • Contains 1 B30.2/SPRY domain.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF123: view

Function for RNF123 Gene

Molecular function for RNF123 Gene

UniProtKB/Swiss-Prot Function:
Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle.

Enzyme Numbers (IUBMB) for RNF123 Gene

Gene Ontology (GO) - Molecular Function for RNF123 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with RNF123: view
genes like me logo Genes that share phenotypes with RNF123: view

Animal Model Products

miRNA for RNF123 Gene

miRTarBase miRNAs that target RNF123

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNF123 Gene

Localization for RNF123 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF123 Gene


Subcellular locations from

Jensen Localization Image for RNF123 Gene COMPARTMENTS Subcellular localization image for RNF123 gene
Compartment Confidence
plasma membrane 3
cytosol 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for RNF123 Gene

Pathways & Interactions for RNF123 Gene

genes like me logo Genes that share pathways with RNF123: view

UniProtKB/Swiss-Prot Q5XPI4-RN123_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for RNF123 Gene


No data available for SIGNOR curated interactions for RNF123 Gene

Drugs & Compounds for RNF123 Gene

No Compound Related Data Available

Transcripts for RNF123 Gene

Unigene Clusters for RNF123 Gene

Ring finger protein 123:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNF123 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b · 20c ^
SP4: -
SP6: -
SP7: -

ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31
SP7: -

Relevant External Links for RNF123 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNF123 Gene

mRNA expression in normal human tissues for RNF123 Gene

mRNA differential expression in normal tissues according to GTEx for RNF123 Gene

This gene is overexpressed in Muscle - Skeletal (x7.4).

Protein differential expression in normal tissues from HIPED for RNF123 Gene

This gene is overexpressed in Lymph node (10.1), Heart (7.2), and Tonsil (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RNF123 Gene

SOURCE GeneReport for Unigene cluster for RNF123 Gene Hs.553723

genes like me logo Genes that share expression patterns with RNF123: view

Protein tissue co-expression partners for RNF123 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for RNF123 Gene

Orthologs for RNF123 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RNF123 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RNF123 35
  • 89.26 (n)
  • 92.47 (a)
RNF123 36
  • 93 (a)
(Canis familiaris)
Mammalia RNF123 35
  • 90.84 (n)
  • 94.52 (a)
RNF123 36
  • 94 (a)
(Mus musculus)
Mammalia Rnf123 35
  • 89.09 (n)
  • 93.84 (a)
Rnf123 16
Rnf123 36
  • 94 (a)
(Pan troglodytes)
Mammalia RNF123 35
  • 98.16 (n)
  • 97.47 (a)
(Rattus norvegicus)
Mammalia Rnf123 35
  • 88.59 (n)
  • 93.67 (a)
(Monodelphis domestica)
Mammalia RNF123 36
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia RNF123 36
  • 72 (a)
(Gallus gallus)
Aves RNF123 35
  • 76.09 (n)
  • 80.15 (a)
RNF123 36
  • 79 (a)
(Anolis carolinensis)
Reptilia RNF123 36
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf123 35
  • 71.3 (n)
  • 78.48 (a)
Str.7038 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.10089 35
(Danio rerio)
Actinopterygii LOC101884269 35
  • 72.88 (n)
  • 78.9 (a)
rnf123 36
  • 78 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009295 35
  • 26.27 (n)
  • 6.95 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6752 35
  • 47.34 (n)
  • 34.59 (a)
CG6752 36
  • 23 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons RKP 35
  • 41.17 (n)
  • 30.36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 11 (a)
Species with no ortholog for RNF123:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF123 Gene

Gene Tree for RNF123 (if available)
Gene Tree for RNF123 (if available)

Paralogs for RNF123 Gene

Paralogs for RNF123 Gene

genes like me logo Genes that share paralogs with RNF123: view

Variants for RNF123 Gene

Sequence variations from dbSNP and Humsavar for RNF123 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_027561 -
rs35620248 - 49,700,521(+) GCTTC(A/G)GCTGT nc-transcript-variant, reference, missense
rs35726701 - 49,703,462(+) ATGGC(A/G)AGGTG nc-transcript-variant, reference, missense
rs34823813 - 49,712,543(+) TGATC(A/G)CACAG nc-transcript-variant, reference, missense
rs2291542 -- 49,714,152(-) TTGGC(A/G)TCCTC nc-transcript-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for RNF123 Gene

Variant ID Type Subtype PubMed ID
nsv508217 CNV Loss 20534489
nsv820990 CNV Duplication 20802225
esv28815 CNV Gain+Loss 19812545
nsv822077 CNV Gain 20364138
nsv482082 CNV Gain 20164927

Variation tolerance for RNF123 Gene

Residual Variation Intolerance Score: 22.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.65; 72.77% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RNF123 Gene

Disorders for RNF123 Gene

Relevant External Links for RNF123

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RNF123 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF123 Gene

Publications for RNF123 Gene

  1. Role of the UBL-UBA protein KPC2 in degradation of p27 at G1 phase of the cell cycle. (PMID: 16227581) Hara T. … Nakayama K. (Mol. Cell. Biol. 2005) 3 4 23 67
  2. KPC1-mediated ubiquitination and proteasomal processing of NF-I_B1 p105 to p50 restricts tumor growth. (PMID: 25860612) Kravtsova-Ivantsiv Y. … Ciechanover A. (Cell 2015) 3
  3. Biochemical and functional characterization of RNF213 (Mysterin) R4810K, a susceptibility mutation of Moyamoya disease, in angiogenesis in vitro and in vivo. (PMID: 26126547) Kobayashi H. … Koizumi A. (J. Am. Heart. Assoc. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for RNF123 Gene

Sources for RNF123 Gene