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Aliases for RNF123 Gene

Aliases for RNF123 Gene

  • Ring Finger Protein 123 2 3
  • KPC1 3 4 6
  • Kip1 Ubiquitination-Promoting Complex Protein 1 3 4
  • E3 Ubiquitin-Protein Ligase RNF123 3
  • RING Finger Protein 123 4
  • EC 6.3.2.- 4
  • FP1477 3

External Ids for RNF123 Gene

Previous GeneCards Identifiers for RNF123 Gene

  • GC03P049581
  • GC03P049685
  • GC03P049701
  • GC03P049726

Summaries for RNF123 Gene

Entrez Gene Summary for RNF123 Gene

  • The protein encoded by this gene contains a C-terminal RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions, and an N-terminal SPRY domain. This protein displays E3 ubiquitin ligase activity toward the cyclin-dependent kinase inhibitor 1B which is also known as p27 or KIP1. [provided by RefSeq, Feb 2012]

GeneCards Summary for RNF123 Gene

RNF123 (Ring Finger Protein 123) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ligase activity. An important paralog of this gene is RSPRY1.

UniProtKB/Swiss-Prot for RNF123 Gene

  • Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle.

Gene Wiki entry for RNF123 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF123 Gene

Genomics for RNF123 Gene

Regulatory Elements for RNF123 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RNF123 Gene

49,689,499 bp from pter
49,721,529 bp from pter
32,031 bases
Plus strand

Genomic View for RNF123 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNF123 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF123 Gene

Proteins for RNF123 Gene

  • Protein details for RNF123 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    E3 ubiquitin-protein ligase RNF123
    Protein Accession:
    Secondary Accessions:
    • A1L4Q3
    • A6NLS5
    • Q5I022
    • Q6PFW4
    • Q71RH0
    • Q8IW18
    • Q9H0M8
    • Q9H5L8
    • Q9H9T2

    Protein attributes for RNF123 Gene

    1314 amino acids
    Molecular mass:
    148515 Da
    Quaternary structure:
    • Component of the KPC complex composed of RNF123/KPC1 and UBAC1/KPC2. Interacts with UBAC1 and CDKN1B via its N-terminal domain.
    • Sequence=BAB14139.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15607.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RNF123 Gene

    Alternative splice isoforms for RNF123 Gene


neXtProt entry for RNF123 Gene

Proteomics data for RNF123 Gene at MOPED

Post-translational modifications for RNF123 Gene

  • Ubiquitinated, leading to its degradation. Deubiquitinated by USP19, thereby stimulating CDKN1B ubiquitin-dependent degradation (By similarity).
  • Ubiquitination at Lys33, Lys467, Lys530, Lys704, Lys806, Lys814, Lys906, and Lys1286
  • Modification sites at PhosphoSitePlus

Other Protein References for RNF123 Gene

No data available for DME Specific Peptides for RNF123 Gene

Domains for RNF123 Gene

Gene Families for RNF123 Gene

  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for RNF123 Gene

Suggested Antigen Peptide Sequences for RNF123 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q5XPI4
  • Contains 1 B30.2/SPRY domain.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF123: view

Function for RNF123 Gene

Molecular function for RNF123 Gene

UniProtKB/Swiss-Prot Function: Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle.

Enzyme Numbers (IUBMB) for RNF123 Gene

Gene Ontology (GO) - Molecular Function for RNF123 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with RNF123: view

Animal Model Products

CRISPR Products

miRNA for RNF123 Gene

miRTarBase miRNAs that target RNF123

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RNF123 Gene

Localization for RNF123 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF123 Gene


Subcellular locations from

Jensen Localization Image for RNF123 Gene COMPARTMENTS Subcellular localization image for RNF123 gene
Compartment Confidence
plasma membrane 3
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RNF123 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with RNF123: view

Pathways for RNF123 Gene

genes like me logo Genes that share pathways with RNF123: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q5XPI4-RN123_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for RNF123 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with RNF123: view

