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Aliases for RNF122 Gene

Aliases for RNF122 Gene

  • Ring Finger Protein 122 2 3

External Ids for RNF122 Gene

Previous GeneCards Identifiers for RNF122 Gene

  • GC08M033261
  • GC08M033462
  • GC08M033405
  • GC08M031937

Summaries for RNF122 Gene

Entrez Gene Summary for RNF122 Gene

  • The encoded protein contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. The encoded protein is localized to the endoplasmic reticulum and golgi apparatus, and may be associated with cell viability. [provided by RefSeq, Jul 2013]

GeneCards Summary for RNF122 Gene

RNF122 (Ring Finger Protein 122) is a Protein Coding gene. An important paralog of this gene is RNF24.

UniProtKB/Swiss-Prot for RNF122 Gene

  • May induce necrosis and apoptosis. May play a role in cell viability.

Gene Wiki entry for RNF122 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF122 Gene

Genomics for RNF122 Gene

Regulatory Elements for RNF122 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RNF122 Gene

33,547,754 bp from pter
33,567,128 bp from pter
19,375 bases
Minus strand

Genomic View for RNF122 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNF122 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF122 Gene

Proteins for RNF122 Gene

  • Protein details for RNF122 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RING finger protein 122
    Protein Accession:
    Secondary Accessions:
    • Q52LK3

    Protein attributes for RNF122 Gene

    155 amino acids
    Molecular mass:
    17475 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RNF122 Gene

Proteomics data for RNF122 Gene at MOPED

Post-translational modifications for RNF122 Gene

  • Ubiquitination at Lys 122
  • Modification sites at PhosphoSitePlus

Other Protein References for RNF122 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RNF122 Gene

Domains & Families for RNF122 Gene

Gene Families for RNF122 Gene

Protein Domains for RNF122 Gene


Suggested Antigen Peptide Sequences for RNF122 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 RING-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF122: view

Function for RNF122 Gene

Molecular function for RNF122 Gene

UniProtKB/Swiss-Prot Function:
May induce necrosis and apoptosis. May play a role in cell viability.

Gene Ontology (GO) - Molecular Function for RNF122 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with RNF122: view
genes like me logo Genes that share phenotypes with RNF122: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNF122

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RNF122 Gene

Localization for RNF122 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF122 Gene

Golgi apparatus. Endoplasmic reticulum. Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for RNF122 Gene COMPARTMENTS Subcellular localization image for RNF122 gene
Compartment Confidence
endoplasmic reticulum 3
golgi apparatus 3

Gene Ontology (GO) - Cellular Components for RNF122 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RNF122: view

Pathways & Interactions for RNF122 Gene

SuperPathways for RNF122 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RNF122 Gene


No data available for Pathways by source and SIGNOR curated interactions for RNF122 Gene

Drugs & Compounds for RNF122 Gene

No Compound Related Data Available

Transcripts for RNF122 Gene

mRNA/cDNA for RNF122 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RNF122 Gene

Ring finger protein 122:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNF122

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF122 Gene

No ASD Table

Relevant External Links for RNF122 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNF122 Gene

mRNA expression in normal human tissues for RNF122 Gene

mRNA differential expression in normal tissues according to GTEx for RNF122 Gene

This gene is overexpressed in Ovary (x4.1).

SOURCE GeneReport for Unigene cluster for RNF122 Gene Hs.151237

mRNA Expression by UniProt/SwissProt for RNF122 Gene

Tissue specificity: Widely expressed in several tissues and cell lines.
genes like me logo Genes that share expression patterns with RNF122: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for RNF122 Gene

Orthologs for RNF122 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNF122 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RNF122 35
  • 91.77 (n)
  • 97.4 (a)
RNF122 36
  • 97 (a)
(Canis familiaris)
Mammalia RNF122 35
  • 92.88 (n)
  • 98.47 (a)
RNF122 36
  • 94 (a)
(Mus musculus)
Mammalia Rnf122 35
  • 89.39 (n)
  • 96.75 (a)
Rnf122 16
Rnf122 36
  • 97 (a)
(Pan troglodytes)
Mammalia RNF122 35
  • 99.14 (n)
  • 100 (a)
RNF122 36
  • 100 (a)
(Monodelphis domestica)
Mammalia RNF122 36
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia RNF122 36
  • 90 (a)
(Gallus gallus)
Aves RNF122 35
  • 78.6 (n)
  • 80.41 (a)
RNF122 36
  • 81 (a)
(Anolis carolinensis)
Reptilia RNF122 36
  • 88 (a)
(Danio rerio)
Actinopterygii LOC100329730 35
  • 77.85 (n)
  • 82.58 (a)
RNF122 36
  • 83 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
Species with no ortholog for RNF122:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF122 Gene

Gene Tree for RNF122 (if available)
Gene Tree for RNF122 (if available)

Paralogs for RNF122 Gene

Paralogs for RNF122 Gene

(2) SIMAP similar genes for RNF122 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RNF122: view

Variants for RNF122 Gene

Sequence variations from dbSNP and Humsavar for RNF122 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs754436 -- 33,563,879(+) CTGTG(C/T)ACTCC intron-variant
rs754437 -- 33,564,016(+) AGGTC(A/G)GTGGG intron-variant
rs1440530 -- 33,556,976(-) AAGGC(A/G)GCTAC intron-variant
rs3735948 -- 33,548,176(+) GCGCC(C/G)GCCAG utr-variant-3-prime
rs3735949 -- 33,551,383(+) TTCCG(C/G)AGTTT synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for RNF122 Gene

Variant ID Type Subtype PubMed ID
nsv6146 CNV Loss 18451855
esv2752251 CNV Loss 17911159
esv2666058 CNV Deletion 23128226

Variation tolerance for RNF122 Gene

Residual Variation Intolerance Score: 44.55% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.78; 16.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNF122 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF122 Gene

Disorders for RNF122 Gene

Relevant External Links for RNF122

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RNF122: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF122 Gene

Publications for RNF122 Gene

  1. RNF122: a novel ubiquitin ligase associated with calcium-modulating cyclophilin ligand. (PMID: 20553626) Peng Z. … Ma D. (BMC Cell Biol. 2010) 67
  2. A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. (PMID: 19690564) van Wijk S.J. … Timmers H.T. (Mol. Syst. Biol. 2009) 67
  3. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 67
  4. Cell-based screening and validation of human novel genes associated with cell viability. (PMID: 16751333) Wang L. … Ma D. (J. Biomol. Screen. 2006) 67
  5. Cloning, expression and subcellular localization of a novel human gene -- RNF122. (PMID: 16778963) Wang L. … Wang L. (Beijing Da Xue Xue Bao 2006) 67

Products for RNF122 Gene

Sources for RNF122 Gene

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