RNF122 Gene
protein-coding GIFtS: 46
GCID: GC08M033405
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ring finger protein 122
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Aliases
for RNF122 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ring Finger Protein 1221 2 | | FLJ125261 |
Export aliases for RNF122 gene to outside databasesPrevious GC identifers: GC08M033261 GC08M033462 GC08M033524 GC08M031937 |
Summaries
for RNF122 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RNF122:
The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteinsand known to be involved in protein-protein and protein-DNA interactions. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: RN122_HUMAN, Q9H9V4Function: May induce necrosis and apoptosis. May play a role in cell viability
Gene Wiki entry for RNF122
|
Genomic Views
for RNF122 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_167187.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RNF122 gene promoter:
AML1a GCNF AP-4 E4BP4 NF-kappaB Egr-2 COMP1 GCNF-1 NF-kappaB1 GCNF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for RNF122
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF122 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8p12 Ensembl cytogenetic band: 8p12 HGNC cytogenetic band: 8p12RNF122 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M033405: view genomic region
(about GC identifiers)
Start:
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33,405,273 bp from pter |
End:
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33,424,643 bp from pter |
Size:
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19,371 bases |
Orientation:
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minus strand |
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Proteins
for RNF122 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RN122_HUMAN, Q9H9V4 (See
protein sequence)Recommended Name: RING finger protein 122 Size: 155 amino acids; 17475 Da
Subcellular location: Golgi apparatus. Endoplasmic reticulum. Membrane; Single-pass membrane protein (Potential)
Secondary accessions: Q52LK3Explore the universe of human proteins at neXtProt for RNF122: NX_Q9H9V4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H9V4
RNF122 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_079063.2
ENSEMBL proteins: ENSP00000256257
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
RNF122 for ontologies About GeneDecksing
RNF122 Antibody Products:
Assay Products for RNF122: |
Protein
Domains /
Families
for RNF122 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RNF122 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9H9V4ProtoNet protein and cluster: Q9H9V4 1 Blocks protein family: IPB001841 Zn-finger
UniProtKB/Swiss-Prot: RN122_HUMAN, Q9H9V4Similarity: Contains 1 RING-type zinc finger |
Function
for RNF122 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RN122_HUMAN, Q9H9V4Function: May induce necrosis and apoptosis. May play a role in cell viability
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF122 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF122
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for RNF122 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF122 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF122 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008270 | zinc ion binding |
IEA | -- |
RNF122 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for RNF122:
|
Pathways & Interactions
for RNF122 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNF122
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
4 Interacting proteins for RNF122 (Q9H9V43 ENSP000002562574) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for RNF122 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RNF122
Search CenterWatch for drugs/clinical trials and news about RNF122 / RN122
|
Transcripts
for RNF122 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RNF122 gene: NM_024787.2 Unigene Cluster for RNF122: Ring finger protein 122 Hs.151237 [show with all ESTs]Unigene Representative Sequence: AK0225881 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000256257(uc003xjo.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF122 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF122
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RNF122 (NM_024787) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RNF122 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF122 |
Additional cDNA sequence: AK022588.1 BC093884.1 BC101573.1 2 DOTS entries: DT.433536 DT.95217847 15 AceView cDNA sequences: BX108697 CR623897 NM_024787 AW804626 AU124463 AK022588 AI186169 BF898468 T12502 D38656 BX427394 BF847236 BI010612 R15668 BG012173
GeneLoc Exon Structure
|
Expression
for RNF122 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RNF122 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGAGGTTTG
About this image
See RNF122 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RNF122
SOURCE GeneReport for Unigene cluster: Hs.151237
UniProtKB/Swiss-Prot: RN122_HUMAN, Q9H9V4Tissue specificity: Widely expressed in several tissues and cell lines
SABiosciences Custom PCR Arrays for RNF122
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNF122
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RNF122 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNF122 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNF122 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF122 |
Orthologs
for RNF122 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for RNF122 gene from 5/13 species (see all 13) About this table
ENSEMBL Gene Tree for RNF122 (if available)
TreeFam Gene Tree for RNF122 (if available) |
Paralogs
for RNF122 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RNF122 gene
- RNF242
2 SIMAP similar genes for RNF122 using alignment to 1 protein entry: RN122_HUMAN:RNF24 RNF167
RNF122 for paralogs About GeneDecksing
|
Genomic Variants
for RNF122 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RNF122 (33405273 - 33424643 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for RNF122
1 CNV: 9090 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNF122 |
|
Disorders
/ Diseases
for RNF122 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RNF122 for disorders About GeneDecksing
1  disease for RNF122: About MalaCardsmalaria
Export disorders for RNF122 gene to outside databases
|
Publications
for RNF122 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RNF122 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with RNF122) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cell-based screening and validation of human novel genes associated with cell viability. (PubMed id 16751333)1, 2 Wang L.... Ma D. (2006)
- Cloning, expression and subcellular localization of a novel human gene -- RNF122. (PubMed id 16778963)1, 2 Wang L.... Wang L. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- RNF122: a novel ubiquitin ligase associated with calc ium-modulating cyclophilin ligand. (PubMed id 20553626)1 Peng Z....Ma D. (2010)
- A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. (PubMed id 19690564)1 van Wijk S.J....Timmers H.T. (2009)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
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External Searches for RNF122 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RNF122 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RNF122 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RNF122 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RNF122 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RNF122 gene:
Search GeneIP for patents involving RNF122
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RNF122 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RNF122 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RNF122 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNF122 | | | OriGene Protein Over-expression Lysate for RNF122 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RNF122 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF122 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF122 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for RNF122 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | | RNF122 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF122 |
|  |  |  | | | | Search ThermoFisher Antibodies for RNF122 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF122 |
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