RNF121 Gene
protein-coding GIFtS: 41
GCID: GC11P071640
|
|
ring finger protein 121
| |
Aliases
for RNF121 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| Ring Finger Protein 1211 2 | | FLJ110991 |
| External Ids: | HGNC: 210701 | Entrez Gene: 552982 | Ensembl: ENSG000001375227 | UniProtKB: Q9H9203 | | ORGUL members: | |
|---|
| NONCODE:n406623 n406622 | |
Export aliases for RNF121 gene to outside databasesPrevious GC identifers: GC11P071862 GC11P071366 GC11P071317 GC11P067933
|---|
Summaries
for RNF121 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RNF121:
The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteinsand known to be involved in protein-protein and protein-DNA interactions. Several alternatively spliced transcriptvariants have been noted for this gene, however, not all are likely to encode viable protein products. (provided byRefSeq, Sep 2008)
|
Genomic Views
for RNF121 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RNF121 gene promoter:
ISGF-3 AML1a E4BP4 FOXL1 IRF-2 CP2 COMP1 c-Myb Zic3
Other transcription factors
Search SABiosciences Chromatin IP Primers for RNF121
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF121 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q13.4 Ensembl cytogenetic band: 11q13.4 HGNC cytogenetic band: 11q13.3RNF121 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P071640: view genomic region
(about GC identifiers)
Start:
|
71,639,747 bp from pter |
End:
|
71,708,643 bp from pter |
Size:
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68,897 bases |
Orientation:
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plus strand |
ORGUL member locations:
Legend (see complete legend)
 |
Proteins
for RNF121 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RN121_HUMAN, Q9H920 (See
protein sequence)Recommended Name: RING finger protein 121 Size: 327 amino acids; 37882 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=AAH09672.2; Type=Erroneous initiation; Sequence=AAH63680.1; Type=Erroneous initiation;
Secondary accessions: Q6IA57 Q6P449 Q96DB4Explore the universe of human proteins at neXtProt for RNF121: NX_Q9H920
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H920
RNF121 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060790.2
ENSEMBL proteins: ENSP00000354571 ENSP00000431325 ENSP00000377314 ENSP00000432898 ENSP00000433574 ENSP00000377316 ENSP00000434127 ENSP00000435859 ENSP00000431286 ENSP00000443799
Human Recombinant Protein Products for RNF121:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
RNF121 for ontologies About GeneDecksing
RNF121 Antibody Products:
Assay Products for RNF121: |
Protein
Domains /
Families
for RNF121 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RNF121 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9H920ProtoNet protein and cluster: Q9H920 1 Blocks protein family: IPB001841 Zn-finger
UniProtKB/Swiss-Prot: RN121_HUMAN, Q9H920Similarity: Belongs to the RNF121 familySimilarity: Contains 1 RING-type zinc finger |
Function
for RNF121 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008270 | zinc ion binding |
IEA | -- |
RNF121 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF121 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF121
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RNF121 (NM_018320) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RNF121 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF121 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF121 |
|
Pathways & Interactions
for RNF121 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNF121
|
Drugs & Compounds
for RNF121 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RNF121
Search CenterWatch for drugs/clinical trials and news about RNF121 / RN121
|
Transcripts
for RNF121 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RNF121 gene (3 alternative transcripts): NM_018320.4 NM_194452.1 NM_194453.1 Unigene Cluster for RNF121: Ring finger protein 121 Hs.368554 [show with all ESTs]Unigene Representative Sequence: NR_02414815 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000361756(uc001ord.3 uc001ora.3 uc001orb.3 uc009yst.3)
ENST00000530058 ENST00000393711 ENST00000530655 ENST00000533380 ENST00000393713
ENST00000490867 ENST00000528683 ENST00000526549 ENST00000525243 ENST00000530137
ENST00000526903 ENST00000525176 ENST00000532379 ENST00000545854
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF121 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF121
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RNF121 (NM_018320) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RNF121 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF121 |
Additional cDNA sequence: AK001961.1 AK023139.1 AK094508.1 AL833638.1 BC009672.2 BC063680.1 BC093084.1 BC117273.1 CR457298.1 NR_024147.1 NR_024148.1 11 DOTS entries: DT.100814850 DT.101982502 DT.120683668 DT.70100736 DT.100024016 DT.120683629 DT.91995046 DT.95373403 DT.100701778 DT.120683578 DT.75121316 24/111 AceView cDNA sequences (see all 111): CR625242 AI963986 BF904376 AL548102 CA396524 BI916895 NM_194453 BM562917 AL561161 BG682750 CD516294 AU131066 AI038812 NM_018320 AL541224 NM_194452 BQ773387 BM904164 BG122855 BC063680 BM668205 AW513661 BX463021 AL833638
GeneLoc Exon Structure
|
Expression
for RNF121 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RNF121 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGCTGGGTTG
About this image
See RNF121 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RNF121
SOURCE GeneReport for Unigene cluster: Hs.368554
SABiosciences Expression via Pathway-Focused PCR Array including RNF121:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNF121
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RNF121 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNF121 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNF121 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF121 |
Orthologs
for RNF121 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for RNF121 gene from 6/24 species (see all 24) About this table
ENSEMBL Gene Tree for RNF121 (if available)
TreeFam Gene Tree for RNF121 (if available) |
Paralogs
for RNF121 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RNF121 gene
- RNF1752
3 SIMAP similar genes for RNF121 using alignment to 11 protein entries: RN121_HUMAN (see all proteins):L3MBTL2 RNF175 ETFA
RNF121 for paralogs About GeneDecksing
|
Genomic Variants
for RNF121 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RNF121 (71639747 - 71708643 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for RNF121
1 CNV: 3857
1 Indel: 11059 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNF121 |
|
Disorders
/ Diseases
for RNF121 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for RNF121 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RNF121 gene integrated from 9 sources:
(articles sorted by number of sources associating them with RNF121) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for RNF121 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RNF121 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RNF121 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RNF121 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RNF121 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RNF121 gene:
Search GeneIP for patents involving RNF121
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RNF121 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RNF121 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RNF121 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNF121 | | | OriGene Protein Over-expression Lysate for RNF121 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RNF121 | | OriGene 3'-UTR Clone for RNF121 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF121 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF121 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
 |  |  |  | |
| | | | Search Tocris compounds for RNF121 |
| |  |  |  |  | | | | |
 |
 |
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 | | | RNF121 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF121 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for RNF121 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF121 |
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