Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



RNF122 Gene

protein-coding   GIFtS: 45
GCID: GC08M033405

Ring Finger Protein 122

  Search for RNF122
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Ring Finger Protein 1221 2

External Ids:    HGNC: 211471   Entrez Gene: 798452   Ensembl: ENSG000001338747   UniProtKB: Q9H9V43   

Export aliases for RNF122 gene to outside databases

Previous GC identifers: GC08M033261 GC08M033462 GC08M033524 GC08M031937


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for RNF122 Gene:
The encoded protein contains a RING finger, a motif present in a variety of functionally distinct proteins and
known to be involved in protein-protein and protein-DNA interactions. The encoded protein is localized to the
endoplasmic reticulum and golgi apparatus, and may be associated with cell viability. (provided by RefSeq, Jul
2013)

GeneCards Summary for RNF122 Gene:
RNF122 (ring finger protein 122) is a protein-coding gene. An important paralog of this gene is RNF24.

UniProtKB/Swiss-Prot: RN122_HUMAN, Q9H9V4
Function: May induce necrosis and apoptosis. May play a role in cell viability

Gene Wiki entry for RNF122 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000008.11  NC_018919.2  NT_167187.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RNF122 gene promoter:
         AML1a   GCNF   AP-4   E4BP4   NF-kappaB   Egr-2   COMP1   GCNF-1   NF-kappaB1   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNF122 promoter sequence
   Search Chromatin IP Primers for RNF122

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNF122


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p12   Ensembl cytogenetic band:  8p12   HGNC cytogenetic band: 8p12

RNF122 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF122 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M033405:  view genomic region     (about GC identifiers)

Start:
33,405,273 bp from pter      End:
33,424,643 bp from pter
Size:
19,371 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: RN122_HUMAN, Q9H9V4 (See protein sequence)
Recommended Name: RING finger protein 122  
Size: 155 amino acids; 17475 Da
Secondary accessions: Q52LK3

Explore the universe of human proteins at neXtProt for RNF122: NX_Q9H9V4

Explore proteomics data for RNF122 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys122
  • Modification sites at PhosphoSitePlus

  • See RNF122 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_079063.2  
    ENSEMBL proteins: 
     ENSP00000256257  

    RNF122 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for RNF122
    OriGene Protein Over-expression Lysate for RNF122
    OriGene MassSpec for RNF122
    OriGene Custom Protein Services for RNF122
    GenScript Custom Purified and Recombinant Proteins Services for RNF122
    Novus Biologicals RNF122 Proteins
    Novus Biologicals RNF122 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RNF122

    RNF122 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for RNF122
    Novus Biologicals RNF122 Antibodies
    Abcam antibodies for RNF122
    Cloud-Clone Corp. Antibodies for RNF122
    Search ThermoFisher Antibodies for RNF122
    LSBio Antibodies in human, mouse, rat for RNF122

    RNF122 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RNF122
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RNF122
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RNF122
    Cloud-Clone Corp. CLIAs for RNF122


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers

    2 InterPro protein domains:
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q9H9V4

    ProtoNet protein and cluster: Q9H9V4

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: RN122_HUMAN, Q9H9V4
    Similarity: Contains 1 RING-type zinc finger


    RNF122 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RN122_HUMAN, Q9H9V4
    Function: May induce necrosis and apoptosis. May play a role in cell viability

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0046872metal ion binding ----
         
    RNF122 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for RNF122:
     Decreased viability with pacli  Increased cell death in HCC-19  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RNF122
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RNF122

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RNF122
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RNF122

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat RNF122 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RNF122 (see all 22):
    hsa-miR-30c hsa-miR-3194-5p hsa-miR-520d-5p hsa-miR-218-1* hsa-miR-29a hsa-miR-29c hsa-miR-30d hsa-miR-650
    SwitchGear 3'UTR luciferase reporter plasmidRNF122 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RNF122
    Predesigned siRNA for gene silencing in human, mouse, rat RNF122

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RNF122

    Clone
    Products:
         
    OriGene clones in human, mouse for RNF122 (see all 5)
    OriGene ORF clones in mouse, rat for RNF122
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RNF122 (NM_024787)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNF122
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF122

