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Aliases for RNF122 Gene

Aliases for RNF122 Gene

  • Ring Finger Protein 122 2 3 5

External Ids for RNF122 Gene

Previous GeneCards Identifiers for RNF122 Gene

  • GC08M033261
  • GC08M033462
  • GC08M033405
  • GC08M031937

Summaries for RNF122 Gene

Entrez Gene Summary for RNF122 Gene

  • The encoded protein contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. The encoded protein is localized to the endoplasmic reticulum and golgi apparatus, and may be associated with cell viability. [provided by RefSeq, Jul 2013]

GeneCards Summary for RNF122 Gene

RNF122 (Ring Finger Protein 122) is a Protein Coding gene. An important paralog of this gene is RNF24.

UniProtKB/Swiss-Prot for RNF122 Gene

  • May induce necrosis and apoptosis. May play a role in cell viability.

Gene Wiki entry for RNF122 Gene

Additional gene information for RNF122 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF122 Gene

Genomics for RNF122 Gene

Regulatory Elements for RNF122 Gene

Enhancers for RNF122 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08H033560 1.6 FANTOM5 ENCODE dbSUPER 8.7 +2.7 2681 7 PKNOX1 FOXA2 ATF1 SIN3A FEZF1 ZNF2 YY1 ZNF121 GLIS2 ZNF143 FUT10 RNF122 RPL10P18 GC08P033548
GH08H033470 1.1 ENCODE 11.3 +94.8 94825 3.2 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 ZNF207 FUT10 TTI2 SNORD13 LOC100630919 RPL10P18 ENSG00000252505 RNF122 LOC100507379
GH08H033511 1.2 ENCODE 10.3 +53.5 53468 3.4 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF548 SP3 NFYC SSRP1 ZNF610 TTI2 FUT10 MAK16 RNF122 LOC100630919
GH08H033553 1.4 Ensembl ENCODE dbSUPER 5 +10.2 10200 7.5 ELF3 HDGF PKNOX1 FOXA2 TBL1XR1 RARA ZNF143 ATF7 ETV6 RUNX3 FUT10 LOC100630919 SNORD13 TTI2 RNF122 GC08P033548 RPL10P18
GH08H033536 0.4 ENCODE 16.2 +30.9 30931 0.2 SOX13 NR2F2 RNF122 TTI2 SNORD13 GC08P033549 LOC100630919
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RNF122 on UCSC Golden Path with GeneCards custom track

Promoters for RNF122 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000223346 628 2201 PKNOX1 FOXA2 ATF1 SIN3A ZNF2 YY1 ZNF121 GLIS2 ZNF143 ATF7

Genomic Locations for RNF122 Gene

Genomic Locations for RNF122 Gene
19,375 bases
Minus strand

Genomic View for RNF122 Gene

Genes around RNF122 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF122 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF122 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF122 Gene

Proteins for RNF122 Gene

  • Protein details for RNF122 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RING finger protein 122
    Protein Accession:
    Secondary Accessions:
    • Q52LK3

    Protein attributes for RNF122 Gene

    155 amino acids
    Molecular mass:
    17475 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RNF122 Gene

Post-translational modifications for RNF122 Gene

  • Ubiquitination at Lys122
  • Modification sites at PhosphoSitePlus

Other Protein References for RNF122 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RNF122 Gene

Domains & Families for RNF122 Gene

Gene Families for RNF122 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for RNF122 Gene

Suggested Antigen Peptide Sequences for RNF122 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RNF122: view

No data available for UniProtKB/Swiss-Prot for RNF122 Gene

Function for RNF122 Gene

Molecular function for RNF122 Gene

UniProtKB/Swiss-Prot Function:
May induce necrosis and apoptosis. May play a role in cell viability.