Transcripts for RNF123 Gene

Unigene Clusters for RNF123 Gene

Ring finger protein 123:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNF123

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for RNF123

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF123 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b · 20c ^
SP4: -
SP6: -
SP7: -

ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31
SP7: -

Relevant External Links for RNF123 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNF123 Gene

mRNA expression in normal human tissues for RNF123 Gene

mRNA differential expression in normal tissues according to GTEx for RNF123 Gene

This gene is overexpressed in Muscle - Skeletal (7.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RNF123 Gene

SOURCE GeneReport for Unigene cluster for RNF123 Gene Hs.553723

genes like me logo Genes that share expressions with RNF123: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for RNF123 Gene

Orthologs for RNF123 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RNF123 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RNF123 35
  • 98.16 (n)
  • 97.47 (a)
(Bos Taurus)
Mammalia RNF123 35
  • 89.26 (n)
  • 92.47 (a)
RNF123 36
  • 93 (a)
(Canis familiaris)
Mammalia RNF123 35
  • 90.84 (n)
  • 94.52 (a)
RNF123 36
  • 94 (a)
(Mus musculus)
Mammalia Rnf123 35
  • 89.09 (n)
  • 93.84 (a)
Rnf123 16
Rnf123 36
  • 94 (a)
(Monodelphis domestica)
Mammalia RNF123 36
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia RNF123 36
  • 72 (a)
(Rattus norvegicus)
Mammalia Rnf123 35
  • 88.59 (n)
  • 93.67 (a)
(Gallus gallus)
Aves RNF123 35
  • 76.09 (n)
  • 80.15 (a)
RNF123 36
  • 79 (a)
(Anolis carolinensis)
Reptilia RNF123 36
  • 80 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.10089 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf123 35
  • 71.3 (n)
  • 78.48 (a)
Str.7038 35
(Danio rerio)
Actinopterygii LOC101884269 35
  • 72.88 (n)
  • 78.9 (a)
rnf123 36
  • 78 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009295 35
  • 26.27 (n)
  • 6.95 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6752 35
  • 47.34 (n)
  • 34.59 (a)
CG6752 36
  • 23 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons RKP 35
  • 41.17 (n)
  • 30.36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 11 (a)
Species with no ortholog for RNF123:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF123 Gene

Gene Tree for RNF123 (if available)
Gene Tree for RNF123 (if available)

Paralogs for RNF123 Gene

Paralogs for RNF123 Gene

genes like me logo Genes that share paralogs with RNF123: view

Variants for RNF123 Gene

Sequence variations from dbSNP and Humsavar for RNF123 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1491985 -- 49,702,074(-) GAGGT(C/G)AGGTG intron-variant
rs1491986 -- 49,701,653(-) GCCAG(A/G)GGCCT intron-variant
rs2291542 -- 49,714,152(-) TTGGC(A/G)TCCTC reference, synonymous-codon
rs2329017 -- 49,696,245(+) ATGTG(C/G)TATGC intron-variant
rs2329018 -- 49,696,409(+) agtgg(C/T)acgat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNF123 Gene

Variant ID Type Subtype PubMed ID
nsv508217 CNV Loss 20534489
nsv820990 CNV Duplication 20802225
esv28815 CNV Gain+Loss 19812545
nsv822077 CNV Gain 20364138
nsv482082 CNV Gain 20164927

Relevant External Links for RNF123 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF123 Gene

Disorders for RNF123 Gene

Relevant External Links for RNF123

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with RNF123: view

No data available for UniProtKB/Swiss-Prot for RNF123 Gene

Publications for RNF123 Gene

  1. Role of the UBL-UBA protein KPC2 in degradation of p27 at G1 phase of the cell cycle. (PMID: 16227581) Hara T. … Nakayama K. (Mol. Cell. Biol. 2005) 3 4 23
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D. … Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4

Products for RNF123 Gene

Sources for RNF123 Gene

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