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RNF122
    Browse ESI BIO Cell Lines and PureStem Progenitors for RNF122 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF122


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    RN122_HUMAN, Q9H9V4: Golgi apparatus. Endoplasmic reticulum. Membrane; Single-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    golgi apparatus5
    extracellular2
    plasma membrane2
    cytosol1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IEA--
    GO:0005794Golgi apparatus IEA--
    GO:0016021integral component of membrane IEA--

    RNF122 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RNF122
    Interactions:

        Search GeneGlobe Interaction Network for RNF122

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for RNF122 (Q9H9V43 ENSP000002562574) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE2L6O149333, ENSP000002871564I2D: score=2 STRING: ENSP00000287156
    CAMLGP490693, ENSP000002971564I2D: score=1 STRING: ENSP00000297156
    UBCENSP000003448184STRING: ENSP00000344818
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    POLR2BENSP000003127354STRING: ENSP00000312735
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RNF122 (RN122)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for RNF122 gene: 
    NM_024787.3  

    Unigene Cluster for RNF122:

    Ring finger protein 122
    Hs.151237  [show with all ESTs]
    Unigene Representative Sequence: AK022588
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000256257(uc003xjo.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RNF122 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RNF122 (see all 22):
    hsa-miR-30c hsa-miR-3194-5p hsa-miR-520d-5p hsa-miR-218-1* hsa-miR-29a hsa-miR-29c hsa-miR-30d hsa-miR-650
    SwitchGear 3'UTR luciferase reporter plasmidRNF122 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RNF122
    Predesigned siRNA for gene silencing in human, mouse, rat RNF122
    Clone
    Products:
         
    OriGene clones in human, mouse for RNF122 (see all 5)
    OriGene ORF clones in mouse, rat for RNF122
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RNF122 (NM_024787)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNF122
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF122
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for RNF122
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RNF122
      QuantiTect SYBR Green Assays in human, mouse, rat RNF122
      QuantiFast Probe-based Assays in human, mouse, rat RNF122

    Additional mRNA sequence: 

    AK022588.1 BC093884.1 BC101573.1 

    2 DOTS entries:

    DT.433536  DT.95217847 

    15 AceView cDNA sequences:

    NM_024787 CR623897 BX108697 AK022588 AI186169 AU124463 AW804626 BF898468 
    D38656 T12502 BF847236 BX427394 BI010612 BG012173 R15668 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    RNF122 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGAGGTTTG
    RNF122 Expression
    About this image

    RNF122 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RNF122 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.151237

    UniProtKB/Swiss-Prot: RN122_HUMAN, Q9H9V4
    Tissue specificity: Widely expressed in several tissues and cell lines

        Custom PCR Arrays for RNF122
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for RNF122
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RNF122
    QuantiTect SYBR Green Assays in human, mouse, rat RNF122
    QuantiFast Probe-based Assays in human, mouse, rat RNF122
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF122

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for RNF122 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnf1221 , 5 ring finger protein 1221, 5 89.39(n)1
    96.75(a)1
      8 (17.97 cM)5
    688671  NM_175136.21  NP_780345.11 
     311118205 
    chicken
    (Gallus gallus)
    Aves RNF1221 ring finger protein 122 78.6(n)
    80.41(a)
      426922  XM_424531.4  XP_424531.3 
    lizard
    (Anolis carolinensis)
    Reptilia RNF1226
    ring finger protein 122
    88(a)
    1 ↔ 1
    GL343238.1(1050093-1075559)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003297301 RING finger protein 122-like 77.85(n)
    82.58(a)
      100329730  XM_002663249.3  XP_002663295.2 


    ENSEMBL Gene Tree for RNF122 (if available)
    TreeFam Gene Tree for RNF122 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for RNF122 gene
    RNF242  
    2 SIMAP similar genes for RNF122 using alignment to 1 protein entry:     RN122_HUMAN:
    RNF24    RNF167

