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RNF123 Gene

protein-coding   GIFtS: 55
GCID: GC03P049726

Ring Finger Protein 123

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ring Finger Protein 1231 2 3
KPC12 3 5
Kip1 Ubiquitination-Promoting Complex Protein 12 3
E3 Ubiquitin-Protein Ligase RNF1232
EC 6.3.2.-3

External Ids:    HGNC: 211481   Entrez Gene: 638912   Ensembl: ENSG000001640687   OMIM: 6144725   UniProtKB: Q5XPI43   

Export aliases for RNF123 gene to outside databases

Previous GC identifers: GC03P049581 GC03P049685 GC03P049701


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RNF123 Gene:
The protein encoded by this gene contains a C-terminal RING finger domain, a motif present in a variety of
functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions, and an
N-terminal SPRY domain. This protein displays E3 ubiquitin ligase activity toward the cyclin-dependent kinase
inhibitor 1B which is also known as p27 or KIP1. (provided by RefSeq, Feb 2012)

GeneCards Summary for RNF123 Gene:
RNF123 (ring finger protein 123) is a protein-coding gene. GO annotations related to this gene include ligase activity. An important paralog of this gene is RSPRY1.

UniProtKB/Swiss-Prot: RN123_HUMAN, Q5XPI4
Function: Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for
poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle

Gene Wiki entry for RNF123 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RNF123 gene promoter:
         E2F-4   E2F-3a   HFH-3   E2F-5   Nkx2-5   E2F-2   LCR-F1   E2F   E2F-1   SEF-1 (1)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNF123 promoter sequence
   Search Chromatin IP Primers for RNF123

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNF123


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p24.3   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p24.3

RNF123 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF123 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P049726:  view genomic region     (about GC identifiers)

Start:
49,726,932 bp from pter      End:
49,758,962 bp from pter
Size:
32,031 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RN123_HUMAN, Q5XPI4 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase RNF123  
Size: 1314 amino acids; 148515 Da
Subunit: Component of the KPC complex composed of RNF123/KPC1 and UBAC1/KPC2. Interacts with UBAC1 and CDKN1B via
its N-terminal domain
Sequence caution: Sequence=BAB14139.1; Type=Erroneous initiation; Sequence=BAB15607.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for RNF123:
2MA6 (3D)    
Secondary accessions: A1L4Q3 A6NLS5 Q5I022 Q6PFW4 Q71RH0 Q8IW18 Q9H0M8 Q9H5L8 Q9H9T2
Alternative splicing: 2 isoforms:  Q5XPI4-1   Q5XPI4-2   

Explore the universe of human proteins at neXtProt for RNF123: NX_Q5XPI4

Explore proteomics data for RNF123 at MOPED

Post-translational modifications: 

  • Ubiquitinated, leading to its degradation. Deubiquitinated by USP19, thereby stimulating CDKN1B
    ubiquitin-dependent degradation (By similarity)1
  • Ubiquitination2 at Lys33, Lys467, Lys530, Lys704, Lys806, Lys814, Lys906, Lys1286
  • Modification sites at PhosphoSitePlus

  • See RNF123 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_071347.2  
    ENSEMBL proteins: 
     ENSP00000328287   ENSP00000392443   ENSP00000394369   ENSP00000408490   ENSP00000390856  
     ENSP00000416156   ENSP00000413794  
    Reactome Protein details: Q5XPI4

    RNF123 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RNF123

     
    Search eBioscience for Proteins for RNF123 

     
    antibodies-online proteins for RNF123 (2 products) 

     
    Search antibodies-online for peptides for RNF123

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    antibodies-online antibodies for RNF123 (22 products) 

    RNF123 Assay Products:

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    antibodies-online kits for RNF123 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers

    Selected InterPro protein domains (see all 6):
     IPR001841 Znf_RING
     IPR001870 B30.2/SPRY
     IPR003877 SPRY_rcpt
     IPR018355 SPla/RYanodine_receptor_subgr
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q5XPI4

    ProtoNet protein and cluster: Q5XPI4

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: RN123_HUMAN, Q5XPI4
    Similarity: Contains 1 B30.2/SPRY domain
    Similarity: Contains 1 RING-type zinc finger


    Find genes that share domains with RNF123           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RN123_HUMAN, Q5XPI4
    Function: Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for
    poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0016874ligase activity IEA--
         
    Find genes that share ontologies with RNF123           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for RNF123

    miRNA
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    miRTarBase miRNAs that target RNF123:
    hsa-mir-10a-5p (MIRT047567), hsa-mir-92a-3p (MIRT049325)