Phenotypes From GWAS Catalog for RNF122 Gene

Gene Ontology (GO) - Molecular Function for RNF122 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
GO:0061630 ubiquitin protein ligase activity IBA --
genes like me logo Genes that share ontologies with RNF122: view
genes like me logo Genes that share phenotypes with RNF122: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNF122 Gene

Localization for RNF122 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF122 Gene

Golgi apparatus. Endoplasmic reticulum. Membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNF122 gene
Compartment Confidence
endoplasmic reticulum 4
golgi apparatus 4
plasma membrane 2
extracellular 2
mitochondrion 1
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for RNF122 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RNF122: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RNF122 Gene

Pathways & Interactions for RNF122 Gene

SuperPathways for RNF122 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RNF122 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IBA --
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA --
genes like me logo Genes that share ontologies with RNF122: view

No data available for Pathways by source and SIGNOR curated interactions for RNF122 Gene

Drugs & Compounds for RNF122 Gene

No Compound Related Data Available

Transcripts for RNF122 Gene

mRNA/cDNA for RNF122 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RNF122 Gene

Ring finger protein 122:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF122 Gene

No ASD Table

Relevant External Links for RNF122 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNF122 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNF122 Gene

mRNA differential expression in normal tissues according to GTEx for RNF122 Gene

This gene is overexpressed in Ovary (x4.1).

NURSA nuclear receptor signaling pathways regulating expression of RNF122 Gene:


SOURCE GeneReport for Unigene cluster for RNF122 Gene:


mRNA Expression by UniProt/SwissProt for RNF122 Gene:

Tissue specificity: Widely expressed in several tissues and cell lines.

Evidence on tissue expression from TISSUES for RNF122 Gene

  • Liver(4.1)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with RNF122: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNF122 Gene

Orthologs for RNF122 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNF122 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RNF122 33 34
  • 99.14 (n)
(Canis familiaris)
Mammalia RNF122 33 34
  • 92.88 (n)
(Bos Taurus)
Mammalia RNF122 34 33
  • 91.77 (n)
(Ornithorhynchus anatinus)
Mammalia RNF122 34
  • 90 (a)
(Mus musculus)
Mammalia Rnf122 33 16 34
  • 89.39 (n)
(Monodelphis domestica)
Mammalia RNF122 34
  • 88 (a)
(Gallus gallus)
Aves RNF122 33 34
  • 78.6 (n)
(Anolis carolinensis)
Reptilia RNF122 34
  • 88 (a)
(Danio rerio)
Actinopterygii RNF122 34
  • 83 (a)
LOC100329730 33
  • 77.85 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 34 (a)
Species where no ortholog for RNF122 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF122 Gene

Gene Tree for RNF122 (if available)
Gene Tree for RNF122 (if available)

Paralogs for RNF122 Gene

Paralogs for RNF122 Gene

(2) SIMAP similar genes for RNF122 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RNF122: view

Variants for RNF122 Gene

Sequence variations from dbSNP and Humsavar for RNF122 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000127725 -- 33,554,846(+) CAGAG(A/G)TCAGC intron-variant
rs1000474742 -- 33,561,112(+) TTCCC(C/T)CCGCC intron-variant
rs1000537521 -- 33,561,452(+) CATCA(C/T)CTCCT intron-variant
rs1000546022 -- 33,566,209(+) GCCCG(C/T)GGGAA intron-variant, upstream-variant-2KB
rs1000591400 -- 33,561,759(+) TCTGG(G/T)CTTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNF122 Gene

Variant ID Type Subtype PubMed ID
nsv6146 CNV deletion 18451855
esv3616836 CNV loss 21293372
esv2752251 CNV loss 17911159
esv2666058 CNV deletion 23128226

Variation tolerance for RNF122 Gene

Residual Variation Intolerance Score: 44.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.78; 16.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNF122 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF122 Gene

Disorders for RNF122 Gene

Relevant External Links for RNF122

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RNF122 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF122 Gene

Publications for RNF122 Gene

  1. [Cloning, expression and subcellular localization of a novel human gene-RNF122]. (PMID: 16778963) Wang L … Wang L (Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 2006) 3 4 60
  2. Cell-based screening and validation of human novel genes associated with cell viability. (PMID: 16751333) Wang L … Ma D (Journal of biomolecular screening 2006) 3 4 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. RNF122: a novel ubiquitin ligase associated with calcium-modulating cyclophilin ligand. (PMID: 20553626) Peng Z … Ma D (BMC cell biology 2010) 3 60

Products for RNF122 Gene

Sources for RNF122 Gene

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