    RNF122 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for RNF122 (see all 469)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1815161641,2
    --33404850(+) TGAGCA/GCAGTG 1 -- ds50010--------
    rs78301191,2
    C,F--33404964(+) caaaaA/Catttt 1 -- ds50011Minor allele frequency- C:0.02WA 118
    rs1391229321,2
    --33404989(+) GCACAC/TGCCTG 1 -- ds50010--------
    rs1858475591,2
    --33404990(+) CACACA/GCCTGT 1 -- ds50010--------
    rs3729681691,2
    C--33405039(+) TGAGCC/TGGGAG 1 -- ds50010--------
    rs1480647181,2
    C--33405150(+) GGAAC-/GTGTGTG 1 -- ds50010--------
    rs1439874891,2
    C--33405167(+) GTATGC/TGTGTG 1 -- ds50010--------
    rs1465199191,2
    C--33405182(+) TGATTC/TGGGTA 1 -- ds50010--------
    rs286666381,2
    C,F--33405315(+) AAATAT/CGTAAC 1 -- ut31 ese38Minor allele frequency- C:0.25NA WA CSA EA 248
    rs1129056871,2
    C,F--33405337(+) CTCACC/ACACTC 1 -- ut311Minor allele frequency- A:0.50CSA 2

    HapMap Linkage Disequilibrium report for RNF122 (33405273 - 33424643 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for RNF122:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2666058CNV Deletion23128226
    nsv6146CNV Loss18451855
    esv2752251CNV Loss17911159

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RNF122
    DNA2.0 Custom Variant and Variant Library Synthesis for RNF122

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for RNF122 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with RNF122)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cell-based screening and validation of human novel genes associated with cell viability. (PubMed id 16751333)1, 2 Wang L.... Ma D. (J. Biomol. Screen. 2006)
    2. Cloning, expression and subcellular localization of a novel human gene -- RNF122. (PubMed id 16778963)1, 2 Wang L.... Wang L. (Beijing Da Xue Xue Bao 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    6. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    7. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    8. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    9. RNF122: a novel ubiquitin ligase associated with calcium-modulating cyclophilin ligand. (PubMed id 20553626)1 Peng Z....Ma D. (BMC Cell Biol. 2010)
    10. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 79845 HGNC: 21147 AceView: RNF122 Ensembl:ENSG00000133874 euGenes: HUgn79845
    ECgene: RNF122 H-InvDB: RNF122

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for RNF122 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for RNF122 gene:
    Search GeneIP for patents involving RNF122

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for RNF122  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for RNF122  
     OriGene MassSpec something-or-other for RNF122   OriGene clones in human, mouse for RNF122  
     OriGene qSTAR qPCR primer pairs in human, mouse for RNF122   OriGene Purified Protein for RNF122  
     OriGene ORF clones in mouse, rat for RNF122   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RNF122   OriGene Custom Protein Services for RNF122  

     
     
     Block miRNA regulation of human, mouse, rat RNF122 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing RNF122
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNF122 Predesigned siRNA for gene silencing in human, mouse, rat RNF122
     QuantiFast Probe-based Assays in human, mouse, rat RNF122 QuantiTect SYBR Green Assays in human, mouse, rat RNF122
     Custom PCR Arrays for RNF122 Search Chromatin IP Primers for RNF122
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RNF122  Search GeneGlobe Interaction Network for RNF122
     Regulatory tfbs in RNF122 promoter
     GenScript Custom Purified and Recombinant Proteins Services for RNF122 GenScript cDNA clones with any tag delivered in your preferred vector for RNF122
     GenScript Custom Assay Services for RNF122 GenScript Custom overexpressing Cell Line Services for RNF122
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for RNF122 (RN122)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     RNF122 antibodies
     RNF122 proteins
     RNF122 lysates
     Antibodies for RNF122
     See all of Abcam's Antibodies, Kits and Proteins for RNF122
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for RNF122
     Antibodies for RNF122
     ELISAs for RNF122
     CLIAs for RNF122



     Browse ESI BIO Cell Lines and PureStem Progenitors for RNF122
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF122
     SwitchGear 3'UTR luciferase reporter plasmids for RNF122
     SwitchGear Promoter luciferase reporter plasmids for RNF122
     Search ThermoFisher Antibodies for RNF122
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF122
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RNF122
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RNF122
     LSBio Antibodies in human, mouse, rat for RNF122
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RNF122 gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4