    Block miRNA regulation of human, mouse, rat RNF123 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RNF123 (see all 10):
    hsa-miR-328 hsa-miR-3136-5p hsa-miR-1260b hsa-miR-1291 hsa-miR-1260 hsa-miR-532-3p hsa-miR-155 hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidRNF123 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RNF123

    Gene Editing
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    OriGene ORF clones in mouse, rat for RNF123
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    GenScript: all cDNA clones in your preferred vector: RNF123 (NM_022064)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNF123
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF123

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RN123_HUMAN, Q5XPI4: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    cytosol1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with RNF123           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RNF123 About    
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84


    Find genes that share SuperPaths with RNF123           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for RNF123
        Antigen processing: Ubiquitination & Proteasome degradation


    UniProtKB/Swiss-Prot: RN123_HUMAN, Q5XPI4
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Arrays including RNF123: 

              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RNF123

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for RNF123 (Q5XPI42, 3 ENSP000003282874) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD2Q157962, 3, ENSP000002621604MINT-60930 I2D: score=3 STRING: ENSP00000262160
    SMAD9O151982, 3, ENSP000003691544MINT-62113 I2D: score=3 STRING: ENSP00000369154
    CDKN1BP465273, ENSP000002288724I2D: score=2 STRING: ENSP00000228872
    PMS1P542773, ENSP000004064904I2D: score=1 STRING: ENSP00000406490
    UBE2WQ96B023, ENSP000003974534I2D: score=1 STRING: ENSP00000397453
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016567protein ubiquitination IEA--

    Find genes that share ontologies with RNF123           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RNF123 (RN123)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RNF123 gene: 
    NM_022064.3  

    Unigene Cluster for RNF123:

    Ring finger protein 123
    Hs.553723  [show with all ESTs]
    Unigene Representative Sequence: CR627051
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000327697(uc003cxh.3) ENST00000432042 ENST00000457726(uc010hky.1 uc003cxi.3)
    ENST00000454491 ENST00000443204 ENST00000486102 ENST00000487805 ENST00000494005
    ENST00000469978 ENST00000433785 ENST00000444689 ENST00000497099 ENST00000498376

    miRNA
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    Block miRNA regulation of human, mouse, rat RNF123 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RNF123 (see all 10):
    hsa-miR-328 hsa-miR-3136-5p hsa-miR-1260b hsa-miR-1291 hsa-miR-1260 hsa-miR-532-3p hsa-miR-155 hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidRNF123 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for RNF123
    Predesigned siRNA for gene silencing in human, mouse, rat RNF123
    Clone
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    OriGene clones in human, mouse for RNF123 (see all 8)
    OriGene ORF clones in mouse, rat for RNF123
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RNF123 (NM_022064)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF123
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for RNF123
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RNF123
      QuantiTect SYBR Green Assays in human, mouse, rat RNF123
      QuantiFast Probe-based Assays in human, mouse, rat RNF123

    Additional mRNA sequence: 

    AF370367.1 AK022627.1 AK026968.1 AK090632.1 AK096353.1 AK126883.1 AK308130.1 AK308607.1 
    AL136729.1 AL832034.1 AL832138.1 AL832344.1 AY744152.1 BC041145.1 BC057392.1 BC088801.1 
    BC112900.1 BC130632.1 CR627051.1 

    24 DOTS entries:

    DT.443599  DT.95366039  DT.120904439  DT.95310662  DT.120904375  DT.97800486  DT.95326952  DT.99938348 
    DT.92441962  DT.95124893  DT.99972057  DT.100878932  DT.120904176  DT.100878941  DT.100737191  DT.120904131 
    DT.120904699  DT.120904703  DT.120904741  DT.95124902  DT.120904152  DT.120904332  DT.120904572  DT.99943689 

    Selected AceView cDNA sequences (see all 194):

    AA583043 CN481340 AL559380 BF059265 CO399700 AA315497 BQ651614 NM_022064 
    BM929934 BM791710 CR618929 BE782259 BX324406 BE041315 BU190204 BF724213 
    AL832138 BX281750 CB130770 AA644221 BC041145 BC057392 H58920 AK090632 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RNF123 (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b · 20c ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                    -                                       
    SP5:                                                                                                                                                            

    ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31
    SP1:                                                                  
    SP2:                                                                  
    SP3:                                                                  
    SP4:                                                                  
    SP5:                                                                  


    ECgene alternative splicing isoforms for RNF123

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RNF123 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCCTAATTG
    RNF123 Expression
    About this image

    RNF123 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RNF123 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.553723
        Pathway & Disease-focused RT2 Profiler PCR Arrays including RNF123: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for RNF123
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    QuantiFast Probe-based Assays in human, mouse, rat RNF123
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF123

