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Aliases for RNF121 Gene

Aliases for RNF121 Gene

  • Ring Finger Protein 121 2 3 5

External Ids for RNF121 Gene

Previous GeneCards Identifiers for RNF121 Gene

  • GC11P071862
  • GC11P071366
  • GC11P071317
  • GC11P071640
  • GC11P067933

Summaries for RNF121 Gene

Entrez Gene Summary for RNF121 Gene

  • The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. Several alternatively spliced transcript variants have been noted for this gene, however, not all are likely to encode viable protein products. [provided by RefSeq, Sep 2008]

GeneCards Summary for RNF121 Gene

RNF121 (Ring Finger Protein 121) is a Protein Coding gene. GO annotations related to this gene include ubiquitin protein ligase activity. An important paralog of this gene is RNF175.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF121 Gene

Genomics for RNF121 Gene

Regulatory Elements for RNF121 Gene

Enhancers for RNF121 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RNF121 on UCSC Golden Path with GeneCards custom track

Promoters for RNF121 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RNF121 on UCSC Golden Path with GeneCards custom track

Genomic Location for RNF121 Gene

71,928,701 bp from pter
71,997,597 bp from pter
68,897 bases
Plus strand

Genomic View for RNF121 Gene

Genes around RNF121 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF121 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF121 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF121 Gene

Proteins for RNF121 Gene

  • Protein details for RNF121 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RING finger protein 121
    Protein Accession:
    Secondary Accessions:
    • B3KSW8
    • Q6IA57
    • Q6P449
    • Q96DB4

    Protein attributes for RNF121 Gene

    327 amino acids
    Molecular mass:
    37882 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH09672.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH63680.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RNF121 Gene


neXtProt entry for RNF121 Gene

Proteomics data for RNF121 Gene at MOPED

Post-translational modifications for RNF121 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RNF121 Gene

Domains & Families for RNF121 Gene

Gene Families for RNF121 Gene

Protein Domains for RNF121 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the RNF121 family.
  • Contains 1 RING-type zinc finger.
  • Belongs to the RNF121 family.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF121: view

Function for RNF121 Gene

genes like me logo Genes that share phenotypes with RNF121: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNF121 Gene

Localization for RNF121 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF121 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for RNF121 Gene COMPARTMENTS Subcellular localization image for RNF121 gene
Compartment Confidence
endoplasmic reticulum 4
golgi apparatus 4
plasma membrane 3
peroxisome 2

No data available for Gene Ontology (GO) - Cellular Components for RNF121 Gene

Pathways & Interactions for RNF121 Gene

SuperPathways for RNF121 Gene

No Data Available

Interacting Proteins for RNF121 Gene

Gene Ontology (GO) - Biological Process for RNF121 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030968 endoplasmic reticulum unfolded protein response IBA --
genes like me logo Genes that share ontologies with RNF121: view

No data available for Pathways by source and SIGNOR curated interactions for RNF121 Gene

Drugs & Compounds for RNF121 Gene

No Compound Related Data Available

Transcripts for RNF121 Gene

Unigene Clusters for RNF121 Gene

Ring finger protein 121:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNF121 Gene

No ASD Table

Relevant External Links for RNF121 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNF121 Gene

mRNA expression in normal human tissues for RNF121 Gene

Protein differential expression in normal tissues from HIPED for RNF121 Gene

This gene is overexpressed in Nasal epithelium (64.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RNF121 Gene

SOURCE GeneReport for Unigene cluster for RNF121 Gene Hs.368554

genes like me logo Genes that share expression patterns with RNF121: view

Protein tissue co-expression partners for RNF121 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RNF121 Gene

Orthologs for RNF121 Gene

This gene was present in the common ancestor of animals.

Orthologs for RNF121 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RNF121 35
  • 94.33 (n)
  • 98.98 (a)
RNF121 36
  • 99 (a)
(Canis familiaris)
Mammalia RNF121 35
  • 94.09 (n)
  • 99.39 (a)
RNF121 36
  • 94 (a)
(Mus musculus)
Mammalia Rnf121 35
  • 91.54 (n)
  • 98.17 (a)
Rnf121 16
Rnf121 36
  • 98 (a)
(Pan troglodytes)
Mammalia RNF121 35
  • 99.59 (n)
  • 100 (a)
RNF121 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Rnf121 35
  • 91.85 (n)
  • 97.86 (a)
(Monodelphis domestica)
Mammalia RNF121 36
  • 93 (a)
(Gallus gallus)
Aves RNF121 35
  • 84.51 (n)
  • 94.46 (a)
RNF121 36
  • 91 (a)
(Anolis carolinensis)
Reptilia RNF121 36
  • 83 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75651 35
rnf121 35
  • 80.94 (n)
  • 90.83 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC69129 35
(Danio rerio)
Actinopterygii rnf121 35
  • 73.6 (n)
  • 80.12 (a)
rnf121 36
  • 77 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10586 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008041 35
  • 62.05 (n)
  • 61.72 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG15814 35
  • 64.7 (n)
  • 60 (a)
CG15814 36
  • 57 (a)
(Caenorhabditis elegans)
Secernentea rnf-121 35
  • 57.11 (n)
  • 54.33 (a)
rnf-121 36
  • 39 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8704 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 64 (a)
Species with no ortholog for RNF121:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RNF121 Gene

Gene Tree for RNF121 (if available)
Gene Tree for RNF121 (if available)

Paralogs for RNF121 Gene

Paralogs for RNF121 Gene

genes like me logo Genes that share paralogs with RNF121: view

Variants for RNF121 Gene

Sequence variations from dbSNP and Humsavar for RNF121 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs947932 -- 71,945,659(-) TCTTC(C/T)TTGTA intron-variant
rs1892920 -- 71,991,385(-) tggca(C/T)atagc intron-variant
rs1892921 -- 71,991,092(-) tcaac(C/T)gttgt intron-variant
rs1939241 -- 71,994,083(-) gaggg(C/T)ggatc intron-variant
rs2032352 -- 71,932,912(+) GGAGG(A/G)ATGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNF121 Gene

Variant ID Type Subtype PubMed ID
dgv396e1 CNV Complex 17122850
nsv428262 CNV Gain+Loss 18775914
nsv509428 CNV Insertion 20534489
esv32752 CNV Loss 17666407

Variation tolerance for RNF121 Gene

Residual Variation Intolerance Score: 26.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.64; 13.65% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RNF121 Gene

Disorders for RNF121 Gene

Relevant External Links for RNF121

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RNF121 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF121 Gene

Publications for RNF121 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Really interesting new gene finger protein 121 is a novel Golgi-localized membrane protein that regulates apoptosis. (PMID: 24928685) Zhao Y. … Chen Y. (Acta Biochim. Biophys. Sin. (Shanghai) 2014) 3
  3. The E3 ubiquitin ligase RNF121 is a positive regulator of NF-I_B activation. (PMID: 25388546) Zemirli N. … Arnoult D. (Cell Commun. Signal 2014) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for RNF121 Gene

Sources for RNF121 Gene