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RNF123 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnf1231 , 5 ring finger protein 1231, 5 89.09(n)1
    93.84(a)1
      9 (59.07 cM)5
    845851  NM_032543.21  NP_115932.11 
     1080515345 
    chicken
    (Gallus gallus)
    Aves RNF1231 ring finger protein 123 76.09(n)
    80.15(a)
      415923  XM_003641964.2  XP_003642012.2 
    lizard
    (Anolis carolinensis)
    Reptilia RNF1236
    ring finger protein 123
    80(a)
    1 ↔ 1
    2(147153269-147285743)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.100892 Xenopus laevis transcribed sequence 83.67(n)    48025265 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1018842691 E3 ubiquitin-protein ligase RNF123-like 72.88(n)
    78.9(a)
      101884269  XM_005161843.1  XP_005161900.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG67521 CG6752 47.34(n)
    34.59(a)
      41826  NM_001260187.1  NP_001247116.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons RKP1 RKP 41.17(n)
    30.36(a)
      816737  NM_179689.2  NP_850020.1 


    ENSEMBL Gene Tree for RNF123 (if available)
    TreeFam Gene Tree for RNF123 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RNF123 gene
    RSPRY12  

    Find genes that share paralogs with RNF123           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RNF123 (see all 984)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2008154651,2
    F--49656950(+) CCACTT/CGCCTT 1 -- us2k11Minor allele frequency- C:0.05EU 301
    rs1453008941,2
    F--49656977(+) ACAGCG/ACCCAG 1 -- us2k11Minor allele frequency- A:0.00NA 4494
    rs1891354411,2
    --49657005(+) TGGGGC/TGAGTG 1 -- us2k10--------
    rs1821799921,2
    C--49657006(+) GGGGCA/GAGTGT 1 -- us2k10--------
    rs2018337311,2
    C,F--49657050(+) CTCACG/ATGTAG 1 -- us2k11Minor allele frequency- A:0.29EU 240
    rs1867152781,2
    --49657135(+) GCCCAG/TTGGCC 1 -- us2k10--------
    rs1919966181,2
    C--49657148(+) TCACCA/GGCAGT 1 -- us2k10--------
    rs3738905761,2
    C--49657171(+) CACAGC/TGACCA 1 -- us2k10--------
    rs2011393831,2
    C--49657198(+) CTGCCA/CCATCC 1 -- us2k11Minor allele frequency- C:0.00EU 1323
    rs1133550221,2
    C--49657218(+) GGCCCG/AGGCAC 1 -- us2k11Minor allele frequency- A:0.00EU 1243

    HapMap Linkage Disequilibrium report for RNF123 (49726932 - 49758962 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for RNF123:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv820990CNV Duplication20802225
    nsv508217CNV Loss20534489
    nsv482082CNV Gain20164927
    nsv822077CNV Gain20364138
    esv28815CNV Gain+Loss19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RNF123
    DNA2.0 Custom Variant and Variant Library Synthesis for RNF123

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614472    OMIM disorders: --


    Find genes that share disorders with RNF123           About GenesLikeMe

    Genetic Association Database (GAD): RNF123
    Human Genome Epidemiology (HuGE) Navigator: RNF123 (1 document)

    Export disorders for RNF123 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RNF123 gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with RNF123)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Role of the UBL-UBA protein KPC2 in degradation of p27 at G1 phase of the cell cycle. (PubMed id 16227581)1, 2, 9 Hara T.... Nakayama K. (Mol. Cell. Biol. 2005)
    2. Association analysis of 3p21 with Crohn's disease in a New Zealand population. (PubMed id 20307617)1, 4 Morgan A.R....Ferguson L.R. (Hum. Immunol. 2010)
    3. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    4. Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase. (PubMed id 15531880)1, 2 Kamura T.... Nakayama K. (Nat. Cell Biol. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    8. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    9. A strategy for modulation of enzymes in the ubiquitin system. (PubMed id 23287719)1 Ernst A.... Sidhu S.S. (Science 2013)
    10. Ubiquitin ligase RNF123 mediates degradation of heterochromatin protein 1I+ and I^ in lamin A/C knock-down cells. (PubMed id 23077635)1 Chaturvedi P....Parnaik V.K. (PLoS ONE 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 63891 HGNC: 21148 AceView: RNF123 Ensembl:ENSG00000164068 euGenes: HUgn63891
    ECgene: RNF123 H-InvDB: RNF123

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RNF123 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RNF123 gene:
    Search GeneIP for patents involving RNF123

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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